Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	E	I	Y	E	Q	A	K	H	S	L	Q	G	E	D	F	S	S	F	N	Y	L	F	A	V	N	K	L	L	S	N	P	V	S	Y	D	L	G	R	D	L	I	V	R	A	L	D	S	R	E	R	F	S	E	H	T	T	I	L
Secondary structure
SS confidence
Disorder		?	?	?								?	?		?	?	?														?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	N	M	V	R	K	S	G	L	F	P	Y	L	K	K	E	F	T	S	L	T	P	D	D	L	R	V	L	E	L	Y	R	T	P	F	S	D	G	Y	V	F	H	S	M	Q	F	H	I	F	D	L	L	K	S	G	Q	N	V	V	L
Secondary structure
SS confidence
Disorder																?		?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	A	P	T	S	M	G	K	S	A	I	V	D	S	L	L	G	M	G	T	L	K	R	L	V	L	V	V	P	T	V	A	L	A	D	E	T	R	R	R	L	Q	E	R	F	G	D	R	Y	Q	I	I	H	H	S	S	Q	V	C	H
Secondary structure
SS confidence
Disorder																																																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	D	Q	A	V	Y	V	L	T	Q	E	R	V	N	E	R	D	D	I	V	D	I	D	L	F	V	I	D	E	F	Y	K	L	A	F	R	Q	L	K	S	G	D	I	D	H	Q	D	E	R	V	I	E	L	N	I	A	L	S	K	L
Secondary structure
SS confidence
Disorder																																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	K	V	S	R	Q	F	Y	L	T	G	P	F	V	N	S	I	R	G	L	E	K	L	G	Y	P	H	T	F	V	S	T	D	F	N	T	V	A	L	D	V	K	T	F	G	I	K	A	N	D	D	K	A	K	L	K	A	L	G	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	A	H	A	C	V	D	A	T	I	I	Y	C	K	S	P	T	V	A	G	L	V	A	R	E	L	I	R	L	G	H	G	T	P	T	E	N	P	H	V	D	W	V	S	E	E	F	D	A	D	W	D	Y	T	V	A	L	R	N	G
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	G	L	H	F	G	A	L	P	R	A	L	Q	Q	Y	T	A	D	Q	F	N	A	G	K	L	R	F	L	L	C	T	S	T	I	I	E	G	V	N	T	I	A	K	N	V	V	I	Y	D	N	R	D	G	T	R	S	I	D	K	F
Secondary structure
SS confidence
Disorder																																																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	H	G	N	I	K	G	R	A	G	R	M	G	V	H	F	V	G	K	I	F	C	L	E	E	I	P	E	D	N	L	N	Q	E	V	D	I	P	L	G	I	Q	G	I	D	T	P	I	N	L	L	A	S	V	Q	P	D	H	L	S
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?	?	?	?	?	?						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		E	F	S	Q	D	R	F	D	E	V	F	I	N	D	R	V	S	I	D	L	V	K	K	H	S	Y	F	R	V	E	Q	F	E	M	L	Q	S	M	F	E	M	M	D	D	N	E	F	S	S	L	V	F	H	W	T	P	A	T	N	F
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?							?	?	?	?		?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		L	K	T	F	A	K	I	I	A	R	L	V	P	H	T	F	S	R	N	G	V	P	V	K	P	T	D	V	M	I	A	K	L	A	G	Y	L	S	A	E	S	Y	S	E	Y	L	K	N	Q	I	D	Y	A	R	Q	W	I	S	E	G
Secondary structure
SS confidence
Disorder																			?	?	?			?																																?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		E	K	R	T	L	S	I	A	L	N	N	D	L	K	L	I	T	N	T	F	G	Y	T	L	P	K	V	L	S	L	M	E	D	V	V	K	H	H	A	V	K	R	G	I	R	S	K	V	D	Y	T	H	V	K	L	A	F	E	S	F
Secondary structure
SS confidence
Disorder		?	?	?																																						?	?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		H	L	P	P	G	V	N	A	L	E	E	I	G	I	P	I	Q	T	L	H	R	L	V	D	L	L	E	F	S	D	E	A	D	V	D	E	L	S	Q	Y	L	R	D	T	Q	D	I	W	S	R	S	I	G	Y	V	D	Q	M	F	I
Secondary structure
SS confidence
Disorder						?							?	?	?	?											?		?	?																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		R	R	A	L	G	I	R	R	H
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3l9o chain A Region: 94 - 497 Aligned: 387 Modelled: 393 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent rna helicase dob1; PDBTitle: crystal structure of mtr4, a co-factor of the nuclear exosome Phyre2 PDB 2xgj chain A Region: 98 - 497 Aligned: 385 Modelled: 389 Confidence: 100.0% Identity: 21% PDB header:hydrolase/rna Chain: A: PDB Molecule:atp-dependent rna helicase dob1; PDBTitle: structure of mtr4, a dexh helicase involved in nuclear rna2 processing and surveillance Phyre2 PDB 4a4z chain A Region: 96 - 502 Aligned: 392 Modelled: 407 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:antiviral helicase ski2; PDBTitle: crystal structure of the s. cerevisiae dexh helicase ski2 bound to2 amppnp Phyre2 PDB 2zj2 chain A Region: 75 - 682 Aligned: 576 Modelled: 584 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:putative ski2-type helicase; PDBTitle: archaeal dna helicase hjm apo state in form 1 Phyre2 PDB 2p6u chain A Region: 100 - 727 Aligned: 584 Modelled: 594 Confidence: 100.0% Identity: 15% PDB header:dna binding protein Chain: A: PDB Molecule:afuhel308 helicase; PDBTitle: apo structure of the hel308 superfamily 2 helicase Phyre2 PDB 2va8 chain A Region: 76 - 686 Aligned: 565 Modelled: 582 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:ski2-type helicase; PDBTitle: dna repair helicase hel308 Phyre2 PDB 3rc8 chain A Region: 100 - 464 Aligned: 306 Modelled: 313 Confidence: 100.0% Identity: 18% PDB header:hydrolase/rna Chain: A: PDB Molecule:atp-dependent rna helicase supv3l1, mitochondrial; PDBTitle: human mitochondrial helicase suv3 in complex with short rna fragment Phyre2 PDB 2v1x chain B Region: 76 - 468 Aligned: 348 Modelled: 357 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:atp-dependent dna helicase q1; PDBTitle: crystal structure of human recq-like dna helicase Phyre2 PDB 1oyw chain A Region: 76 - 468 Aligned: 348 Modelled: 361 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent dna helicase; PDBTitle: structure of the recq catalytic core Phyre2 PDB 1gm5 chain A Region: 98 - 456 Aligned: 303 Modelled: 309 Confidence: 100.0% Identity: 17% PDB header:helicase Chain: A: PDB Molecule:recg; PDBTitle: structure of recg bound to three-way dna junction Phyre2 PDB 2eyq chain A Region: 98 - 449 Aligned: 302 Modelled: 309 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:transcription-repair coupling factor; PDBTitle: crystal structure of escherichia coli transcription-repair2 coupling factor Phyre2 PDB 1gl9 chain B Region: 75 - 477 Aligned: 364 Modelled: 369 Confidence: 100.0% Identity: 17% PDB header:topoisomerase Chain: B: PDB Molecule:reverse gyrase; PDBTitle: archaeoglobus fulgidus reverse gyrase complexed with adpnp Phyre2 PDB 2db3 chain D Region: 71 - 466 Aligned: 349 Modelled: 365 Confidence: 100.0% Identity: 19% PDB header:hydrolase/rna Chain: D: PDB Molecule:atp-dependent rna helicase vasa; PDBTitle: structural basis for rna unwinding by the dead-box protein2 drosophila vasa Phyre2 PDB 3kx2 chain A Region: 102 - 445 Aligned: 312 Modelled: 327 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:pre-mrna-splicing factor atp-dependent rna PDBTitle: crystal structure of prp43p in complex with adp Phyre2 PDB 3bxz chain A Region: 74 - 443 Aligned: 325 Modelled: 335 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:preprotein translocase subunit seca; PDBTitle: crystal structure of the isolated dead motor domains from2 escherichia coli seca Phyre2 PDB 3ews chain A Region: 71 - 463 Aligned: 345 Modelled: 360 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent rna helicase ddx19b; PDBTitle: human dead-box rna-helicase ddx19 in complex with adp Phyre2 PDB 3tmi chain A Region: 98 - 455 Aligned: 327 Modelled: 335 Confidence: 100.0% Identity: 16% PDB header:hydrolase/rna Chain: A: PDB Molecule:atp-dependent rna helicase ddx58; PDBTitle: structural basis for rna recognition and activation of rig-i Phyre2 PDB 3oiy chain B Region: 98 - 456 Aligned: 317 Modelled: 320 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: B: PDB Molecule:reverse gyrase helicase domain; PDBTitle: helicase domain of reverse gyrase from thermotoga maritima Phyre2 PDB 2jlr chain A Region: 112 - 447 Aligned: 275 Modelled: 296 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:serine protease subunit ns3; PDBTitle: dengue virus 4 ns3 helicase in complex with amppnp Phyre2 PDB 3i5y chain A Region: 74 - 456 Aligned: 347 Modelled: 353 Confidence: 100.0% Identity: 14% PDB header:hydrolase/rna Chain: A: PDB Molecule:atp-dependent rna helicase mss116; PDBTitle: structure of mss116p bound to ssrna containing a single 5-bru and amp-2 pnp Phyre2 1 c3l9oA_ 2 c2xgjA_ 3 c4a4zA_ 4 c2zj2A_ 5 c2p6uA_ 6 c2va8A_ 7 c3rc8A_ 8 c2v1xB_ 9 c1oywA_ 10 c1gm5A_ 11 c2eyqA_ 12 c1gl9B_ 13 c2db3D_ 14 c3kx2A_ 15 c3bxzA_ 16 c3ewsA_ 17 c3tmiA_ 18 c3oiyB_ 19 c2jlrA_ 20 c3i5yA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499