Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	D	N	T	V	P	L	K	L	I	A	L	L	A	N	G	E	F	H	S	G	E	Q	L	G	E	T	L	G	M	S	R	A	A	I	N	K	H	I	Q	T	L	R	D	W	G	V	D	V	F	T	V	P	G	K	G	Y	S	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?													?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	E	P	I	Q	L	L	N	A	K	Q	I	L	G	Q	L	D	G	G	S	V	A	V	L	P	V	I	D	S	T	N	Q	Y	L	L	D	R	I	G	E	L	K	S	G	D	A	C	I	A	E	Y	Q	Q	A	G	R	G	R	R	G
Secondary structure
SS confidence
Disorder															?																																									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	K	W	F	S	P	F	G	A	N	L	Y	L	S	M	F	W	R	L	E	Q	G	P	A	A	A	I	G	L	S	L	V	I	G	I	V	M	A	E	V	L	R	K	L	G	A	D	K	V	R	V	K	W	P	N	D	L	Y	L	Q
Secondary structure
SS confidence
Disorder																						?					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	R	K	L	A	G	I	L	V	E	L	T	G	K	T	G	D	A	A	Q	I	V	I	G	A	G	I	N	M	A	M	R	R	V	E	E	S	V	V	N	Q	G	W	I	T	L	Q	E	A	G	I	N	L	D	R	N	T	L	A	A
Secondary structure
SS confidence
Disorder															?																				?	?	?	?	?	?	?	?	?		?	?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		M	L	I	R	E	L	R	A	A	L	E	L	F	E	Q	E	G	L	A	P	Y	L	S	R	W	E	K	L	D	N	F	I	N	R	P	V	K	L	I	I	G	D	K	E	I	F	G	I	S	R	G	I	D	K	Q	G	A	L	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.
Sequence		E	Q	D	G	I	I	K	P	W	M	G	G	E	I	S	L	R	S	A	E	K
Secondary structure
SS confidence
Disorder																		?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2ewn chain A Region: 3 - 320 Aligned: 318 Modelled: 318 Confidence: 100.0% Identity: 100% PDB header:ligase, transcription Chain: A: PDB Molecule:bira bifunctional protein; PDBTitle: ecoli biotin repressor with co-repressor analog Phyre2 PDB 2ej9 chain A Region: 80 - 317 Aligned: 228 Modelled: 235 Confidence: 100.0% Identity: 29% PDB header:ligase Chain: A: PDB Molecule:putative biotin ligase; PDBTitle: crystal structure of biotin protein ligase from2 methanococcus jannaschii Phyre2 PDB 2eay chain B Region: 79 - 319 Aligned: 220 Modelled: 229 Confidence: 100.0% Identity: 28% PDB header:ligase Chain: B: PDB Molecule:biotin [acetyl-coa-carboxylase] ligase; PDBTitle: crystal structure of biotin protein ligase from aquifex2 aeolicus Phyre2 PDB 2cgh chain B Region: 65 - 316 Aligned: 228 Modelled: 252 Confidence: 100.0% Identity: 32% PDB header:ligase Chain: B: PDB Molecule:biotin ligase; PDBTitle: crystal structure of biotin ligase from mycobacterium2 tuberculosis Phyre2 PDB 3bfm chain A Region: 103 - 317 Aligned: 211 Modelled: 215 Confidence: 100.0% Identity: 12% PDB header:unknown function Chain: A: PDB Molecule:biotin protein ligase-like protein of unknown function; PDBTitle: crystal structure of a biotin protein ligase-like protein of unknown2 function (tm1040_0394) from silicibacter sp. tm1040 at 1.70 a3 resolution Phyre2 PDB 2dzc chain A Region: 72 - 317 Aligned: 216 Modelled: 235 Confidence: 100.0% Identity: 28% PDB header:ligase Chain: A: PDB Molecule:biotin--[acetyl-coa-carboxylase] ligase; PDBTitle: crystal structure of biotin protein ligase from pyrococcus2 horikoshii, mutation r48a Phyre2 PDB 2zgw chain A domain 2 Region: 72 - 271 Aligned: 185 Modelled: 200 Confidence: 100.0% Identity: 26% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: Biotin holoenzyme synthetase Phyre2 PDB 1bia chain A domain 3 Region: 64 - 269 Aligned: 181 Modelled: 197 Confidence: 100.0% Identity: 96% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: Biotin holoenzyme synthetase Phyre2 PDB 1bia chain A domain 1 Region: 1 - 63 Aligned: 63 Modelled: 63 Confidence: 99.5% Identity: 100% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Biotin repressor-like Phyre2 PDB 1bia chain A domain 2 Region: 271 - 317 Aligned: 47 Modelled: 47 Confidence: 99.0% Identity: 100% Fold: SH3-like barrel Superfamily: C-terminal domain of transcriptional repressors Family: Biotin repressor (BirA) Phyre2 PDB 2qhv chain A Region: 116 - 250 Aligned: 126 Modelled: 132 Confidence: 98.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:lipoyltransferase; PDBTitle: structural basis of octanoic acid recognition by lipoate-protein2 ligase b Phyre2 PDB 2qhs chain A Region: 116 - 250 Aligned: 126 Modelled: 132 Confidence: 98.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:lipoyltransferase; PDBTitle: structural basis of octanoic acid recognition by lipoate-protein2 ligase b Phyre2 PDB 1j5y chain A Region: 6 - 65 Aligned: 59 Modelled: 60 Confidence: 98.8% Identity: 32% PDB header:transcription Chain: A: PDB Molecule:transcriptional regulator, biotin repressor family; PDBTitle: crystal structure of transcriptional regulator (tm1602) from2 thermotoga maritima at 2.3 a resolution Phyre2 PDB 1j5y chain A domain 1 Region: 4 - 62 Aligned: 58 Modelled: 59 Confidence: 98.8% Identity: 33% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Biotin repressor-like Phyre2 PDB 1w66 chain A domain 1 Region: 116 - 251 Aligned: 128 Modelled: 136 Confidence: 98.6% Identity: 19% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: LplA-like Phyre2 PDB 2y75 chain F Region: 1 - 79 Aligned: 78 Modelled: 79 Confidence: 98.1% Identity: 23% PDB header:transcription Chain: F: PDB Molecule:hth-type transcriptional regulator cymr; PDBTitle: the structure of cymr (yrzc) the global cysteine regulator2 of b. subtilis Phyre2 PDB 1vqz chain A Region: 116 - 250 Aligned: 127 Modelled: 131 Confidence: 98.1% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:lipoate-protein ligase, putative; PDBTitle: crystal structure of a putative lipoate-protein ligase a (sp_1160)2 from streptococcus pneumoniae tigr4 at 1.99 a resolution Phyre2 PDB 1vqz chain A domain 2 Region: 116 - 250 Aligned: 125 Modelled: 135 Confidence: 98.0% Identity: 18% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: LplA-like Phyre2 PDB 2p0l chain A domain 1 Region: 116 - 249 Aligned: 127 Modelled: 134 Confidence: 97.9% Identity: 12% Fold: Class II aaRS and biotin synthetases Superfamily: Class II aaRS and biotin synthetases Family: LplA-like Phyre2 PDB 3edp chain B Region: 6 - 108 Aligned: 102 Modelled: 103 Confidence: 97.9% Identity: 16% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:lin2111 protein; PDBTitle: the crystal structure of the protein lin2111 (functionally unknown)2 from listeria innocua clip11262 Phyre2 1 c2ewnA_ 2 c2ej9A_ 3 c2eayB_ 4 c2cghB_ 5 c3bfmA_ 6 c2dzcA_ 7 d2zgwa2 8 d1biaa3 9 d1biaa1 10 d1biaa2 11 c2qhvA_ 12 c2qhsA_ 13 c1j5yA_ 14 d1j5ya1 15 d1w66a1 16 c2y75F_ 17 c1vqzA_ 18 d1vqza2 19 d2p0la1 20 c3edpB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499