Phyre 2 Results for P36006

Email	l.a.kelley@imperial.ac.uk
Description	P36006
Date	Mon Jul 2 19:17:52 BST 2012
Unique Job ID	4e076328807e4d82

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3j04A_

Top template information

PDB header:structural protein
Chain: A: PDB Molecule:myosin-11;
PDBTitle: em structure of the heavy meromyosin subfragment of chick smooth2 muscle myosin with regulatory light chain in phosphorylated state

Confidence and coverage

Confidence:

100.0%

Coverage:

63%

800 residues ( 63% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A V I K K G A R R K D V K E P K K R S A K I K K A T F D A N K K K E V G I S D L T L L S K I S D E S I N E N L K K R F

Secondary structure

SS confidence

Disorder ? ?
? ?
? ? ? ?
? ? ? ? ?
? ?
? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence K N G I I Y T Y I G H V L I S V N P F R D L G I Y T N A V L E S Y K G K N R L E V P P H V F A I A E S M Y Y N L K S Y N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence E N Q C V I I S G E S G A G K T E A A K R I M Q Y I A A A S N S H S E S I G K I K D M V L A T N P L L E S F G C A K T L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence R N N N S S R H G K Y L E I K F N S Q F E P C A G N I T N Y L L E K Q R V V G Q I K N E R N F H I F Y Q F T K G A S D T

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence Y K Q M F G V Q M P E Q Y I Y T A A A G C T T A D T I D D V K D Y E G T L E A M R T I G L V Q E E Q D Q I F R M L A A I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence L W I G N I S F I E N E E G N A Q V G D T S V T D F V A Y L L Q V D A S L L V K C L V E R I M Q T S H G M K R G S V Y H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence V P L N P V Q A T A V R D A L A K A I Y N N L F D W I V D R V N V S L Q A F P G A D K S I G I L D I Y G F E I F E H N S

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence F E Q I C I N Y V N E K L Q Q I F I Q L T L K A E Q E T Y E R E K I K W T P I K Y F D N K V V C D L I E A K N P P G I L

Secondary structure

SS confidence

Disorder
? ?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence A A M N D S I A T A H A D S N A A D Q A F A Q R L N L F N S N P Y F E L R A N K F V I K H Y A G D V T Y D I N G I T D K

Secondary structure

SS confidence

Disorder
?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence N K D Q L Q K D L I E L I G T T T N T F L S T I F P D D V D K D S K R R P P T A G D K I I K S A N E L V E T L S K A E P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence S Y I R T I K P N Q T K S P N D Y D D H Q V L H Q V K Y L G L Q E N V R I R R A G F A Y R Q T F E K F V E R F Y L L S P

Secondary structure

SS confidence

Disorder
?
? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence D C S Y A G D Y T W D G D T L E A V K L I L R D A M I P E K E F Q L G V T S V F I K T P E S L F A L E D M R D K Y W Y N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence M A A R I Q R A W R R F L Q R R I D A A I K I Q R T I R E K K G G N K Y V K L R D Y G T K L L A G K K E R R S M S L L G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Y R A F M G D Y L S C N E S K T K G S Y I R R Q V G I K D K V V F S I K G E C L H S K F G R S A Q R L K K V F I L T K K

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence T F Y I I G Q T R E Q N A M K Y T Q D Y K I D V G K I K Q V S L T N L Q D D W M G V I L V N S T Q S D P L I N T P F K T

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ?
? ?
? ?
?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence E L M T R L K K L N E K I M I K V G P T I E Y H K Q P N K L H T V R S K I S D S A P K Y G D I Y K S S T I Y V R R G H P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence A N S K S N K K P K N P G G L S G K P I K S K K S K H K S T H K H T H S H R S H R D A A K K Q P L P S Q K P V N P L S L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence A A T A A Q A A Y N P K P D K T V P I K S S A I P A A K V S S K H S S K P S S K E K V A V K K A S S S H K S S S A K Q N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence Q V S M P P S K G V E K N K E P L K E T T A T A T A N I P I P P P P P P M G Q P K D P K F E A A Y D F P G S G S S S E L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence P L K K G D I V F I S R D E P S G W S L A K L L D G S K E G W V P T A Y M T P Y K D T R N T V P V A A T G A V N D V T N

Secondary structure

SS confidence

Disorder ?
? ?
? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence Q K S S Q I D N T I S S A Q E G V Q F G S A T V G P T S D N Q S N P V G T F S D G L A S A L A A R A N K M R A E S A D D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . .

Sequence D D N D D G D D D D D W

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3j04 chain A

Region: 3 - 822
Aligned: 800
Modelled: 820
Confidence: 100.0%
Identity: 32%
PDB header:structural protein
Chain: A: PDB Molecule:myosin-11;
PDBTitle: em structure of the heavy meromyosin subfragment of chick smooth2 muscle myosin with regulatory light chain in phosphorylated state

Phyre2

PDB 1i84 chain V

Region: 3 - 817
Aligned: 793
Modelled: 806
Confidence: 100.0%
Identity: 32%
PDB header:contractile protein
Chain: V: PDB Molecule:smooth muscle myosin heavy chain;
PDBTitle: cryo-em structure of the heavy meromyosin subfragment of2 chicken gizzard smooth muscle myosin with regulatory light3 chain in the dephosphorylated state. only c alphas4 provided for regulatory light chain. only backbone atoms5 provided for s2 fragment.

Phyre2

PDB 2bki chain A

Region: 3 - 756
Aligned: 736
Modelled: 754
Confidence: 100.0%
Identity: 34%
PDB header:motor protein/metal-binding protein
Chain: A: PDB Molecule:unconventional myosin;
PDBTitle: myosin vi nucleotide-free (mdinsert2-iq) crystal structure

Phyre2

PDB 2otg chain A

Region: 3 - 760
Aligned: 726
Modelled: 754
Confidence: 100.0%
Identity: 35%
PDB header:contractile protein
Chain: A: PDB Molecule:myosin heavy chain;
PDBTitle: rigor-like structures of muscle myosins reveal key2 mechanical elements in the transduction pathways of this3 allosteric motor

Phyre2

PDB 2bkh chain A

Region: 3 - 754
Aligned: 723
Modelled: 742
Confidence: 100.0%
Identity: 34%
PDB header:motor protein/metal-binding protein
Chain: A: PDB Molecule:unconventional myosin;
PDBTitle: myosin vi nucleotide-free (mdinsert2) crystal structure

Phyre2

PDB 1br4 chain E

Region: 3 - 744
Aligned: 720
Modelled: 742
Confidence: 100.0%
Identity: 34%
PDB header:muscle protein
Chain: E: PDB Molecule:myosin;
PDBTitle: smooth muscle myosin motor domain-essential light chain2 complex with mgadp.bef3 bound at the active site

Phyre2

PDB 2ycu chain A

Region: 3 - 878
Aligned: 860
Modelled: 876
Confidence: 100.0%
Identity: 29%
PDB header:motor protein
Chain: A: PDB Molecule:non muscle myosin 2c, alpha-actinin;
PDBTitle: crystal structure of human non muscle myosin 2c in pre-power stroke2 state

Phyre2

PDB 2dfs chain A

Region: 24 - 914
Aligned: 853
Modelled: 880
Confidence: 100.0%
Identity: 34%
PDB header:contractile protein/transport protein
Chain: A: PDB Molecule:myosin-5a;
PDBTitle: 3-d structure of myosin-v inhibited state

Phyre2

PDB 1g8x chain B

Region: 3 - 871
Aligned: 853
Modelled: 869
Confidence: 100.0%
Identity: 31%
PDB header:structural protein
Chain: B: PDB Molecule:myosin ii heavy chain fused to alpha-actinin 3;
PDBTitle: structure of a genetically engineered molecular motor

Phyre2

PDB 3dtp chain A

Region: 3 - 893
Aligned: 869
Modelled: 891
Confidence: 100.0%
Identity: 29%
PDB header:contractile protein
Chain: A: PDB Molecule:myosin 2 heavy chain chimera of smooth and
PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map

Phyre2

PDB 1kk8 chain A domain 2

Region: 10 - 764
Aligned: 713
Modelled: 755
Confidence: 100.0%
Identity: 36%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Motor proteins

Phyre2

PDB 1oe9 chain A

Region: 3 - 744
Aligned: 698
Modelled: 732
Confidence: 100.0%
Identity: 37%
PDB header:atpase/myosin
Chain: A: PDB Molecule:myosin va;
PDBTitle: crystal structure of myosin v motor with essential light2 chain - nucleotide-free

Phyre2

PDB 1d0x chain A domain 2

Region: 2 - 715
Aligned: 685
Modelled: 712
Confidence: 100.0%
Identity: 36%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Motor proteins

Phyre2

PDB 1w7j chain A domain 2

Region: 30 - 742
Aligned: 682
Modelled: 700
Confidence: 100.0%
Identity: 38%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Motor proteins

Phyre2

PDB 2vb6 chain A

Region: 3 - 753
Aligned: 683
Modelled: 730
Confidence: 100.0%
Identity: 35%
PDB header:motor protein
Chain: A: PDB Molecule:myosin vi;
PDBTitle: myosin vi (md-insert2-cam, delta insert1) post-rigor state (2 crystal form 2)

Phyre2

PDB 1w8j chain D

Region: 24 - 717
Aligned: 661
Modelled: 686
Confidence: 100.0%
Identity: 38%
PDB header:motor protein
Chain: D: PDB Molecule:myosin va;
PDBTitle: crystal structure of myosin v motor domain -2 nucleotide-free

Phyre2

PDB 1w9i chain A

Region: 3 - 710
Aligned: 652
Modelled: 667
Confidence: 100.0%
Identity: 37%
PDB header:myosin
Chain: A: PDB Molecule:myosin ii heavy chain;
PDBTitle: myosin ii dictyostelium discoideum motor domain s456y bound2 with mgadp-befx

Phyre2

PDB 1lkx chain A

Region: 37 - 714
Aligned: 638
Modelled: 678
Confidence: 100.0%
Identity: 47%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Motor proteins

Phyre2

PDB 1br2 chain C

Region: 11 - 715
Aligned: 651
Modelled: 690
Confidence: 100.0%
Identity: 36%
PDB header:muscle protein
Chain: C: PDB Molecule:myosin;
PDBTitle: smooth muscle myosin motor domain complexed with mgadp.alf4

Phyre2

PDB 1o1a chain P

Region: 3 - 754
Aligned: 709
Modelled: 716
Confidence: 100.0%
Identity: 31%
PDB header:contractile protein
Chain: P: PDB Molecule:skeletal muscle myosin ii;
PDBTitle: molecular models of averaged rigor crossbridges from2 tomograms of insect flight muscle

Phyre2

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	V	I	K	K	G	A	R	R	K	D	V	K	E	P	K	K	R	S	A	K	I	K	K	A	T	F	D	A	N	K	K	K	E	V	G	I	S	D	L	T	L	L	S	K	I	S	D	E	S	I	N	E	N	L	K	K	R	F
Secondary structure
SS confidence
Disorder	?	?				?	?		?	?	?	?		?	?	?	?	?											?	?		?	?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	K	N	G	I	I	Y	T	Y	I	G	H	V	L	I	S	V	N	P	F	R	D	L	G	I	Y	T	N	A	V	L	E	S	Y	K	G	K	N	R	L	E	V	P	P	H	V	F	A	I	A	E	S	M	Y	Y	N	L	K	S	Y	N
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	E	N	Q	C	V	I	I	S	G	E	S	G	A	G	K	T	E	A	A	K	R	I	M	Q	Y	I	A	A	A	S	N	S	H	S	E	S	I	G	K	I	K	D	M	V	L	A	T	N	P	L	L	E	S	F	G	C	A	K	T	L
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	R	N	N	N	S	S	R	H	G	K	Y	L	E	I	K	F	N	S	Q	F	E	P	C	A	G	N	I	T	N	Y	L	L	E	K	Q	R	V	V	G	Q	I	K	N	E	R	N	F	H	I	F	Y	Q	F	T	K	G	A	S	D	T
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	Y	K	Q	M	F	G	V	Q	M	P	E	Q	Y	I	Y	T	A	A	A	G	C	T	T	A	D	T	I	D	D	V	K	D	Y	E	G	T	L	E	A	M	R	T	I	G	L	V	Q	E	E	Q	D	Q	I	F	R	M	L	A	A	I
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?		?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	L	W	I	G	N	I	S	F	I	E	N	E	E	G	N	A	Q	V	G	D	T	S	V	T	D	F	V	A	Y	L	L	Q	V	D	A	S	L	L	V	K	C	L	V	E	R	I	M	Q	T	S	H	G	M	K	R	G	S	V	Y	H
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?																														?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	V	P	L	N	P	V	Q	A	T	A	V	R	D	A	L	A	K	A	I	Y	N	N	L	F	D	W	I	V	D	R	V	N	V	S	L	Q	A	F	P	G	A	D	K	S	I	G	I	L	D	I	Y	G	F	E	I	F	E	H	N	S
Secondary structure
SS confidence
Disorder																																						?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	F	E	Q	I	C	I	N	Y	V	N	E	K	L	Q	Q	I	F	I	Q	L	T	L	K	A	E	Q	E	T	Y	E	R	E	K	I	K	W	T	P	I	K	Y	F	D	N	K	V	V	C	D	L	I	E	A	K	N	P	P	G	I	L
Secondary structure
SS confidence
Disorder																																?	?																						?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	A	A	M	N	D	S	I	A	T	A	H	A	D	S	N	A	A	D	Q	A	F	A	Q	R	L	N	L	F	N	S	N	P	Y	F	E	L	R	A	N	K	F	V	I	K	H	Y	A	G	D	V	T	Y	D	I	N	G	I	T	D	K
Secondary structure
SS confidence
Disorder										?		?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	N	K	D	Q	L	Q	K	D	L	I	E	L	I	G	T	T	T	N	T	F	L	S	T	I	F	P	D	D	V	D	K	D	S	K	R	R	P	P	T	A	G	D	K	I	I	K	S	A	N	E	L	V	E	T	L	S	K	A	E	P
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	S	Y	I	R	T	I	K	P	N	Q	T	K	S	P	N	D	Y	D	D	H	Q	V	L	H	Q	V	K	Y	L	G	L	Q	E	N	V	R	I	R	R	A	G	F	A	Y	R	Q	T	F	E	K	F	V	E	R	F	Y	L	L	S	P
Secondary structure
SS confidence
Disorder											?		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	D	C	S	Y	A	G	D	Y	T	W	D	G	D	T	L	E	A	V	K	L	I	L	R	D	A	M	I	P	E	K	E	F	Q	L	G	V	T	S	V	F	I	K	T	P	E	S	L	F	A	L	E	D	M	R	D	K	Y	W	Y	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	M	A	A	R	I	Q	R	A	W	R	R	F	L	Q	R	R	I	D	A	A	I	K	I	Q	R	T	I	R	E	K	K	G	G	N	K	Y	V	K	L	R	D	Y	G	T	K	L	L	A	G	K	K	E	R	R	S	M	S	L	L	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Y	R	A	F	M	G	D	Y	L	S	C	N	E	S	K	T	K	G	S	Y	I	R	R	Q	V	G	I	K	D	K	V	V	F	S	I	K	G	E	C	L	H	S	K	F	G	R	S	A	Q	R	L	K	K	V	F	I	L	T	K	K
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	T	F	Y	I	I	G	Q	T	R	E	Q	N	A	M	K	Y	T	Q	D	Y	K	I	D	V	G	K	I	K	Q	V	S	L	T	N	L	Q	D	D	W	M	G	V	I	L	V	N	S	T	Q	S	D	P	L	I	N	T	P	F	K	T
Secondary structure
SS confidence
Disorder																					?								?	?	?	?	?	?	?	?	?									?	?		?	?			?					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	E	L	M	T	R	L	K	K	L	N	E	K	I	M	I	K	V	G	P	T	I	E	Y	H	K	Q	P	N	K	L	H	T	V	R	S	K	I	S	D	S	A	P	K	Y	G	D	I	Y	K	S	S	T	I	Y	V	R	R	G	H	P
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	A	N	S	K	S	N	K	K	P	K	N	P	G	G	L	S	G	K	P	I	K	S	K	K	S	K	H	K	S	T	H	K	H	T	H	S	H	R	S	H	R	D	A	A	K	K	Q	P	L	P	S	Q	K	P	V	N	P	L	S	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	A	A	T	A	A	Q	A	A	Y	N	P	K	P	D	K	T	V	P	I	K	S	S	A	I	P	A	A	K	V	S	S	K	H	S	S	K	P	S	S	K	E	K	V	A	V	K	K	A	S	S	S	H	K	S	S	S	A	K	Q	N
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	Q	V	S	M	P	P	S	K	G	V	E	K	N	K	E	P	L	K	E	T	T	A	T	A	T	A	N	I	P	I	P	P	P	P	P	P	M	G	Q	P	K	D	P	K	F	E	A	A	Y	D	F	P	G	S	G	S	S	S	E	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	P	L	K	K	G	D	I	V	F	I	S	R	D	E	P	S	G	W	S	L	A	K	L	L	D	G	S	K	E	G	W	V	P	T	A	Y	M	T	P	Y	K	D	T	R	N	T	V	P	V	A	A	T	G	A	V	N	D	V	T	N
Secondary structure
SS confidence
Disorder	?														?	?							?	?	?	?	?	?	?										?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	Q	K	S	S	Q	I	D	N	T	I	S	S	A	Q	E	G	V	Q	F	G	S	A	T	V	G	P	T	S	D	N	Q	S	N	P	V	G	T	F	S	D	G	L	A	S	A	L	A	A	R	A	N	K	M	R	A	E	S	A	D	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?											?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.
Sequence	D	D	N	D	D	G	D	D	D	D	D	W
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence