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 Protein Homology/analogY Recognition Engine V 2.0
 

Register so you can log in Info icon to get access to our Expert Mode features.Info icon

PLEASE NOTE CAREFULLY
Our machine running Phyre died on 5th November, so we are now using a new machine; while we think that everything will work properly, there is a possibility that there may be some teething problems.

Please bear with us in the event of any issues.

We are now using the "https" protocol for Phyre2 jobs. While you will automatically be using this, some of the submissions from this still use "http", so you will get warnings about sending data across "an insecure connection (which) could be read by a third party".

Until we have changed all the occurrences in our code to reflect the new protocol, these warnings will appear - but if you choose to continue, everything will be as secure as it always has been for your Phyre jobs.

New!
One-to-One ThreadingInfo icon (which models your sequence against a user-supplied model) can now use models directly from the AlphaFold Protein Structure DatabaseInfo icon.

Please do not use "intensive mode" unless your search using "normal mode" indicates that a single model does not cover most of your sequence. Info icon

Current Phyre2 server load = 6% (normal running) Info icon

E-mail address:
Optional Job description
or upload contents of sequence file Info icon
or UniProt accession Info icon
Modelling Mode info icon
Please tick as appropriate. info icon || | |
 

5905975 submissions since Feb 14 2011


Other Resources

Missense3D Portal: a suite of resources for the analysis of amino acid substitutions in proteins

GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper



Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
 
© Structural Bioinformatics Group, Imperial College, London
Michael Sternberg 
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