PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2pzfB_

Fold library id	PDB Header	Molecule	Title
c2pzfB_	PDB header: hydrolase	Chain: B: PDB Molecule: cystic fibrosis transmembrane conductance regulator;	PDBTitle: minimal human cftr first nucleotide binding domain as a head-to-tail2 dimer with delta f508

Links to external resources
Added to library: Tue Mar 16 12:40:57 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence T T T E V V M E N V T A F W E E G G T P V L K D I N F K I E R G Q L L A V A G S T G A G K T S L L M M I M G E L E P S E G K I K H S G R I S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S T T S
S T T
S T T S S T T S S
S
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence F C S Q F S W I M P G T I K E N I I G V S Y D E Y R Y R S V I K A C Q L E E D I S K F A E K D N I V L G E G G I T L S G G Q R A R I S L A R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S T T
T T
T T S T T G G G
T T
T T S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence A V Y K D A D L Y L L D S P F G Y L D V L T E K E I F E S C V C K L M A N K T R I L V T S K M E H L K K A D K I L I L H E G S S Y F Y G T F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
S S T T T T S
T T T S
S T T

. . . . . .

Sequence S E L Q N L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	T	T	T	E	V	V	M	E	N	V	T	A	F	W	E	E	G	G	T	P	V	L	K	D	I	N	F	K	I	E	R	G	Q	L	L	A	V	A	G	S	T	G	A	G	K	T	S	L	L	M	M	I	M	G	E	L	E	P	S	E	G	K	I	K	H	S	G	R	I	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														S	S	T	T	S			S										T	T								S	T	T	S	S									T	T	S	S			S								S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	F	C	S	Q	F	S	W	I	M	P	G	T	I	K	E	N	I	I	G	V	S	Y	D	E	Y	R	Y	R	S	V	I	K	A	C	Q	L	E	E	D	I	S	K	F	A	E	K	D	N	I	V	L	G	E	G	G	I	T	L	S	G	G	Q	R	A	R	I	S	L	A	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T					S									T	T														T	T						T	T	S	T	T	G	G	G					T	T		T	T	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	A	V	Y	K	D	A	D	L	Y	L	L	D	S	P	F	G	Y	L	D	V	L	T	E	K	E	I	F	E	S	C	V	C	K	L	M	A	N	K	T	R	I	L	V	T	S	K	M	E	H	L	K	K	A	D	K	I	L	I	L	H	E	G	S	S	Y	F	Y	G	T	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S			S						S	T	T	T	T	S																	T	T	T	S																S							T	T
	.	.	.	.	.	.
Sequence	S	E	L	Q	N	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)