Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ7M4L6
DateThu Apr 26 09:50:10 BST 2012
Unique Job ID8de3b2dd883ef075

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2eo6A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
Confidence and coverage
Confidence:100.0% Coverage: 25%
104 residues ( 25% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Warning: 74% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGE
Secondary structure 
SS confidence 
Disorder  ????????????????
???????????????
???????????????????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS
Secondary structure 
SS confidence 
Disorder  ????????????????????????
???????????????????????????????????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS
Secondary structure 
SS confidence 
Disorder  ??????????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI
Secondary structure 
SS confidence 
Disorder 
??????
???
Disorder confidence 
 
   ...
Sequence  RTL
Secondary structure 
SS confidence 
Disorder  ???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2eo6 chain A

3D model

Region: 318 - 421
Aligned: 104
Modelled: 104
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2y3a chain B

3D model

Region: 318 - 418
Aligned: 99
Modelled: 101
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 3hiz chain B

3D model

Region: 318 - 421
Aligned: 99
Modelled: 104
Confidence: 100.0%
Identity: 34%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2crh chain A

3D model

Region: 310 - 422
Aligned: 111
Modelled: 113
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 2gsb chain A

3D model

Region: 313 - 422
Aligned: 104
Modelled: 113
Confidence: 99.9%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 317 - 421
Aligned: 100
Modelled: 105
Confidence: 99.9%
Identity: 23%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1pic chain A

3D model

Region: 313 - 421
Aligned: 107
Modelled: 108
Confidence: 99.9%
Identity: 26%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2oq1 chain A

3D model

Region: 317 - 422
Aligned: 101
Modelled: 106
Confidence: 99.9%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 3c7i chain A domain 1

3D model

Region: 318 - 418
Aligned: 99
Modelled: 101
Confidence: 99.9%
Identity: 29%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2eo3 chain A

3D model

Region: 305 - 418
Aligned: 107
Modelled: 112
Confidence: 99.9%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 1ka6 chain A

3D model

Region: 318 - 422
Aligned: 101
Modelled: 105
Confidence: 99.9%
Identity: 23%
PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py

Phyre2

PDB 2shp chain A domain 2

3D model

Region: 319 - 422
Aligned: 102
Modelled: 105
Confidence: 99.9%
Identity: 26%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2dlz chain A

3D model

Region: 316 - 419
Aligned: 102
Modelled: 104
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 2dly chain A

3D model

Region: 309 - 423
Aligned: 110
Modelled: 115
Confidence: 99.9%
Identity: 30%
PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase

Phyre2

PDB 1fhs chain A

3D model

Region: 315 - 419
Aligned: 103
Modelled: 105
Confidence: 99.9%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2vif chain A

3D model

Region: 305 - 420
Aligned: 116
Modelled: 116
Confidence: 99.9%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 2shp chain A

3D model

Region: 319 - 423
Aligned: 103
Modelled: 105
Confidence: 99.9%
Identity: 27%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2fo0 chain A

3D model

Region: 307 - 422
Aligned: 111
Modelled: 116
Confidence: 99.9%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 2eob chain A

3D model

Region: 305 - 421
Aligned: 110
Modelled: 113
Confidence: 99.9%
Identity: 26%
PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2

Phyre2

PDB 1aya chain A

3D model

Region: 320 - 419
Aligned: 98
Modelled: 100
Confidence: 99.9%
Identity: 29%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2cr4 chain A

3D model

Region: 292 - 420
Aligned: 118
Modelled: 118
Confidence: 99.9%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein

Phyre2
1
c2eo6A_
2
c2y3aB_
3
c3hizB_
4
c2crhA_
5
c2gsbA_
6
d2oq1a1
7
d1pica_
8
c2oq1A_
9
d3c7ia1
10
c2eo3A_
11
c1ka6A_
12
d2shpa2
13
c2dlzA_
14
c2dlyA_
15
d1fhsa_
16
c2vifA_
17
c2shpA_
18
c2fo0A_
19
c2eobA_
20
d1ayaa_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
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44
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68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
c2cr4A_
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
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154



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2eo6A_
100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
2c2y3aB_
100.0 27 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
3c3hizB_
100.0 34 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
4c2crhA_
99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
5c2gsbA_
99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
6d2oq1a1
99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
7d1pica_
99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
8c2oq1A_
99.9 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
9d3c7ia1
99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
10c2eo3A_
99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
11c1ka6A_
99.9 23 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
12d2shpa2
99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
13c2dlzA_
99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
14c2dlyA_
99.9 30 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
15d1fhsa_
99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
16c2vifA_
99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
17c2shpA_
99.9 27 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
18c2fo0A_
99.9 31 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
19c2eobA_
99.9 26 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
20d1ayaa_
99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
21c2c9wA_
not modelled 99.9 24 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
22d2izva2
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
23c1x6cA_
not modelled 99.9 30 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
24c2hmhA_
not modelled 99.9 21 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
25c2kk6A_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
26d1opka2
not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
27c2izvA_
not modelled 99.9 19 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
28d1a81e1
not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29c2ysxA_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
30c2dcrA_
not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
31d1blja_
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
32c2ablA_
not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
33c2lctA_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
34d1k9aa2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35d1a81e2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36d1rjaa_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d1mila_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d1qada_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39c2b3oA_
not modelled 99.9 29 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
40d1d4ta_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41d1lkka_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d1a81a1
not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43c2ozoA_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
44d2eyva1
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c2knoA_
not modelled 99.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
46d2oq1a2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d2shpa3
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d1r1qa_
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49d2cs0a1
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d1jwoa_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51d1a81a2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
52c2ci8A_
not modelled 99.9 37 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
53d1g83a2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54d1i3za_
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55c1oplA_
not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
56d1luia_
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57d1fu6a_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58c2ge9A_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
59d1nrva_
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d1csya_
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c2ekxA_
not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
62d2c9wa2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c3gqiB_
not modelled 99.9 21 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
64c3ps5A_
not modelled 99.9 29 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
65d1o48a_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66d2qmsa1
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67d1jyra_
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68c1k9aB_
not modelled 99.9 23 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
69c3nhnA_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
70d1qcfa2
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d1f2fa_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72d1bkla_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
73c1y57A_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
74c1x27F_
not modelled 99.9 26 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
75c2el8A_
not modelled 99.9 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
76d2fcia1
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d1xa6a2
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c1a81E_
not modelled 99.9 18 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
79c3mazA_
not modelled 99.9 11 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
80c2h8hA_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
81d1rpya_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
82c2dm0A_
not modelled 99.9 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
83c2c0iA_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
84c1g83A_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
85c1rqqC_
not modelled 99.9 25 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
86c2eyzA_
not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
87d1cwea_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88c2cr4A_
99.9 19 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
89c2dvjA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
90c3gxxB_
not modelled 99.8 19 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
91c2eyyA_
not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
92c3qwxX_
not modelled 99.8 24 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
93c3qwyA_
not modelled 99.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
94c2dx0B_
not modelled 99.8 33 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
95c3or8A_
not modelled 99.7 19 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
96c1xa6A_
not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
97c2xp1A_
not modelled 99.7 16 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
98d1uura3
not modelled 99.6 11 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
99d1bf5a3
not modelled 99.6 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
100d1bg1a3
not modelled 99.5 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101c3cblA_
not modelled 99.2 37 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
102c1yvlB_
not modelled 98.5 17 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
103c1uusA_
not modelled 98.5 15 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
104c1bf5A_
not modelled 98.2 21 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
105c1y1uA_
not modelled 98.2 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducer and activator of transcription 5a;
PDBTitle: structure of unphosphorylated stat5a
106c1bg1A_
not modelled 98.1 16 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
107c2cblA_
not modelled 98.0 17 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
108c3bunB_
not modelled 98.0 17 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
109c3cwgA_
not modelled 96.8 23 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
110c1griA_
not modelled 95.2 31 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
111c1fbvA_
not modelled 91.4 19 PDB header:ligase
Chain: A: PDB Molecule:signal transduction protein cbl;
PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases
112d2e9ia1
not modelled 69.0 17 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
113d3buxb3
not modelled 68.9 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
114c3op0B_
not modelled 68.1 22 PDB header:signaling protein/signaling protein regu
Chain: B: PDB Molecule:signal transduction protein cbl-c;
PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide
115d1wlha1
not modelled 66.5 13 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
116d2d7na1
not modelled 63.1 20 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
117d2di8a1
not modelled 62.8 13 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
118d2di9a1
not modelled 62.3 7 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
119c1ksrA_
not modelled 61.2 13 PDB header:actin binding protein
Chain: A: PDB Molecule:gelation factor;
PDBTitle: the repeating segments of the f-actin cross-linking2 gelation factor (abp-120) have an immunoglobulin fold, nmr,3 20 structures
120d2d7ma1
not modelled 61.2 13 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)

Binding site prediction 

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