Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ64143
DateWed Jul 10 14:20:57 BST 2013
Unique Job ID187dab3a14089fad
SequenceMYNTVWSMDR ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:70.209 Y:42.184 Z:55.033
Model (left) based on template c2oq1A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
Confidence and coverage
Confidence:100.0% Coverage: 53%
246 residues ( 53% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
306 residues ( 66%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTPAVTNGMKDSFISL
Secondary structure 
SS confidence 
Disorder  ??????
??
??????????????????????????????????????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
Secondary structure 
SS confidence 
Disorder 
??
??
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  KYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSRFQQDQLVKEDNIDAVGKN
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  LQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDY
Secondary structure 
SS confidence 
Disorder 
?
?
??
?
?
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKP
Secondary structure 
SS confidence 
Disorder 
????????
?
???
???
?????????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  DLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKNEDSDESYFINEEDENLPHYDEKTWFV
Secondary structure 
SS confidence 
Disorder  ??
??
??????
??????????
?
?
?
????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
Secondary structure 
SS confidence 
Disorder 
?
??
?
Disorder confidence 
 
   .........430.........440.........450.........460.
Sequence  LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPTLCR
Secondary structure 
SS confidence 
Disorder 
?????
???????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 30%)
Alpha helix ( 35%)
Beta strand ( 14%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2oq1 chain A

3D model

Region: 59 - 452
Aligned: 246
Modelled: 265
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2shp chain A

3D model

Region: 61 - 453
Aligned: 202
Modelled: 205
Confidence: 100.0%
Identity: 31%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2b3o chain A

3D model

Region: 64 - 453
Aligned: 200
Modelled: 203
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 3ps5 chain A

3D model

Region: 65 - 453
Aligned: 199
Modelled: 202
Confidence: 100.0%
Identity: 28%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 4fl2 chain A

3D model

Region: 59 - 453
Aligned: 247
Modelled: 265
Confidence: 100.0%
Identity: 32%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 1a81 chain E

3D model

Region: 59 - 452
Aligned: 212
Modelled: 218
Confidence: 100.0%
Identity: 33%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 2ozo chain A

3D model

Region: 58 - 452
Aligned: 247
Modelled: 258
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 3gqi chain B

3D model

Region: 62 - 455
Aligned: 197
Modelled: 204
Confidence: 100.0%
Identity: 32%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 2y3a chain B

3D model

Region: 184 - 455
Aligned: 233
Modelled: 239
Confidence: 100.0%
Identity: 74%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 3hiz chain B

3D model

Region: 59 - 311
Aligned: 234
Modelled: 238
Confidence: 100.0%
Identity: 82%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 1pic chain A

3D model

Region: 347 - 458
Aligned: 112
Modelled: 112
Confidence: 99.9%
Identity: 76%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1qad chain A

3D model

Region: 348 - 454
Aligned: 104
Modelled: 107
Confidence: 99.9%
Identity: 82%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 351 - 457
Aligned: 102
Modelled: 107
Confidence: 99.9%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2crh chain A

3D model

Region: 331 - 459
Aligned: 128
Modelled: 129
Confidence: 99.9%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 2eo6 chain A

3D model

Region: 351 - 458
Aligned: 108
Modelled: 108
Confidence: 99.9%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2oq1 chain A domain 2

3D model

Region: 351 - 452
Aligned: 97
Modelled: 102
Confidence: 99.9%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2dlz chain A

3D model

Region: 344 - 458
Aligned: 112
Modelled: 115
Confidence: 99.9%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 1a81 chain A domain 1

3D model

Region: 352 - 459
Aligned: 103
Modelled: 108
Confidence: 99.9%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2abl chain A

3D model

Region: 345 - 452
Aligned: 103
Modelled: 108
Confidence: 99.9%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 1a81 chain E domain 2

3D model

Region: 353 - 452
Aligned: 95
Modelled: 100
Confidence: 99.9%
Identity: 31%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1xa6 chain A domain 2

3D model

Region: 19 - 165
Aligned: 133
Modelled: 133
Confidence: 99.8%
Identity: 24%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2
1
c2oq1A_
2
c2shpA_
3
c2b3oA_
4
c3ps5A_
5
c4fl2A_
6
c1a81E_
7
c2ozoA_
8
c3gqiB_
9
c2y3aB_
10
c3hizB_
11
d1pica_
12
d1qada_
13
d2oq1a1
14
c2crhA_
15
c2eo6A_
16
d2oq1a2
17
c2dlzA_
18
d1a81a1
19
c2ablA_
20
d1a81e2
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
d1xa6a2
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2oq1A_
100.0 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
2c2shpA_
100.0 31 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
3c2b3oA_
100.0 34 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
4c3ps5A_
100.0 28 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
5c4fl2A_
100.0 32 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
6c1a81E_
100.0 33 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
7c2ozoA_
100.0 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
8c3gqiB_
100.0 32 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
9c2y3aB_
100.0 74 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
10c3hizB_
100.0 82 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
11d1pica_
99.9 76 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
12d1qada_
99.9 82 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
13d2oq1a1
99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
14c2crhA_
99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
15c2eo6A_
99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
16d2oq1a2
99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
17c2dlzA_
99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
18d1a81a1
99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
19c2ablA_
99.9 29 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
20d1a81e2
99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
21d1a81a2
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
22d2shpa2
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
23c2fo0A_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
24c3or8A_
not modelled 99.9 26 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
25c2lctA_
not modelled 99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
26c2dlyA_
not modelled 99.9 37 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
27d1a81e1
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
28d1lkka_
not modelled 99.9 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29c2c9wA_
not modelled 99.9 25 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
30c2eobA_
not modelled 99.9 36 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
31c2lqnA_
not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
32c2ge9A_
not modelled 99.9 35 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
33d1csya_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34d1opka2
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35c1oplA_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
36d1k9aa2
not modelled 99.9 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d2izva2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d1nrva_
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39d1jwoa_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40d1qcfa2
not modelled 99.9 39 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41d1luia_
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d1ayaa_
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43d1o48a_
not modelled 99.9 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44d1rjaa_
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c2eo3A_
not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
46d1blja_
not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47c2vifA_
not modelled 99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
48c3nhnA_
not modelled 99.9 37 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
49d3c7ia1
not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d2qmsa1
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51c2gsbA_
not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
52c1x27F_
not modelled 99.9 36 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
53d1fhsa_
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54c2augB_
not modelled 99.9 27 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
55c1ka6A_
not modelled 99.9 29 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
56c2knoA_
not modelled 99.9 32 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
57c1k9aB_
not modelled 99.9 34 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
58c2xp1A_
not modelled 99.9 15 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
59c2hdxB_
not modelled 99.9 24 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
60d1f2fa_
not modelled 99.9 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61d1g83a2
not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62c1y57A_
not modelled 99.8 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
63c2ysxA_
not modelled 99.8 29 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
64d1bkla_
not modelled 99.8 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65c2ci8A_
not modelled 99.8 27 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
66c1x6cA_
not modelled 99.8 29 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
67c2ekxA_
not modelled 99.8 33 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
68c2izvA_
not modelled 99.8 23 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
69c2hmhA_
not modelled 99.8 21 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
70d1i3za_
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d1d4ta_
not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72d2cs0a1
not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
73d2eyva1
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74d2shpa3
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75d1r1qa_
not modelled 99.8 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1fu6a_
not modelled 99.8 84 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d1mila_
not modelled 99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c2h8hA_
not modelled 99.8 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
79c1g83A_
not modelled 99.8 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
80d1jyra_
not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2dm0A_
not modelled 99.8 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
82c2c0iA_
not modelled 99.8 33 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
83d1cwea_
not modelled 99.8 43 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d2fcia1
not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85c2dcrA_
not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
86c3mazA_
not modelled 99.8 17 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
87d2c9wa2
not modelled 99.8 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88c2el8A_
not modelled 99.8 20 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
89c2kk6A_
not modelled 99.8 35 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
90d1xa6a2
99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91d1rpya_
not modelled 99.7 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
92c2eyzA_
not modelled 99.7 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
93c1rqqC_
not modelled 99.7 24 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
94c2cr4A_
not modelled 99.7 26 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
95c3gxxB_
not modelled 99.7 26 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
96c2dvjA_
not modelled 99.7 34 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
97c3qwxX_
not modelled 99.7 25 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
98c3qwyA_
not modelled 99.7 22 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
99c2dx0B_
not modelled 99.7 39 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
100c2eyyA_
not modelled 99.7 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
101c2v1yB_
not modelled 99.5 76 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: structure of a phosphoinositide 3-kinase alpha adaptor-2 binding domain (abd) in a complex with the ish2 domain3 from p85 alpha
102c1xa6A_
not modelled 99.4 26 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
103d1uura3
not modelled 99.4 16 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1bf5a3
not modelled 99.2 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105d1bg1a3
not modelled 98.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106c3cblA_
not modelled 98.8 34 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
107c4a55B_
not modelled 98.6 78 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: crystal structure of p110alpha in complex with ish2 of p85alpha and2 the inhibitor pik-108
108c3ojaB_
not modelled 98.2 8 PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex
109c3na7A_
not modelled 98.1 13 PDB header:gene regulation, chaperone
Chain: A: PDB Molecule:hp0958;
PDBTitle: 2.2 angstrom structure of the hp0958 protein from helicobacter pylori2 ccug 17874
110c2efrB_
not modelled 98.1 16 PDB header:contractile protein
Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain;
PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution
111c3vkgA_
not modelled 98.1 10 PDB header:motor protein
Chain: A: PDB Molecule:dynein heavy chain, cytoplasmic;
PDBTitle: x-ray structure of an mtbd truncation mutant of dynein motor domain
112c1uusA_
not modelled 98.0 18 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
113c2cblA_
not modelled 98.0 16 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
114c3bunB_
not modelled 98.0 16 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
115c1ei3C_
not modelled 97.9 14 PDB header:blood clotting
Chain: C: PDB Molecule:fibrinogen;
PDBTitle: crystal structure of native chicken fibrinogen
116c4gkwB_
not modelled 97.8 12 PDB header:structural protein
Chain: B: PDB Molecule:spindle assembly abnormal protein 6;
PDBTitle: crystal structure of the coiled-coil domain of c. elegans sas-6
117c1bf5A_
not modelled 97.8 7 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
118c3o0zD_
not modelled 97.8 15 PDB header:transferase
Chain: D: PDB Molecule:rho-associated protein kinase 1;
PDBTitle: crystal structure of a coiled-coil domain from human rock i
119c2rd0B_
not modelled 97.6 78 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: structure of a human p110alpha/p85alpha complex
120c3ghgK_
not modelled 97.5 12 PDB header:blood clotting
Chain: K: PDB Molecule:fibrinogen beta chain;
PDBTitle: crystal structure of human fibrinogen

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite