Phyre 2 Results for P0A8V2

Email	l.a.kelley@imperial.ac.uk
Description	P0A8V2
Date	Wed Jan 25 15:20:19 GMT 2012
Unique Job ID	d381a67183fa0e58

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3iydC_

Top template information

PDB header:transcription/dna
Chain: C: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: three-dimensional em structure of an intact activator-dependent2 transcription initiation complex

Confidence and coverage

Confidence:

100.0%

Coverage:

81%

1089 residues ( 81% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M V Y S Y T E K K R I R K D F G K R P Q V L D V P Y L L S I Q L D S F Q K F I E Q D P E G Q Y G L E A A F R S V F P I Q

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?
?
? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence S Y S G N S E L Q Y V S Y R L G E P V F D V Q E C Q I R G V T Y S A P L R V K L R L V I Y E R E A P E G T V K D I K E Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence E V Y M G E I P L M T D N G T F V I N G T E R V I V S Q L H R S P G V F F D S D K G K T H S S G K V L Y N A R I I P Y R

Secondary structure

SS confidence

Disorder
?
?
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence G S W L D F E F D P K D N L F V R I D R R R K L P A T I I L R A L N Y T T E Q I L D L F F E K V I F E I R D N K L Q M E

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence L V P E R L R G E T A S F D I E A N G K V Y V E K G R R I T A R H I R Q L E K D D V K L I E V P V E Y I A G K V V A K D

Secondary structure

SS confidence

Disorder
?
?
? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence Y I D E S T G E L I C A A N M E L S L D L L A K L S Q S G H K R I E T L F T N D L D H G P Y I S E T L R V D P T N D R L

Secondary structure

SS confidence

Disorder
? ? ?
?
?
? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence S A L V E I Y R M M R P G E P P T R E A A E S L F E N L F F S E D R Y D L S A V G R M K F N R S L L R E E I E G S G I L

Secondary structure

SS confidence

Disorder
?
? ?
?
?
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence S K D D I I D V M K K L I D I R N G K G E V D D I D H L G N R R I R S V G E M A E N Q F R V G L V R V E R A V K E R L S

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence L G D L D T L M P Q D M I N A K P I S A A V K E F F G S S Q L S Q F M D Q N N P L S E I T H K R R I S A L G P G G L T R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
?
?
?
? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence E R A G F E V R D V H P T H Y G R V C P I E T P E G P N I G L I N S L S V Y A Q T N E Y G F L E T P Y R K V T D G V V T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
?
? ? ?
? ?
?
? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence D E I H Y L S A I E E G N Y V I A Q A N S N L D E E G H F V E D L V T C R S K G E S S L F S R D Q V D Y M D V S T Q Q V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence V S V G A S L I P F L E H D D A N R A L M G A N M Q R Q A V P T L R A D K P L V G T G M E R A V A V D S G V T A V A K R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence G G V V Q Y V D A S R I V I K V N E D E M Y P G E A G I D I Y N L T K Y T R S N Q N T C I N Q M P C V S L G E P V E R G

Secondary structure

SS confidence

Disorder
? ?
? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence D V L A D G P S T D L G E L A L G Q N M R V A F M P W N G Y N F E D S I L V S E R V V Q E D R F T T I H I Q E L A C V S

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence R D T K L G P E E I T A D I P N V G E A A L S K L D E S G I V Y I G A E V T G G D I L V G K V T P K G E T Q L T P E E K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ?
? ? ?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence L L R A I F G E K A S D V K D S S L R V P N G V S G T V I D V Q V F T R D G V E K D K R A L E I E E M Q L K Q A K K D L

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence S E E L Q I L E A G L F S R I R A V L V A G G V E A E K L D K L P R D R W L E L G L T D E E K Q N Q L E Q L A E Q Y D E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ?
?
?
?
? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence L K H E F E K K L E A K R R K I T Q G D D L A P G V L K I V K V Y L A V K R R I Q P G D K M A G R H G N K G V I S K I N

Secondary structure

SS confidence

Disorder ? ? ?
?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence P I E D M P Y D E N G T P V D I V L N P L G V P S R M N I G Q I L E T H L G M A A K G I G D K I N A M L K Q Q Q E V A K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence L R E F I Q R A Y D L G A D V R Q K V D L S T F S D E E V M R L A E N L R K G M P I A T P V F D G A K E A E I K E L L K

Secondary structure

SS confidence

Disorder ?
?
?
?
? ?
? ? ? ?
?
?
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence L G D L P T S G Q I R L Y D G R T G E Q F E R P V T V G Y M Y M L K L N H L V D D K M H A R S T G S Y S L V T Q Q P L G

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence G K A Q F G G Q R F G E M E V W A L E A Y G A A Y T L Q E M L T V K S D D V N G R T K M Y K N I V D G N H Q M E P G M P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . .

Sequence E S F N V L L K E I R S L G I N I E L E D E

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3iyd chain C

Region: 10 - 1342
Aligned: 1089
Modelled: 1089
Confidence: 100.0%
Identity: 99%
PDB header:transcription/dna
Chain: C: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: three-dimensional em structure of an intact activator-dependent2 transcription initiation complex

Phyre2

PDB 1smy chain C

Region: 13 - 1342
Aligned: 1086
Modelled: 1115
Confidence: 100.0%
Identity: 50%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta

Phyre2

PDB 1ynj chain C domain 1

Region: 13 - 1342
Aligned: 1085
Modelled: 1115
Confidence: 100.0%
Identity: 50%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta

Phyre2

PDB 2pmz chain B

Region: 15 - 1342
Aligned: 908
Modelled: 936
Confidence: 100.0%
Identity: 31%
PDB header:translation, transferase
Chain: B: PDB Molecule:dna-directed rna polymerase subunit b;
PDBTitle: archaeal rna polymerase from sulfolobus solfataricus

Phyre2

PDB 3h0g chain N

Region: 13 - 1342
Aligned: 988
Modelled: 1004
Confidence: 100.0%
Identity: 27%
PDB header:transcription
Chain: N: PDB Molecule:dna-directed rna polymerase ii subunit rpb2;
PDBTitle: rna polymerase ii from schizosaccharomyces pombe

Phyre2

PDB 1twf chain B

Region: 10 - 1342
Aligned: 892
Modelled: 925
Confidence: 100.0%
Identity: 30%
Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase
Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase
Family: RNA-polymerase beta

Phyre2

PDB 3mlq chain D

Region: 24 - 513
Aligned: 179
Modelled: 187
Confidence: 100.0%
Identity: 54%
PDB header:transferase/transcription
Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: crystal structure of the thermus thermophilus transcription-repair2 coupling factor rna polymerase interacting domain with the thermus3 aquaticus rna polymerase beta1 domain

Phyre2

PDB 3mlq chain B

Region: 27 - 512
Aligned: 175
Modelled: 183
Confidence: 100.0%
Identity: 59%
PDB header:transferase/transcription
Chain: B: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: crystal structure of the thermus thermophilus transcription-repair2 coupling factor rna polymerase interacting domain with the thermus3 aquaticus rna polymerase beta1 domain

Phyre2

PDB 3tbi chain B

Region: 831 - 1057
Aligned: 227
Modelled: 227
Confidence: 100.0%
Identity: 100%
PDB header:transcription
Chain: B: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: crystal structure of t4 gp33 bound to e. coli rnap beta-flap domain

Phyre2

PDB 3lti chain A

Region: 152 - 443
Aligned: 273
Modelled: 292
Confidence: 100.0%
Identity: 92%
PDB header:transferase
Chain: A: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: crystal structure of the escherichia coli rna polymerase beta subunit2 beta2-betai4 domains

Phyre2

PDB 3qqc chain A

Region: 1272 - 1341
Aligned: 61
Modelled: 70
Confidence: 99.4%
Identity: 23%
PDB header:transcription
Chain: A: PDB Molecule:dna-directed rna polymerase subunit b, dna-directed rna
PDBTitle: crystal structure of archaeal spt4/5 bound to the rnap clamp domain

Phyre2

PDB 3e7h chain A

Region: 228 - 328
Aligned: 101
Modelled: 101
Confidence: 95.6%
Identity: 75%
PDB header:transferase
Chain: A: PDB Molecule:dna-directed rna polymerase subunit beta;
PDBTitle: the crystal structure of the beta subunit of the dna-2 directed rna polymerase from vibrio cholerae o1 biovar3 eltor

Phyre2

PDB 1r46 chain A domain 1

Region: 1079 - 1103
Aligned: 25
Modelled: 25
Confidence: 50.9%
Identity: 20%
Fold: Glycosyl hydrolase domain
Superfamily: Glycosyl hydrolase domain
Family: alpha-Amylases, C-terminal beta-sheet domain

Phyre2

PDB 1gjj chain A

Region: 1085 - 1206
Aligned: 70
Modelled: 64
Confidence: 50.3%
Identity: 20%
PDB header:membrane protein
Chain: A: PDB Molecule:lap2;
PDBTitle: n-terminal constant region of the nuclear envelope protein2 lap2

Phyre2

PDB 2gti chain A

Region: 1216 - 1279
Aligned: 63
Modelled: 62
Confidence: 41.6%
Identity: 14%
PDB header:viral protein
Chain: A: PDB Molecule:replicase polyprotein 1ab;
PDBTitle: mutation of mhv coronavirus non-structural protein nsp15 (f307l)

Phyre2

PDB 1n26 chain A domain 2

Region: 1068 - 1103
Aligned: 36
Modelled: 36
Confidence: 30.8%
Identity: 11%
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Fibronectin type III
Family: Fibronectin type III

Phyre2

PDB 2eyq chain A domain 5

Region: 1067 - 1085
Aligned: 19
Modelled: 19
Confidence: 28.1%
Identity: 16%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Tandem AAA-ATPase domain

Phyre2

PDB 1gm5 chain A domain 4

Region: 1067 - 1086
Aligned: 20
Modelled: 20
Confidence: 27.8%
Identity: 15%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Tandem AAA-ATPase domain

Phyre2

PDB 1y4o chain A domain 1

Region: 1071 - 1106
Aligned: 19
Modelled: 19
Confidence: 26.6%
Identity: 53%
Fold: Profilin-like
Superfamily: Roadblock/LC7 domain
Family: Roadblock/LC7 domain

Phyre2

PDB 2f3n chain A domain 1

Region: 1191 - 1221
Aligned: 31
Modelled: 31
Confidence: 25.7%
Identity: 10%
Fold: SAM domain-like
Superfamily: SAM/Pointed domain
Family: SAM (sterile alpha motif) domain

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	V	Y	S	Y	T	E	K	K	R	I	R	K	D	F	G	K	R	P	Q	V	L	D	V	P	Y	L	L	S	I	Q	L	D	S	F	Q	K	F	I	E	Q	D	P	E	G	Q	Y	G	L	E	A	A	F	R	S	V	F	P	I	Q
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?										?																								?	?	?	?	?								?					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	S	Y	S	G	N	S	E	L	Q	Y	V	S	Y	R	L	G	E	P	V	F	D	V	Q	E	C	Q	I	R	G	V	T	Y	S	A	P	L	R	V	K	L	R	L	V	I	Y	E	R	E	A	P	E	G	T	V	K	D	I	K	E	Q
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	E	V	Y	M	G	E	I	P	L	M	T	D	N	G	T	F	V	I	N	G	T	E	R	V	I	V	S	Q	L	H	R	S	P	G	V	F	F	D	S	D	K	G	K	T	H	S	S	G	K	V	L	Y	N	A	R	I	I	P	Y	R
Secondary structure
SS confidence
Disorder																											?		?		?									?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	G	S	W	L	D	F	E	F	D	P	K	D	N	L	F	V	R	I	D	R	R	R	K	L	P	A	T	I	I	L	R	A	L	N	Y	T	T	E	Q	I	L	D	L	F	F	E	K	V	I	F	E	I	R	D	N	K	L	Q	M	E
Secondary structure
SS confidence
Disorder																																																?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	L	V	P	E	R	L	R	G	E	T	A	S	F	D	I	E	A	N	G	K	V	Y	V	E	K	G	R	R	I	T	A	R	H	I	R	Q	L	E	K	D	D	V	K	L	I	E	V	P	V	E	Y	I	A	G	K	V	V	A	K	D
Secondary structure
SS confidence
Disorder																												?											?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	Y	I	D	E	S	T	G	E	L	I	C	A	A	N	M	E	L	S	L	D	L	L	A	K	L	S	Q	S	G	H	K	R	I	E	T	L	F	T	N	D	L	D	H	G	P	Y	I	S	E	T	L	R	V	D	P	T	N	D	R	L
Secondary structure
SS confidence
Disorder															?	?	?											?															?												?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	S	A	L	V	E	I	Y	R	M	M	R	P	G	E	P	P	T	R	E	A	A	E	S	L	F	E	N	L	F	F	S	E	D	R	Y	D	L	S	A	V	G	R	M	K	F	N	R	S	L	L	R	E	E	I	E	G	S	G	I	L
Secondary structure
SS confidence
Disorder													?		?	?											?							?																					?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	S	K	D	D	I	I	D	V	M	K	K	L	I	D	I	R	N	G	K	G	E	V	D	D	I	D	H	L	G	N	R	R	I	R	S	V	G	E	M	A	E	N	Q	F	R	V	G	L	V	R	V	E	R	A	V	K	E	R	L	S
Secondary structure
SS confidence
Disorder																		?							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	L	G	D	L	D	T	L	M	P	Q	D	M	I	N	A	K	P	I	S	A	A	V	K	E	F	F	G	S	S	Q	L	S	Q	F	M	D	Q	N	N	P	L	S	E	I	T	H	K	R	R	I	S	A	L	G	P	G	G	L	T	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?			?																										?		?								?	?		?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	E	R	A	G	F	E	V	R	D	V	H	P	T	H	Y	G	R	V	C	P	I	E	T	P	E	G	P	N	I	G	L	I	N	S	L	S	V	Y	A	Q	T	N	E	Y	G	F	L	E	T	P	Y	R	K	V	T	D	G	V	V	T
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																														?					?	?	?		?	?						?			?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	D	E	I	H	Y	L	S	A	I	E	E	G	N	Y	V	I	A	Q	A	N	S	N	L	D	E	E	G	H	F	V	E	D	L	V	T	C	R	S	K	G	E	S	S	L	F	S	R	D	Q	V	D	Y	M	D	V	S	T	Q	Q	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	V	S	V	G	A	S	L	I	P	F	L	E	H	D	D	A	N	R	A	L	M	G	A	N	M	Q	R	Q	A	V	P	T	L	R	A	D	K	P	L	V	G	T	G	M	E	R	A	V	A	V	D	S	G	V	T	A	V	A	K	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	G	G	V	V	Q	Y	V	D	A	S	R	I	V	I	K	V	N	E	D	E	M	Y	P	G	E	A	G	I	D	I	Y	N	L	T	K	Y	T	R	S	N	Q	N	T	C	I	N	Q	M	P	C	V	S	L	G	E	P	V	E	R	G
Secondary structure
SS confidence
Disorder																		?	?				?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	D	V	L	A	D	G	P	S	T	D	L	G	E	L	A	L	G	Q	N	M	R	V	A	F	M	P	W	N	G	Y	N	F	E	D	S	I	L	V	S	E	R	V	V	Q	E	D	R	F	T	T	I	H	I	Q	E	L	A	C	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	R	D	T	K	L	G	P	E	E	I	T	A	D	I	P	N	V	G	E	A	A	L	S	K	L	D	E	S	G	I	V	Y	I	G	A	E	V	T	G	G	D	I	L	V	G	K	V	T	P	K	G	E	T	Q	L	T	P	E	E	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?	?	?				?	?	?																														?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	L	L	R	A	I	F	G	E	K	A	S	D	V	K	D	S	S	L	R	V	P	N	G	V	S	G	T	V	I	D	V	Q	V	F	T	R	D	G	V	E	K	D	K	R	A	L	E	I	E	E	M	Q	L	K	Q	A	K	K	D	L
Secondary structure
SS confidence
Disorder																																							?	?	?	?												?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	S	E	E	L	Q	I	L	E	A	G	L	F	S	R	I	R	A	V	L	V	A	G	G	V	E	A	E	K	L	D	K	L	P	R	D	R	W	L	E	L	G	L	T	D	E	E	K	Q	N	Q	L	E	Q	L	A	E	Q	Y	D	E
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?								?			?																									?				?	?					?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	L	K	H	E	F	E	K	K	L	E	A	K	R	R	K	I	T	Q	G	D	D	L	A	P	G	V	L	K	I	V	K	V	Y	L	A	V	K	R	R	I	Q	P	G	D	K	M	A	G	R	H	G	N	K	G	V	I	S	K	I	N
Secondary structure
SS confidence
Disorder	?	?	?													?		?	?	?	?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	P	I	E	D	M	P	Y	D	E	N	G	T	P	V	D	I	V	L	N	P	L	G	V	P	S	R	M	N	I	G	Q	I	L	E	T	H	L	G	M	A	A	K	G	I	G	D	K	I	N	A	M	L	K	Q	Q	Q	E	V	A	K
Secondary structure
SS confidence
Disorder																																																						?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	L	R	E	F	I	Q	R	A	Y	D	L	G	A	D	V	R	Q	K	V	D	L	S	T	F	S	D	E	E	V	M	R	L	A	E	N	L	R	K	G	M	P	I	A	T	P	V	F	D	G	A	K	E	A	E	I	K	E	L	L	K
Secondary structure
SS confidence
Disorder	?		?		?			?		?	?		?	?	?	?							?			?		?		?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	L	G	D	L	P	T	S	G	Q	I	R	L	Y	D	G	R	T	G	E	Q	F	E	R	P	V	T	V	G	Y	M	Y	M	L	K	L	N	H	L	V	D	D	K	M	H	A	R	S	T	G	S	Y	S	L	V	T	Q	Q	P	L	G
Secondary structure
SS confidence
Disorder																																																			?					?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	G	K	A	Q	F	G	G	Q	R	F	G	E	M	E	V	W	A	L	E	A	Y	G	A	A	Y	T	L	Q	E	M	L	T	V	K	S	D	D	V	N	G	R	T	K	M	Y	K	N	I	V	D	G	N	H	Q	M	E	P	G	M	P
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?																																												?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.
Sequence	E	S	F	N	V	L	L	K	E	I	R	S	L	G	I	N	I	E	L	E	D	E
Secondary structure
SS confidence
Disorder																	?			?	?	?
Disorder confidence