Phyre 2 Results for A0JP43

Email	l.a.kelley@imperial.ac.uk
Description	A0JP43
Date	Tue Jul 30 13:08:59 BST 2013
Unique Job ID	efd0ea767581ce5d
Sequence	MLMQVEKKKL ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:39.348 Y:43.384 Z:40.004

Model (left) based on template c3j1uA_

Top template information

PDB header:motor protein/structural protein
Chain: A: PDB Molecule:cytoplasmic dynein 1 heavy chain 1, seryl t-rna synthetase
PDBTitle: low affinity dynein microtubule binding domain - tubulin complex

Confidence and coverage

Confidence:

98.7%

Coverage:

119 residues ( 8% of your sequence) have been modelled with 98.7% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

665 residues ( 47%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M L M Q V E K K K L L S Q A D I P T K F D P I N Y L G E Y L M R H N T H Y I K D P G V S G Y Q R V M K E I T E E L K T H

Secondary structure

SS confidence

Disorder ? ? ? ?
? ?
? ? ? ?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence V P D T I N N R I S K M K E K V K E K R E Q R E Y I S T V K V K V A G M R K Q A L E E Q F N E W V L N P K G M I P I V V

Secondary structure

SS confidence

Disorder ?
? ? ?
?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence Y I S S Y I T D L K S E V F E E F L K H L C H S A E E F R E I I L T D M R R Q M F A E L F L Q C D S G K V M A L D R Q R

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence T L A L L E A F Y D Q C S S T T R S L L R N P R Q W P F V E F E E I E L I E F W G D M D I K K H I Y E D F D A L L L K M

Secondary structure

SS confidence

Disorder
? ?
? ? ? ?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence N M L V A E K L A G K L A E N K D L P Q Q Q R D Q E L S S D S T T E P E T A T Q L T S Q Q R S R R V S L T G Q G Q G K G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence P R K T S A S K Q G A S R G S V A E Q G S R R S S G V N Q T Q Q R G S V A E Q G S R R S S A V E Q T Q Q R G S V A E Q G

Secondary structure

SS confidence

Disorder
? ?
? ? ?
? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence S R R S S T V E Q T R Q R G S V A E Q G S R R S S T V E Q T Q R R G S V A E Q G S R R S S G V N Q T Q Q R G S V A E Q G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence S R R S S A V E Q T Q Q R G S V A E Q G S R R S S A M E Q E P Q T A Q D P N S D S L P E Q E S H R G S I T E G S H R G S

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence I S E P G Q R R A S V T G Q R R K S S V D D S G S A G S R R G S G T D Q G Q H R G S V G Q R K G S G E R K M S A S E Y G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence P H Q E S I T E E P L T A S E P G P Q I D T I Q E L D E D S T P Q L E D D S A L K E S K T S E L T K I E T Q E E K P L L

Secondary structure

SS confidence

Disorder ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?
? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence L I N E E Q V P R D S K Q P E V P T S S K K E R P S G S P K K G R L S G T S K R D S Q K D K A C E P K P Q H V E G K K W

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence S G E F L I C D W K I K H V K S E E E E Q A K L I C D D T R F T D L H A T I R N F Q T Y K G I K G R S A F N G V S L D L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence L Q F V Q L L E T F V G E D T S F S L S K D L A S F F Q K N Y S E T K Q E K I K A L E Q A R Q N S S R I R R R I L L Q A

Secondary structure

SS confidence

Disorder
?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence I F E K W D N D G S G F L D L N E V D D L L Y T Y K E G M E R E S M K K A K L H I N F P E P S P G H E V K L S S K Q F Q

Secondary structure

SS confidence

Disorder
?
? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence R Y I E L V V S E L R G N E D E V L E S V V E F L M G S L E R S H V E G L R N C A R R K W L H Q I Q Y A A E T S G V S L

Secondary structure

SS confidence

Disorder
?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence E P V Y T E T F R V L T Q D A E A H G N K K I S A H I S L L E E N V F L P E R G H V L L R N V A C T L D D A P F V L N K

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence V L Y R D M K G I S F T V V D E G K P I H V P Q V Q H H G N I F F W N S F R S K N E Y N G S F L A L P L Q D A Y M R I F

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence G V L A V D T L R D P H E I N I F L P H E I K F Y Q G V A N A F S T A Y H H V H S R E H V L H S V M T G I R W L F S V T

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S G I T T I T T C F I E P S S E Q E D Y V L R N M M V T D C L G L A E I H T D P P T I T R N A C I F R D F L F K C T D T

Secondary structure

SS confidence

Disorder
?
? ? ?
?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence S E V I L A S S G G E T H I A I P L R Q R T K E A M G I L D V N I G R S R M L L Y Q E Y K D L Q K M V K M I Q N V S Y E

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence I L G E F S G E I E K T M V I E M E S A G E V K R A G I L F F R T M L Q E L Q E C L C L L D S M D F V S L L L Y E H K Y

Secondary structure

SS confidence

Disorder
?
?
? ?
? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence H V D S I L Q D I T L Q E V E A N V A L V H D V L K G V I L F S Q R E K D S L S D L E E W E K W K F H I N K Y L V E E I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence C V L D P T A S N V E V N V E L V T S Y I Q A H S R T E V W N F R N I V I E L L Y H W I N I C L T L I E L N M R Q D V S

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . .

Sequence I I P P L P K K S A T S I Y A I S S E R S I R E K L

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 38%)

Alpha helix ( 75%)

Beta strand ( 2%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3j1u chain A

Region: 1234 - 1376
Aligned: 119
Modelled: 125
Confidence: 98.7%
Identity: 14%
PDB header:motor protein/structural protein
Chain: A: PDB Molecule:cytoplasmic dynein 1 heavy chain 1, seryl t-rna synthetase
PDBTitle: low affinity dynein microtubule binding domain - tubulin complex

Phyre2

PDB 2rr7 chain A

Region: 1234 - 1376
Aligned: 124
Modelled: 125
Confidence: 98.5%
Identity: 14%
PDB header:motor protein
Chain: A: PDB Molecule:dynein heavy chain 9;
PDBTitle: microtubule binding domain of dynein-c

Phyre2

PDB 3err chain B

Region: 1234 - 1377
Aligned: 120
Modelled: 126
Confidence: 98.3%
Identity: 13%
PDB header:ligase
Chain: B: PDB Molecule:fusion protein of microtubule binding domain from
PDBTitle: microtubule binding domain from mouse cytoplasmic dynein as2 a fusion with seryl-trna synthetase

Phyre2

PDB 3ibj chain B

Region: 967 - 1171
Aligned: 178
Modelled: 184
Confidence: 98.0%
Identity: 12%
PDB header:hydrolase
Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase;
PDBTitle: x-ray structure of pde2a

Phyre2

PDB 3mf0 chain A

Region: 854 - 1067
Aligned: 191
Modelled: 208
Confidence: 97.8%
Identity: 10%
PDB header:hydrolase
Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase;
PDBTitle: crystal structure of pde5a gaf domain (89-518)

Phyre2

PDB 3vkh chain A

Region: 1173 - 1368
Aligned: 172
Modelled: 178
Confidence: 97.7%
Identity: 16%
PDB header:motor protein
Chain: A: PDB Molecule:dynein heavy chain, cytoplasmic;
PDBTitle: x-ray structure of a functional full-length dynein motor domain

Phyre2

PDB 1mc0 chain A

Region: 854 - 1067
Aligned: 198
Modelled: 214
Confidence: 97.7%
Identity: 12%
PDB header:hydrolase
Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a;
PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains

Phyre2

PDB 3o4x chain E

Region: 9 - 187
Aligned: 178
Modelled: 179
Confidence: 97.3%
Identity: 15%
PDB header:protein binding
Chain: E: PDB Molecule:protein diaphanous homolog 1;
PDBTitle: crystal structure of complex between amino and carboxy terminal2 fragments of mdia1

Phyre2

PDB 1ux5 chain A

Region: 9 - 165
Aligned: 156
Modelled: 157
Confidence: 97.2%
Identity: 13%
Fold: Formin homology 2 domain (FH2 domain)
Superfamily: Formin homology 2 domain (FH2 domain)
Family: Formin homology 2 domain (FH2 domain)

Phyre2

PDB 3o4x chain F

Region: 9 - 193
Aligned: 184
Modelled: 185
Confidence: 97.2%
Identity: 14%
PDB header:protein binding
Chain: F: PDB Molecule:protein diaphanous homolog 1;
PDBTitle: crystal structure of complex between amino and carboxy terminal2 fragments of mdia1

Phyre2

PDB 1y64 chain B

Region: 9 - 167
Aligned: 158
Modelled: 159
Confidence: 96.9%
Identity: 13%
PDB header:structural protein
Chain: B: PDB Molecule:bni1 protein;
PDBTitle: bni1p formin homology 2 domain complexed with atp-actin

Phyre2

PDB 2lb5 chain A

Region: 935 - 1062
Aligned: 123
Modelled: 128
Confidence: 96.9%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: refined structural basis for the photoconversion of a phytochrome to2 the activated far-red light-absorbing form

Phyre2

PDB 1f5m chain A

Region: 967 - 1055
Aligned: 79
Modelled: 85
Confidence: 96.8%
Identity: 20%
Fold: Profilin-like
Superfamily: GAF domain-like
Family: GAF domain

Phyre2

PDB 1v9d chain A

Region: 9 - 179
Aligned: 170
Modelled: 171
Confidence: 96.7%
Identity: 16%
Fold: Formin homology 2 domain (FH2 domain)
Superfamily: Formin homology 2 domain (FH2 domain)
Family: Formin homology 2 domain (FH2 domain)

Phyre2

PDB 1vhm chain B

Region: 968 - 1056
Aligned: 78
Modelled: 89
Confidence: 96.7%
Identity: 18%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein yebr;
PDBTitle: crystal structure of an hypothetical protein

Phyre2

PDB 3oov chain A

Region: 935 - 1063
Aligned: 125
Modelled: 128
Confidence: 96.7%
Identity: 14%
PDB header:signaling protein
Chain: A: PDB Molecule:methyl-accepting chemotaxis protein, putative;
PDBTitle: crystal structure of a methyl-accepting chemotaxis protein, residues2 122 to 287

Phyre2

PDB 3p01 chain C

Region: 871 - 1058
Aligned: 163
Modelled: 188
Confidence: 96.7%
Identity: 13%
PDB header:signaling protein
Chain: C: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120

Phyre2

PDB 4fof chain A

Region: 935 - 1067
Aligned: 128
Modelled: 133
Confidence: 96.6%
Identity: 11%
PDB header:signaling protein
Chain: A: PDB Molecule:methyl-accepting chemotaxis protein;
PDBTitle: crystal structure of the blue-light absorbing form of the2 thermosynechococcus elongatus pixj gaf-domain

Phyre2

PDB 1vhm chain A

Region: 968 - 1056
Aligned: 78
Modelled: 89
Confidence: 96.4%
Identity: 19%
Fold: Profilin-like
Superfamily: GAF domain-like
Family: GAF domain

Phyre2

PDB 2vjw chain A

Region: 934 - 1063
Aligned: 112
Modelled: 130
Confidence: 96.4%
Identity: 19%
PDB header:hydrolase
Chain: A: PDB Molecule:gaf family protein;
PDBTitle: crystal structure of the second gaf domain of devs from2 mycobacterium smegmatis

Phyre2

PDB 3hpb chain A

Region: 1361 - 1396
Aligned: 31
Modelled: 31
Confidence: 54.8%
Identity: 29%
PDB header:protein transport
Chain: A: PDB Molecule:snx5 protein;
PDBTitle: crystal structure of snx5-px domain in p212121 space group

Phyre2

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	L	M	Q	V	E	K	K	K	L	L	S	Q	A	D	I	P	T	K	F	D	P	I	N	Y	L	G	E	Y	L	M	R	H	N	T	H	Y	I	K	D	P	G	V	S	G	Y	Q	R	V	M	K	E	I	T	E	E	L	K	T	H
Secondary structure
SS confidence
Disorder	?	?	?	?		?	?					?	?	?	?																								?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	V	P	D	T	I	N	N	R	I	S	K	M	K	E	K	V	K	E	K	R	E	Q	R	E	Y	I	S	T	V	K	V	K	V	A	G	M	R	K	Q	A	L	E	E	Q	F	N	E	W	V	L	N	P	K	G	M	I	P	I	V	V
Secondary structure
SS confidence
Disorder	?		?	?	?																																																?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	Y	I	S	S	Y	I	T	D	L	K	S	E	V	F	E	E	F	L	K	H	L	C	H	S	A	E	E	F	R	E	I	I	L	T	D	M	R	R	Q	M	F	A	E	L	F	L	Q	C	D	S	G	K	V	M	A	L	D	R	Q	R
Secondary structure
SS confidence
Disorder								?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	T	L	A	L	L	E	A	F	Y	D	Q	C	S	S	T	T	R	S	L	L	R	N	P	R	Q	W	P	F	V	E	F	E	E	I	E	L	I	E	F	W	G	D	M	D	I	K	K	H	I	Y	E	D	F	D	A	L	L	L	K	M
Secondary structure
SS confidence
Disorder												?	?																?	?	?	?		?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	N	M	L	V	A	E	K	L	A	G	K	L	A	E	N	K	D	L	P	Q	Q	Q	R	D	Q	E	L	S	S	D	S	T	T	E	P	E	T	A	T	Q	L	T	S	Q	Q	R	S	R	R	V	S	L	T	G	Q	G	Q	G	K	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	P	R	K	T	S	A	S	K	Q	G	A	S	R	G	S	V	A	E	Q	G	S	R	R	S	S	G	V	N	Q	T	Q	Q	R	G	S	V	A	E	Q	G	S	R	R	S	S	A	V	E	Q	T	Q	Q	R	G	S	V	A	E	Q	G
Secondary structure
SS confidence
Disorder				?	?								?	?	?			?	?	?	?	?	?	?	?	?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	S	R	R	S	S	T	V	E	Q	T	R	Q	R	G	S	V	A	E	Q	G	S	R	R	S	S	T	V	E	Q	T	Q	R	R	G	S	V	A	E	Q	G	S	R	R	S	S	G	V	N	Q	T	Q	Q	R	G	S	V	A	E	Q	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?				?	?	?	?	?									?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?					?	?	?	?	?	?		?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	S	R	R	S	S	A	V	E	Q	T	Q	Q	R	G	S	V	A	E	Q	G	S	R	R	S	S	A	M	E	Q	E	P	Q	T	A	Q	D	P	N	S	D	S	L	P	E	Q	E	S	H	R	G	S	I	T	E	G	S	H	R	G	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?																	?	?	?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	I	S	E	P	G	Q	R	R	A	S	V	T	G	Q	R	R	K	S	S	V	D	D	S	G	S	A	G	S	R	R	G	S	G	T	D	Q	G	Q	H	R	G	S	V	G	Q	R	K	G	S	G	E	R	K	M	S	A	S	E	Y	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?						?	?	?	?						?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	P	H	Q	E	S	I	T	E	E	P	L	T	A	S	E	P	G	P	Q	I	D	T	I	Q	E	L	D	E	D	S	T	P	Q	L	E	D	D	S	A	L	K	E	S	K	T	S	E	L	T	K	I	E	T	Q	E	E	K	P	L	L
Secondary structure
SS confidence
Disorder	?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?							?	?	?	?	?	?	?	?		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	L	I	N	E	E	Q	V	P	R	D	S	K	Q	P	E	V	P	T	S	S	K	K	E	R	P	S	G	S	P	K	K	G	R	L	S	G	T	S	K	R	D	S	Q	K	D	K	A	C	E	P	K	P	Q	H	V	E	G	K	K	W
Secondary structure
SS confidence
Disorder	?	?	?			?	?	?	?	?	?	?	?	?	?			?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	S	G	E	F	L	I	C	D	W	K	I	K	H	V	K	S	E	E	E	E	Q	A	K	L	I	C	D	D	T	R	F	T	D	L	H	A	T	I	R	N	F	Q	T	Y	K	G	I	K	G	R	S	A	F	N	G	V	S	L	D	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	L	Q	F	V	Q	L	L	E	T	F	V	G	E	D	T	S	F	S	L	S	K	D	L	A	S	F	F	Q	K	N	Y	S	E	T	K	Q	E	K	I	K	A	L	E	Q	A	R	Q	N	S	S	R	I	R	R	R	I	L	L	Q	A
Secondary structure
SS confidence
Disorder															?																?	?	?	?									?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	I	F	E	K	W	D	N	D	G	S	G	F	L	D	L	N	E	V	D	D	L	L	Y	T	Y	K	E	G	M	E	R	E	S	M	K	K	A	K	L	H	I	N	F	P	E	P	S	P	G	H	E	V	K	L	S	S	K	Q	F	Q
Secondary structure
SS confidence
Disorder										?		?	?															?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	R	Y	I	E	L	V	V	S	E	L	R	G	N	E	D	E	V	L	E	S	V	V	E	F	L	M	G	S	L	E	R	S	H	V	E	G	L	R	N	C	A	R	R	K	W	L	H	Q	I	Q	Y	A	A	E	T	S	G	V	S	L
Secondary structure
SS confidence
Disorder														?																																								?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	E	P	V	Y	T	E	T	F	R	V	L	T	Q	D	A	E	A	H	G	N	K	K	I	S	A	H	I	S	L	L	E	E	N	V	F	L	P	E	R	G	H	V	L	L	R	N	V	A	C	T	L	D	D	A	P	F	V	L	N	K
Secondary structure
SS confidence
Disorder																	?	?	?	?													?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	V	L	Y	R	D	M	K	G	I	S	F	T	V	V	D	E	G	K	P	I	H	V	P	Q	V	Q	H	H	G	N	I	F	F	W	N	S	F	R	S	K	N	E	Y	N	G	S	F	L	A	L	P	L	Q	D	A	Y	M	R	I	F
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	G	V	L	A	V	D	T	L	R	D	P	H	E	I	N	I	F	L	P	H	E	I	K	F	Y	Q	G	V	A	N	A	F	S	T	A	Y	H	H	V	H	S	R	E	H	V	L	H	S	V	M	T	G	I	R	W	L	F	S	V	T
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	G	I	T	T	I	T	T	C	F	I	E	P	S	S	E	Q	E	D	Y	V	L	R	N	M	M	V	T	D	C	L	G	L	A	E	I	H	T	D	P	P	T	I	T	R	N	A	C	I	F	R	D	F	L	F	K	C	T	D	T
Secondary structure
SS confidence
Disorder																		?									?	?	?		?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	S	E	V	I	L	A	S	S	G	G	E	T	H	I	A	I	P	L	R	Q	R	T	K	E	A	M	G	I	L	D	V	N	I	G	R	S	R	M	L	L	Y	Q	E	Y	K	D	L	Q	K	M	V	K	M	I	Q	N	V	S	Y	E
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	I	L	G	E	F	S	G	E	I	E	K	T	M	V	I	E	M	E	S	A	G	E	V	K	R	A	G	I	L	F	F	R	T	M	L	Q	E	L	Q	E	C	L	C	L	L	D	S	M	D	F	V	S	L	L	L	Y	E	H	K	Y
Secondary structure
SS confidence
Disorder					?		?		?	?								?	?	?	?	?	?	?	?																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	H	V	D	S	I	L	Q	D	I	T	L	Q	E	V	E	A	N	V	A	L	V	H	D	V	L	K	G	V	I	L	F	S	Q	R	E	K	D	S	L	S	D	L	E	E	W	E	K	W	K	F	H	I	N	K	Y	L	V	E	E	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?	?		?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	C	V	L	D	P	T	A	S	N	V	E	V	N	V	E	L	V	T	S	Y	I	Q	A	H	S	R	T	E	V	W	N	F	R	N	I	V	I	E	L	L	Y	H	W	I	N	I	C	L	T	L	I	E	L	N	M	R	Q	D	V	S
Secondary structure
SS confidence
Disorder										?																																												?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.
Sequence	I	I	P	P	L	P	K	K	S	A	T	S	I	Y	A	I	S	S	E	R	S	I	R	E	K	L
Secondary structure
SS confidence
Disorder	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence