Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9Z0R4
DateTue Jul 30 13:06:10 BST 2013
Unique Job ID298496d1861f1601
SequenceMAQFPTPFGG ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:70.892 Y:67.280 Z:68.591
Model (left) based on template c2dx1A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
Confidence and coverage
Confidence:100.0% Coverage: 21%
364 residues ( 21% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
795 residues ( 46%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol
For other options to view your downloaded structure offline see the FAQ

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MAQFPTPFGGSLDVWAITVEERAKHDQQFLSLKPIAGFITGDQARNFFFQSGLPQPVLAQ
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   .........70.........80.........90.........100.........110.........120
Sequence  IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSTLPPVMKQQPVAISSAPAFGIGGI
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   .........130.........140.........150.........160.........170.........180
Sequence  ASMPPLTAVAPVPMGSIPVVGMSPPLVSSVPPAAVPPLANGAPPVIQPLPAFAHPAATWP
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   .........190.........200.........210.........220.........230.........240
Sequence  KSSSFSRSGPGSQLNTKLQKAQSFDVASAPPAAEWAVPQSSRLKYRQLFNSHDKTMSGHL
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   .........250.........260.........270.........280.........290.........300
Sequence  TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP
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   .........310.........320.........330.........340.........350.........360
Sequence  PEYIPPSFRRVRSGSGMSVISSSSVDQRLPEEPSSEDEQQPEKKLPVTFEDKKRENFERG
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   .........370.........380.........390.........400.........410.........420
Sequence  SVELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQEAKRQLELEKQLEKQRELER
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   .........430.........440.........450.........460.........470.........480
Sequence  QREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEGTVVLKARRKTLEFE
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   .........490.........500.........510.........520.........530.........540
Sequence  LEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRL
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   .........550.........560.........570.........580.........590.........600
Sequence  IPEKQILSDQLKQVQQNSLHRDSLLTLKRALEAKELARQQLREQLDEVERETRSKLQEID
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   .........610.........620.........630.........640.........650.........660
Sequence  VFNNQLKELREIHSKQQLQKQRSLEAARLKQKEQERKSLELEKQKEDAQRRVQERDKQWL
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   .........670.........680.........690.........700.........710.........720
Sequence  EHVQQEEQPRPRKPHEEDRLKREDSVRKKEAEERAKPEMQDKQSRLFHPHQEPAKLATQA
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   .........730.........740.........750.........760.........770.........780
Sequence  PWSTTEKGPLTISAQESVKVVYYRALYPFESRSHDEITIQPGDIVMVDESQTGEPGWLGG
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   .........790.........800.........810.........820.........830.........840
Sequence  ELKGKTGWFPANYAEKIPENEVPTPAKPVTDLTSAPAPKLALRETPAPLPVTSSEPSTTP
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   .........850.........860.........870.........880.........890.........900
Sequence  NNWADFSSTWPSSSNEKPETDNWDTWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVL
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   .........910.........920.........930.........940.........950.........960
Sequence  GQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWWFGEVQGQKGWFPKSYVK
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   .........970.........980.........990.........1000.........1010.........1020
Sequence  LISGPVRKSTSIDTGPTESPASLKRVASPAAKPAIPGEEFIAMYTYESSEQGDLTFQQGD
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   .........1030.........1040.........1050.........1060.........1070.........1080
Sequence  VIVVTKKDGDWWTGTVGDKSGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYAA
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   .........1090.........1100.........1110.........1120.........1130.........1140
Sequence  TGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTE
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   .........1150.........1160.........1170.........1180.........1190.........1200
Sequence  LPKTAVQPAVCQVIGMYDYTAQNDDELAFSKGQIINVLNKEDPDWWKGEVSGQVGLFPSN
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   .........1210.........1220.........1230.........1240.........1250.........1260
Sequence  YVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPL
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   .........1270.........1280.........1290.........1300.........1310.........1320
Sequence  TESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQ
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   .........1330.........1340.........1350.........1360.........1370.........1380
Sequence  PYIRFCSCQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPL
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   .........1390.........1400.........1410.........1420.........1430.........1440
Sequence  IIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSE
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   .........1450.........1460.........1470.........1480.........1490.........1500
Sequence  QLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSP
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   .........1510.........1520.........1530.........1540.........1550.........1560
Sequence  KSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIK
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   .........1570.........1580.........1590.........1600.........1610.........1620
Sequence  AASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGS
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   .........1630.........1640.........1650.........1660.........1670.........1680
Sequence  QCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKK
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   .........1690.........1700.........1710....
Sequence  DQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP
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Confidence Key
High(9)                    Low (0)
?Disordered ( 44%)
Alpha helix ( 40%)
Beta strand ( 11%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2dx1 chain A

3D model

Region: 1153 - 1566
Aligned: 364
Modelled: 386
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 3jv3 chain A

3D model

Region: 1149 - 1426
Aligned: 278
Modelled: 278
Confidence: 100.0%
Identity: 99%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l

Phyre2

PDB 3odo chain A

3D model

Region: 1207 - 1563
Aligned: 354
Modelled: 357
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef

Phyre2

PDB 1x86 chain A

3D model

Region: 1209 - 1569
Aligned: 348
Modelled: 361
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa

Phyre2

PDB 1ki1 chain B

3D model

Region: 1222 - 1574
Aligned: 342
Modelled: 353
Confidence: 100.0%
Identity: 94%
PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42

Phyre2

PDB 3ky9 chain B

3D model

Region: 1225 - 1574
Aligned: 316
Modelled: 333
Confidence: 100.0%
Identity: 19%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 1xcg chain A

3D model

Region: 1211 - 1565
Aligned: 339
Modelled: 355
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef

Phyre2

PDB 3ksy chain A

3D model

Region: 1231 - 1565
Aligned: 319
Modelled: 335
Confidence: 100.0%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)

Phyre2

PDB 3t06 chain E

3D model

Region: 1210 - 1564
Aligned: 342
Modelled: 355
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa

Phyre2

PDB 2vrw chain B

3D model

Region: 1226 - 1574
Aligned: 313
Modelled: 332
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor

Phyre2

PDB 2dfk chain A

3D model

Region: 1222 - 1584
Aligned: 338
Modelled: 349
Confidence: 100.0%
Identity: 20%
PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex

Phyre2

PDB 4gou chain A

3D model

Region: 1222 - 1562
Aligned: 322
Modelled: 341
Confidence: 100.0%
Identity: 15%
PDB header:signaling protein
Chain: A: PDB Molecule:ehrgs-rhogef;
PDBTitle: crystal structure of an rgs-rhogef from entamoeba histolytica

Phyre2

PDB 1xdv chain B

3D model

Region: 1231 - 1563
Aligned: 313
Modelled: 314
Confidence: 100.0%
Identity: 17%
PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.

Phyre2

PDB 1foe chain A

3D model

Region: 1227 - 1570
Aligned: 336
Modelled: 344
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1

Phyre2

PDB 2z0q chain A

3D model

Region: 1222 - 1564
Aligned: 304
Modelled: 329
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)

Phyre2

PDB 3bji chain A

3D model

Region: 1226 - 1574
Aligned: 315
Modelled: 332
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1

Phyre2

PDB 4gzu chain B

3D model

Region: 1230 - 1564
Aligned: 294
Modelled: 321
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: B: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp2

Phyre2

PDB 3odw chain B

3D model

Region: 1226 - 1567
Aligned: 322
Modelled: 328
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef

Phyre2

PDB 3odx chain A

3D model

Region: 1226 - 1566
Aligned: 326
Modelled: 341
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef

Phyre2

PDB 4h6y chain A

3D model

Region: 1230 - 1564
Aligned: 287
Modelled: 317
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 1;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp1

Phyre2

PDB 2khn chain A

3D model

Region: 1 - 111
Aligned: 111
Modelled: 111
Confidence: 99.9%
Identity: 96%
PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.

Phyre2

PDB 3fia chain A

3D model

Region: 6 - 103
Aligned: 98
Modelled: 94
Confidence: 99.8%
Identity: 92%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.

Phyre2

PDB 1gri chain A

3D model

Region: 999 - 1208
Aligned: 203
Modelled: 203
Confidence: 99.5%
Identity: 25%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 3jzy chain A

3D model

Region: 1588 - 1711
Aligned: 124
Modelled: 124
Confidence: 99.5%
Identity: 73%
PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain

Phyre2

PDB 2lqn chain A

3D model

Region: 973 - 1214
Aligned: 201
Modelled: 201
Confidence: 99.4%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2eyz chain A

3D model

Region: 968 - 1214
Aligned: 197
Modelled: 197
Confidence: 99.4%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2l3s chain A

3D model

Region: 997 - 1207
Aligned: 161
Modelled: 161
Confidence: 99.3%
Identity: 25%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2
1

c2dx1A_
2

c3jv3A_
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c3odoA_
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c1x86A_
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c1ki1B_
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c3ky9B_
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c1xcgA_
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c3ksyA_
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c3t06E_
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c2vrwB_
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c2dfkA_
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c4gouA_
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c1xdvB_
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c1foeA_
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c2z0qA_
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c3bjiA_
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c4gzuB_
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c3odwB_
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c3odxA_
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c4h6yA_
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c2khnA_
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c3fiaA_
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c1griA_
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c3jzyA_
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c2lqnA_
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c2eyzA_
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c2l3sA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2dx1A_



100.0 22 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
2c3jv3A_



100.0 99 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l
3c3odoA_



100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef
4c1x86A_



100.0 27 PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa
5c1ki1B_



100.0 94 PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42
6c3ky9B_



100.0 19 PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
7c1xcgA_



100.0 28 PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef
8c3ksyA_



100.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)
9c3t06E_



100.0 28 PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa
10c2vrwB_



100.0 21 PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor
11c2dfkA_



100.0 20 PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex
12c4gouA_



100.0 15 PDB header:signaling protein
Chain: A: PDB Molecule:ehrgs-rhogef;
PDBTitle: crystal structure of an rgs-rhogef from entamoeba histolytica
13c1xdvB_



100.0 17 PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.
14c1foeA_



100.0 21 PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1
15c2z0qA_



100.0 28 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)
16c3bjiA_



100.0 19 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1
17c4gzuB_



100.0 24 PDB header:signaling protein
Chain: B: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp2
18c3odwB_



100.0 26 PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef
19c3odxA_



100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef
20c4h6yA_



100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 1;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp1
21c1dbhA_



not modelled 100.0 16 PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1
22c2rgnB_



not modelled 100.0 17 PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa
23c1lb1C_



not modelled 100.0 19 PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa
24c3mpxA_



not modelled 100.0 20 PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5
25c1ntyA_



not modelled 100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:triple functional domain protein;
PDBTitle: crystal structure of the first dh/ph domain of trio to 1.7 a
26d1xcga1



not modelled 100.0 30 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
27d1txda1



not modelled 100.0 28 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
28d1ki1b1



not modelled 100.0 99 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
29c4gyvA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh domain of farp2
30d2dfka1



not modelled 99.9 20 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
31d1dbha1



not modelled 99.9 16 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
32c3eo2A_



not modelled 99.9 32 PDB header:splicing
Chain: A: PDB Molecule:neuroepithelial cell-transforming gene 1 protein;
PDBTitle: crystal structure of the rhogef domain of human neuroepithelial cell-2 transforming gene 1 protein
33d1foea1



not modelled 99.9 25 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
34c3gf9A_



not modelled 99.9 80 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 rhogef domain
35d1by1a_



not modelled 99.9 20 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
36d1f5xa_



not modelled 99.9 24 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
37d1kz7a1



not modelled 99.9 23 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
38d1ntya1



not modelled 99.9 24 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
39c2khnA_



99.9 96 PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.
40c3fiaA_



99.8 92 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.
41c2jq6A_



not modelled 99.8 36 PDB header:metal binding protein
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of eh-domain of ehd1
42c2kfhA_



not modelled 99.7 38 PDB header:protein binding
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of the c-terminal domain of ehd1 with fnyestgpftak
43d2jxca1



not modelled 99.7 36 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
44c2qptA_



not modelled 99.7 33 PDB header:endocytosis
Chain: A: PDB Molecule:eh domain-containing protein-2;
PDBTitle: crystal structure of an ehd atpase involved in membrane remodelling
45c2kgrA_



not modelled 99.6 37 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: solution structure of protein itsn1 from homo sapiens.2 northeast structural genomics consortium target hr5524a
46d1iq3a_



not modelled 99.6 38 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
47d1fi6a_



not modelled 99.6 40 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
48d1c07a_



not modelled 99.6 36 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
49c1griA_



99.5 25 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
50c3jzyA_



99.5 73 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain
51c2lg1A_



not modelled 99.5 19 PDB header:metal binding protein
Chain: A: PDB Molecule:a-kinase anchor protein 13;
PDBTitle: solution structure of the human akap13 ph domain and stabilizing dh2 helix
52d1qjta_



not modelled 99.4 22 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
53d1ki1b2



not modelled 99.4 89 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
54c2lqnA_



99.4 23 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
55c2eyzA_



99.4 23 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
56c2fk9A_



not modelled 99.4 24 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta
57c2l3sA_



99.3 25 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
58c2nq3A_



not modelled 99.2 24 PDB header:ligase
Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase;
PDBTitle: crystal structure of the c2 domain of human itchy homolog2 e3 ubiquitin protein ligase
59d2nq3a1



not modelled 99.2 24 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
60c1mv3A_



not modelled 99.2 14 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
61c1ng2A_



not modelled 99.2 27 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
62c1ov3A_



not modelled 99.2 26 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
63d1gmia_



not modelled 99.1 25 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
64c3nsjA_



not modelled 99.1 25 PDB header:immune system
Chain: A: PDB Molecule:perforin-1;
PDBTitle: the x-ray crystal structure of lymphocyte perforin
65d2ep6a1



not modelled 99.0 33 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
66d1bdya_



not modelled 99.0 18 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
67d1wfja_



not modelled 99.0 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
68c2dmhA_



not modelled 99.0 23 PDB header:lipid binding protein
Chain: A: PDB Molecule:myoferlin;
PDBTitle: solution structure of the first c2 domain of human myoferlin
69c3l9bA_



not modelled 99.0 16 PDB header:membrane protein
Chain: A: PDB Molecule:otoferlin;
PDBTitle: crystal structure of rat otoferlin c2a
70c2jqzA_



not modelled 99.0 27 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf2;
PDBTitle: solution structure of the c2 domain of human smurf2
71c3kwtA_



not modelled 99.0 28 PDB header:metal binding protein
Chain: A: PDB Molecule:munc13-1;
PDBTitle: munc13-1 c2b-domain, calcium-free
72d1udla_



not modelled 98.9 65 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
73d2cjsa1



not modelled 98.9 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
74c3m7fB_



not modelled 98.9 31 PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex
75d1rlwa_



not modelled 98.9 18 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
76d1dsya_



not modelled 98.9 29 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
77c2enjA_



not modelled 98.8 19 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c theta type;
PDBTitle: solution sturcture of the c2 domain from human protein2 kinase c theta
78c1dqvA_



not modelled 98.8 23 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin iii;
PDBTitle: crystal structure of synaptotagmin iii c2a/c2b
79d1xcga2



not modelled 98.8 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
80d1ng2a2



not modelled 98.8 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
81d1zc3b1



not modelled 98.8 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
82d1qasa2



not modelled 98.7 22 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
83d2dfka2



not modelled 98.7 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
84c2r83B_



not modelled 98.7 23 PDB header:endocytosis, exocytosis
Chain: B: PDB Molecule:synaptotagmin-1;
PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b
85c2d8kA_



not modelled 98.7 27 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin vii;
PDBTitle: solution structure of the first c2 domain of synaptotagmin2 vii
86c2nsqA_



not modelled 98.7 27 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein;
PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein
87c3qwmA_



not modelled 98.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:iq motif and sec7 domain-containing protein 1;
PDBTitle: crystal structure of gep100, the plextrin homology domain of iq motif2 and sec7 domain-containing protein 1 isoform a
88d1txda2



not modelled 98.7 25 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
89d1dbha2



not modelled 98.7 19 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
90c3nmzD_



not modelled 98.7 25 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
91c2chdA_



not modelled 98.6 30 PDB header:protein transport
Chain: A: PDB Molecule:rabphilin-3a;
PDBTitle: crystal structure of the c2a domain of rabphilin-3a
92c1x2qA_



not modelled 98.6 31 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
93d2r83a1



not modelled 98.6 24 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
94d1a25a_



not modelled 98.6 28 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
95c2cubA_



not modelled 98.6 29 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
96c2rqrA_



not modelled 98.6 7 PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex
97c2eyyA_



not modelled 98.6 23 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
98c2ed0A_



not modelled 98.6 35 PDB header:signaling protein
Chain: A: PDB Molecule:abl interactor 2;
PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2)
99c2enpA_



not modelled 98.6 23 PDB header:transport protein
Chain: A: PDB Molecule:b/k protein;
PDBTitle: solution structure of the first c2 domain from human b/k2 protein
100d1ov3a2



not modelled 98.6 26 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
101c2dbkA_



not modelled 98.6 28 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structures of the sh3 domain of human crk-like2 protein
102c2ysqA_



not modelled 98.6 24 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9;
PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9
103c2jxbA_



not modelled 98.6 29 PDB header:signaling protein complex
Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain,
PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
104c2oi3A_



not modelled 98.6 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1)
105c2yunA_



not modelled 98.6 25 PDB header:protein transport
Chain: A: PDB Molecule:nostrin;
PDBTitle: solution structure of the sh3 domain of human nostrin
106c2dlpA_



not modelled 98.6 27 PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
107c2ebpA_



not modelled 98.6 23 PDB header:cell adhesion
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1
108d1rsya_



not modelled 98.5 28 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
109c2l0aA_



not modelled 98.5 42 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 1;
PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e
110c3fbkB_



not modelled 98.5 22 PDB header:signaling protein
Chain: B: PDB Molecule:regulator of g-protein signaling 3;
PDBTitle: crystal structure of the c2 domain of the human regulator2 of g-protein signaling 3 isoform 6 (rgp3), northeast3 structural genomics consortium target hr5550a
111d1wiea_



not modelled 98.5 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
112c2yt6A_



not modelled 98.5 27 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
113c2dl8A_



not modelled 98.5 27 PDB header:signaling protein
Chain: A: PDB Molecule:slit-robo rho gtpase-activating protein 2;
PDBTitle: solution structure of the sh3 domain of human slit-robo rho2 gtpase-activating protein 2
114c2yupA_



not modelled 98.5 22 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the second sh3 domain of human vinexin
115c2kymA_



not modelled 98.5 32 PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide
116c2yuoA_



not modelled 98.5 25 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
117c2dnuA_



not modelled 98.5 29 PDB header:structural genomics, structural protein
Chain: A: PDB Molecule:sh3 multiple domains 1;
PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human
118d1wfma_



not modelled 98.5 20 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
119c2djqA_



not modelled 98.5 24 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:sh3 domain containing ring finger 2;
PDBTitle: the solution structure of the first sh3 domain of mouse sh32 domain containing ring finger 2
120d1k4us_



not modelled 98.5 37 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain

Binding site prediction 

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite