Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9Z0R6
DateWed Jul 10 14:14:37 BST 2013
Unique Job IDb50ef405e1b95f7f
SequenceMMAQFPTAMN ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:67.393 Y:65.010 Z:69.667
Model (left) based on template c2dx1A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
Confidence and coverage
Confidence:100.0% Coverage: 22%
366 residues ( 22% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
788 residues ( 47%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MMAQFPTAMNGGPNMWAITSEERTKHDKQFDNLKPSGGYITGDQARTFFLQSGLPAPVLA
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   .........70.........80.........90.........100.........110.........120
Sequence  EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
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   .........130.........140.........150.........160.........170.........180
Sequence  SMPNLSIHQPLPPVAPIATPLSSATSGTSIPPLMMPAPLVPSVSTSSLPNGTASLIQPLS
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   .........190.........200.........210.........220.........230.........240
Sequence  IPYSSSTLPHASSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWA
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   .........250.........260.........270.........280.........290.........300
Sequence  VPQPSRLKYRQKFNSLDKGMSGYLSGFQARNALLQSNLSQTQLATIWTLADIDGDGQLKA
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   .........310.........320.........330.........340.........350.........360
Sequence  EEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQVDSVNGTLPSYQKTQEEEPQKKL
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   .........370.........380.........390.........400.........410.........420
Sequence  PVTFEDKRKANYERGNMELEKRRQVLMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQ
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   .........430.........440.........450.........460.........470.........480
Sequence  LELEKRLEKQRELERQREEERRKEIERREAAKQELERQRRLEWERLRRQELLSQKTREQE
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   .........490.........500.........510.........520.........530.........540
Sequence  DIVRLSSRKKSLHLELEAVNGKHQQISGRLQDVQIRKQTQKTELEVLDKQCDLEIMEIKQ
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   .........550.........560.........570.........580.........590.........600
Sequence  LQQELKEYQNKLIYLVPEKQLLNERIKNMQLSNTPDSGISLLHKKSSEKEELCQRLKEQL
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   .........610.........620.........630.........640.........650.........660
Sequence  DALEKETASKLSEMDSFNNQLKELRESYNTQQLALEQLHKIKRDKLKEIERKRLEQIQKK
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   .........670.........680.........690.........700.........710.........720
Sequence  KLEDEAARKAKQGKENLWRESIRKEEEEKQKRLQEEKSQDKTQEEERKAEAKQSETASAL
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   .........730.........740.........750.........760.........770.........780
Sequence  VNYRALYPFEARNHDEMSFSSGDIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEKVLSS
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   .........790.........800.........810.........820.........830.........840
Sequence  EKALSPKKALLPPTVSLSATSTSSQPPASVTDYHNVSFSNLTVNTTWQQKSAFTRTVSPG
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   .........850.........860.........870.........880.........890.........900
Sequence  SVSPIHGQGQAVENLKAQALCSWTAKKENHLNFSKHDVITVLEQQENWWFGEVHGGRGWF
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   .........910.........920.........930.........940.........950.........960
Sequence  PKSYVKLIPGNEVQRGEPEALYAAVTKKPTSTAYPVTSTAYPVGEDYIALYSYSSVEPGD
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   .........970.........980.........990.........1000.........1010.........1020
Sequence  LTFTEGEEILVTQKDGEWWTGSIGERTGIFPSNYVRPKDQENFGNASKSGASNKKPEIAQ
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   .........1030.........1040.........1050.........1060.........1070.........1080
Sequence  VTSAYAASGTEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSS
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   .........1090.........1100.........1110.........1120.........1130.........1140
Sequence  ERTMPTFHAVCQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQGETNGLTGLFPSN
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   .........1150.........1160.........1170.........1180.........1190.........1200
Sequence  YVKMTTDSDPSQQWCADLQALDTMQPTERKRQGYIHELIQTEERYMDDDLQLVIEVFQKR
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   .........1210.........1220.........1230.........1240.........1250.........1260
Sequence  MAEEGFLTEADMALIFVNWKELIMSNTKLLRALRVRKKTGGEKMPVQMIGDILAAELSHM
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   .........1270.........1280.........1290.........1300.........1310.........1320
Sequence  QAYIRFCSCQLNGATLLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYP
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   .........1330.........1340.........1350.........1360.........1370.........1380
Sequence  LLIRSILENTPQSHVDHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLA
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   .........1390.........1400.........1410.........1420.........1430.........1440
Sequence  EQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHAFLFNDFLLLTYLVRQFAAASGHEKLF
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   .........1450.........1460.........1470.........1480.........1490.........1500
Sequence  NSKSSAQFRMYKTPIFLNEVLVKLPTDPSGDEPVFHISHIDRVYTLRTDNINERTAWVQK
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   .........1510.........1520.........1530.........1540.........1550.........1560
Sequence  IKGASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEVSM
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   .........1570.........1580.........1590.........1600.........1610.........1620
Sequence  GSQSYTTRTLQDTLNPKWNFNCQFFIKDLYQDVLCLTMFDRDQFSPDDFLGRTEVPVAKI
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   .........1630.........1640.........1650.........
Sequence  RTEQESKGPTTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
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Confidence Key
High(9)                    Low (0)
?Disordered ( 44%)
Alpha helix ( 40%)
Beta strand ( 10%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2dx1 chain A

3D model

Region: 1092 - 1508
Aligned: 366
Modelled: 402
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 3jv3 chain A

3D model

Region: 1089 - 1367
Aligned: 278
Modelled: 279
Confidence: 100.0%
Identity: 76%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l

Phyre2

PDB 3odo chain A

3D model

Region: 1148 - 1505
Aligned: 354
Modelled: 356
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef

Phyre2

PDB 3ky9 chain B

3D model

Region: 1169 - 1519
Aligned: 315
Modelled: 333
Confidence: 100.0%
Identity: 22%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 1xcg chain A

3D model

Region: 1150 - 1507
Aligned: 340
Modelled: 344
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef

Phyre2

PDB 1ki1 chain B

3D model

Region: 1162 - 1516
Aligned: 342
Modelled: 355
Confidence: 100.0%
Identity: 77%
PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42

Phyre2

PDB 1x86 chain A

3D model

Region: 1149 - 1511
Aligned: 348
Modelled: 363
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa

Phyre2

PDB 3ksy chain A

3D model

Region: 1171 - 1507
Aligned: 319
Modelled: 337
Confidence: 100.0%
Identity: 16%
PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)

Phyre2

PDB 3t06 chain E

3D model

Region: 1150 - 1506
Aligned: 342
Modelled: 357
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa

Phyre2

PDB 1xdv chain B

3D model

Region: 1172 - 1507
Aligned: 314
Modelled: 316
Confidence: 100.0%
Identity: 15%
PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.

Phyre2

PDB 2dfk chain A

3D model

Region: 1162 - 1526
Aligned: 338
Modelled: 350
Confidence: 100.0%
Identity: 20%
PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex

Phyre2

PDB 2vrw chain B

3D model

Region: 1167 - 1556
Aligned: 352
Modelled: 372
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor

Phyre2

PDB 1foe chain A

3D model

Region: 1167 - 1512
Aligned: 337
Modelled: 346
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1

Phyre2

PDB 4gou chain A

3D model

Region: 1162 - 1504
Aligned: 322
Modelled: 343
Confidence: 100.0%
Identity: 13%
PDB header:signaling protein
Chain: A: PDB Molecule:ehrgs-rhogef;
PDBTitle: crystal structure of an rgs-rhogef from entamoeba histolytica

Phyre2

PDB 2z0q chain A

3D model

Region: 1162 - 1506
Aligned: 304
Modelled: 331
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)

Phyre2

PDB 3odx chain A

3D model

Region: 1166 - 1508
Aligned: 326
Modelled: 330
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef

Phyre2

PDB 3bji chain A

3D model

Region: 1167 - 1519
Aligned: 317
Modelled: 335
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1

Phyre2

PDB 3odw chain B

3D model

Region: 1166 - 1509
Aligned: 322
Modelled: 329
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef

Phyre2

PDB 4gzu chain B

3D model

Region: 1170 - 1505
Aligned: 293
Modelled: 321
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: B: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp2

Phyre2

PDB 1dbh chain A

3D model

Region: 1168 - 1507
Aligned: 330
Modelled: 340
Confidence: 100.0%
Identity: 15%
PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1

Phyre2

PDB 2khn chain A

3D model

Region: 2 - 112
Aligned: 111
Modelled: 111
Confidence: 99.9%
Identity: 69%
PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.

Phyre2

PDB 3fia chain A

3D model

Region: 7 - 104
Aligned: 98
Modelled: 94
Confidence: 99.9%
Identity: 68%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.

Phyre2

PDB 1gri chain A

3D model

Region: 947 - 1148
Aligned: 198
Modelled: 198
Confidence: 99.7%
Identity: 23%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 3jzy chain A

3D model

Region: 1530 - 1653
Aligned: 124
Modelled: 124
Confidence: 99.6%
Identity: 96%
PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain

Phyre2

PDB 2lqn chain A

3D model

Region: 920 - 1153
Aligned: 200
Modelled: 200
Confidence: 99.6%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2eyz chain A

3D model

Region: 927 - 1155
Aligned: 186
Modelled: 186
Confidence: 99.6%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2l3s chain A

3D model

Region: 945 - 1147
Aligned: 160
Modelled: 160
Confidence: 99.5%
Identity: 21%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2
1

c2dx1A_
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c3jv3A_
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c3odoA_
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c3ky9B_
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c1xcgA_
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c1ki1B_
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c1x86A_
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c3ksyA_
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c3t06E_
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c1xdvB_
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c2dfkA_
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c2vrwB_
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c1foeA_
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c4gouA_
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c2z0qA_
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c3odxA_
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c3bjiA_
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c3odwB_
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c4gzuB_
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c1dbhA_
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c2khnA_
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c3fiaA_
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c1griA_
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c3jzyA_
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c2lqnA_
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c2eyzA_
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c2l3sA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2dx1A_



100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
2c3jv3A_



100.0 76 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l
3c3odoA_



100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef
4c3ky9B_



100.0 22 PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
5c1xcgA_



100.0 26 PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef
6c1ki1B_



100.0 77 PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42
7c1x86A_



100.0 26 PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa
8c3ksyA_



100.0 16 PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)
9c3t06E_



100.0 26 PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa
10c1xdvB_



100.0 15 PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.
11c2dfkA_



100.0 20 PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex
12c2vrwB_



100.0 23 PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor
13c1foeA_



100.0 22 PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1
14c4gouA_



100.0 13 PDB header:signaling protein
Chain: A: PDB Molecule:ehrgs-rhogef;
PDBTitle: crystal structure of an rgs-rhogef from entamoeba histolytica
15c2z0qA_



100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)
16c3odxA_



100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef
17c3bjiA_



100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1
18c3odwB_



100.0 27 PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef
19c4gzuB_



100.0 24 PDB header:signaling protein
Chain: B: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp2
20c1dbhA_



100.0 15 PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1
21c4h6yA_



not modelled 100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 1;
PDBTitle: crystal strucure of the dh-ph-ph domain of farp1
22c2rgnB_



not modelled 100.0 20 PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa
23c3mpxA_



not modelled 100.0 20 PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5
24c1lb1C_



not modelled 100.0 20 PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa
25c1ntyA_



not modelled 100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:triple functional domain protein;
PDBTitle: crystal structure of the first dh/ph domain of trio to 1.7 a
26d1xcga1



not modelled 100.0 28 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
27d1txda1



not modelled 100.0 28 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
28d1ki1b1



not modelled 100.0 77 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
29c4gyvA_



not modelled 100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:ferm, rhogef and pleckstrin domain-containing protein 2;
PDBTitle: crystal strucure of the dh domain of farp2
30d1dbha1



not modelled 100.0 16 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
31d2dfka1



not modelled 100.0 22 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
32c3eo2A_



not modelled 100.0 30 PDB header:splicing
Chain: A: PDB Molecule:neuroepithelial cell-transforming gene 1 protein;
PDBTitle: crystal structure of the rhogef domain of human neuroepithelial cell-2 transforming gene 1 protein
33d1foea1



not modelled 100.0 26 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
34c3gf9A_



not modelled 100.0 94 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 rhogef domain
35d1f5xa_



not modelled 99.9 27 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
36d1by1a_



not modelled 99.9 20 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
37d1kz7a1



not modelled 99.9 23 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
38d1ntya1



not modelled 99.9 24 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
39c2khnA_



99.9 69 PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.
40c3fiaA_



99.9 68 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.
41c2jq6A_



not modelled 99.9 38 PDB header:metal binding protein
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of eh-domain of ehd1
42c2kfhA_



not modelled 99.8 39 PDB header:protein binding
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of the c-terminal domain of ehd1 with fnyestgpftak
43d2jxca1



not modelled 99.8 38 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
44c2kgrA_



not modelled 99.8 38 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: solution structure of protein itsn1 from homo sapiens.2 northeast structural genomics consortium target hr5524a
45d1iq3a_



not modelled 99.7 35 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
46d1fi6a_



not modelled 99.7 39 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
47d1c07a_



not modelled 99.7 37 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
48c2qptA_



not modelled 99.7 38 PDB header:endocytosis
Chain: A: PDB Molecule:eh domain-containing protein-2;
PDBTitle: crystal structure of an ehd atpase involved in membrane remodelling
49c1griA_



99.7 23 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
50c2lg1A_



not modelled 99.7 19 PDB header:metal binding protein
Chain: A: PDB Molecule:a-kinase anchor protein 13;
PDBTitle: solution structure of the human akap13 ph domain and stabilizing dh2 helix
51c3jzyA_



99.6 96 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain
52d1qjta_



not modelled 99.6 26 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
53d1ki1b2



not modelled 99.6 73 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
54c2lqnA_



99.6 21 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
55c2eyzA_



99.6 21 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
56c2l3sA_



99.5 21 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
57c2fk9A_



not modelled 99.5 25 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta
58c1ng2A_



not modelled 99.4 23 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
59c1ov3A_



not modelled 99.4 23 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
60d2nq3a1



not modelled 99.4 23 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
61c2nq3A_



not modelled 99.4 23 PDB header:ligase
Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase;
PDBTitle: crystal structure of the c2 domain of human itchy homolog2 e3 ubiquitin protein ligase
62c1mv3A_



not modelled 99.4 18 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
63d1xcga2



not modelled 99.3 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
64d1gmia_



not modelled 99.3 23 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
65d2dfka2



not modelled 99.3 20 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
66d1zc3b1



not modelled 99.2 18 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
67c3nsjA_



not modelled 99.2 23 PDB header:immune system
Chain: A: PDB Molecule:perforin-1;
PDBTitle: the x-ray crystal structure of lymphocyte perforin
68d1udla_



not modelled 99.2 85 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
69c3kwtA_



not modelled 99.2 25 PDB header:metal binding protein
Chain: A: PDB Molecule:munc13-1;
PDBTitle: munc13-1 c2b-domain, calcium-free
70d1bdya_



not modelled 99.2 18 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
71d1dbha2



not modelled 99.2 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
72c2dmhA_



not modelled 99.2 22 PDB header:lipid binding protein
Chain: A: PDB Molecule:myoferlin;
PDBTitle: solution structure of the first c2 domain of human myoferlin
73d2ep6a1



not modelled 99.2 36 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
74d1wfja_



not modelled 99.2 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
75d1txda2



not modelled 99.1 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
76c3l9bA_



not modelled 99.1 17 PDB header:membrane protein
Chain: A: PDB Molecule:otoferlin;
PDBTitle: crystal structure of rat otoferlin c2a
77d2cjsa1



not modelled 99.1 22 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
78c3m7fB_



not modelled 99.1 31 PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex
79d1rlwa_



not modelled 99.1 20 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
80d1ng2a2



not modelled 99.1 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
81c2jqzA_



not modelled 99.0 25 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf2;
PDBTitle: solution structure of the c2 domain of human smurf2
82c3qwmA_



not modelled 99.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:iq motif and sec7 domain-containing protein 1;
PDBTitle: crystal structure of gep100, the plextrin homology domain of iq motif2 and sec7 domain-containing protein 1 isoform a
83c1dqvA_



not modelled 99.0 24 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin iii;
PDBTitle: crystal structure of synaptotagmin iii c2a/c2b
84c2enjA_



not modelled 99.0 18 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c theta type;
PDBTitle: solution sturcture of the c2 domain from human protein2 kinase c theta
85d1qasa2



not modelled 99.0 25 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
86d1dsya_



not modelled 99.0 30 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
87c2rqrA_



not modelled 99.0 13 PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex
88c3nmzD_



not modelled 99.0 29 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
89c1x2qA_



not modelled 99.0 30 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
90c2ysqA_



not modelled 98.9 20 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9;
PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9
91c2cubA_



not modelled 98.9 33 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
92c2jxbA_



not modelled 98.9 25 PDB header:signaling protein complex
Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain,
PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
93c2eyyA_



not modelled 98.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
94c2ed0A_



not modelled 98.9 39 PDB header:signaling protein
Chain: A: PDB Molecule:abl interactor 2;
PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2)
95c2yuoA_



not modelled 98.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
96d1ov3a2



not modelled 98.9 27 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
97c2ekhA_



not modelled 98.9 20 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structures of the sh3 domain of human kiaa0418
98c2yunA_



not modelled 98.9 27 PDB header:protein transport
Chain: A: PDB Molecule:nostrin;
PDBTitle: solution structure of the sh3 domain of human nostrin
99c2r83B_



not modelled 98.9 26 PDB header:endocytosis, exocytosis
Chain: B: PDB Molecule:synaptotagmin-1;
PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b
100c2dlpA_



not modelled 98.9 28 PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
101c2dilA_



not modelled 98.9 29 PDB header:cell adhesion
Chain: A: PDB Molecule:proline-serine-threonine phosphatase-interacting
PDBTitle: solution structure of the sh3 domain of the human proline-2 serine-threonine phosphatase-interacting protein 1
102c2epdA_



not modelled 98.9 26 PDB header:protein binding
Chain: A: PDB Molecule:rho gtpase-activating protein 4;
PDBTitle: solution structure of sh3 domain in rho-gtpase-activating2 protein 4
103c2l0aA_



not modelled 98.9 44 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 1;
PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e
104c2nsqA_



not modelled 98.9 28 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein;
PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein
105c2csqA_



not modelled 98.9 30 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:rim binding protein 2;
PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2
106d1kz7a2



not modelled 98.9 19 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
107c2d8kA_



not modelled 98.9 28 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin vii;
PDBTitle: solution structure of the first c2 domain of synaptotagmin2 vii
108c2nwmA_



not modelled 98.9 29 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin
109c2dl8A_



not modelled 98.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:slit-robo rho gtpase-activating protein 2;
PDBTitle: solution structure of the sh3 domain of human slit-robo rho2 gtpase-activating protein 2
110c2dnuA_



not modelled 98.9 28 PDB header:structural genomics, structural protein
Chain: A: PDB Molecule:sh3 multiple domains 1;
PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human
111c3qwyA_



not modelled 98.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
112d1k4us_



not modelled 98.8 33 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
113c2ebpA_



not modelled 98.8 22 PDB header:cell adhesion
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1
114c3qwxX_



not modelled 98.8 26 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
115c2kymA_



not modelled 98.8 27 PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide
116c1x69A_



not modelled 98.8 32 PDB header:signaling protein
Chain: A: PDB Molecule:cortactin isoform a;
PDBTitle: solution structures of the sh3 domain of human src2 substrate cortactin
117c2ed1A_



not modelled 98.8 35 PDB header:signaling protein
Chain: A: PDB Molecule:130 kda phosphatidylinositol 4,5-biphosphate-
PDBTitle: solution structure of the sh3 domain of 130 kda2 phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase-3 activating protein
118c4glmD_



not modelled 98.8 30 PDB header:signaling protein
Chain: D: PDB Molecule:dynamin-binding protein;
PDBTitle: crystal structure of the sh3 domain of dnmbp protein [homo sapiens]
119c2dbkA_



not modelled 98.8 20 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structures of the sh3 domain of human crk-like2 protein
120c2df6A_



not modelled 98.8 45 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7;
PDBTitle: crystal structure of the sh3 domain of betapix in complex2 with a high affinity peptide from pak2

Binding site prediction 

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite