Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ7KV33
DateTue Jan 22 11:34:33 GMT 2013
Unique Job IDd95adb05d880fe9d

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2eo6A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
Confidence and coverage
Confidence: 99.9% Coverage: 7%
101 residues ( 7% of your sequence) have been modelled with 99.9% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
181 residues ( 12%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
Warning: 75% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MFCRLCWIDFNAGEAMVECAGPCGSCFHRNCVDCVTGDVAHILATGGGYYSGLEWYCRTC
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   .........70.........80.........90.........100.........110.........120
Sequence  RQLYRLQVYFEIAICDDYSLPVDFVKKRPSSFDPCLAEAIPANPEHWIAPSPQTEFLPFG
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???
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   .........130.........140.........150.........160.........170.........180
Sequence  EAQQALQLQPAAAAATAAATTSAAAAANATAAAPQLPPPLPVPVATLPNQAATAAAAATA
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Disorder  ??????????





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   .........190.........200.........210.........220.........230.........240
Sequence  AILATHQQQQQQQHQHLSNNNNNGGSTHGQQHTHSNNNNTLPVGAQQQQQQQHQQQRATL
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Disorder 



?
???????????????????????????????????????










????
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   .........250.........260.........270.........280.........290.........300
Sequence  QHPPLPNSNIKQASVKLIEGYSDPKDTRNHKKVYHKKAKKRSTTGHKRHQQQQQQQQPHQ
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   .........310.........320.........330.........340.........350.........360
Sequence  QQLQQQQQQTLPTPRSAQQQQQLQQKLQQRHSTYNNNNGNSRKDKRNSQYNSDSSAPKSS
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???????????









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   .........370.........380.........390.........400.........410.........420
Sequence  DDEADIDEEVEQQPLPVPQAPVQSASQPAAGLNSPDSISDDLVRPLPPQLQRSPRKLTVA
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Disorder  ????????????????????????????????????????????????????????????
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   .........430.........440.........450.........460.........470.........480
Sequence  PAEHNKRQPSPYYYSDLLKSRDKDKDKDKDKDKDKDKDKDKDKDKDKERDKDREDFKLKC
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   .........490.........500.........510.........520.........530.........540
Sequence  RQSTASEPPQQTQTQLGGYRKSSSLDVPPAEEQPEAESHEEEDPRTGQDSQSTPKRYSFT
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Disorder  ????????????????????????????????????????????????????????????
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   .........550.........560.........570.........580.........590.........600
Sequence  EEGVHIIRCETPSTSTSEESDCSECLKRREWHARALALVRKTCNVQPRNQNPTGSELQLQ
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??

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   .........610.........620.........630.........640.........650.........660
Sequence  LQHCDAGEGELLKCCPPPPAPAENQSQVQPMPPHRLLGPAAVCGACITSAPASSLAGGRG
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Disorder  ????????????????????????????????????????
??
?
??????????????
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   .........670.........680.........690.........700.........710.........720
Sequence  SELGDDLEEEYFRPRSIFYVHPHGVHECIECAQPAQPATVPAPTLSNPSLDIYGDDEDEV
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   .........730.........740.........750.........760.........770.........780
Sequence  DGDEDEDEEDDSEDIMGSRRRQIYETAFDCKIAKSDDDLDEVDRITNCSVLLQLSNGNGG
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   .........790.........800.........810.........820.........830.........840
Sequence  DISKVTGSSKTRAECKRAKNSKNQALQEQTGEAHVQVHHVEAELGKLQLSQVDQQNQNQN
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   .........850.........860.........870.........880.........890.........900
Sequence  QSQNQQHGVSATGSGASASSTQQLPVRGYTPSPPSTAPLPMKFPGKHDRYLNMNSIRSAP
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?


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   .........910.........920.........930.........940.........950.........960
Sequence  NLPAANPAHPRLRDLRLPIQSMRHQCGGSSNDNSLTDSAYVNPPSTNSNSNAASASASAS
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   .........970.........980.........990.........1000.........1010.........1020
Sequence  VSATGSAAPRRPRSFVLESGRVLELRRSAQGHQGGQSTHHHHHHHHHAPGSRRNRHGQSQ
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   .........1030.........1040.........1050.........1060.........1070.........1080
Sequence  GQTTGGGHNYSSTESIATSSSGGSMESLRSSTSEGNRSTSSSESRHSSSLSSHSSESGSG
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   .........1090.........1100.........1110.........1120.........1130.........1140
Sequence  GSGGSGGSSVAYPLRPAPLLLHSKLHILSPISDKSSQEPASASASEQSQQPSQQLAPMAS
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Disorder  ???????????
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   .........1150.........1160.........1170.........1180.........1190.........1200
Sequence  QEDDSTTSGAPAGNQVQVNASLKQPRSNRGAPNKALLQLADELLGSDSGISLHSREDGKP
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?
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   .........1210.........1220.........1230.........1240.........1250.........1260
Sequence  QALALQRLTLPKLQLIGAEGTTTSATASGAGGSSATGGSSGAGGSGSGSVVASGSTGIQQ
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Disorder  ??
?????????????????????????????????????????????????????????
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   .........1270.........1280.........1290.........1300.........1310.........1320
Sequence  DLRDLPFDMPKLRRRKTLQQEAACTSGSATSVDLGELPFDMPKLRRRLRANQAEINNLLM
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?????

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   .........1330.........1340.........1350.........1360.........1370.........1380
Sequence  HSTESSGISQASSSHSMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGLNS
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   .........1390.........1400.........1410.........1420.........1430.........1440
Sequence  NKELNMNLSQGYVTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCEST
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   .........1450.........1460.........1470.........1480.........1490.........1500
Sequence  KQDYSLSLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMC
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Disorder  ??

























































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   .........1510
Sequence  LIEPVIAQLL
Secondary structure 




SS confidence 









Disorder 



??
???
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2eo6 chain A

3D model

Region: 1405 - 1505
Aligned: 101
Modelled: 101
Confidence: 99.9%
Identity: 31%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2hdx chain B

3D model

Region: 1404 - 1505
Aligned: 99
Modelled: 102
Confidence: 99.8%
Identity: 27%
PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide

Phyre2

PDB 2eo3 chain A

3D model

Region: 1391 - 1505
Aligned: 108
Modelled: 115
Confidence: 99.8%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 3hiz chain B

3D model

Region: 1405 - 1505
Aligned: 96
Modelled: 101
Confidence: 99.8%
Identity: 29%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 1mil chain A

3D model

Region: 1404 - 1509
Aligned: 101
Modelled: 104
Confidence: 99.8%
Identity: 33%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2shp chain A domain 2

3D model

Region: 1406 - 1505
Aligned: 98
Modelled: 100
Confidence: 99.8%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1fhs chain A

3D model

Region: 1403 - 1505
Aligned: 101
Modelled: 103
Confidence: 99.8%
Identity: 29%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2gsb chain A

3D model

Region: 1400 - 1505
Aligned: 100
Modelled: 106
Confidence: 99.8%
Identity: 30%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2

PDB 2hmh chain A

3D model

Region: 1404 - 1505
Aligned: 102
Modelled: 102
Confidence: 99.8%
Identity: 24%
PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.

Phyre2

PDB 2eob chain A

3D model

Region: 1397 - 1509
Aligned: 106
Modelled: 113
Confidence: 99.8%
Identity: 28%
PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2

Phyre2

PDB 3gqi chain B

3D model

Region: 1396 - 1510
Aligned: 107
Modelled: 111
Confidence: 99.8%
Identity: 28%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 2kk6 chain A

3D model

Region: 1404 - 1505
Aligned: 97
Modelled: 100
Confidence: 99.8%
Identity: 33%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d

Phyre2

PDB 1pic chain A

3D model

Region: 1404 - 1508
Aligned: 103
Modelled: 105
Confidence: 99.8%
Identity: 26%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1qad chain A

3D model

Region: 1402 - 1507
Aligned: 101
Modelled: 106
Confidence: 99.8%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2vif chain A

3D model

Region: 1405 - 1505
Aligned: 101
Modelled: 101
Confidence: 99.8%
Identity: 35%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 2crh chain A

3D model

Region: 1405 - 1505
Aligned: 99
Modelled: 101
Confidence: 99.8%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 3c7i chain A domain 1

3D model

Region: 1405 - 1505
Aligned: 99
Modelled: 101
Confidence: 99.8%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1a81 chain E domain 2

3D model

Region: 1403 - 1505
Aligned: 97
Modelled: 102
Confidence: 99.8%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2dlz chain A

3D model

Region: 1401 - 1505
Aligned: 103
Modelled: 105
Confidence: 99.8%
Identity: 17%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 2lqn chain A

3D model

Region: 1404 - 1502
Aligned: 97
Modelled: 97
Confidence: 99.8%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2vpd chain A

3D model

Region: 3 - 61
Aligned: 54
Modelled: 54
Confidence: 95.4%
Identity: 28%
PDB header:gene regulation
Chain: A: PDB Molecule:pygopus homolog 1;
PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex

Phyre2

PDB 3lqi chain A

3D model

Region: 2 - 61
Aligned: 55
Modelled: 55
Confidence: 94.7%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:mll1 phd3-bromo;
PDBTitle: crystal structure of mll1 phd3-bromo complexed with h3(1-9)k4me22 peptide

Phyre2

PDB 2kyu chain A

3D model

Region: 1 - 64
Aligned: 59
Modelled: 59
Confidence: 94.7%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:histone-lysine n-methyltransferase mll;
PDBTitle: the solution structure of the phd3 finger of mll

Phyre2

PDB 2xb1 chain A

3D model

Region: 3 - 61
Aligned: 54
Modelled: 54
Confidence: 94.2%
Identity: 28%
PDB header:transcription
Chain: A: PDB Molecule:pygopus homolog 2, b-cell cll/lymphoma 9-like protein;
PDBTitle: crystal structure of the human pygo2 phd finger in complex with the2 b9l hd1 domain

Phyre2

PDB 1zvf chain A domain 1

3D model

Region: 8 - 79
Aligned: 64
Modelled: 64
Confidence: 51.7%
Identity: 23%
Fold: Double-stranded beta-helix
Superfamily: RmlC-like cupins
Family: 3-hydroxyanthranilic acid dioxygenase-like

Phyre2
1

c2eo6A_
2

c2hdxB_
3

c2eo3A_
4

c3hizB_
5

d1mila_
6

d2shpa2
7

d1fhsa_
8

c2gsbA_
9

c2hmhA_
10

c2eobA_
11

c3gqiB_
12

c2kk6A_
13

d1pica_
14

d1qada_
15

c2vifA_
16

c2crhA_
17

d3c7ia1
18

d1a81e2
19

c2dlzA_
20

c2lqnA_
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c2vpdA_
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c3lqiA_
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c2kyuA_
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c2xb1A_
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d1zvfa1
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2eo6A_



99.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
2c2hdxB_



99.8 27 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
3c2eo3A_



99.8 27 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
4c3hizB_



99.8 29 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
5d1mila_



99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
6d2shpa2



99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
7d1fhsa_



99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
8c2gsbA_



99.8 30 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
9c2hmhA_



99.8 24 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
10c2eobA_



99.8 28 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
11c3gqiB_



99.8 28 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
12c2kk6A_



99.8 33 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
13d1pica_



99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
14d1qada_



99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
15c2vifA_



99.8 35 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
16c2crhA_



99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
17d3c7ia1



99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
18d1a81e2



99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
19c2dlzA_



99.8 17 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
20c2lqnA_



99.8 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
21c1x6cA_



not modelled 99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
22c2c9wA_



not modelled 99.8 27 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
23d1r1qa_



not modelled 99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
24d1ayaa_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
25d1luia_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
26c2ci8A_



not modelled 99.7 36 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
27d2shpa3



not modelled 99.7 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
28c2dcrA_



not modelled 99.7 34 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
29d2oq1a1



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1k9aa2



not modelled 99.7 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31c2dlyA_



not modelled 99.7 33 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
32c2izvA_



not modelled 99.7 19 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
33c2lctA_



not modelled 99.7 26 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
34d1fu6a_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35d1csya_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36c2fo0A_



not modelled 99.7 33 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
37d1jwoa_



not modelled 99.7 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38c1k9aB_



not modelled 99.7 27 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
39d1lkka_



not modelled 99.7 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40d2eyva1



not modelled 99.7 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41c1ka6A_



not modelled 99.7 27 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
42c2knoA_



not modelled 99.7 29 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
43c2y3aB_



not modelled 99.7 27 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
44d1a81a1



not modelled 99.7 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45d1opka2



not modelled 99.7 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
46d2izva2



not modelled 99.7 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d1a81e1



not modelled 99.7 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d2oq1a2



not modelled 99.7 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49c2oq1A_



not modelled 99.7 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
50d1a81a2



not modelled 99.7 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51c2shpA_



not modelled 99.7 26 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
52c2el8A_



not modelled 99.7 16 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
53c2ekxA_



not modelled 99.7 31 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
54d1d4ta_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d1blja_



not modelled 99.7 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56d1rjaa_



not modelled 99.7 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57d2cs0a1



not modelled 99.7 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58d2c9wa2



not modelled 99.7 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59d1nrva_



not modelled 99.7 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d1g83a2



not modelled 99.7 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c2ysxA_



not modelled 99.7 34 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
62c2ablA_



not modelled 99.7 32 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
63d2fcia1



not modelled 99.7 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64c2ge9A_



not modelled 99.7 32 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
65d1f2fa_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66d1i3za_



not modelled 99.7 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67d1qcfa2



not modelled 99.7 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68d1jyra_



not modelled 99.7 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2augB_



not modelled 99.7 25 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
70d1bkla_



not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d1xa6a2



not modelled 99.7 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72c1x27F_



not modelled 99.7 29 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
73c3mazA_



not modelled 99.7 19 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
74c1y57A_



not modelled 99.7 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
75d1o48a_



not modelled 99.7 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76c2h8hA_



not modelled 99.7 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
77c1oplA_



not modelled 99.6 33 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
78d1rpya_



not modelled 99.6 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79c2b3oA_



not modelled 99.6 25 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
80c1rqqC_



not modelled 99.6 29 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
81c3nhnA_



not modelled 99.6 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
82d1cwea_



not modelled 99.6 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83d2qmsa1



not modelled 99.6 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84c2ozoA_



not modelled 99.6 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
85c1a81E_



not modelled 99.6 21 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
86c3gxxB_



not modelled 99.6 21 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
87c2dm0A_



not modelled 99.6 33 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
88c2eyyA_



not modelled 99.6 27 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
89c4fl2A_



not modelled 99.6 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
90c2c0iA_



not modelled 99.6 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
91c2cr4A_



not modelled 99.6 17 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
92c2dvjA_



not modelled 99.6 30 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
93c2eyzA_



not modelled 99.6 26 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
94c3ps5A_



not modelled 99.6 28 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
95c1g83A_



not modelled 99.6 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
96c3qwxX_



not modelled 99.5 29 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
97c3qwyA_



not modelled 99.5 29 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
98d1uura3



not modelled 99.4 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
99c3or8A_



not modelled 99.4 23 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
100c1xa6A_



not modelled 99.3 19 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
101c2xp1A_



not modelled 99.3 28 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
102c2dx0B_



not modelled 99.3 33 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
103d1bf5a3



not modelled 99.2 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1bg1a3



not modelled 99.1 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105c3cblA_



not modelled 98.8 40 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
106c1yvlB_



not modelled 97.5 29 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
107c1bf5A_



not modelled 97.3 28 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
108c1uusA_



not modelled 97.3 24 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
109c2cblA_



not modelled 96.8 22 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
110c3bunB_



not modelled 96.7 22 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
111c1y1uA_



not modelled 96.3 23 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducer and activator of transcription 5a;
PDBTitle: structure of unphosphorylated stat5a
112c1bg1A_



not modelled 95.9 26 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
113c2vpdA_



95.4 28 PDB header:gene regulation
Chain: A: PDB Molecule:pygopus homolog 1;
PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex
114c3lqiA_



94.7 24 PDB header:transferase
Chain: A: PDB Molecule:mll1 phd3-bromo;
PDBTitle: crystal structure of mll1 phd3-bromo complexed with h3(1-9)k4me22 peptide
115c2kyuA_



94.7 20 PDB header:transferase
Chain: A: PDB Molecule:histone-lysine n-methyltransferase mll;
PDBTitle: the solution structure of the phd3 finger of mll
116c2xb1A_



94.2 28 PDB header:transcription
Chain: A: PDB Molecule:pygopus homolog 2, b-cell cll/lymphoma 9-like protein;
PDBTitle: crystal structure of the human pygo2 phd finger in complex with the2 b9l hd1 domain
117c3cwgA_



not modelled 93.0 30 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
118d1wepa_



not modelled 92.1 31 Fold:FYVE/PHD zinc finger
Superfamily:FYVE/PHD zinc finger
Family:PHD domain
119d1weva_



not modelled 89.5 26 Fold:FYVE/PHD zinc finger
Superfamily:FYVE/PHD zinc finger
Family:PHD domain
120c2f6nA_



not modelled 88.0 22 PDB header:transcription
Chain: A: PDB Molecule:bromodomain phd finger transcription factor;
PDBTitle: crystal structure of phd finger-linker-bromodomain fragment2 of human bptf in the free form

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