Phyre 2 Results for A2A5R2

Email	l.a.kelley@imperial.ac.uk
Description	A2A5R2
Date	Wed Jul 10 14:14:35 BST 2013
Unique Job ID	2603581db20acf58
Sequence	MQESQTKSMF ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:64.851 Y:48.325 Z:45.439

Model (left) based on template d1pbva_

Top template information

Fold:alpha-alpha superhelix
Superfamily:Sec7 domain
Family:Sec7 domain

Confidence and coverage

Confidence:

100.0%

Coverage:

11%

193 residues ( 11% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1002 residues ( 56%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M Q E S Q T K S M F V S R A L E K I L A D K E V K R P Q H S Q L R R A C Q V A L D E I K A E L E K Q R L G A A A P P K A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence N F I E A D K Y F L P F E L A C Q S K S P R V V S T S L D C L Q K L I A Y G H I T G N A P D S G A P G K R L I D R I V E

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence T I C N C F Q G P Q T D E G V Q L Q I I K A L L T A V T S P H I E I H E G T I L Q T V R T C Y N I Y L A S K N L I N Q T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence T A K A T L T Q M L N V I F T R M E N Q V L Q E A R E L E K P M Q S K P Q S P V I Q A T A G S P K F S R L K Q S Q A Q S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence K P T T P E K A E L P N G D H A Q S G L G K V S L E N G E A P R E R G S P V S G R A E P S R G T D S G A Q E V V K D I L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E D V V T S A V K E A A E K H G L P E P D R A L G A L E C Q E C A V P P G V D E N S Q T N G I A D D R Q S L S S A D N L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence E P D V Q G H Q V A A R F S H I L Q K D A F L V F R S L C K L S M K P L G E G P P D P K S H E L R S K V V S L Q L L L S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence V L Q N A G P V F R S H E M F V T A I K Q Y L C V A L S K N G V S S V P D V F E L S L A I F L T L L S N F K M H L K M Q

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence I E V F F K E I F L N I L E T S T S S F E H R W M V I Q T L T R I C A D A Q C V V D I Y V N Y D C D L N A A N I F E R L

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence V N D L S K I A Q G R S G H E L G M T P L Q E L S L R K K G L E C L V S I L K C M V E W S K D L Y V N P N H Q A T L G Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
?
? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence E R L P D Q E M G D G K G L D M A R R C S V T S V E S T V S S G T Q T A I Q D D P E Q F E V I K Q Q K E I I E H G I E L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence F N K K P K R G I Q F L Q E Q G M L G A A V E D I A Q F L H Q E E R L D S T Q V G E F L G D S T R F N K E V M Y A Y V D

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence Q L D F C E K E F V S A L R T F L E G F R L P G E A Q K I D R L M E K F A A R Y I E C N Q G Q T L F A S A D T A Y V L A

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Y S I I M L T T D L H S P Q V K N K M T K E Q Y I K M N R G I N D S K D L P E E Y L S S I Y D E I E G K K I A M K E T K

Secondary structure

SS confidence

Disorder
?
?
? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence E H T I A T K S T K Q S V A S E K Q R R L L Y N V E M E Q M A K T A K A L M E A V S H A K A P F T S A T H L D H V R P M

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence F K L V W T P L L A A Y S I G L Q N C D D T E V A S L C L E G I R C A V R I A C I F G M Q L E R D A Y V Q A L A R F S L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence L T A S S S I T E M K Q K N I D T I K T L I T V A H T D G N Y L G N S W H E I L K C I S Q L E L A Q L I G T G V K T R Y

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence L S G S G R E R E G S L K G H S L A G E E F M G L G L G N L V S G G V D K R Q M A S F Q E S V G E T S S Q S V V V A V D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence R I F T G S T R L D G N A I V D F V R W L C A V S M D E L A S P H H P R M F S L Q K I V E I S Y Y N M N R I R L Q W S R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence I W H V I G D H F N K V G C N P N E D V A I F A V D S L R Q L S M K F L E K G E L A N F R F Q K D F L R P F E H I M K K

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence N R S P T I R D M V I R C I A Q M V S S Q A A N I R S G W K N I F A V F H Q A A S D H D G N I V E L A F Q T T G H I V S

Secondary structure

SS confidence

Disorder ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence T I F Q H H F P A A I D S F Q D A V K C L S E F A C N A A F P D T S M E A I R L I R F C G K Y V S E R P R V L Q E Y T S

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence D D M N V A P G D R V W V R G W F P I L F E L S C I I N R C K L D V R T R G L T V M F E I M K S Y G H T F A K H W W Q D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence L F R I V F R I F D N M K L P E Q Q S E K S E W M T T T C N H A L Y A I C D V F T Q F Y E A L H E V L L S D V F A Q L Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence W C V K Q D N E Q L A R S G T N C L E N L V I S N G E K F S P A V W D E T C N C M L D I F K T T I P H V L L T W R P A G

Secondary structure

SS confidence

Disorder
?
? ? ? ?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . . . . . 1530 . . . . . . . . . 1540 . . . . . . . . . 1550 . . . . . . . . . 1560

Sequence M E E E V S D R H L D V D L D R Q S L S S I D R N A S E R G Q S Q L S N P T D D S W K G A P Y A H Q K L L A S L L I K C

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1570 . . . . . . . . . 1580 . . . . . . . . . 1590 . . . . . . . . . 1600 . . . . . . . . . 1610 . . . . . . . . . 1620

Sequence V V Q L E L I Q T I D N I V F Y P A T S K K E D A E H M V A A Q Q D T L D A E I H I E T E N Q G M Y K F M S S Q H L F K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1630 . . . . . . . . . 1640 . . . . . . . . . 1650 . . . . . . . . . 1660 . . . . . . . . . 1670 . . . . . . . . . 1680

Sequence L L D C L Q E S H S F S K A F N S N Y E Q R T V L W R A G F K G K S K P N L L K Q E T S S L A C C L R I L F R M Y V D E

Secondary structure

SS confidence

Disorder
? ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 1690 . . . . . . . . . 1700 . . . . . . . . . 1710 . . . . . . . . . 1720 . . . . . . . . . 1730 . . . . . . . . . 1740

Sequence N R R D S W D E I Q Q R L L R V C S E A L A Y F I T V N S E S H R E A W T S L L L L L L T K T L K I S D E K F K A H A S

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 1750 . . . . . . . . . 1760 . . . . . . . . . 1770 . . . . . . . . . 1780 . . . . . . . . . 1790 . .

Sequence M Y Y P Y L C E I M Q F D L I P E L R A V L R K F F L R I G L V Y K I W I P E E P S Q V P A A L S S T W

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 33%)

Alpha helix ( 62%)

Beta strand ( 0%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1pbv chain A

Region: 643 - 837
Aligned: 193
Modelled: 195
Confidence: 100.0%
Identity: 46%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 2r09 chain A

Region: 648 - 850
Aligned: 201
Modelled: 203
Confidence: 100.0%
Identity: 45%
PDB header:signaling protein
Chain: A: PDB Molecule:cytohesin-3;
PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor

Phyre2

PDB 1ku1 chain A

Region: 648 - 837
Aligned: 188
Modelled: 190
Confidence: 100.0%
Identity: 37%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 1bc9 chain A

Region: 646 - 843
Aligned: 196
Modelled: 198
Confidence: 100.0%
Identity: 49%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 2r09 chain A domain 1

Region: 649 - 838
Aligned: 188
Modelled: 190
Confidence: 100.0%
Identity: 48%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 1re0 chain B

Region: 645 - 840
Aligned: 191
Modelled: 196
Confidence: 100.0%
Identity: 38%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 1r8s chain E

Region: 652 - 839
Aligned: 186
Modelled: 188
Confidence: 100.0%
Identity: 49%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 1xsz chain A domain 1

Region: 648 - 837
Aligned: 188
Modelled: 190
Confidence: 100.0%
Identity: 40%
Fold: alpha-alpha superhelix
Superfamily: Sec7 domain
Family: Sec7 domain

Phyre2

PDB 1xsz chain A

Region: 649 - 843
Aligned: 193
Modelled: 195
Confidence: 100.0%
Identity: 38%
PDB header:signaling protein
Chain: A: PDB Molecule:guanine nucleotide exchange protein;
PDBTitle: the structure of ralf

Phyre2

PDB 3l8n chain A

Region: 648 - 835
Aligned: 178
Modelled: 188
Confidence: 100.0%
Identity: 92%
PDB header:nucleotide-binding protein, metal-bindin
Chain: A: PDB Molecule:brefeldin a-inhibited guanine nucleotide-exchange
PDBTitle: crystal structure of a domain of brefeldin a-inhibited2 guanine nucleotide-exchange protein 2 (brefeldina-inhibited3 gep 2) from homo sapiens (human). northeast structural4 genomics consortium target id hr5562a

Phyre2

PDB 1u6g chain C

Region: 1147 - 1481
Aligned: 285
Modelled: 315
Confidence: 98.1%
Identity: 13%
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Family: HEAT repeat

Phyre2

PDB 1m5n chain S

Region: 1142 - 1468
Aligned: 311
Modelled: 327
Confidence: 97.4%
Identity: 13%
PDB header:protein transport
Chain: S: PDB Molecule:importin beta-1 subunit;
PDBTitle: crystal structure of heat repeats (1-11) of importin b2 bound to the non-classical nls(67-94) of pthrp

Phyre2

PDB 4a0c chain B

Region: 1090 - 1470
Aligned: 355
Modelled: 381
Confidence: 97.1%
Identity: 12%
PDB header:cell cycle
Chain: B: PDB Molecule:cullin-associated nedd8-dissociated protein 1;
PDBTitle: structure of the cand1-cul4b-rbx1 complex

Phyre2

PDB 2bpt chain A domain 1

Region: 1087 - 1774
Aligned: 609
Modelled: 635
Confidence: 96.9%
Identity: 11%
Fold: alpha-alpha superhelix
Superfamily: ARM repeat
Family: Armadillo repeat

Phyre2

PDB 2qk1 chain A

Region: 1149 - 1370
Aligned: 201
Modelled: 206
Confidence: 96.8%
Identity: 13%
PDB header:protein binding
Chain: A: PDB Molecule:protein stu2;
PDBTitle: structural basis of microtubule plus end tracking by2 xmap215, clip-170 and eb1

Phyre2

PDB 4k92 chain B

Region: 1155 - 1370
Aligned: 184
Modelled: 197
Confidence: 96.5%
Identity: 7%
PDB header:structural protein
Chain: B: PDB Molecule:clip-associating protein 1;
PDBTitle: a cryptic tog domain with a distinct architecture underlies clasp-2 dependent bipolar spindle formation

Phyre2

PDB 4ffb chain C

Region: 1193 - 1439
Aligned: 203
Modelled: 222
Confidence: 96.4%
Identity: 11%
PDB header:hydrolase
Chain: C: PDB Molecule:protein stu2;
PDBTitle: a tog:alpha/beta-tubulin complex structure reveals conformation-based2 mechanisms for a microtubule polymerase

Phyre2

PDB 2qk2 chain A

Region: 1149 - 1370
Aligned: 189
Modelled: 202
Confidence: 96.2%
Identity: 12%
PDB header:protein binding
Chain: A: PDB Molecule:lp04448p;
PDBTitle: structural basis of microtubule plus end tracking by xmap215, clip-1702 and eb1

Phyre2

PDB 3b2a chain A

Region: 1147 - 1367
Aligned: 183
Modelled: 199
Confidence: 96.1%
Identity: 9%
PDB header:unknown function
Chain: A: PDB Molecule:putative uncharacterized protein;
PDBTitle: crystal structure of the archaeal heat-like repeats protein ton_19372 from thermococcus onnurineus na1

Phyre2

PDB 4g3a chain A

Region: 1149 - 1393
Aligned: 208
Modelled: 224
Confidence: 95.9%
Identity: 13%
PDB header:cell cycle
Chain: A: PDB Molecule:clip-associating protein;
PDBTitle: crystal structure of mast/orbit n-terminal domain

Phyre2

PDB 3w3z chain A

Region: 905 - 1772
Aligned: 716
Modelled: 696
Confidence: 93.7%
Identity: 11%
PDB header:protein transport/nuclear protein
Chain: A: PDB Molecule:importin subunit beta-3;
PDBTitle: crystal structure of kap121p bound to rangtp

Phyre2

PDB 2qna chain A

Region: 443 - 1471
Aligned: 706
Modelled: 706
Confidence: 57.7%
Identity: 12%
PDB header:transport protein
Chain: A: PDB Molecule:importin subunit beta-1;
PDBTitle: crystal structure of human importin-beta (127-876) in complex with the2 ibb-domain of snurportin1 (1-65)

Phyre2

100

101

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	Q	E	S	Q	T	K	S	M	F	V	S	R	A	L	E	K	I	L	A	D	K	E	V	K	R	P	Q	H	S	Q	L	R	R	A	C	Q	V	A	L	D	E	I	K	A	E	L	E	K	Q	R	L	G	A	A	A	P	P	K	A
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																		?	?	?	?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	N	F	I	E	A	D	K	Y	F	L	P	F	E	L	A	C	Q	S	K	S	P	R	V	V	S	T	S	L	D	C	L	Q	K	L	I	A	Y	G	H	I	T	G	N	A	P	D	S	G	A	P	G	K	R	L	I	D	R	I	V	E
Secondary structure
SS confidence
Disorder	?	?	?	?														?	?	?																								?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	T	I	C	N	C	F	Q	G	P	Q	T	D	E	G	V	Q	L	Q	I	I	K	A	L	L	T	A	V	T	S	P	H	I	E	I	H	E	G	T	I	L	Q	T	V	R	T	C	Y	N	I	Y	L	A	S	K	N	L	I	N	Q	T
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?																			?																								?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	T	A	K	A	T	L	T	Q	M	L	N	V	I	F	T	R	M	E	N	Q	V	L	Q	E	A	R	E	L	E	K	P	M	Q	S	K	P	Q	S	P	V	I	Q	A	T	A	G	S	P	K	F	S	R	L	K	Q	S	Q	A	Q	S
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	K	P	T	T	P	E	K	A	E	L	P	N	G	D	H	A	Q	S	G	L	G	K	V	S	L	E	N	G	E	A	P	R	E	R	G	S	P	V	S	G	R	A	E	P	S	R	G	T	D	S	G	A	Q	E	V	V	K	D	I	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	D	V	V	T	S	A	V	K	E	A	A	E	K	H	G	L	P	E	P	D	R	A	L	G	A	L	E	C	Q	E	C	A	V	P	P	G	V	D	E	N	S	Q	T	N	G	I	A	D	D	R	Q	S	L	S	S	A	D	N	L
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	E	P	D	V	Q	G	H	Q	V	A	A	R	F	S	H	I	L	Q	K	D	A	F	L	V	F	R	S	L	C	K	L	S	M	K	P	L	G	E	G	P	P	D	P	K	S	H	E	L	R	S	K	V	V	S	L	Q	L	L	L	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?																				?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	V	L	Q	N	A	G	P	V	F	R	S	H	E	M	F	V	T	A	I	K	Q	Y	L	C	V	A	L	S	K	N	G	V	S	S	V	P	D	V	F	E	L	S	L	A	I	F	L	T	L	L	S	N	F	K	M	H	L	K	M	Q
Secondary structure
SS confidence
Disorder																															?			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	I	E	V	F	F	K	E	I	F	L	N	I	L	E	T	S	T	S	S	F	E	H	R	W	M	V	I	Q	T	L	T	R	I	C	A	D	A	Q	C	V	V	D	I	Y	V	N	Y	D	C	D	L	N	A	A	N	I	F	E	R	L
Secondary structure
SS confidence
Disorder															?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	V	N	D	L	S	K	I	A	Q	G	R	S	G	H	E	L	G	M	T	P	L	Q	E	L	S	L	R	K	K	G	L	E	C	L	V	S	I	L	K	C	M	V	E	W	S	K	D	L	Y	V	N	P	N	H	Q	A	T	L	G	Q
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?		?																										?	?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	E	R	L	P	D	Q	E	M	G	D	G	K	G	L	D	M	A	R	R	C	S	V	T	S	V	E	S	T	V	S	S	G	T	Q	T	A	I	Q	D	D	P	E	Q	F	E	V	I	K	Q	Q	K	E	I	I	E	H	G	I	E	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	F	N	K	K	P	K	R	G	I	Q	F	L	Q	E	Q	G	M	L	G	A	A	V	E	D	I	A	Q	F	L	H	Q	E	E	R	L	D	S	T	Q	V	G	E	F	L	G	D	S	T	R	F	N	K	E	V	M	Y	A	Y	V	D
Secondary structure
SS confidence
Disorder																																		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	Q	L	D	F	C	E	K	E	F	V	S	A	L	R	T	F	L	E	G	F	R	L	P	G	E	A	Q	K	I	D	R	L	M	E	K	F	A	A	R	Y	I	E	C	N	Q	G	Q	T	L	F	A	S	A	D	T	A	Y	V	L	A
Secondary structure
SS confidence
Disorder						?																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Y	S	I	I	M	L	T	T	D	L	H	S	P	Q	V	K	N	K	M	T	K	E	Q	Y	I	K	M	N	R	G	I	N	D	S	K	D	L	P	E	E	Y	L	S	S	I	Y	D	E	I	E	G	K	K	I	A	M	K	E	T	K
Secondary structure
SS confidence
Disorder									?				?		?	?	?																?																										?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	E	H	T	I	A	T	K	S	T	K	Q	S	V	A	S	E	K	Q	R	R	L	L	Y	N	V	E	M	E	Q	M	A	K	T	A	K	A	L	M	E	A	V	S	H	A	K	A	P	F	T	S	A	T	H	L	D	H	V	R	P	M
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?							?	?	?	?	?	?	?								?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	F	K	L	V	W	T	P	L	L	A	A	Y	S	I	G	L	Q	N	C	D	D	T	E	V	A	S	L	C	L	E	G	I	R	C	A	V	R	I	A	C	I	F	G	M	Q	L	E	R	D	A	Y	V	Q	A	L	A	R	F	S	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	L	T	A	S	S	S	I	T	E	M	K	Q	K	N	I	D	T	I	K	T	L	I	T	V	A	H	T	D	G	N	Y	L	G	N	S	W	H	E	I	L	K	C	I	S	Q	L	E	L	A	Q	L	I	G	T	G	V	K	T	R	Y
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?																																						?	?					?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	L	S	G	S	G	R	E	R	E	G	S	L	K	G	H	S	L	A	G	E	E	F	M	G	L	G	L	G	N	L	V	S	G	G	V	D	K	R	Q	M	A	S	F	Q	E	S	V	G	E	T	S	S	Q	S	V	V	V	A	V	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	R	I	F	T	G	S	T	R	L	D	G	N	A	I	V	D	F	V	R	W	L	C	A	V	S	M	D	E	L	A	S	P	H	H	P	R	M	F	S	L	Q	K	I	V	E	I	S	Y	Y	N	M	N	R	I	R	L	Q	W	S	R
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	I	W	H	V	I	G	D	H	F	N	K	V	G	C	N	P	N	E	D	V	A	I	F	A	V	D	S	L	R	Q	L	S	M	K	F	L	E	K	G	E	L	A	N	F	R	F	Q	K	D	F	L	R	P	F	E	H	I	M	K	K
Secondary structure
SS confidence
Disorder															?																						?	?	?	?	?	?	?														?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	N	R	S	P	T	I	R	D	M	V	I	R	C	I	A	Q	M	V	S	S	Q	A	A	N	I	R	S	G	W	K	N	I	F	A	V	F	H	Q	A	A	S	D	H	D	G	N	I	V	E	L	A	F	Q	T	T	G	H	I	V	S
Secondary structure
SS confidence
Disorder	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	T	I	F	Q	H	H	F	P	A	A	I	D	S	F	Q	D	A	V	K	C	L	S	E	F	A	C	N	A	A	F	P	D	T	S	M	E	A	I	R	L	I	R	F	C	G	K	Y	V	S	E	R	P	R	V	L	Q	E	Y	T	S
Secondary structure
SS confidence
Disorder																														?	?	?	?																	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	D	D	M	N	V	A	P	G	D	R	V	W	V	R	G	W	F	P	I	L	F	E	L	S	C	I	I	N	R	C	K	L	D	V	R	T	R	G	L	T	V	M	F	E	I	M	K	S	Y	G	H	T	F	A	K	H	W	W	Q	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?																																								?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	L	F	R	I	V	F	R	I	F	D	N	M	K	L	P	E	Q	Q	S	E	K	S	E	W	M	T	T	T	C	N	H	A	L	Y	A	I	C	D	V	F	T	Q	F	Y	E	A	L	H	E	V	L	L	S	D	V	F	A	Q	L	Q
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	W	C	V	K	Q	D	N	E	Q	L	A	R	S	G	T	N	C	L	E	N	L	V	I	S	N	G	E	K	F	S	P	A	V	W	D	E	T	C	N	C	M	L	D	I	F	K	T	T	I	P	H	V	L	L	T	W	R	P	A	G
Secondary structure
SS confidence
Disorder																								?																																	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.	.	.	.	1530	.	.	.	.	.	.	.	.	.	1540	.	.	.	.	.	.	.	.	.	1550	.	.	.	.	.	.	.	.	.	1560
Sequence	M	E	E	E	V	S	D	R	H	L	D	V	D	L	D	R	Q	S	L	S	S	I	D	R	N	A	S	E	R	G	Q	S	Q	L	S	N	P	T	D	D	S	W	K	G	A	P	Y	A	H	Q	K	L	L	A	S	L	L	I	K	C
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1570	.	.	.	.	.	.	.	.	.	1580	.	.	.	.	.	.	.	.	.	1590	.	.	.	.	.	.	.	.	.	1600	.	.	.	.	.	.	.	.	.	1610	.	.	.	.	.	.	.	.	.	1620
Sequence	V	V	Q	L	E	L	I	Q	T	I	D	N	I	V	F	Y	P	A	T	S	K	K	E	D	A	E	H	M	V	A	A	Q	Q	D	T	L	D	A	E	I	H	I	E	T	E	N	Q	G	M	Y	K	F	M	S	S	Q	H	L	F	K
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1630	.	.	.	.	.	.	.	.	.	1640	.	.	.	.	.	.	.	.	.	1650	.	.	.	.	.	.	.	.	.	1660	.	.	.	.	.	.	.	.	.	1670	.	.	.	.	.	.	.	.	.	1680
Sequence	L	L	D	C	L	Q	E	S	H	S	F	S	K	A	F	N	S	N	Y	E	Q	R	T	V	L	W	R	A	G	F	K	G	K	S	K	P	N	L	L	K	Q	E	T	S	S	L	A	C	C	L	R	I	L	F	R	M	Y	V	D	E
Secondary structure
SS confidence
Disorder																												?	?	?	?		?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1690	.	.	.	.	.	.	.	.	.	1700	.	.	.	.	.	.	.	.	.	1710	.	.	.	.	.	.	.	.	.	1720	.	.	.	.	.	.	.	.	.	1730	.	.	.	.	.	.	.	.	.	1740
Sequence	N	R	R	D	S	W	D	E	I	Q	Q	R	L	L	R	V	C	S	E	A	L	A	Y	F	I	T	V	N	S	E	S	H	R	E	A	W	T	S	L	L	L	L	L	L	T	K	T	L	K	I	S	D	E	K	F	K	A	H	A	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?																										?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1750	.	.	.	.	.	.	.	.	.	1760	.	.	.	.	.	.	.	.	.	1770	.	.	.	.	.	.	.	.	.	1780	.	.	.	.	.	.	.	.	.	1790	.	.
Sequence	M	Y	Y	P	Y	L	C	E	I	M	Q	F	D	L	I	P	E	L	R	A	V	L	R	K	F	F	L	R	I	G	L	V	Y	K	I	W	I	P	E	E	P	S	Q	V	P	A	A	L	S	S	T	W
Secondary structure
SS confidence
Disorder													?																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence