PHYRE2 Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

We are pleased to announce the release of Phyre2.2, which contains a number of new features (see the help menu for more details).

For most users, most of the time the new code will give you the answers that you need. If you really need to use the old version, checking the button below will allow this.

If you encounter any issues with the new code, please do not hesitate to get in touch

Note carefully Our webserver will be going down for scheduled maintenance on 17th December 2024. While this should not affect any running jobs, it does mean that access to Phyre2 (both for submitting new jobs and for accessing results) will be interrupted for a short time on that day.

At the moment we expect the interruption to occur around 10:30 GMT and last for about 30 minutes, but unforeseen circumstances might mean that it happens at a different time and lasts longer.

One-to-One Threading Info icon

(which models your sequence against a user-supplied model) can now use models directly from the AlphaFold Protein Structure Database Info icon

Please do not use "intensive mode" unless your search using "normal mode" indicates that a single model does not cover most of your sequence. Info icon

Current Phyre2 server load = 2% (normal running) Info icon

E-mail address:
Optional Job description
Amino Acid Sequence
or upload contents of sequence file
or UniProt accession
Modelling Mode	Normal Intensive AlphaThread Traditional Phyre2 Test mode
Please tick as appropriate.	\|NOT for Profit\| FOR Profit (Commercial)\| Other\|

Examples of running Phyre2.2 on UniProt accession P0DV45 in Normal, Intensive and AlphaThread modes Info icon

5942436 submissions since Feb 14 2011

Other Resources
Missense3D Portal:	a suite of resources for the analysis of amino acid substitutions in proteins
GWYRE:	contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement

Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

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