Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	Q	Q	V	I	I	F	D	T	T	L	R	D	G	E	Q	A	L	Q	A	S	L	S	V	K	E	K	L	Q	I	A	L	A	L	E	R	M	G	V	D	V	M	E	V	G	F	P	V	S	S	P	G	D	F	E	S	V	Q	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	A	R	Q	V	K	N	S	R	V	C	A	L	A	R	C	V	E	K	D	I	D	V	A	A	E	S	L	K	V	A	E	A	F	R	I	H	T	F	I	A	T	S	P	M	H	I	A	T	K	L	R	S	T	L	D	E	V	I	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	A	I	Y	M	V	K	R	A	R	N	Y	T	D	D	V	E	F	S	C	E	D	A	G	R	T	P	I	A	D	L	A	R	V	V	E	A	A	I	N	A	G	A	T	T	I	N	I	P	D	T	V	G	Y	T	M	P	F	E	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	I	I	S	G	L	Y	E	R	V	P	N	I	D	K	A	I	I	S	V	H	T	H	D	D	L	G	L	A	V	G	N	S	L	A	A	V	H	A	G	A	R	Q	V	E	G	A	M	N	G	I	G	E	R	A	G	N	C	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	E	E	V	I	M	A	I	K	V	R	K	D	I	L	N	V	H	T	A	I	N	H	Q	E	I	W	R	T	S	Q	L	V	S	Q	I	C	N	M	P	I	P	A	N	K	A	I	V	G	S	G	A	F	A	H	S	S	G	I	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	D	G	V	L	K	N	R	E	N	Y	E	I	M	T	P	E	S	I	G	L	N	Q	I	Q	L	N	L	T	S	R	S	G	R	A	A	V	K	H	R	M	D	E	M	G	Y	K	E	S	E	Y	N	L	D	N	L	Y	D	A	F
Secondary structure
SS confidence
Disorder												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	K	L	A	D	K	K	G	Q	V	F	D	Y	D	L	E	A	L	A	F	I	G	K	Q	Q	E	E	P	E	H	F	R	L	D	Y	F	S	V	Q	S	G	S	N	D	I	A	T	A	A	V	K	L	A	C	G	E	E	V	K	A
Secondary structure
SS confidence
Disorder							?	?	?																?	?	?	?	?													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		E	A	A	N	G	N	G	P	V	D	A	V	Y	Q	A	I	N	R	I	T	E	Y	N	V	E	L	V	K	Y	S	L	T	A	K	G	H	G	K	D	A	L	G	Q	V	D	I	V	A	N	Y	N	G	R	R	F	H	G	V	G	L
Secondary structure
SS confidence
Disorder				?	?																													?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.
Sequence		A	T	D	I	V	E	S	S	A	K	A	M	V	H	V	L	N	N	I	W	R	A	A	E	V	E	K	E	L	Q	R	K	A	Q	H	N	E	N	N	K	E	T	V
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1sr9 chain A Region: 1 - 499 Aligned: 485 Modelled: 493 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of leua from mycobacterium tuberculosis Phyre2 PDB 3ivu chain B Region: 1 - 381 Aligned: 362 Modelled: 377 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: B: PDB Molecule:homocitrate synthase, mitochondrial; PDBTitle: homocitrate synthase lys4 bound to 2-og Phyre2 PDB 3hpx chain B Region: 1 - 326 Aligned: 322 Modelled: 326 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of mycobacterium tuberculosis leua active site2 domain 1-425 (truncation mutant delta:426-644) Phyre2 PDB 2zyf chain A Region: 3 - 329 Aligned: 311 Modelled: 327 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:homocitrate synthase; PDBTitle: crystal structure of homocitrate synthase from thermus thermophilus2 complexed with magnesuim ion and alpha-ketoglutarate Phyre2 PDB 3ble chain A Region: 4 - 323 Aligned: 302 Modelled: 310 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans; PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate Phyre2 PDB 1sr9 chain A domain 2 Region: 1 - 291 Aligned: 287 Modelled: 291 Confidence: 100.0% Identity: 27% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: HMGL-like Phyre2 PDB 1nvm chain G Region: 2 - 362 Aligned: 320 Modelled: 330 Confidence: 100.0% Identity: 22% PDB header:lyase/oxidoreductase Chain: G: PDB Molecule:4-hydroxy-2-oxovalerate aldolase; PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate Phyre2 PDB 2ftp chain A Region: 1 - 290 Aligned: 278 Modelled: 286 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of hydroxymethylglutaryl-coa lyase from pseudomonas2 aeruginosa Phyre2 PDB 1ydo chain C Region: 1 - 297 Aligned: 280 Modelled: 297 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: C: PDB Molecule:hmg-coa lyase; PDBTitle: crystal structure of the bacillis subtilis hmg-coa lyase, northeast2 structural genomics target sr181. Phyre2 PDB 3ewb chain X Region: 3 - 276 Aligned: 269 Modelled: 274 Confidence: 100.0% Identity: 51% PDB header:transferase Chain: X: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of n-terminal domain of putative 2-2 isopropylmalate synthase from listeria monocytogenes Phyre2 PDB 3eeg chain B Region: 3 - 279 Aligned: 272 Modelled: 274 Confidence: 100.0% Identity: 53% PDB header:transferase Chain: B: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of a 2-isopropylmalate synthase from2 cytophaga hutchinsonii Phyre2 PDB 2cw6 chain B Region: 1 - 284 Aligned: 272 Modelled: 284 Confidence: 100.0% Identity: 26% PDB header:lyase Chain: B: PDB Molecule:hydroxymethylglutaryl-coa lyase, mitochondrial; PDBTitle: crystal structure of human hmg-coa lyase: insights into2 catalysis and the molecular basis for3 hydroxymethylglutaric aciduria Phyre2 PDB 3bg5 chain C Region: 2 - 421 Aligned: 410 Modelled: 420 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: C: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of staphylococcus aureus pyruvate2 carboxylase Phyre2 PDB 1nvm chain A domain 2 Region: 1 - 299 Aligned: 274 Modelled: 285 Confidence: 100.0% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: HMGL-like Phyre2 PDB 1rqb chain A domain 2 Region: 1 - 296 Aligned: 275 Modelled: 271 Confidence: 100.0% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: HMGL-like Phyre2 PDB 1rr2 chain A Region: 1 - 296 Aligned: 276 Modelled: 282 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid Phyre2 PDB 1ydn chain A Region: 2 - 278 Aligned: 265 Modelled: 269 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of the hmg-coa lyase from brucella melitensis,2 northeast structural genomics target lr35. Phyre2 PDB 2nx9 chain B Region: 3 - 363 Aligned: 307 Modelled: 316 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:oxaloacetate decarboxylase 2, subunit alpha; PDBTitle: crystal structure of the carboxyltransferase domain of the2 oxaloacetate decarboxylase na+ pump from vibrio cholerae Phyre2 PDB 3dxi chain B Region: 5 - 306 Aligned: 278 Modelled: 291 Confidence: 100.0% Identity: 19% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative aldolase; PDBTitle: crystal structure of the n-terminal domain of a putative2 aldolase (bvu_2661) from bacteroides vulgatus Phyre2 PDB 3bg3 chain B Region: 2 - 296 Aligned: 273 Modelled: 281 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase, mitochondrial; PDBTitle: crystal structure of human pyruvate carboxylase (missing2 the biotin carboxylase domain at the n-terminus) Phyre2 1 c1sr9A_ 2 c3ivuB_ 3 c3hpxB_ 4 c2zyfA_ 5 c3bleA_ 6 d1sr9a2 7 c1nvmG_ 8 c2ftpA_ 9 c1ydoC_ 10 c3ewbX_ 11 c3eegB_ 12 c2cw6B_ 13 c3bg5C_ 14 d1nvma2 15 d1rqba2 16 c1rr2A_ 17 c1ydnA_ 18 c2nx9B_ 19 c3dxiB_ 20 c3bg3B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499