Phyre 2 Results for Q92569

Email	l.a.kelley@imperial.ac.uk
Description	Q92569
Date	Fri May 25 09:38:24 BST 2012
Unique Job ID	3a30478d3fb3e090

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2oq1A_

Top template information

PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Confidence and coverage

Confidence:

100.0%

Coverage:

53%

246 residues ( 53% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

301 residues ( 65%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M Y N T V W S M D R D D A D W R E V M M P Y S T E L I F Y I E M D P P A L P P K P P K P M T S A V P N G M K D S S V S L

Secondary structure

SS confidence

Disorder ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence Q D A E W Y W G D I S R E E V N D K L R D M P D G T F L V R D A S T K M Q G D Y T L T L R K G G N N K L I K I Y H R D G

Secondary structure

SS confidence

Disorder
? ?
?
? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence K Y G F S D P L T F N S V V E L I N H Y H H E S L A Q Y N P K L D V K L M Y P V S R Y Q Q D Q L V K E D N I D A V G K K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence L Q E Y H S Q Y Q E K S K E Y D R L Y E E Y T R T S Q E I Q M K R T A I E A F N E T I K I F E E Q C H T Q E Q H S K E Y

Secondary structure

SS confidence

Disorder
? ? ? ? ?
?
?
? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence I E R F R R E G N E K E I E R I M M N Y D K L K S R L G E I H D S K M R L E Q D L K N Q A L D N R E I D K K M N S I K P

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ?
?
?
?
? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence D L I Q L R K I R D Q H L V W L N H K G V R Q K R L N V W L G I K N E D A D E N Y F I N E E D E N L P H Y D E K T W F V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence E D I N R V Q A E D L L Y G K P D G A F L I R E S S K K G C Y A C S V V A D G E V K H C V I Y S T A R G Y G F A E P Y N

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 .

Sequence L Y S S L K E L V L H Y Q Q T S L V Q H N D S L N V R L A Y P V H A Q M P S L C R

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2oq1 chain A

Region: 59 - 452
Aligned: 246
Modelled: 257
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2shp chain A

Region: 61 - 453
Aligned: 202
Modelled: 205
Confidence: 100.0%
Identity: 31%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2b3o chain A

Region: 64 - 453
Aligned: 199
Modelled: 202
Confidence: 100.0%
Identity: 35%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 3ps5 chain A

Region: 65 - 453
Aligned: 198
Modelled: 201
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 1a81 chain E

Region: 59 - 452
Aligned: 212
Modelled: 223
Confidence: 100.0%
Identity: 35%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 2ozo chain A

Region: 57 - 454
Aligned: 250
Modelled: 261
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 3gqi chain B

Region: 62 - 455
Aligned: 197
Modelled: 207
Confidence: 100.0%
Identity: 44%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 2y3a chain B

Region: 184 - 455
Aligned: 233
Modelled: 239
Confidence: 100.0%
Identity: 76%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 3hiz chain B

Region: 59 - 311
Aligned: 234
Modelled: 238
Confidence: 100.0%
Identity: 83%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 1pic chain A

Region: 347 - 458
Aligned: 112
Modelled: 112
Confidence: 99.9%
Identity: 76%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1qad chain A

Region: 348 - 454
Aligned: 104
Modelled: 107
Confidence: 99.9%
Identity: 82%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 3or8 chain A

Region: 62 - 434
Aligned: 166
Modelled: 172
Confidence: 99.9%
Identity: 28%
PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6

Phyre2

PDB 2crh chain A

Region: 38 - 166
Aligned: 128
Modelled: 129
Confidence: 99.9%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 2oq1 chain A domain 1

Region: 351 - 457
Aligned: 102
Modelled: 107
Confidence: 99.9%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2eo6 chain A

Region: 351 - 458
Aligned: 108
Modelled: 108
Confidence: 99.9%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2oq1 chain A domain 2

Region: 349 - 453
Aligned: 100
Modelled: 105
Confidence: 99.9%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1a81 chain E domain 2

Region: 353 - 454
Aligned: 97
Modelled: 102
Confidence: 99.9%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1a81 chain A domain 1

Region: 352 - 459
Aligned: 103
Modelled: 108
Confidence: 99.9%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1a81 chain A domain 2

Region: 353 - 459
Aligned: 98
Modelled: 107
Confidence: 99.9%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2c9w chain A

Region: 354 - 461
Aligned: 101
Modelled: 108
Confidence: 99.9%
Identity: 25%
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Phyre2

PDB 1k9a chain B

Region: 6 - 165
Aligned: 129
Modelled: 129
Confidence: 99.8%
Identity: 24%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

100

101

102

103

104

105

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108

109

110

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112

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247

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	Y	N	T	V	W	S	M	D	R	D	D	A	D	W	R	E	V	M	M	P	Y	S	T	E	L	I	F	Y	I	E	M	D	P	P	A	L	P	P	K	P	P	K	P	M	T	S	A	V	P	N	G	M	K	D	S	S	V	S	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?		?		?	?	?	?	?	?	?	?	?	?	?		?	?		?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	Q	D	A	E	W	Y	W	G	D	I	S	R	E	E	V	N	D	K	L	R	D	M	P	D	G	T	F	L	V	R	D	A	S	T	K	M	Q	G	D	Y	T	L	T	L	R	K	G	G	N	N	K	L	I	K	I	Y	H	R	D	G
Secondary structure
SS confidence
Disorder																							?	?										?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	K	Y	G	F	S	D	P	L	T	F	N	S	V	V	E	L	I	N	H	Y	H	H	E	S	L	A	Q	Y	N	P	K	L	D	V	K	L	M	Y	P	V	S	R	Y	Q	Q	D	Q	L	V	K	E	D	N	I	D	A	V	G	K	K
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	L	Q	E	Y	H	S	Q	Y	Q	E	K	S	K	E	Y	D	R	L	Y	E	E	Y	T	R	T	S	Q	E	I	Q	M	K	R	T	A	I	E	A	F	N	E	T	I	K	I	F	E	E	Q	C	H	T	Q	E	Q	H	S	K	E	Y
Secondary structure
SS confidence
Disorder			?	?	?	?	?		?			?												?	?	?	?	?	?	?	?	?	?	?											?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	I	E	R	F	R	R	E	G	N	E	K	E	I	E	R	I	M	M	N	Y	D	K	L	K	S	R	L	G	E	I	H	D	S	K	M	R	L	E	Q	D	L	K	N	Q	A	L	D	N	R	E	I	D	K	K	M	N	S	I	K	P
Secondary structure
SS confidence
Disorder																																	?		?	?	?	?	?	?	?	?		?		?		?				?	?		?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	D	L	I	Q	L	R	K	I	R	D	Q	H	L	V	W	L	N	H	K	G	V	R	Q	K	R	L	N	V	W	L	G	I	K	N	E	D	A	D	E	N	Y	F	I	N	E	E	D	E	N	L	P	H	Y	D	E	K	T	W	F	V
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	E	D	I	N	R	V	Q	A	E	D	L	L	Y	G	K	P	D	G	A	F	L	I	R	E	S	S	K	K	G	C	Y	A	C	S	V	V	A	D	G	E	V	K	H	C	V	I	Y	S	T	A	R	G	Y	G	F	A	E	P	Y	N
Secondary structure
SS confidence
Disorder																?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Sequence	L	Y	S	S	L	K	E	L	V	L	H	Y	Q	Q	T	S	L	V	Q	H	N	D	S	L	N	V	R	L	A	Y	P	V	H	A	Q	M	P	S	L	C	R
Secondary structure
SS confidence
Disorder																		?	?	?	?														?	?	?	?	?	?	?
Disorder confidence