Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ96IW2
DateSat Jun 16 10:30:30 BST 2012
Unique Job ID9730485162c2534d

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2eo6A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
Confidence and coverage
Confidence:100.0% Coverage: 36%
122 residues ( 36% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Warning: 66% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFEDPYEDAESRLEPDPAGP
Secondary structure 
SS confidence 
Disorder  ??
??????????????????????????????????????????????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  GDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADTEYLDPFDAQPHPAPPD
Secondary structure 
SS confidence 
Disorder  ???????????????????????????????????????????????
????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  DGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPPSGQKPRQSRMPQEDERPADE
Secondary structure 
SS confidence 
Disorder  ???????????????????????????
????????????????????????????????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  YDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPPPRSPQPAERVDPALPLEKQPW
Secondary structure 
SS confidence 
Disorder  ???
??
???
??
???
???????????????????????????????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  FHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLG
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........310.........320.........330.........340
Sequence  QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQTP
Secondary structure 
SS confidence 
Disorder 
???????
?????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2eo6 chain A

3D model

Region: 217 - 338
Aligned: 122
Modelled: 122
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2y3a chain B

3D model

Region: 235 - 337
Aligned: 101
Modelled: 103
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 1pic chain A

3D model

Region: 230 - 340
Aligned: 109
Modelled: 111
Confidence: 99.9%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2crh chain A

3D model

Region: 214 - 335
Aligned: 120
Modelled: 122
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 3c7i chain A domain 1

3D model

Region: 235 - 335
Aligned: 99
Modelled: 101
Confidence: 99.9%
Identity: 31%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2lqn chain A

3D model

Region: 229 - 340
Aligned: 107
Modelled: 110
Confidence: 99.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 3hiz chain B

3D model

Region: 234 - 335
Aligned: 97
Modelled: 102
Confidence: 99.9%
Identity: 29%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2eo3 chain A

3D model

Region: 221 - 335
Aligned: 108
Modelled: 115
Confidence: 99.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 2c9w chain A

3D model

Region: 235 - 340
Aligned: 99
Modelled: 106
Confidence: 99.9%
Identity: 26%
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 233 - 338
Aligned: 101
Modelled: 106
Confidence: 99.9%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2gsb chain A

3D model

Region: 224 - 340
Aligned: 111
Modelled: 117
Confidence: 99.9%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2

PDB 2dlz chain A

3D model

Region: 233 - 335
Aligned: 101
Modelled: 103
Confidence: 99.9%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 1fhs chain A

3D model

Region: 232 - 335
Aligned: 102
Modelled: 104
Confidence: 99.9%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2fo0 chain A

3D model

Region: 224 - 340
Aligned: 112
Modelled: 117
Confidence: 99.9%
Identity: 33%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 2oq1 chain A

3D model

Region: 233 - 335
Aligned: 98
Modelled: 103
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2dly chain A

3D model

Region: 224 - 340
Aligned: 112
Modelled: 117
Confidence: 99.9%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase

Phyre2

PDB 2vif chain A

3D model

Region: 224 - 335
Aligned: 111
Modelled: 112
Confidence: 99.9%
Identity: 30%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 2shp chain A domain 2

3D model

Region: 236 - 340
Aligned: 103
Modelled: 105
Confidence: 99.9%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2abl chain A

3D model

Region: 225 - 335
Aligned: 106
Modelled: 107
Confidence: 99.9%
Identity: 35%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 2kk6 chain A

3D model

Region: 230 - 335
Aligned: 101
Modelled: 102
Confidence: 99.9%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d

Phyre2
1
c2eo6A_
2
c2y3aB_
3
d1pica_
4
c2crhA_
5
d3c7ia1
6
c2lqnA_
7
c3hizB_
8
c2eo3A_
9
c2c9wA_
10
d2oq1a1
11
c2gsbA_
12
c2dlzA_
13
d1fhsa_
14
c2fo0A_
15
c2oq1A_
16
c2dlyA_
17
c2vifA_
18
d2shpa2
19
c2ablA_
20
c2kk6A_
21
22
23
24
25
26
27
28
29
30
31
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2eo6A_
100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
2c2y3aB_
99.9 28 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
3d1pica_
99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
4c2crhA_
99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
5d3c7ia1
99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
6c2lqnA_
99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
7c3hizB_
99.9 29 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
8c2eo3A_
99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
9c2c9wA_
99.9 26 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
10d2oq1a1
99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
11c2gsbA_
99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
12c2dlzA_
99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
13d1fhsa_
99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
14c2fo0A_
99.9 33 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
15c2oq1A_
99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
16c2dlyA_
99.9 29 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
17c2vifA_
99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
18d2shpa2
99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
19c2ablA_
99.9 35 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
20c2kk6A_
99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
21c1ka6A_
not modelled 99.9 24 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
22c2hmhA_
not modelled 99.9 22 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
23c1x6cA_
not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
24c2shpA_
not modelled 99.9 31 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
25c2lctA_
not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
26d1qada_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
27c2eobA_
not modelled 99.9 29 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
28c2dcrA_
not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
29d1ayaa_
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1a81e1
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31d1blja_
not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
32c2b3oA_
not modelled 99.9 22 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
33d2izva2
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34d1opka2
not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35c2izvA_
not modelled 99.9 25 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
36d1a81e2
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d1r1qa_
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d1rjaa_
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39d1k9aa2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40d1d4ta_
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41d1mila_
not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42c2ci8A_
not modelled 99.9 34 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
43c2ysxA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
44d1a81a1
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c1oplA_
not modelled 99.9 35 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
46d2shpa3
not modelled 99.9 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d1lkka_
not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48c3gqiB_
not modelled 99.9 31 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
49d1g83a2
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d2oq1a2
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51d2cs0a1
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
52d1fu6a_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53d1jwoa_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54d1a81a2
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d2eyva1
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56d1csya_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57c2ozoA_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
58c2knoA_
not modelled 99.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
59d1luia_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d1jyra_
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c3ps5A_
not modelled 99.9 22 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
62d1nrva_
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c2ge9A_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
64d1i3za_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65d2c9wa2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66c3nhnA_
not modelled 99.9 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
67c1y57A_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
68d1o48a_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2ekxA_
not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
70d1qcfa2
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71c1x27F_
not modelled 99.9 34 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
72d1xa6a2
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
73d2qmsa1
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c1k9aB_
not modelled 99.9 28 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
75d1f2fa_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1bkla_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77c2c0iA_
not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
78d2fcia1
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79c3mazA_
not modelled 99.9 15 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
80c1a81E_
not modelled 99.9 20 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
81c2el8A_
not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
82c1g83A_
not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
83c2h8hA_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
84c2dm0A_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
85d1rpya_
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86c1rqqC_
not modelled 99.9 34 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
87d1cwea_
not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88c3gxxB_
not modelled 99.8 15 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
89c2eyzA_
not modelled 99.8 30 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
90c2cr4A_
not modelled 99.8 24 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
91c2dvjA_
not modelled 99.8 31 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
92c2eyyA_
not modelled 99.8 30 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
93c3qwxX_
not modelled 99.8 29 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
94c3qwyA_
not modelled 99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
95c2dx0B_
not modelled 99.8 37 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
96c3or8A_
not modelled 99.7 16 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
97c2xp1A_
not modelled 99.6 17 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
98c1xa6A_
not modelled 99.6 27 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
99d1uura3
not modelled 99.6 13 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
100d1bf5a3
not modelled 99.5 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101d1bg1a3
not modelled 99.4 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
102c3cblA_
not modelled 99.2 36 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
103c1yvlB_
not modelled 98.5 18 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
104c1uusA_
not modelled 98.4 20 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
105c1bf5A_
not modelled 98.3 18 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
106c2cblA_
not modelled 98.2 26 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
107c3bunB_
not modelled 98.2 26 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
108c1y1uA_
not modelled 98.2 22 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducer and activator of transcription 5a;
PDBTitle: structure of unphosphorylated stat5a
109c1bg1A_
not modelled 98.1 18 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
110c3cwgA_
not modelled 96.7 20 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
111c1fbvA_
not modelled 93.4 26 PDB header:ligase
Chain: A: PDB Molecule:signal transduction protein cbl;
PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases
112c1griA_
not modelled 93.4 36 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
113d3buxb3
not modelled 90.5 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
114c3op0B_
not modelled 85.9 28 PDB header:signaling protein/signaling protein regu
Chain: B: PDB Molecule:signal transduction protein cbl-c;
PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide
115c2yt6A_
not modelled 68.7 37 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
116d2d7na1
not modelled 63.2 17 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
117d2e9ia1
not modelled 62.3 14 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
118d1wlha1
not modelled 62.1 17 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
119d1qfha1
not modelled 58.9 10 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
120d2di9a1
not modelled 58.3 17 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)

Binding site prediction 

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