Phyre 2 Results for P22523

Email	l.a.kelley@imperial.ac.uk
Description	P22523
Date	Wed Jan 25 15:20:42 GMT 2012
Unique Job ID	067380b0756e9b95

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3eukC_

Top template information

PDB header:cell cycle
Chain: C: PDB Molecule:chromosome partition protein mukb, linker;
PDBTitle: crystal structure of muke-mukf(residues 292-443)-mukb(head2 domain)-atpgammas complex, asymmetric dimer

Confidence and coverage

Confidence:

100.0%

Coverage:

16%

232 residues ( 16% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1352 residues ( 91%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M I E R G K F R S L T L I N W N G F F A R T F D L D E L V T T L S G G N G A G K S T T M A A F V T A L I P D L T L L H F

Secondary structure

SS confidence

Disorder ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence R N T T E A G A T S G S R D K G L H G K L K A G V C Y S M L D T I N S R H Q R V V V G V R L Q Q V A G R D R K V D I K P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence F A I Q G L P M S V Q P T Q L V T E T L N E R Q A R V L P L N E L K D K L E A M E G V Q F K Q F N S I T D Y H S L M F D

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence L G I I A R R L R S A S D R S K F Y R L I E A S L Y G G I S S A I T R S L R D Y L L P E N S G V R K A F Q D M E A A L R

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E N R M T L E A I R V T Q S D R D L F K H L I S E A T N Y V A A D Y M R H A N E R R V H L D K A L E F R R E L H T S R Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence Q L A A E Q Y K H V D M A R E L A E H N G A E G D L E A D Y Q A A S D H L N L V Q T A L R Q Q E K I E R Y E A D L D E L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Q I R L E E Q N E V V A E A I E R Q Q E N E A R A E A A E L E V D E L K S Q L A D Y Q Q A L D V Q Q T R A I Q Y N Q A I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence A A L N R A K E L C H L P D L T A D C A A E W L E T F Q A K E L E A T E K M L S L E Q K M S M A Q T A H S Q F E Q A Y Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence L V V A I N G P L A R N E A W D V A R E L L R E G V D Q R H L A E Q V Q P L R M R L S E L E Q R L R E Q Q E A E R L L A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence D F C K R Q G K N F D I D E L E A L H Q E L E A R I A S L S D S V S N A R E E R M A L R Q E Q E Q L Q S R I Q S L M Q R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence A P V W L A A Q N S L N Q L S E Q C G E E F T S S Q D V T E Y L Q Q L L E R E R E A I V E R D E V G A R K N A V D E E I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence E R L S Q P G G S E D Q R L N A L A E R F G G V L L S E I Y D D V S L E D A P Y F S A L Y G P S R H A I V V P D L S Q V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence T E H L E G L T D C P E D L Y L I E G D P Q S F D D S V F S V D E L E K A V V V K I A D R Q W R Y S R F P E V P L F G R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence A A R E S R I E S L H A E R E V L S E R F A T L S F D V Q K T Q R L H Q A F S R F I G S H L A V A F E S D P E A E I R Q

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence L N S R R V E L E R A L S N H E N D N Q Q Q R I Q F E Q A K E G V T A L N R I L P R L N L L A D D S L A D R V D E I R E

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence R L D E A Q E A A R F V Q Q F G N Q L A K L E P I V S V L Q S D P E Q F E Q L K E D Y A Y S Q Q M Q R D A R Q Q A F A L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence T E V V Q R R A H F S Y S D S A E M L S G N S D L N E K L R E R L E Q A E A E R T R A R E A L R G H A A Q L S Q Y N Q V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence L A S L K S S Y D T K K E L L N D L Q R E L Q D I G V R A D S G A E E R A R I R R D E L H A Q L S N N R S R R N Q L E K

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence A L T F C E A E M D N L T R K L R K L E R D Y F E M R E Q V V T A K A G W C A V M R M V K D N G V E R R L H R R E L A Y

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence L S A D D L R S M S D K A L G A L R L A V A D N E H L R D V L R M S E D P K R P E R K I Q F F V A V Y Q H L R E R I R Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence D I I R T D D P V E A I E Q M E I E L S R L T E E L T S R E Q K L A I S S R S V A N I I R K T I Q R E Q N R I R M L N Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence G L Q N V S F G Q V N S V R L N V N V R E T H A M L L D V L S E Q H E Q H Q D L F N S N R L T F S E A L A K L Y Q R L N

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence P Q I D M G Q R T P Q T I G E E L L D Y R N Y L E M E V E V N R G S D G W L R A E S G A L S T G E A I G T G M S I L V M

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence V V Q S W E D E S R R L R G K D I S P C R L L F L D E A A R L D A R S I A T L F E L C E R L Q M Q L I I A A P E N I S P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
?
? ? ?
? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . .

Sequence E K G T T Y K L V R K V F Q N T E H V H V V G L R G F A P Q L P E T L P G T D E A P S Q A S

Secondary structure

SS confidence

Disorder ? ? ? ?
?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3euk chain C

Region: 1222 - 1467
Aligned: 232
Modelled: 246
Confidence: 100.0%
Identity: 72%
PDB header:cell cycle
Chain: C: PDB Molecule:chromosome partition protein mukb, linker;
PDBTitle: crystal structure of muke-mukf(residues 292-443)-mukb(head2 domain)-atpgammas complex, asymmetric dimer

Phyre2

PDB 1qhl chain A

Region: 4 - 224
Aligned: 203
Modelled: 203
Confidence: 99.7%
Identity: 99%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: ABC transporter ATPase domain-like

Phyre2

PDB 3qg5 chain A

Region: 5 - 399
Aligned: 340
Modelled: 339
Confidence: 99.6%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:rad50;
PDBTitle: the mre11:rad50 complex forms an atp dependent molecular clamp in dna2 double-strand break repair

Phyre2

PDB 1xex chain A

Region: 7 - 161
Aligned: 155
Modelled: 155
Confidence: 99.5%
Identity: 14%
PDB header:cell cycle
Chain: A: PDB Molecule:smc protein;
PDBTitle: structural biochemistry of atp-driven dimerization and dna2 stimulated activation of smc atpases.

Phyre2

PDB 3qku chain B

Region: 6 - 178
Aligned: 173
Modelled: 173
Confidence: 99.5%
Identity: 11%
PDB header:replication
Chain: B: PDB Molecule:dna double-strand break repair rad50 atpase;
PDBTitle: mre11 rad50 binding domain in complex with rad50 and amp-pnp

Phyre2

PDB 3auy chain B

Region: 6 - 192
Aligned: 183
Modelled: 187
Confidence: 99.5%
Identity: 11%
PDB header:recombination
Chain: B: PDB Molecule:dna double-strand break repair rad50 atpase;
PDBTitle: crystal structure of rad50 bound to adp

Phyre2

PDB 1ii8 chain A

Region: 6 - 194
Aligned: 189
Modelled: 189
Confidence: 99.4%
Identity: 10%
PDB header:replication
Chain: A: PDB Molecule:rad50 abc-atpase;
PDBTitle: crystal structure of the p. furiosus rad50 atpase domain

Phyre2

PDB 1w1w chain A

Region: 5 - 178
Aligned: 152
Modelled: 152
Confidence: 99.4%
Identity: 15%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: ABC transporter ATPase domain-like

Phyre2

PDB 1e69 chain A

Region: 6 - 142
Aligned: 121
Modelled: 122
Confidence: 99.4%
Identity: 17%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: ABC transporter ATPase domain-like

Phyre2

PDB 2o5v chain A

Region: 6 - 103
Aligned: 94
Modelled: 98
Confidence: 99.2%
Identity: 23%
PDB header:replication/recombination
Chain: A: PDB Molecule:dna replication and repair protein recf;
PDBTitle: recombination mediator recf

Phyre2

PDB 1us8 chain A

Region: 6 - 57
Aligned: 52
Modelled: 52
Confidence: 99.2%
Identity: 25%
PDB header:dna repair
Chain: A: PDB Molecule:dna double-strand break repair rad50 atpase;
PDBTitle: the rad50 signature motif: essential to atp binding and2 biological function

Phyre2

PDB 1ii8 chain B

Region: 1280 - 1461
Aligned: 169
Modelled: 182
Confidence: 98.5%
Identity: 17%
PDB header:replication
Chain: B: PDB Molecule:rad50 abc-atpase;
PDBTitle: crystal structure of the p. furiosus rad50 atpase domain

Phyre2

PDB 1xex chain B

Region: 1309 - 1480
Aligned: 155
Modelled: 172
Confidence: 98.4%
Identity: 15%
PDB header:cell cycle
Chain: B: PDB Molecule:smc protein;
PDBTitle: structural biochemistry of atp-driven dimerization and dna2 stimulated activation of smc atpases.

Phyre2

PDB 3ibp chain A

Region: 573 - 853
Aligned: 281
Modelled: 281
Confidence: 98.2%
Identity: 99%
PDB header:cell cycle
Chain: A: PDB Molecule:chromosome partition protein mukb;
PDBTitle: the crystal structure of the dimerization domain of escherichia coli2 structural maintenance of chromosomes protein mukb

Phyre2

PDB 1v43 chain A domain 3

Region: 6 - 48
Aligned: 43
Modelled: 43
Confidence: 97.9%
Identity: 28%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: ABC transporter ATPase domain-like

Phyre2

PDB 1z47 chain B

Region: 9 - 64
Aligned: 56
Modelled: 56
Confidence: 97.9%
Identity: 16%
PDB header:ligand binding protein
Chain: B: PDB Molecule:putative abc-transporter atp-binding protein;
PDBTitle: structure of the atpase subunit cysa of the putative2 sulfate atp-binding cassette (abc) transporter from3 alicyclobacillus acidocaldarius

Phyre2

PDB 1vci chain A

Region: 6 - 64
Aligned: 59
Modelled: 59
Confidence: 97.9%
Identity: 24%
PDB header:transport protein
Chain: A: PDB Molecule:sugar-binding transport atp-binding protein;
PDBTitle: crystal structure of the atp-binding cassette of multisugar2 transporter from pyrococcus horikoshii ot3 complexed with3 atp

Phyre2

PDB 2awn chain A domain 2

Region: 6 - 48
Aligned: 43
Modelled: 43
Confidence: 97.8%
Identity: 21%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: ABC transporter ATPase domain-like

Phyre2

PDB 1g29 chain 1 domain 2

Region: 7 - 48
Aligned: 42
Modelled: 42
Confidence: 97.8%
Identity: 26%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: ABC transporter ATPase domain-like

Phyre2

PDB 2it1 chain B

Region: 10 - 64
Aligned: 55
Modelled: 55
Confidence: 97.8%
Identity: 24%
PDB header:transport protein
Chain: B: PDB Molecule:362aa long hypothetical maltose/maltodextrin
PDBTitle: structure of ph0203 protein from pyrococcus horikoshii

Phyre2

PDB 1c1g chain A

Region: 838 - 1126
Aligned: 283
Modelled: 283
Confidence: 97.2%
Identity: 11%
PDB header:contractile protein
Chain: A: PDB Molecule:tropomyosin;
PDBTitle: crystal structure of tropomyosin at 7 angstroms resolution2 in the spermine-induced crystal form

Phyre2

PDB 1f5n chain A

Region: 28 - 499
Aligned: 448
Modelled: 448
Confidence: 96.3%
Identity: 11%
PDB header:signaling protein
Chain: A: PDB Molecule:interferon-induced guanylate-binding protein 1;
PDBTitle: human guanylate binding protein-1 in complex with the gtp2 analogue, gmppnp.

Phyre2

PDB 3oja chain B

Region: 963 - 1109
Aligned: 146
Modelled: 146
Confidence: 96.3%
Identity: 14%
PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex

Phyre2

PDB 3ghg chain K

Region: 982 - 1096
Aligned: 115
Modelled: 115
Confidence: 96.1%
Identity: 11%
PDB header:blood clotting
Chain: K: PDB Molecule:fibrinogen beta chain;
PDBTitle: crystal structure of human fibrinogen

Phyre2

PDB 1deq chain O

Region: 984 - 1096
Aligned: 113
Modelled: 113
Confidence: 96.0%
Identity: 12%
PDB header:
PDB COMPND:

Phyre2

PDB 1cii chain A

Region: 832 - 1386
Aligned: 503
Modelled: 503
Confidence: 95.9%
Identity: 14%
PDB header:transmembrane protein
Chain: A: PDB Molecule:colicin ia;
PDBTitle: colicin ia

Phyre2

100

101

102

103

104

105

106

c1deqO_

107

108

109

c1ciiA_

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210

211

212

213

214

215

216

217

218

219

220

221

222

223

224

225

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240

241

242

243

244

245

246

247

248

249

250

251

252

253

254

255

256

257

258

259

260

261

262

263

264

265

266

267

268

269

270

271

272

273

274

275

276

277

278

279

280

281

282

283

284

285

286

287

288

289

290

291

292

293

294

295

296

297

298

299

300

301

302

303

304

305

306

307

308

309

310

311

312

313

314

315

316

317

318

319

320

321

322

323

324

325

326

327

328

329

330

331

332

333

334

335

336

337

338

339

340

341

342

343

344

345

346

347

348

349

350

351

352

353

354

355

356

357

358

359

360

361

362

363

364

365

366

367

368

369

370

371

372

373

374

375

376

377

378

379

380

381

382

383

384

385

386

387

388

389

390

391

392

393

394

395

396

397

398

399

400

401

402

403

404

405

406

407

408

409

410

411

412

413

414

415

416

417

418

419

420

421

422

423

424

425

426

427

428

429

430

431

432

433

434

435

436

437

438

439

440

441

442

443

444

445

446

447

448

449

450

451

452

453

454

455

456

457

458

459

460

461

462

463

464

465

466

467

468

469

470

471

472

473

474

475

476

477

478

479

480

481

482

483

484

485

486

487

488

489

490

491

492

493

494

495

496

497

498

499

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	I	E	R	G	K	F	R	S	L	T	L	I	N	W	N	G	F	F	A	R	T	F	D	L	D	E	L	V	T	T	L	S	G	G	N	G	A	G	K	S	T	T	M	A	A	F	V	T	A	L	I	P	D	L	T	L	L	H	F
Secondary structure
SS confidence
Disorder	?	?	?	?	?																																																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	R	N	T	T	E	A	G	A	T	S	G	S	R	D	K	G	L	H	G	K	L	K	A	G	V	C	Y	S	M	L	D	T	I	N	S	R	H	Q	R	V	V	V	G	V	R	L	Q	Q	V	A	G	R	D	R	K	V	D	I	K	P
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?																												?		?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	F	A	I	Q	G	L	P	M	S	V	Q	P	T	Q	L	V	T	E	T	L	N	E	R	Q	A	R	V	L	P	L	N	E	L	K	D	K	L	E	A	M	E	G	V	Q	F	K	Q	F	N	S	I	T	D	Y	H	S	L	M	F	D
Secondary structure
SS confidence
Disorder							?	?		?									?	?	?	?	?	?	?	?	?	?	?																															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	L	G	I	I	A	R	R	L	R	S	A	S	D	R	S	K	F	Y	R	L	I	E	A	S	L	Y	G	G	I	S	S	A	I	T	R	S	L	R	D	Y	L	L	P	E	N	S	G	V	R	K	A	F	Q	D	M	E	A	A	L	R
Secondary structure
SS confidence
Disorder	?	?	?	?				?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	N	R	M	T	L	E	A	I	R	V	T	Q	S	D	R	D	L	F	K	H	L	I	S	E	A	T	N	Y	V	A	A	D	Y	M	R	H	A	N	E	R	R	V	H	L	D	K	A	L	E	F	R	R	E	L	H	T	S	R	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	Q	L	A	A	E	Q	Y	K	H	V	D	M	A	R	E	L	A	E	H	N	G	A	E	G	D	L	E	A	D	Y	Q	A	A	S	D	H	L	N	L	V	Q	T	A	L	R	Q	Q	E	K	I	E	R	Y	E	A	D	L	D	E	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Q	I	R	L	E	E	Q	N	E	V	V	A	E	A	I	E	R	Q	Q	E	N	E	A	R	A	E	A	A	E	L	E	V	D	E	L	K	S	Q	L	A	D	Y	Q	Q	A	L	D	V	Q	Q	T	R	A	I	Q	Y	N	Q	A	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	A	A	L	N	R	A	K	E	L	C	H	L	P	D	L	T	A	D	C	A	A	E	W	L	E	T	F	Q	A	K	E	L	E	A	T	E	K	M	L	S	L	E	Q	K	M	S	M	A	Q	T	A	H	S	Q	F	E	Q	A	Y	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	L	V	V	A	I	N	G	P	L	A	R	N	E	A	W	D	V	A	R	E	L	L	R	E	G	V	D	Q	R	H	L	A	E	Q	V	Q	P	L	R	M	R	L	S	E	L	E	Q	R	L	R	E	Q	Q	E	A	E	R	L	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	D	F	C	K	R	Q	G	K	N	F	D	I	D	E	L	E	A	L	H	Q	E	L	E	A	R	I	A	S	L	S	D	S	V	S	N	A	R	E	E	R	M	A	L	R	Q	E	Q	E	Q	L	Q	S	R	I	Q	S	L	M	Q	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	A	P	V	W	L	A	A	Q	N	S	L	N	Q	L	S	E	Q	C	G	E	E	F	T	S	S	Q	D	V	T	E	Y	L	Q	Q	L	L	E	R	E	R	E	A	I	V	E	R	D	E	V	G	A	R	K	N	A	V	D	E	E	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	E	R	L	S	Q	P	G	G	S	E	D	Q	R	L	N	A	L	A	E	R	F	G	G	V	L	L	S	E	I	Y	D	D	V	S	L	E	D	A	P	Y	F	S	A	L	Y	G	P	S	R	H	A	I	V	V	P	D	L	S	Q	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	T	E	H	L	E	G	L	T	D	C	P	E	D	L	Y	L	I	E	G	D	P	Q	S	F	D	D	S	V	F	S	V	D	E	L	E	K	A	V	V	V	K	I	A	D	R	Q	W	R	Y	S	R	F	P	E	V	P	L	F	G	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	A	A	R	E	S	R	I	E	S	L	H	A	E	R	E	V	L	S	E	R	F	A	T	L	S	F	D	V	Q	K	T	Q	R	L	H	Q	A	F	S	R	F	I	G	S	H	L	A	V	A	F	E	S	D	P	E	A	E	I	R	Q
Secondary structure
SS confidence
Disorder																																																			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	L	N	S	R	R	V	E	L	E	R	A	L	S	N	H	E	N	D	N	Q	Q	Q	R	I	Q	F	E	Q	A	K	E	G	V	T	A	L	N	R	I	L	P	R	L	N	L	L	A	D	D	S	L	A	D	R	V	D	E	I	R	E
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	R	L	D	E	A	Q	E	A	A	R	F	V	Q	Q	F	G	N	Q	L	A	K	L	E	P	I	V	S	V	L	Q	S	D	P	E	Q	F	E	Q	L	K	E	D	Y	A	Y	S	Q	Q	M	Q	R	D	A	R	Q	Q	A	F	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	T	E	V	V	Q	R	R	A	H	F	S	Y	S	D	S	A	E	M	L	S	G	N	S	D	L	N	E	K	L	R	E	R	L	E	Q	A	E	A	E	R	T	R	A	R	E	A	L	R	G	H	A	A	Q	L	S	Q	Y	N	Q	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	L	A	S	L	K	S	S	Y	D	T	K	K	E	L	L	N	D	L	Q	R	E	L	Q	D	I	G	V	R	A	D	S	G	A	E	E	R	A	R	I	R	R	D	E	L	H	A	Q	L	S	N	N	R	S	R	R	N	Q	L	E	K
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	A	L	T	F	C	E	A	E	M	D	N	L	T	R	K	L	R	K	L	E	R	D	Y	F	E	M	R	E	Q	V	V	T	A	K	A	G	W	C	A	V	M	R	M	V	K	D	N	G	V	E	R	R	L	H	R	R	E	L	A	Y
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	L	S	A	D	D	L	R	S	M	S	D	K	A	L	G	A	L	R	L	A	V	A	D	N	E	H	L	R	D	V	L	R	M	S	E	D	P	K	R	P	E	R	K	I	Q	F	F	V	A	V	Y	Q	H	L	R	E	R	I	R	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	D	I	I	R	T	D	D	P	V	E	A	I	E	Q	M	E	I	E	L	S	R	L	T	E	E	L	T	S	R	E	Q	K	L	A	I	S	S	R	S	V	A	N	I	I	R	K	T	I	Q	R	E	Q	N	R	I	R	M	L	N	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	G	L	Q	N	V	S	F	G	Q	V	N	S	V	R	L	N	V	N	V	R	E	T	H	A	M	L	L	D	V	L	S	E	Q	H	E	Q	H	Q	D	L	F	N	S	N	R	L	T	F	S	E	A	L	A	K	L	Y	Q	R	L	N
Secondary structure
SS confidence
Disorder					?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	P	Q	I	D	M	G	Q	R	T	P	Q	T	I	G	E	E	L	L	D	Y	R	N	Y	L	E	M	E	V	E	V	N	R	G	S	D	G	W	L	R	A	E	S	G	A	L	S	T	G	E	A	I	G	T	G	M	S	I	L	V	M
Secondary structure
SS confidence
Disorder																			?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	V	V	Q	S	W	E	D	E	S	R	R	L	R	G	K	D	I	S	P	C	R	L	L	F	L	D	E	A	A	R	L	D	A	R	S	I	A	T	L	F	E	L	C	E	R	L	Q	M	Q	L	I	I	A	A	P	E	N	I	S	P
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?								?				?	?	?		?	?																				?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.
Sequence	E	K	G	T	T	Y	K	L	V	R	K	V	F	Q	N	T	E	H	V	H	V	V	G	L	R	G	F	A	P	Q	L	P	E	T	L	P	G	T	D	E	A	P	S	Q	A	S
Secondary structure
SS confidence
Disorder	?	?	?	?												?																					?	?	?	?	?	?	?	?	?	?
Disorder confidence