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Job DescriptionA2A5R2
Confidence57.73%DateWed Jul 10 14:14:35 BST 2013
Rank55Aligned Residues706
% Identity12%Templatec2qnaA_
PDB info PDB header:transport proteinChain: A: PDB Molecule:importin subunit beta-1; PDBTitle: crystal structure of human importin-beta (127-876) in complex with the2 ibb-domain of snurportin1 (1-65)
Resolution2.84 Å
Model Dimensions (Å)X:88.127 Y:95.234 Z:58.599

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   443......450..... ....460.........470.........480.........490.........500
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Query Sequence  LCVALSKNGVSSV. . PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSF
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Template Sequence  LIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSN
Template Known Secondary structure 
TT

TTS
STT


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   129130.........140.........150.........160.........170.........180........
 
   501........510.........520.........530.........540.........550.........560
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Query Sequence  EHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTP
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Template Sequence  NVKLAATNALLNSLEFTKANFD. . . . . . . . . . KESERHFIMQVVCEATQCPD. . . . . . . .
Template Known Secondary structure  GGG
..........STT
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   189190.........200.........210 .........220.........230
 
   561........570.........580.........590.........600.........610.........620
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Query Sequence  LQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRC
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Template Sequence  . . . TRVRVAALQNLVKIMSLYYQYMETYMGPAL. . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ...
STT

GGG...........................
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   231........240.........250.........260
 
   621........630.........640.........650.........660.........670.........680
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Query Sequence  SVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGA
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Template Conservation  ............................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
Template Predicted Secondary structure  ............................................................
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   681........690.........700.........710.........720.........730.........740
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Query Sequence  AVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGF
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Template Conservation  ................   
          
   
      
                  
Template Sequence  . . . . . . . . . . . . . . . . FAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQG
Template Known Secondary structure  ................T
SST
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   261........270.........280.........290.........300....
 
   741.... ....750.........760.........770.........780.........790....
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Query Sequence  RLPGE. . . . . . AQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQ
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Template Conservation                       
   
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Template Sequence  RPPEHTSKFYAKGALQYLVPILTQTLTKQDEN. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure 


SS



TT


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   305....310.........320.........330......
 
   795....800.........810.........820.........830.........840.........850....
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Query Sequence  VKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVA
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Template Conservation  ................                     .......................
Template Sequence  . . . . . . . . . . . . . . . . DDDDDWNPCKAAGVCLMLLAT. . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ................

SS


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   337..340.........350.......
 
   855....860.........870.........880.........890.........900.........910....
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Query Sequence  SEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSI
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Template Conservation  .............................................               
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CCEDDIVPHVLPFIK
Template Known Secondary structure  .............................................GGGG
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   358.360.........370..
 
   915....920.........930.........940.........950.........960.........970....
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Query Sequence  GLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKN
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Template Conservation                   
                      
   
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Template Sequence  EHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMK. . . . DPSVVVRDTA
Template Known Secondary structure  TT
SSTSSSS
T....
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   373......380.........390.........400.........410........ .420........
 
   975....980... ......990.........1000.........1010.........1020
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Query Sequence  IDTIKTLIT. . . . . . . . . . . . . . VAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRY
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Template Sequence  AWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLA. . . . . . . . . .
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S
TTTTTS
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   429430.........440.........450.........460.........470........
 
   1021........1030.........1040.........1050.........1060.........1070.........1080
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Query Sequence  LSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVD
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Template Conservation  .................................................           
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EAAYEAADVAD
Template Known Secondary structure  .................................................S


T
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   479480.........
 
   1081........1090.........1100.........1110.........1120.........1130.........1140
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Query Sequence  RIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSR
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Template Conservation                      
                     
                 
Template Sequence  DQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQK
Template Known Secondary structure  T
SS
S

TTT
TTTTGGGS

GGG
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   490.........500.........510.........520.........530.........540.........
 
   1141........1150.........1160.........1170.........1180.........1190.........1200
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Query Sequence  IWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKK
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Template Conservation      
   
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Template Sequence  TTLVIMERLQQVLQ. MFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASL. . LRMFQST
Template Known Secondary structure  TT.


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   550.........560... ......570.........580.........590......... 600......
 
   1201........1210.........1220........ .1230.........1240.........1250.........
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Query Sequence  NRSPTIRDMVIRCIAQMVSSQAANIRSG. WKNIFAVFHQAASDHDGNIVELAFQTTGHIV
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Template Conservation                                     
   
               
  
 
Template Sequence  AGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLC
Template Known Secondary structure 


GGGGGGG

SS
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   619620.........630.........640.........650.........660.........670........
 
   1260.........1270.........1280.........1290.........1300.........1310.........
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Query Sequence  STIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYT
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Template Sequence  RALQSNIIPFCDEVMQLLLENLGN. . . ENVHRSVKPQILSVFGDIALAI. . . . . . . . . . .
Template Known Secondary structure  GGGG
...TTS
TT...........
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   679680.........690.........700.. .......710.........720....
 
   1320.........1330.........1340.........1350. ........1360.........1370.
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Query Sequence  SDDMNVAPGDRVWVRGWFPILFELSCIINRCK. . . . . . . . LDVRTRGLTVMFEIMKSYGH
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Template Conservation  ......           
  
                                 
  
  
Template Sequence  . . . . . . GGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKG
Template Known Secondary structure  ......GGGGT



SS

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   725....730.........740.........750.........760.........770........
 
   1372.. .....1380.........1390.........1400.........1410.........1420.........
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Query Sequence  TFA. . KHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHE
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Template Conservation                                             
  
             
Template Sequence  DQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVE
Template Known Secondary structure  SSSS

GGGGGTGGG
TT


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   779780.........790.........800.........810.........820.........830........
 
   1430.........1440.........1450.........1460.........1470.
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Query Sequence  VLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSP
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Template Conservation   .   
  

     
 
   
  
  
              
Template Sequence  A. RPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQGLTR
Template Known Secondary structure  T.ST
SSTT


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   839 840.........850.........860.........870.........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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