Phyre 2 Results for Q62077

Email	l.a.kelley@imperial.ac.uk
Description	Q62077
Date	Tue Jul 30 13:20:18 BST 2013
Unique Job ID	a1fc7b67e52f93b9
Sequence	MAGVATPCAN ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:61.874 Y:91.541 Z:103.599

Model (left) based on template c3ohmB_

Top template information

PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3

Confidence and coverage

Confidence:

100.0%

Coverage:

56%

728 residues ( 56% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A G V A T P C A N G C G P G A P S E A E V L H L C R S L E V G T V M T L F Y S K K S Q R P E R K T F Q V K L E T R Q I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence T W S R G A D K I E G S I D I R E I K E I R P G K T S R D F D R Y Q E D P A F R P D Q S H C F V I L Y G M E F R L K T L

Secondary structure

SS confidence

Disorder
? ? ? ?
?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence S L Q A T S E D E V N M W I K G L T W L M E D T L Q A A T P L Q I E R W L R K Q F Y S V D R N R E D R I S A K D L K N M

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence L S Q V N Y R V P N M R F L R E R L T D L E Q R S G D I T Y G Q F A Q L Y R S L M Y S A Q K T M D L P F L E T N A L R T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?
?
?
?
? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence G E R P E H C Q V S L S E F Q Q F L L E Y Q G E L W A V D R L Q V Q E F M L S F L R D P L R E I E E P Y F F L D E L V T

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence F L F S K E N S V W N S Q L D A V C P D T M N N P L S H Y W I S S S H N T Y L T G D Q F S S E S S L E A Y A R C L R M G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence C R C I E L D C W D G P D G M P V I Y H G H T L T T K I K F S D V L H T I K E H A F V A S E Y P V I L S I E D H C S I A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence Q Q R N M A Q H F R K V L G D T L L T K P V D I A A D G L P S P N Q L R R K I L I K H K K L A E G S A Y E E V P T S V M

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence Y S E N D I S N S I K N G I L Y L E D P V N H E W Y P H Y F V L T S S K I Y Y S E E T S S D Q G N E D E E E P K E A S S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence S T E L H S S E K W F H G K L G A G R D G R H I A E R L L T E Y C I E T G A P D G S F L V R E S E T F V G D Y T L S F W

Secondary structure

SS confidence

Disorder
?
?
?
?
?
? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence R N G K V Q H C R I H S R Q D A G T P K F F L T D N L V F D S L Y D L I T H Y Q Q V P L R C N E F E M R L S E P V P Q T

Secondary structure

SS confidence

Disorder
?
? ? ? ?
?
?
? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence N A H E S K E W Y H A S L T R A Q A E H M L M R V P R D G A F L V R K R N E P N S Y A I S F R A E G K I K H C R V Q Q E

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence G Q T V M L G N S E F D S L V D L I S Y Y E K H P L Y R K M K L R Y P I N E E A L E K I G T A E P D Y G A L Y E G R N P

Secondary structure

SS confidence

Disorder
? ? ? ?
? ?
?
?
? ?
? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence G F Y V E A N P M P T F K C A V K A L F D Y K A Q R E D E L T F T K S A I I Q N V E K Q D G G W W R G D Y G G K K Q L W

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ?
? ?
?
?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence F P S N Y V E E M I N P A V L E P E R E H L D E N S P L G D L L R G V L D V P A C Q I A I R P E G K N N R L F V F S I S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence M P S V A Q W S L D V A A D S Q E E L Q D W V K K I R E V A Q T A D A R L T E G K M M E R R K K I A L E L S E L V V Y C

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ?
?
? ? ? ?
?
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence R P V P F D E E K I G T E R A C Y R D M S S F P E T K A E K Y V N K A K G K K F L Q Y N R L Q L S R I Y P K G Q R L D S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence S N Y D P L P M W I C G S Q L V A L N F Q T P D K P M Q M N Q A L F M A G G H C G Y V L Q P S T M R D E A F D P F D K S

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S L R G L E P C V I C I E V L G A R H L P K N G R G I V C P F V E I E V A G A E Y D S T K Q K T E F V V D N G L N P V W

Secondary structure

SS confidence

Disorder ? ? ?
?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence P A K P F H F Q I S N P E F A F L R F V V Y E E D M F S D Q N F L A Q A T F P V K G L K T G Y R A V P L K N N Y S E D L

Secondary structure

SS confidence

Disorder
?
? ? ?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence E L A S L L I K I D I F P A K E N G D L S P F S G I S L R E R A S D A S S Q L F H V R A R E G S F E A R Y Q Q P F E D F

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . .

Sequence R I S Q E H L A D H F D S R E R S T S D G P S S A T N L I E D P L H D K L W K C S L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 28%)

Alpha helix ( 27%)

Beta strand ( 19%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3ohm chain B

Region: 25 - 1253
Aligned: 728
Modelled: 745
Confidence: 100.0%
Identity: 34%
PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3

Phyre2

PDB 3qr0 chain A

Region: 25 - 1243
Aligned: 744
Modelled: 763
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: A: PDB Molecule:phospholipase c-beta (plc-beta);
PDBTitle: crystal structure of s. officinalis plc21

Phyre2

PDB 2fju chain B

Region: 25 - 1213
Aligned: 673
Modelled: 702
Confidence: 100.0%
Identity: 36%
PDB header:signaling protein,apoptosis/hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: activated rac1 bound to its effector phospholipase c beta 2

Phyre2

PDB 1djy chain B

Region: 170 - 1213
Aligned: 555
Modelled: 569
Confidence: 100.0%
Identity: 44%
PDB header:lipid degradation
Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c,
PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate

Phyre2

PDB 2zkm chain X domain 4

Region: 319 - 1072
Aligned: 292
Modelled: 294
Confidence: 100.0%
Identity: 54%
Fold: TIM beta/alpha-barrel
Superfamily: PLC-like phosphodiesterases
Family: Mammalian PLC

Phyre2

PDB 1qas chain A domain 3

Region: 323 - 1078
Aligned: 276
Modelled: 277
Confidence: 100.0%
Identity: 62%
Fold: TIM beta/alpha-barrel
Superfamily: PLC-like phosphodiesterases
Family: Mammalian PLC

Phyre2

PDB 3gqi chain B

Region: 545 - 770
Aligned: 226
Modelled: 226
Confidence: 100.0%
Identity: 100%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 2b3o chain A

Region: 549 - 762
Aligned: 199
Modelled: 210
Confidence: 100.0%
Identity: 30%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 3ps5 chain A

Region: 549 - 762
Aligned: 199
Modelled: 214
Confidence: 100.0%
Identity: 31%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2shp chain A

Region: 547 - 762
Aligned: 201
Modelled: 216
Confidence: 100.0%
Identity: 32%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2zkm chain X domain 2

Region: 1089 - 1213
Aligned: 118
Modelled: 125
Confidence: 100.0%
Identity: 31%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 2lqn chain A

Region: 538 - 858
Aligned: 302
Modelled: 310
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2oq1 chain A

Region: 549 - 758
Aligned: 195
Modelled: 205
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 1qas chain A domain 2

Region: 1087 - 1213
Aligned: 124
Modelled: 127
Confidence: 99.9%
Identity: 34%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 4fl2 chain A

Region: 549 - 758
Aligned: 195
Modelled: 205
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 2ozo chain A

Region: 549 - 778
Aligned: 215
Modelled: 225
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 1a81 chain E

Region: 547 - 758
Aligned: 200
Modelled: 212
Confidence: 99.9%
Identity: 26%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 2eyz chain A

Region: 538 - 856
Aligned: 288
Modelled: 300
Confidence: 99.9%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2fjl chain A

Region: 489 - 933
Aligned: 150
Modelled: 150
Confidence: 99.9%
Identity: 100%
PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the split ph domain in phospholipase2 c-gamma1

Phyre2

PDB 2zkm chain X domain 3

Region: 25 - 148
Aligned: 122
Modelled: 124
Confidence: 99.9%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

193

194

195

196

197

198

199

200

201

202

203

204

205

206

207

208

209

210

211

212

213

214

215

216

217

218

219

220

221

222

223

224

225

226

227

228

229

230

231

232

233

234

235

236

237

238

239

240

241

242

243

244

245

246

247

248

249

250

251

252

253

254

255

256

257

258

259

260

261

262

263

264

265

266

267

268

269

270

271

272

273

274

275

276

277

278

279

280

281

282

283

284

285

286

287

288

289

290

291

292

293

294

295

296

297

298

299

300

301

302

303

304

305

306

307

308

309

310

311

312

313

314

315

316

317

318

319

320

321

322

323

324

325

326

327

328

329

330

331

332

333

334

335

336

337

338

339

340

341

342

343

344

345

346

347

348

349

350

351

352

353

354

355

356

357

358

359

360

361

362

363

364

365

366

367

368

369

370

371

372

373

374

375

376

377

378

379

380

381

382

383

384

385

386

387

388

389

390

391

392

393

394

395

396

397

398

399

400

401

402

403

404

405

406

407

408

409

410

411

412

413

414

415

416

417

418

419

420

421

422

423

424

425

426

427

428

429

430

431

432

433

434

435

436

437

438

439

440

441

442

443

444

445

446

447

448

449

450

451

452

453

454

455

456

457

458

459

460

461

462

463

464

465

466

467

468

469

470

471

472

473

474

475

476

477

478

479

480

481

482

483

484

485

486

487

488

489

490

491

492

493

494

495

496

497

498

499

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	G	V	A	T	P	C	A	N	G	C	G	P	G	A	P	S	E	A	E	V	L	H	L	C	R	S	L	E	V	G	T	V	M	T	L	F	Y	S	K	K	S	Q	R	P	E	R	K	T	F	Q	V	K	L	E	T	R	Q	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	T	W	S	R	G	A	D	K	I	E	G	S	I	D	I	R	E	I	K	E	I	R	P	G	K	T	S	R	D	F	D	R	Y	Q	E	D	P	A	F	R	P	D	Q	S	H	C	F	V	I	L	Y	G	M	E	F	R	L	K	T	L
Secondary structure
SS confidence
Disorder					?	?	?	?																			?								?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	S	L	Q	A	T	S	E	D	E	V	N	M	W	I	K	G	L	T	W	L	M	E	D	T	L	Q	A	A	T	P	L	Q	I	E	R	W	L	R	K	Q	F	Y	S	V	D	R	N	R	E	D	R	I	S	A	K	D	L	K	N	M
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?													?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	L	S	Q	V	N	Y	R	V	P	N	M	R	F	L	R	E	R	L	T	D	L	E	Q	R	S	G	D	I	T	Y	G	Q	F	A	Q	L	Y	R	S	L	M	Y	S	A	Q	K	T	M	D	L	P	F	L	E	T	N	A	L	R	T
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?		?																	?									?		?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	G	E	R	P	E	H	C	Q	V	S	L	S	E	F	Q	Q	F	L	L	E	Y	Q	G	E	L	W	A	V	D	R	L	Q	V	Q	E	F	M	L	S	F	L	R	D	P	L	R	E	I	E	E	P	Y	F	F	L	D	E	L	V	T
Secondary structure
SS confidence
Disorder		?	?		?																																							?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	F	L	F	S	K	E	N	S	V	W	N	S	Q	L	D	A	V	C	P	D	T	M	N	N	P	L	S	H	Y	W	I	S	S	S	H	N	T	Y	L	T	G	D	Q	F	S	S	E	S	S	L	E	A	Y	A	R	C	L	R	M	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	C	R	C	I	E	L	D	C	W	D	G	P	D	G	M	P	V	I	Y	H	G	H	T	L	T	T	K	I	K	F	S	D	V	L	H	T	I	K	E	H	A	F	V	A	S	E	Y	P	V	I	L	S	I	E	D	H	C	S	I	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	Q	Q	R	N	M	A	Q	H	F	R	K	V	L	G	D	T	L	L	T	K	P	V	D	I	A	A	D	G	L	P	S	P	N	Q	L	R	R	K	I	L	I	K	H	K	K	L	A	E	G	S	A	Y	E	E	V	P	T	S	V	M
Secondary structure
SS confidence
Disorder																									?	?	?																			?	?	?	?	?	?	?	?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	Y	S	E	N	D	I	S	N	S	I	K	N	G	I	L	Y	L	E	D	P	V	N	H	E	W	Y	P	H	Y	F	V	L	T	S	S	K	I	Y	Y	S	E	E	T	S	S	D	Q	G	N	E	D	E	E	E	P	K	E	A	S	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?		?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	S	T	E	L	H	S	S	E	K	W	F	H	G	K	L	G	A	G	R	D	G	R	H	I	A	E	R	L	L	T	E	Y	C	I	E	T	G	A	P	D	G	S	F	L	V	R	E	S	E	T	F	V	G	D	Y	T	L	S	F	W
Secondary structure
SS confidence
Disorder			?		?			?			?		?			?	?	?	?	?	?													?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	R	N	G	K	V	Q	H	C	R	I	H	S	R	Q	D	A	G	T	P	K	F	F	L	T	D	N	L	V	F	D	S	L	Y	D	L	I	T	H	Y	Q	Q	V	P	L	R	C	N	E	F	E	M	R	L	S	E	P	V	P	Q	T
Secondary structure
SS confidence
Disorder																																											?		?	?	?	?		?						?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	N	A	H	E	S	K	E	W	Y	H	A	S	L	T	R	A	Q	A	E	H	M	L	M	R	V	P	R	D	G	A	F	L	V	R	K	R	N	E	P	N	S	Y	A	I	S	F	R	A	E	G	K	I	K	H	C	R	V	Q	Q	E
Secondary structure
SS confidence
Disorder																									?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	G	Q	T	V	M	L	G	N	S	E	F	D	S	L	V	D	L	I	S	Y	Y	E	K	H	P	L	Y	R	K	M	K	L	R	Y	P	I	N	E	E	A	L	E	K	I	G	T	A	E	P	D	Y	G	A	L	Y	E	G	R	N	P
Secondary structure
SS confidence
Disorder																									?	?	?	?																		?	?		?					?		?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	G	F	Y	V	E	A	N	P	M	P	T	F	K	C	A	V	K	A	L	F	D	Y	K	A	Q	R	E	D	E	L	T	F	T	K	S	A	I	I	Q	N	V	E	K	Q	D	G	G	W	W	R	G	D	Y	G	G	K	K	Q	L	W
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?															?	?																										?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	F	P	S	N	Y	V	E	E	M	I	N	P	A	V	L	E	P	E	R	E	H	L	D	E	N	S	P	L	G	D	L	L	R	G	V	L	D	V	P	A	C	Q	I	A	I	R	P	E	G	K	N	N	R	L	F	V	F	S	I	S
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	M	P	S	V	A	Q	W	S	L	D	V	A	A	D	S	Q	E	E	L	Q	D	W	V	K	K	I	R	E	V	A	Q	T	A	D	A	R	L	T	E	G	K	M	M	E	R	R	K	K	I	A	L	E	L	S	E	L	V	V	Y	C
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?			?		?	?	?	?			?		?	?	?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	R	P	V	P	F	D	E	E	K	I	G	T	E	R	A	C	Y	R	D	M	S	S	F	P	E	T	K	A	E	K	Y	V	N	K	A	K	G	K	K	F	L	Q	Y	N	R	L	Q	L	S	R	I	Y	P	K	G	Q	R	L	D	S
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?																																									?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	S	N	Y	D	P	L	P	M	W	I	C	G	S	Q	L	V	A	L	N	F	Q	T	P	D	K	P	M	Q	M	N	Q	A	L	F	M	A	G	G	H	C	G	Y	V	L	Q	P	S	T	M	R	D	E	A	F	D	P	F	D	K	S
Secondary structure
SS confidence
Disorder																																						?	?	?															?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	L	R	G	L	E	P	C	V	I	C	I	E	V	L	G	A	R	H	L	P	K	N	G	R	G	I	V	C	P	F	V	E	I	E	V	A	G	A	E	Y	D	S	T	K	Q	K	T	E	F	V	V	D	N	G	L	N	P	V	W
Secondary structure
SS confidence
Disorder	?	?	?																				?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	P	A	K	P	F	H	F	Q	I	S	N	P	E	F	A	F	L	R	F	V	V	Y	E	E	D	M	F	S	D	Q	N	F	L	A	Q	A	T	F	P	V	K	G	L	K	T	G	Y	R	A	V	P	L	K	N	N	Y	S	E	D	L
Secondary structure
SS confidence
Disorder																								?		?	?	?																													?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	E	L	A	S	L	L	I	K	I	D	I	F	P	A	K	E	N	G	D	L	S	P	F	S	G	I	S	L	R	E	R	A	S	D	A	S	S	Q	L	F	H	V	R	A	R	E	G	S	F	E	A	R	Y	Q	Q	P	F	E	D	F
Secondary structure
SS confidence
Disorder														?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.
Sequence	R	I	S	Q	E	H	L	A	D	H	F	D	S	R	E	R	S	T	S	D	G	P	S	S	A	T	N	L	I	E	D	P	L	H	D	K	L	W	K	C	S	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?	?
Disorder confidence