Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP29351
DateWed Jul 10 14:09:17 BST 2013
Unique Job ID4b321fdaf40b60a6
SequenceMVRWFHRDLS ... Download FASTA

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:66.218 Y:84.894 Z:55.509
Model (left) based on template c3ps5A_
Top template information
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
Confidence and coverage
Confidence:100.0% Coverage: 89%
529 residues ( 89% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDF
Secondary structure 
SS confidence 
Disorder  ???????
?
?
??
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  YDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQA
Secondary structure 
SS confidence 
Disorder 
??
????
????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  ESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
Secondary structure 
SS confidence 
Disorder  ?
?
?
?
????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  SETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
Secondary structure 
SS confidence 
Disorder 
??
?
??????
?????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  KAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSD
Secondary structure 
SS confidence 
Disorder 
?
?
?
?
??????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  YINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNK
Secondary structure 
SS confidence 
Disorder 
?????
?
?
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  CVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDH
Secondary structure 
SS confidence 
Disorder 
?
????
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDC
Secondary structure 
SS confidence 
Disorder 
?????
??
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNIT
Secondary structure 
SS confidence 
Disorder 
??????????????????
Disorder confidence 
 
   .........550.........560.........570.........580.........590.....
Sequence  YPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK
Secondary structure 
SS confidence 
Disorder  ???????????????????????
?????????????????????????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 24%)
Alpha helix ( 31%)
Beta strand ( 23%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3ps5 chain A

3D model

Region: 1 - 529
Aligned: 529
Modelled: 529
Confidence: 100.0%
Identity: 95%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2b3o chain A

3D model

Region: 2 - 525
Aligned: 503
Modelled: 507
Confidence: 100.0%
Identity: 95%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 3 - 519
Aligned: 488
Modelled: 517
Confidence: 100.0%
Identity: 61%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 1ygu chain A

3D model

Region: 218 - 589
Aligned: 340
Modelled: 355
Confidence: 100.0%
Identity: 32%
PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide

Phyre2

PDB 1lar chain B

3D model

Region: 167 - 518
Aligned: 331
Modelled: 352
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar

Phyre2

PDB 2nlk chain A

3D model

Region: 217 - 589
Aligned: 327
Modelled: 355
Confidence: 100.0%
Identity: 39%
PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)

Phyre2

PDB 3sr9 chain A

3D model

Region: 167 - 518
Aligned: 327
Modelled: 352
Confidence: 100.0%
Identity: 35%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s;
PDBTitle: crystal structure of mouse ptpsigma

Phyre2

PDB 1wch chain A

3D model

Region: 211 - 524
Aligned: 290
Modelled: 314
Confidence: 100.0%
Identity: 38%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1fpr chain A

3D model

Region: 243 - 525
Aligned: 283
Modelled: 283
Confidence: 100.0%
Identity: 94%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1jln chain A

3D model

Region: 214 - 517
Aligned: 276
Modelled: 300
Confidence: 100.0%
Identity: 36%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2jjd chain A

3D model

Region: 167 - 517
Aligned: 329
Modelled: 340
Confidence: 100.0%
Identity: 31%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform

Phyre2

PDB 2nz6 chain A

3D model

Region: 214 - 524
Aligned: 276
Modelled: 306
Confidence: 100.0%
Identity: 33%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s

Phyre2

PDB 2shp chain A domain 1

3D model

Region: 216 - 519
Aligned: 279
Modelled: 304
Confidence: 100.0%
Identity: 64%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 3s3f chain A

3D model

Region: 213 - 517
Aligned: 283
Modelled: 305
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate

Phyre2

PDB 1lar chain A domain 1

3D model

Region: 220 - 528
Aligned: 287
Modelled: 309
Confidence: 100.0%
Identity: 39%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 3i36 chain A

3D model

Region: 218 - 517
Aligned: 280
Modelled: 297
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain

Phyre2

PDB 2pa5 chain A

3D model

Region: 211 - 518
Aligned: 282
Modelled: 305
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9

Phyre2

PDB 2c7s chain A

3D model

Region: 218 - 528
Aligned: 286
Modelled: 308
Confidence: 100.0%
Identity: 42%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution

Phyre2

PDB 2f71 chain A domain 1

3D model

Region: 222 - 535
Aligned: 293
Modelled: 309
Confidence: 100.0%
Identity: 33%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2bzl chain A

3D model

Region: 240 - 518
Aligned: 268
Modelled: 279
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution

Phyre2
1
c3ps5A_
2
c2b3oA_
3
c2shpA_
4
c1yguA_
5
c1larB_
6
c2nlkA_
7
c3sr9A_
8
d1wcha_
9
d1fpra_
10
d1jlna_
11
c2jjdA_
12
c2nz6A_
13
d2shpa1
14
c3s3fA_
15
d1lara1
16
c3i36A_
17
c2pa5A_
18
c2c7sA_
19
d2f71a1
20
c2bzlA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3ps5A_
100.0 95 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
2c2b3oA_
100.0 95 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
3c2shpA_
100.0 61 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
4c1yguA_
100.0 32 PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide
5c1larB_
100.0 34 PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar
6c2nlkA_
100.0 39 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)
7c3sr9A_
100.0 35 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s;
PDBTitle: crystal structure of mouse ptpsigma
8d1wcha_
100.0 38 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
9d1fpra_
100.0 94 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
10d1jlna_
100.0 36 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
11c2jjdA_
100.0 31 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform
12c2nz6A_
100.0 33 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s
13d2shpa1
100.0 64 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
14c3s3fA_
100.0 37 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate
15d1lara1
100.0 39 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
16c3i36A_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain
17c2pa5A_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9
18c2c7sA_
100.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution
19d2f71a1
100.0 33 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
20c2bzlA_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution
21c2vexA_
not modelled 100.0 33 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1;
PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor
22c2hy3A_
not modelled 100.0 43 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma;
PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate
23d1rpma_
not modelled 100.0 40 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
24d1yfoa_
not modelled 100.0 39 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
25c2qdmA_
not modelled 100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7;
PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant
26c2h04A_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,;
PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors
27c2oc3A_
not modelled 100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18
28c3jrlA_
not modelled 100.0 61 PDB header:hydrolase
Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2;
PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor
29c2qcjB_
not modelled 100.0 38 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: native structure of lyp
30d1larb1
not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
31d1l8ka_
not modelled 100.0 36 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
32c1l8kA_
not modelled 100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase;
PDBTitle: t cell protein-tyrosine phosphatase structure
33c2g59B_
not modelled 100.0 36 PDB header:hydrolase
Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o;
PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens
34c2i75A_
not modelled 100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4;
PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
35c2qepA_
not modelled 100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2;
PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta)
36c2bijA_
not modelled 100.0 39 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5;
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase)
37c2b49A_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3;
PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3
38d1lara2
not modelled 100.0 38 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
39c1g4wR_
not modelled 100.0 14 PDB header:signaling protein
Chain: R: PDB Molecule:protein tyrosine phosphatase sptp;
PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp
40c3m4uB_
not modelled 100.0 31 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative;
PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1
41c4az1B_
not modelled 100.0 28 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase;
PDBTitle: crystal structure of the trypanosoma cruzi protein tyrosine2 phosphatase tcptp1, a potential therapeutic target for chagas'3 disease
42d1p15a_
not modelled 100.0 35 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
43d1lyva_
not modelled 100.0 19 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
44d1g4us2
not modelled 100.0 16 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
45c2oq1A_
not modelled 100.0 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
46c3gqiB_
not modelled 100.0 32 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
47c4fl2A_
not modelled 100.0 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
48c2ozoA_
not modelled 100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
49c1a81E_
not modelled 100.0 27 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
50c3or8A_
not modelled 100.0 18 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
51c2xp1A_
not modelled 100.0 20 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
52d1v3aa_
not modelled 100.0 20 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
53d1rxda_
not modelled 100.0 23 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
54c1x6cA_
not modelled 99.9 92 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
55c3rz2B_
not modelled 99.9 21 PDB header:hydrolase
Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1;
PDBTitle: crystal of prl-1 complexed with peptide
56c2fo0A_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
57c3s4oB_
not modelled 99.9 18 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein;
PDBTitle: protein tyrosine phosphatase (putative) from leishmania major
58c1oplA_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
59c1y57A_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
60c2ablA_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
61d2oq1a1
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62c2h8hA_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
63c1k9aB_
not modelled 99.9 30 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
64c2ci8A_
not modelled 99.9 37 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
65c2y3aB_
not modelled 99.9 33 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
66d2shpa3
not modelled 99.9 52 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67d3c7ia1
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68c2hdxB_
not modelled 99.9 27 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
69c2eobA_
not modelled 99.9 27 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
70c3nhnA_
not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
71d2shpa2
not modelled 99.9 65 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72c2c0iA_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
73c1x27F_
not modelled 99.9 27 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
74c3hizB_
not modelled 99.9 20 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
75c2eo6A_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
76c1g83A_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
77d1fhsa_
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c2dlzA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
79c2gsbA_
not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
80d1ayaa_
not modelled 99.9 64 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2lqnA_
not modelled 99.9 33 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
82c2crhA_
not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
83d2oq1a2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d1rjaa_
not modelled 99.9 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85d1a81a1
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86d1pica_
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87c2lctA_
not modelled 99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
88d1nrva_
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c2ge9A_
not modelled 99.9 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
90c2el8A_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
91c2dlyA_
not modelled 99.8 33 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
92d1a81a2
not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
93d1lkka_
not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1a81e2
not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c2eo3A_
not modelled 99.8 33 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
96d2izva2
not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97d1blja_
not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98d1bkla_
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
99c2ysxA_
not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
100d1f2fa_
not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101c2kk6A_
not modelled 99.8 31 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
102d1jyra_
not modelled 99.8 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
103d1a81e1
not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1o48a_
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105d1qada_
not modelled 99.8 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106d1qcfa2
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
107d1r1qa_
not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
108d1jwoa_
not modelled 99.8 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
109d1g83a2
not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
110d1k9aa2
not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
111c2vifA_
not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
112d1mila_
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
113d1d4ta_
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
114c2cr4A_
not modelled 99.8 18 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
115d1luia_
not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
116d1opka2
not modelled 99.8 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
117c2dcrA_
not modelled 99.8 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
118c2c9wA_
not modelled 99.8 22 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
119d2eyva1
not modelled 99.8 40 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
120d1ohea2
not modelled 99.8 29 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like

Binding site prediction 

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite