Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionALS______
DateThu Feb 9 13:17:35 GMT 2012
Unique Job ID7990b189dc06fcec

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3fxiA_
Top template information
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex
Confidence and coverage
Confidence:100.0% Coverage: 88%
535 residues ( 88% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC
Secondary structure 
SS confidence 
Disorder  ????
??
??
??????
??
??????
??
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG
Secondary structure 
SS confidence 
Disorder 
?
???
?
?????
??
??
???
????
?
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN
Secondary structure 
SS confidence 
Disorder 
????????
??
???
????
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ
Secondary structure 
SS confidence 
Disorder 
??
???
??
??
????
??
??
????
??
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN
Secondary structure 
SS confidence 
Disorder 
???
?
??
??
?
????
??
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG
Secondary structure 
SS confidence 
Disorder  ???
????
??
???
????
??
???
??
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN
Secondary structure 
SS confidence 
Disorder 
?
?
?
??
?????
??
??
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP
Secondary structure 
SS confidence 
Disorder 
??
??
??
?
?
??
????????
???
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC
Secondary structure 
SS confidence 
Disorder  ??
???
?
?
??
?
???????
?
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA
Secondary structure 
SS confidence 
Disorder 
?
???????????
?
?
?
?
Disorder confidence 
 
   .....
Sequence  HFAPC
Secondary structure 
SS confidence 
Disorder 
????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3fxi chain A

3D model

Region: 43 - 598
Aligned: 535
Modelled: 539
Confidence: 100.0%
Identity: 21%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex

Phyre2

PDB 2a0z chain A

3D model

Region: 43 - 603
Aligned: 538
Modelled: 545
Confidence: 100.0%
Identity: 22%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 3;
PDBTitle: the molecular structure of toll-like receptor 3 ligand binding domain

Phyre2

PDB 2z64 chain A

3D model

Region: 44 - 605
Aligned: 538
Modelled: 545
Confidence: 100.0%
Identity: 23%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of mouse tlr4 and mouse md-2 complex

Phyre2

PDB 3j0a chain B

3D model

Region: 45 - 598
Aligned: 527
Modelled: 536
Confidence: 100.0%
Identity: 24%
PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 5;
PDBTitle: homology model of human toll-like receptor 5 fitted into an electron2 microscopy single particle reconstruction

Phyre2

PDB 2z63 chain A

3D model

Region: 43 - 588
Aligned: 523
Modelled: 527
Confidence: 100.0%
Identity: 20%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tv8 hybrid of human tlr4 and hagfish vlrb.61

Phyre2

PDB 1ziw chain A

3D model

Region: 57 - 554
Aligned: 498
Modelled: 498
Confidence: 100.0%
Identity: 22%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 3;
PDBTitle: human toll-like receptor 3 extracellular domain structure

Phyre2

PDB 2z81 chain A

3D model

Region: 45 - 604
Aligned: 522
Modelled: 534
Confidence: 100.0%
Identity: 20%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide

Phyre2

PDB 3a79 chain A

3D model

Region: 43 - 604
Aligned: 525
Modelled: 540
Confidence: 100.0%
Identity: 21%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex

Phyre2

PDB 2id5 chain D

3D model

Region: 41 - 598
Aligned: 363
Modelled: 370
Confidence: 100.0%
Identity: 32%
PDB header:ligand binding protein,membrane protein
Chain: D: PDB Molecule:leucine rich repeat neuronal 6a;
PDBTitle: crystal structure of the lingo-1 ectodomain

Phyre2

PDB 3rgx chain A

3D model

Region: 11 - 605
Aligned: 585
Modelled: 595
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:protein brassinosteroid insensitive 1;
PDBTitle: structural insight into brassinosteroid perception by bri1

Phyre2

PDB 3a79 chain B

3D model

Region: 55 - 604
Aligned: 516
Modelled: 518
Confidence: 100.0%
Identity: 20%
PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 6, variable lymphocyte receptor b;
PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex

Phyre2

PDB 2z7x chain B

3D model

Region: 54 - 604
Aligned: 511
Modelled: 532
Confidence: 100.0%
Identity: 18%
PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 1, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide

Phyre2

PDB 1ozn chain A

3D model

Region: 40 - 605
Aligned: 279
Modelled: 282
Confidence: 100.0%
Identity: 37%
Fold: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily: L domain-like
Family: Ngr ectodomain-like

Phyre2

PDB 3rg1 chain I

3D model

Region: 42 - 582
Aligned: 395
Modelled: 405
Confidence: 100.0%
Identity: 16%
PDB header:immune system
Chain: I: PDB Molecule:cd180 molecule;
PDBTitle: crystal structure of the rp105/md-1 complex

Phyre2

PDB 3oja chain B

3D model

Region: 31 - 550
Aligned: 355
Modelled: 357
Confidence: 100.0%
Identity: 25%
PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex

Phyre2

PDB 2z66 chain A

3D model

Region: 41 - 597
Aligned: 295
Modelled: 300
Confidence: 100.0%
Identity: 31%
PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor b, toll-like receptor 4;
PDBTitle: crystal structure of the vt3 hybrid of human tlr4 and hagfish vlrb.61

Phyre2

PDB 2z80 chain A

3D model

Region: 40 - 604
Aligned: 314
Modelled: 334
Confidence: 100.0%
Identity: 22%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide

Phyre2

PDB 2o6q chain A

3D model

Region: 38 - 605
Aligned: 256
Modelled: 260
Confidence: 100.0%
Identity: 59%
PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor a;
PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors a29

Phyre2

PDB 2omw chain A

3D model

Region: 68 - 603
Aligned: 433
Modelled: 443
Confidence: 100.0%
Identity: 13%
PDB header:cell invasion/cell adhesion
Chain: A: PDB Molecule:internalin-a;
PDBTitle: crystal structure of inla s192n y369s/mec1 complex

Phyre2

PDB 2omz chain A domain 2

3D model

Region: 63 - 536
Aligned: 370
Modelled: 376
Confidence: 100.0%
Identity: 19%
Fold: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily: L domain-like
Family: Internalin LRR domain

Phyre2
1
c3fxiA_
2
c2a0zA_
3
c2z64A_
4
c3j0aB_
5
c2z63A_
6
c1ziwA_
7
c2z81A_
8
c3a79A_
9
c2id5D_
10
c3rgxA_
11
c3a79B_
12
c2z7xB_
13
d1ozna_
14
c3rg1I_
15
c3ojaB_
16
c2z66A_
17
c2z80A_
18
c2o6qA_
19
c2omwA_
20
d2omza2
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
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88



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3fxiA_
100.0 21 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex
2c2a0zA_
100.0 22 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 3;
PDBTitle: the molecular structure of toll-like receptor 3 ligand binding domain
3c2z64A_
100.0 23 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of mouse tlr4 and mouse md-2 complex
4c3j0aB_
100.0 24 PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 5;
PDBTitle: homology model of human toll-like receptor 5 fitted into an electron2 microscopy single particle reconstruction
5c2z63A_
100.0 20 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tv8 hybrid of human tlr4 and hagfish vlrb.61
6c1ziwA_
100.0 22 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 3;
PDBTitle: human toll-like receptor 3 extracellular domain structure
7c2z81A_
100.0 20 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide
8c3a79A_
100.0 21 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex
9c2id5D_
100.0 32 PDB header:ligand binding protein,membrane protein
Chain: D: PDB Molecule:leucine rich repeat neuronal 6a;
PDBTitle: crystal structure of the lingo-1 ectodomain
10c3rgxA_
100.0 19 PDB header:transferase
Chain: A: PDB Molecule:protein brassinosteroid insensitive 1;
PDBTitle: structural insight into brassinosteroid perception by bri1
11c3a79B_
100.0 20 PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 6, variable lymphocyte receptor b;
PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex
12c2z7xB_
100.0 18 PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 1, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide
13d1ozna_
100.0 37 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Ngr ectodomain-like
14c3rg1I_
100.0 16 PDB header:immune system
Chain: I: PDB Molecule:cd180 molecule;
PDBTitle: crystal structure of the rp105/md-1 complex
15c3ojaB_
100.0 25 PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex
16c2z66A_
100.0 31 PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor b, toll-like receptor 4;
PDBTitle: crystal structure of the vt3 hybrid of human tlr4 and hagfish vlrb.61
17c2z80A_
100.0 22 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide
18c2o6qA_
100.0 59 PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor a;
PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors a29
19c2omwA_
100.0 13 PDB header:cell invasion/cell adhesion
Chain: A: PDB Molecule:internalin-a;
PDBTitle: crystal structure of inla s192n y369s/mec1 complex
20d2omza2
100.0 19 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Internalin LRR domain
21c2v9sC_
not modelled 100.0 39 PDB header:structural protein
Chain: C: PDB Molecule:slit homolog 2 protein n-product;
PDBTitle: second lrr domain of human slit2
22c2v70D_
not modelled 100.0 31 PDB header:structural protein
Chain: D: PDB Molecule:slit homolog 2 protein n-product;
PDBTitle: third lrr domain of human slit2
23c2ft3B_
not modelled 100.0 21 PDB header:structural protein, signaling protein
Chain: B: PDB Molecule:biglycan;
PDBTitle: crystal structure of the biglycan dimer core protein
24d1xkua_
not modelled 100.0 29 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Ngr ectodomain-like
25c1xkuA_
not modelled 100.0 29 PDB header:structural protein
Chain: A: PDB Molecule:decorin;
PDBTitle: crystal structure of the dimeric protein core of decorin, the2 archetypal small leucine-rich repeat proteoglycan
26c2z62A_
not modelled 100.0 28 PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tv3 hybrid of human tlr4 and hagfish vlrb.61
27d1p9ag_
not modelled 100.0 60 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Ngr ectodomain-like
28c3o6nA_
not modelled 100.0 27 PDB header:protein binding
Chain: A: PDB Molecule:apl1;
PDBTitle: crystal structure of apl1 leucine-rich repeat domain
29c1ookG_
not modelled 100.0 45 PDB header:hydrolase
Chain: G: PDB Molecule:platelet glycoprotein ib alpha chain precursor;
PDBTitle: crystal structure of the complex of platelet receptor gpib-alpha and2 human alpha-thrombin
30c2xotA_
not modelled 100.0 30 PDB header:cell adhesion
Chain: A: PDB Molecule:amphoterin-induced protein 1;
PDBTitle: crystal structure of neuronal leucine rich repeat protein amigo-1
31d1ogqa_
not modelled 100.0 22 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Polygalacturonase inhibiting protein PGIP
32c3e6jA_
not modelled 100.0 36 PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor diversity region;
PDBTitle: crystal structure of variable lymphocyte receptor (vlr) rbc36 in2 complex with h-trisaccharide
33c3bz5A_
not modelled 100.0 13 PDB header:cell adhesion
Chain: A: PDB Molecule:internalin-j;
PDBTitle: functional domain of inlj from listeria monocytogenes2 includes a cysteine ladder
34c2r9uC_
not modelled 100.0 29 PDB header:immune system
Chain: C: PDB Molecule:variable lymphocyte receptor;
PDBTitle: crystal structure of lamprey variable lymphocyte receptor 29132 ectodomain
35c2o6rA_
not modelled 100.0 36 PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor b;
PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors b61
36c2ifgB_
not modelled 99.9 17 PDB header:transferase
Chain: B: PDB Molecule:high affinity nerve growth factor receptor;
PDBTitle: structure of the extracellular segment of human trka in complex with2 nerve growth factor
37c3ojaA_
not modelled 99.9 23 PDB header:protein binding
Chain: A: PDB Molecule:leucine-rich immune molecule 1;
PDBTitle: crystal structure of lrim1/apl1c complex
38c2o6sA_
not modelled 99.9 39 PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor b;
PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors b59
39d1w8aa_
not modelled 99.9 34 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Ngr ectodomain-like
40c3g3aA_
not modelled 99.9 34 PDB header:hydrolase/immune system
Chain: A: PDB Molecule:variable lymphocyte receptor vlrb.2d;
PDBTitle: structure of a lamprey variable lymphocyte receptor in2 complex with a protein antigen
41c2wfhB_
not modelled 99.9 33 PDB header:splicing
Chain: B: PDB Molecule:slit homolog 2 protein c-product;
PDBTitle: the human slit 2 dimerization domain d4
42d1z7xw1
not modelled 99.9 17 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:28-residue LRR
43c3g06A_
not modelled 99.9 48 PDB header:ligase
Chain: A: PDB Molecule:ssph2 (leucine-rich repeat protein);
PDBTitle: the salmonella virulence effector ssph2 functions as a2 novel e3 ligase
44d2bnha_
not modelled 99.9 16 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:28-residue LRR
45c1g9uA_
not modelled 99.9 23 PDB header:toxin
Chain: A: PDB Molecule:outer protein yopm;
PDBTitle: crystal structure of yopm-leucine rich effector protein from yersinia2 pestis
46d1jl5a_
not modelled 99.9 23 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Leucine rich effector protein YopM
47c3o53A_
not modelled 99.9 16 PDB header:protein binding
Chain: A: PDB Molecule:protein lrim1;
PDBTitle: crystal structure of lrim1 leucine-rich repeat domain
48d2ifga3
not modelled 99.9 19 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Ngr ectodomain-like
49d1xwdc1
not modelled 99.9 30 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Ngr ectodomain-like
50c3m18A_
not modelled 99.9 34 PDB header:immune system
Chain: A: PDB Molecule:variable lymphocyte receptor a diversity region;
PDBTitle: crystal structure of variable lymphocyte receptor vlra.r2.1 in complex2 with hen egg lysozyme
51c1wwlA_
not modelled 99.8 38 PDB header:immune system
Chain: A: PDB Molecule:monocyte differentiation antigen cd14;
PDBTitle: crystal structure of cd14
52c1ltxA_
not modelled 99.8 26 PDB header:transferase/protein binding
Chain: A: PDB Molecule:rab geranylgeranyltransferase alpha subunit;
PDBTitle: structure of rab escort protein-1 in complex with rab2 geranylgeranyl transferase and isoprenoid
53c1m9sA_
not modelled 99.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:internalin b;
PDBTitle: crystal structure of internalin b (inlb), a listeria2 monocytogenes virulence protein containing sh3-like3 domains.
54c2y5qA_
not modelled 99.8 24 PDB header:protein binding
Chain: A: PDB Molecule:internalin b;
PDBTitle: listeria monocytogenes inlb (internalin b) residues 36-392
55c2uzyA_
not modelled 99.8 17 PDB header:signaling protein/receptor
Chain: A: PDB Molecule:internalin b;
PDBTitle: structure of the human receptor tyrosine kinase met in2 complex with the listeria monocytogenes invasion protein3 inlb: low resolution, crystal form ii
56c1h6uA_
not modelled 99.7 20 PDB header:cell adhesion
Chain: A: PDB Molecule:internalin h;
PDBTitle: internalin h: crystal structure of fused n-terminal2 domains.
57c3rfeB_
not modelled 99.7 33 PDB header:cell adhesion
Chain: B: PDB Molecule:platelet glycoprotein ib beta chain;
PDBTitle: crystal structure of glycoprotein gpib ectodomain
58c3cvrA_
not modelled 99.7 30 PDB header:ligase
Chain: A: PDB Molecule:invasion plasmid antigen;
PDBTitle: crystal structure of the full length ipah3
59c3g04C_
not modelled 99.7 34 PDB header:immune system
Chain: C: PDB Molecule:thyrotropin receptor;
PDBTitle: crystal structure of the tsh receptor in complex with a thyroid-2 stimulating autoantibody
60c2je0E_
not modelled 99.7 24 PDB header:nuclear protein
Chain: E: PDB Molecule:acidic leucine-rich nuclear phosphoprotein 32 family
PDBTitle: crystal structure of pp32
61d2astb2
not modelled 99.6 19 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:Cyclin A/CDK2-associated p19, Skp2
62d2ca6a1
not modelled 99.6 14 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:Rna1p (RanGAP1), N-terminal domain
63c1k5dL_
not modelled 99.5 15 PDB header:signaling protein/signaling activator
Chain: L: PDB Molecule:ran gtpase activating protein 1;
PDBTitle: crystal structure of ran-gppnhp-ranbp1-rangap complex
64d1dcea3
not modelled 99.5 31 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Rab geranylgeranyltransferase alpha-subunit, C-terminal domain
65d2omxa2
not modelled 99.4 18 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Internalin LRR domain
66c1otnA_
not modelled 99.4 14 PDB header:cell adhesion
Chain: A: PDB Molecule:internalin b;
PDBTitle: calcium-binding mutant of the internalin b lrr domain
67d1a9na_
not modelled 99.4 19 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:U2A'-like
68c1xeuA_
not modelled 99.4 14 PDB header:cell invasion
Chain: A: PDB Molecule:internalin c;
PDBTitle: crystal structure of internalin c from listeria2 monocytogenes
69d1h6ua2
not modelled 99.3 43 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Internalin LRR domain
70d1h6ta2
not modelled 99.3 55 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:Internalin LRR domain
71c3gozA_
not modelled 99.3 37 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:leucine-rich repeat-containing protein;
PDBTitle: crystal structure of the leucine-rich repeat-containing2 protein legl7 from legionella pneumophila. northeast3 structural genomics consortium target lgr148
72c2ra8A_
not modelled 99.1 16 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein q64v53_bacfr;
PDBTitle: crystal structure of the q64v53_bacfr protein from bacteroides2 fragilis. northeast structural genomics consortium target bfr43
73c3sb4B_
not modelled 99.0 15 PDB header:protein binding
Chain: B: PDB Molecule:hypothetical leucine rich repeat protein;
PDBTitle: crystal structure of a hypothetical leucine rich repeat protein2 (bt_1240) from bacteroides thetaiotaomicron vpi-5482 at 1.99 a3 resolution
74d1m9la_
not modelled 99.0 23 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:Outer arm dynein light chain 1
Family:Outer arm dynein light chain 1
75c2p1nE_
not modelled 98.9 14 PDB header:signaling protein
Chain: E: PDB Molecule:transport inhibitor response 1 protein;
PDBTitle: mechanism of auxin perception by the tir1 ubiqutin ligase
76d1fs2a2
not modelled 98.7 15 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:Cyclin A/CDK2-associated p19, Skp2
77d1koha1
not modelled 98.7 26 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:L domain-like
Family:mRNA export factor tap
78c1kooD_
not modelled 98.6 27 PDB header:rna binding protein
Chain: D: PDB Molecule:tip associating protein;
PDBTitle: the crystal structure and mutational analysis of a novel2 rna-binding domain found in the human tap nuclear mrna3 export factor
79c3oglD_
not modelled 98.6 13 PDB header:protein binding
Chain: D: PDB Molecule:coronatine-insensitive protein 1;
PDBTitle: structure of coi1-ask1 in complex with ja-isoleucine and the jaz12 degron
80c3ogmB_
not modelled 98.6 12 PDB header:protein binding
Chain: B: PDB Molecule:coronatine-insensitive protein 1;
PDBTitle: structure of coi1-ask1 in complex with coronatine and the jaz1 degron
81c3e2jA_
not modelled 98.5 18 PDB header:electron transport
Chain: A: PDB Molecule:atp synthase subunit s, mitochondrial;
PDBTitle: crystal structure of bovine coupling factor b
82c1fqvK_
not modelled 97.9 15 PDB header:ligase
Chain: K: PDB Molecule:skp2;
PDBTitle: insights into scf ubiquitin ligases from the structure of2 the skp1-skp2 complex
83d1pgva_
not modelled 97.5 16 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:28-residue LRR
84c1pgvA_
not modelled 97.5 16 PDB header:protein binding
Chain: A: PDB Molecule:tropomodulin tmd-1;
PDBTitle: structural genomics of caenorhabditis elegans: tropomodulin2 c-terminal domain
85d1io0a_
not modelled 97.2 16 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily:RNI-like
Family:28-residue LRR
86c3ghgD_
not modelled 24.4 33 PDB header:blood clotting
Chain: D: PDB Molecule:fibrinogen alpha chain;
PDBTitle: crystal structure of human fibrinogen
87c1m1jA_
not modelled 17.8 25 PDB header:blood clotting
Chain: A: PDB Molecule:fibrinogen alpha subunit;
PDBTitle: crystal structure of native chicken fibrinogen with two different2 bound ligands
88c2a45J_
not modelled 15.4 33 PDB header:hydrolase/hydrolase inhibitor
Chain: J: PDB Molecule:fibrinogen alpha chain;
PDBTitle: crystal structure of the complex between thrombin and the central "e"2 region of fibrin

Binding site prediction 

The top ranking model of your protein (c3fxiA_ 100.0% confidence) has been submitted to the 3DLigandSite server to predict potential binding sites.

Results will appear here when complete

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0