Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ15811
DateTue Apr 3 14:58:12 BST 2012
Unique Job ID2113962007408f17

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2dx1A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
Confidence and coverage
Confidence:100.0% Coverage: 21%
370 residues ( 21% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
774 residues ( 45%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ
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   .........70.........80.........90.........100.........110.........120
Sequence  IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGI
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?
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   .........130.........140.........150.........160.........170.........180
Sequence  ASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLP
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   .........190.........200.........210.........220.........230.........240
Sequence  KSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHL
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???
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   .........250.........260.........270.........280.........290.........300
Sequence  TGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLP
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   .........310.........320.........330.........340.........350.........360
Sequence  PEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFER
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????????????????????????????????????????????????????????
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   .........370.........380.........390.........400.........410.........420
Sequence  GNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE
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   .........430.........440.........450.........460.........470.........480
Sequence  RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEF
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   .........490.........500.........510.........520.........530.........540
Sequence  ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR
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   .........550.........560.........570.........580.........590.........600
Sequence  LIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEI
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   .........610.........620.........630.........640.........650.........660
Sequence  DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQW
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   .........670.........680.........690.........700.........710.........720
Sequence  LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV
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   .........730.........740.........750.........760.........770.........780
Sequence  QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG
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   .........790.........800.........810.........820.........830.........840
Sequence  EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS
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   .........850.........860.........870.........880.........890.........900
Sequence  SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG
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   .........910.........920.........930.........940.........950.........960
Sequence  SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW
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   .........970.........980.........990.........1000.........1010.........1020
Sequence  FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGD
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   .........1030.........1040.........1050.........1060.........1070.........1080
Sequence  LTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQ
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   .........1090.........1100.........1110.........1120.........1130.........1140
Sequence  VIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGT
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   .........1150.........1160.........1170.........1180.........1190.........1200
Sequence  SKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQ
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   .........1210.........1220.........1230.........1240.........1250.........1260
Sequence  VGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVT
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   .........1270.........1280.........1290.........1300.........1310.........1320
Sequence  EIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILS
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   .........1330.........1340.........1350.........1360.........1370.........1380
Sequence  AQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQ
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   .........1390.........1400.........1410.........1420.........1430.........1440
Sequence  RVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHV
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   .........1450.........1460.........1470.........1480.........1490.........1500
Sequence  QCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSG
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   .........1510.........1520.........1530.........1540.........1550.........1560
Sequence  TDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERT
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   .........1570.........1580.........1590.........1600.........1610.........1620
Sequence  AWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPY
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   .........1630.........1640.........1650.........1660.........1670.........1680
Sequence  CEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEI
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   .........1690.........1700.........1710.........1720.
Sequence  RVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2dx1 chain A

3D model

Region: 1155 - 1573
Aligned: 370
Modelled: 392
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 3odo chain A

3D model

Region: 1213 - 1570
Aligned: 355
Modelled: 358
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef

Phyre2

PDB 3ky9 chain B

3D model

Region: 1236 - 1584
Aligned: 315
Modelled: 332
Confidence: 100.0%
Identity: 21%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 1ki1 chain B

3D model

Region: 1229 - 1581
Aligned: 342
Modelled: 353
Confidence: 100.0%
Identity: 95%
PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42

Phyre2

PDB 1xcg chain A

3D model

Region: 1218 - 1572
Aligned: 339
Modelled: 355
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef

Phyre2

PDB 1x86 chain A

3D model

Region: 1216 - 1576
Aligned: 348
Modelled: 361
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa

Phyre2

PDB 3ksy chain A

3D model

Region: 1238 - 1597
Aligned: 344
Modelled: 360
Confidence: 100.0%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)

Phyre2

PDB 3t06 chain E

3D model

Region: 1218 - 1571
Aligned: 341
Modelled: 354
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa

Phyre2

PDB 2dfk chain A

3D model

Region: 1229 - 1591
Aligned: 338
Modelled: 349
Confidence: 100.0%
Identity: 20%
PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex

Phyre2

PDB 1xdv chain B

3D model

Region: 1239 - 1570
Aligned: 312
Modelled: 313
Confidence: 100.0%
Identity: 17%
PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.

Phyre2

PDB 2vrw chain B

3D model

Region: 1234 - 1584
Aligned: 315
Modelled: 324
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor

Phyre2

PDB 1foe chain A

3D model

Region: 1234 - 1577
Aligned: 336
Modelled: 344
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1

Phyre2

PDB 3bji chain A

3D model

Region: 1234 - 1584
Aligned: 317
Modelled: 324
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1

Phyre2

PDB 2z0q chain A

3D model

Region: 1229 - 1571
Aligned: 304
Modelled: 329
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)

Phyre2

PDB 3odx chain A

3D model

Region: 1233 - 1573
Aligned: 326
Modelled: 341
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef

Phyre2

PDB 3odw chain B

3D model

Region: 1233 - 1574
Aligned: 322
Modelled: 328
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef

Phyre2

PDB 1dbh chain A

3D model

Region: 1235 - 1570
Aligned: 328
Modelled: 336
Confidence: 100.0%
Identity: 17%
PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1

Phyre2

PDB 2rgn chain B

3D model

Region: 1226 - 1593
Aligned: 317
Modelled: 330
Confidence: 100.0%
Identity: 16%
PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa

Phyre2

PDB 3mpx chain A

3D model

Region: 1235 - 1569
Aligned: 294
Modelled: 312
Confidence: 100.0%
Identity: 21%
PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5

Phyre2

PDB 1lb1 chain C

3D model

Region: 1233 - 1576
Aligned: 310
Modelled: 330
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa

Phyre2

PDB 3fia chain A

3D model

Region: 6 - 103
Aligned: 98
Modelled: 94
Confidence: 99.8%
Identity: 95%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.

Phyre2

PDB 1gri chain A

3D model

Region: 1006 - 1214
Aligned: 202
Modelled: 202
Confidence: 99.5%
Identity: 24%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 3jzy chain A

3D model

Region: 1595 - 1718
Aligned: 124
Modelled: 124
Confidence: 99.4%
Identity: 73%
PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain

Phyre2

PDB 2eyz chain A

3D model

Region: 975 - 1222
Aligned: 198
Modelled: 198
Confidence: 99.4%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2l3s chain A

3D model

Region: 1077 - 1214
Aligned: 134
Modelled: 134
Confidence: 99.3%
Identity: 25%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2
1

c2dx1A_
2

c3odoA_
3

c3ky9B_
4

c1ki1B_
5

c1xcgA_
6

c1x86A_
7

c3ksyA_
8

c3t06E_
9

c2dfkA_
10

c1xdvB_
11

c2vrwB_
12

c1foeA_
13

c3bjiA_
14

c2z0qA_
15

c3odxA_
16

c3odwB_
17

c1dbhA_
18

c2rgnB_
19

c3mpxA_
20

c1lb1C_
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c3fiaA_
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c1griA_
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c3jzyA_
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c2eyzA_
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c2l3sA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2dx1A_



100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
2c3odoA_



100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef
3c3ky9B_



100.0 21 PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
4c1ki1B_



100.0 95 PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42
5c1xcgA_



100.0 28 PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef
6c1x86A_



100.0 27 PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa
7c3ksyA_



100.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)
8c3t06E_



100.0 28 PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa
9c2dfkA_



100.0 20 PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex
10c1xdvB_



100.0 17 PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.
11c2vrwB_



100.0 21 PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor
12c1foeA_



100.0 21 PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1
13c3bjiA_



100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1
14c2z0qA_



100.0 28 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)
15c3odxA_



100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef
16c3odwB_



100.0 26 PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef
17c1dbhA_



100.0 17 PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1
18c2rgnB_



100.0 16 PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa
19c3mpxA_



100.0 21 PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5
20c1lb1C_



100.0 19 PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa
21c1ntyA_



not modelled 100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:triple functional domain protein;
PDBTitle: crystal structure of the first dh/ph domain of trio to 1.7 a
22d1xcga1



not modelled 100.0 30 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
23d1txda1



not modelled 100.0 28 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
24d1ki1b1



not modelled 99.9 100 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
25d2dfka1



not modelled 99.9 19 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
26d1dbha1



not modelled 99.9 16 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
27c3eo2A_



not modelled 99.9 32 PDB header:splicing
Chain: A: PDB Molecule:neuroepithelial cell-transforming gene 1 protein;
PDBTitle: crystal structure of the rhogef domain of human neuroepithelial cell-2 transforming gene 1 protein
28d1foea1



not modelled 99.9 25 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
29c3gf9A_



not modelled 99.9 79 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 rhogef domain
30d1by1a_



not modelled 99.9 20 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
31d1f5xa_



not modelled 99.9 24 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
32d1kz7a1



not modelled 99.9 23 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
33d1ntya1



not modelled 99.9 22 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
34c3fiaA_



99.8 95 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.
35c2jq6A_



not modelled 99.8 37 PDB header:metal binding protein
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of eh-domain of ehd1
36c2kfhA_



not modelled 99.7 39 PDB header:protein binding
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of the c-terminal domain of ehd1 with fnyestgpftak
37d2jxca1



not modelled 99.7 37 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
38c2qptA_



not modelled 99.6 35 PDB header:endocytosis
Chain: A: PDB Molecule:eh domain-containing protein-2;
PDBTitle: crystal structure of an ehd atpase involved in membrane remodelling
39c2kgrA_



not modelled 99.6 38 PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: solution structure of protein itsn1 from homo sapiens.2 northeast structural genomics consortium target hr5524a
40d1iq3a_



not modelled 99.6 39 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
41d1fi6a_



not modelled 99.6 40 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
42d1c07a_



not modelled 99.5 35 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
43c1griA_



99.5 24 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
44c3jzyA_



99.4 73 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain
45c2lg1A_



not modelled 99.4 19 PDB header:metal binding protein
Chain: A: PDB Molecule:a-kinase anchor protein 13;
PDBTitle: solution structure of the human akap13 ph domain and stabilizing dh2 helix
46d1qjta_



not modelled 99.4 22 Fold:EF Hand-like
Superfamily:EF-hand
Family:Eps15 homology domain (EH domain)
47d1ki1b2



not modelled 99.4 90 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
48c2eyzA_



99.4 22 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
49c2fk9A_



not modelled 99.3 25 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta
50c2l3sA_



99.3 25 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
51c1ng2A_



not modelled 99.2 28 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
52c1mv3A_



not modelled 99.2 14 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
53c1ov3A_



not modelled 99.2 26 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
54c2nq3A_



not modelled 99.2 24 PDB header:ligase
Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase;
PDBTitle: crystal structure of the c2 domain of human itchy homolog2 e3 ubiquitin protein ligase
55d2nq3a1



not modelled 99.2 24 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
56d1gmia_



not modelled 99.0 25 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
57c3nsjA_



not modelled 99.0 21 PDB header:immune system
Chain: A: PDB Molecule:perforin-1;
PDBTitle: the x-ray crystal structure of lymphocyte perforin
58d1udla_



not modelled 99.0 63 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
59d1bdya_



not modelled 98.9 18 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
60c3kwtA_



not modelled 98.9 28 PDB header:metal binding protein
Chain: A: PDB Molecule:munc13-1;
PDBTitle: munc13-1 c2b-domain, calcium-free
61d1wfja_



not modelled 98.9 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
62d2ep6a1



not modelled 98.9 33 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
63c2dmhA_



not modelled 98.9 23 PDB header:lipid binding protein
Chain: A: PDB Molecule:myoferlin;
PDBTitle: solution structure of the first c2 domain of human myoferlin
64d2cjsa1



not modelled 98.9 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
65c3l9bA_



not modelled 98.9 16 PDB header:membrane protein
Chain: A: PDB Molecule:otoferlin;
PDBTitle: crystal structure of rat otoferlin c2a
66d1rlwa_



not modelled 98.8 18 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
67c2jqzA_



not modelled 98.8 29 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf2;
PDBTitle: solution structure of the c2 domain of human smurf2
68c3m7fB_



not modelled 98.8 31 PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex
69d1zc3b1



not modelled 98.8 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
70d1xcga2



not modelled 98.8 22 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
71d2dfka2



not modelled 98.8 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
72c2enjA_



not modelled 98.8 19 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c theta type;
PDBTitle: solution sturcture of the c2 domain from human protein2 kinase c theta
73d1dsya_



not modelled 98.7 29 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
74d1ng2a2



not modelled 98.7 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
75c1dqvA_



not modelled 98.7 22 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin iii;
PDBTitle: crystal structure of synaptotagmin iii c2a/c2b
76d1qasa2



not modelled 98.7 25 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
77d1dbha2



not modelled 98.7 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
78c3nmzD_



not modelled 98.7 24 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
79c3qwmA_



not modelled 98.7 20 PDB header:signaling protein
Chain: A: PDB Molecule:iq motif and sec7 domain-containing protein 1;
PDBTitle: crystal structure of gep100, the plextrin homology domain of iq motif2 and sec7 domain-containing protein 1 isoform a
80d1txda2



not modelled 98.6 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
81c2cubA_



not modelled 98.6 30 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
82c1x2qA_



not modelled 98.6 31 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
83c2r83B_



not modelled 98.6 21 PDB header:endocytosis, exocytosis
Chain: B: PDB Molecule:synaptotagmin-1;
PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b
84c2ysqA_



not modelled 98.6 24 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9;
PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9
85c2eyyA_



not modelled 98.6 21 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
86c2jxbA_



not modelled 98.6 28 PDB header:signaling protein complex
Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain,
PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
87d1ov3a2



not modelled 98.5 26 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
88c2d8kA_



not modelled 98.5 26 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin vii;
PDBTitle: solution structure of the first c2 domain of synaptotagmin2 vii
89c2nsqA_



not modelled 98.5 30 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein;
PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein
90c2ed0A_



not modelled 98.5 35 PDB header:signaling protein
Chain: A: PDB Molecule:abl interactor 2;
PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2)
91c2dnuA_



not modelled 98.5 30 PDB header:structural genomics, structural protein
Chain: A: PDB Molecule:sh3 multiple domains 1;
PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human
92c2dlpA_



not modelled 98.5 31 PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
93c2dbkA_



not modelled 98.5 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structures of the sh3 domain of human crk-like2 protein
94c2yunA_



not modelled 98.5 26 PDB header:protein transport
Chain: A: PDB Molecule:nostrin;
PDBTitle: solution structure of the sh3 domain of human nostrin
95c2rqrA_



not modelled 98.5 8 PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex
96c2ebpA_



not modelled 98.5 26 PDB header:cell adhesion
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1
97c2dl8A_



not modelled 98.5 30 PDB header:signaling protein
Chain: A: PDB Molecule:slit-robo rho gtpase-activating protein 2;
PDBTitle: solution structure of the sh3 domain of human slit-robo rho2 gtpase-activating protein 2
98c2l0aA_



not modelled 98.5 43 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 1;
PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e
99c2yt6A_



not modelled 98.5 26 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
100c2kymA_



not modelled 98.5 30 PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide
101c2oi3A_



not modelled 98.5 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1)
102c2o2oA_



not modelled 98.5 33 PDB header:protein binding
Chain: A: PDB Molecule:sh3-domain kinase-binding protein 1;
PDBTitle: solution structure of domain b from human cin85 protein
103c2ed1A_



not modelled 98.5 37 PDB header:signaling protein
Chain: A: PDB Molecule:130 kda phosphatidylinositol 4,5-biphosphate-
PDBTitle: solution structure of the sh3 domain of 130 kda2 phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase-3 activating protein
104d1k4us_



not modelled 98.5 38 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
105c2yupA_



not modelled 98.5 21 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the second sh3 domain of human vinexin
106c2yuoA_



not modelled 98.5 26 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
107c2csqA_



not modelled 98.5 27 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:rim binding protein 2;
PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2
108d1awwa_



not modelled 98.5 34 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
109d1wiea_



not modelled 98.5 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
110c3qwxX_



not modelled 98.5 26 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
111c2djqA_



not modelled 98.5 27 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:sh3 domain containing ring finger 2;
PDBTitle: the solution structure of the first sh3 domain of mouse sh32 domain containing ring finger 2
112c2ekhA_



not modelled 98.5 25 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structures of the sh3 domain of human kiaa0418
113d2r83a1



not modelled 98.5 23 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
114c3qwyA_



not modelled 98.5 28 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
115c1wi7A_



not modelled 98.5 33 PDB header:protein binding
Chain: A: PDB Molecule:sh3-domain kinase binding protein 1;
PDBTitle: solution structure of the sh3 domain of sh3-domain kinase2 binding protein 1
116d1a25a_



not modelled 98.5 28 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
117c2dl4A_



not modelled 98.5 26 PDB header:signaling protein
Chain: A: PDB Molecule:protein stac;
PDBTitle: solution structure of the first sh3 domain of stac protein
118d1gria2



not modelled 98.4 40 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
119c2dbmA_



not modelled 98.4 31 PDB header:transferase, signaling protein
Chain: A: PDB Molecule:sh3-containing grb2-like protein 2;
PDBTitle: solution structures of the sh3 domain of human sh3-2 containing grb2-like protein 2
120c1x43A_



not modelled 98.4 24 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:sh3 domain grb2-like protein b1;
PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1)

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