Phyre 2 Results for P15498

Email	l.a.kelley@imperial.ac.uk
Description	P15498
Date	Fri May 25 09:26:45 BST 2012
Unique Job ID	ff87a0345eec4754

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3ky9B_

Top template information

PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Confidence and coverage

Confidence:

100.0%

Coverage:

64%

540 residues ( 64% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

771 residues ( 91%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M E L W R Q C T H W L I Q C R V L P P S H R V T W D G A Q V C E L A Q A L R D G V L L C Q L L N N L L P H A I N L R E V

Secondary structure

SS confidence

Disorder ? ? ?
? ? ?
? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence N L R P Q M S Q F L C L K N I R T F L S T C C E K F G L K R S E L F E A F D L F D V Q D F G K V I Y T L S A L S W T P I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence A Q N R G I M P F P T E E E S V G D E D I Y S G L S D Q I D D T V E E D E D L Y D C V E N E E A E G D E I Y E D L M R S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence E P V S M P P K M T E Y D K R C C C L R E I Q Q T E E K Y T D T L G S I Q Q H F L K P L Q R F L K P Q D I E I I F I N I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E D L L R V H T H F L K E M K E A L G T P G A A N L Y Q V F I K Y K E R F L V Y G R Y C S Q V E S A S K H L D R V A A A

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence R E D V Q M K L E E C S Q R A N N G R F T L R D L L M V P M Q R V L K Y H L L L Q E L V K H T Q E A M E K E N L R L A L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence D A M R D L A Q C V N E V K R D N E T L R Q I T N F Q L S I E N L D Q S L A H Y G R P K I D G E L K I T S V E R R S K M

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence D R Y A F L L D K A L L I C K R R G D S Y D L K D F V N L H S F Q V R D D S S G D R D N K K W S H M F L L I E D Q G A Q

Secondary structure

SS confidence

Disorder
? ?
?
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence G Y E L F F K T R E L K K K W M E Q F E M A I S N I Y P E N A T A N G H D F Q M F S F E E T T S C K A C Q M L L R G T F

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence Y Q G Y R C H R C R A S A H K E C L G R V P P C G R H G Q D F P G T M K K D K L H R R A Q D K K R N E L G L P K M E V F

Secondary structure

SS confidence

Disorder ? ?
? ? ? ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence Q E Y Y G L P P P P G A I G P F L R L N P G D I V E L T K A E A E Q N W W E G R N T S T N E I G W F P C N R V K P Y V H

Secondary structure

SS confidence

Disorder ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence G P P Q D L S V H L W Y A G P M E R A G A E S I L A N R S D G T F L V R Q R V K D A A E F A I S I K Y N V E V K H I K I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence M T A E G L Y R I T E K K A F R G L T E L V E F Y Q Q N S L K D C F K S L D T T L Q F P F K E P E K R T I S R P A V G S

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence T K Y F G T A K A R Y D F C A R D R S E L S L K E G D I I K I L N K K G Q Q G W W R G E I Y G R V G W F P A N Y V E E D

Secondary structure

SS confidence

Disorder ? ?
? ?
? ? ?
?

Disorder confidence

. . . . .

Sequence Y S E Y C

Secondary structure

SS confidence

Disorder ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3ky9 chain B

Region: 2 - 565
Aligned: 540
Modelled: 564
Confidence: 100.0%
Identity: 99%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 2vrw chain B

Region: 190 - 564
Aligned: 367
Modelled: 375
Confidence: 100.0%
Identity: 94%
PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor

Phyre2

PDB 3bji chain A

Region: 189 - 565
Aligned: 372
Modelled: 377
Confidence: 100.0%
Identity: 99%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1

Phyre2

PDB 3ksy chain A

Region: 194 - 505
Aligned: 303
Modelled: 312
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)

Phyre2

PDB 2dx1 chain A

Region: 139 - 507
Aligned: 351
Modelled: 352
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 1xdv chain B

Region: 195 - 505
Aligned: 300
Modelled: 311
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.

Phyre2

PDB 3odo chain A

Region: 191 - 505
Aligned: 309
Modelled: 315
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef

Phyre2

PDB 2dfk chain A

Region: 189 - 515
Aligned: 326
Modelled: 327
Confidence: 100.0%
Identity: 25%
PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex

Phyre2

PDB 1xcg chain A

Region: 180 - 505
Aligned: 321
Modelled: 326
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef

Phyre2

PDB 1x86 chain A

Region: 189 - 509
Aligned: 315
Modelled: 321
Confidence: 100.0%
Identity: 23%
PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa

Phyre2

PDB 3t06 chain E

Region: 179 - 505
Aligned: 322
Modelled: 327
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa

Phyre2

PDB 1foe chain A

Region: 188 - 509
Aligned: 320
Modelled: 322
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1

Phyre2

PDB 2rgn chain B

Region: 191 - 505
Aligned: 290
Modelled: 315
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa

Phyre2

PDB 3mpx chain A

Region: 193 - 502
Aligned: 290
Modelled: 310
Confidence: 100.0%
Identity: 17%
PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5

Phyre2

PDB 3odx chain A

Region: 190 - 509
Aligned: 310
Modelled: 320
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef

Phyre2

PDB 3odw chain B

Region: 194 - 507
Aligned: 306
Modelled: 314
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef

Phyre2

PDB 2z0q chain A

Region: 189 - 504
Aligned: 297
Modelled: 302
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)

Phyre2

PDB 1ki1 chain B

Region: 189 - 514
Aligned: 313
Modelled: 326
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42

Phyre2

PDB 1dbh chain A

Region: 193 - 505
Aligned: 304
Modelled: 313
Confidence: 100.0%
Identity: 20%
PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1

Phyre2

PDB 1lb1 chain C

Region: 194 - 505
Aligned: 293
Modelled: 312
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa

Phyre2

PDB 1gri chain A

Region: 601 - 839
Aligned: 206
Modelled: 206
Confidence: 100.0%
Identity: 25%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2eyy chain A

Region: 664 - 839
Aligned: 175
Modelled: 175
Confidence: 99.9%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i

Phyre2

PDB 2lqn chain A

Region: 658 - 838
Aligned: 178
Modelled: 178
Confidence: 99.9%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2dvj chain A

Region: 665 - 839
Aligned: 165
Modelled: 165
Confidence: 99.9%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii

Phyre2

PDB 3qwx chain X

Region: 665 - 839
Aligned: 153
Modelled: 153
Confidence: 99.9%
Identity: 25%
PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174

Phyre2

PDB 3qwy chain A

Region: 665 - 840
Aligned: 154
Modelled: 154
Confidence: 99.9%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2

Phyre2

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	E	L	W	R	Q	C	T	H	W	L	I	Q	C	R	V	L	P	P	S	H	R	V	T	W	D	G	A	Q	V	C	E	L	A	Q	A	L	R	D	G	V	L	L	C	Q	L	L	N	N	L	L	P	H	A	I	N	L	R	E	V
Secondary structure
SS confidence
Disorder	?	?	?														?	?	?		?	?	?	?	?	?																													?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	N	L	R	P	Q	M	S	Q	F	L	C	L	K	N	I	R	T	F	L	S	T	C	C	E	K	F	G	L	K	R	S	E	L	F	E	A	F	D	L	F	D	V	Q	D	F	G	K	V	I	Y	T	L	S	A	L	S	W	T	P	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																																																	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	A	Q	N	R	G	I	M	P	F	P	T	E	E	E	S	V	G	D	E	D	I	Y	S	G	L	S	D	Q	I	D	D	T	V	E	E	D	E	D	L	Y	D	C	V	E	N	E	E	A	E	G	D	E	I	Y	E	D	L	M	R	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	E	P	V	S	M	P	P	K	M	T	E	Y	D	K	R	C	C	C	L	R	E	I	Q	Q	T	E	E	K	Y	T	D	T	L	G	S	I	Q	Q	H	F	L	K	P	L	Q	R	F	L	K	P	Q	D	I	E	I	I	F	I	N	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	D	L	L	R	V	H	T	H	F	L	K	E	M	K	E	A	L	G	T	P	G	A	A	N	L	Y	Q	V	F	I	K	Y	K	E	R	F	L	V	Y	G	R	Y	C	S	Q	V	E	S	A	S	K	H	L	D	R	V	A	A	A
Secondary structure
SS confidence
Disorder																							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	R	E	D	V	Q	M	K	L	E	E	C	S	Q	R	A	N	N	G	R	F	T	L	R	D	L	L	M	V	P	M	Q	R	V	L	K	Y	H	L	L	L	Q	E	L	V	K	H	T	Q	E	A	M	E	K	E	N	L	R	L	A	L
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?																													?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	D	A	M	R	D	L	A	Q	C	V	N	E	V	K	R	D	N	E	T	L	R	Q	I	T	N	F	Q	L	S	I	E	N	L	D	Q	S	L	A	H	Y	G	R	P	K	I	D	G	E	L	K	I	T	S	V	E	R	R	S	K	M
Secondary structure
SS confidence
Disorder																																	?	?	?	?																		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	D	R	Y	A	F	L	L	D	K	A	L	L	I	C	K	R	R	G	D	S	Y	D	L	K	D	F	V	N	L	H	S	F	Q	V	R	D	D	S	S	G	D	R	D	N	K	K	W	S	H	M	F	L	L	I	E	D	Q	G	A	Q
Secondary structure
SS confidence
Disorder																		?	?		?									?								?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	G	Y	E	L	F	F	K	T	R	E	L	K	K	K	W	M	E	Q	F	E	M	A	I	S	N	I	Y	P	E	N	A	T	A	N	G	H	D	F	Q	M	F	S	F	E	E	T	T	S	C	K	A	C	Q	M	L	L	R	G	T	F
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	Y	Q	G	Y	R	C	H	R	C	R	A	S	A	H	K	E	C	L	G	R	V	P	P	C	G	R	H	G	Q	D	F	P	G	T	M	K	K	D	K	L	H	R	R	A	Q	D	K	K	R	N	E	L	G	L	P	K	M	E	V	F
Secondary structure
SS confidence
Disorder	?	?		?	?	?	?		?		?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	Q	E	Y	Y	G	L	P	P	P	P	G	A	I	G	P	F	L	R	L	N	P	G	D	I	V	E	L	T	K	A	E	A	E	Q	N	W	W	E	G	R	N	T	S	T	N	E	I	G	W	F	P	C	N	R	V	K	P	Y	V	H
Secondary structure
SS confidence
Disorder	?		?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?						?	?	?	?	?	?	?								?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	G	P	P	Q	D	L	S	V	H	L	W	Y	A	G	P	M	E	R	A	G	A	E	S	I	L	A	N	R	S	D	G	T	F	L	V	R	Q	R	V	K	D	A	A	E	F	A	I	S	I	K	Y	N	V	E	V	K	H	I	K	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?													?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	M	T	A	E	G	L	Y	R	I	T	E	K	K	A	F	R	G	L	T	E	L	V	E	F	Y	Q	Q	N	S	L	K	D	C	F	K	S	L	D	T	T	L	Q	F	P	F	K	E	P	E	K	R	T	I	S	R	P	A	V	G	S
Secondary structure
SS confidence
Disorder												?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	T	K	Y	F	G	T	A	K	A	R	Y	D	F	C	A	R	D	R	S	E	L	S	L	K	E	G	D	I	I	K	I	L	N	K	K	G	Q	Q	G	W	W	R	G	E	I	Y	G	R	V	G	W	F	P	A	N	Y	V	E	E	D
Secondary structure
SS confidence
Disorder	?	?																?	?			?	?	?																																				?
Disorder confidence

	.	.	.	.	.
Sequence	Y	S	E	Y	C
Secondary structure
SS confidence
Disorder	?	?	?	?	?
Disorder confidence