PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3zyqA_

Fold library id	PDB Header	Molecule	Title
c3zyqA_	PDB header: signaling	Chain: A: PDB Molecule: hepatocyte growth factor-regulated tyrosine kinase	PDBTitle: crystal structure of the tandem vhs and fyve domains of hepatocyte2 growth factor-regulated tyrosine kinase substrate (hgs-hrs) at 1.483 a resolution

Links to external resources
Added to library: Sat Sep 10 12:37:33 2011

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G T F E R L L D K A T S Q L L L E T D W E S I L Q I C D L I R Q G D T Q A K Y A V N S I K K K V N D K N P H V A L Y A L E V M E S V V K N C

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T
T T
S S
T T S S
T
S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence G Q T V H D E V A N K Q T M E E L K D L L K R Q V E V N V R N K I L Y L I Q A W A H A F R N E P K Y K V V Q D T Y Q I M K V E G H V F P E F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T T
G G G T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence K E S D A M F A A E R A P D W V D A E E C H R C R V Q F G V M T R K H H C R A C G Q I F C G K C S S K Y S T I P K F G I E K E V R V C E P C

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G G
S B
T T T
B
B T T B
T T T
T T T
G G G T

. . . . . .

Sequence Y E Q L N R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	T	F	E	R	L	L	D	K	A	T	S	Q	L	L	L	E	T	D	W	E	S	I	L	Q	I	C	D	L	I	R	Q	G	D	T	Q	A	K	Y	A	V	N	S	I	K	K	K	V	N	D	K	N	P	H	V	A	L	Y	A	L	E	V	M	E	S	V	V	K	N	C
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											T		T	T		S	S															T	T	S	S														T		S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	G	Q	T	V	H	D	E	V	A	N	K	Q	T	M	E	E	L	K	D	L	L	K	R	Q	V	E	V	N	V	R	N	K	I	L	Y	L	I	Q	A	W	A	H	A	F	R	N	E	P	K	Y	K	V	V	Q	D	T	Y	Q	I	M	K	V	E	G	H	V	F	P	E	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)									S	S																																		T	T	T		G	G	G														T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	K	E	S	D	A	M	F	A	A	E	R	A	P	D	W	V	D	A	E	E	C	H	R	C	R	V	Q	F	G	V	M	T	R	K	H	H	C	R	A	C	G	Q	I	F	C	G	K	C	S	S	K	Y	S	T	I	P	K	F	G	I	E	K	E	V	R	V	C	E	P	C
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		G	G	G	G														S	B		T	T	T			B		B	T	T	B						T	T	T						T	T	T								G	G	G	T
	.	.	.	.	.	.
Sequence	Y	E	Q	L	N	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)