PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3sahA_

Fold library id	PDB Header	Molecule	Title
c3sahA_	PDB header: hydrolase	Chain: A: PDB Molecule: exosome component 10;	PDBTitle: crystal structure of the human rrp6 catalytic domain with y436a2 mutation in the catalytic site

Links to external resources
Added to library: Sat Jul 9 09:32:10 2011

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence S I I R P Q L K F R E K I D N S N T P F L P K I F I K P N A Q K P L P Q A L S K E R R Q D M F A H P Y Q Y E L N H F T P A D A V L Q K P Q P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T T T
S S
S S S
S
T T
S S
G G G S S S
T T S
T T T
S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence Q L Y R P I E E T P C H F I S S L D E L V E L N E K L L N C Q E F A V D L E H H S Y R S F L G L T C L M Q I S T R T E D F I I D T L E L R S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G S
S T
S
T T
S S
S S
T T T T G G

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence D M Y I L N E S L T D P A I V K V F H G A D S D I E W L Q K D F G L Y V V N M F D T H Q A A R L L N H S L D H L L K L Y C N V D S N K Q Y Q

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G G G T
T T S S S
T
S S
T S
G G G G

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence L A D W R I R P L P E E M L S A A R D D T H Y L L Y I Y D K M R L E M W E R G N G Q P V Q L Q V V W Q R S R D I C L K K F I K P I F T D E S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S
S T T T T S S S T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence Y L E L Y R K Q K K H L N T Q Q L T A F Q L L F A W R D K T A R R E D E S Y G Y V L P N H M M L K I A E E L P K E P Q G I I A C C N P V P P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T
S S T T S S S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . .

Sequence L V R Q Q I N E M H L L I Q Q A R E M P L L K S E V A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
T T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	S	I	I	R	P	Q	L	K	F	R	E	K	I	D	N	S	N	T	P	F	L	P	K	I	F	I	K	P	N	A	Q	K	P	L	P	Q	A	L	S	K	E	R	R	Q	D	M	F	A	H	P	Y	Q	Y	E	L	N	H	F	T	P	A	D	A	V	L	Q	K	P	Q	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T	T	T	T		S	S					S	S	S								S		T	T		S	S				G	G	G	S	S	S					T	T	S		T	T						T									S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	Q	L	Y	R	P	I	E	E	T	P	C	H	F	I	S	S	L	D	E	L	V	E	L	N	E	K	L	L	N	C	Q	E	F	A	V	D	L	E	H	H	S	Y	R	S	F	L	G	L	T	C	L	M	Q	I	S	T	R	T	E	D	F	I	I	D	T	L	E	L	R	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						G	G	G	S							S													T		S											T	T		S	S											S	S							T	T	T	T	G	G
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	D	M	Y	I	L	N	E	S	L	T	D	P	A	I	V	K	V	F	H	G	A	D	S	D	I	E	W	L	Q	K	D	F	G	L	Y	V	V	N	M	F	D	T	H	Q	A	A	R	L	L	N	H	S	L	D	H	L	L	K	L	Y	C	N	V	D	S	N	K	Q	Y	Q
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G	G	G					T		T	T	S					S	S												T					S	S														T									S					G	G	G	G
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	L	A	D	W	R	I	R	P	L	P	E	E	M	L	S	A	A	R	D	D	T	H	Y	L	L	Y	I	Y	D	K	M	R	L	E	M	W	E	R	G	N	G	Q	P	V	Q	L	Q	V	V	W	Q	R	S	R	D	I	C	L	K	K	F	I	K	P	I	F	T	D	E	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T		S	S															S														T	T	T	T	S	S	S															T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	Y	L	E	L	Y	R	K	Q	K	K	H	L	N	T	Q	Q	L	T	A	F	Q	L	L	F	A	W	R	D	K	T	A	R	R	E	D	E	S	Y	G	Y	V	L	P	N	H	M	M	L	K	I	A	E	E	L	P	K	E	P	Q	G	I	I	A	C	C	N	P	V	P	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T																										T																					S	S						T	T	S	S	S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.
Sequence	L	V	R	Q	Q	I	N	E	M	H	L	L	I	Q	Q	A	R	E	M	P	L	L	K	S	E	V	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					T													T	S				T	T	T