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Job DescriptionALS______
Confidence100.00%DateThu Feb 9 13:17:35 GMT 2012
Rank3Aligned Residues538
% Identity23%Templatec2z64A_
PDB info PDB header:immune systemChain: A: PDB Molecule:toll-like receptor 4; PDBTitle: crystal structure of mouse tlr4 and mouse md-2 complex
Resolution2.84 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   44.....50.........60.........70.........80.........90.........100.........110.........120...
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Query Sequence  ACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLEN
Query Conservation   
 
          
 
    

 

  
   
  
 

 
 
  
    
  
  
  
 

 
 
  
 
  
  
  
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Template Conservation            ....  

   
  

  
   
  
 

 
 
  
    
  
  
  
 

 
 
  
    
  
  
Template Sequence  PCIEVVPNIT. . . . YQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHH
Template Known Secondary structure 

TTT....
SSS

SS

SSS
SS



SS



TTTTSS
TT


SS




TTTTTT
TT
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   27..30...... ...40.........50.........60.........70.........80.........90.........100..
 
   124.....130.........140.........150.........160.........170.........180......... 190.........200..
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Query Sequence  LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAA. FRGLGSLRELVLA
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Template Conservation 
  
 

 
 
  
    
  
  
  
 
  
 
  
       
  
  
 
  
                
  
   
Template Sequence  LSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLS
Template Known Secondary structure 


TT






TTTTTT
TT


TTS



TTT


TT
TT



SS







GGGGT
TT


T
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   103......110.........120.........130.........140.........150.........160.........170.........180..
 
   203......210.........220.........230
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Query Sequence  GNRLAYLQPALFSGLAELRELDLSRNAL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation   
                                                                              
Template Sequence  YNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEF
Template Known Secondary structure  TS



TTTTTTTTT
TT



TT




TTTTTTS

SST
S

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   183......190.........200.........210.........220.........230.........240.........250.........260..
 
   231........240.........250.........260.........270.........280.........290.........300.......
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Query Sequence  . . . RAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRP
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Template Conservation                                               
                                  
Template Sequence  KDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQ
Template Known Secondary structure  TTSS

S


GGGGTTTTTS


SS

TTGGG
GGGTT
SS









TT


SS


SS
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   263......270.........280.........290.........300.........310.........320.........330.........340..
 
   308.310.........320.........330.........340.........350.........360.........370.........380.......
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Query Sequence  RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK
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Template Conservation                                   
                                             
Template Sequence  FPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEEL
Template Known Secondary structure 





TT

SBSS

B





TT



SBS
B
SS
S




S
S
S

TT
TT
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   343......350.........360.........370.........380.........390.........400.........410.........420..
 
   388.390.........400.........410.........420.........430.........440.........450 .........460......
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Query Sequence  LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP. HRLFQGLGKLEYLLLS
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Template Conservation                          
                       
  
 
  
                
  
 

Template Sequence  QHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLS
Template Known Secondary structure 

TTSSTTTS
TTTT
TT


TTS



S
TTTT
TT


TT
GGG
STTSS
TT
S
T
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   423......430.........440.........450.........460.........470.........480.........490.........500..
 
   467..470.........480.........490.........500.........510.........520.... .....530.........540..
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Query Sequence  RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ. . . . PPGLERLWLEGNPWDCGC
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Template Conservation   
 
  
    
  
  
  
 

 
 
  
    
  
  
  
 

 
 
             
  
 
  
   
 
Template Sequence  KCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACIC
Template Known Secondary structure  T




TTTTTT
TT



SS


GGGTTT
TT



SS


S
GGGS
TT



S

B

SG
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   503......510.........520.........530.........540.........550.........560.........570.........580..
 
   543......550.........560.........570.........580.........590.........600.....
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Query Sequence  PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC
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Template Conservation         

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Template Sequence  EHQKFLQWVKEQKQFLV. . . . . . . . . . . . . . . . . NVEQMTCATPVEMNTSLVLDF. . . NNSTC
Template Known Secondary structure  GGTGGGBT.................TGGG
BB
SSS
SS
BGGG

...S
TT
Template Predicted Secondary structure 






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   583......590......... 600.........610.........620 .....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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