Phyre 2 Results for Q9VX18

Email	l.a.kelley@imperial.ac.uk
Description	Q9VX18
Date	Tue Jan 22 11:47:38 GMT 2013
Unique Job ID	7a130f8e795f6e0d

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2izvA_

Top template information

PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution

Confidence and coverage

Confidence:

100.0%

Coverage:

15%

152 residues ( 15% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Warning: 60% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M D S S I K L K D S N S N C S S N S N G N V G G G G V A G G G G S G S G G V C V S S I C S S D S F S I M P P P H H E L V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence S A N S I E L N A A A S L S D D S G V P L T T N S S I S S G D S Y R L G M C K F E I E M V E S D G E V S Q F D S L D N C

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence S E G G M S A E N F N T L K K G P L A P I D P P P E F Q D S P Q T T L V R S I S K N I V N S L R R W T S S Q S S F E H L

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ?
?
?
?
?
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence K D D A T T M V S G L A T A V L P E E P H P P S Q E L V L L L A K T E C K L D A L D G Q A L G Q M S L K E S Y A I N K H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence L Y S S D S I L N S H T D N I Y D E P N N I V S S S L G N S V D L L D E E Q S D A S S C S P L P S P P P P V S I V K I K

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence Q T L C P Y Y Q D H T R Y F K A I P T E Q D N I A S A K A A A A Q Q R F N S A G L S E I H D Y D L Y Y G A R R Q P V D N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence S S L Q R R Q A S L Y S P L G H T S H C H Y H H S H G H G H G S H H H H H H H Q P G Y G Y S H G Q R P N S R N S L N S R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence L S S S H N S L N V S S A N K P D D S I F I T Q A M S H D A L F T R E I S D F Y N V P I D S D I Y A F P V D M I E Q Q Q

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence Q Q Q L L V E E Q Q Q Q K P A A P T Y H K A S R R N K R N K R K Q R Y A G S G T G A G T E T S D G D G E K S K H G K Y R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence T P V G V G M G Q V S E S E P L H M T L D E V K Q F Y H T L Y S D A G K P T P K P M V K S S N E T I W S V S T N T T T T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence T A R T R S S V G T T R G G G G P P G A G N G A G G A S S D G G V G G G S A G G G G G K Y L S K Q N K H N L D N D K L N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence N N N N N N N N H Q P S Q Q Q L E K P P T E H H N Q H Q P P N N K H V L H S E K K S Q F T L N L K Q R F C S I F R F R R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence S N H S R C R G S G N N Q T G T F A S A N A N A A A T A P L I P P I A V I T S A P G A A G Q T Q L A S E L N G T L I T A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence E A D E P N A D L R K K F Q S R A L P P L P K K A A A Y A I E A V K S E P E E V K T N A I Q E P R A L Q F T S S I E K V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence K D Y G W Y W G P L S S E A A E K V L S S E P D G S F I V R D S S D D H Y I F S L S F K L N N C V R H V R I E Q D Q G T

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence F S F G S Y A K F K S Q T I T E F I E K A V E H S R S G R Y L F F L H R R P E H G P M R V Q L T N P V S R F K H V Q S L

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . .

Sequence Q H M C R F V I L K A V I R K D L I Q T L P L P R R L L D Y L N Y K H C Y S E Q V E S D S S H S Q I S G D G T M

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2izv chain A

Region: 833 - 999
Aligned: 152
Modelled: 167
Confidence: 100.0%
Identity: 34%
PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution

Phyre2

PDB 2c9w chain A

Region: 833 - 996
Aligned: 142
Modelled: 147
Confidence: 100.0%
Identity: 35%
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Phyre2

PDB 2vif chain A

Region: 833 - 954
Aligned: 122
Modelled: 122
Confidence: 99.9%
Identity: 43%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 3hiz chain B

Region: 840 - 955
Aligned: 100
Modelled: 102
Confidence: 99.9%
Identity: 29%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2izv chain A domain 2

Region: 833 - 953
Aligned: 108
Modelled: 121
Confidence: 99.8%
Identity: 32%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2hmh chain A

Region: 834 - 953
Aligned: 112
Modelled: 120
Confidence: 99.8%
Identity: 29%
PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.

Phyre2

PDB 2c9w chain A domain 2

Region: 829 - 926
Aligned: 98
Modelled: 98
Confidence: 99.8%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2crh chain A

Region: 822 - 954
Aligned: 121
Modelled: 133
Confidence: 99.8%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 1fu6 chain A

Region: 836 - 954
Aligned: 106
Modelled: 119
Confidence: 99.8%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2el8 chain A

Region: 842 - 925
Aligned: 84
Modelled: 84
Confidence: 99.8%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain

Phyre2

PDB 1x6c chain A

Region: 839 - 942
Aligned: 102
Modelled: 104
Confidence: 99.8%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1

Phyre2

PDB 1mil chain A

Region: 838 - 953
Aligned: 101
Modelled: 116
Confidence: 99.8%
Identity: 22%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1jwo chain A

Region: 840 - 953
Aligned: 97
Modelled: 99
Confidence: 99.8%
Identity: 21%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2oq1 chain A domain 1

Region: 841 - 974
Aligned: 116
Modelled: 119
Confidence: 99.8%
Identity: 22%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1ka6 chain A

Region: 840 - 953
Aligned: 99
Modelled: 99
Confidence: 99.7%
Identity: 23%
PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py

Phyre2

PDB 2kk6 chain A

Region: 830 - 953
Aligned: 108
Modelled: 120
Confidence: 99.7%
Identity: 22%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d

Phyre2

PDB 1a81 chain E domain 1

Region: 840 - 958
Aligned: 102
Modelled: 104
Confidence: 99.7%
Identity: 24%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2dlz chain A

Region: 840 - 955
Aligned: 104
Modelled: 116
Confidence: 99.7%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 2shp chain A domain 2

Region: 841 - 953
Aligned: 102
Modelled: 113
Confidence: 99.7%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2lct chain A

Region: 837 - 952
Aligned: 103
Modelled: 116
Confidence: 99.7%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide