Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ06124
DateWed May 9 17:40:46 BST 2012
Unique Job IDcc202f57ce7a7b9f

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3ps5A_
Top template information
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
Confidence and coverage
Confidence:100.0% Coverage: 88%
525 residues ( 88% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
Secondary structure 
SS confidence 
Disorder  ???????
?
??
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
Secondary structure 
SS confidence 
Disorder 
?
?
?
??
????
?
??
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
Secondary structure 
SS confidence 
Disorder  ?
????
???????????????
??
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
Secondary structure 
SS confidence 
Disorder 
???
??????
????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
Secondary structure 
SS confidence 
Disorder  ???
?
???
?
???
?
??????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
Secondary structure 
SS confidence 
Disorder  ?
?????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVW
Secondary structure 
SS confidence 
Disorder 
??
?????????
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK
Secondary structure 
SS confidence 
Disorder 
??
????????
Disorder confidence 
 
   .........550.........560.........570.........580.........590.......
Sequence  RKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Secondary structure 
SS confidence 
Disorder  ?????????????????????????????????????????????
?
?????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3ps5 chain A

3D model

Region: 5 - 537
Aligned: 525
Modelled: 533
Confidence: 100.0%
Identity: 59%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2b3o chain A

3D model

Region: 5 - 534
Aligned: 501
Modelled: 509
Confidence: 100.0%
Identity: 60%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 3 - 529
Aligned: 490
Modelled: 527
Confidence: 100.0%
Identity: 100%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 1lar chain B

3D model

Region: 170 - 529
Aligned: 332
Modelled: 360
Confidence: 100.0%
Identity: 35%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar

Phyre2

PDB 2nlk chain A

3D model

Region: 220 - 526
Aligned: 283
Modelled: 307
Confidence: 100.0%
Identity: 42%
PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)

Phyre2

PDB 1ygu chain A

3D model

Region: 213 - 577
Aligned: 339
Modelled: 358
Confidence: 100.0%
Identity: 31%
PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide

Phyre2

PDB 1wch chain A

3D model

Region: 214 - 535
Aligned: 291
Modelled: 318
Confidence: 100.0%
Identity: 39%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1jln chain A

3D model

Region: 218 - 529
Aligned: 277
Modelled: 309
Confidence: 100.0%
Identity: 40%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2shp chain A domain 1

3D model

Region: 219 - 529
Aligned: 279
Modelled: 311
Confidence: 100.0%
Identity: 100%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1fpr chain A

3D model

Region: 246 - 534
Aligned: 282
Modelled: 289
Confidence: 100.0%
Identity: 60%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2nz6 chain A

3D model

Region: 217 - 533
Aligned: 275
Modelled: 317
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s

Phyre2

PDB 3s3f chain A

3D model

Region: 216 - 528
Aligned: 284
Modelled: 313
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate

Phyre2

PDB 3i36 chain A

3D model

Region: 221 - 527
Aligned: 280
Modelled: 295
Confidence: 100.0%
Identity: 40%
PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain

Phyre2

PDB 2pa5 chain A

3D model

Region: 218 - 528
Aligned: 278
Modelled: 299
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9

Phyre2

PDB 1lar chain A domain 1

3D model

Region: 223 - 537
Aligned: 286
Modelled: 315
Confidence: 100.0%
Identity: 38%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2jjd chain A

3D model

Region: 170 - 527
Aligned: 329
Modelled: 352
Confidence: 100.0%
Identity: 32%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform

Phyre2

PDB 2f71 chain A domain 1

3D model

Region: 225 - 546
Aligned: 294
Modelled: 317
Confidence: 100.0%
Identity: 35%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2vex chain A

3D model

Region: 226 - 546
Aligned: 293
Modelled: 316
Confidence: 100.0%
Identity: 35%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1;
PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor

Phyre2

PDB 2bzl chain A

3D model

Region: 229 - 528
Aligned: 274
Modelled: 300
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution

Phyre2

PDB 2c7s chain A

3D model

Region: 221 - 537
Aligned: 285
Modelled: 311
Confidence: 100.0%
Identity: 42%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution

Phyre2
1
c3ps5A_
2
c2b3oA_
3
c2shpA_
4
c1larB_
5
c2nlkA_
6
c1yguA_
7
d1wcha_
8
d1jlna_
9
d2shpa1
10
d1fpra_
11
c2nz6A_
12
c3s3fA_
13
c3i36A_
14
c2pa5A_
15
d1lara1
16
c2jjdA_
17
d2f71a1
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c2vexA_
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c2bzlA_
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c2c7sA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3ps5A_
100.0 59 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
2c2b3oA_
100.0 60 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
3c2shpA_
100.0 100 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
4c1larB_
100.0 35 PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar
5c2nlkA_
100.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)
6c1yguA_
100.0 31 PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide
7d1wcha_
100.0 39 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
8d1jlna_
100.0 40 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
9d2shpa1
100.0 100 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
10d1fpra_
100.0 60 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
11c2nz6A_
100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s
12c3s3fA_
100.0 37 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate
13c3i36A_
100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain
14c2pa5A_
100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9
15d1lara1
100.0 38 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
16c2jjdA_
100.0 32 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform
17d2f71a1
100.0 35 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
18c2vexA_
100.0 35 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1;
PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor
19c2bzlA_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution
20c2c7sA_
100.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution
21c2hy3A_
not modelled 100.0 43 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma;
PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate
22c2qdmA_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7;
PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant
23d1rpma_
not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
24c2oc3A_
not modelled 100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18
25c2h04A_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,;
PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors
26d1yfoa_
not modelled 100.0 43 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
27c2qcjB_
not modelled 100.0 38 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: native structure of lyp
28c3jrlA_
not modelled 100.0 100 PDB header:hydrolase
Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2;
PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor
29c1l8kA_
not modelled 100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase;
PDBTitle: t cell protein-tyrosine phosphatase structure
30d1l8ka_
not modelled 100.0 37 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
31c2i75A_
not modelled 100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4;
PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
32c2bijA_
not modelled 100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5;
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase)
33d1larb1
not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
34c2b49A_
not modelled 100.0 37 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3;
PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3
35c2g59B_
not modelled 100.0 36 PDB header:hydrolase
Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o;
PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens
36c2qepA_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2;
PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta)
37c1g4wR_
not modelled 100.0 15 PDB header:signaling protein
Chain: R: PDB Molecule:protein tyrosine phosphatase sptp;
PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp
38d1lara2
not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
39c3m4uB_
not modelled 100.0 32 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative;
PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1
40d1p15a_
not modelled 100.0 40 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
41d1lyva_
not modelled 100.0 20 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
42d1g4us2
not modelled 100.0 19 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
43c3gqiB_
not modelled 100.0 33 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
44c2oq1A_
not modelled 100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
45c2ozoA_
not modelled 100.0 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
46c1a81E_
not modelled 100.0 31 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
47c3or8A_
not modelled 100.0 17 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
48c2xp1A_
not modelled 100.0 23 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
49d1v3aa_
not modelled 100.0 24 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
50d1rxda_
not modelled 100.0 28 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
51c3rz2B_
not modelled 99.9 25 PDB header:hydrolase
Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1;
PDBTitle: crystal of prl-1 complexed with peptide
52d2shpa2
not modelled 99.9 99 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53c1x6cA_
not modelled 99.9 50 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
54c3s4oB_
not modelled 99.9 18 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein;
PDBTitle: protein tyrosine phosphatase (putative) from leishmania major
55d2oq1a1
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56c2ci8A_
not modelled 99.9 36 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
57d3c7ia1
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58d2shpa3
not modelled 99.9 100 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59d1ayaa_
not modelled 99.9 100 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60c3hizB_
not modelled 99.9 27 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
61c2eobA_
not modelled 99.9 28 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
62c2y3aB_
not modelled 99.9 26 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
63c2lqnA_
not modelled 99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
64d1a81a1
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65d1nrva_
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66d2oq1a2
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67d1fhsa_
not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68c2ablA_
not modelled 99.9 30 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
69c2fo0A_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
70d1rjaa_
not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d1a81e1
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72c2gsbA_
not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
73c2crhA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
74c2eo6A_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
75d1a81a2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76c2dlzA_
not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
77c2h8hA_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
78c3nhnA_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
79c1k9aB_
not modelled 99.9 28 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
80c2dlyA_
not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
81d1lkka_
not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
82c1y57A_
not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
83c2ysxA_
not modelled 99.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
84d1a81e2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85d1pica_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86c2ge9A_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
87c2lctA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
88c1g83A_
not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
89c2eo3A_
not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
90c1x27F_
not modelled 99.8 31 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
91c1oplA_
not modelled 99.8 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
92c2el8A_
not modelled 99.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
93d1d4ta_
not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1jwoa_
not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c2c0iA_
not modelled 99.8 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
96d1blja_
not modelled 99.8 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97c2kk6A_
not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
98c1ka6A_
not modelled 99.8 26 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
99d1jyra_
not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
100c2vifA_
not modelled 99.8 25 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
101d1qada_
not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
102d2izva2
not modelled 99.8 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
103d1bkla_
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1k9aa2
not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105d2qmsa1
not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106d1qcfa2
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
107d1opka2
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
108d1o48a_
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
109d1r1qa_
not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
110d1f2fa_
not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
111d1csya_
not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
112c2knoA_
not modelled 99.8 24 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
113c2dcrA_
not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
114d1g83a2
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
115d1ohea2
not modelled 99.8 28 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
116d1xa6a2
not modelled 99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
117d1luia_
not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
118d1mila_
not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
119d1i3za_
not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
120c2c9wA_
not modelled 99.8 26 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Binding site prediction 

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