PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: d2iwxa1

Fold library id	Fold	Superfamily	Family
d2iwxa1	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Heat shock protein 90, HSP90, N-terminal domain

Links to external resources
Added to library: Tue Mar 16 12:31:35 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence A S E T F E F Q A E I T Q L M S L I I N T V Y S N K E I F L R E L I S N A S D A L D K I R Y K S L S D P K Q L E T E P D L F I R I T P K P E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T T T T
G G G G T T S
G G

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence Q K V L E I R D S G I G M T K A E L I N N L G T I A K S G T K A F M E A L S A G A D V S M I G Q F G V G F Y S L F L V A D R V Q V I S K S N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G T
S S
T T
S T T
G G G G G G G T
G G G G G G G T
T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence D D E Q Y I W E S N A G G S F T V T L D E V N E R I G R G T I L R L F L K D D Q L E Y L E E K R I K E V I K R H S E F V A Y P I Q L V V T K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T S
S S S
S S S
S S
T T
G G G G
S S

. . .

Sequence E V E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	A	S	E	T	F	E	F	Q	A	E	I	T	Q	L	M	S	L	I	I	N	T	V	Y	S	N	K	E	I	F	L	R	E	L	I	S	N	A	S	D	A	L	D	K	I	R	Y	K	S	L	S	D	P	K	Q	L	E	T	E	P	D	L	F	I	R	I	T	P	K	P	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																								S		T	T																					T	T	T		G	G	G	G	T	T	S											G	G
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	Q	K	V	L	E	I	R	D	S	G	I	G	M	T	K	A	E	L	I	N	N	L	G	T	I	A	K	S	G	T	K	A	F	M	E	A	L	S	A	G	A	D	V	S	M	I	G	Q	F	G	V	G	F	Y	S	L	F	L	V	A	D	R	V	Q	V	I	S	K	S	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	T								S	S												T	T				S	T											T			G	G	G	G	G	G	G	T		G	G	G	G	G	G	G	T											T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	D	D	E	Q	Y	I	W	E	S	N	A	G	G	S	F	T	V	T	L	D	E	V	N	E	R	I	G	R	G	T	I	L	R	L	F	L	K	D	D	Q	L	E	Y	L	E	E	K	R	I	K	E	V	I	K	R	H	S	E	F	V	A	Y	P	I	Q	L	V	V	T	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	S									S	S	S								S	S	S				S	S										T	T		G	G	G	G																	S	S
	.	.	.
Sequence	E	V	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)