Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionO00459
DateFri May 25 09:44:30 BST 2012
Unique Job ID0ae9a79684a9af6d

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2oq1A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
Confidence and coverage
Confidence:100.0% Coverage: 34%
247 residues ( 34% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
659 residues ( 91%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
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Disorder  ???????








?

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?????????????????????




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   .........70.........80.........90.........100.........110.........120
Sequence  NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
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Disorder 

?????
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?????????????????????????





?
????
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   .........130.........140.........150.........160.........170.........180
Sequence  PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
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???
























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   .........190.........200.........210.........220.........230.........240
Sequence  LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALG
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   .........250.........260.........270.........280.........290.........300
Sequence  PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
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Disorder  ???

?????

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   .........310.........320.........330.........340.........350.........360
Sequence  ALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
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Disorder  ??????
??

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   .........370.........380.........390.........400.........410.........420
Sequence  IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
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?????






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   .........430.........440.........450.........460.........470.........480
Sequence  LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
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Disorder 







?????



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???????













???????
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   .........490.........500.........510.........520.........530.........540
Sequence  IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
Secondary structure 


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?????

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   .........550.........560.........570.........580.........590.........600
Sequence  KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
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Disorder 










???????

??????????

??????
????????


????
?????
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   .........610.........620.........630.........640.........650.........660
Sequence  TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
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Disorder  ?????
?????????????
















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   .........670.........680.........690.........700.........710.........720
Sequence  VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
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??














?
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   ........
Sequence  PGPPPAAR
Secondary structure 







SS confidence 







Disorder  ????????
Disorder confidence 







 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2oq1 chain A

3D model

Region: 324 - 724
Aligned: 247
Modelled: 265
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2ozo chain A

3D model

Region: 322 - 716
Aligned: 248
Modelled: 259
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 2y3a chain B

3D model

Region: 447 - 720
Aligned: 236
Modelled: 242
Confidence: 100.0%
Identity: 100%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 2b3o chain A

3D model

Region: 330 - 716
Aligned: 197
Modelled: 200
Confidence: 100.0%
Identity: 35%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 326 - 716
Aligned: 201
Modelled: 204
Confidence: 100.0%
Identity: 30%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 1a81 chain E

3D model

Region: 324 - 716
Aligned: 212
Modelled: 223
Confidence: 100.0%
Identity: 32%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 3ps5 chain A

3D model

Region: 330 - 719
Aligned: 200
Modelled: 203
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 1xa6 chain A

3D model

Region: 88 - 291
Aligned: 198
Modelled: 204
Confidence: 100.0%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin

Phyre2

PDB 3gqi chain B

3D model

Region: 327 - 716
Aligned: 194
Modelled: 202
Confidence: 100.0%
Identity: 30%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 3hiz chain B

3D model

Region: 324 - 576
Aligned: 234
Modelled: 238
Confidence: 100.0%
Identity: 77%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2ee5 chain A

3D model

Region: 86 - 298
Aligned: 205
Modelled: 213
Confidence: 100.0%
Identity: 20%
PDB header:hydrolase
Chain: A: PDB Molecule:rho gtpase activating protein 5 variant;
PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant

Phyre2

PDB 2xs6 chain A

3D model

Region: 109 - 260
Aligned: 150
Modelled: 149
Confidence: 100.0%
Identity: 93%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of the rhogap domain of human pik3r2

Phyre2

PDB 3byi chain A

3D model

Region: 99 - 292
Aligned: 187
Modelled: 189
Confidence: 100.0%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 15;
PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15)

Phyre2

PDB 2ngr chain B

3D model

Region: 102 - 291
Aligned: 184
Modelled: 190
Confidence: 100.0%
Identity: 21%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (gtpase activating protein (rhg));
PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap.

Phyre2

PDB 3qis chain A

3D model

Region: 105 - 260
Aligned: 153
Modelled: 156
Confidence: 100.0%
Identity: 20%
PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl

Phyre2

PDB 1xa6 chain A domain 1

3D model

Region: 105 - 291
Aligned: 181
Modelled: 187
Confidence: 100.0%
Identity: 21%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 1tx4 chain A

3D model

Region: 103 - 291
Aligned: 183
Modelled: 189
Confidence: 100.0%
Identity: 21%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 3msx chain B

3D model

Region: 104 - 291
Aligned: 181
Modelled: 184
Confidence: 100.0%
Identity: 15%
PDB header:protein binding
Chain: B: PDB Molecule:rho gtpase-activating protein 20;
PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20

Phyre2

PDB 3kuq chain A

3D model

Region: 103 - 288
Aligned: 176
Modelled: 186
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 7;
PDBTitle: crystal structure of the dlc1 rhogap domain

Phyre2

PDB 3iug chain A

3D model

Region: 103 - 291
Aligned: 168
Modelled: 171
Confidence: 100.0%
Identity: 22%
PDB header:splicing
Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics;
PDBTitle: crystal structure of the rhogap domain of rics

Phyre2

PDB 2kt1 chain A

3D model

Region: 1 - 80
Aligned: 80
Modelled: 80
Confidence: 99.4%
Identity: 100%
PDB header:protein binding
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: solution nmr structure of the sh3 domain from the p85beta2 subunit of phosphatidylinositol 3-kinase from h.sapiens,3 northeast structural genomics consortium target hr5531e

Phyre2
1

c2oq1A_
2

c2ozoA_
3

c2y3aB_
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c2b3oA_
5

c2shpA_
6

c1a81E_
7

c3ps5A_
8

c1xa6A_
9

c3gqiB_
10

c3hizB_
11

c2ee5A_
12

c2xs6A_
13

c3byiA_
14

c2ngrB_
15

c3qisA_
16

d1xa6a1
17

d1tx4a_
18

c3msxB_
19

c3kuqA_
20

c3iugA_
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c2kt1A_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2oq1A_



100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
2c2ozoA_



100.0 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
3c2y3aB_



100.0 100 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
4c2b3oA_



100.0 35 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
5c2shpA_



100.0 30 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
6c1a81E_



100.0 32 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
7c3ps5A_



100.0 29 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
8c1xa6A_



100.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
9c3gqiB_



100.0 30 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
10c3hizB_



100.0 77 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
11c2ee5A_



100.0 20 PDB header:hydrolase
Chain: A: PDB Molecule:rho gtpase activating protein 5 variant;
PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant
12c2xs6A_



100.0 93 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of the rhogap domain of human pik3r2
13c3byiA_



100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 15;
PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15)
14c2ngrB_



100.0 21 PDB header:hydrolase
Chain: B: PDB Molecule:protein (gtpase activating protein (rhg));
PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap.
15c3qisA_



100.0 20 PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl
16d1xa6a1



100.0 21 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
17d1tx4a_



100.0 21 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
18c3msxB_



100.0 15 PDB header:protein binding
Chain: B: PDB Molecule:rho gtpase-activating protein 20;
PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20
19c3kuqA_



100.0 15 PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 7;
PDBTitle: crystal structure of the dlc1 rhogap domain
20c3iugA_



100.0 22 PDB header:splicing
Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics;
PDBTitle: crystal structure of the rhogap domain of rics
21d1pbwa_



not modelled 100.0 35 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
22c3fk2B_



not modelled 100.0 19 PDB header:signaling protein, hydrolase activator
Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1;
PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1
23c1pbwB_



not modelled 100.0 35 PDB header:phosphotransferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase;
PDBTitle: structure of bcr-homology (bh) domain
24d1f7ca_



not modelled 100.0 23 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
25c1f7cA_



not modelled 100.0 23 PDB header:signaling protein
Chain: A: PDB Molecule:rhogap protein;
PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase
26c2ovjA_



not modelled 100.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:rac gtpase-activating protein 1;
PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap.
27c2qv2A_



not modelled 100.0 22 PDB header:hydrolase
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway
28c3eapD_



not modelled 99.9 20 PDB header:hydrolase activator
Chain: D: PDB Molecule:rho gtpase-activating protein 11a;
PDBTitle: crystal structure of the rhogap domain of arhgap11a
29d2oq1a1



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1pica_



not modelled 99.9 73 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31d1qada_



not modelled 99.9 79 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
32d1a81a1



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
33c2dlyA_



not modelled 99.9 35 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
34d2oq1a2



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35c2crhA_



not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
36d1a81e1



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d1a81a2



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38c2dlzA_



not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
39d1a81e2



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40c2eo6A_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
41c2fo0A_



not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
42c2ablA_



not modelled 99.9 34 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
43c2lctA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
44c2ge9A_



not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
45c2eobA_



not modelled 99.9 31 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
46c1oplA_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
47d1csya_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48c2gsbA_



not modelled 99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
49d1opka2



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d1lkka_



not modelled 99.9 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51d1qcfa2



not modelled 99.9 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
52d2shpa2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53d1jwoa_



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54d1nrva_



not modelled 99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d1k9aa2



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56c2ysxA_



not modelled 99.8 29 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
57c1y57A_



not modelled 99.8 31 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
58c2knoA_



not modelled 99.8 32 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
59d1o48a_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d1rjaa_



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c2lqnA_



not modelled 99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
62c1k9aB_



not modelled 99.8 29 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
63d1bkla_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64c1ka6A_



not modelled 99.8 29 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
65d1luia_



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66d1blja_



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67d2qmsa1



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68c3nhnA_



not modelled 99.8 36 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
69d1fhsa_



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
70d1g83a2



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71c2eo3A_



not modelled 99.8 30 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
72d1f2fa_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
73d1ayaa_



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c1x27F_



not modelled 99.8 34 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
75d1i3za_



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76c2dm0A_



not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
77d1d4ta_



not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c1x6cA_



not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
79c2vifA_



not modelled 99.8 35 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
80d2izva2



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81d3c7ia1



not modelled 99.8 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
82c2ekxA_



not modelled 99.8 32 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
83d2cs0a1



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84c2h8hA_



not modelled 99.8 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
85c2c0iA_



not modelled 99.8 34 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
86c2hmhA_



not modelled 99.8 26 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
87d1cwea_



not modelled 99.8 40 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88d1fu6a_



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89d2eyva1



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
90d2shpa3



not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91d2fcia1



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
92c2dcrA_



not modelled 99.8 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
93c3mazA_



not modelled 99.8 17 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
94d1r1qa_



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c1g83A_



not modelled 99.8 35 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
96c2c9wA_



not modelled 99.8 27 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
97c2ci8A_



not modelled 99.8 29 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
98d1jyra_



not modelled 99.8 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
99c3or8A_



not modelled 99.8 29 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
100c2izvA_



not modelled 99.8 24 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
101d1mila_



not modelled 99.7 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
102c2el8A_



not modelled 99.7 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
103c2kk6A_



not modelled 99.7 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
104d2c9wa2



not modelled 99.7 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105c2cr4A_



not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
106d1xa6a2



not modelled 99.7 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
107c2dx0B_



not modelled 99.7 36 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
108c3gxxB_



not modelled 99.7 25 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
109d1rpya_



not modelled 99.7 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
110c2xp1A_



not modelled 99.7 18 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
111c1rqqC_



not modelled 99.7 22 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
112c2eyzA_



not modelled 99.7 30 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
113c3qwxX_



not modelled 99.7 25 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
114c2dvjA_



not modelled 99.7 36 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
115c2eyyA_



not modelled 99.7 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
116c3qwyA_



not modelled 99.6 25 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
117c2v1yB_



not modelled 99.5 73 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha;
PDBTitle: structure of a phosphoinositide 3-kinase alpha adaptor-2 binding domain (abd) in a complex with the ish2 domain3 from p85 alpha
118d1uura3



not modelled 99.4 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
119c2kt1A_



99.4 100 PDB header:protein binding
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: solution nmr structure of the sh3 domain from the p85beta2 subunit of phosphatidylinositol 3-kinase from h.sapiens,3 northeast structural genomics consortium target hr5531e
120d1phta_



not modelled 99.3 51 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain

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Transmembrane helix prediction 

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