Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ8IR23
DateTue Jan 22 11:23:02 GMT 2013
Unique Job IDb35f2fb588505824

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3bxjB_
Top template information
PDB header:signaling protein
Chain: B: PDB Molecule:ras gtpase-activating protein syngap;
PDBTitle: crystal structure of the c2-gap fragment of syngap
Confidence and coverage
Confidence:100.0% Coverage: 36%
343 residues ( 36% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
854 residues ( 90%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MADLIHLGNIDVVIQKDKPGSPTGCSDDGNLAGLGGMTGLGGIMAPGGIDLGDLAQELDH
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Disorder  ???????








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   .........70.........80.........90.........100.........110.........120
Sequence  DEFDGPHMLNGERPAIIAPPESEWYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYV
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   .........130.........140.........150.........160.........170.........180
Sequence  LSYYGRTGINHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRERLAIPVAPPEPV
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   .........190.........200.........210.........220.........230.........240
Sequence  NDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFRELVDD
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   .........250.........260.........270.........280.........290.........300
Sequence  LDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGPGSFLVRPSDNSPGDYSLFFHINNQIQRF
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   .........310.........320.........330.........340.........350.........360
Sequence  RIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAE
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   .........370.........380.........390.........400.........410.........420
Sequence  KIYATLRECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPK
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   .........430.........440.........450.........460.........470.........480
Sequence  KTKPKGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSL
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   .........490.........500.........510.........520.........530.........540
Sequence  KAQCDSQLSRAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKI
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   .........550.........560.........570.........580.........590.........600
Sequence  APEPVWEEEFVLDDVPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQL
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   .........610.........620.........630.........640.........650.........660
Sequence  TGMTPMGEWGSLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLAT
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   .........670.........680.........690.........700.........710.........720
Sequence  ALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAV
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   .........730.........740.........750.........760.........770.........780
Sequence  SETVQRILESKQSAELNPTKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFIC
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   .........790.........800.........810.........820.........830.........840
Sequence  SCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVA
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   .........850.........860.........870.........880.........890.........900
Sequence  KCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNL
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   .........910.........920.........930.........940.........950....
Sequence  NSQDTGRELATLHHICVSHSQELHELSNILSIKKLVTVTDMLTKHKLKYREMIS
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3bxj chain B

3D model

Region: 591 - 945
Aligned: 343
Modelled: 355
Confidence: 100.0%
Identity: 24%
PDB header:signaling protein
Chain: B: PDB Molecule:ras gtpase-activating protein syngap;
PDBTitle: crystal structure of the c2-gap fragment of syngap

Phyre2

PDB 1wer chain A

3D model

Region: 624 - 949
Aligned: 318
Modelled: 326
Confidence: 100.0%
Identity: 49%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: p120GAP domain-like

Phyre2

PDB 3fay chain A

3D model

Region: 626 - 943
Aligned: 314
Modelled: 314
Confidence: 100.0%
Identity: 17%
PDB header:membrane protein
Chain: A: PDB Molecule:ras gtpase-activating-like protein iqgap1;
PDBTitle: crystal structure of the gap-related domain of iqgap1

Phyre2

PDB 1nf1 chain A

3D model

Region: 630 - 946
Aligned: 255
Modelled: 267
Confidence: 100.0%
Identity: 27%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: p120GAP domain-like

Phyre2

PDB 2b3o chain A

3D model

Region: 83 - 351
Aligned: 205
Modelled: 206
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 80 - 347
Aligned: 199
Modelled: 199
Confidence: 100.0%
Identity: 32%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 3ps5 chain A

3D model

Region: 83 - 343
Aligned: 197
Modelled: 198
Confidence: 100.0%
Identity: 30%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2oq1 chain A

3D model

Region: 78 - 343
Aligned: 246
Modelled: 248
Confidence: 100.0%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 4fl2 chain A

3D model

Region: 78 - 401
Aligned: 303
Modelled: 305
Confidence: 100.0%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 2ozo chain A

3D model

Region: 78 - 343
Aligned: 246
Modelled: 248
Confidence: 100.0%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 3gqi chain B

3D model

Region: 81 - 355
Aligned: 206
Modelled: 207
Confidence: 100.0%
Identity: 31%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 1a81 chain E

3D model

Region: 84 - 343
Aligned: 206
Modelled: 207
Confidence: 100.0%
Identity: 26%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 2xp1 chain A

3D model

Region: 74 - 328
Aligned: 165
Modelled: 176
Confidence: 99.9%
Identity: 16%
PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6

Phyre2

PDB 3or8 chain A

3D model

Region: 84 - 328
Aligned: 163
Modelled: 166
Confidence: 99.9%
Identity: 18%
PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6

Phyre2

PDB 3hiz chain B

3D model

Region: 78 - 181
Aligned: 103
Modelled: 104
Confidence: 99.9%
Identity: 23%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2fo0 chain A

3D model

Region: 174 - 352
Aligned: 173
Modelled: 179
Confidence: 99.9%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 2abl chain A

3D model

Region: 186 - 342
Aligned: 151
Modelled: 153
Confidence: 99.9%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 1k9a chain B

3D model

Region: 178 - 348
Aligned: 170
Modelled: 171
Confidence: 99.9%
Identity: 24%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

PDB 2lqn chain A

3D model

Region: 244 - 411
Aligned: 167
Modelled: 168
Confidence: 99.9%
Identity: 17%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2gsb chain A

3D model

Region: 243 - 345
Aligned: 103
Modelled: 103
Confidence: 99.9%
Identity: 48%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2

PDB 2ysx chain A

3D model

Region: 36 - 180
Aligned: 107
Modelled: 107
Confidence: 99.9%
Identity: 32%
PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain

Phyre2

PDB 2cjt chain A domain 1

3D model

Region: 502 - 619
Aligned: 115
Modelled: 115
Confidence: 99.7%
Identity: 20%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 1gmi chain A

3D model

Region: 504 - 619
Aligned: 108
Modelled: 108
Confidence: 99.7%
Identity: 29%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 2fk9 chain A

3D model

Region: 504 - 619
Aligned: 108
Modelled: 108
Confidence: 99.6%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta

Phyre2

PDB 3m7f chain B

3D model

Region: 502 - 618
Aligned: 112
Modelled: 112
Confidence: 99.6%
Identity: 22%
PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex

Phyre2

PDB 2r09 chain A

3D model

Region: 355 - 484
Aligned: 124
Modelled: 123
Confidence: 99.6%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:cytohesin-3;
PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor

Phyre2

PDB 2d9z chain A

3D model

Region: 374 - 491
Aligned: 109
Modelled: 109
Confidence: 99.6%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:protein kinase c, nu type;
PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human

Phyre2

PDB 2dyn chain A

3D model

Region: 381 - 484
Aligned: 100
Modelled: 100
Confidence: 99.5%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2fjl chain A domain 1

3D model

Region: 381 - 486
Aligned: 100
Modelled: 100
Confidence: 99.5%
Identity: 17%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2coa chain A domain 1

3D model

Region: 381 - 484
Aligned: 95
Modelled: 95
Confidence: 99.5%
Identity: 22%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2cjs chain A domain 1

3D model

Region: 502 - 638
Aligned: 134
Modelled: 134
Confidence: 99.5%
Identity: 21%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 3kwt chain A

3D model

Region: 503 - 619
Aligned: 111
Modelled: 111
Confidence: 99.5%
Identity: 21%
PDB header:metal binding protein
Chain: A: PDB Molecule:munc13-1;
PDBTitle: munc13-1 c2b-domain, calcium-free

Phyre2

PDB 1v88 chain A

3D model

Region: 374 - 491
Aligned: 111
Modelled: 111
Confidence: 99.5%
Identity: 23%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2
1

c3bxjB_
2

d1wera_
3

c3fayA_
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d1nf1a_
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c2b3oA_
6

c2shpA_
7

c3ps5A_
8

c2oq1A_
9

c4fl2A_
10

c2ozoA_
11

c3gqiB_
12

c1a81E_
13

c2xp1A_
14

c3or8A_
15

c3hizB_
16

c2fo0A_
17

c2ablA_
18

c1k9aB_
19

c2lqnA_
20

c2gsbA_
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c2ysxA_
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d2cjta1
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d1gmia_
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c2fk9A_
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c3m7fB_
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c2r09A_
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c2d9zA_
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d2dyna_
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d2fjla1
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d2coaa1
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d2cjsa1
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c3kwtA_
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d1v88a_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3bxjB_



100.0 24 PDB header:signaling protein
Chain: B: PDB Molecule:ras gtpase-activating protein syngap;
PDBTitle: crystal structure of the c2-gap fragment of syngap
2d1wera_



100.0 49 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:p120GAP domain-like
3c3fayA_



100.0 17 PDB header:membrane protein
Chain: A: PDB Molecule:ras gtpase-activating-like protein iqgap1;
PDBTitle: crystal structure of the gap-related domain of iqgap1
4d1nf1a_



100.0 27 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:p120GAP domain-like
5c2b3oA_



100.0 29 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
6c2shpA_



100.0 32 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
7c3ps5A_



100.0 30 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
8c2oq1A_



100.0 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
9c4fl2A_



100.0 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
10c2ozoA_



100.0 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
11c3gqiB_



100.0 31 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
12c1a81E_



100.0 26 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
13c2xp1A_



99.9 16 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
14c3or8A_



99.9 18 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
15c3hizB_



99.9 23 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
16c2fo0A_



99.9 23 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
17c2ablA_



99.9 25 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
18c1k9aB_



99.9 24 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
19c2lqnA_



99.9 17 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
20c2gsbA_



99.9 48 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
21c1oplA_



not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
22d2oq1a1



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
23c2eobA_



not modelled 99.9 25 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
24c1x27F_



not modelled 99.9 25 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
25d2oq1a2



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
26c2y3aB_



not modelled 99.9 21 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
27c3nhnA_



not modelled 99.9 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
28d1a81a1



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29c2hdxB_



not modelled 99.9 24 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
30c1y57A_



not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
31d1a81e2



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
32c2h8hA_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
33c2eo3A_



not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
34d2fcia1



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35d1nrva_



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36d1pica_



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37c2c0iA_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
38c2eo6A_



not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
39d1a81a2



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40c2ysxA_



99.9 32 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
41d1a81e1



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d2shpa2



not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43d1fhsa_



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44c2dlyA_



not modelled 99.8 25 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
45c1g83A_



not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
46d1jwoa_



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d1csya_



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48c2ci8A_



not modelled 99.8 30 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
49d3c7ia1



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50c2crhA_



not modelled 99.8 16 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
51c2dlzA_



not modelled 99.8 18 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
52d1opka2



not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53c1ka6A_



not modelled 99.8 23 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
54d1k9aa2



not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d1rjaa_



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56c1x6cA_



not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
57d2izva2



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58c2augB_



not modelled 99.8 25 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
59c2lctA_



not modelled 99.8 17 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
60d1qada_



not modelled 99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61d2eyva1



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62d1lkka_



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63d1o48a_



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64d1i3za_



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65d1d4ta_



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66c2ge9A_



not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
67d1ayaa_



not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68d1blja_



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2dvjA_



not modelled 99.8 21 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
70d2qmsa1



not modelled 99.8 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d1bkla_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72c2kk6A_



not modelled 99.8 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
73c2eyyA_



not modelled 99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
74d1mila_



not modelled 99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75d1qcfa2



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1luia_



not modelled 99.8 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d1r1qa_



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c2hmhA_



not modelled 99.8 20 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
79d2shpa3



not modelled 99.8 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80c2knoA_



not modelled 99.8 29 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
81c2c9wA_



not modelled 99.8 22 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
82c2el8A_



not modelled 99.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
83c2dcrA_



not modelled 99.8 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
84c2eyzA_



not modelled 99.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
85d1f2fa_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86d1jyra_



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87d1g83a2



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88c2vifA_



not modelled 99.8 24 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
89d2cs0a1



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
90c2izvA_



not modelled 99.8 22 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
91d1xa6a2



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
92d1fu6a_



not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
93c2ekxA_



not modelled 99.8 24 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
94d1rpya_



not modelled 99.8 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c3mazA_



not modelled 99.8 15 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
96c3qwxX_



not modelled 99.8 18 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
97d1cwea_



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98c1rqqC_



not modelled 99.8 22 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
99c3qwyA_



not modelled 99.8 18 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
100c2dm0A_



not modelled 99.7 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
101d2c9wa2



not modelled 99.7 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
102c3gxxB_



not modelled 99.7 22 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
103c2cr4A_



not modelled 99.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
104d2cjta1



99.7 20 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
105d1gmia_



99.7 29 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
106c2fk9A_



99.6 31 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta
107c3m7fB_



99.6 22 PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex
108c3l9bA_



not modelled 99.6 13 PDB header:membrane protein
Chain: A: PDB Molecule:otoferlin;
PDBTitle: crystal structure of rat otoferlin c2a
109c2dx0B_



not modelled 99.6 32 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
110c2r09A_



99.6 23 PDB header:signaling protein
Chain: A: PDB Molecule:cytohesin-3;
PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor
111c2d9zA_



99.6 20 PDB header:signaling protein
Chain: A: PDB Molecule:protein kinase c, nu type;
PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human
112d2dyna_



99.5 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
113d2fjla1



99.5 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
114d2coaa1



99.5 22 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Pleckstrin-homology domain (PH domain)
115c1xa6A_



not modelled 99.5 31 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
116d2cjsa1



99.5 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
117c3kwtA_



99.5 21 PDB header:metal binding protein
Chain: A: PDB Molecule:munc13-1;
PDBTitle: munc13-1 c2b-domain, calcium-free
118d1qasa2



not modelled 99.5 17 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
119c2q3xA_



not modelled 99.5 25 PDB header:transport protein
Chain: A: PDB Molecule:regulating synaptic membrane exocytosis protein 1;
PDBTitle: the rim1alpha c2b domain
120c2nsqA_



not modelled 99.5 26 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein;
PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein

Binding site prediction 

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Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below