Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ95PX0
DateSat Apr 13 13:19:58 BST 2013
Unique Job ID957911be8e771a01

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:60.005 Y:39.744 Z:35.880
Model (left) based on template c2fo0A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
Confidence and coverage
Confidence:100.0% Coverage: 59%
168 residues ( 59% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
267 residues ( 93%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSSKTKAVVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEV
Secondary structure 

































SS confidence 



























































Disorder  ?????











??
??




































?
Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  EASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEIQVVVALYSFDASSSEEL
Secondary structure 






















































SS confidence 



























































Disorder 

?????????????????????????????????????????












??

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   .........130.........140.........150.........160.........170.........180
Sequence  SFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVVVNDSSSSKASHQDFAPQYS
Secondary structure 






































SS confidence 



























































Disorder 
















??





?
?































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   .........190.........200.........210.........220.........230.........240
Sequence  GNGEIPMEQQPWYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIERNKHFK
Secondary structure 
































SS confidence 



























































Disorder 












?????









































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   .........250.........260.........270.........280......
Sequence  VQNVDGLLKIGNRTFVDMNALINHYTTSPIFSSPTEKLFLTGPLPK
Secondary structure 























SS confidence 













































Disorder 





























?

??





?????
Disorder confidence 













































 

Confidence Key
High(9)                    Low (0)
?Disordered ( 24%)
Alpha helix ( 7%)
Beta strand ( 29%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2fo0 chain A

3D model

Region: 90 - 286
Aligned: 168
Modelled: 174
Confidence: 100.0%
Identity: 40%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 1k9a chain B

3D model

Region: 99 - 286
Aligned: 166
Modelled: 171
Confidence: 100.0%
Identity: 32%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

PDB 2abl chain A

3D model

Region: 98 - 285
Aligned: 159
Modelled: 165
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 1opl chain A

3D model

Region: 102 - 286
Aligned: 156
Modelled: 162
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2

PDB 1y57 chain A

3D model

Region: 103 - 286
Aligned: 155
Modelled: 161
Confidence: 100.0%
Identity: 40%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor

Phyre2

PDB 3nhn chain A

3D model

Region: 105 - 284
Aligned: 151
Modelled: 157
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region

Phyre2

PDB 1x27 chain F

3D model

Region: 105 - 285
Aligned: 152
Modelled: 158
Confidence: 100.0%
Identity: 37%
PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas

Phyre2

PDB 2h8h chain A

3D model

Region: 105 - 286
Aligned: 153
Modelled: 159
Confidence: 100.0%
Identity: 40%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor

Phyre2

PDB 2c0i chain A

3D model

Region: 103 - 286
Aligned: 154
Modelled: 161
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983

Phyre2

PDB 1g83 chain A

3D model

Region: 104 - 283
Aligned: 152
Modelled: 157
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2

Phyre2

PDB 2lqn chain A

3D model

Region: 2 - 170
Aligned: 166
Modelled: 169
Confidence: 100.0%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 1gri chain A

3D model

Region: 6 - 164
Aligned: 150
Modelled: 159
Confidence: 100.0%
Identity: 27%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2l3s chain A

3D model

Region: 7 - 162
Aligned: 153
Modelled: 156
Confidence: 100.0%
Identity: 18%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 2eyz chain A

3D model

Region: 3 - 167
Aligned: 162
Modelled: 165
Confidence: 100.0%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 1ng2 chain A

3D model

Region: 6 - 186
Aligned: 149
Modelled: 153
Confidence: 100.0%
Identity: 26%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 2b3o chain A

3D model

Region: 106 - 285
Aligned: 177
Modelled: 180
Confidence: 100.0%
Identity: 23%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2eo3 chain A

3D model

Region: 146 - 286
Aligned: 109
Modelled: 109
Confidence: 100.0%
Identity: 38%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 3ps5 chain A

3D model

Region: 106 - 285
Aligned: 177
Modelled: 180
Confidence: 100.0%
Identity: 22%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 1ov3 chain A

3D model

Region: 6 - 160
Aligned: 123
Modelled: 127
Confidence: 100.0%
Identity: 28%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 2shp chain A

3D model

Region: 106 - 285
Aligned: 177
Modelled: 180
Confidence: 100.0%
Identity: 23%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2
1

c2fo0A_
2

c1k9aB_
3

c2ablA_
4

c1oplA_
5

c1y57A_
6

c3nhnA_
7

c1x27F_
8

c2h8hA_
9

c2c0iA_
10

c1g83A_
11

c2lqnA_
12

c1griA_
13

c2l3sA_
14

c2eyzA_
15

c1ng2A_
16

c2b3oA_
17

c2eo3A_
18

c3ps5A_
19

c1ov3A_
20

c2shpA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2fo0A_



100.0 40 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
2c1k9aB_



100.0 32 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
3c2ablA_



100.0 41 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
4c1oplA_



100.0 42 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
5c1y57A_



100.0 40 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
6c3nhnA_



100.0 38 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
7c1x27F_



100.0 37 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
8c2h8hA_



100.0 40 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
9c2c0iA_



100.0 41 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
10c1g83A_



100.0 37 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
11c2lqnA_



100.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
12c1griA_



100.0 27 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
13c2l3sA_



100.0 18 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
14c2eyzA_



100.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
15c1ng2A_



100.0 26 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
16c2b3oA_



100.0 23 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
17c2eo3A_



100.0 38 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
18c3ps5A_



100.0 22 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
19c1ov3A_



100.0 28 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
20c2shpA_



100.0 23 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
21c2eo6A_



not modelled 100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
22c3hizB_



not modelled 99.9 34 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
23c2hdxB_



not modelled 99.9 27 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
24c2kk6A_



not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
25c2ci8A_



not modelled 99.9 48 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
26d3c7ia1



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
27c2crhA_



not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
28c2dcrA_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
29c2gsbA_



not modelled 99.9 33 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
30c2vifA_



not modelled 99.9 32 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
31d2shpa2



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
32d1fhsa_



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
33c2dlzA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
34d2izva2



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35d2eyva1



not modelled 99.9 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36d1mila_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37c2dlyA_



not modelled 99.9 33 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
38c1x6cA_



not modelled 99.9 32 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
39d1jwoa_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40c2c9wA_



not modelled 99.9 31 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
41d2oq1a1



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d1rjaa_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43c2y3aB_



not modelled 99.9 25 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
44c2eobA_



not modelled 99.9 28 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
45c2oq1A_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
46c2hmhA_



not modelled 99.9 22 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
47d1pica_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d1a81e1



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49d1opka2



not modelled 99.9 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d1a81a2



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51c2izvA_



not modelled 99.9 27 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
52d2oq1a2



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53d1nrva_



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54c2lctA_



not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
55d1fu6a_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56d1k9aa2



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57c1a81E_



not modelled 99.9 18 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
58d1a81e2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59c2augB_



not modelled 99.9 33 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
60d1r1qa_



not modelled 99.9 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c3gqiB_



not modelled 99.9 25 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
62c1ka6A_



not modelled 99.9 29 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
63d1ayaa_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64d1blja_



not modelled 99.9 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65d1a81a1



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66c2ozoA_



not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
67d1d4ta_



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68d2fcia1



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69d1csya_



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
70d1jyra_



not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d2shpa3



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72c2ysxA_



not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
73d1i3za_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74d1qada_



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75d2cs0a1



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1lkka_



not modelled 99.9 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d1o48a_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c4fl2A_



not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
79d2qmsa1



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80d2c9wa2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2ge9A_



not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
82d1qcfa2



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83c2el8A_



not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
84c2knoA_



not modelled 99.9 26 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
85d1f2fa_



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86d1bkla_



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87d1xa6a2



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88d1g83a2



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89d1rpya_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
90c1rqqC_



not modelled 99.9 28 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
91c2ekxA_



not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
92c2cr4A_



not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
93c3mazA_



not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
94d1luia_



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c2dm0A_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
96c2dvjA_



not modelled 99.8 36 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
97d1cwea_



not modelled 99.8 41 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98c3qwxX_



not modelled 99.8 36 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
99c3gxxB_



not modelled 99.8 25 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
100c3qwyA_



not modelled 99.8 36 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
101c2eyyA_



not modelled 99.8 35 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
102c2dybA_



not modelled 99.8 15 PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)
103c2dx0B_



not modelled 99.8 34 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
104c2yt6A_



not modelled 99.8 34 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
105c1mv3A_



not modelled 99.7 19 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
106d1udla_



not modelled 99.7 39 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
107d1ng2a2



not modelled 99.7 23 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
108c3or8A_



not modelled 99.7 24 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
109c1wx6A_



not modelled 99.7 35 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:cytoplasmic protein nck2;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck2
110c2xp1A_



not modelled 99.7 17 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
111c2yuoA_



not modelled 99.7 28 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
112c2kymA_



not modelled 99.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide
113c2yunA_



not modelled 99.7 35 PDB header:protein transport
Chain: A: PDB Molecule:nostrin;
PDBTitle: solution structure of the sh3 domain of human nostrin
114c1xa6A_



not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
115c3jv3A_



not modelled 99.7 31 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l
116c2dx1A_



not modelled 99.7 28 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
117c3nmzD_



not modelled 99.7 27 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
118c1x2qA_



not modelled 99.7 26 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
119d1k4us_



not modelled 99.7 30 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
120c2ekhA_



not modelled 99.7 25 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structures of the sh3 domain of human kiaa0418

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Transmembrane helix prediction 

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