Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	L	S	L	W	Q	Q	C	L	A	R	L	Q	D	E	L	P	A	T	E	F	S	M	W	I	R	P	L	Q	A	E	L	S	D	N	T	L	A	L	Y	A	P	N	R	F	V	L	D	W	V	R	D	K	Y	L	N	N	I	N
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	L	T	S	F	C	G	A	D	A	P	Q	L	R	F	E	V	G	T	K	P	V	T	Q	T	P	Q	A	A	V	T	S	N	V	A	A	P	A	Q	V	A	Q	T	Q	P	Q	R	A	A	P	S	T	R	S	G	W	D	N	V
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	A	P	A	E	P	T	Y	R	S	N	V	N	V	K	H	T	F	D	N	F	V	E	G	K	S	N	Q	L	A	R	A	A	A	R	Q	V	A	D	N	P	G	G	A	Y	N	P	L	F	L	Y	G	G	T	G	L	G	K	T	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	L	H	A	V	G	N	G	I	M	A	R	K	P	N	A	K	V	V	Y	M	H	S	E	R	F	V	Q	D	M	V	K	A	L	Q	N	N	A	I	E	E	F	K	R	Y	Y	R	S	V	D	A	L	L	I	D	D	I	Q	F	F
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	N	K	E	R	S	Q	E	E	F	F	H	T	F	N	A	L	L	E	G	N	Q	Q	I	I	L	T	S	D	R	Y	P	K	E	I	N	G	V	E	D	R	L	K	S	R	F	G	W	G	L	T	V	A	I	E	P	P	E	L	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	R	V	A	I	L	M	K	K	A	D	E	N	D	I	R	L	P	G	E	V	A	F	F	I	A	K	R	L	R	S	N	V	R	E	L	E	G	A	L	N	R	V	I	A	N	A	N	F	T	G	R	A	I	T	I	D	F	V	R
Secondary structure
SS confidence
Disorder														?	?		?																																	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	A	L	R	D	L	L	A	L	Q	E	K	L	V	T	I	D	N	I	Q	K	T	V	A	E	Y	Y	K	I	K	V	A	D	L	L	S	K	R	R	S	R	S	V	A	R	P	R	Q	M	A	M	A	L	A	K	E	L	T	N	H
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?																					?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.
Sequence		S	L	P	E	I	G	D	A	F	G	G	R	D	H	T	T	V	L	H	A	C	R	K	I	E	Q	L	R	E	E	S	H	D	I	K	E	D	F	S	N	L	I	R	T	L	S	S
Secondary structure
SS confidence
Disorder																															?	?															?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2hcb chain C Region: 132 - 465 Aligned: 310 Modelled: 320 Confidence: 100.0% Identity: 40% PDB header:replication Chain: C: PDB Molecule:chromosomal replication initiator protein dnaa; PDBTitle: structure of amppcp-bound dnaa from aquifex aeolicus Phyre2 PDB 2z4r chain B Region: 130 - 369 Aligned: 239 Modelled: 240 Confidence: 100.0% Identity: 41% PDB header:dna binding protein Chain: B: PDB Molecule:chromosomal replication initiator protein dnaa; PDBTitle: crystal structure of domain iii from the thermotoga2 maritima replication initiation protein dnaa Phyre2 PDB 1l8q chain A domain 2 Region: 130 - 345 Aligned: 212 Modelled: 216 Confidence: 100.0% Identity: 43% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Extended AAA-ATPase domain Phyre2 PDB 3bos chain A Region: 127 - 364 Aligned: 223 Modelled: 235 Confidence: 100.0% Identity: 25% PDB header:hydrolase regulator,dna binding protein Chain: A: PDB Molecule:putative dna replication factor; PDBTitle: crystal structure of a putative dna replication regulator hda2 (sama_1916) from shewanella amazonensis sb2b at 1.75 a resolution Phyre2 PDB 1j1v chain A Region: 374 - 467 Aligned: 94 Modelled: 94 Confidence: 100.0% Identity: 98% Fold: DNA/RNA-binding 3-helical bundle Superfamily: TrpR-like Family: Chromosomal replication initiation factor DnaA C-terminal domain IV Phyre2 PDB 1l8q chain A domain 1 Region: 368 - 465 Aligned: 96 Modelled: 98 Confidence: 99.9% Identity: 33% Fold: DNA/RNA-binding 3-helical bundle Superfamily: TrpR-like Family: Chromosomal replication initiation factor DnaA C-terminal domain IV Phyre2 PDB 3pfi chain B Region: 137 - 416 Aligned: 258 Modelled: 280 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:holliday junction atp-dependent dna helicase ruvb; PDBTitle: 2.7 angstrom resolution crystal structure of a probable holliday2 junction dna helicase (ruvb) from campylobacter jejuni subsp. jejuni3 nctc 11168 in complex with adenosine-5'-diphosphate Phyre2 PDB 3pvp chain A Region: 374 - 466 Aligned: 92 Modelled: 93 Confidence: 99.9% Identity: 39% PDB header:dna binding protein/dna Chain: A: PDB Molecule:chromosomal replication initiator protein dnaa; PDBTitle: structure of mycobacterium tuberculosis dnaa-dbd in complex with box22 dna Phyre2 PDB 1in8 chain A Region: 137 - 448 Aligned: 265 Modelled: 277 Confidence: 99.9% Identity: 23% PDB header:dna binding protein Chain: A: PDB Molecule:holliday junction dna helicase ruvb; PDBTitle: thermotoga maritima ruvb t158v Phyre2 PDB 3hu2 chain C Region: 134 - 370 Aligned: 228 Modelled: 231 Confidence: 99.9% Identity: 17% PDB header:transport protein Chain: C: PDB Molecule:transitional endoplasmic reticulum atpase; PDBTitle: structure of p97 n-d1 r86a mutant in complex with atpgs Phyre2 PDB 2kjq chain A Region: 134 - 296 Aligned: 138 Modelled: 149 Confidence: 99.9% Identity: 19% PDB header:replication Chain: A: PDB Molecule:dnaa-related protein; PDBTitle: solution structure of protein nmb1076 from neisseria meningitidis.2 northeast structural genomics consortium target mr101b. Phyre2 PDB 3cf1 chain C Region: 134 - 381 Aligned: 235 Modelled: 243 Confidence: 99.9% Identity: 18% PDB header:transport protein Chain: C: PDB Molecule:transitional endoplasmic reticulum atpase; PDBTitle: structure of p97/vcp in complex with adp/adp.alfx Phyre2 PDB 1in4 chain A domain 2 Region: 132 - 366 Aligned: 216 Modelled: 228 Confidence: 99.9% Identity: 21% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Extended AAA-ATPase domain Phyre2 PDB 3b9p chain A Region: 133 - 381 Aligned: 235 Modelled: 244 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:cg5977-pa, isoform a; PDBTitle: spastin Phyre2 PDB 2ce7 chain B Region: 133 - 385 Aligned: 244 Modelled: 253 Confidence: 99.9% Identity: 20% PDB header:cell division protein Chain: B: PDB Molecule:cell division protein ftsh; PDBTitle: edta treated Phyre2 PDB 2dhr chain C Region: 133 - 375 Aligned: 234 Modelled: 243 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:ftsh; PDBTitle: whole cytosolic region of atp-dependent metalloprotease2 ftsh (g399l) Phyre2 PDB 2ce7 chain A domain 2 Region: 133 - 367 Aligned: 226 Modelled: 230 Confidence: 99.9% Identity: 20% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Extended AAA-ATPase domain Phyre2 PDB 2zam chain A Region: 133 - 388 Aligned: 238 Modelled: 251 Confidence: 99.9% Identity: 16% PDB header:protein transport Chain: A: PDB Molecule:vacuolar protein sorting-associating protein 4b; PDBTitle: crystal structure of mouse skd1/vps4b apo-form Phyre2 PDB 1xwi chain A Region: 134 - 388 Aligned: 242 Modelled: 255 Confidence: 99.9% Identity: 16% PDB header:protein transport Chain: A: PDB Molecule:skd1 protein; PDBTitle: crystal structure of vps4b Phyre2 PDB 1iy2 chain A Region: 133 - 363 Aligned: 222 Modelled: 226 Confidence: 99.9% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent metalloprotease ftsh; PDBTitle: crystal structure of the ftsh atpase domain from thermus2 thermophilus Phyre2 PDB 2e0g chain A Region: 2 - 108 Aligned: 107 Modelled: 107 Confidence: 99.5% Identity: 100% PDB header:replication Chain: A: PDB Molecule:chromosomal replication initiator protein dnaa; PDBTitle: dnaa n-terminal domain Phyre2 1 c2hcbC_ 2 c2z4rB_ 3 d1l8qa2 4 c3bosA_ 5 d1j1va_ 6 d1l8qa1 7 c3pfiB_ 8 c3pvpA_ 9 c1in8A_ 10 c3hu2C_ 11 c2kjqA_ 12 c3cf1C_ 13 d1in4a2 14 c3b9pA_ 15 c2ce7B_ 16 c2dhrC_ 17 d2ce7a2 18 c2zamA_ 19 c1xwiA_ 20 c1iy2A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 c2e0gA_ 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499