Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	F	M	Q	R	S	K	D	S	L	A	K	W	L	S	A	I	L	P	V	V	I	V	G	L	V	G	L	F	A	V	T	V	I	R	D	Y	G	R	A	S	E	A	D	R	Q	A	L	L	E	K	G	N	V	L	I	R	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	S	G	S	R	V	G	M	G	M	R	M	H	H	V	Q	Q	Q	A	L	L	E	E	M	A	G	Q	P	G	V	L	W	F	A	V	T	D	A	Q	G	I	I	I	L	H	S	D	P	D	K	V	G	R	A	L	Y	S	P	D	E
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	Q	K	L	K	P	E	E	N	S	R	W	R	L	L	G	K	T	E	T	T	P	A	L	E	V	Y	R	L	F	Q	P	M	S	A	P	W	R	H	G	M	H	N	M	P	R	C	N	G	K	A	V	P	Q	V	D	A	Q	Q	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?																				?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	F	I	A	V	D	A	S	D	L	V	A	T	Q	S	G	E	K	R	N	T	L	I	I	L	F	A	L	A	T	V	L	L	A	S	V	L	S	F	F	W	Y	R	R	Y	L	R	S	R	Q	L	L	Q	D	E	M	K	R	K	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	L	V	A	L	G	H	L	A	A	G	V	A	H	E	I	R	N	P	L	S	S	I	K	G	L	A	K	Y	F	A	E	R	A	P	A	G	G	E	A	H	Q	L	A	Q	V	M	A	K	E	A	D	R	L	N	R	V	V	S	E
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	L	E	L	V	K	P	T	H	L	A	L	Q	A	V	D	L	N	T	L	I	N	H	S	L	Q	L	V	S	Q	D	A	N	S	R	E	I	Q	L	R	F	T	A	N	D	T	L	P	E	I	Q	A	D	P	D	R	L	T	Q	V
Secondary structure
SS confidence
Disorder							?	?			?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	L	N	L	Y	L	N	A	I	Q	A	I	G	Q	H	G	V	I	S	V	T	A	S	E	S	G	A	G	V	K	I	S	V	T	D	S	G	K	G	I	A	A	D	Q	L	D	A	I	F	T	P	Y	F	T	T	K	A	E	G	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.
Sequence		G	L	G	L	A	V	V	H	N	I	V	E	Q	H	G	G	T	I	Q	V	A	S	Q	E	G	K	G	S	T	F	T	L	W	L	P	V	N	I	T	R	K	D	P	Q	G
Secondary structure
SS confidence
Disorder															?																							?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3d36 chain B Region: 247 - 458 Aligned: 210 Modelled: 212 Confidence: 100.0% Identity: 32% PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda Phyre2 PDB 2c2a chain A Region: 224 - 458 Aligned: 229 Modelled: 235 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 2q8f chain A Region: 242 - 463 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 3d2r chain B Region: 191 - 463 Aligned: 273 Modelled: 273 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 2bu8 chain A Region: 243 - 463 Aligned: 221 Modelled: 221 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands Phyre2 PDB 1y8o chain A Region: 242 - 463 Aligned: 219 Modelled: 222 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex Phyre2 PDB 1gjv chain A Region: 242 - 462 Aligned: 218 Modelled: 221 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s Phyre2 PDB 3a0r chain A Region: 238 - 461 Aligned: 217 Modelled: 224 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) Phyre2 PDB 3a0t chain A Region: 310 - 461 Aligned: 152 Modelled: 152 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) Phyre2 PDB 1b3q chain A Region: 253 - 462 Aligned: 206 Modelled: 210 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase Phyre2 PDB 2c2a chain A domain 2 Region: 309 - 458 Aligned: 147 Modelled: 150 Confidence: 100.0% Identity: 37% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1id0 chain A Region: 313 - 457 Aligned: 142 Modelled: 145 Confidence: 99.9% Identity: 18% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1gkz chain A domain 2 Region: 312 - 462 Aligned: 150 Modelled: 151 Confidence: 99.9% Identity: 24% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1bxd chain A Region: 308 - 465 Aligned: 152 Modelled: 158 Confidence: 99.9% Identity: 28% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 1jm6 chain A domain 2 Region: 313 - 464 Aligned: 152 Modelled: 151 Confidence: 99.9% Identity: 18% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain Phyre2 PDB 1i58 chain A Region: 313 - 457 Aligned: 145 Modelled: 143 Confidence: 99.9% Identity: 35% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3jz3 chain B Region: 284 - 455 Aligned: 145 Modelled: 149 Confidence: 99.9% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec Phyre2 PDB 2ch4 chain A Region: 313 - 462 Aligned: 150 Modelled: 150 Confidence: 99.9% Identity: 33% PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew Phyre2 PDB 1ysr chain A domain 1 Region: 311 - 458 Aligned: 136 Modelled: 148 Confidence: 99.9% Identity: 26% Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family: Histidine kinase Phyre2 PDB 3gie chain A Region: 221 - 455 Aligned: 197 Modelled: 200 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp Phyre2 PDB 3zrw chain B Region: 195 - 304 Aligned: 104 Modelled: 104 Confidence: 98.6% Identity: 19% PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant Phyre2 PDB 3by8 chain A domain 1 Region: 43 - 128 Aligned: 86 Modelled: 86 Confidence: 93.3% Identity: 26% Fold: Profilin-like Superfamily: Sensory domain-like Family: Sensory domain of two-component sensor kinase Phyre2 PDB 1p0z chain A Region: 47 - 121 Aligned: 75 Modelled: 75 Confidence: 92.4% Identity: 17% Fold: Profilin-like Superfamily: Sensory domain-like Family: Sensory domain of two-component sensor kinase Phyre2 1 c3d36B_ 2 c2c2aA_ 3 c2q8fA_ 4 c3d2rB_ 5 c2bu8A_ 6 c1y8oA_ 7 c1gjvA_ 8 c3a0rA_ 9 c3a0tA_ 10 c1b3qA_ 11 d2c2aa2 12 d1id0a_ 13 d1gkza2 14 d1bxda_ 15 d1jm6a2 16 d1i58a_ 17 c3jz3B_ 18 c2ch4A_ 19 d1ysra1 20 c3gieA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 c3zrwB_ 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 d3by8a1 72 73 d1p0za_ 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3d36B_ 100.0 32 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda 2 c2c2aA_ 100.0 31 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein 3 c2q8fA_ 100.0 17 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 4 c3d2rB_ 100.0 14 PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp 5 c2bu8A_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands 6 c1y8oA_ 100.0 13 PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex 7 c1gjvA_ 100.0 19 PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s 8 c3a0rA_ 100.0 33 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360) 9 c3a0tA_ 100.0 32 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal) 10 c1b3qA_ 100.0 23 PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase 11 d2c2aa2 100.0 37 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 12 d1id0a_ 99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 13 d1gkza2 99.9 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 14 d1bxda_ 99.9 28 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 15 d1jm6a2 99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 16 d1i58a_ 99.9 35 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 17 c3jz3B_ 99.9 27 PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec 18 c2ch4A_ 99.9 33 PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew 19 d1ysra1 99.9 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 20 c3gieA_ 99.9 17 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp 21 d1r62a_ not modelled 99.8 27 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 22 c3ehgA_ not modelled 99.7 18 PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp 23 d2hkja3 not modelled 99.7 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 24 d1ixma_ not modelled 99.7 15 Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B 25 c3zxqA_ not modelled 99.7 21 PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost 26 c3zxoB_ not modelled 99.6 22 PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss 27 c1mx0D_ not modelled 99.6 20 PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit 28 c2zbkB_ not modelled 99.6 21 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms 29 c2q2eB_ not modelled 99.5 21 PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei 30 d1th8a_ not modelled 99.4 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase 31 d1h7sa2 not modelled 99.4 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 32 d1y8oa2 not modelled 99.3 14 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain 33 d1bkna2 not modelled 99.3 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 34 d1b63a2 not modelled 99.2 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 35 d2c2aa1 not modelled 99.0 20 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 36 c3na3A_ not modelled 98.8 23 PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens 37 d1joya_ not modelled 98.8 23 Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase 38 c3zrwB_ 98.6 19 PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant 39 c3h4lB_ not modelled 98.5 24 PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein 40 c1kijB_ not modelled 98.3 21 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin 41 d1kija2 not modelled 98.2 27 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 42 d1pvga2 not modelled 98.1 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 43 d1ei1a2 not modelled 98.1 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 44 c1bknA_ not modelled 98.1 26 PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl 45 c1ei1B_ not modelled 98.0 21 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center 46 d1s16a2 not modelled 98.0 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 47 c1s16B_ not modelled 97.9 20 PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp 48 c1zxnB_ not modelled 97.8 24 PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp 49 c1ea6A_ not modelled 97.8 18 PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp 50 c1y4sA_ not modelled 97.8 27 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding 51 c2iorA_ not modelled 97.7 23 PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp 52 c1qzrA_ not modelled 97.7 21 PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane) 53 c3ke6A_ not modelled 97.7 26 PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis 54 d2gqpa1 not modelled 97.6 28 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 55 c3g7bB_ not modelled 97.6 17 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor 56 d1uyla_ not modelled 97.5 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 57 c3iedA_ not modelled 97.4 23 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn 58 c2fwyA_ not modelled 97.4 16 PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64 59 c2o1wB_ not modelled 97.3 26 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94 60 c2iopD_ not modelled 97.2 26 PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp 61 c2cg9A_ not modelled 97.2 28 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex 62 c3pehB_ not modelled 97.2 24 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative 63 d1uyma_ not modelled 97.1 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 64 d2iwxa1 not modelled 97.1 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 65 c3lnuA_ not modelled 97.1 23 PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit 66 c2akpA_ not modelled 97.1 25 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant 67 c1zwhA_ not modelled 97.0 21 PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine 68 d1s14a_ not modelled 96.9 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain 69 d1qy5a_ not modelled 96.8 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain 70 c2o1uA_ not modelled 96.1 30 PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound 71 d3by8a1 93.3 26 Fold:Profilin-like Superfamily:Sensory domain-like Family:Sensory domain of two-component sensor kinase 72 c3cwvB_ not modelled 92.5 15 PDB header:isomerase Chain: B: PDB Molecule:dna gyrase, b subunit, truncated; PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus 73 d1p0za_ 92.4 17 Fold:Profilin-like Superfamily:Sensory domain-like Family:Sensory domain of two-component sensor kinase 74 d1g0oa_ not modelled 61.7 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 75 c3rd5A_ not modelled 61.0 20 PDB header:oxidoreductase Chain: A: PDB Molecule:mypaa.01249.c; PDBTitle: crystal structure of a putative uncharacterized protein from2 mycobacterium paratuberculosis 76 c3o38D_ not modelled 57.3 25 PDB header:oxidoreductase Chain: D: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of a short chain dehydrogenase from mycobacterium2 smegmatis 77 c3s8mA_ not modelled 53.5 22 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acp reductase; PDBTitle: the crystal structure of fabv 78 d1oaaa_ not modelled 52.5 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 79 d1y5ma1 not modelled 48.4 12 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 80 c2p68A_ not modelled 47.9 19 PDB header:oxidoreductase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] reductase; PDBTitle: crystal structure of aq_1716 from aquifex aeolicus vf5 81 c2z1nA_ not modelled 47.3 27 PDB header:oxidoreductase Chain: A: PDB Molecule:dehydrogenase; PDBTitle: crystal structure of ape0912 from aeropyrum pernix k1 82 c3lmmA_ not modelled 45.2 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35 83 c3f5sA_ not modelled 43.4 15 PDB header:oxidoreductase Chain: A: PDB Molecule:dehydrogenase; PDBTitle: crystal structure of putatitve short chain dehydrogenase from shigella2 flexneri 2a str. 301 84 c3ftpD_ not modelled 42.7 15 PDB header:oxidoreductase Chain: D: PDB Molecule:3-oxoacyl-[acyl-carrier protein] reductase; PDBTitle: crystal structure of 3-ketoacyl-(acyl-carrier-protein)2 reductase from burkholderia pseudomallei at 2.05 a3 resolution 85 c3i1jB_ not modelled 42.3 19 PDB header:oxidoreductase Chain: B: PDB Molecule:oxidoreductase, short chain PDBTitle: structure of a putative short chain dehydrogenase from2 pseudomonas syringae 86 d1qsga_ not modelled 41.7 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 87 d1gz6a_ not modelled 41.7 31 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 88 d2h7ma1 not modelled 41.6 7 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 89 c3ctmH_ not modelled 41.5 17 PDB header:oxidoreductase Chain: H: PDB Molecule:carbonyl reductase; PDBTitle: crystal structure of a carbonyl reductase from candida2 parapsilosis with anti-prelog stereo-specificity 90 c3pxxE_ not modelled 40.9 17 PDB header:oxidoreductase Chain: E: PDB Molecule:carveol dehydrogenase; PDBTitle: crystal structure of carveol dehydrogenase from mycobacterium avium2 bound to nicotinamide adenine dinucleotide 91 d1h5qa_ not modelled 40.8 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 92 c3r1iB_ not modelled 40.5 31 PDB header:oxidoreductase Chain: B: PDB Molecule:short-chain type dehydrogenase/reductase; PDBTitle: crystal structure of a short-chain type dehydrogenase/reductase from2 mycobacterium marinum 93 c3sx2F_ not modelled 40.5 17 PDB header:oxidoreductase Chain: F: PDB Molecule:putative 3-ketoacyl-(acyl-carrier-protein) reductase; PDBTitle: crystal structure of a putative 3-ketoacyl-(acyl-carrier-protein)2 reductase from mycobacterium paratuberculosis in complex with nad 94 d2bela_ not modelled 39.6 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 95 c3uf0A_ not modelled 39.2 23 PDB header:oxidoreductase Chain: A: PDB Molecule:short-chain dehydrogenase/reductase sdr; PDBTitle: crystal structure of a putative nad(p) dependent gluconate 5-2 dehydrogenase from beutenbergia cavernae(efi target efi-502044) with3 bound nadp (low occupancy) 96 c3afnC_ not modelled 39.1 19 PDB header:oxidoreductase Chain: C: PDB Molecule:carbonyl reductase; PDBTitle: crystal structure of aldose reductase a1-r complexed with nadp 97 c2o2sA_ not modelled 38.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-acyl carrier reductase; PDBTitle: the structure of t. gondii enoyl acyl carrier protein reductase in2 complex with nad and triclosan 98 c3gafF_ not modelled 38.2 19 PDB header:oxidoreductase Chain: F: PDB Molecule:7-alpha-hydroxysteroid dehydrogenase; PDBTitle: 2.2a crystal structure of 7-alpha-hydroxysteroid2 dehydrogenase from brucella melitensis 99 c3kvoB_ not modelled 37.6 21 PDB header:oxidoreductase Chain: B: PDB Molecule:hydroxysteroid dehydrogenase-like protein 2; PDBTitle: crystal structure of the catalytic domain of human hydroxysteroid2 dehydrogenase like 2 (hsdl2) 100 c3ak4C_ not modelled 37.1 23 PDB header:oxidoreductase Chain: C: PDB Molecule:nadh-dependent quinuclidinone reductase; PDBTitle: crystal structure of nadh-dependent quinuclidinone reductase from2 agrobacterium tumefaciens 101 c3ek2D_ not modelled 37.1 4 PDB header:oxidoreductase Chain: D: PDB Molecule:enoyl-(acyl-carrier-protein) reductase (nadh); PDBTitle: crystal structure of eonyl-(acyl carrier protein) reductase2 from burkholderia pseudomallei 1719b 102 c3tjrA_ not modelled 37.0 19 PDB header:oxidoreductase Chain: A: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of a rv0851c ortholog short chain dehydrogenase from2 mycobacterium paratuberculosis 103 d1yxma1 not modelled 36.9 31 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 104 c3ai3A_ not modelled 36.0 23 PDB header:oxidoreductase Chain: A: PDB Molecule:nadph-sorbose reductase; PDBTitle: the crystal structure of l-sorbose reductase from gluconobacter2 frateurii complexed with nadph and l-sorbose 105 c3f9iB_ not modelled 35.7 15 PDB header:oxidoreductase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] reductase; PDBTitle: crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase2 rickettsia prowazekii 106 d1xg5a_ not modelled 35.0 27 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 107 d1xsea_ not modelled 35.0 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 108 d1w6ua_ not modelled 34.8 31 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 109 c2ntnB_ not modelled 34.8 21 PDB header:oxidoreductase Chain: B: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] reductase; PDBTitle: crystal structure of maba-c60v/g139a/s144l 110 c2v1bA_ not modelled 34.4 9 PDB header:transferase Chain: A: PDB Molecule:nph1-1; PDBTitle: n- and c-terminal helices of oat lov2 (404-546) are2 involved in light-induced signal transduction (room3 temperature (293k) light structure of lov2 (404-546)) 111 c3emkA_ not modelled 34.4 23 PDB header:oxidoreductase Chain: A: PDB Molecule:glucose/ribitol dehydrogenase; PDBTitle: 2.5a crystal structure of glucose/ribitol dehydrogenase2 from brucella melitensis 112 d1nffa_ not modelled 33.9 19 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 113 c3lf2B_ not modelled 33.9 27 PDB header:oxidoreductase Chain: B: PDB Molecule:short chain oxidoreductase q9hya2; PDBTitle: nadph bound structure of the short chain oxidoreductase q9hya2 from2 pseudomonas aeruginosa pao1 containing an atypical catalytic center 114 c1yb1B_ not modelled 33.3 11 PDB header:oxidoreductase Chain: B: PDB Molecule:17-beta-hydroxysteroid dehydrogenase type xi; PDBTitle: crystal structure of human 17-beta-hydroxysteroid dehydrogenase type2 xi 115 c3ksuA_ not modelled 33.2 7 PDB header:oxidoreductase Chain: A: PDB Molecule:3-oxoacyl-acyl carrier protein reductase; PDBTitle: crystal structure of short-chain dehydrogenase from2 oenococcus oeni psu-1 116 c1zbqB_ not modelled 32.1 31 PDB header:oxidoreductase Chain: B: PDB Molecule:17-beta-hydroxysteroid dehydrogenase 4; PDBTitle: crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 42 in complex with nad 117 d1zbqa1 not modelled 32.1 31 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 118 c3k31B_ not modelled 32.1 13 PDB header:oxidoreductase Chain: B: PDB Molecule:enoyl-(acyl-carrier-protein) reductase; PDBTitle: crystal structure of eonyl-(acyl-carrier-protein) reductase from2 anaplasma phagocytophilum in complex with nad at 1.9a resolution 119 d1j0ga_ not modelled 32.0 30 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like 120 c2vz8B_ not modelled 31.6 21 PDB header:transferase Chain: B: PDB Molecule:fatty acid synthase; PDBTitle: crystal structure of mammalian fatty acid synthase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0