Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ8CG80
DateTue Jul 30 13:10:18 BST 2013
Unique Job ID9dad74adf49bf70a
SequenceMEPYEAQKMM ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:34.197 Y:48.233 Z:35.415
Model (left) based on template c2eo6A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
Confidence and coverage
Confidence:100.0% Coverage: 50%
120 residues ( 50% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
3D viewing
Interactive 3D view in Jmol
For other options to view your downloaded structure offline see the FAQ

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MEPYEAQKMMAEIRGSKETAAQPLPLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERP
Secondary structure 
SS confidence 
Disorder  ????????????????????????
???????????????????????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  PEEYDQPWEWKKERISKAFAAQFEGSENCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPS
Secondary structure 
SS confidence 
Disorder  ?
??
??????????
?
????????????????????????????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ
Secondary structure 
SS confidence 
Disorder 
???????
Disorder confidence 
 
   .........190.........200.........210.........220.........230........
Sequence  GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
Secondary structure 
SS confidence 
Disorder 
???????
?????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 50%)
Alpha helix ( 15%)
Beta strand ( 13%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2eo6 chain A

3D model

Region: 114 - 233
Aligned: 120
Modelled: 120
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2hdx chain B

3D model

Region: 132 - 233
Aligned: 99
Modelled: 102
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide

Phyre2

PDB 2y3a chain B

3D model

Region: 133 - 235
Aligned: 101
Modelled: 103
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 2abl chain A

3D model

Region: 82 - 233
Aligned: 147
Modelled: 152
Confidence: 100.0%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 132 - 233
Aligned: 97
Modelled: 102
Confidence: 100.0%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2fo0 chain A

3D model

Region: 82 - 237
Aligned: 151
Modelled: 156
Confidence: 100.0%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 3hiz chain B

3D model

Region: 132 - 233
Aligned: 97
Modelled: 102
Confidence: 99.9%
Identity: 34%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 3c7i chain A domain 1

3D model

Region: 133 - 233
Aligned: 99
Modelled: 101
Confidence: 99.9%
Identity: 29%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2lqn chain A

3D model

Region: 125 - 232
Aligned: 106
Modelled: 108
Confidence: 99.9%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2eo3 chain A

3D model

Region: 132 - 233
Aligned: 95
Modelled: 102
Confidence: 99.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 2gsb chain A

3D model

Region: 127 - 237
Aligned: 105
Modelled: 111
Confidence: 99.9%
Identity: 30%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2

PDB 2crh chain A

3D model

Region: 112 - 233
Aligned: 120
Modelled: 122
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 2shp chain A domain 2

3D model

Region: 134 - 233
Aligned: 98
Modelled: 100
Confidence: 99.9%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1fhs chain A

3D model

Region: 130 - 233
Aligned: 102
Modelled: 104
Confidence: 99.9%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1pic chain A

3D model

Region: 128 - 236
Aligned: 107
Modelled: 109
Confidence: 99.9%
Identity: 26%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2eob chain A

3D model

Region: 120 - 236
Aligned: 110
Modelled: 117
Confidence: 99.9%
Identity: 27%
PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2

Phyre2

PDB 2dly chain A

3D model

Region: 132 - 238
Aligned: 102
Modelled: 107
Confidence: 99.9%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase

Phyre2

PDB 1ka6 chain A

3D model

Region: 133 - 237
Aligned: 101
Modelled: 105
Confidence: 99.9%
Identity: 24%
PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py

Phyre2

PDB 2oq1 chain A

3D model

Region: 132 - 233
Aligned: 97
Modelled: 102
Confidence: 99.9%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2c9w chain A

3D model

Region: 133 - 233
Aligned: 94
Modelled: 101
Confidence: 99.9%
Identity: 24%
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Phyre2
1
c2eo6A_
2
c2hdxB_
3
c2y3aB_
4
c2ablA_
5
d2oq1a1
6
c2fo0A_
7
c3hizB_
8
d3c7ia1
9
c2lqnA_
10
c2eo3A_
11
c2gsbA_
12
c2crhA_
13
d2shpa2
14
d1fhsa_
15
d1pica_
16
c2eobA_
17
c2dlyA_
18
c1ka6A_
19
c2oq1A_
20
c2c9wA_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2eo6A_
100.0 24 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
2c2hdxB_
100.0 25 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
3c2y3aB_
100.0 26 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
4c2ablA_
100.0 24 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
5d2oq1a1
100.0 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
6c2fo0A_
100.0 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
7c3hizB_
99.9 34 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
8d3c7ia1
99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
9c2lqnA_
99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
10c2eo3A_
99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
11c2gsbA_
99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
12c2crhA_
99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
13d2shpa2
99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
14d1fhsa_
99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
15d1pica_
99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
16c2eobA_
99.9 27 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
17c2dlyA_
99.9 31 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
18c1ka6A_
99.9 24 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
19c2oq1A_
99.9 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
20c2c9wA_
99.9 24 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
21c1x6cA_
not modelled 99.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
22c2dlzA_
not modelled 99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
23d1ayaa_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
24c2b3oA_
not modelled 99.9 29 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
25c2vifA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
26c2lctA_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
27d1a81e1
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
28c2hmhA_
not modelled 99.9 22 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
29d1opka2
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1qada_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31c2shpA_
not modelled 99.9 28 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
32c2kk6A_
not modelled 99.9 33 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
33d1k9aa2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34d1a81e2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35d1blja_
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36c2dcrA_
not modelled 99.9 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
37d1rjaa_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d2izva2
not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39c1oplA_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
40d1a81a1
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41d1mila_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d2oq1a2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43d1a81a2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44c2ysxA_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
45c2ci8A_
not modelled 99.9 37 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
46d1d4ta_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d1r1qa_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d2shpa3
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49c1y57A_
not modelled 99.9 19 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
50c2izvA_
not modelled 99.9 22 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
51d1lkka_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
52d1jwoa_
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53c2knoA_
not modelled 99.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
54d2cs0a1
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55c2ozoA_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
56d1luia_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57c2augB_
not modelled 99.9 24 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
58c3nhnA_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
59d1csya_
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d2eyva1
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61d1g83a2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62d1fu6a_
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c1k9aB_
not modelled 99.9 21 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
64d1nrva_
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65c3ps5A_
not modelled 99.9 27 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
66d1i3za_
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67c1x27F_
not modelled 99.9 22 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
68c3gqiB_
not modelled 99.9 21 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
69c4fl2A_
not modelled 99.9 21 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
70d1jyra_
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71c2h8hA_
not modelled 99.9 20 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
72d2qmsa1
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
73c2ekxA_
not modelled 99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
74d1o48a_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75c2c0iA_
not modelled 99.9 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
76d1qcfa2
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d2c9wa2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78d1f2fa_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79c2ge9A_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
80d1bkla_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81d1xa6a2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
82c2el8A_
not modelled 99.9 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
83c1g83A_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
84c3mazA_
not modelled 99.9 11 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
85c1a81E_
not modelled 99.9 18 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
86d2fcia1
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87d1rpya_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88c1rqqC_
not modelled 99.9 25 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
89d1cwea_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
90c2cr4A_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
91c2dm0A_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
92c2eyzA_
not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
93c3gxxB_
not modelled 99.9 19 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
94c2dvjA_
not modelled 99.8 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
95c3qwxX_
not modelled 99.8 25 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
96c2eyyA_
not modelled 99.8 30 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
97c3qwyA_
not modelled 99.8 25 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
98c2dx0B_
not modelled 99.8 33 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
99c3or8A_
not modelled 99.7 19 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
100c1xa6A_
not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
101c2xp1A_
not modelled 99.6 17 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
102d1uura3
not modelled 99.6 11 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
103d1bf5a3
not modelled 99.5 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1bg1a3
not modelled 99.4 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105c3cblA_
not modelled 99.2 36 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
106c1uusA_
not modelled 98.3 16 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
107c2cblA_
not modelled 98.2 17 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
108c3bunB_
not modelled 98.2 17 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
109c1y1uA_
not modelled 98.1 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducer and activator of transcription 5a;
PDBTitle: structure of unphosphorylated stat5a
110c1yvlB_
not modelled 98.0 27 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
111c1bf5A_
not modelled 97.8 22 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
112c1bg1A_
not modelled 97.6 22 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
113c3cwgA_
not modelled 96.6 23 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
114c1griA_
not modelled 94.0 33 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
115c1fbvA_
not modelled 93.0 19 PDB header:ligase
Chain: A: PDB Molecule:signal transduction protein cbl;
PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases
116d3buxb3
not modelled 90.3 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
117c3op0B_
not modelled 86.4 26 PDB header:signaling protein/signaling protein regu
Chain: B: PDB Molecule:signal transduction protein cbl-c;
PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide
118c2yt6A_
not modelled 74.1 19 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
119d2e9ia1
not modelled 65.2 17 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
120d1wlha1
not modelled 63.8 13 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)

Binding site prediction 

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