Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP77338
DateThu Jan 5 12:28:00 GMT 2012
Unique Job IDc6a9fdb8c192fa4a

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2vv5D_
Top template information
PDB header:membrane protein
Chain: D: PDB Molecule:small-conductance mechanosensitive channel;
PDBTitle: the open structure of mscs
Confidence and coverage
Confidence:100.0% Coverage: 23%
253 residues ( 23% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
744 residues ( 66%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MTMFQYYKRSRHFVFSAFIAFVFVLLCQNTAFARASSNGDLPTKADLQAQLDSLNKQKDL
Secondary structure 



















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Disorder  ??



























?????????????









???????
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   .........70.........80.........90.........100.........110.........120
Sequence  SAQDKLVQQDLTDTLATLDKIDRIKEETVQLRQKVAEAPEKMRQATAALTALSDVDNDEE
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??????????
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   .........130.........140.........150.........160.........170.........180
Sequence  TRKILSTLSLRQLETRVAQALDDLQNAQNDLASYNSQLVSLQTQPERVQNAMYNASQQLQ
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Disorder  ?????????






























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   .........190.........200.........210.........220.........230.........240
Sequence  QIRSRLDGTDVGETALRPSQKVLMQAQQALLNAEIDQQRKSLEGNTVLQDTLQKQRDYVT
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   .........250.........260.........270.........280.........290.........300
Sequence  ANSARLEHQLQLLQEAVNSKRLTLTEKTAQEAVSPDEAARIQANPLVKQELEINQQLSQR
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   .........310.........320.........330.........340.........350.........360
Sequence  LITATENGNQLMQQNIKVKNWLERALQSERNIKEQIAVLKGSLLLSRILYQQQQTLPSAD
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?????
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   .........370.........380.........390.........400.........410.........420
Sequence  ELENMTNRIADLRLEQFEVNQQRDALFQSDAFVNKLEEGHTNEVNSEVHDALLQVVDMRR
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?
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   .........430.........440.........450.........460.........470.........480
Sequence  ELLDQLNKQLGNQLMMAINLQINQQQLMSVSKNLKSILTQQIFWVNSNRPMDWDWIKAFP
Secondary structure 







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?????







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   .........490.........500.........510.........520.........530.........540
Sequence  QSLKDEFKSMKITVNWQKAWPAVFIAFLAGLPLLLIAGLIHWRLGWLKAYQQKLASAVGS
Secondary structure 


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Disorder 









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?
?

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   .........550.........560.........570.........580.........590.........600
Sequence  LRNDSQLNTPKAILIDLIRALPVCLIILAVGLILLTMQLNISELLWSFSKKLAIFWLVFG
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   .........610.........620.........630.........640.........650.........660
Sequence  LCWKVLEKNGVAVRHFGMPEQQTSHWRRQIVRISLALLPIHFWSVVAELSPLHLMDDVLG
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Disorder 






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??


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   .........670.........680.........690.........700.........710.........720
Sequence  QAMIFFNLLLIAFLVWPMCRESWRDKESHTMRLVTITVLSIIPIALMVLTATGYFYTTLR
Secondary structure 









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   .........730.........740.........750.........760.........770.........780
Sequence  LAGRWIETVYLVIIWNLLYQTVLRGLSVAARRIAWRRALARRQNLVKEGAEGAEPPEEPT
Secondary structure 








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   .........790.........800.........810.........820.........830.........840
Sequence  IALEQVNQQTLRITMLLMFALFGVMFWAIWSDLITVFSYLDSITLWHYNGTEAGAAVVKN
Secondary structure 



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?
??????????
?
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   .........850.........860.........870.........880.........890.........900
Sequence  VTMGSLLFAIIASMVAWALIRNLPGLLEVLVLSRLNMRQGASYAITTILNYIIIAVGAMT
Secondary structure 





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   .........910.........920.........930.........940.........950.........960
Sequence  VFGSLGVSWDKLQWLAAALSVGLGFGLQEIFGNFVSGLIILFERPVRIGDTVTIGSFSGT
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   .........970.........980.........990.........1000.........1010.........1020
Sequence  VSKIRIRATTITDFDRKEVIIPNKAFVTERLINWSLTDTTTRLVIRLGVAYGSDLEKVRK
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   .........1030.........1040.........1050.........1060.........1070.........1080
Sequence  VLLKAATEHPRVMHEPMPEVFFTAFGASTLDHELRLYVRELRDRSRTVDELNRTIDQLCR
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   .........1090.........1100.........1110.........1120
Sequence  ENDINIAFNQLEVHLHNEKGDEVTEVKRDYKGDDPTPAVG
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??????????????????????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2vv5 chain D

3D model

Region: 843 - 1098
Aligned: 253
Modelled: 256
Confidence: 100.0%
Identity: 22%
PDB header:membrane protein
Chain: D: PDB Molecule:small-conductance mechanosensitive channel;
PDBTitle: the open structure of mscs

Phyre2

PDB 2vv5 chain A domain 2

3D model

Region: 997 - 1097
Aligned: 100
Modelled: 101
Confidence: 99.8%
Identity: 20%
Fold: Ferredoxin-like
Superfamily: Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family: Mechanosensitive channel protein MscS (YggB), C-terminal domain

Phyre2

PDB 2vv5 chain A domain 1

3D model

Region: 930 - 995
Aligned: 66
Modelled: 66
Confidence: 99.6%
Identity: 33%
Fold: Sm-like fold
Superfamily: Sm-like ribonucleoproteins
Family: Mechanosensitive channel protein MscS (YggB), middle domain

Phyre2

PDB 2vv5 chain A domain 3

3D model

Region: 845 - 928
Aligned: 83
Modelled: 84
Confidence: 99.1%
Identity: 18%
Fold: Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily: Mechanosensitive channel protein MscS (YggB), transmembrane region
Family: Mechanosensitive channel protein MscS (YggB), transmembrane region

Phyre2

PDB 1cii chain A

3D model

Region: 39 - 566
Aligned: 491
Modelled: 497
Confidence: 99.0%
Identity: 14%
PDB header:transmembrane protein
Chain: A: PDB Molecule:colicin ia;
PDBTitle: colicin ia

Phyre2

PDB 1c1g chain A

3D model

Region: 45 - 332
Aligned: 283
Modelled: 286
Confidence: 98.3%
Identity: 12%
PDB header:contractile protein
Chain: A: PDB Molecule:tropomyosin;
PDBTitle: crystal structure of tropomyosin at 7 angstroms resolution2 in the spermine-induced crystal form

Phyre2

PDB 1sjj chain B

3D model

Region: 24 - 486
Aligned: 455
Modelled: 463
Confidence: 98.1%
Identity: 11%
PDB header:contractile protein
Chain: B: PDB Molecule:actinin;
PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin

Phyre2

PDB 1bf5 chain A

3D model

Region: 86 - 260
Aligned: 164
Modelled: 175
Confidence: 97.9%
Identity: 13%
PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex

Phyre2

PDB 1yvl chain B

3D model

Region: 46 - 331
Aligned: 280
Modelled: 281
Confidence: 97.8%
Identity: 6%
PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1

Phyre2

PDB 3oja chain B

3D model

Region: 58 - 193
Aligned: 136
Modelled: 136
Confidence: 97.6%
Identity: 8%
PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex

Phyre2

PDB 1bg1 chain A

3D model

Region: 149 - 326
Aligned: 173
Modelled: 178
Confidence: 97.5%
Identity: 10%
PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex

Phyre2

PDB 2efr chain B

3D model

Region: 81 - 233
Aligned: 152
Modelled: 153
Confidence: 97.4%
Identity: 8%
PDB header:contractile protein
Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain;
PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution

Phyre2

PDB 3dtp chain A

3D model

Region: 76 - 190
Aligned: 115
Modelled: 115
Confidence: 97.4%
Identity: 12%
PDB header:contractile protein
Chain: A: PDB Molecule:myosin 2 heavy chain chimera of smooth and
PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map

Phyre2

PDB 2oev chain A

3D model

Region: 18 - 454
Aligned: 399
Modelled: 415
Confidence: 97.3%
Identity: 13%
PDB header:protein transport
Chain: A: PDB Molecule:programmed cell death 6-interacting protein;
PDBTitle: crystal structure of alix/aip1

Phyre2

PDB 1ei3 chain C

3D model

Region: 83 - 191
Aligned: 109
Modelled: 109
Confidence: 97.3%
Identity: 8%
PDB header:
PDB COMPND:

Phyre2

PDB 3ghg chain K

3D model

Region: 72 - 186
Aligned: 113
Modelled: 115
Confidence: 97.3%
Identity: 9%
PDB header:blood clotting
Chain: K: PDB Molecule:fibrinogen beta chain;
PDBTitle: crystal structure of human fibrinogen

Phyre2

PDB 2d3e chain D

3D model

Region: 79 - 206
Aligned: 128
Modelled: 128
Confidence: 97.2%
Identity: 13%
PDB header:contractile protein
Chain: D: PDB Molecule:general control protein gcn4 and tropomyosin 1
PDBTitle: crystal structure of the c-terminal fragment of rabbit2 skeletal alpha-tropomyosin

Phyre2

PDB 3cwg chain A

3D model

Region: 44 - 203
Aligned: 160
Modelled: 160
Confidence: 97.2%
Identity: 13%
PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment

Phyre2

PDB 1ei3 chain E

3D model

Region: 74 - 186
Aligned: 111
Modelled: 113
Confidence: 97.1%
Identity: 10%
PDB header:
PDB COMPND:

Phyre2

PDB 2fxm chain B

3D model

Region: 84 - 192
Aligned: 109
Modelled: 109
Confidence: 96.9%
Identity: 13%
PDB header:contractile protein
Chain: B: PDB Molecule:myosin heavy chain, cardiac muscle beta isoform;
PDBTitle: structure of the human beta-myosin s2 fragment

Phyre2

PDB 1mhs chain A

3D model

Region: 554 - 742
Aligned: 184
Modelled: 184
Confidence: 51.2%
Identity: 9%
PDB header:membrane protein, proton transport
Chain: A: PDB Molecule:plasma membrane atpase;
PDBTitle: model of neurospora crassa proton atpase

Phyre2
1

c2vv5D_
2

d2vv5a2
3

d2vv5a1
4

d2vv5a3
5

c1ciiA_
6

c1c1gA_
7

c1sjjB_
8

c1bf5A_
9

c1yvlB_
10

c3ojaB_
11

c1bg1A_
12

c2efrB_
13

c3dtpA_
14

c2oevA_
15

c1ei3C_
16

c3ghgK_
17

c2d3eD_
18

c3cwgA_
19

c1ei3E_
20

c2fxmB_
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c1mhsA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2vv5D_



100.0 22 PDB header:membrane protein
Chain: D: PDB Molecule:small-conductance mechanosensitive channel;
PDBTitle: the open structure of mscs
2d2vv5a2



99.8 20 Fold:Ferredoxin-like
Superfamily:Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family:Mechanosensitive channel protein MscS (YggB), C-terminal domain
3d2vv5a1



99.6 33 Fold:Sm-like fold
Superfamily:Sm-like ribonucleoproteins
Family:Mechanosensitive channel protein MscS (YggB), middle domain
4d2vv5a3



99.1 18 Fold:Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily:Mechanosensitive channel protein MscS (YggB), transmembrane region
Family:Mechanosensitive channel protein MscS (YggB), transmembrane region
5c1ciiA_



99.0 14 PDB header:transmembrane protein
Chain: A: PDB Molecule:colicin ia;
PDBTitle: colicin ia
6c1c1gA_



98.3 12 PDB header:contractile protein
Chain: A: PDB Molecule:tropomyosin;
PDBTitle: crystal structure of tropomyosin at 7 angstroms resolution2 in the spermine-induced crystal form
7c1sjjB_



98.1 11 PDB header:contractile protein
Chain: B: PDB Molecule:actinin;
PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin
8c1bf5A_



97.9 13 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
9c1yvlB_



97.8 6 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
10c3ojaB_



97.6 8 PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex
11c1bg1A_



97.5 10 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
12c2efrB_



97.4 8 PDB header:contractile protein
Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain;
PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution
13c3dtpA_



97.4 12 PDB header:contractile protein
Chain: A: PDB Molecule:myosin 2 heavy chain chimera of smooth and
PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map
14c2oevA_



97.3 13 PDB header:protein transport
Chain: A: PDB Molecule:programmed cell death 6-interacting protein;
PDBTitle: crystal structure of alix/aip1
15c1ei3C_



97.3 8 PDB header:
PDB COMPND:
16c3ghgK_



97.3 9 PDB header:blood clotting
Chain: K: PDB Molecule:fibrinogen beta chain;
PDBTitle: crystal structure of human fibrinogen
17c2d3eD_



97.2 13 PDB header:contractile protein
Chain: D: PDB Molecule:general control protein gcn4 and tropomyosin 1
PDBTitle: crystal structure of the c-terminal fragment of rabbit2 skeletal alpha-tropomyosin
18c3cwgA_



97.2 13 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
19c1ei3E_



97.1 10 PDB header:
PDB COMPND:
20c2fxmB_



96.9 13 PDB header:contractile protein
Chain: B: PDB Molecule:myosin heavy chain, cardiac muscle beta isoform;
PDBTitle: structure of the human beta-myosin s2 fragment
21c1hciB_



not modelled 96.9 8 PDB header:triple-helix coiled coil
Chain: B: PDB Molecule:alpha-actinin 2;
PDBTitle: crystal structure of the rod domain of alpha-actinin
22c3na7A_



not modelled 96.8 10 PDB header:gene regulation, chaperone
Chain: A: PDB Molecule:hp0958;
PDBTitle: 2.2 angstrom structure of the hp0958 protein from helicobacter pylori2 ccug 17874
23c1f5nA_



not modelled 96.7 11 PDB header:signaling protein
Chain: A: PDB Molecule:interferon-induced guanylate-binding protein 1;
PDBTitle: human guanylate binding protein-1 in complex with the gtp2 analogue, gmppnp.
24c3hizB_



not modelled 96.7 9 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
25c3ojaA_



not modelled 96.6 11 PDB header:protein binding
Chain: A: PDB Molecule:leucine-rich immune molecule 1;
PDBTitle: crystal structure of lrim1/apl1c complex
26c1jchC_



not modelled 96.5 11 PDB header:ribosome inhibitor, hydrolase
Chain: C: PDB Molecule:colicin e3;
PDBTitle: crystal structure of colicin e3 in complex with its immunity protein
27c2oexB_



not modelled 96.5 9 PDB header:protein transport
Chain: B: PDB Molecule:programmed cell death 6-interacting protein;
PDBTitle: structure of alix/aip1 v domain
28c3u59C_



not modelled 96.4 15 PDB header:contractile protein
Chain: C: PDB Molecule:tropomyosin beta chain;
PDBTitle: n-terminal 98-aa fragment of smooth muscle tropomyosin beta
29c1deqO_



not modelled 96.4 9 PDB header:
PDB COMPND:
30c1y4cA_



not modelled 96.3 10 PDB header:de novo protein
Chain: A: PDB Molecule:maltose binding protein fused with designed
PDBTitle: designed helical protein fusion mbp
31c3r6nA_



not modelled 96.1 11 PDB header:cell adhesion
Chain: A: PDB Molecule:desmoplakin;
PDBTitle: crystal structure of a rigid four spectrin repeat fragment of the2 human desmoplakin plakin domain
32c1deqF_



not modelled 96.1 7 PDB header:
PDB COMPND:
33c3o0zD_



not modelled 96.0 8 PDB header:transferase
Chain: D: PDB Molecule:rho-associated protein kinase 1;
PDBTitle: crystal structure of a coiled-coil domain from human rock i
34c1g8xB_



not modelled 95.9 8 PDB header:structural protein
Chain: B: PDB Molecule:myosin ii heavy chain fused to alpha-actinin 3;
PDBTitle: structure of a genetically engineered molecular motor
35c2y3aB_



not modelled 95.7 9 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
36c2b9cA_



not modelled 95.4 8 PDB header:contractile protein
Chain: A: PDB Molecule:striated-muscle alpha tropomyosin;
PDBTitle: structure of tropomyosin's mid-region: bending and binding2 sites for actin
37c3l9oA_



not modelled 94.7 12 PDB header:hydrolase
Chain: A: PDB Molecule:atp-dependent rna helicase dob1;
PDBTitle: crystal structure of mtr4, a co-factor of the nuclear exosome
38c3ol1A_



not modelled 94.7 18 PDB header:structural protein
Chain: A: PDB Molecule:vimentin;
PDBTitle: crystal structure of vimentin (fragment 144-251) from homo sapiens,2 northeast structural genomics consortium target hr4796b
39c2gl2B_



not modelled 93.9 11 PDB header:cell adhesion
Chain: B: PDB Molecule:adhesion a;
PDBTitle: crystal structure of the tetra muntant (t66g,r67g,f68g,2 y69g) of bacterial adhesin fada
40c4a55B_



not modelled 93.7 9 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: crystal structure of p110alpha in complex with ish2 of p85alpha and2 the inhibitor pik-108
41c3ipkA_



not modelled 92.9 18 PDB header:cell adhesion
Chain: A: PDB Molecule:agi/ii;
PDBTitle: crystal structure of a3vp1 of agi/ii of streptococcus mutans
42c2ch7A_



not modelled 92.5 12 PDB header:chemotaxis
Chain: A: PDB Molecule:methyl-accepting chemotaxis protein;
PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima
43c2v1yB_



not modelled 92.5 11 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: structure of a phosphoinositide 3-kinase alpha adaptor-2 binding domain (abd) in a complex with the ish2 domain3 from p85 alpha
44c2zv4O_



not modelled 91.6 12 PDB header:structural protein
Chain: O: PDB Molecule:major vault protein;
PDBTitle: the structure of rat liver vault at 3.5 angstrom resolution
45c2v71A_



not modelled 90.4 15 PDB header:nuclear protein
Chain: A: PDB Molecule:nuclear distribution protein nude-like 1;
PDBTitle: coiled-coil region of nudel
46c3hnwB_



not modelled 90.2 10 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a basic coiled-coil protein of unknown function2 from eubacterium eligens atcc 27750
47c2rd0B_



not modelled 89.4 6 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: structure of a human p110alpha/p85alpha complex
48c2v66C_



not modelled 88.7 9 PDB header:structural protein
Chain: C: PDB Molecule:nuclear distribution protein nude-like 1;
PDBTitle: crystal structure of the coiled-coil domain of ndel1 (a.a.2 58 to 169)c
49c1l8dB_



not modelled 88.3 9 PDB header:replication
Chain: B: PDB Molecule:dna double-strand break repair rad50 atpase;
PDBTitle: rad50 coiled-coil zn hook
50c2wpqA_



not modelled 87.8 9 PDB header:membrane protein
Chain: A: PDB Molecule:trimeric autotransporter adhesin fragment;
PDBTitle: salmonella enterica sada 479-519 fused to gcn4 adaptors (2 sadak3, in-register fusion)
51c2zkrt_



not modelled 86.7 21 PDB header:ribosomal protein/rna
Chain: T: PDB Molecule:rna expansion segment es39 part iii;
PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map
52c2e7sM_



not modelled 86.1 14 PDB header:endocytosis/exocytosis
Chain: M: PDB Molecule:rab guanine nucleotide exchange factor sec2;
PDBTitle: crystal structure of the yeast sec2p gef domain
53c2i1jA_



not modelled 85.0 12 PDB header:cell adhesion, membrane protein
Chain: A: PDB Molecule:moesin;
PDBTitle: moesin from spodoptera frugiperda at 2.1 angstroms resolution
54c1deqD_



not modelled 84.5 12 PDB header:
PDB COMPND:
55c2dq3A_



not modelled 84.3 13 PDB header:ligase
Chain: A: PDB Molecule:seryl-trna synthetase;
PDBTitle: crystal structure of aq_298
56c2j69D_



not modelled 81.6 9 PDB header:hydrolase
Chain: D: PDB Molecule:bacterial dynamin-like protein;
PDBTitle: bacterial dynamin-like protein bdlp
57d2hqha1



not modelled 81.5 38 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
58c2qihA_



not modelled 81.3 5 PDB header:cell adhesion
Chain: A: PDB Molecule:protein uspa1;
PDBTitle: crystal structure of 527-665 fragment of uspa1 protein from2 moraxella catarrhalis
59d2cqaa1



not modelled 79.5 36 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:TIP49 domain
60d1nz9a_



not modelled 79.3 27 Fold:SH3-like barrel
Superfamily:Translation proteins SH3-like domain
Family:N-utilization substance G protein NusG, C-terminal domain
61c1i84V_



not modelled 79.0 11 PDB header:contractile protein
Chain: V: PDB Molecule:smooth muscle myosin heavy chain;
PDBTitle: cryo-em structure of the heavy meromyosin subfragment of2 chicken gizzard smooth muscle myosin with regulatory light3 chain in the dephosphorylated state. only c alphas4 provided for regulatory light chain. only backbone atoms5 provided for s2 fragment.
62c3u1aC_



not modelled 78.8 12 PDB header:contractile protein
Chain: C: PDB Molecule:smooth muscle tropomyosin alpha;
PDBTitle: n-terminal 81-aa fragment of smooth muscle tropomyosin alpha
63c2xgjA_



not modelled 77.8 10 PDB header:hydrolase/rna
Chain: A: PDB Molecule:atp-dependent rna helicase dob1;
PDBTitle: structure of mtr4, a dexh helicase involved in nuclear rna2 processing and surveillance
64d1nppa2



not modelled 77.2 24 Fold:SH3-like barrel
Superfamily:Translation proteins SH3-like domain
Family:N-utilization substance G protein NusG, C-terminal domain
65c2jvvA_



not modelled 76.5 15 PDB header:transcription
Chain: A: PDB Molecule:transcription antitermination protein nusg;
PDBTitle: solution structure of e. coli nusg carboxyterminal domain
66c2kvqG_



not modelled 76.5 15 PDB header:transcription
Chain: G: PDB Molecule:transcription antitermination protein nusg;
PDBTitle: solution structure of nuse:nusg-ctd complex
67c2e6zA_



not modelled 71.6 18 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt5;
PDBTitle: solution structure of the second kow motif of human2 transcription elongation factor spt5
68c2dfsA_



not modelled 71.6 11 PDB header:contractile protein/transport protein
Chain: A: PDB Molecule:myosin-5a;
PDBTitle: 3-d structure of myosin-v inhibited state
69d1vqoq1



not modelled 71.4 24 Fold:SH3-like barrel
Superfamily:Translation proteins SH3-like domain
Family:Ribosomal proteins L24p and L21e
70c2p22C_



not modelled 69.3 10 PDB header:transport protein
Chain: C: PDB Molecule:protein srn2;
PDBTitle: structure of the yeast escrt-i heterotetramer core
71d2cp6a1



not modelled 69.0 39 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
72c2v4hA_



not modelled 68.1 12 PDB header:transcription
Chain: A: PDB Molecule:nf-kappa-b essential modulator;
PDBTitle: nemo cc2-lz domain - 1d5 darpin complex
73d2plsa1



not modelled 66.9 24 Fold:FAD-binding/transporter-associated domain-like
Superfamily:FAD-binding/transporter-associated domain-like
Family:CorC/HlyC domain-like
74c2vfyA_



not modelled 66.8 10 PDB header:hydrolase
Chain: A: PDB Molecule:akap18 delta;
PDBTitle: akap18 delta central domain
75d2ap3a1



not modelled 66.6 14 Fold:Four-helical up-and-down bundle
Superfamily:MW0975(SA0943)-like
Family:MW0975(SA0943)-like
76c1quuA_



not modelled 66.1 10 PDB header:contractile protein
Chain: A: PDB Molecule:human skeletal muscle alpha-actinin 2;
PDBTitle: crystal structure of two central spectrin-like repeats from2 alpha-actinin
77d1t9ha1



not modelled 64.6 29 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:Cold shock DNA-binding domain-like
78c3g67A_



not modelled 63.8 9 PDB header:signaling protein
Chain: A: PDB Molecule:methyl-accepting chemotaxis protein;
PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima
79c3qo8A_



not modelled 63.8 17 PDB header:ligase
Chain: A: PDB Molecule:seryl-trna synthetase, cytoplasmic;
PDBTitle: crystal structure of seryl-trna synthetase from candida albicans
80d1whka_



not modelled 62.3 26 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
81c4a1cS_



not modelled 60.3 40 PDB header:ribosome
Chain: S: PDB Molecule:rpl26;
PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 4.
82c2jeeA_



not modelled 60.3 15 PDB header:cell cycle
Chain: A: PDB Molecule:yiiu;
PDBTitle: xray structure of e. coli yiiu
83d1whma_



not modelled 59.9 32 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
84d1yeza1



not modelled 59.9 21 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:TRAM domain
85d1vqot1



not modelled 59.5 32 Fold:SH3-like barrel
Superfamily:Translation proteins SH3-like domain
Family:Ribosomal proteins L24p and L21e
86c3iz5Y_



not modelled 57.7 29 PDB header:ribosome
Chain: Y: PDB Molecule:60s ribosomal protein l26 (l24p);
PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome
87d2coya1



not modelled 57.5 36 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
88c2rcnA_



not modelled 57.3 31 PDB header:hydrolase
Chain: A: PDB Molecule:probable gtpase engc;
PDBTitle: crystal structure of the ribosomal interacting gtpase yjeq from the2 enterobacterial species salmonella typhimurium.
89c2k52A_



not modelled 57.1 18 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein mj1198;
PDBTitle: structure of uncharacterized protein mj1198 from2 methanocaldococcus jannaschii. northeast structural3 genomics target mjr117b
90d2gvha1



not modelled 57.0 36 Fold:Thioesterase/thiol ester dehydrase-isomerase
Superfamily:Thioesterase/thiol ester dehydrase-isomerase
Family:4HBT-like
91c2no2A_



not modelled 56.3 11 PDB header:cell adhesion
Chain: A: PDB Molecule:huntingtin-interacting protein 1;
PDBTitle: crystal structure of the dllrkn-containing coiled-coil2 domain of huntingtin-interacting protein 1
92d2cp2a1



not modelled 56.0 25 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
93c2eqbC_



not modelled 55.8 8 PDB header:endocytosis/exocytosis
Chain: C: PDB Molecule:rab guanine nucleotide exchange factor sec2;
PDBTitle: crystal structure of the rab gtpase sec4p, the sec2p gef2 domain, and phosphate complex
94c3a7pB_



not modelled 55.4 12 PDB header:protein transport
Chain: B: PDB Molecule:autophagy protein 16;
PDBTitle: the crystal structure of saccharomyces cerevisiae atg16
95c3n4xB_



not modelled 55.2 10 PDB header:replication
Chain: B: PDB Molecule:monopolin complex subunit csm1;
PDBTitle: structure of csm1 full-length
96d2cp5a1



not modelled 55.0 20 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
97d1y7ua1



not modelled 55.0 25 Fold:Thioesterase/thiol ester dehydrase-isomerase
Superfamily:Thioesterase/thiol ester dehydrase-isomerase
Family:4HBT-like
98c3iz5U_



not modelled 55.0 24 PDB header:ribosome
Chain: U: PDB Molecule:60s ribosomal protein l21 (l21e);
PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome
99c1q46A_



not modelled 54.7 19 PDB header:translation
Chain: A: PDB Molecule:translation initiation factor 2 alpha subunit;
PDBTitle: crystal structure of the eif2 alpha subunit from2 saccharomyces cerevisia
100d2coza1



not modelled 54.6 32 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
101c2zvnF_



not modelled 54.3 12 PDB header:signaling protein/transcription
Chain: F: PDB Molecule:nf-kappa-b essential modulator;
PDBTitle: nemo cozi domain incomplex with diubiquitin in p2121212 space group
102d1whja_



not modelled 53.2 33 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
103c4a1aP_



not modelled 53.2 21 PDB header:ribosome
Chain: P: PDB Molecule:60s ribosomal protein l21;
PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 3.
104d2p13a1



not modelled 53.1 10 Fold:FAD-binding/transporter-associated domain-like
Superfamily:FAD-binding/transporter-associated domain-like
Family:CorC/HlyC domain-like
105c3b7kA_



not modelled 52.8 21 PDB header:hydrolase
Chain: A: PDB Molecule:acyl-coenzyme a thioesterase 12;
PDBTitle: human acyl-coenzyme a thioesterase 12
106c2gvhC_



not modelled 52.6 25 PDB header:hydrolase
Chain: C: PDB Molecule:agr_l_2016p;
PDBTitle: crystal structure of acyl-coa hydrolase (15159470) from agrobacterium2 tumefaciens at 2.65 a resolution
107c3izcU_



not modelled 51.8 24 PDB header:ribosome
Chain: U: PDB Molecule:60s ribosomal protein rpl21 (l21e);
PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome
108d2e3ha1



not modelled 51.2 35 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
109c1mhsA_



51.2 9 PDB header:membrane protein, proton transport
Chain: A: PDB Molecule:plasma membrane atpase;
PDBTitle: model of neurospora crassa proton atpase
110c2zkrq_



not modelled 50.8 27 PDB header:ribosomal protein/rna
Chain: Q: PDB Molecule:rna expansion segment es31 part ii;
PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map
111d2e3ia1



not modelled 50.7 20 Fold:SH3-like barrel
Superfamily:Cap-Gly domain
Family:Cap-Gly domain
112d1h6za2



not modelled 50.5 38 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
113d1vpma_



not modelled 50.3 18 Fold:Thioesterase/thiol ester dehydrase-isomerase
Superfamily:Thioesterase/thiol ester dehydrase-isomerase
Family:4HBT-like
114c3m9bK_



not modelled 49.4 22 PDB header:chaperone
Chain: K: PDB Molecule:proteasome-associated atpase;
PDBTitle: crystal structure of the amino terminal coiled coil domain and the2 inter domain of the mycobacterium tuberculosis proteasomal atpase mpa
115c2yv5A_



not modelled 49.0 15 PDB header:hydrolase
Chain: A: PDB Molecule:yjeq protein;
PDBTitle: crystal structure of yjeq from aquifex aeolicus
116d1yvca1



not modelled 49.0 25 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:TRAM domain
117d2o1ra1



not modelled 48.8 18 Fold:FAD-binding/transporter-associated domain-like
Superfamily:FAD-binding/transporter-associated domain-like
Family:CorC/HlyC domain-like
118c3qh9A_



not modelled 48.8 11 PDB header:structural protein
Chain: A: PDB Molecule:liprin-beta-2;
PDBTitle: human liprin-beta2 coiled-coil
119d1ylia1



not modelled 48.8 29 Fold:Thioesterase/thiol ester dehydrase-isomerase
Superfamily:Thioesterase/thiol ester dehydrase-isomerase
Family:4HBT-like
120c2z0wA_



not modelled 48.4 25 PDB header:protein binding
Chain: A: PDB Molecule:cap-gly domain-containing linker protein 4;
PDBTitle: crystal structure of the 2nd cap-gly domain in human restin-2 like protein 2 reveals a swapped-dimer

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0