PHYRE2 Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

gives you access to our Expert Mode features. Info icon

Current Phyre2 server load = 0% (normal running) Info icon

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Optional Job description
Amino Acid Sequence
or upload contents of sequence file
or UniProt accession
Modelling Mode	Normal Intensive AlphaThread Traditional Phyre2 Test mode
Please tick as appropriate.	\|NOT for Profit\| FOR Profit (Commercial)\| Other\|

Examples of running Phyre2.2 on UniProt accession P0DV45 in Normal, Intensive and AlphaThread modes Info icon

6270750 submissions since Feb 14 2011

Other Resources
Missense3D Portal:	a suite of resources for the analysis of amino acid substitutions in proteins
GWYRE:	contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) 437 168960 - 168969 DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London
Michael Sternberg
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Phyre2 is part of Genome3D