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Job DescriptionALS______
Confidence100.00%DateThu Feb 9 13:17:35 GMT 2012
Rank2Aligned Residues538
% Identity22%Templatec2a0zA_
PDB info PDB header:immune systemChain: A: PDB Molecule:toll-like receptor 3; PDBTitle: the molecular structure of toll-like receptor 3 ligand binding domain
Resolution2.40 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   43......50.........60.........70.........80.........90.........100.........110.........120..
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Query Sequence  AACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE
Query Conservation    
 
          
 
    

 

  
   
  
 

 
 
  
    
  
  
  
 

 
 
  
 
  
  
 
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Template Conservation    
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Template Sequence  TKCTVSHEV. . . . . . ADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLP
Template Known Secondary structure 


TT......

SS

SS

SSS
TT
S

SS





GGGGTT
TT
S

SS





TT
T
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   26...30.... .....40.........50.........60.........70.........80.........90.........
 
   123......130.........140.........150.........160.........170.........180.........190.........200..
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Query Sequence  NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLA
Query Conservation   
  
 

 
 
  
    
  
  
  
 

 
 
             
  
                           
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Template Conservation   
  
 

 
 
  
    
  
  
  
 

 
 
          
  
  
 

 
            
  
  
   
Template Sequence  MLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLS
Template Known Secondary structure  T



SS





TTTTTT
TT
S
TTS





S
TTTT
TT



SS







SSS

TT



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   100.........110.........120.........130.........140.........150.........160.........170.........
 
   203......210.........220.........230.........240.........250.........260.........270.........280..
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Query Sequence  GNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL
Query Conservation                                                                                  
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Template Conservation                                                                                  
Template Sequence  NNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQ
Template Known Secondary structure  SS



B
GGGTGGGTT
S

S




B
TTTTTTSS

TT



TTTS



TTS
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   180.........190.........200.........210.........220.........230.........240.........250.........
 
   283.
Predicted Secondary structure 

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Query Sequence  ED. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation    ..............................................................................
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Template Conservation                                               
                                  
Template Sequence  LSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSIS
Template Known Secondary structure 


TTTTGGGGGS



TTS



TTTTTT
TT



S

B

TTTTTT
TT


TT
B



SS
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   260.........270.........280.........290.........300.........310.........320.........330.........
 
   285....290.........300.........310.....
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . TFPGLLGLRVLRLSHNAIASLRPRTFKDLHF
Query Conservation  .................................................                               
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Template Conservation                                                                                  
Template Sequence  LASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKI
Template Known Secondary structure  S




TTTTTT
TT



S

B



TTSSTT
TT


TT
BS



SSTTGGGTTS




SS

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   340.........350.........360.........370.........380.........390.........400.........410.........
 
   316...320.........330.........340.........350.........360.........370.........380.........390.....
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Query Sequence  LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG
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Template Conservation                                                                                  
Template Sequence  SKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSP
Template Known Secondary structure 

TTTTTT
TT



SS



SGGGTT
TT



S
S

TTTTTT
TT



SS

B
TT
SS
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   420.........430.........440.........450.........460.........470.........480.........490.........
 
   396...400.........410.........420.........430.........440.........450.........460.........470.....
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Query Sequence  SCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA
Query Conservation                                                                  
  
 
          
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Template Conservation          
                       
       
 
  
               
  
  
 

 
 
  
  
Template Sequence  SPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPV
Template Known Secondary structure 
TTTT
TT



SS





TTTTTT
TT



SS

GGGGSTTSTT



TTTT
TT



SS





T
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   500.........510.........520.........530.........540.........550.........560.........570.........
 
   476...480.........490.........500.........510.........520.... .....530.........540... ......
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Query Sequence  DALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ. . . . . PPGLERLWLEGNPWDCGCP. LKALRD
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Template Conservation    
  
  
  
 

 
 
       
  
  
  
 

 
 
  
        
  
  
 
  

  
 
  
     
Template Sequence  EVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVN
Template Known Secondary structure  TTTTT
TT



SS





TTTTTT
TT


TTS





TT
S

S


S
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   580.........590.........600.........610.........620.........630.........640.........650.........
 
   550.........560.........570.........580.........590.........600...
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Query Sequence  FALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFA
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Template Conservation                ................   
  
    
  
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Template Sequence  WINETHTNIPELSS. . . . . . . . . . . . . . . . HYLCNTPPHYHGFPVRLFDTSS. C
Template Known Secondary structure 

SB
TT................
BSTTSTT
BGGG


TT.
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   660.........670... ......680.........690..... .
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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