Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP52735
DateWed Jun 6 09:50:28 BST 2012
Unique Job ID3adc006cc7b0d8b4

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3ky9B_
Top template information
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
Confidence and coverage
Confidence:100.0% Coverage: 61%
539 residues ( 61% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
812 residues ( 92%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
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   .........70.........80.........90.........100.........110.........120
Sequence  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
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   .........130.........140.........150.........160.........170.........180
Sequence  AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
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   .........190.........200.........210.........220.........230.........240
Sequence  QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
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   .........250.........260.........270.........280.........290.........300
Sequence  FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
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   .........310.........320.........330.........340.........350.........360
Sequence  LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
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   .........370.........380.........390.........400.........410.........420
Sequence  EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
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   .........430.........440.........450.........460.........470.........480
Sequence  TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY
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   .........490.........500.........510.........520.........530.........540
Sequence  LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
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   .........550.........560.........570.........580.........590.........600
Sequence  KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
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   .........610.........620.........630.........640.........650.........660
Sequence  PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
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   .........670.........680.........690.........700.........710.........720
Sequence  PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
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   .........730.........740.........750.........760.........770.........780
Sequence  KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
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   .........790.........800.........810.........820.........830.........840
Sequence  SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG
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   .........850.........860.........870........
Sequence  DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3ky9 chain B

3D model

Region: 2 - 573
Aligned: 539
Modelled: 567
Confidence: 100.0%
Identity: 56%
PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1

Phyre2

PDB 2vrw chain B

3D model

Region: 194 - 572
Aligned: 366
Modelled: 379
Confidence: 100.0%
Identity: 54%
PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor

Phyre2

PDB 3bji chain A

3D model

Region: 193 - 573
Aligned: 371
Modelled: 381
Confidence: 100.0%
Identity: 54%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1

Phyre2

PDB 3ksy chain A

3D model

Region: 198 - 515
Aligned: 313
Modelled: 318
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)

Phyre2

PDB 2dx1 chain A

3D model

Region: 164 - 515
Aligned: 329
Modelled: 330
Confidence: 100.0%
Identity: 27%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 3odo chain A

3D model

Region: 179 - 513
Aligned: 334
Modelled: 335
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef

Phyre2

PDB 1xdv chain B

3D model

Region: 199 - 533
Aligned: 319
Modelled: 335
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.

Phyre2

PDB 1x86 chain A

3D model

Region: 180 - 518
Aligned: 334
Modelled: 339
Confidence: 100.0%
Identity: 18%
PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa

Phyre2

PDB 1xcg chain A

3D model

Region: 180 - 514
Aligned: 329
Modelled: 335
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef

Phyre2

PDB 2dfk chain A

3D model

Region: 188 - 514
Aligned: 326
Modelled: 327
Confidence: 100.0%
Identity: 24%
PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex

Phyre2

PDB 3t06 chain E

3D model

Region: 180 - 514
Aligned: 332
Modelled: 335
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa

Phyre2

PDB 3odx chain A

3D model

Region: 194 - 517
Aligned: 315
Modelled: 324
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef

Phyre2

PDB 3odw chain B

3D model

Region: 194 - 517
Aligned: 311
Modelled: 311
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef

Phyre2

PDB 2rgn chain B

3D model

Region: 193 - 513
Aligned: 292
Modelled: 321
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa

Phyre2

PDB 1foe chain A

3D model

Region: 193 - 513
Aligned: 319
Modelled: 321
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1

Phyre2

PDB 3mpx chain A

3D model

Region: 197 - 510
Aligned: 289
Modelled: 296
Confidence: 100.0%
Identity: 16%
PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5

Phyre2

PDB 2z0q chain A

3D model

Region: 193 - 512
Aligned: 301
Modelled: 305
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)

Phyre2

PDB 1ki1 chain B

3D model

Region: 193 - 522
Aligned: 321
Modelled: 330
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42

Phyre2

PDB 1dbh chain A

3D model

Region: 198 - 512
Aligned: 311
Modelled: 315
Confidence: 100.0%
Identity: 20%
PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1

Phyre2

PDB 1lb1 chain C

3D model

Region: 196 - 513
Aligned: 299
Modelled: 318
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa

Phyre2

PDB 2lqn chain A

3D model

Region: 661 - 874
Aligned: 212
Modelled: 212
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2eyz chain A

3D model

Region: 662 - 874
Aligned: 211
Modelled: 211
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 1gri chain A

3D model

Region: 590 - 874
Aligned: 205
Modelled: 205
Confidence: 100.0%
Identity: 28%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2eyy chain A

3D model

Region: 662 - 874
Aligned: 187
Modelled: 187
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i

Phyre2

PDB 2dvj chain A

3D model

Region: 662 - 874
Aligned: 170
Modelled: 170
Confidence: 99.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii

Phyre2

PDB 3qwx chain X

3D model

Region: 667 - 875
Aligned: 154
Modelled: 154
Confidence: 99.9%
Identity: 21%
PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174

Phyre2
1

c3ky9B_
2

c2vrwB_
3

c3bjiA_
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c3ksyA_
5

c2dx1A_
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c3odoA_
7

c1xdvB_
8

c1x86A_
9

c1xcgA_
10

c2dfkA_
11

c3t06E_
12

c3odxA_
13

c3odwB_
14

c2rgnB_
15

c1foeA_
16

c3mpxA_
17

c2z0qA_
18

c1ki1B_
19

c1dbhA_
20

c1lb1C_
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c2lqnA_
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c2eyzA_
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c1griA_
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c2eyyA_
39

c2dvjA_
40

c3qwxX_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3ky9B_



100.0 56 PDB header:apoptosis
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: autoinhibited vav1
2c2vrwB_



100.0 54 PDB header:signaling protein
Chain: B: PDB Molecule:proto-oncogene vav;
PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor
3c3bjiA_



100.0 54 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1
4c3ksyA_



100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:son of sevenless homolog 1;
PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos)
5c2dx1A_



100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
6c3odoA_



100.0 19 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the dh/ph domains of p115-rhogef
7c1xdvB_



100.0 21 PDB header:signaling protein
Chain: B: PDB Molecule:son of sevenless protein homolog 1;
PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang.
8c1x86A_



100.0 18 PDB header:signaling protein/membrane protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12;
PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa
9c1xcgA_



100.0 21 PDB header:signaling protein activator/signaling pr
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef
10c2dfkA_



100.0 24 PDB header:cell cycle
Chain: A: PDB Molecule:collybistin ii;
PDBTitle: crystal structure of the cdc42-collybistin ii complex
11c3t06E_



100.0 20 PDB header:signaling protein
Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11;
PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa
12c3odxA_



100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef
13c3odwB_



100.0 22 PDB header:signaling protein
Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1;
PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef
14c2rgnB_



100.0 21 PDB header:signaling protein complex
Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor;
PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa
15c1foeA_



100.0 19 PDB header:signaling protein, immune system/signali
Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing
PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1
16c3mpxA_



100.0 16 PDB header:lipid binding protein
Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5;
PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5
17c2z0qA_



100.0 22 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3;
PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln)
18c1ki1B_



100.0 20 PDB header:signaling protein
Chain: B: PDB Molecule:intersectin long form;
PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42
19c1dbhA_



100.0 20 PDB header:gene regulation
Chain: A: PDB Molecule:protein (human sos 1);
PDBTitle: dbl and pleckstrin homology domains from hsos1
20c1lb1C_



100.0 22 PDB header:signaling protein
Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs;
PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa
21c1ntyA_



not modelled 100.0 17 PDB header:signaling protein
Chain: A: PDB Molecule:triple functional domain protein;
PDBTitle: crystal structure of the first dh/ph domain of trio to 1.7 a
22d1xcga1



not modelled 100.0 22 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
23d1txda1



not modelled 100.0 19 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
24d1dbha1



not modelled 100.0 20 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
25d1f5xa_



not modelled 100.0 49 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
26d1ki1b1



not modelled 100.0 25 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
27d2dfka1



not modelled 100.0 27 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
28c2d86A_



not modelled 100.0 71 PDB header:signaling protein, protein binding
Chain: A: PDB Molecule:vav-3 protein;
PDBTitle: solution structure of the ch domain from human vav-3 protein
29c3eo2A_



not modelled 100.0 27 PDB header:splicing
Chain: A: PDB Molecule:neuroepithelial cell-transforming gene 1 protein;
PDBTitle: crystal structure of the rhogef domain of human neuroepithelial cell-2 transforming gene 1 protein
30d1kz7a1



not modelled 100.0 26 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
31d1foea1



not modelled 100.0 28 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
32d1ntya1



not modelled 100.0 21 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
33c3gf9A_



not modelled 100.0 24 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 rhogef domain
34d1by1a_



not modelled 100.0 27 Fold:DBL homology domain (DH-domain)
Superfamily:DBL homology domain (DH-domain)
Family:DBL homology domain (DH-domain)
35c2lqnA_



100.0 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
36c2eyzA_



100.0 25 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
37c1griA_



100.0 28 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
38c2eyyA_



100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
39c2dvjA_



99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
40c3qwxX_



99.9 21 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
41c3qwyA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
42c2l3gA_



not modelled 99.9 37 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7;
PDBTitle: solution nmr structure of ch domain of rho guanine nucleotide exchange2 factor 7 from homo sapiens, northeast structural genomics consortium3 target hr4495e
43d1ujoa_



not modelled 99.9 23 Fold:CH domain-like
Superfamily:Calponin-homology domain, CH-domain
Family:Calponin-homology domain, CH-domain
44c1wymA_



not modelled 99.9 18 PDB header:structural protein
Chain: A: PDB Molecule:transgelin-2;
PDBTitle: solution structure of the ch domain of human transgelin-2
45c1wyrA_



not modelled 99.9 32 PDB header:structural protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 6;
PDBTitle: solution structure of the ch domain of human rho guanine2 nucleotide exchange factor 6
46c1mv3A_



not modelled 99.9 18 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
47c2l3sA_



not modelled 99.9 26 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
48c1wypA_



not modelled 99.8 23 PDB header:structural protein
Chain: A: PDB Molecule:calponin 1;
PDBTitle: solution structure of the ch domain of human calponin 1
49c2lg1A_



not modelled 99.8 10 PDB header:metal binding protein
Chain: A: PDB Molecule:a-kinase anchor protein 13;
PDBTitle: solution structure of the human akap13 ph domain and stabilizing dh2 helix
50c1wynA_



not modelled 99.8 23 PDB header:structural protein
Chain: A: PDB Molecule:calponin-2;
PDBTitle: solution structure of the ch domain of human calponin-2
51c1ov3A_



not modelled 99.8 28 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
52c1ng2A_



not modelled 99.8 31 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
53d1p2xa_



not modelled 99.8 21 Fold:CH domain-like
Superfamily:Calponin-homology domain, CH-domain
Family:Calponin-homology domain, CH-domain
54c1p5sA_



not modelled 99.8 21 PDB header:cytokine
Chain: A: PDB Molecule:ras gtpase-activating-like protein rng2;
PDBTitle: structure and function of the calponin-homology domain of2 an iqgap protein from schizosaccharomyces pombe
55d1h67a_



not modelled 99.8 26 Fold:CH domain-like
Superfamily:Calponin-homology domain, CH-domain
Family:Calponin-homology domain, CH-domain
56c2rqrA_



not modelled 99.8 22 PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex
57c3i6xC_



not modelled 99.8 23 PDB header:calmodulin-binding, membrane protein
Chain: C: PDB Molecule:ras gtpase-activating-like protein iqgap1;
PDBTitle: crystal structure of the calponin homology domain of iqgap1
58c2jxbA_



not modelled 99.8 16 PDB header:signaling protein complex
Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain,
PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
59d1ng2a2



not modelled 99.8 26 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
60c3nmzD_



not modelled 99.7 23 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
61c1x43A_



not modelled 99.7 28 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:sh3 domain grb2-like protein b1;
PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1)
62c2dlpA_



not modelled 99.7 23 PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
63c1zlmA_



not modelled 99.7 40 PDB header:signaling protein
Chain: A: PDB Molecule:osteoclast stimulating factor 1;
PDBTitle: crystal structure of the sh3 domain of human osteoclast2 stimulating factor
64c1x2qA_



not modelled 99.7 30 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
65c2ed0A_



not modelled 99.7 30 PDB header:signaling protein
Chain: A: PDB Molecule:abl interactor 2;
PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2)
66d1ov3a2



not modelled 99.7 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
67d1uj0a_



not modelled 99.7 31 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
68c1k9aB_



not modelled 99.7 23 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
69c2csqA_



not modelled 99.7 26 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:rim binding protein 2;
PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2
70c2l0aA_



not modelled 99.7 31 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 1;
PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e
71c2e5kA_



not modelled 99.7 21 PDB header:protein binding
Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1;
PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1
72c2cubA_



not modelled 99.7 34 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
73d1k4us_



not modelled 99.7 27 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
74d2dfka2



not modelled 99.7 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
75c2oi3A_



not modelled 99.7 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1)
76c2xmfA_



not modelled 99.7 34 PDB header:motor protein
Chain: A: PDB Molecule:myosin 1e sh3;
PDBTitle: myosin 1e sh3
77d1i1ja_



not modelled 99.7 33 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
78c2nwmA_



not modelled 99.7 41 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin
79d1oota_



not modelled 99.7 44 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
80c2ysqA_



not modelled 99.7 30 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9;
PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9
81c2yt6A_



not modelled 99.7 24 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
82c1wx6A_



not modelled 99.7 24 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:cytoplasmic protein nck2;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck2
83d1u5sa1



not modelled 99.7 26 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
84c2df6A_



not modelled 99.7 42 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7;
PDBTitle: crystal structure of the sh3 domain of betapix in complex2 with a high affinity peptide from pak2
85d1gcqa_



not modelled 99.7 34 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
86c1x6gA_



not modelled 99.7 19 PDB header:signaling protein
Chain: A: PDB Molecule:megakaryocyte-associated tyrosine-protein kinase;
PDBTitle: solution structures of the sh3 domain of human2 megakaryocyte-associated tyrosine-protein kinase.
87c2kbtA_



not modelled 99.7 61 PDB header:signaling protein
Chain: A: PDB Molecule:chimera of proto-oncogene vav, linker,
PDBTitle: attachment of an nmr-invisible solubility enhancement tag2 (inset) using a sortase-mediated protein ligation method
88d1sema_



not modelled 99.7 35 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
89c2d8hA_



not modelled 99.7 25 PDB header:unknown function
Chain: A: PDB Molecule:sh3yl1 protein;
PDBTitle: solution structure of the sh3 domain of hypothetical2 protein sh3yl1
90c2cudA_



not modelled 99.7 20 PDB header:signaling protein
Chain: A: PDB Molecule:src-like-adapter;
PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap)
91d1utia_



not modelled 99.7 35 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
92d1wlpb2



not modelled 99.7 25 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
93c2yupA_



not modelled 99.7 31 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the second sh3 domain of human vinexin
94c1x6bA_



not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine exchange factor (gef) 16;
PDBTitle: solution structures of the sh3 domain of human rho guanine2 exchange factor (gef) 16
95c2k6dA_



not modelled 99.7 34 PDB header:sh3 domain/ubiquitin
Chain: A: PDB Molecule:sh3 domain-containing kinase-binding protein 1;
PDBTitle: cin85 sh3-c domain in complex with ubiquitin
96c2yunA_



not modelled 99.7 42 PDB header:protein transport
Chain: A: PDB Molecule:nostrin;
PDBTitle: solution structure of the sh3 domain of human nostrin
97c2dbkA_



not modelled 99.7 37 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structures of the sh3 domain of human crk-like2 protein
98c2dmoA_



not modelled 99.7 23 PDB header:signaling protein
Chain: A: PDB Molecule:neutrophil cytosol factor 2;
PDBTitle: refined solution structure of the 1st sh3 domain from human2 neutrophil cytosol factor 2 (ncf-2)
99d1udla_



not modelled 99.7 26 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
100c2js0A_



not modelled 99.7 42 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of second sh3 domain of adaptor nck
101d1uuea_



not modelled 99.7 31 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
102d1wiea_



not modelled 99.7 28 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
103c2yuoA_



not modelled 99.7 37 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
104d1oeba_



not modelled 99.7 33 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
105d1uhca_



not modelled 99.7 29 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
106c2epdA_



not modelled 99.7 38 PDB header:protein binding
Chain: A: PDB Molecule:rho gtpase-activating protein 4;
PDBTitle: solution structure of sh3 domain in rho-gtpase-activating2 protein 4
107c1wyxA_



not modelled 99.7 33 PDB header:cell adhesion
Chain: A: PDB Molecule:crk-associated substrate;
PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution
108d1u06a1



not modelled 99.7 30 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
109d1ov3a1



not modelled 99.7 24 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
110c2dl4A_



not modelled 99.7 32 PDB header:signaling protein
Chain: A: PDB Molecule:protein stac;
PDBTitle: solution structure of the first sh3 domain of stac protein
111d1ycsb2



not modelled 99.7 27 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
112c1zx6A_



not modelled 99.7 35 PDB header:protein binding
Chain: A: PDB Molecule:ypr154wp;
PDBTitle: high-resolution crystal structure of yeast pin3 sh3 domain
113d1gria2



not modelled 99.7 34 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
114c2d1xD_



not modelled 99.7 40 PDB header:cell invasion
Chain: D: PDB Molecule:cortactin isoform a;
PDBTitle: the crystal structure of the cortactin-sh3 domain and amap1-2 peptide complex
115c2fpeB_



not modelled 99.7 26 PDB header:signaling protein
Chain: B: PDB Molecule:c-jun-amino-terminal kinase interacting protein
PDBTitle: conserved dimerization of the ib1 src-homology 3 domain
116c2dm1A_



not modelled 99.7 91 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the second sh3 domain of human2 protein vav-2
117c3rnjA_



not modelled 99.7 30 PDB header:protein binding
Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein
PDBTitle: crystal structure of the sh3 domain from irsp53 (baiap2)
118c2ekhA_



not modelled 99.7 20 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structures of the sh3 domain of human kiaa0418
119c2ebpA_



not modelled 99.7 31 PDB header:cell adhesion
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1
120c2dnuA_



not modelled 99.7 19 PDB header:structural genomics, structural protein
Chain: A: PDB Molecule:sh3 multiple domains 1;
PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human

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