Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	N	E	N	N	L	I	W	I	D	L	E	M	T	G	L	D	P	E	R	D	R	I	I	E	I	A	T	L	V	T	D	A	N	L	N	I	L	A	E	G	P	T	I	A	V	H	Q	S	D	E	Q	L	A	L	M	D	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	N	V	R	T	H	T	A	S	G	L	V	E	R	V	K	A	S	T	M	G	D	R	E	A	E	L	A	T	L	E	F	L	K	Q	W	V	P	A	G	K	S	P	I	C	G	N	S	I	G	Q	D	R	R	F	L	F	K	Y	M
Secondary structure
SS confidence
Disorder																		?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	E	L	E	A	Y	F	H	Y	R	Y	L	D	V	S	T	L	K	E	L	A	R	R	W	K	P	E	I	L	D	G	F	T	K	Q	G	T	H	Q	A	M	D	D	I	R	E	S	V	A	E	L	A	Y	Y	R	E	H	F	I	K
Secondary structure
SS confidence
Disorder																																				?		?																							?
Disorder confidence
		.
Sequence		L
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2igi chain A domain 1 Region: 2 - 181 Aligned: 180 Modelled: 180 Confidence: 100.0% Identity: 100% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 1j9a chain A Region: 1 - 181 Aligned: 181 Modelled: 177 Confidence: 100.0% Identity: 71% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 3tr8 chain A Region: 1 - 181 Aligned: 181 Modelled: 180 Confidence: 100.0% Identity: 59% PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: structure of an oligoribonuclease (orn) from coxiella burnetii Phyre2 PDB 2gbz chain A Region: 5 - 176 Aligned: 172 Modelled: 172 Confidence: 100.0% Identity: 58% PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: the crystal structure of xc847 from xanthomonas campestris: a 3-52 oligoribonuclease of dnaq fold family with a novel opposingly-shifted3 helix Phyre2 PDB 2qxf chain A domain 1 Region: 5 - 181 Aligned: 165 Modelled: 177 Confidence: 100.0% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 1y97 chain A domain 1 Region: 2 - 181 Aligned: 173 Modelled: 180 Confidence: 100.0% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 3b6o chain A domain 1 Region: 6 - 180 Aligned: 168 Modelled: 175 Confidence: 100.0% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 3u6f chain A Region: 6 - 180 Aligned: 166 Modelled: 175 Confidence: 100.0% Identity: 14% PDB header:hydrolase/dna Chain: A: PDB Molecule:three prime repair exonuclease 1; PDBTitle: mouse trex1 d200n mutant Phyre2 PDB 2p1j chain B Region: 8 - 180 Aligned: 158 Modelled: 173 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:dna polymerase iii polc-type; PDBTitle: crystal structure of a polc-type dna polymerase iii2 exonuclease domain from thermotoga maritima Phyre2 PDB 1w0h chain A Region: 6 - 181 Aligned: 171 Modelled: 176 Confidence: 100.0% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 3cm6 chain A Region: 6 - 177 Aligned: 167 Modelled: 172 Confidence: 100.0% Identity: 17% PDB header:hydrolase, apoptosis Chain: A: PDB Molecule:cell death-related nuclease 4; PDBTitle: crystal structure of cell-death related nuclease 4 (crn-4)2 bound with er Phyre2 PDB 2xri chain A Region: 1 - 177 Aligned: 172 Modelled: 177 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:eri1 exoribonuclease 3; PDBTitle: crystal structure of human eri1 exoribonuclease 3 Phyre2 PDB 2f96 chain A domain 1 Region: 8 - 178 Aligned: 166 Modelled: 171 Confidence: 100.0% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 2gui chain A domain 1 Region: 7 - 175 Aligned: 155 Modelled: 169 Confidence: 100.0% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 1zbh chain A Region: 6 - 176 Aligned: 166 Modelled: 166 Confidence: 100.0% Identity: 11% PDB header:hydrolase/rna Chain: A: PDB Molecule:3'-5' exonuclease eri1; PDBTitle: 3'-end specific recognition of histone mrna stem-loop by 3'-2 exonuclease Phyre2 PDB 1zbu chain B Region: 6 - 181 Aligned: 171 Modelled: 176 Confidence: 100.0% Identity: 12% PDB header:hydrolase Chain: B: PDB Molecule:3'-5' exonuclease eri1; PDBTitle: crystal structure of full-length 3'-exonuclease Phyre2 PDB 1wlj chain A Region: 7 - 180 Aligned: 156 Modelled: 174 Confidence: 99.9% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 2is3 chain B Region: 3 - 178 Aligned: 145 Modelled: 152 Confidence: 99.9% Identity: 11% PDB header:hydrolase Chain: B: PDB Molecule:ribonuclease t; PDBTitle: crystal structure of escherichia coli rnase t Phyre2 PDB 1uoc chain A Region: 3 - 180 Aligned: 173 Modelled: 178 Confidence: 99.2% Identity: 12% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: CAF1-like ribonuclease Phyre2 PDB 2d5r chain A domain 1 Region: 7 - 179 Aligned: 168 Modelled: 173 Confidence: 99.0% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: CAF1-like ribonuclease Phyre2 1 d2igia1 2 d1j9aa_ 3 c3tr8A_ 4 c2gbzA_ 5 d2qxfa1 6 d1y97a1 7 d3b6oa1 8 c3u6fA_ 9 c2p1jB_ 10 d1w0ha_ 11 c3cm6A_ 12 c2xriA_ 13 d2f96a1 14 d2guia1 15 c1zbhA_ 16 c1zbuB_ 17 d1wlja_ 18 c2is3B_ 19 d1uoca_ 20 d2d5ra1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2igia1 100.0 100 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 2 d1j9aa_ 100.0 71 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 3 c3tr8A_ 100.0 59 PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: structure of an oligoribonuclease (orn) from coxiella burnetii 4 c2gbzA_ 100.0 58 PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: the crystal structure of xc847 from xanthomonas campestris: a 3-52 oligoribonuclease of dnaq fold family with a novel opposingly-shifted3 helix 5 d2qxfa1 100.0 17 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 6 d1y97a1 100.0 16 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 7 d3b6oa1 100.0 15 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 8 c3u6fA_ 100.0 14 PDB header:hydrolase/dna Chain: A: PDB Molecule:three prime repair exonuclease 1; PDBTitle: mouse trex1 d200n mutant 9 c2p1jB_ 100.0 23 PDB header:transferase Chain: B: PDB Molecule:dna polymerase iii polc-type; PDBTitle: crystal structure of a polc-type dna polymerase iii2 exonuclease domain from thermotoga maritima 10 d1w0ha_ 100.0 13 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 11 c3cm6A_ 100.0 17 PDB header:hydrolase, apoptosis Chain: A: PDB Molecule:cell death-related nuclease 4; PDBTitle: crystal structure of cell-death related nuclease 4 (crn-4)2 bound with er 12 c2xriA_ 100.0 13 PDB header:hydrolase Chain: A: PDB Molecule:eri1 exoribonuclease 3; PDBTitle: crystal structure of human eri1 exoribonuclease 3 13 d2f96a1 100.0 13 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 14 d2guia1 100.0 15 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 15 c1zbhA_ 100.0 11 PDB header:hydrolase/rna Chain: A: PDB Molecule:3'-5' exonuclease eri1; PDBTitle: 3'-end specific recognition of histone mrna stem-loop by 3'-2 exonuclease 16 c1zbuB_ 100.0 12 PDB header:hydrolase Chain: B: PDB Molecule:3'-5' exonuclease eri1; PDBTitle: crystal structure of full-length 3'-exonuclease 17 d1wlja_ 99.9 17 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 18 c2is3B_ 99.9 11 PDB header:hydrolase Chain: B: PDB Molecule:ribonuclease t; PDBTitle: crystal structure of escherichia coli rnase t 19 d1uoca_ 99.2 12 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:CAF1-like ribonuclease 20 d2d5ra1 99.0 17 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:CAF1-like ribonuclease 21 d1kfsa1 not modelled 99.0 15 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 22 c2kzzA_ not modelled 98.9 15 PDB header:transferase/dna Chain: A: PDB Molecule:protein (dna polymerase i); PDBTitle: klenow fragment with normal substrate and zinc only 23 d1x9ma1 not modelled 98.9 16 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 24 c2p51A_ not modelled 98.8 17 PDB header:hydrolase, gene regulation Chain: A: PDB Molecule:spcc18.06c protein; PDBTitle: crystal structure of the s. pombe pop2p deadenylation2 subunit 25 c1tk0A_ not modelled 98.7 16 PDB header:transferase/electron transport/dna Chain: A: PDB Molecule:dna polymerase; PDBTitle: t7 dna polymerase ternary complex with 8 oxo guanosine and2 ddctp at the insertion site 26 c2gv9B_ not modelled 98.4 22 PDB header:transferase Chain: B: PDB Molecule:dna polymerase; PDBTitle: crystal structure of the herpes simplex virus type 1 dna polymerase 27 c1njzA_ not modelled 98.3 10 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase i; PDBTitle: cytosine-thymine mismatch at the polymerase active site 28 d1wn7a1 not modelled 98.2 16 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 29 d1tgoa1 not modelled 98.2 16 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 30 c3iayA_ not modelled 98.1 21 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase delta catalytic subunit; PDBTitle: ternary complex of dna polymerase delta 31 c3d45B_ not modelled 98.1 17 PDB header:hydrolase Chain: B: PDB Molecule:poly(a)-specific ribonuclease parn; PDBTitle: crystal structure of mouse parn in complex with m7gpppg 32 c2a1sC_ not modelled 98.1 17 PDB header:hydrolase Chain: C: PDB Molecule:poly(a)-specific ribonuclease parn; PDBTitle: crystal structure of native parn nuclease domain 33 d1d5aa1 not modelled 98.0 14 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 34 d1qhta1 not modelled 98.0 13 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 35 d2hhva1 not modelled 98.0 14 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 36 c2vwkA_ not modelled 97.9 16 PDB header:dna replication Chain: A: PDB Molecule:dna polymerase; PDBTitle: uracil recognition in archaeal dna polymerases captured by2 x-ray crystallography. v93q polymerase variant 37 d1q8ia1 not modelled 97.6 14 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 38 d1ih7a1 not modelled 97.6 15 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 39 c1d5aA_ not modelled 97.5 16 PDB header:transferase Chain: A: PDB Molecule:protein (dna polymerase); PDBTitle: crystal structure of an archaebacterial dna polymerase2 d.tok. deposition of second native structure at 2.43 angstrom 40 d1s5ja1 not modelled 97.3 19 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 41 d1noya_ not modelled 97.3 14 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 42 c1s5jA_ not modelled 97.1 20 PDB header:transferase Chain: A: PDB Molecule:dna polymerase i; PDBTitle: insight in dna replication: the crystal structure of dna2 polymerase b1 from the archaeon sulfolobus solfataricus 43 c2dtuA_ not modelled 96.8 13 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase; PDBTitle: crystal structure of the beta hairpin loop deletion variant2 of rb69 gp43 in complex with dna containing an abasic site3 analog 44 d1yt3a3 not modelled 96.5 15 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 45 c1q8iA_ not modelled 96.5 14 PDB header:transferase Chain: A: PDB Molecule:dna polymerase ii; PDBTitle: crystal structure of escherichia coli dna polymerase ii 46 c1yt3A_ not modelled 95.5 13 PDB header:hydrolase,translation Chain: A: PDB Molecule:ribonuclease d; PDBTitle: crystal structure of escherichia coli rnase d, an2 exoribonuclease involved in structured rna processing 47 c2e6mA_ not modelled 95.5 14 PDB header:hydrolase Chain: A: PDB Molecule:werner syndrome atp-dependent helicase homolog; PDBTitle: structure of mouse werner exonuclease domain 48 c4ktqA_ not modelled 95.4 13 PDB header:transferase/dna Chain: A: PDB Molecule:protein (large fragment of dna polymerase i); PDBTitle: binary complex of the large fragment of dna polymerase i2 from t. aquaticus bound to a primer/template dna 49 d2py5a1 not modelled 94.7 12 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 50 c2ex3I_ not modelled 93.6 13 PDB header:transferase/replication Chain: I: PDB Molecule:dna polymerase; PDBTitle: bacteriophage phi29 dna polymerase bound to terminal protein 51 d2hbka2 not modelled 93.2 17 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 52 c3cymA_ not modelled 87.9 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein bad_0989; PDBTitle: crystal structure of protein bad_0989 from bifidobacterium2 adolescentis 53 c3ikmD_ not modelled 83.3 21 PDB header:transferase Chain: D: PDB Molecule:dna polymerase subunit gamma-1; PDBTitle: crystal structure of human mitochondrial dna polymerase2 holoenzyme 54 c2hbkA_ not modelled 79.8 17 PDB header:hydrolase, gene regulation Chain: A: PDB Molecule:exosome complex exonuclease rrp6; PDBTitle: structure of the yeast nuclear exosome component, rrp6p,2 reveals an interplay between the active site and the hrdc3 domain; protein in complex with mn 55 d1vk0a_ not modelled 65.3 19 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:DnaQ-like 3'-5' exonuclease 56 c3sahA_ not modelled 61.3 18 PDB header:hydrolase Chain: A: PDB Molecule:exosome component 10; PDBTitle: crystal structure of the human rrp6 catalytic domain with y436a2 mutation in the catalytic site 57 d2bgxa1 not modelled 19.0 14 Fold:PGBD-like Superfamily:PGBD-like Family:Peptidoglycan binding domain, PGBD 58 c2d3wB_ not modelled 10.6 35 PDB header:biosynthetic protein Chain: B: PDB Molecule:probable atp-dependent transporter sufc; PDBTitle: crystal structure of escherichia coli sufc, an atpase2 compenent of the suf iron-sulfur cluster assembly machinery 59 d1tf5a1 not modelled 8.0 23 Fold:Pre-protein crosslinking domain of SecA Superfamily:Pre-protein crosslinking domain of SecA Family:Pre-protein crosslinking domain of SecA 60 c3efgA_ not modelled 7.0 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:protein slyx homolog; PDBTitle: structure of slyx protein from xanthomonas campestris pv. campestris2 str. atcc 33913 61 c2v5iA_ not modelled 6.7 20 PDB header:viral protein Chain: A: PDB Molecule:salmonella typhimurium db7155 bacteriophage det7 PDBTitle: structure of the receptor-binding protein of bacteriophage2 det7: a podoviral tailspike in a myovirus 62 c3l6sA_ not modelled 5.6 16 PDB header:hydrolase Chain: A: PDB Molecule:aspartyl aminopeptidase; PDBTitle: crystal structure of human aspartyl aminopeptidase (dnpep),2 in complex with aspartic acid hydroxamate 63 c3mesB_ not modelled 5.2 29 PDB header:transferase Chain: B: PDB Molecule:choline kinase; PDBTitle: crystal structure of choline kinase from cryptosporidium2 parvum iowa ii, cgd3_2030

Binding site prediction

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0