PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.0

Fold library entry viewer: c3jrlA_

Fold library id	PDB Header	Molecule	Title
c3jrlA_	PDB header: hydrolase	Chain: A: PDB Molecule: oncogenic tyrosine phosphatase shp2;	PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor

Links to external resources
Added to library: Sun Aug 29 08:24:16 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence L Y S R K E G Q R Q E N K N K N R Y K N I L P F D H T R V V L H D G D P N E P V S D Y I N A N I I M P K K S Y I A T Q G C L Q N T V N D F W

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G S G G G G G G
S S T T
T T T B
S
T T S S
S
S
T T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence R M V F Q E N S R V I V M T T K E V E R G K S K C V K Y W P D E Y A L K E Y G V M R V R N V K E S A A H D Y T L R E L K L S K V G Q G N T E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
S T T
S
T T
T T
S S T T
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence R T V W Q Y H F R T W P D H G V P S D P G G V L D F L E E V H H K Q E S I M D A G P V V V H C S A G I G R T G T F I V I D I L I D I I R E K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S
S S T T S T T
S S S S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . .

Sequence G V D C D I D V P K T I Q M V R S Q R S G M V Q T E A Q Y R F I Y M A V Q H Y I E T L Q R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
T T S T T
S
S T

Download: PDB structure FASTA sequence
Hidden Markov model

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Please cite: The Phyre2 web portal for protein modeling, prediction and analysis

Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	L	Y	S	R	K	E	G	Q	R	Q	E	N	K	N	K	N	R	Y	K	N	I	L	P	F	D	H	T	R	V	V	L	H	D	G	D	P	N	E	P	V	S	D	Y	I	N	A	N	I	I	M	P	K	K	S	Y	I	A	T	Q	G	C	L	Q	N	T	V	N	D	F	W
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						G	G	G	S	G	G	G	G	G	G		S	S	T	T					T	T	T	B					S			T	T	S	S			S			S																		T	T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	R	M	V	F	Q	E	N	S	R	V	I	V	M	T	T	K	E	V	E	R	G	K	S	K	C	V	K	Y	W	P	D	E	Y	A	L	K	E	Y	G	V	M	R	V	R	N	V	K	E	S	A	A	H	D	Y	T	L	R	E	L	K	L	S	K	V	G	Q	G	N	T	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T	T								S		S			T	T								S			T	T						T	T												S	S											T	T		S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	R	T	V	W	Q	Y	H	F	R	T	W	P	D	H	G	V	P	S	D	P	G	G	V	L	D	F	L	E	E	V	H	H	K	Q	E	S	I	M	D	A	G	P	V	V	V	H	C	S	A	G	I	G	R	T	G	T	F	I	V	I	D	I	L	I	D	I	I	R	E	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													S	S	S			S	S	T																T	S	T	T									S	S	S	S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.
Sequence	G	V	D	C	D	I	D	V	P	K	T	I	Q	M	V	R	S	Q	R	S	G	M	V	Q	T	E	A	Q	Y	R	F	I	Y	M	A	V	Q	H	Y	I	E	T	L	Q	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T	S													T	T	S	T	T		S		S																			T