Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	E	Q	L	V	T	P	E	N	V	T	T	K	D	G	K	I	N	L	L	D	L	N	R	Q	Q	M	R	E	F	F	K	D	L	G	E	K	P	F	R	A	D	Q	V	M	K	W	M	Y	H	Y	C	C	D	N	F	D	E	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	D	I	N	K	V	L	R	G	K	L	K	E	V	A	E	I	R	A	P	E	V	V	E	E	Q	R	S	S	D	G	T	I	K	W	A	I	A	V	G	D	Q	R	V	E	T	V	Y	I	P	E	D	D	R	A	T	L	C	V	S
Secondary structure
SS confidence
Disorder			?	?																			?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	Q	V	G	C	A	L	E	C	K	F	C	S	T	A	Q	Q	G	F	N	R	N	L	R	V	S	E	I	I	G	Q	V	W	R	A	A	K	I	V	G	A	A	K	V	T	G	Q	R	P	I	T	N	V	V	M	M	G	M	G	E
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	L	L	N	L	N	N	V	V	P	A	M	E	I	M	L	D	D	F	G	F	G	L	S	K	R	R	V	T	L	S	T	S	G	V	V	P	A	L	D	K	L	G	D	M	I	D	V	A	L	A	I	S	L	H	A	P	N	D	E
Secondary structure
SS confidence
Disorder																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	R	D	E	I	V	P	I	N	K	K	Y	N	I	E	T	F	L	A	A	V	R	R	Y	L	E	K	S	N	A	N	Q	G	R	V	T	I	E	Y	V	M	L	D	H	V	N	D	G	T	E	H	A	H	Q	L	A	E	L	L	K
Secondary structure
SS confidence
Disorder																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	T	P	C	K	I	N	L	I	P	W	N	P	F	P	G	A	P	Y	G	R	S	S	N	S	R	I	D	R	F	S	K	V	L	M	S	Y	G	F	T	T	I	V	R	K	T	R	G	D	D	I	D	A	A	C	G	Q	L	A	G
Secondary structure
SS confidence
Disorder																																																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.
Sequence		D	V	I	D	R	T	K	R	T	L	R	K	R	M	Q	G	E	A	I	D	I	K	A	V
Secondary structure
SS confidence
Disorder					?	?	?							?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3rfa chain A Region: 17 - 349 Aligned: 333 Modelled: 333 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: A: PDB Molecule:ribosomal rna large subunit methyltransferase n; PDBTitle: x-ray structure of rlmn from escherichia coli in complex with s-2 adenosylmethionine Phyre2 PDB 2a5h chain C Region: 46 - 348 Aligned: 277 Modelled: 278 Confidence: 100.0% Identity: 17% PDB header:isomerase Chain: C: PDB Molecule:l-lysine 2,3-aminomutase; PDBTitle: 2.1 angstrom x-ray crystal structure of lysine-2,3-aminomutase from2 clostridium subterminale sb4, with michaelis analog (l-alpha-lysine3 external aldimine form of pyridoxal-5'-phosphate). Phyre2 PDB 2yx0 chain A Region: 61 - 347 Aligned: 271 Modelled: 287 Confidence: 99.9% Identity: 14% PDB header:metal binding protein Chain: A: PDB Molecule:radical sam enzyme; PDBTitle: crystal structure of p. horikoshii tyw1 Phyre2 PDB 3c8f chain A Region: 102 - 341 Aligned: 217 Modelled: 231 Confidence: 99.9% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate formate-lyase 1-activating enzyme; PDBTitle: 4fe-4s-pyruvate formate-lyase activating enzyme with2 partially disordered adomet Phyre2 PDB 3can chain A Region: 172 - 343 Aligned: 156 Modelled: 172 Confidence: 99.8% Identity: 19% PDB header:lyase activator Chain: A: PDB Molecule:pyruvate-formate lyase-activating enzyme; PDBTitle: crystal structure of a domain of pyruvate-formate lyase-activating2 enzyme from bacteroides vulgatus atcc 8482 Phyre2 PDB 1tv8 chain A Region: 116 - 334 Aligned: 197 Modelled: 218 Confidence: 99.8% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: MoCo biosynthesis proteins Phyre2 PDB 1r30 chain A Region: 111 - 335 Aligned: 199 Modelled: 225 Confidence: 99.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:biotin synthase; PDBTitle: the crystal structure of biotin synthase, an s-2 adenosylmethionine-dependent radical enzyme Phyre2 PDB 1r30 chain A Region: 111 - 335 Aligned: 199 Modelled: 215 Confidence: 99.7% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: Biotin synthase Phyre2 PDB 2z2u chain A Region: 123 - 347 Aligned: 197 Modelled: 223 Confidence: 99.7% Identity: 20% PDB header:metal binding protein Chain: A: PDB Molecule:upf0026 protein mj0257; PDBTitle: crystal structure of archaeal tyw1 Phyre2 PDB 3t7v chain A Region: 111 - 335 Aligned: 202 Modelled: 222 Confidence: 99.7% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:methylornithine synthase pylb; PDBTitle: crystal structure of methylornithine synthase (pylb) Phyre2 PDB 3cix chain A Region: 111 - 335 Aligned: 199 Modelled: 222 Confidence: 99.7% Identity: 14% PDB header:adomet binding protein Chain: A: PDB Molecule:fefe-hydrogenase maturase; PDBTitle: x-ray structure of the [fefe]-hydrogenase maturase hyde from2 thermotoga maritima in complex with thiocyanate Phyre2 PDB 2qgq chain F Region: 129 - 381 Aligned: 208 Modelled: 224 Confidence: 99.6% Identity: 12% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein tm_1862; PDBTitle: crystal structure of tm_1862 from thermotoga maritima.2 northeast structural genomics consortium target vr77 Phyre2 PDB 1olt chain A Region: 124 - 342 Aligned: 208 Modelled: 219 Confidence: 99.6% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: Oxygen-independent coproporphyrinogen III oxidase HemN Phyre2 PDB 3k1d chain A Region: 289 - 343 Aligned: 55 Modelled: 55 Confidence: 81.5% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:1,4-alpha-glucan-branching enzyme; PDBTitle: crystal structure of glycogen branching enzyme synonym: 1,4-alpha-d-2 glucan:1,4-alpha-d-glucan 6-glucosyl-transferase from mycobacterium3 tuberculosis h37rv Phyre2 PDB 1tz7 chain A domain 1 Region: 284 - 323 Aligned: 40 Modelled: 40 Confidence: 77.8% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Amylase, catalytic domain Phyre2 PDB 3fa4 chain D Region: 252 - 343 Aligned: 71 Modelled: 80 Confidence: 76.9% Identity: 24% PDB header:lyase Chain: D: PDB Molecule:2,3-dimethylmalate lyase; PDBTitle: crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate2 lyase superfamily member, triclinic crystal form Phyre2 PDB 1rvg chain A Region: 186 - 297 Aligned: 112 Modelled: 112 Confidence: 76.8% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class II FBP aldolase Phyre2 PDB 1x1n chain A domain 1 Region: 284 - 323 Aligned: 40 Modelled: 40 Confidence: 71.3% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Amylase, catalytic domain Phyre2 PDB 1esw chain A Region: 284 - 323 Aligned: 40 Modelled: 40 Confidence: 67.5% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Amylase, catalytic domain Phyre2 PDB 2zq0 chain B Region: 258 - 339 Aligned: 74 Modelled: 82 Confidence: 65.2% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:alpha-glucosidase (alpha-glucosidase susb); PDBTitle: crystal structure of susb complexed with acarbose Phyre2 1 c3rfaA_ 2 c2a5hC_ 3 c2yx0A_ 4 c3c8fA_ 5 c3canA_ 6 d1tv8a_ 7 c1r30A_ 8 d1r30a_ 9 c2z2uA_ 10 c3t7vA_ 11 c3cixA_ 12 c2qgqF_ 13 d1olta_ 14 c3k1dA_ 15 d1tz7a1 16 c3fa4D_ 17 d1rvga_ 18 d1x1na1 19 d1eswa_ 20 c2zq0B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3rfaA_ 100.0 100 PDB header:oxidoreductase Chain: A: PDB Molecule:ribosomal rna large subunit methyltransferase n; PDBTitle: x-ray structure of rlmn from escherichia coli in complex with s-2 adenosylmethionine 2 c2a5hC_ 100.0 17 PDB header:isomerase Chain: C: PDB Molecule:l-lysine 2,3-aminomutase; PDBTitle: 2.1 angstrom x-ray crystal structure of lysine-2,3-aminomutase from2 clostridium subterminale sb4, with michaelis analog (l-alpha-lysine3 external aldimine form of pyridoxal-5'-phosphate). 3 c2yx0A_ 99.9 14 PDB header:metal binding protein Chain: A: PDB Molecule:radical sam enzyme; PDBTitle: crystal structure of p. horikoshii tyw1 4 c3c8fA_ 99.9 20 PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate formate-lyase 1-activating enzyme; PDBTitle: 4fe-4s-pyruvate formate-lyase activating enzyme with2 partially disordered adomet 5 c3canA_ 99.8 19 PDB header:lyase activator Chain: A: PDB Molecule:pyruvate-formate lyase-activating enzyme; PDBTitle: crystal structure of a domain of pyruvate-formate lyase-activating2 enzyme from bacteroides vulgatus atcc 8482 6 d1tv8a_ 99.8 20 Fold:TIM beta/alpha-barrel Superfamily:Radical SAM enzymes Family:MoCo biosynthesis proteins 7 c1r30A_ 99.7 15 PDB header:transferase Chain: A: PDB Molecule:biotin synthase; PDBTitle: the crystal structure of biotin synthase, an s-2 adenosylmethionine-dependent radical enzyme 8 d1r30a_ 99.7 15 Fold:TIM beta/alpha-barrel Superfamily:Radical SAM enzymes Family:Biotin synthase 9 c2z2uA_ 99.7 20 PDB header:metal binding protein Chain: A: PDB Molecule:upf0026 protein mj0257; PDBTitle: crystal structure of archaeal tyw1 10 c3t7vA_ 99.7 18 PDB header:transferase Chain: A: PDB Molecule:methylornithine synthase pylb; PDBTitle: crystal structure of methylornithine synthase (pylb) 11 c3cixA_ 99.7 14 PDB header:adomet binding protein Chain: A: PDB Molecule:fefe-hydrogenase maturase; PDBTitle: x-ray structure of the [fefe]-hydrogenase maturase hyde from2 thermotoga maritima in complex with thiocyanate 12 c2qgqF_ 99.6 12 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein tm_1862; PDBTitle: crystal structure of tm_1862 from thermotoga maritima.2 northeast structural genomics consortium target vr77 13 d1olta_ 99.6 14 Fold:TIM beta/alpha-barrel Superfamily:Radical SAM enzymes Family:Oxygen-independent coproporphyrinogen III oxidase HemN 14 c3k1dA_ 81.5 27 PDB header:transferase Chain: A: PDB Molecule:1,4-alpha-glucan-branching enzyme; PDBTitle: crystal structure of glycogen branching enzyme synonym: 1,4-alpha-d-2 glucan:1,4-alpha-d-glucan 6-glucosyl-transferase from mycobacterium3 tuberculosis h37rv 15 d1tz7a1 77.8 25 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 16 c3fa4D_ 76.9 24 PDB header:lyase Chain: D: PDB Molecule:2,3-dimethylmalate lyase; PDBTitle: crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate2 lyase superfamily member, triclinic crystal form 17 d1rvga_ 76.8 20 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class II FBP aldolase 18 d1x1na1 71.3 23 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 19 d1eswa_ 67.5 23 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 20 c2zq0B_ 65.2 19 PDB header:hydrolase Chain: B: PDB Molecule:alpha-glucosidase (alpha-glucosidase susb); PDBTitle: crystal structure of susb complexed with acarbose 21 c3eooL_ not modelled 59.5 15 PDB header:lyase Chain: L: PDB Molecule:methylisocitrate lyase; PDBTitle: 2.9a crystal structure of methyl-isocitrate lyase from2 burkholderia pseudomallei 22 c3amkA_ not modelled 55.6 18 PDB header:transferase Chain: A: PDB Molecule:os06g0726400 protein; PDBTitle: structure of the starch branching enzyme i (bei) from oryza sativa l 23 c3lyeA_ not modelled 55.3 15 PDB header:hydrolase Chain: A: PDB Molecule:oxaloacetate acetyl hydrolase; PDBTitle: crystal structure of oxaloacetate acetylhydrolase 24 d3elga1 not modelled 55.2 9 Fold:BLIP-like Superfamily:BT0923-like Family:BT0923-like 25 c2x4bA_ not modelled 54.7 22 PDB header:hydrolase Chain: A: PDB Molecule:limit dextrinase; PDBTitle: barley limit dextrinase in complex with beta-cyclodextrin 26 c1zcoA_ not modelled 54.7 14 PDB header:lyase Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphoheptonate aldolase; PDBTitle: crystal structure of pyrococcus furiosus 3-deoxy-d-arabino-2 heptulosonate 7-phosphate synthase 27 c1vs1B_ not modelled 54.2 11 PDB header:transferase Chain: B: PDB Molecule:3-deoxy-7-phosphoheptulonate synthase; PDBTitle: crystal structure of 3-deoxy-d-arabino-heptulosonate-7-2 phosphate synthase (dahp synthase) from aeropyrum pernix3 in complex with mn2+ and pep 28 d1nfpa_ not modelled 53.9 18 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:Non-fluorescent flavoprotein (luxF, FP390) 29 c2dh3A_ not modelled 51.8 12 PDB header:transport protein, signaling protein Chain: A: PDB Molecule:4f2 cell-surface antigen heavy chain; PDBTitle: crystal structure of human ed-4f2hc 30 d2duya1 not modelled 50.2 8 Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:ComEA-like 31 c3lotC_ not modelled 48.1 15 PDB header:structure genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function (np_070038.1) from2 archaeoglobus fulgidus at 1.89 a resolution 32 c3ktcB_ not modelled 46.2 11 PDB header:isomerase Chain: B: PDB Molecule:xylose isomerase; PDBTitle: crystal structure of putative sugar isomerase (yp_050048.1) from2 erwinia carotovora atroseptica scri1043 at 1.54 a resolution 33 c3amlA_ not modelled 45.4 18 PDB header:transferase Chain: A: PDB Molecule:os06g0726400 protein; PDBTitle: structure of the starch branching enzyme i (bei) from oryza sativa l 34 c1m7xC_ not modelled 45.0 21 PDB header:transferase Chain: C: PDB Molecule:1,4-alpha-glucan branching enzyme; PDBTitle: the x-ray crystallographic structure of branching enzyme 35 c3blpX_ not modelled 44.4 17 PDB header:hydrolase Chain: X: PDB Molecule:alpha-amylase 1; PDBTitle: role of aromatic residues in human salivary alpha-amylase 36 d2bhua3 not modelled 44.3 16 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 37 d1a9xb2 not modelled 41.9 23 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:Class I glutamine amidotransferases (GAT) 38 d2aq0a1 not modelled 41.6 18 Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:Hef domain-like 39 c1keeH_ not modelled 41.2 25 PDB header:ligase Chain: H: PDB Molecule:carbamoyl-phosphate synthetase small chain; PDBTitle: inactivation of the amidotransferase activity of carbamoyl phosphate2 synthetase by the antibiotic acivicin 40 c3lfjB_ not modelled 40.9 10 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase system, mannose/fructose/n- PDBTitle: crystal structure of manxb from thermoanaerobacter tengcongensis 41 c2l69A_ not modelled 40.4 19 PDB header:de novo protein Chain: A: PDB Molecule:rossmann 2x3 fold protein; PDBTitle: solution nmr structure of de novo designed protein, p-loop ntpase2 fold, northeast structural genomics consortium target or28 42 d1hl2a_ not modelled 39.1 16 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 43 c3c6cA_ not modelled 39.1 21 PDB header:hydrolase Chain: A: PDB Molecule:3-keto-5-aminohexanoate cleavage enzyme; PDBTitle: crystal structure of a putative 3-keto-5-aminohexanoate cleavage2 enzyme (reut_c6226) from ralstonia eutropha jmp134 at 1.72 a3 resolution 44 c3m07A_ not modelled 38.9 20 PDB header:unknown function Chain: A: PDB Molecule:putative alpha amylase; PDBTitle: 1.4 angstrom resolution crystal structure of putative alpha2 amylase from salmonella typhimurium. 45 c1ehaA_ not modelled 38.8 20 PDB header:hydrolase Chain: A: PDB Molecule:glycosyltrehalose trehalohydrolase; PDBTitle: crystal structure of glycosyltrehalose trehalohydrolase2 from sulfolobus solfataricus 46 d1wkya2 not modelled 38.4 9 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-glycanases 47 c3no5C_ not modelled 37.5 14 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a pfam duf849 domain containing protein2 (reut_a1631) from ralstonia eutropha jmp134 at 1.90 a resolution 48 c2v9dB_ not modelled 36.6 17 PDB header:lyase Chain: B: PDB Molecule:yage; PDBTitle: crystal structure of yage, a prophage protein belonging to2 the dihydrodipicolinic acid synthase family from e. coli3 k12 49 c3noeA_ not modelled 36.6 20 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa 50 c3e02A_ not modelled 36.2 14 PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein duf849; PDBTitle: crystal structure of a duf849 family protein (bxe_c0271) from2 burkholderia xenovorans lb400 at 1.90 a resolution 51 d1muma_ not modelled 35.6 16 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 52 d1cmwa2 not modelled 35.2 13 Fold:PIN domain-like Superfamily:PIN domain-like Family:5' to 3' exonuclease catalytic domain 53 c3jugA_ not modelled 35.0 8 PDB header:hydrolase Chain: A: PDB Molecule:beta-mannanase; PDBTitle: crystal structure of endo-beta-1,4-mannanase from the alkaliphilic2 bacillus sp. n16-5 54 c3e96B_ not modelled 34.6 17 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 bacillus clausii 55 c1lwhA_ not modelled 34.6 16 PDB header:transferase Chain: A: PDB Molecule:4-alpha-glucanotransferase; PDBTitle: crystal structure of t. maritima 4-alpha-glucanotransferase 56 c3efyB_ not modelled 34.0 23 PDB header:cell cycle Chain: B: PDB Molecule:cif (cell cycle inhibiting factor); PDBTitle: structure of the cyclomodulin cif from pathogenic2 escherichia coli 57 c3fkkA_ not modelled 33.9 17 PDB header:lyase Chain: A: PDB Molecule:l-2-keto-3-deoxyarabonate dehydratase; PDBTitle: structure of l-2-keto-3-deoxyarabonate dehydratase 58 d1lwha2 not modelled 33.8 16 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 59 c3k8kB_ not modelled 33.7 23 PDB header:membrane protein Chain: B: PDB Molecule:alpha-amylase, susg; PDBTitle: crystal structure of susg 60 c1x60A_ not modelled 33.6 18 PDB header:hydrolase Chain: A: PDB Molecule:sporulation-specific n-acetylmuramoyl-l-alanine PDBTitle: solution structure of the peptidoglycan binding domain of2 b. subtilis cell wall lytic enzyme cwlc 61 c1cmwA_ not modelled 33.3 13 PDB header:transferase Chain: A: PDB Molecule:protein (dna polymerase i); PDBTitle: crystal structure of taq dna-polymerase shows a new2 orientation for the structure-specific nuclease domain 62 c3b4uB_ not modelled 33.2 12 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from agrobacterium2 tumefaciens str. c58 63 d1lvaa3 not modelled 32.9 6 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:C-terminal fragment of elongation factor SelB 64 d1gvfa_ not modelled 32.7 8 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class II FBP aldolase 65 c2fhfA_ not modelled 32.1 22 PDB header:hydrolase Chain: A: PDB Molecule:pullulanase; PDBTitle: crystal structure analysis of klebsiella pneumoniae2 pullulanase complexed with maltotetraose 66 c3dx5A_ not modelled 32.1 8 PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein asbf; PDBTitle: crystal structure of the probable 3-dhs dehydratase asbf involved in2 the petrobactin synthesis from bacillus anthracis 67 d1sgga_ not modelled 32.0 7 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:SAM (sterile alpha motif) domain 68 c2dl0A_ not modelled 31.9 2 PDB header:signaling protein Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1; PDBTitle: solution structure of the sam-domain of the sam and sh32 domain containing protein 1 69 c3a47A_ not modelled 31.8 19 PDB header:hydrolase Chain: A: PDB Molecule:oligo-1,6-glucosidase; PDBTitle: crystal structure of isomaltase from saccharomyces cerevisiae 70 c3dz1A_ not modelled 31.5 16 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 rhodopseudomonas palustris at 1.87a resolution 71 d3bzka1 not modelled 31.3 6 Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:Tex HhH-containing domain-like 72 d1gxja_ not modelled 31.0 19 Fold:Smc hinge domain Superfamily:Smc hinge domain Family:Smc hinge domain 73 d1m1nb_ not modelled 30.9 7 Fold:Chelatase-like Superfamily:"Helical backbone" metal receptor Family:Nitrogenase iron-molybdenum protein 74 d2dvta1 not modelled 30.6 7 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like 75 d2a1ja1 not modelled 30.5 19 Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:Hef domain-like 76 c3f46A_ not modelled 30.4 14 PDB header:oxidoreductase Chain: A: PDB Molecule:5,10-methenyltetrahydromethanopterin hydrogenase; PDBTitle: the crystal structure of c176a mutated [fe]-hydrogenase (hmd)2 holoenzyme from methanocaldococcus jannaschii 77 c3n2xB_ not modelled 30.2 17 PDB header:lyase Chain: B: PDB Molecule:uncharacterized protein yage; PDBTitle: crystal structure of yage, a prophage protein belonging to the2 dihydrodipicolinic acid synthase family from e. coli k12 in complex3 with pyruvate 78 c1zjaB_ not modelled 30.1 23 PDB header:isomerase Chain: B: PDB Molecule:trehalulose synthase; PDBTitle: crystal structure of the trehalulose synthase mutb from2 pseudomonas mesoacidophila mx-45 (triclinic form) 79 d1m7xa3 not modelled 30.0 21 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 80 c3t4cD_ not modelled 29.2 18 PDB header:transferase Chain: D: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase 1; PDBTitle: crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from2 burkholderia ambifaria 81 c1uokA_ not modelled 29.0 17 PDB header:glucosidase Chain: A: PDB Molecule:oligo-1,6-glucosidase; PDBTitle: crystal structure of b. cereus oligo-1,6-glucosidase 82 d1avaa2 not modelled 28.7 14 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 83 c1xyzA_ not modelled 28.7 10 PDB header:glycosyltransferase Chain: A: PDB Molecule:1,4-beta-d-xylan-xylanohydrolase; PDBTitle: a common protein fold and similar active site in two2 distinct families of beta-glycanases 84 d1xyza_ not modelled 28.7 10 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-glycanases 85 d2qswa1 not modelled 28.5 14 Fold:Ferredoxin-like Superfamily:ACT-like Family:NIL domain-like 86 c3pm6B_ not modelled 28.4 18 PDB header:lyase Chain: B: PDB Molecule:putative fructose-bisphosphate aldolase; PDBTitle: crystal structure of a putative fructose-1,6-biphosphate aldolase from2 coccidioides immitis solved by combined sad mr 87 c1qysA_ not modelled 28.3 23 PDB header:de novo protein Chain: A: PDB Molecule:top7; PDBTitle: crystal structure of top7: a computationally designed2 protein with a novel fold 88 d1ujqa_ not modelled 27.9 13 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 89 c1zrjA_ not modelled 27.0 15 PDB header:dna binding protein Chain: A: PDB Molecule:e1b-55kda-associated protein 5 isoform c; PDBTitle: solution structure of the sap domain of human e1b-55kda-2 associated protein 5 isoform c 90 c3c52B_ not modelled 26.9 12 PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: class ii fructose-1,6-bisphosphate aldolase from2 helicobacter pylori in complex with3 phosphoglycolohydroxamic acid, a competitive inhibitor 91 c3hilB_ not modelled 26.8 7 PDB header:transferase Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: sam domain of human ephrin type-a receptor 1 (epha1) 92 c2jvfA_ not modelled 26.7 28 PDB header:de novo protein Chain: A: PDB Molecule:de novo protein m7; PDBTitle: solution structure of m7, a computationally-designed2 artificial protein 93 d1wg8a1 not modelled 26.4 18 Fold:SAM domain-like Superfamily:Putative methyltransferase TM0872, insert domain Family:Putative methyltransferase TM0872, insert domain 94 c2by0A_ not modelled 26.3 16 PDB header:hydrolase Chain: A: PDB Molecule:maltooligosyltrehalose trehalohydrolase; PDBTitle: is radiation damage dependent on the dose-rate used during2 macromolecular crystallography data collection 95 d1thta_ not modelled 26.3 12 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Thioesterases 96 c3elfA_ not modelled 26.2 14 PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: structural characterization of tetrameric mycobacterium tuberculosis2 fructose 1,6-bisphosphate aldolase - substrate binding and catalysis3 mechanism of a class iia bacterial aldolase 97 c1bf2A_ not modelled 26.2 13 PDB header:hydrolase Chain: A: PDB Molecule:isoamylase; PDBTitle: structure of pseudomonas isoamylase 98 c2fmmE_ not modelled 26.2 18 PDB header:transcription Chain: E: PDB Molecule:protein emsy; PDBTitle: crystal structure of emsy-hp1 complex 99 d2b0ja2 not modelled 26.1 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:6-phosphogluconate dehydrogenase-like, N-terminal domain 100 d1gjwa2 not modelled 25.3 20 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 101 c2k4pA_ not modelled 24.7 16 PDB header:signaling protein Chain: A: PDB Molecule:phosphatidylinositol-3,4,5-trisphosphate 5- PDBTitle: solution structure of ship2-sam 102 d1eh9a3 not modelled 24.6 17 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 103 c3p3vB_ not modelled 24.4 11 PDB header:transferase Chain: B: PDB Molecule:pts system, n-acetylgalactosamine-specific iib component; PDBTitle: crystal structure of a pts dependent n-acetyl-galactosamine-iib2 component (agav, spy_0631) from streptococcus pyogenes at 1.65 a3 resolution 104 d2do1a1 not modelled 24.4 14 Fold:LEM/SAP HeH motif Superfamily:SAP domain Family:SAP domain 105 c2wanA_ not modelled 24.4 21 PDB header:hydrolase Chain: A: PDB Molecule:pullulanase; PDBTitle: pullulanase from bacillus acidopullulyticus 106 c1bagA_ not modelled 24.3 19 PDB header:alpha-amylase Chain: A: PDB Molecule:alpha-1,4-glucan-4-glucanohydrolase; PDBTitle: alpha-amylase from bacillus subtilis complexed with2 maltopentaose 107 c3l51B_ not modelled 24.3 16 PDB header:cell cycle Chain: B: PDB Molecule:structural maintenance of chromosomes protein 4; PDBTitle: crystal structure of the mouse condensin hinge domain 108 c3h5dD_ not modelled 24.3 13 PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: dihydrodipicolinate synthase from drug-resistant streptococcus2 pneumoniae 109 d2fmme1 not modelled 24.1 18 Fold:ENT-like Superfamily:ENT-like Family:Emsy N terminal (ENT) domain-like 110 d2jgra1 not modelled 23.6 24 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:Diacylglycerol kinase-like 111 c1s5lu_ not modelled 23.0 20 PDB header:photosynthesis Chain: U: PDB Molecule:photosystem ii 12 kda extrinsic protein; PDBTitle: architecture of the photosynthetic oxygen evolving center 112 d2fmpa1 not modelled 23.0 13 Fold:SAM domain-like Superfamily:DNA polymerase beta, N-terminal domain-like Family:DNA polymerase beta, N-terminal domain-like 113 c2zdsB_ not modelled 22.9 18 PDB header:dna binding protein Chain: B: PDB Molecule:putative dna-binding protein; PDBTitle: crystal structure of sco6571 from streptomyces coelicolor2 a3(2) 114 c2rfgB_ not modelled 22.8 17 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from hahella2 chejuensis at 1.5a resolution 115 c3cuxA_ not modelled 22.7 26 PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design 116 d1qh8b_ not modelled 22.6 5 Fold:Chelatase-like Superfamily:"Helical backbone" metal receptor Family:Nitrogenase iron-molybdenum protein 117 d1iv0a_ not modelled 22.5 11 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:Putative Holliday junction resolvase RuvX 118 d1o5ka_ not modelled 22.2 16 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 119 d1pcaa1 not modelled 22.1 18 Fold:Ferredoxin-like Superfamily:Protease propeptides/inhibitors Family:Pancreatic carboxypeptidase, activation domain 120 c3nwcA_ not modelled 21.9 17 PDB header:cell cycle Chain: A: PDB Molecule:smc protein; PDBTitle: crystal structure of the pyrococcus furiosus smc protein hinge domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0