>ss_pred
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCHHHCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCEEEEEEEECCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCEEEEEEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
>ss_conf
9854899975888655277864789999999999997799899973446885889999999840699789999627713489999999857996999982189789988858998999999999999999679659997652667998999999999995599899982875668989999999999985667677379999548877407999999873974987401011853477558999999984036666667889899999999999993789987887325722212100638987315674575586785987039998755577999999998299998899999999999875202333526789998876301235623667888632888842389999989969999854686489999999986189828999999842788750799999998699799999823638999999999999999764212411001210024322459
>batch____
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
>UniRef50_Q9LPR4(89-655:675) 2-isopropylmalate synthase 1, chloroplastic n=39 Tax=cellular organisms RepID=LEU11_ARATH  E=1e-100 s/c=0.65 id=47% cov=94%
----VRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAETVGNTvdengyvpVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKKTKAEVIEIARSMVRFARSLgCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTINGIGERAGNASLEEVVMAIKCRGDhvLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAFAHESGIHQDGMLKHKGTYEIICPEEIGLersNDAGIVLGKLSGRHALKDRLTEvhsnlthtntciaifvgdtnvllsfvhfqLGYQLDDEQLSTIFWRFKTVAEQKKRVTDADI--IALVSDEVFQPEAvWKLLDIQITCGTLGLSTATVKLADADGKEHVACSiGTGPVDSAYKAVDlivkvlfiplRLSSTNnspepATLLEYSMNAVTEGIDAIATTRVLIrgsnKYSStnaitgeevqRTFSGTGAGMDIVVSSVKAYVGALNKM------------------------
>UniRef50_Q2RGA1(1-508:533) 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA   E=2e-48 s/c=0.39 id=34% cov=91%
MAEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLR-AREViwRQARLVAFGR-TRKPGQAAAEDANLLAIKRAGVKVATifgksWDLHVTAALGTTLAEnlamIGDSVAFLVDQGLEVIYDAEHFFDGFKANPDYAL-ETLKAAAKAGASWIVLCDTNGGCLPWEIEEAVA----RVRQEIQVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTINGFGERCGNADLCSVMpnLELKMGYQCLPPGQLAFLTEV---SRYVSEIANVVPAGNQPFVGYSAFAHKGGIHVSAVLKAPDTYEHIRPQQVG-NERRVLMSDQAGASNLRCKAEEMGLELNPERERGIIEGIKELERQGYQFEGADASLELFLRKTTgEYRQQFEVEYVKAlvekRAGQEAISEAIVKLRVGDQVVHTAAEGNGPVNAmdnalrkaleeVFPAIRhmRLTDYKVRVLD-----EKDATSARVRVLIESRDGSNSWNTVGVSTNIIEASWEALL------------------------------
>UniRef50_D1AJT6(3-510:529) 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE  E=9e-47 s/c=0.37 id=32% cov=91%
---KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGSNPKDLEFFELVkSVELKHSKLVAFGSTRRKDVapeeDQNLISLLQAGTEYVSIFGKSWDFHVTDIIKTTLEnnlEMIKDTLLFLKsKGKKVIFDAEHFFDGYKNNPEYAL-EALKAAKDGGAEILTLCDTNGGCFPEEISRITKEVKEKLGDIK---IGIHAHNDMGFGVANSIAAVEAGALQVQGTFLGYGERCGNANLSTIIANLQLKKD----YELVPREKlglLTSTARIIAEISNITIEDSMPYIGKNAFAHKGGMHIDGVSKASHSFEHINPELVG-NEREFLLSEVSGRSTILeeiRRVDKDIQRDSEATAGII--ERLKELEYQGYQFEgakatFELVIRKYLGKYK---PFFDLVYFDVKGnyiGKKYYSTAVVKVKVKDQIELTVAEGDGPVNALDQALRIALERfypelkEMHLIDYKVrVLKGEENATASKVRVLIESADAKnsWTTIGVSTDIIEASWIALV------------------------------
>UniRef50_Q02CM5(2-508:536) 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE  E=4e-43 s/c=0.35 id=32% cov=91%
---KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFaRSGELNLKHSKLTAFGSTrfaknpVEEDRNVKA--LVEAGTPVVSIFGKSWDLHVRRALGISLEEnlvlISDTVGYIHGHGREVVYDAEHFFD--GYTADPDYAlRTLEAAHKAGASVLCLCDTNGGTVTGRLVEIVAEVRKRF----DGIIGIHTHNDGDLAVANTIAAVEAGATHVQGCMNGYGERCGNANLASVIANLELKLG----HTTVGPEKlagLSSTCRFIAELANLPLRNDQPFVGKSAFAHKGGVHVSAVLKDSATYEHIKPEAVG-NRQRVLVSDLSGRGNIIYKLKQHGLADRlEEDTRRVLLERIKQMEYEG----YELEAAeGTFELLVREALHPGMHFFDVESyevstraagNAASHSTATVTLKSQDGVHSATETGHGPFDALQVCLRKCLSklypqiVDVRLTDYKVRVLDTNKGTAANVRVLIEWSDHRrsWSTVGVSDNVIEASWKALV------------------------------
>UniRef50_C3NF24(31-535:553) 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN  E=9e-42 s/c=0.34 id=30% cov=92%
--KSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGSNPKDEEFFKEIKKyKLSKARIAAFGSTKRKDVsvkeDISLNSIIKADVDFAVIFGKSWSLHATEVLKVTkqdnLDIIYDSINYLRSHGLKVIFDAEHFYQGFKEDPKYAL-EVVKTAESAGADVIALADTNGGTPPFEVYEIT----KKVREVLHVKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGERTGNADLIQIIptLVLKMGFNVLKGRDSL--RKLREVSRIVYEILGLPPNPYQPYVGDNAFAHKAGVHVDAVMKVPRAYEHVDPLLVG-NDRKFVISELSGTANLVSYLQGIGIVVDKKD-ERLKKALNKIKELETKGYSFDVGPASAILITLKElnmyTNYINLEYWKVINENNGLSIGIVKVNS----QLEVAEGVGPVNAIDRALRmalqrvypEISE--VKLIDYRVILPSEVKNTESVVRVTIEFtdNKMNWRTEGVSKSVVEASVMALVDGLD--------------------------
>UniRef50_A4A2P3(2-514:542) 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN  E=4e-41 s/c=0.33 id=32% cov=91%
--RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGYPLSNEKDaeyFRRVQDL--NLKHTKVCAFGMTRRKGINAAddpgMQALVSSGAPVVTIVGKTHDFHVTDVLRVTLEEnlamIADSVAYIVGAGREVIYDAEHFFDGWKANP-EYAAETIRAAAKAGARMVVMCDTNGGSLPEEIAEYAAKAIAALTEFN-VPVGIHTHNDGDLAVANSLAAVDAGAVQVQGTINGFGERCGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNRRNNQAFVGQSAFAHKGGMHVHAINRAASSYEHIDPQSVG-NERRVLVSELSGRSNIvalttKHNLQddrelmdkilaEVVAKENQgFQFEAAEASFDLLVKRVAGVFEPHFEILKYHVEVEDLVEHKMVDL---------VTEATVKVSVDGEIRYEVGEGDGPVQALDVALRKslngcfPTLEEMHLVDYKVRVVNQeaGTAARIRVTIESADENDVWGTIGVSENIIQASWNALV------------------------------
>UniRef50_B9KY22(30-540:562) 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP  E=8e-41 s/c=0.33 id=33% cov=92%
--RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDmafFERARH--QQWRHARITAFGStrraggTVEEDVNL--RLLLEAETPAVTIVGKASPFQVRVILGTTLDEnlrmVAESVAFLKAAGREVIFDAEHFFDGYAEDPDYALA-VLRAACDAGADAVVLCDTNGGTLTDPLVRAVRHALSSV----SCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTMNGLGERIGNANLCSIIPILEYKLGYRCLPPG-NLRKLTETSRYVAEVANLAHDPRLPFVGAFAFTHKAGLHVNAIAKHPSAYEHIPPEVVG-NTRHVLVSELSGRSniVVKARSFGIELGDKPEVVRRVLEQIKEL-EFHGYWFedaDASLELLIRRNLPDYRPPFEVLDYTVLteyRNGRGMLAEAMVKLRIGQHVFHTAAEGNGPVNALDRATRKalqefypeIAAVDLEDYKVRVLDDHHGTGAKVRVWIRSGDAHGSWNTVGSSENIIEASWLALADSL---------------------------
>UniRef50_B2UP78(1-466:544) 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8  E=2e-40 s/c=0.36 id=32% cov=84%
MSTKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFNAMrGVGLRNAKLAAFGSTHHpshtPETDPTLTALISSGARVAAVFGKSCPRHVEVALgisRERNLEIIGNSIsFLKKNMEEAFFDAEHFFDGFKRDQEYALA-VLRTAWEHGADCLVLCDTNGGTMPEEISSIIRTVRERLPH---ALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNGIGERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNAAFAHKGGVHVSAIMKEAALYEHIDPSLVG-NAQRVLMTEQGGRSNILSLSRTLGFELEKG--DPLLDV-LSAAVKKNAALGYDYVAapasaeLLFL---RHMPDNALKPYFNIlrtvvltsrhEMDPDMMVEASLKLDVHGNVEHTAAGGFGPVHALDRALRRaLTRWYPELEQMHL------------------------------------------------------------------------
>UniRef50_A5VPL4(107-624:640) 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2  E=7e-40 s/c=0.32 id=32% cov=93%
--ERIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFKR--RQTARAKFVAFGMTKRAGVSVSNDpglsSLLQASADAV-CFVAKSwDYHVRLALGCTNEENLESITASVTAARMAGREALVDCEhffDGYKAnPEYALA-CAKAAYSAGARWVVLCDTNGGTQPLEVAAIVEAVKAVVPGES---LGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIGERCGNANLVSLIPTLVLKPYWaerfeLGIKPA-SLKSITRISRAFDDILNRPATEQAPYTGTSAFATKAGIHASALMKEPQTYEHIPPESVG-NSRRVMVSDQGGKSNFIAELERRGIRvaKDDVRLDTLI-ALVKEREAEGYAYegaDASFELLAR-GMLNPQPEFFKVEsfrclverRFDANGMLKTVSEAVVKVEVDGEMHMSVAEGHGPVNALDIALRKDLGCfqaeieDLELVDFKVRILNGGTAAITRVLIeSGDATGARWRTVGVSDNIIDASFQALMDSVN--------------------------
>UniRef50_C6VV54(3-505:520) Pyruvate carboxyltransferase n=32 Tax=Bacteria RepID=C6VV54_DYAFD   E=2e-39 s/c=0.33 id=30% cov=94%
-SRYIEIMDTTLRDGEQTSGVSFSASEKLTIAqILLQEVKVDRIEVASARVSEGEFQAVKKITDWAgANGFLDKIEVLTFVDGDASINWMVQAGARVMNLLTKGSLNHLTHQLKKSPEAHFEDIRNVVELAEKNGIQCNVYLEDWSngmRSSKEYVFQSLDFLSTLPVKRILLPDTLGILTPFESYTFIKEIVDRYPD---QHFEFHGHNDYDLGVANVMEALRAGVQGLHLTVNGMGERTGNAPLASTIAVI---NDLMpECTTAVNEKSLYSISKLVETFSGIRIPANKPIVGESVFTQTAGIHADGDKKNNLYFSKLMPERFGRQRL-YALGKTSGKANIENNLRDLGISLSDADLKKVTQRIIELGDRKEVVTPEDLPyIISDILDSDAIEEKVVITNYVLTHSKNLKPSATLQISFGEEVFEENAQGDGQYDAFMNALKKIyKKKGIElpmLSDYTVRIPPGGKtDALCETIITWEINGKEIKTRGLDSDQTFSAIKATQKMLNLI------------------------
>UniRef50_C9RN88(2-446:535) 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS  E=8e-38 s/c=0.36 id=30% cov=82%
---KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIEGGWPnPSNPTDEEFFKLIKDvKLKHAKIAAFGSTRRPGIlpenDPLLQALIKSEAPVKTIFGKSWDLHVTDVIRTTLEENLDMIESSVAYLKEHSEEVIYDAEhffDGYKANPEYALETLKAAELGHADCIVLCDTNGGTMPWEIEEIVKKVQTRI----STPLGIHVHNDSGLAVANSIYAVKAGCVMVQGVVNGYGERCGNANLTTIAADLKFKMD-RDFAAAKKLSHLRQLSGNIDQIVNLPSDVHAPYVGDAAFAHKGGAHIDGVMKVSRSFEHIDPHSVGNDRVFVTSDQAGGSLVVeKLKAIKPGIDKKDPVVASLLKE-IKERENAGWHFDsaeasFKLLVYRHLGMVKEP---FKvLNYRVIEDKTPqgvSVSQATVKLQVGDKISHQVSEGDGPVNALDAALRK-------------------------------------------------------------------------------------
>UniRef50_B3TC58(13-519:530) Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ  E=4e-37 s/c=0.31 id=29% cov=92%
------ILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPKDLEFFKLIKKhELRNSKIAVFGSTRRKNITAKNDnNLKVmvdSEALVSVIVGKTSSFHVEKILNCSLEDNLEmiydSLIFLRESGLQTYFDAEHFFDGYNINPEYAI-QTVKTAEEAKVNTIVLCDTNGGMLPHQIERVV----KKIKKNSEVKIGFHGHNDTGCAVANTVSAVVAGATHIQGTINGLGERTGNADLCQVIpnLEMKLKKKTRNIQKKqiINFGKLRDISNYINELVNINSFDHQPYFGKFAFSHKAGLHVDGMLKSSKAYEHINPE-IFKSERSFTISELSGKAniiALSKKFNFQIDKDDKRIIDILEE--IKKLEFSGFTLD-NADAttyLIFLRHLGLYKQYFHVDSWKVLTeKQNQInSKSEIKILIGENIYTNNAYGVGPVNSLAIALrkslqNKYPEINkIELTNYKVSIVGASKDTASLVRVFIEFKKDEVVWATTATsqNILDASLRALI------------------------------
>UniRef50_Q3M862(6-559:577) 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT   E=4e-37 s/c=0.29 id=32% cov=93%
-SPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPGANPKDVQFFWQLQEDpLKLSQIVAFCSTRRPHTHAADEPMlqdiLAAGSSWVTIFGKSWDLHVTTGLKTTLEEnlaMIRDTIeFFRSQGRRVIYDAEHWFD--GYKHNRDYAlQTLKAAMAAGAEWLVLCDTNGGTLPHEVSQIVQDVVKvtrdwgrinskldqsgqvvseevekstnslpntqyPIPNLPFPIpqIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLIPNLQLK---LGYSCITEHQlgQLAEASRFVSEVVNLAPDEHAPFVGRSAFAHKGGIHVSAVERNPLTYEHIQPEQVG-NRRRIVISEQSGISNVLAKARTFGIEldkqtpEAKQILQR-----LKELESEGYQFEAAEASFALLmyealgGRQQfFEVKGFQVHCDLVEGKEMTNALATVKVAVNGKNILEAAEGNGPVAALDAALRKaLVNFYPQLATFELTdykvriLDGHTGTSAKTRALVESGNGyQRWTTVGVSPNILAASYQAVVEGL---------------------------
>UniRef50_P74269(8-525:547) Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3  E=5e-37 s/c=0.31 id=30% cov=91%
------LYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQLQEEpLEQAEIVAF--CSTRRPHKAVETDKMLQAIlsagtrWVTIFGKSWDLHVLEGLQTSLAEnlamISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQ-QAGAEWLVMCDTNGGTLPGQISEIttkvrrslgLDGQSDRQPQ-----LGIHAHNDSGTAVANSLLAVEAGATMVQGTINGYGERCGNANLCTLIPNLQLKLDYDCIEPeKLAH--LTSTSRLISEIVNLAPDDHAPFVGRSAFAHKGGIHVSAVQRNPFTYEHIAPNLVG-NERRIVVSEQAGLSNVLSKAELFGIALDRQNPAcRTILATLKDLEQQGYQFEAAEASFELLMRQAmgDRQPLFLVQGFQVhcdlltpaENPAYRNALATVKVTVNGQNILEVAEGNGPVSALDQALRKaLTRFYPQIADFHLTdykvrilDGGAGTSAKTRVLVESSNGDRRWTTVGVSGNILEASYQAVV------------------------------
>UniRef50_D2QST1(8-505:506) Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI  E=6e-36 s/c=0.31 id=31% cov=90%
------IMDTTLRDGEQTSGVSFSASEKLALAqLLLTEVKVDRVEIASARVSAGELEAVQQITRWADS---IGLIDKVEvltfVDGQASLDWLQASGAKVMNLLTKGSLNHLTHQLKKTpgehftdIGQVVCAAGKLGVKANVYLED----WSNGMRNSPDYVFQYLDFLNTQPILRVLLPDTLGVLTPAESYSFVHQLVTRYPNLH---FDFHAHNDYDLSIANVMEAIRAGAHGIHLTVNGLGERAGNAPLAS---AIAVLRDFMpEVRTGVVEKSLYQVSKIVETFSGLRIPDNKPVVGDNVFTQTAGIHADGDKKNNLYFNALLPERFGRKR-SYALGKMSGKANIENNLRELGIQLSEDDLKKVTQRVIELGDQKEVVTRED---LPYVISDVLNTNSFasRVEVLNyVLTHSKDLkPSATLRVRIDEEHFEESAQGDGQYDAFMNALKKIyvkkkltlpllTDYAVRI------PTGGRTDALCETIITWKHKNGEFKTRGLDSDQTVSAIKATQKMLNTL------------------------
>UniRef50_O86511(13-517:534) Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO  E=4e-34 s/c=0.30 id=31% cov=91%
------VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEIdfKHAQLVAFGSTRRAGAN-AAEDHQVKALLdsgaQVITLVAKShDRHVELALRTTLDENLAMVADTVSHLKAQGRRVFVDCEhffDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGMLPAQIQAVVATVLADT----GARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANLFPVVAALELKygKQVL---PEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVG-NTMRMLVSDMAGRASIELKGKELGIDLGG-DRELVGRVVERVKERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESwraitedrpdGSH-ANEATVKLwAKGERIVA-TAEGNGPVNALDRSLRVALEKiypelaKLDLVDYKVrILEGvHGTQSTTRVLISTSDGTGEWATVGVAENVIAASWQAL-------------------------------
>UniRef50_A0LSS5(19-523:554) 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=A0LSS5_ACIC1   E=8e-34 s/c=0.29 id=30% cov=90%
------VYDTTLRDGAQGEGMALTVADKLAIARHLDDLGVGFIEGGWPGALPKDTEFFRRARTEltLRNAVLVAFGATRKPESRVEADpqvlALLEAETPAVCLVAKSHVRHVSEALRTSLDEnlamIRDTVAFFRREGRRVFLDAEHFFDGYAADPQYAV-ECVRVAAESGAEVVVLCDTNGGMLPPRIADVVHEVAERtgVP------LGIHCHDDTGCAVANTLAAVDAGVVQVQGVVNGYGERCGNANLITVVanLELKMGRRVL---PPGRLAELGRVSHAIAEVANQPPRANQPYVGLSAFAHKAGLHASAIKVSPDLYQHIDPALVG-NDMRMLVSEMAGRASVELKSRQLG-----FDLSGQRDAVSRIVERvknlEARGFMFEAADASFELLLREELDGVPTRFFDLESWrviverradGEVVSEATVKVVVKGERIVATAEGNGPVNALDRALRQALERlypqlaELELVDYKvrILDGSHGTGAVTRVLIETSDGETEWTTIGVDGNVISASWQAL-------------------------------
>UniRef50_C0W2B6(3-542:551) Alpha-isopropylmalate/homocitrate synthase family transferase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W2B6_9ACTO  E=2e-31 s/c=0.26 id=31% cov=93%
LTPRVATYDTTLRDGAQQQSVSFTVEDKLAVARILDHLGVTYIEAGWPGAIPKDTEffaraaselSLAT-ARLVAFGSTCHPGTAAEKDPQL--RGLLDSGAPVITIVAKSDPAHVERALRTSGEEnlrmVADSVGLLVAAGREVMVDLEHYVDGVARDPRYGIELALTAA-RAGASAVIPCDTNGGSLPGTVAAEISRLRAALdaAGHEDCVVGIHTHDDSGLAVAAAMAAVEAGARQVQGCVNGFGERTGNANLLTLIANLELKTGYQALagdsqERARRLAELSAVSRTVGEIANRAPSGRLPYVGSKAFAHKAGLHASAIKVDPNLYQHVDPARVG-NTMTMLVSEMAGRASIELKARELGIETgGDKELLARVTEVVKGREAAGYAYDAADGSFELLLRQAlgQLPQYFRVESWRASVTARpaagqeilpeDGATvtdseATVRMWVGGRRLAVLGEGNGPVnaldhalcDALATAYPEIRAFELTDFKVRILDSERGTHAIVRVLIDITDGERSWSTVGVGTDIIEASWEAL-------------------------------
>UniRef50_Q0EZI5(8-517:543) 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT  E=3e-31 s/c=0.27 id=30% cov=90%
--RRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASPTDdcfFELMRD--RAWSHSRLVAFGSTARPghpaSEDPGLARLVACGADAVCIFGKSWDLHVTTglgiDLQTNLDLVRESVAWL----KLHVDTVLFDAEHFfdGYAANRDYAmQVLAAAADAGADSLVLCDTNGGSLPEQIGACVRQVVARYPDL---TIGIHAHNDSEMAVANAVSAVSAGASHVQGTINGLGERCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFVGQNAFAHKGGIHVSAVRKASHLYEHIDPASVG-NAQRVLVSNQAGRSNILAKLQQL---EPDAIVDDaaVVRAVqrIKEMEATGYAFEGADASFQLLLRRAtgQFRRHFELVSFRVydeKRGHDEApeSEATVQVRVNGRLLHTAALGSGPVNAMDKALRaaltgaypgledmRLTDFKVRV----LSTKDATEAAV-RVLIESSDGVRKWNTVGVSTDVLEATYRAL-------------------------------
>UniRef50_Q97MC5(35-553:558) 2-isopropylmalate synthase n=50 Tax=Bacteria RepID=LEU1_CLOAB   E=4e-29 s/c=0.25 id=29% cov=90%
-----------LRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLIEDkliPEDVTIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVKSLAIkgaQMVKKYSEYTEYseskfvFEYSPESFTGTELDYALEVCEAVLNVWKPSkenkaiINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADRVEGTLFGNGERTGNLD----IMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHERHPYAGKLVFTAFSGSHQDAIrkglksLKEGKNkhwevpYLAVDPHDLGREYEEiIRINSQSGKGGTAYIM------ESDFGFilpKAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLENRSPYYlknykihsiqNIEEEKNTVDIEAVISVNGKDTSIEGV-GNGPVDAFFNAMNNKKYNGCKFISYdehALNIGSHSK-AVAYVQIES--QDKKYFGVGISDNIDTASINAIVSALN--------------------------
>UniRef50_B7G5N8(7-511:581) 2-isopropylmalate synthase n=2 Tax=Bacillariophyta RepID=B7G5N8_PHATR  E=9e-29 s/c=0.26 id=29% cov=83%
------------RDGTQGESVSASVDDKLKITRRLVAFGVDFVEAGWPGSNPKDaafFTRAKTDLTHAERDKLVAFGSTRRKRVraneDPQVQALLESQAPTVCIVAKAHAWQVTEILRATLDEnldmIRDTVACLVAHGRVVMVDLEHALDGYATDPDY-VHACCRAAVDGGASVLVACDTNGGTMPWRVGTVVRELVDTY-GPQGVTIGMHAHNDCGMAVANSLTAAQYGAGLIQGTVNGIGERTGNADLCAIVpsLALHVQAQL---HCRASLATLTSLSRFVDEVLNQTPNHAAPFVGSSAFAHKGGLHVAAMERSPLSYQHIEPELVG-NEQRILISELSGRQNILGKMQQAGVDlgtsgsdravailnrvktleaqgytfegaEASVHLMILhatkgYCPPFQVLDYSAQVYDANIDSATRVLRHTESPDTDPTDSKKPRkaPGFGPTARATVNVRTMRPIedglesylanlspyqdRLEVSDGNGPVDALANALMRALQpvhpilQHVELVDYKV------------------------------------------------------------------------
>UniRef50_A4QAP0(74-609:616) 2-isopropylmalate synthase n=225 Tax=cellular organisms RepID=LEU1_CORGB  E=2e-27 s/c=0.24 id=29% cov=93%
-----------LRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKdmiPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATdaaELIKTiAQDYPDTnwrWQYSPESFTGTEVEYAKEVVDAVVEVMDPTpenpmiINLPSTVEMITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGERTGNVCL--VTLALNMLTQ--GVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYAGDLVFTAFSGSHQDAVnkgldamaakvkpganstdvsweeLRDTEwevPYLPIDPKDVGRDyEAVIRVNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSAVVQnVTDAEGGEVNskamWDIFATEYL-ERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVD-GHGNGPLAAYANALEKLG-IDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVN---RALDVNHE---------------
>UniRef50_A6DIP7(33-537:554) 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DIP7_9BACT  E=2e-27 s/c=0.25 id=28% cov=88%
-----------LRDGNQALPDPLTLEQKKIYFDILVKIGFKEIEIGFPSASKDDYDFCRHLIdnKVIPDDVMISVLVPARPDLVVKTmDALRDVPKATVHFYVATSDLHREHVLGKSHQEVFEMCTATVQsikeeasKLKESTFYLEFSPEEFTDTDLDFAVEVCDHVIEQWqpaadeKVILNLPATVERRPPTHYADMIE-LFQRKLKSEQAIISLHAHNDMGCAVASTQLAIQAGAHRVEGTLFGQGERSGNVDLITLVLNLQY----LGIDTGLDFSDLMNITEQISELTNMPPHERHPYVGSLVFSAFSGSHQDAIHKStlrkdelmetfgrwKIPYLHIDPADVGRefeNLIRIN--SQSGKGGIAHII------EKEHNIK--LPRFVQV-DFAKRVQAYAEEVSREVSTQEvwkvfEEayiaPKNPKLvlnNYWPYpDEDQSEIVNAKIEVEFKGETFTHEATGNGPISAFVAALKKldIPDFVLEHFGEDSIGDSAQAEAVSSISVKNSDNGSVHIGFGYHSNI---------------------------------------
>UniRef50_C8WRC1(38-551:564) 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=C8WRC1_ALIAD   E=3e-27 s/c=0.24 id=27% cov=92%
-----------LRDGNQALIVPMNLEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTlIERDLVPSDVTiqVLTQSRDHIIERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIVNIAVTGAEQIRDLARTTpgnfffQYSPESFTGTELDFALEICNAVLDVWKPTpdrkviINLPATVELSMPHVYASQIEYMGKRLARRDAIVLSVHPHNDRGTGVAAAELAMLAGAERLEGTLFGNGERTGNVDI--VTLALNLYSH--GIDPGLDFSNLPAIQARVEALTKMQVSRRHPYAGELVFTAFSGSHQDAIAKGMKWREEKSPEHWTVPYLPIDpkdigreyegdiirINSQSGKGGIGYVLEQShGFDLPPKMREQLGYAVKRVSDREQKELSADEIAEIFMREFVNLGQPLDLVELTGTDARGSHRVRATVVWQGETVEIEGA-GNGRLDALCHALEEglgIRVANLTYKEHALEV-GSGSRAVAYIS-VDDEEGNTHFGCGVDTDIMEASAKALVSAVNRM------------------------
>UniRef50_B8FYI5(38-550:557) Pyruvate carboxyltransferase n=5 Tax=Bacteria RepID=B8FYI5_DESHD   E=3e-26 s/c=0.24 id=27% cov=89%
-----------LRDGNQALVVPMSLEEKLEYYHMLLKIGFKEIEVGFPAASETEYAFLRTLIEQnliPEDVTIQVLTQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSREEIVEIAVSGARLLKKYAAETegnfqfEYSPESFTGTEMEFALEICNQVLDVFEPTpenkviINLPATVSLSMPHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQRIEGTLFGNGERTGNVDI--VTLALNLFSH--GVDPGLNFASMLEITAKYEALTRMKVHDRQPYGGKLVFAAFSGSHQDAItkgIKWREEHEchywnvpylLIDPQDIGReyegDVIRIN--SQSGKGGIAYML------EQHYALD--------LPAKMREAFGYKVKNVSDNLHKELMPEEikdiFFKEYVNIENPikflnfhflNHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQaRLgLSYSNLIYKEHALELGSKSQAVSYVGVTGP-DGVIHWGCGIHTDIFTSSVKALISAINTM------------------------
>UniRef50_B3PEP5(150-667:673) 2-isopropylmalate synthase n=90 Tax=Bacteria RepID=B3PEP5_CELJU   E=2e-25 s/c=0.23 id=27% cov=92%
-----IWMSTDLRDGNQALIDPMSVQTKLRMFKELVAIGFKEIEIGFPSASEIDYNFTRMLIEEnliPDDVTIEVLVQARYDLIEKTVQSLRGARRAILHMYNPLAPAFRKIVYNTDKEGVKKIALQGTQWCKELTAQapevdwtFQYSPEVFSSTEIEFVKEVCDAVVEIWNPSpqkkiiLNLPATVEMNTPNTYADQIEWIHRNIHRRDSIVISVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDL--VTLALNLYSQ--GVHPGLDFSDIDKVRKLHEECTQLPVHPRHPYAGELVFTAFSGSHQDAIKKGfavQKKDTLWEVPYLPIDPADLNrsydavvrVNAQSGKGGVSFLLQQEAGLQLPRRLQIEFSSVVqKVSDSTGK--EVKASDIARIFNEEyfavNSPITYQSSKFTEQDDTHqvDIVIHAQHQNKTVEI---SGSGNGPIDAAAHAISQFIDTEVNVIDYHEHSVGEGSDvvAVTYVEIKVK-NGKPVYGVGQDRNIITSAVKALINGVN--------------------------
>UniRef50_A1KBD3(35-554:572) 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=LEU1_AZOSB   E=4e-25 s/c=0.23 id=29% cov=91%
ITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRELiegGHIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFrriVFDTDRAGVKQIaVDSARYFVEMaARQPGTDFTFqySPEVFSGTELDFAVEVANAVIEVWQPTpqqkciINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDL--VTLALNLYSQ--GVHPGLDFSRINEVARTVEHCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGfavqqpdavwEVPYLPVDPADLGRSyESIIRVNSQSGKGGIAYLL------EAEYGLvmprrlqVEFSAAIQRITDERGTELSagdiwraFEEEYLA-VAAPYAYVEHHLAEHGGQQGISLTVEEAGVR-------RVLRGVGNGPIDAALHALDA----GAVLLGYEERAIGQGGDarAVAYIELADGEGGGSTFGVGIHANIVTASVLAIVSALDRL------------------------
>UniRef50_Q7VH30(37-557:558) 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_HELHP   E=1e-24 s/c=0.22 id=27% cov=91%
-----------LRDGNQALITPMSLEEKITFFKLLLKVGFKEIEVGFPAASETEYRFLRTLIEEdliPDDVSVQVLTQAREHIIKKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDEIkhiaCEGAICLKESAAATKGNfrFEYSPESFSGTEVDYALEVCNAVIDIFEPTlekkliINLPVTVEMSLPHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAELGLLAGADRIEGTLFGNGERTGNVDI--ITLAMNMHSH--GVDPKLDFSNIPSICDVYEKVTKMQVYERQPYSGKLVFAAFSGSHQDAIAKgmayHKEHnlstwsvpYLPIDPKDVGrvYESDVIRINSQSGKGGIAYilhhhygvNLPPLFREEFSYYVKNISDKAHKelSPDEICEIFQNDFVNLNNTLCVQD----FHFTHIDSKP-SQEFNVKLHILYAKENSKTQqeiTGKGNGRLDSIANALREHLNLDFEIIDYSEHSlkKGSTSQAVSYVQIES--KGKKCFGVGIDNDIITASIYGLVSALNRI------------------------
>UniRef50_A8L551(44-559:565) 2-isopropylmalate synthase n=38 Tax=Bacteria RepID=LEU1_FRASN   E=6e-24 s/c=0.22 id=28% cov=91%
-----------LRDGNQALIDPMTPSRKMQLFELLVAMGYKEIEVGFPAASQTDFDFVRQLIEDdliPDDVTIQVLTQAREELIERTVTSLVGSDRALIHLYNSTSTLQRRVVFGLDRAGVTDIAVQGARWCAQYAEKLlegtdvrwQYSPESFTGTELDYALEVCEAVMDVWAPTpdnpvvLNLPATVEMSTPNVYADQIEWMSRNLTRRDAVVLSLHPHNDRGCAVAAAELGVMAGADRVEGCLFGNGERTGNVCLVTLGMNLFSQ----GIDPMIDLSDIDGVRRTVEYCNQLPVHPRHPYGGDLVYTAFSGSHQDAIKKGFEamertgqtlwevPYLPIDPKDVGRSyEAVIRVNSQSGKGGVAYLM------KSEYALDlprRLQIEFSGVVQKhtddaggevtAGQLWEIFTREYRPEGGDPAASLELLGSRTTAASGARDEVTVSVRLDGTETVI--TGSGNGPIDAFVAALSE-RGVPVRVLDYNEHALGSGADARAAAYLEVAVGETVLWGVGIDPNIVTASLRAVVSAVN--------------------------
>UniRef50_B2AHM5(36-544:569) 2-isopropylmalate synthase n=69 Tax=cellular organisms RepID=LEU1_CUPTR  E=4e-23 s/c=0.22 id=27% cov=91%
---------TDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRMLIEERRipdDVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGTRLIKALTDAMpetawtyEYSPETFSLAELdfsLEVSDAVSAAWQAGpgrPMILNLPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDL--VTLALNLYTQ--GVAPELDFSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQqqpdaiwevpYLPIDPADLGRSyDAVIRVNSQSGKGGMAYLLEQVHglYLPRRLQIE-FSRAVQAMTDDTG--LEASADDLYGLFRREYLARETPLRYVSHQLASD--ATGATAITVQMERDGQPctvrGTGNGPIDAFIDALDlpvRVMDYH----EHAMTAGADARAAC-YVEVRVGDSPTGF-GAGIDASLVTASLRAVVSGVN--------------------------
>UniRef50_D1N7Y9(25-489:567) Pyruvate carboxyltransferase n=2 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7Y9_9BACT  E=3e-21 s/c=0.23 id=28% cov=81%
-----VWASVDLRDGNQALPEPMGPEHKLEYFNMLVGIGFKEIEVAFPSASADDFNFVRMLIERnliPDDVRISVLTQARRHLIDRTIESLRGVKHAIAHCYVPTSDLHGRFVFNHNREEVKQMAVdgtRMVKEAIEREGlwgkvAYEFSPEEFTDS---DLDFVVEVCCAVkevwGPSTpdmliLNLPATVERRPPNQYADMIELFCRKFPYLNEVGLSLHAHNDQGCAVAATELALLAGATRVEGTVFGHGERTGNLDVSVLALNMESR----GVRTGLNFSNMPEIVRIVERNSGIEVHPRHPYAGDLVFTAFSGSHQDAIRKGfehraeiseffRQGWKIpylhLDPADLGRQYEKLiRINSQSGKGGVVYVLEkEFGVYPPKTMHPEIGAVVQKVVDAEgGEINSADLKRIFYDNFVNAEGP-YRMENYQRASVGDRSGSNFSWFINGEKHEL-SGQGNGPLSAVVHAL---------------------------------------------------------------------------------------
>UniRef50_B7GT76(79-632:638) 2-isopropylmalate synthase n=19 Tax=Bifidobacterium RepID=B7GT76_BIFLI  E=7e-21 s/c=0.19 id=31% cov=90%
-----------LRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRMlIERELipDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLATDAAELCKDLENEAkgidlyyEYSPESFTGTEPEYAVEVCNAVIGVIKPTpehpmiINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCLLGNGERTGNVdlvtlGLNWLTQGIDPQLDLSNV------PEIRKTVEYCNQI---KISERHPYAGNFVFTAFSGSHQDAIKKGLEarqvaaeragadldsfvwlvPYLPIDPKDIGRTyEAIIRVNSQSGKGGMAYLL------KTNHNLDlpkRLQIEFDKIVQNyadttKKEVKDGDIWRLfkdeylpveqsgmtaagVVVGDTHDaslEPWgRLKLLKVAVSSGEDGSDTVlkarlldrGVNVGDDEPVEREASGiGNGPIAAF---LNAISNFGVEasIMDYVEHTMSVGTDAMAasyvECQIGEADDAQIVWGVGIDSSITTSALKAIISAIN--------------------------
>UniRef50_Q1QBL0(58-523:594) 2-isopropylmalate synthase n=5 Tax=Bacteria RepID=Q1QBL0_PSYCK   E=2e-19 s/c=0.21 id=25% cov=83%
-----------LRDGNQALIDPMTIEQKMRFFETLIDVGFKEIEIGFPSAAQVEFDFARKLIEEnhvPDDVTLQVLVQAREHLIARTFESLKGAKRAIVHVYNSTCRIQrekVYAKDKAEIKEIaVTGAKLLVEYAAKYPETewvFQYSPESFSQTETEYAVEVCDAVCdvwrpeNGQEVILNLPATVEASMPNVFADQVEYFCRNLAKREHVTISLHTHNDRGCAVAAAELGVLAGADRIEGTLLGNGERTGNMDI--MVMAMNLFSQ--GIDPELDFSNMSEIVQVVSECNNLPLHPRHPYVGELVFTAFSGSHQDAIKKcldynekhveKTENvwdvaYLPIDPAHIGRSyQDVVRINSQSGKGGVAYILQRnYGFNLPRWMQIDFSGVVQKQAETTARELQNDEILQTFEDTYLQQGSFELLDYTVNNKGGEVYFNGQVQMN-GDTITID-GDGNGPLSSFIDGLAQHTGKSIHVINY--------------------------------------------------------------------------
>UniRef50_Q5KCL7(34-627:639) 2-isopropylmalate synthase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KCL7_CRYNE  E=1e-16 s/c=0.15 id=28% cov=92%
-----IWLSTDLRDGNQSLANPMTNQQKLRFFRHLVQLGFKEIEVAYPAASETDYNFVRELIDRKEVPDDVWIQVLTPARADLIKRTFEAVAGLKhviVHMYNATSCLFREVVFNNDRDETIKLAmdhtILIRQLAEKYAEShgtsfrYEYSPETFSQteTPYAvEVCEAVKKAWLGGHGSVwadgrkeeriifNLPATVEVATPNCFADQVEIFCNSISEREKCIISLHTHNDRGCAVAAAELGVLAGADRIEGTVLGNGERTGNVDL--VTLALNCYSQ--GISPNLDFSDMFSVIDTVTECTGLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEaqakrdhagdqvwsmPYLPIDPADVGCTyEAVIRVNSQSGKGGIAYivksalsldlprRMQIAFYKvvqecseatGREMTSKDITTAFRQTYHLGGSIYDGRLVLKSFV----------TVDLFSSQTpsvaGTPDLSpirsrsqTRMPPLSLSSSVAEPSPDrsldrnlpsmskrltakvlvdgklheivgeGNGPLSSFLNALESDLGIVLSVREYTEHAVGAGSDvkAATYVELIpANVDAKDktqggFWGVGVDADITASGLKAVVSAAN--------------------------
>UniRef50_D1XS06(74-605:612) 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. ACTE RepID=D1XS06_9ACTO  E=7e-16 s/c=0.17 id=28% cov=92%
LTRAPLWVPVDLRDGNQALAEPMDAARKRRMFDLLVAMGFKEIEVGYPSASETDFGFVRHLAESgaVPDDVTVSVFTAARSDlIDRTIASVEGLPRTLVHLYTATAPVWrdvVLGRSRAELHAMItDAATHLLRRAgeRPGADiRFEFSPEVFNLTePdfvleVCDsLTELWEASPDR-PVVHNLPATVEIATPNVYADQIEYMHRHLARRDSVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDL--VTLALNLFAQ--GVDPMVDFSDIDAVREVVEHCNRLPVHPRHPYGGELVHTAFSGTHQDAIAKGMARhakraaeqgvpaaeapwevpYLPVDPGDIGRTYEEvIRINSQSGKGGVAHLLRaHHGLDLPQAMRPDFSRTVQRVTDGTGR----ELTA-------GELGELFRTTYLaaagqgsveAVSWSTAETAPGVHTFTCvlrvdGREHSCR-GTGNGPLAALTDAL-RTAGVTVGVLGYWEHATTAGPDSPAAAYAECRVDGVTAWGAGWDTSVLTASVHSVLSAVN--------------------------
>UniRef50_Q7UI51(15-515:527) 2-isopropylmalate synthase n=1 Tax=Rhodopirellula baltica RepID=LEU1_RHOBA  E=0 s/c=1.38 id=48% cov=96%
-TRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGFPIASPGDFESVRQIATTIRGATICGLARCAEKDIDRAWEALKTAPQARIHVFLATSAIHREFKLRMTPDEIVERAVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTINVPDTVGYTTPGEIYDRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIECTINGIGERAGNAALEELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAIVGRNAFAHESGIHQDGMLKERTTYEIMSPEEVGFTKTDLVLGKHSGRAALADRAKQLGMTLTGEQLQEVFEAFKELADKKKEIYDGDIVALVQQKISETVAPEWTLVDYEVTSGKNQTPNVRVTLRRDEQdITEQVAQGDGPIDAAFWAVEKITGIQVVCKDFRVRSATLGRDAIGEVNLEVEHEGKTYRGTGVSTDSVESTILAMLNAINRIVA----------------------
>UniRef50_Q2YBW0(1-509:510) 2-isopropylmalate synthase n=2 Tax=Bacteria RepID=LEU1_NITMU   E=0 s/c=1.32 id=50% cov=97%
MKDHLIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGFPAASNGDFEAVKAVAAAIKGSTICGLARAIEGDIRRAGEALRGANSARIHTFIATSPIHMEKKLRMSPDQVVEQAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTVGYTMPQQFGELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGLGERAGNASLEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLAELGIELeSEETLNATFMRFKELADKKHDIFDEDLHALVSD-DAAALQEHYKLLSLTAHSETGETPHASIVIGEEGRESRAESDGSGPVDATFRAIEKILNSGVELQLYSVNAITSGTDSQGEVTVRLQKSGRIVNGNGADTDIVVASAKAYLSALNKLHSKLERAHPQ--------------
>UniRef50_A7Z7B8(2-499:518) 2-isopropylmalate synthase n=11 Tax=Bacillales RepID=LEU1_BACA2   E=0 s/c=1.34 id=46% cov=95%
--RKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRGDFLAVQEIARTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKLKMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDTVGYLTPDEYGNIFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAINGIGERAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLNTLGFQFDSDEINKYFTMFKELTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHYGTSQVPTATVSLKNQENEQLmqEAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKGEDALAQVFVRVTVNGKESSGRGIAQDVLEASAKAYLNAVNR-------------------------
>UniRef50_A6EER4(5-500:502) 2-isopropylmalate synthase n=3 Tax=Sphingobacteriales RepID=A6EER4_9SPHI  E=0 s/c=1.31 id=47% cov=95%
-PNRVYVFDTTLRDGEQVPGCQLSTPEKIEIAKALEALGVDVIEAGFPISSPGDFQSVVEMSKAVQEPIICALTRANKGDIDSAVAALQYAKRPRIHTGIGSSDMHIKYKFNSTREKILERAVDAVKYAKQFVEDIEFYAEDAGRADNVFLAQMVEAVIAAGATVVNIPDTNGYCLPDQYGSKILYLKENVKNIDQAIISVHCHNDLGLATANTLAGIVNGARQIECTINGIGERAGNTALEEVVMILKTH-HALGLNTNINAKHFSDISNMVSRMMRMPVQPNKAIIGQNAFAHSSGIHQDGFLKHRENYEIMNPEDVGINSADIILTARSGRHALKHHLERLGYEIERLNLDQVYERFLILADEKKAISDDDIHSLMSDGKEDSYKNGYKLTLLQVLCGDPLSPTASIKLEHNGVEKEAMASGNGPVNATINAIQSIVGADIELKEFTIQAVNGGSDDVSKVNIRIASEGKSYVGHGFSTDIVKASAYAYLDAMNK-------------------------
>UniRef50_A3DF94(2-496:511) 2-isopropylmalate synthase n=3 Tax=Clostridium thermocellum RepID=A3DF94_CLOTH  E=0 s/c=1.31 id=44% cov=94%
--RRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPGDFEAVQRIAREVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDTVGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVFTHESGIHQDGVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERLNKLFNDFKKLTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIKDsKGNLLEAEQTGNGPVDAVFKAINSVIKetENLTLYKYSVSAVTEEMESLGEVSVTLREKEKLYTGIGTHTDIITSSAIAYID-----------------------------
>UniRef50_A6LDN1(1-498:500) 2-isopropylmalate synthase n=6 Tax=Bacteria RepID=A6LDN1_PARD8   E=0 s/c=1.28 id=50% cov=95%
MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGDFKSVVEISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYKFNSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDTTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTINGIGERAGNTSLEEVAMVFKSHKE-RDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRNAFAHSSGIHQDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDLEQEKLDKVYDEFLKLADRKKDINDDDV--LMLVGKDRTATHRIKLEYLQVTSGVGVQSVASICLNLSGVRRYEAAAGNGPVDAGIKAVKKaISNSDMTIQEFLIQAINKGSDDTGKVHMQVEYNGATYYGFSANTDIIAASVEAFVDAINK-------------------------
>UniRef50_C0Z635(1-507:514) Probable 2-isopropylmalate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0Z635_BREBN  E=1e-176 s/c=1.22 id=43% cov=96%
MTKRIHIFDTTLRDGEQAPGASLSPEQKIVIAKHLADLGVDVIEPGFPISSPGDFMAVQRISQEVHGVEICGFARAVKEDIDAAVRATQAAERRRLHMFLSSSSIHLDFQLRKSREQVIKIAREMIAYGKQFVDRFEFSPMDATRTGDEFLFEMIEAAIEEGATIINIPDTVGYALPEEYGAMFTRVMKNVRGSDKVEFSAHCHNDLGLAVANSLAAIRAGVTQVEVTVNGVGERAGNCSLEELVMAIETRKEALDAETRIRPEHIYTTSQKVSRAMSFPIAFNKPIVGRNAFQHEAGIHQDGLLKERSTYEIMDPESLGVPRNMIILGKHSGRHAIKHRVNEFGIQLTDEQMEALYVQFKELADKQKVVQDHQLLELVGH-TVNAVLEPFTLVNAQVLTGTSGHRMASCTImnNVTGEEQAYSGTGEGPVEALVAGIKQALPFDVEFTDMELYSLSSGEHATGEAIVTVSANGSHFKGVAEHRDVLMAVAQAFMAASNQAVR----------------------
>UniRef50_A2C859(7-518:540) 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_PROM3   E=1e-175 s/c=1.21 id=49% cov=95%
---RVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFSAVQRIAQQVggdEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPSEFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGNAALEELVMALYVRRRYFNPFfgresdsptplTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSE-QVQQPEARFQLRLVQVSCGSSLRPTATVILAQeDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTIRLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVA----------------------
>UniRef50_A9KRN2(2-502:505) 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=A9KRN2_CLOPH   E=1e-172 s/c=1.21 id=42% cov=95%
--RKIYVFDTTLRDGEQVPGAKLNFEEKMYIAKQLEKLRVDYMEAGFPSSSQGDFEAVREISRQIKDSSVVALGRAVKSDIDRMYESLKEAANPMIHIVLGSSNVHITKKFNKNPEDILQMGVDAVTYAKRYTSQVEYSLEDASRSDLEYMWRTIEAVVKAGATCVNIPDTVGFAVPELFGGLIHQIYDRLQNVaPHVLLSVHCHNDSGLATANTLAAVRNGANKVECTINGIGERAGNTSLEEVVMGIKLHPEYYDGYTDINHSAIYETSRIVSRTMGLDVQVNKALVGENAFAHSSGIHQDGLLKSKEVYEIFEPSDIGAPPMDIVLTARSGKHAFEYISKKLGYEIAPEVLNEIHANFLKIADEKKEVYDNDVIDLLDgdeRVQKNGEKKLWMLEDFQINV-NMNLPSATVKLVRNKQEAVVSEAGNGAISALYAAILKAVDMPIHLIDYRIQNIGAEKESLGKVVVQIQYNGKFYFGKAIERDVMKASALALVNSVNKIV-----------------------
>UniRef50_A8TGZ1(52-574:574) Isopropylmalate/citramalate/homocitrate synthase n=1 Tax=Methanococcus voltae A3 RepID=A8TGZ1_METVO  E=1e-159 s/c=1.08 id=36% cov=94%
------IFDTTLRDGEQTPEVSFPIKAKLEIASKLDELGVNTIEAGFPITSNGEFEAVKKIKQLDLNATICGLSRCSNKDIDAVID----CDLDRIHLFIATSPLHREYKLKKSKEQILNKISESIIYAKEHGLSVEFSAEDATRTELDYLIRVYKEAITSKVDYIDIPDTVGILTPKKMENLIKDLKSGLetnkainnsstltnqinikSNMQMPVLSVHCHNDFGLAVANSLSAFEQGVSQIHCTVNGIGERAGNTDLAEFVSSLKFLCGIEPETLTIKTELLSDISKLVAHYTNIPIAPNKPLVGRNAFAHESGIHTHGVIANALTYEPISPFDVG-NKRRLVLGKHAGAHSIKLKLQEMGLnvgkNLSTEQFEEIVDKIKALGDKGKLVLDADLRAIIkdVTSKVIKSKRVVNLEQLAVITGINVIPTASVAVNIAGKRYKASEMGVGPVDASLKALESVVGetVKAKLIEYTINAATGGSDAIADVVVKLENNKKIVTAKSTSEDVVHASVEAVIEGINRLL-----------------------
>UniRef50_P74269(8-543:547) Uncharacterized AIPM/Hcit synthase family transferase sll1564 n=103 Tax=cellular organisms RepID=LY41_SYNY3  E=1e-145 s/c=0.97 id=27% cov=96%
------LYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQLQEEPlEQAEIVAFCSTRRPhkavETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLAENLAMISDTIAYLRSQGRRVIYDAEhwfDGYRANPDYALATLATAQQAGAEWLVMCDTNGGTLPGQISEITTKVRRSLgldgQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMVQGTINGYGERCGNANLCTLIPNLQLKLDYDCIEPE-KLAHLTSTSRLISEIVNLAPDDHAPFVGRSAFAHKGGIHVSAVQRNPFTYEHIAPNLVG-NERRIVVSEQAGLSNVLSKAELFGIALDRQNpACRTILATLKDLEQQGYQFEAAEASFELLMRQAmgDRQPLFLVQGFQVHCDLLTPAEnpayrnalATVKVTVNGQNILEVAEGNGPVSALDQALRKALTRfypqiaDFHLTDYKVRILdgGAGTSAKTRVLVESSNGDRRWTTVGVSGNILEASYQAVVEGIEyglRLLTCGLTNQE---------------
>UniRef50_D2RHQ3(2-529:529) Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHQ3_ARCPR  E=1e-143 s/c=0.97 id=34% cov=93%
----LRILDTTLRDGEQTPGVSLTVEQKLIIAQALDDLGVDVIEAGTAIAGEEEFRAVKEIANAGLKAEICSFARIKEIDID----AVANADADSVFMVAPSSDIHIKTKFpNKSGDDIIEMSVKAVEYAKERGLIVEFGAEDSSRANLNFVKALFRAVLDAGADRLTFTDTVGVLTPEKAECIMRELTSEF----NVPIAFHGHNDFGLATANTIFAVKGGAREIHVTINGLGERAGNAPLEEVVLALET---FYGIKTKIRKEKIYDTSKLVEALTRFPIALNKPIVGYNAFMHESGIHTSALLRNAKAYEPISPEMIGRKRA-IVHGKHSGKASIMRLIEELGYEASGEQVKEIMKRIKEMEGRGQKVMGSDLIKIIEEVLKVKKGKKIVLKGLNVVCGkSGTSPHASIKICLNGEDIEATALGKGPFDASIRALKNALKeyanksgdkavgelVNVKLVNYKANAiiddkvieyieklveknpklsglvekirIMTGTDAPVDVIIQLEKDDRVVTAIGRSTDIIHASVEAYIECLNKLI-----------------------
>UniRef50_C3NF24(31-535:553) 2-isopropylmalate synthase/homocitrate synthase family protein n=19 Tax=Thermoprotei RepID=C3NF24_SULIN  E=1e-139 s/c=0.98 id=29% cov=93%
--KSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVEYIEGGWPGSNPKDEEFFKEIKKyKLSKARIAAFGSTKRKDVsvkeDISLNSIIKADVDFAVIFGKSWSLHATEVLKVTKQDNLDIIYDSINYLRSHGLKVIFDAEHFYqgfKEDPKYALEVVKTAESAGADVIALADTNGGTPPFEVYEITKKVREVL----HVKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGERTGNADLIQIIPTLVLKMGFNVLKGRDSLRKLREVSRIVYEILGLPPNPYQPYVGDNAFAHKAGVHVDAVMKVPRAYEHVDPLLVG-NDRKFVISELSGTANLVSYLQGIGIVVDkkDERLKKALNKIKEL-ETKGYSFDVgpASAILITLKELNMYTNYINLEYWKVINENNGLSIGIVKV----NSQLEVAEGVGPVNAIDRALRMALQRvypeisEVKLIDYRVILPSEvkNTESVVRVTIEFTDNKMNWRTEGVSKSVVEASVMALVDGLD--------------------------
>UniRef50_B2UP78(1-537:544) 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8  E=1e-137 s/c=0.91 id=28% cov=95%
MSTKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFNAMrGVGLRNAKLAAFGSTHHpshtPETDPTLTALISSGARVAAVFGKSCPRHVEVALGISRERNLEIIGNSISFLKknmeEAFFDAEHFFDGFKR-DQEYALAVLRTAWEHGADCLVLCDTNGGTMPEEISSIIRTVRERLP---HALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNGIGERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNAAFAHKGGVHVSAIMKEAALYEHIDPSLVG-NAQRVLMTEQGGRSNILSLSRTLGFELEKGDplLDVLSAAVKKNAALG---YDYvAAPASAELLFLRHMPDNALKPYFNIlrtvvltsrhEMDPDMMVEASLKLDVHGNVEHTAAGGFGPVHALDRALRRALTRwypeleQMHLIDYKVRVLSptrtnipeaedeNGTGSNVRVLIESSDGVATWTTVGVSYNIIEASLEALADAVTyKLYKTEQ-------------------
>UniRef50_A4QAP0(63-609:616) 2-isopropylmalate synthase n=225 Tax=cellular organisms RepID=LEU1_CORGB  E=1e-136 s/c=0.89 id=27% cov=94%
---------VDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKdmiPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATDAAELIKTIAQDYpdtnwrwQYSPESFTGTEVEYAKEVVDAVVEVMDPTpenpmiINLPSTVEMITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGERTGNVCL--VTLALNMLTQ--GVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYAGDLVFTAFSGSHQDAVNKGLDamaakvkpganstdvsweelrdtewevPYLPIDPKDVGRDyEAVIRVNSQSGKGGVAYIMKtDHGLQIPRSMQVEFSAVVQNVTDaEGGEVNSKAMWDIFATeyLERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVD-GHGNGPLAAYANALEKL-GIDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVNR---ALDVNHE---------------
>UniRef50_B3TC58(9-521:530) Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ  E=1e-132 s/c=0.92 id=26% cov=93%
----IEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPKDLEFFKLIKKhELRNSKIAVFGSTRRKNITAKNDNnlkvMVDSEALVSVIVGKTSSFHVEKILNCSLEDNLEMIydslIFLRESGLQTYFDAEHFFDGYNINP-EYAIQTVKTAEEAKVNTIVLCDTNGGMLPH----QIERVVKKIKKNSEVKIGFHGHNDTGCAVANTVSAVVAGATHIQGTINGLGERTGNADLCQVIPNLemKLKKKTRNIQKKqiINFGKLRDISNYINELVNINSFDHQPYFGKFAFSHKAGLHVDGMLKSSKAYEHINPEIF-KSERSFTISELSGKANIIALSKKFNfqIDKDDKRIIDILEEIKKL-EFSGFTLDNADATtyLIFLRHLGLYKQYFHVDSWKVLTEkqNQINSKSEIKILIGENIYTNNAYGVGPVNSLAIALRKSLQnkypeiNKIELTNYKVSIVGASKDTasLVRVFIEFKKDEVVWATTATSQNILDASLRALIDG----------------------------
>UniRef50_D2QST1(1-505:506) Pyruvate carboxyltransferase n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QST1_9SPHI  E=1e-131 s/c=0.93 id=28% cov=94%
MKRRyIEIMDTTLRDGEQTSGVSFSASEKLALAQLLLtEVKVDRVEIASARVSAGELEAVQQITRWADSigliDKVEVLT---FVDGQASLDWLQASGAKVMNLLTKGSLNHLTHQLKKTPGEHFTDIGQVVCAAGKLGVKANVYLEDWSngmRNSPDYVFQYLDFLNTQPILRVLLPDTLGVLTPAESYSFVHQLVTRYPNLH---FDFHAHNDYDLSIANVMEAIRAGAHGIHLTVNGLGERAGNAPLASAIAVL--RDFMPEVRTGVVEKSLYQVSKIVETFSGLRIPDNKPVVGDNVFTQTAGIHADGDKKNNLYFNALLPERFGR-KRSYALGKMSGKANIENNLRELGIQLSEDDLKKVTQRVIELGDQKEVVTREDLPYvISDVLNTNSFASRVEVLNYVLTHSKDLKPSATLRVRIDEEHFEESAQGDGQYDAFMNALKKIYVKKkltlPLLTDYAVRIPTGGrTDALCETIITWKHKNGEFKTRGLDSDQTVSAIKATQKMLNTL------------------------
>UniRef50_O86511(13-520:534) Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO  E=1e-130 s/c=0.92 id=28% cov=92%
------VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEIdfKHAQLVAFGSTRRAGANAAedhqVKALLDSGAQVITLVAKSHDRHVELALRTTLDENLAMVADTVSHlkaqGRRVFVDCEHFF-DGYRANPEYAKSVVRTASEAGADVVVLCDTNGGMLPAQIQAVVATVLADT----GARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANLFPVVAALELKYGK-QVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVG-NTMRMLVSDMAGRASIELKGKELGIDLggDRELVGRVVERVK---ERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITedrpdgshaNEATVKLWAKGERIVATAEGNGPVNALDRSLRVALEKiypelaKLDLVDYKVRILEGvhGTQSTTRVLISTSDGTGEWATVGVAENVIAASWQALEDA----------------------------
>UniRef50_A6DIP7(22-553:554) 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DIP7_9BACT  E=1e-125 s/c=0.85 id=24% cov=93%
---------VDLRDGNQALPDPLTLEQKKIYFDILVKIGFKEIEIGFPSASKDDYDFCRHLIDNkviPDDVMISVLVPARPDLVVKTMDALRDVPKATVHFYVATSDLHREHVLGKSHQEVFEMCTATVQsikeeasKLKESTFYLEFSPEEFTDTDLDFAVEVCDHVIEQWQPaadekvILNLPATVERRPPTHYADMIELFQRKLK-SEQAIISLHAHNDMGCAVASTQLAIQAGAHRVEGTLFGQGERSGNVDLITLVLNL----QYLGIDTGLDFSDLMNITEQISELTNMPPHERHPYVGSLVFSAFSGSHQDAIHKStlrkdelmetfgrwKIPYLHIDPADVGREfENLIRINSQSGKGGIAHIIEkEHNIKLPRFVQVDFAKRVQAYAEEvSREVSTQEVWKVFEEAYIAPKNPKLVLNNYwpYPDEDQSEIVNAKIEVEFKGETFTHEATGNGPISAFVAALKKLDIPDFVLEHFGEDSIGDSaqAEAVSSISVKNSDNGSVHIGFGYHSNINHAAARAIIAAVNKLI-----------------------
>UniRef50_UPI000038E0F9(28-375:388) 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0F9  E=1e-117 s/c=1.22 id=38% cov=67%
--ENISIFDTTLRDGEQTPGVSFNTDQKYKIAKMLYDAGVNIIEAGFPAVSNDEMKSIKKINHDMEN--ICSLARCNRNDIDKVIES----DSRIIHLFIATSDIHMKYKLKKTREQVFDSIMESIDYARSYGMRIIFSPEDATRTSMDFLKQI---VSSIKVETINFPDTIGIMNPISMY----YFINKIKSFTSTGISIHCHNDFGMATANTLAGLMAGANEAQVTVNGIGERAGNASLEEVVSSIY---GFLNSYTDIKMEKLYSISKYVSAASGIIPQKNKAITGENAFSHEAGIHVQGIINNPKTYEAINPEIFGLNR-RIVIGKHSGKAAIKYILENNGMHKTDDEIDNILQIVKKEGNK-------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0W2B6(3-538:551) Alpha-isopropylmalate/homocitrate synthase family transferase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W2B6_9ACTO  E=1e-113 s/c=0.76 id=28% cov=94%
LTPRVATYDTTLRDGAQQQSVSFTVEDKLAVARILDHLGVTYIEAGWPGAIPKDTEFFARAASElsLATARLVAFGSTCHPGTaaekDPQLRGLLDSGAPVITIVAKSDPAHVERALRTSGEENLRMVADsvglLVAAGREVMVDLEHYVDGVAR-DPRYGIELALTAARAGASAVIPCDTNGGSLPGTVAAEISRLRAALdaAGHEDCVVGIHTHDDSGLAVAAAMAAVEAGARQVQGCVNGFGERTGNANLLTLIANLELKTGYQALagdsqERARRLAELSAVSRTVGEIANRAPSGRLPYVGSKAFAHKAGLHASAIKVDPNLYQHVDPARVG-NTMTMLVSEMAGRASIELKARELGIETgGDKELLARVTEVVKGREAAGYAYDAADGSFELLLRQAlgQLPQYFRVESWRASvtarpaAGQEILPedgatvtdsEATVRMWVGGRRLAVLGEGNGPVNALDHALCDALAtaypeiRAFELTDFKVRILDSerGTHAIVRVLIDITDGERSWSTVGVGTDIIEASWEALTDG----------------------------
>UniRef50_D2RXB9(59-438:438) Pyruvate carboxyltransferase n=3 Tax=Halobacteriaceae RepID=D2RXB9_9EURY  E=1e-112 s/c=1.07 id=40% cov=70%
-----RVFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDAEFEAVRDIASST-STTTCGLARVVDADIEAALDS----GVEMVHTFVSTSDVQIEDSMHATRDEVVERAVESVERVTETGTTCMFSPMDATRTDEQFLLEIIEAVSEAGVDWINIPDTCGVATPTRFRAMIEKVCAHT----DARIDVHTHDDFGLATANALAGIEAGADQAQVSVNSIGERAGNAAYEEFVMAVE---SLYQTDTGIDTTRITELSNVVEEKSGMATPGNKPVVGDNAFSHESGIHAAGVIENSDTFEPgvMTPEMVGA-ERRLILGKHTGTHSVRERLAELGFEPTDDQVRAVTRRVKDFGAEKRRVTVDDLERFAEE----------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A2QSZ0(29-559:566) Contig An09c0020, complete genome n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QSZ0_ASPNC  E=1e-108 s/c=0.75 id=25% cov=80%
-----RWLSTDLRDGNQALVQPMNGDLKLRYFQTLIKLGYKEIEVSYPSASQTEFDFTRYLISTpgivPDDTWIQVMAPCRDELIQRTIEAVRGARKVVLHIHLSTSDLFREIVYLMTKKEMIDLAVRCMRMIRELTKDsldaemrktewtMEFTLENFQDTSVEFALEICEAVKAAWEPTtenkiiFNLPSTVEISMPNVFADQIELFCRGISEREKVCVSVHPHNDRGCGVAAAEMAQLAGADRVEGCLFGNGERTGNVDLVTLALNLYTQ----GISPRVNLGNLNEVVAMVEDCTKIPIHPRAPYAGKYVFCTFTGTHQDAIRKGynqlqesekhdatqtpkwRMPYLPMDPADLGRqHEAIVRVNSQSGKSGVAWLLEEsFHIHMPRELEIEFTKIVKTYANMSGfEITQETIRRLFREHYMHADSEKARLLDCRAdeTKGDRVVTQVQLKVAVEGSEHDLEATG--------------------------------------------------------------------------------------------------
>UniRef50_C4XS62(10-371:394) Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XS62_DESMR  E=1e-106 s/c=1.07 id=39% cov=69%
----LIISDTTLRDGAQMPGVHFSINDKVAIAQALEAAGVDVIEAGFPAGGAGEIEAVRQVAAATARPLIMALCRAVDADVDAAWQALGDAPAERrgVGVFLATSPLHRRHKLGKTKAQCLAMIASSVAYARQRFARVTFGCEDGSRTEPAFLREAYTAAMDAGATAIGFPDTVGVLTPETARRRIAMLV-RLAQPRGVKVRAHFHNDLGLATANTLAAIAAGADIVHLTVGGIGERAGNAALEETVMALTLHPGQYRRAINVDTTRLTALCRLVAQRAGFTLPPNKAVTGANVFATAAGVHQDGLLKHPDTYLPFRPELVGAEGIRLPLSPLSGKAALALRYTELGIALSADELSRA-SRLVKDADK-------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1FHL1(63-631:662) 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO  E=1e-105 s/c=0.68 id=26% cov=93%
----VVCYDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTSSGLadraaagGTKLAAFGMTRRRgvtaDDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLGVSPEENIamieESVAHLVAAGKEVLVDCEHYF-DGRKANPEFAVKCAAAAAKSGAKFVVLCDTNGGTLPWDVEEFTREVKEAVdATGADCSVGIHCHNDTSLAVANSIAAVRGGATMVQGCVNGYGERTGNADLLVVAANLELKMGRTAL-PEGSLQRLTQVSAAVAKLCSQHQDPRQPYMGSSAFAHKGGLHVAALQKMPASYNHIVPTLVG-NEARSVISELSGRGNILSAAMASGREVSKETAAQVLSQIKDL-ESRGFVLE-DAGASVDILFRRADPNYrapFNVLEFNVTASNSSFGGFTPNdLLVGGDERLQdvlpedeleapfthpqqagykkgsvavnqvvvkvdvfdndttpasrntqlcVAEGNGPVNALANALRlSLTDkfpqlKQIHLQDYKVDLLsTAGTSAAV-TRVTMDFADRdtdiTWRTVGAHASIIEASFRALVDGM---------------------------
>UniRef50_D2L197(17-385:400) Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L197_9DELT  E=1e-102 s/c=1.01 id=40% cov=67%
----LILSDTTLRDGAQMPGVRFSVDDKVAIAKALADAGVGVIEAGFPAGSEREIEAVRRICAEVPGPRIMVLCRAVAGDIDAAWEALADAapEGRGVGIFLATSPLHRRHKLGKSKAQCLDMIGRAVAYARKRFLKVTFSCEDGSRTEPAFLRQAYGVAMDAGATGIGFPDTLGVLTPEAVRRRVR-MLAALAHPRGVRLRVHFHNDLGLATANTLAAVAAGADIVHLTVGGIGERAGNAALEETVMALILNQKQYRRSIGVDPAKLTGLCRLVSRLSGVPLAANKAVVGANIFATSAGVHQDGLLKHPDTYLPFRPEAVGADGIRLPLSPLSGKAALALRLAELGIELSPDEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2FKU8(5-375:393) 2-isopropylmalate synthase n=3 Tax=Methanomicrobiales RepID=Q2FKU8_METHJ  E=1e-101 s/c=1.00 id=35% cov=68%
---HIEICDVTLRDGEQTPGVSFTADEKKDIASRLDAIGIEVIEAGFPIVSAHEKEMVRNISRLGLSAKICGLSRACREDVDAALD----AEVDMIGLFIAPSDLHLKYKHKKPRDVVVANALEQLDYAVDHGLIVRFGAEDASRTDPDILVDIYRQAADHKATYVTYADTTGCLTPLEVATVMKDLVPKTP----IPIAMHAHNDLGCATANTLIAAELGAYQLHTTVNGLGERAGNARLEEVLVSLVLK----GGITRYDLTEIPALSERVQQYTGIFMPATKPVVGANAFAHESGIHIAAILENPETYEFIPPELLGL-ERRFILGKHTGKRALVHILTSFGYHITDEQVMQVLELIKDKSEDKCSI---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9K7B8(61-569:582) Similar to 2-isopropylmalate synthase n=1 Tax=Alternaria alternata RepID=C9K7B8_ALTAL  E=3e-92 s/c=0.67 id=26% cov=89%
-----VLFSTDLRDGNQSLPNPMTFEQKLSLYKLLVSIGFKEIEVAYPCANQAEFDFVRHLIETpgliPEDVLIQVITPCQEETIKRAVESVRGAKQAILFTYLPSSDNYRDTVLKISEDDWVERARWGAAYARSITKDSEdpvvrstrwtfnFGFEDFANARIGAIIRCTEAVRAEWNPskdekmIIGVASSVEASTPNVFADQIECLSGNISNRDTVRLTVHTHNDRGGAVASAELASLAGADRIEGCLFGNGERAGNMDL--VVYALNLLTQ--GIEPGIDLSRLDEIRKVYEDITELPVHPRTPYSGAYYLKAFSGAHQDAISKGlrlrtsatqegkpcavwpawRVPYLPLDPADIGRSLDDVVgINSQSGKGGVAWVVNlGLGLDLPPGLARTFSKAVKERSIHFGREMSSDEVCMAF------------LEEYQVLRAADKSDDDMIQAVLRTESPLVAALGqvVG-LSSLSASITSHTLAD-DVLSY-----------AAYANVTPEESKPSLWGVGLGVSLQQAKLRAVVSAL---------------------------
>UniRef50_Q44290(3-371:377) Homocitrate synthase 1 n=45 Tax=Bacteria RepID=NIFV1_ANASP   E=2e-91 s/c=0.92 id=35% cov=68%
---KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISNLGLKANLLAWNRAVISDIKASV----ACGMERVHIAIPVSGIQIAAKFHGQWRVSLQRLKDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYGKVKLLVSALT----IPVEVHTHNDFGMATANALAGIKAGASSVNTTVIGLGERAGNAALEEVVMAIK---RIYGVDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFAHESGIHAHGVLQNPDTYEPFAPEEVGW-ERRLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAVRQQSIKKKR----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8WE03(7-382:402) Homocitrate synthase n=3 Tax=Zymomonas mobilis RepID=C8WE03_ZYMMN   E=9e-88 s/c=0.87 id=37% cov=70%
--KHLIINDTTLRDGEQAPGVAFTLSEKLHIAKALDEAGVDEIEAGIPAMGASEIEAIRQIVQQSQTARVIPWCRMKISDVDKALET----GAKTVHLSISSSPFQMAAKFpDLSAADILGLCQKVISYAKDRGLDVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFADTLGILDPFATYEIISQLHQ----ISPLDIEFHGHDDLGLATANSLAAIKAGAKGASVTVLGLGERAGNAPLEQVVIA---ASHIAGKETRILPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQHESGIHVAGLLRNPASYEALNPEKLGR-QREIVLGKHSGRAAIRHALSLLGIKAQEDMIQNLLAAVKMQASHQKRAIGLSEIALI------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000038E0D5(1-352:377) 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0D5  E=5e-83 s/c=0.88 id=32% cov=67%
MPLKVGILDSTLREGEQTPGVLFNKNQRIEIAQLLSDAHVAMIEAGHPLVSPDIYSAIKEImdmkASGMINSEIIAHSRAVNSDIDSAA----SLGVDRIAIFYGVSDIHLDNKTHRSRTEALDIIYDSISYASSTGIPVRFTAEDASRTDINFLRNVVRTAVDAGADRVSIADTLGILTPEKTA----YIFNNLSDIKGVEYDFHGHNDMGMALANGLAAAESGATIIHSTVNGLGERVGIIPTQALGVLLNYH---LGVD-AINLLSLKPLSELIEKYSGITMPPNYPVTGSTAFTHKSGVHVDGIIRNPGTYEFMDPSRLGL-QHSFTIDKYSGKHALREKLANMGINADDNKISYMLEKIK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1J0N9(680-955:974) Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI  E=2e-72 s/c=1.00 id=38% cov=49%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVMALKCRgeKALGGLYTGINIRHIVKTSKMVAEYSGLQVQPHKAIVGANAFAHESGIHQDGMLKHKETYEIISPEDIGLfrsNESGIVLGKLSGRHALKSRLLELGYEIEGMELDDIFWRFKEVAEKKKNLTDVDVIALVSDEIFQ-PKVFWKLGDLQVTCGTLGLSTATVKLiDADGQKHVACSVGTGPVDSAYKAIDLLVKEQVTLLEYGLNAVTEGIDAIATTRVLIRGEKnhtltnaltgetvhRSFSGTGAGMDIVVSSVRAYISALNKML-----------------------
>UniRef50_B6YRB4(5-348:374) Homocitrate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRB4_AZOPC  E=2e-76 s/c=0.84 id=29% cov=66%
-----FLIDSTLRDGEQAPNVVFLRKEKIRLAQMLSEIGIDEIEVGIPAMGEDECNTIQNIVRLKLRPIISVWSRAIKKDIEQA----STLGATCIHIAFPLSDIQLQ-AINKTYGWVEDTFSKTIQCAKNLFERVSVGAQDASRCPIDRVIQFIDMAEKYGVFRVRFADTVGILTPIQTIEIIRTIKKKKTNMN---IDFHAHNDFGMATANALTAYQVGANSLSVTINGLGERAGNAALEEILMGLR----QINGKTKYDLSTLFDLCRYVSVISGRPLPDGKAICGKFAVSHESGIHTQAILSDILAFQPFNGDILGREKCSILFGKHSGKRAIIDLLKRQNIEVEESRISLLIEKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8F3U8(34-414:415) 2-isopropylmalate synthase n=1 Tax=Thermotoga lettingae TMO RepID=A8F3U8_THELT  E=3e-75 s/c=0.75 id=33% cov=71%
LPEQVIIHDVTLRDGEQMAGVVFTEDEKVFIAQELDKIGVPMIEVGFPAVSGEDQRVFKRLSKMNLKAKKIALARIMDEDVKLAAE----CGADG--LFYETSinPYFVKYVLGLDSKEFIDRIIKGAKLAKELGLFVEFcGWDTFRINNLEWIKTVYTELLKnVEVDQIGISDTFGQAHPFTVNFLVRKMKEWFP---SIPLSIHVHNDYGLATATALMAIASGAEAVETSFNCLGERTGNASTEEVIAGIEM---ILGIKTNVDCQELYRVSKMIQEVSKMHVAPNKPIVGDRIFDSESGIVIDANEKINRATEikyamyPYNPENFGR-WLKYVGGKKSGRAFVKQYLDKRGLKANEAQIDEILVRIKKIGTvLKSALSDEDIDRIVELVL--------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q10Y65(2-336:462) 2-isopropylmalate synthase n=1 Tax=Trichodesmium erythraeum IMS101 RepID=Q10Y65_TRIEI  E=3e-67 s/c=0.77 id=32% cov=58%
----VQIVDSTLREGRQtAPGINFSWEQSLKIAKLLHSLGIDIIEVCHPVVSIEQKQIVREIVASNLCPVIAH-ARANLADI----EAVKETSAQWVGIFLGINEETRLTRARWTISKIFNCIKESVMYAKTLGLKVRYTAEDASRTDYCLLKSVYSVAIEAGADCICFSDTVGIMEPNEVTETIEKLKSDF---STVPLEVHFHNDRGLAMANALAASDAGAERISSSVNGLGERCGITD----TLGLLVNLYYKGLRSLPSGEIIQRTSKYVAAFSRYPVNFNQPISGGNAFIHTAHLHQKAVKRDPSSYSWILPEYVG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001B425AC(1-241:258) 2-isopropylmalate synthase n=1 Tax=Listeria monocytogenes FSL J1-208 RepID=UPI0001B425AC  E=5e-64 s/c=1.03 id=38% cov=46%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFLTRMEEIGYTLSEKELKDAFKRFKQLADAKKEVTEDDLHALI-LGQSSESADDFELKHLQVQYVTGGVQGAIVRIeERNGALIEDAATGSGSIEAIYNTINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKDnNGTEFHGIGIDFDVLTASAKAYLQA----------------------------
>UniRef50_Q0W3Q1(16-402:468) 2-isopropylmalate synthase n=8 Tax=Archaea RepID=Q0W3Q1_UNCMA   E=4e-63 s/c=0.63 id=31% cov=64%
-SAEIKISDTTIRDGCQMPGVVMKKSHKLQIFEYLHEMGVEKLET-FVY-NDRDKDACKSMMDYGyEFPEVTGWARANPADID---EVLKVDGIRETGILMSVSDSHIFDKMGlKSYAEAEQKYLKALQYAIDHGLKTRCHIEDTSRANYEFVYPFVQKLIEIDPDTIIrICDTLGYGIPFPGYEEpygIPTVVKNLKEMGVKHIEMHVHDDFGLGIGNTLAGLWYGADWASLTFLGIGERAGNTELEKIMAFLITRVEGFEKY---NLQKATEFAEYMEQEIGLRVPRNKAIVGKNIFSHESGIHTAGIIKNPFTYEPFPPELVGGKRN-LMIGDTSGTDVIRLKVEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0PEC7(30-399:403) Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PEC7_9FIRM  E=5e-63 s/c=0.66 id=26% cov=70%
----IKIHDVTLRDGEQQAGLVLTCDQKIALAEKMAELGIHRIEAGMPAVSAEDARAVSEIVKRRLPTEIFGFARCMVDDVKRAAD----CGVSGIVIEIPSNEEMIREAYGWSLEKAVELSVKATKAAQGAGLYTVFFPIDMTRANIDWVLKLIgQVAADGHMDALAVVDTMGGLAPHT----VPYLIDAIKSRIDKPLEVHFHDDFGLGVANSIMGLAAGADVVHTTISACGERAGNAAYEHLALALLT---MYGYDLGLDYSKIYSLSKLLRSFIDLPVRGNMGVIGDRVFDIESGI-VAGWYKNVKNTNPLlvtpyLPELTGHPGTEVVLGKHSGGPSIDCWADRLHIKLDKEQKSDLLGQIKLAACKKGNTLDEQEVRLLF-----------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1L5J0(22-413:426) 2-isopropylmalate synthase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5J0_KORCO  E=5e-56 s/c=0.56 id=29% cov=63%
----LLITDTTLRDGQQG-SRPFSKEECIKIYSILSELdggsGVIRdIEL-FPYTS-KDREVIKALRDFGTTPNPIGWIRARIED----LKLVKECGLDTTVLLTSVSDYHIHYKLRMSRTEAREKFLSAIREGLRMGLKLKVAMEDITRSDIYgfvlpFIEDILRISErEGGEVSFKISDTLGLALPFPesplprgVPRLIRSLIEEM-GLRSEQIEFHGHNDFHLVVANHLAAWLYGASISNCTLMGIGERAGNCPLE----AMAIMHSQLSGERKLNLKALSKIIDVFSE-MGFRIPEFYPILGENAFKTKAGIHIDGLLKNPAIYLPFDPTIIGRPY-SIEISPYSGRSGIIYWLaRKLNIEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0GSN3(27-388:399) Pyruvate carboxyltransferase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GSN3_9DELT  E=6e-56 s/c=0.61 id=27% cov=68%
--KKVFMLiDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETGSVGRDE-ELETLIKYARQHHGSTKISLWSPCR------IQELEYADSldpDIISAALPVSDLHIEKRLGLDRCGALRLLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVWRVRLSDTLGVMEPGELMEAVRPFREKL----DISLAFHGHNDFGMATANALTALSCGVDYVDVSLLGIGERAGIARLEEVLTFLVYNKGHAGY----DVQSLPELSTCVAGLAGVHINPDRAVLGRQLFHCESGLHADALYKSFDLFEPFEPHKMGM-QRRISLGRKSGAGAVRGKLMEMGVNPDFVDLEGLVRDVRRAASIKGSPLDDE-----------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6T1C1(1-187:210) 2-isopropylmalate synthase (Fragment) n=1 Tax=Xenorhabdus nematophila RepID=Q6T1C1_XENNE  E=6e-55 s/c=1.17 id=70% cov=36%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRSGRAAVKHRMTEMGYQENDYDLDILYQAFLKLADKKGQVFDYDLEALVFINQQQQEYEHYRLDYFSIQSGTNVVPTATVRLACGDEITSEAATGNGTVDAIYQAIGRITGYPLKLISYQLSGKGHGKDALGQVDIIVECFGRRFHGMGLETDIIESSARAMIHVLNNIWQAEQVEKEKQRISHCN-------
>UniRef50_Q05FR2(11-419:447) 2-isopropylmalate synthase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FR2_CARRP  E=1e-54 s/c=0.53 id=25% cov=62%
--KKPIWVSEDLRDGNQSLINGYNLKNKINIWEFLIEVGFKQIVLGFPSSNKHDFNFINYLKKNrliPNNVFVSVLTPAKTNSINLTIDSLKGIENSIIHLYNSISKIQRKLVFKMNKNEIKNFTInfflYTISKIKKKNIIFQYSPESFSDCELIYSKKICyifsyLCYINNVKSIINLPITVENILSNKFVNSVLYIKKK---KFNSLLSVHTHNDMGGAITSSILSLLSGIDRIEGTLLGNGERSGNSA----IMILASNYYNLGIDPGINIfnNKIFYFLKK-NNKSRIPWYSNLNYV------AFSGSHQDAINKSyfkkkkfnwNIIYVPINPKIFnFKHKNMIKINIQSGKGGLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q97A78(4-342:344) 2-isopropylmalate/homocitrate synthetase n=1 Tax=Thermoplasma volcanium RepID=Q97A78_THEVO  E=2e-49 s/c=0.59 id=25% cov=63%
--------DDTLREGMQAPGIAFTLDEKIRIAQSISKSGIKRALVSYPSAHESEVEAARKITDLHLFDDTYSLGRSIKEDVD----SIISTGSKV--------TLHLPF-----GDYDINKICDVVKYASDHSDSVEIAIVDMVKYEKEKIFDLAKKLWECGASIVQIPDTTGRATPKRVHDVVSYIKQNL----KVKVEVHCHNDHGLAIANSIAGIEAGCDYVDTTIFGIGERNGIAD----TASIASYLEKAGYEDKINFEMLRKTydlmSELILRKAGYRfFADNMPIFGRNVLSITAGTH--------------STSKVFPN-SRVSLNVYAGSRLVASILRKNGIEPDERKVKLLVSKIKDLSSNEGRVVGEDE----------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7YY11(122-397:398) Putative uncharacterized protein n=2 Tax=Nectriaceae RepID=C7YY11_NECH7  E=3e-44 s/c=0.66 id=31% cov=44%
------IIDTTLREGEQFATAHFDTETKIKIAQALDEFGVEYLELTSPAASEQSKLDCQAICKLGLKAKILCHIRCNMDDARIAVQT----GVDGINMCIGTSAQLMKHSHGKDLDWIAKKATEVIQFAQSHGVEVRFSGEDSFRSDFSEIIKLYSLVDRLGAQRVGIADTVGGATWREVDEKISTLRQVI----SCDIETHFHNDTGCAVSNAFTALEAGATHIDTTVLGIGERNGITSL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8J227(49-494:611) Pyruvate carboxyltransferase n=2 Tax=Desulfovibrio RepID=B8J227_DESDA  E=5e-42 s/c=0.39 id=25% cov=74%
-AEQMRITDTTFRDGQQARP-PYTVKQVAKMFDFLHRLGGKTglITAsEFFLYSAKDRKCIDVCrARGYRFPRVTAWIRATRDDLKLA----RDMEFDETGMLTSVSDYHIFLKLGKTRQQAMDMYVGMAEQALEWGIIPRCHFEDITRADIYGFClplaqRLMELSRQSGMPVkIRLCDTMGYGVPYPGAALprsVQRIVRAFTDEAGVPgqwLEWHGHNDFHKVLVNGVTAWLNGCGAVNSTLFGFGERTGNTPLEAL---LVEYISLTGDDAAADTTVLHEVAQFFEKELDYRIPHNYPFVGRDFNATSAGVHADGLAKNEEIYNIFDTKHLLGRSVPIIITDKTGRAGVAYWIntnlnleKERQISKKHPAVGKIYDAIMAVYEETGRTTNFSHVEMEALV-QRFMPELFVSEF--------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7GH85(86-408:443) 2-isopropylmalate synthase n=3 Tax=Roseburia RepID=C7GH85_9FIRM   E=8e-41 s/c=0.53 id=28% cov=58%
MPENIWITDTTFRDGQQSR-APYTTEQIVTIYDYLHRLGgpkglIRQSE--FFLYSKKDRDAVyKCLERGYKFPEVTSWIRASKQD----FQLVKDIGLRETGILVSCSDYHIFYKMKMTRREVMNLYLSVIRECLETGISPRCHLEDITRSDIYgfvipFCVELMKLMDEYKIPIkIRACDTMGYGVnfpgaviPRSVPGIIYGLTTH-AGVPSELIEWHGHNDFYKAVNNSTTAWLYGASGVNCSLFGIGERTGNTPLEAMVFE---YAQLKGTLDGMDTTVITELAEYFEKELGYVQPSRTPFVGSNFNVTRAGIHADGLLKNEEIYNIFD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2LTE1(61-488:634) Isopropylmalate/homocitrate/citramalate synthases n=43 Tax=Bacteria RepID=Q2LTE1_SYNAS  E=3e-40 s/c=0.39 id=23% cov=63%
-AEEIFITDTTFRDGQQARP-PYTTQQIVDLYQMMSRLgGYNGIirQTEFFLYSNRDKEAVRMCQDLGLQyPEITGWIRAAREDIPL----VKEAGLKETGILTSVSDYHIFLKLNMTRSQALEEYLGIVKAILDAGIVPRCHFEDITRADIYgfcipFAIELMKLREESGVDIkIRLCDTMGYgvtypgaSLPRGVDKLVRAFIDD-ADVPGRLLEWHGHNDFHKALINATTAWLYGCSAANSTLLGLGERTGNPPIEGLIIE---YIGLMGKTNGIDTTVITDIANYFKNEIEYKIPSNYPFVGADFNVTRAGVHADGLIKSEEIYNIFNTTKILKRPIVPMITDKSGKAGIAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6DPR1(3-174:189) 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DPR1_9BACT  E=3e-40 s/c=0.98 id=27% cov=31%
----VKIFDTTLRDGQQGKGISFTVEDKIKIAKLLDENGVSYIEGGWPGASPKVEAFFKEIKNvELKNAKMVAFGSTRRasnsAEDDVFLNKIVQSGAPVACIFGKSWDLHVHEALKISLEENLDVIESSIAFLKksglEVFFDAEHFFDGYKRNP-EYAIKCLQAAEAGGAEVLV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1WUS8(3-322:359) 2-isopropylmalate synthase n=2 Tax=Streptomyces RepID=D1WUS8_9ACTO   E=2e-36 s/c=0.49 id=34% cov=55%
-------------------GVEFSPADAAAIADLLVRTGVELVEVGmvsGPDS--KDAELVLATHEAVTPERSMTLVVVR--DRRQVARALDEAERLGVrHIMysIPTSEEHAQLKLdSASPKFLQALARSAIQQAKERGFHVTFSGEDGARTPRERLVPYVAAGFAAGADRFRLAETVAYLSPWQMEEVIADLTA----IDGSEIEIHSHNMLGLAVANSLAAVRAGARWISATVGGIGERGGNAPLAELLTSLRVLHG----DTRFDLTHLTELSRIALRGAGLgdafqsgPTTPH-------AFAYE----LPGQLSHPQAYETLPAELVG-NSRELRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000038E183(4-344:345) 2-isopropylmalate synthase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E183  E=5e-35 s/c=0.44 id=26% cov=41%
--------DDTLREGMQTPGFAMSYDEKIELAKLISSAGIKRALVAYPPAHKSEFEVTAAIVDGKYFQQVFGLGRTVKEDIDMINET------------GANISLHLPFKL-----DNMGQVYENIKYACTLGKIVEIGFVDIDMFSVEQITKFCHKMEELNVDVVQLPDTRGKMNP----AAIKNVFEAAKKATNIKIEAHCHNDYGMAVANTISAISAGVDYIDTTIFGTGERNGIAD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4VB43(62-453:474) 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. Mg1 RepID=B4VB43_9ACTO  E=1e-34 s/c=0.38 id=25% cov=63%
------------RDGAQAKTL-MTAGFRVRLARETGRIfGSDgprhvVIAAGFPAVCGEEFEAVRRVAGEAEGAVsVAAVCRGARRDLEQAVASVRGSRQARVMVVVPASEAMARVMVHRAAREALQAGVDLVKRARDLDEGVAVDvcLADASRADHALMAHYARAMTGAGAGLVVLADTVGAQLPSGCAEMFRRVRAE--AGSEVVLASHLHNDLGLGLANTLEALAAGVRVASSSWLGIAERAGMVATEQLLFLLArharelLGAGAAPWWSPPDLTRLPVIAEMVAGETGVPLGVTTPIVGTGVGSLSTGtpfVH-------PRLFQPYDPqELLGITP-RVVLTHLASARVVAAVATRLGHTLDGER---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2GT72(28-327:340) Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GT72_CHAGB  E=3e-32 s/c=0.47 id=24% cov=57%
----------------QPVGDYLSNVNKFKIiestLRALDEFGVDYIELTSPAASEQSRKDCEAICKLGLKAKILTHVRCDMRDAKIAVET----GVDGLDVVIGTSSFLREHSHGKDMAYIEKTAIEVIEYIKSKGLEVRLSPMPSARS------------------------------------------------------------------------RTGATHIDTSVLGIGERNGITPLGGLLARMVVSAPDY-VKGKYKLHMLKEIEDMVAEAVEVNTPFNNPITGFCAFTHKAGIHAKAILNNPSTYEILNPADFGLTRYVHFASRLTGWNAVKTRVGQLGLVMTDDQVKEVTAKIKAMADvRPIAIDDADSIIRSFHLTLHERP---------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8G187(2-268:333) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfitobacterium hafniense DCB-2 RepID=HOA_DESHD  E=2e-27 s/c=0.47 id=29% cov=45%
--KKVKIFDLTLRDGSHAKSHQFTPEQMAVLAEQIDSTGVAAIEFghgnglggsalqyGFAAATDREYmEAVAPVVKNADLSIIILPGVGTRHELHLAKE--FGAKYARMCT-------QITEV---------DIAEQHIKMAKQLGMIPIAVLPCAGIIPVKDTVRYTQMAESYGAEVIYLLDGGGYQLPEQTYERIAAMKKAV----DVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCCLKGFGAGAGNCPTEIFAAVM----DRMEIDCGID---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7IGE0(5-175:179) NifV2 n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGE0_9CLOT   E=3e-24 s/c=0.67 id=27% cov=24%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFAALEELVMILRIAKRH---KPNMDLSVFREIKELYQELTGCHIAGNKAVIGDHIFDVESGIHVDGILKKSSNYEPFEPKVVGMSRN-IVIGKHSGKSAVELKLKEYGVIPKNEKISLLLTRIRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9A1R9(1-351:352) Pyruvate carboxyltransferase n=2 Tax=Archaea RepID=A9A1R9_NITMS   E=8e-24 s/c=0.32 id=27% cov=44%
MSKKVQILDTTLRDGSYSVNFSFTSSDTSIICSKLEKSGIKLIEVG---------------HGLGFNASNSGYGKSTQSDEEymiAAKESLSKSMYGMFCIpgIAKLSDLELAKKHGMGFIRVGTDVTkvhqseKFIKKAKNLGF---FVASNFMKSyvmPPDKFASIVKQSEEFGTDMVYIVDSAGGMF---SSDLLEY-YNSIRNVSEIPLGFHGHDNLGMAISNSLYAADLGMEYIDSSLQGIGRSSGNACTEVLVMALK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4XM98(43-327:331) Pyruvate carboxyltransferase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XM98_CALS8  E=5e-23 s/c=0.39 id=24% cov=51%
IPSKLYVTDSTFREGQQA----ISYIGKENVAKIFEYL--HYVDNGTGTIKYSEFflytnyhkQCVQEcLKKRFKFPKVVGWVRSKKDELKLA----KEFGLDEVGILMSCSDYHIYKKFQKTRSEIAARYIDIIQEAFSLGITPRVHLEDITRSDIEnFVIPLILAIEEMAKKCdkkvyFKLCDTLGFGVPYEYASLPRSVPKLIYTISKSTdvpperLEWHGHNDFYKAQSNAVCAWLYGASMVNCSIRGIGERTGIAALEVAILDLVQIKDEN--APNLNFEALDELLEFTSRF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9LMV8(7-285:314) Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LMV8_HALLT  E=7e-23 s/c=0.40 id=25% cov=49%
--------DVTLvemlpRDGFQRLDEFVPTDEKVEIIDALSETGVDEIEITSfthPKAVPTlrDADEVAQRIERHDDVTYRALV-PNAVGMERAID----AGVDKVNALVTVSETYSEHNQNMTVEEILTGVEEIVEMAEGTGIEVEagmgtsFYCPYEGRIPMEDTLSVVDRVVDAGVDEVTLATTMGLADPVEIEEMYTTVFDRHPDLDA---GLHLHDTNGMSLANTLVAMQCGVDRFdasHCGLgggvvlpDGLGG-VGNTPTEDLVQMLT----RMDLETNADFERVESVAHEVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4IT42(5-271:342) 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteria RepID=HOA_GEOTN   E=1e-22 s/c=0.41 id=23% cov=49%
--RDIWITEVALRDGSHAINHQYTVEQVVSVAQALDEANVPYIEVshgdGLAGSSlqyglsrTDEMELIEAAVSVCKKAKIAVL---LLPGIGTIRELDAAAKRGVKMVRIAT---HVTEA---------DISAQHITRAKELGLEAVGFLMMSHMASTEKLVEQAKLMESYGADVVYVVDSAGALLPHEVTERIRALKQSL----GIEIGFHGHNNLSLAMANTLAAIQEGATRIDGSVRCLGAGAGNTQTEVLVAVL----DRIGLKTGVDLYKMMDLAeEIVAPILQVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001B44BFA(8-250:483) 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Mycobacterium tuberculosis KZN 4207 RepID=UPI0001B44BFA  E=3e-22 s/c=0.45 id=29% cov=44%
-----IVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGaaaaqgpaahTDEEYFRAARSVVRNARlgaVIVPALARIETVDLAGDYL---DFLRIC-VIATE---------------FELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEALR----GASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQ-RRDLAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2S7Y3(19-293:311) Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=D2S7Y3_9ACTO  E=4e-22 s/c=0.40 id=26% cov=50%
-----------MRDGLQ-LEAPVPLEGKLAMLEALVATGVRRIEVTS-FVSPK---AVpALADADQLAAELSSFqGVHFSALVANARGATRAVDAGVAHLeyVVSASDGHSRANAGRSTAEAVAAVGEIAALAHGAGGSLEVVVATAwdcpfdGRTPIPRTVDVARAVVTAGADRLCLGDTIGTTTPMRVVQLLDAVRRACPG---VEVGVHFHDTRGTGQANALAAVQAGVTQLDSSVGGLGgcpfapGASGNIATEELVYML----EESGVRTGIDLDAVLAAARVTEQAVGRPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0Z8X0(14-306:312) Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE  E=5e-22 s/c=0.37 id=24% cov=48%
--------SVTLtevspRDGFQNIEQWIPTETKINIVEGIFRSGVKNIEV-------TSFVSPKAIPQMKDAAIVAEYAVAMAKNTDVNIMALIPnvkgaeralsCGIRKVNYIISASPLHNKKNMNRTPQESFEALCELKKNFPEadvtLGVATAFGCPFQGKVPVDDVITLMRAARDIGINSFTLCDTIGVANPRQVETLLHEVKKNFSDIQ---LALHLHNTHGMALANIYAAMLQGVDRFESAIGGLGgcpfapGAAGNAATEDLVNMLN----RMEINSNIDLAKLLDVANQI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000050F830(4-293:311) pyruvate carboxyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050F830  E=1e-21 s/c=0.37 id=26% cov=52%
LPERARVVEVGLRDGLQAIDTPLSTDRKIAIVSEMIAAGFKEIEVASfahPKVLPqlADAEAVLAGIPRPPDVRFRALVPNARGALRAA-----KCELDELTFVVPAEDgMALKNQGTTTdglldqLDEIREVSGGAGQRLIVAVACAFFSP-CYGPVSKDARDKVVRKAIEVGADGVYLATTTGEETPLELFSGISETKHDFPDLE---VGAHLHNRNGFAPANALAALSAGADWLESSVAGLGgdmwfpgdpSVLGNMATEDLIHLL----DGMGISTGIDLNRVRHISEGLIEETKFPVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8WQC0(1-297:301) Pyruvate carboxyltransferase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WQC0_ALIAD  E=4e-21 s/c=0.35 id=27% cov=43%
MGERVWLREVGPRDGLQNEPGVIATEIKVELVERLMDAGVRFIEVSSfvhpkwiPQLADADEVFAR--IRRRPGVELSALVPNERGLARA-----LAAKVDAVHVFMSASESHNLKNINKTIADtypvlrpVIEGAKAEGLVVRGYVSTV-FGCPYEGKVPVSQVLSVVERLFELGVDEVALGDTIGVAVPTQVAEVVREVERIVP-LDRV--SLHFHDTRGMAIANMYAGFAAGVRRFDGSIGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6BTH8(3-263:337) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta proteobacterium KB13 RepID=B6BTH8_9PROT  E=1e-20 s/c=0.40 id=29% cov=46%
-SKKILISDPTLRDGSHAIKHKFSKDDISNYCKLADKARIPIVEVGhgnGIGASSlqlgesllSDFDMLSTARKNLKKSKlgvhvIPGFA-TIDKDILPAVD--VGVDVFRIATHCTESDLSERHIsfLRKKNLEVWGclMMAHMV--------------------DTETLIDQAKKIENYGADGVIFMDSAGSFIPNQIKERVEGLVSEL----NIMVGFHGHNNLNLAVANSLEAIQSGATLVDACSAGFGAGAGNTQLEVLIPVLL----KQNFDTNIDFNGLLDLAEFV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6LV01(109-295:304) Isopropylmalate/homocitrate/citramalate synthase-like protein n=2 Tax=Clostridium beijerinckii RepID=A6LV01_CLOB8  E=4e-20 s/c=0.55 id=25% cov=29%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATAMSLEWVKAGGKKVVTTFAGIG---GFAPLQEI---LGGSSFLEKIKDHSNYKLFPKVLSIFEDITESKIRGNAPFIGKDIFNVESGIHVNGIAKDSRTFEPYDPSEIGRKRN-IIIGKHSSVNALEIKLEELNIKYEHDNLTIMLEDVRKLSTQKR-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7NPM1(258-504:707) Pyruvate carboxyltransferase n=2 Tax=Roseiflexus RepID=A7NPM1_ROSCS   E=6e-20 s/c=0.41 id=32% cov=44%
------------RDGT-LQGFHLTVDEAWEAVRGMDSLGVGVIElPSFPANPPGQafnRRLLERAAAHGLTTTFAAHARCVAADIRTAAET----GFRRLHLYIGVSPIKQATA-HANAVQLADKAFDAIHLARDLGFDcVRISTEDAYRTPLDDYCAFYERLQErltshgLHVDGIGIPDTVGVGTIDDLGDRIAVLRQV--GIRFVFLECHIHNDIGhsdrLYVDTLLLCMRLGIMMLpDFSILGIGERNGTIGLSSLIEAIY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5KC29(3-260:830) AMP-binding enzyme domain protein n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KC29_9RHOB  E=1e-19 s/c=0.39 id=27% cov=41%
------ILDTTLRDGSYVNNFSFTLDETRFFTRELSRLGLELIEVGhgiglgatekgiSPAV-ETDQDYMKAAAlaveesgsQKAKWGMFCIPGIAELNHIDLAHDHNMGFIRIGVTV------------------EDINLARSFVEKSKKLGLYVCVNFMkSYTSSPQEFSAAVAQAA-SFGADIAYLVDSAGTMVPADVEDYFRTVRRN----SILPLGFHGHNNLGLANINAYTAYNEGAGIVDVSMQGMGRCTGNTSTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8M6W8(1-245:348) 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salinispora arenicola CNS-205 RepID=HOA2_SALAI  E=4e-19 s/c=0.40 id=29% cov=44%
MSVKLQICDSTLRDGNHAVAHQLGRADISAYARAAEEAGVDVLEVGhgnglGASSIQvgiaavSDAEMLRAAKAELRNSRLGVLSIPGFASVERDLKPALDCGVDEVRVGA-----HCTEAD-VTRQQI-TMLRSMGVRVKGLLL----------MSHMASAGKLVEQAglmQEYGAEAVVLMDSAGAYTPEMVREKVGELVEKL----DIAIGFHAHNNLGLSVINSITAVRAGASIVDVTARGFGAGAGNAPIELVAANLHV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1YV80(10-271:328) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YV80_NOCDA  E=5e-19 s/c=0.38 id=25% cov=43%
-PRRPRILDVTLRDGGYLNDWRFTDATVREHTKVLGEVGVPYVEVGYisddPGREPTLRcapDLLRQVGEDAGPARVVAMLAVNGRSPDEVAALLRP-RAEVLDVVRLTCLL-----------ERLDHVLAAAEAVRASGVTCSLNLISVTAYEPGELAGAAERVARAGvADWLYLADSRGALLPEHAAELFAGVRAAWPGLA----GFHGHDNLGHAVANSRIALEAGFDLVDGSLHGYGLGGGNTDLAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1G528(5-299:319) Pyruvate carboxyltransferase n=2 Tax=Proteobacteria RepID=B1G528_9BURK  E=1e-18 s/c=0.33 id=26% cov=50%
--EKVTVREVGLRDGLQMVRTILSTEQKLEWCRRMVEAGSVEIEVTSfvpPKIVPQFADAV-EVARGALD--ITGLhAAALVPNLKGAQRAF-EVGLSKVHYVLSASNEHnLKNVRRTTAESVEDFArivleRDTVERtARRITLGAgvatAFGCTISGRVEESGVLGLVETLLEAGADEITIADTVGYANPRQVKALMREV---LAITRDVPVACHFHDTRGLGLANVVAALDAGVRSFDSSLGGLGgcpfapNATGNINTEDTVFLLESE----GFDTGINIDALLAIRETIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9WGE2(2-301:317) Pyruvate carboxyltransferase n=5 Tax=Chloroflexaceae RepID=A9WGE2_CHLAA  E=3e-18 s/c=0.32 id=26% cov=52%
--EAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGS-FVNPRQVpqmagidQIARMLIERGHN-----LAARTTNDLfrftalvpnQRGYELAAAAGLRHVRLVLAASDgLNRANFKRTTAESLIEFSRFALNIRRDgltfgVAIGAAFGCPFDGYVSPERVRAIAEHAVDIGAGEIILADTTGMAVPTQVAALCRTILDRIPD---VTVTLHLHNTRNTGYANAFAAWQVGIRSFDAALGGIGgcpfaPRAvGNIASEDLV----HLFNGLGVPTGIDLSALIAASDWLSATLGRPLP---ALVGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8FC60(7-321:339) Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FC60_DESAA  E=2e-17 s/c=0.30 id=23% cov=52%
-PKKVTVGDITVRDGFQHEEIFIPTDAKVWVAEQLILAGFKRIETtnyGPPKLMPqfKDADELtrrlrnsKKIKHLIDDVELTAIT-IREKAAERAIQAkLDGNGPDRILFMVSTSESHHKTNSGLSLDAYWKMCEEYIPKAHDAGLKVCGTVSTIWGCPIEGPTELQKAVdftkrwLDIGADDIEHADHDGSAPPNKVYDYFSLILDQIPDPSLHV--AHFHVTRGWGCANVLAALQAGITHYESTIGGLGgqpanfcdrvpvggtgkyyyEDASIVGLIS-TEDMVVMMDEMGIDTGLDVDRLLDIGRMMEKIIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C34E31(19-264:351) hypothetical protein ClM62_09706 n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34E31  E=4e-17 s/c=0.37 id=27% cov=42%
--KKIQLMDCTLRDGANVVGKGFSAEITDMVLDGLTSCKVPIIEfgnaggigayevAGFTNAL-TDSEYL-EIAKKYLNrgSEIGMFLnakRYREKYVDMAAEnglAFLRVGADA----GDGS-----------------IALQAIADIKKRGMKAYYSAMKAYLLTADELAEEGKRLEEAGLDEITIMDSAGTMLPEQVAEYTRKLSEAV----SIPVAFHCHNNLGLSAANAIAAFENGADILDCGLMGMARSAGNLP-TEICAAM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6JJQ3(3-294:303) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA   E=7e-17 s/c=0.31 id=25% cov=50%
LPEKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEI-------TSFVNPKWIPQMVDSKEIC--ETCVKKNerkyevivlcpNKKGIENAISSGAEVISVVISVSEAHNKANVNRTVEESFKELEEMVYKYPNMKFRLDlatvFGCPFGEEIKPERVSELIEKAKKIGVKEIMLADTVGLGNPVLVEKILKQVKEQV-GTENIIL--HIHDTRGMGLANMLVALQLGYSIFETSIGGLGgcpfapGAAGNVATEDFVNMLN----GMGINHNIHLEKLYHTLDLIDQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0FWC0(28-324:337) Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Roseovarius sp. HTCC2601 RepID=Q0FWC0_9RHOB  E=1e-16 s/c=0.31 id=21% cov=50%
LPSKVHIVEEGAREGFQSEPAGIPTSEKIRLIEALAETGVPEIDCAS-FVNPKvvpqmaDVAQIAEGIRKREGVTygcmwlnAKGFLQAAESG--LSLPALTS---------GSASDTFLARNNNATPEKQLEGQRKLRALYTEHGlgrgpvylftaFGCNYEGDIPVAKALERAADLVGVCEEAGQPpsCIYLCDTIGAADPLQVRALVEAVRTRWPDY---PVALHLHDTRGLGIANAMAGLELGVARFDASVGGLggcpfaGNRsaAGNIATEE----LALLCDRMGIETGIDIPALLGVAQIAEEIVNHPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3Q4B9(12-271:363) 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bacteria RepID=HOA1_MYCSJ  E=2e-16 s/c=0.35 id=29% cov=46%
----VRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVthgdglggssfnyGF---SKTpEQELIKLAAETAKEAKIAFLmlpGVGTKEDIKEAQN--NGGSICRIAT-------HCTEA---------DVSIQHFGLARELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAEL--GDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVF----DKIGVKTGIDFFDIADAAEEV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8KZT0(6-254:359) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodococcus jostii RHA1 RepID=Q8KZT0_RHOSR  E=2e-16 s/c=0.36 id=30% cov=42%
LRDDVRIVDTTLRDGSHAQSHQFTESQVRDTVRALDGAGVEVIEVthgdglggstfnyGFSRIS--DLELVQVAADTAEQAKIAVL---LVPGIGTADDLRKAADRGAEVVRIAT---HCTEA---------DVSLQHFEIARDLGMQTCGFLMMAHRTTPEELARQARLMVDAGCQVPYVTDSAGALLMHEAKDRFDALITEV--GDDAWVGYHGHQNMSLGVANSVIAYEAGVRYIDGSLCALGAGSGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0CZY8(11-274:300) Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CZY8_9CLOT  E=2e-16 s/c=0.34 id=23% cov=46%
------------RDGFQNVKEFIPTQEKLQIIDGLVEAGFKKIQITS-FVSPK---AIPQMRDAAELSEV-VLSKYKSLQVFALVPNFYGARLAVetgiqeLTPVISLSESHnmanVKRTVNESVEEIKQI--------RQTFPDIRITQDIAcvfgcpfeGEMQVEALLELVGKLREIGVDAFTLCDTVGVAYPTLIERVFRAVKTQFPG---VEFNAHIHDTRNMGTLNSYVALLSGAYSVQTAVGGLGgcpfapGATGNTSSEDLIYMLN----HCGYDTGINFETLLRTARF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q21QR6(2-288:308) Hydroxymethylglutaryl-CoA lyase n=5 Tax=Proteobacteria RepID=Q21QR6_RHOFD  E=3e-16 s/c=0.31 id=27% cov=48%
--EHIFITDVAPRDGLQSQAVTVSTSNKLRLIRALADAGVRSVEATsfvSPKAVPQMADAAEVIAGLRFLESETGLrTSALVPNIKGLERATAVGAREIAVVISATKTMNLKN-INMNLAEAEENCKATLHAARASGLatrayiavAWECPFEGV--TDPDTVVRLAAAMRVAGAGEIVIADTIGAAAPGQVAALLRVLAQSIPLD---MLAVHFHDTRGMGAANAYAALEAGVRRFDASVGGIGgcpfapGAAGNLATEDLVM----LAHQCGFTTGINL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9F2G5(24-310:328) Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=A9F2G5_SORC5   E=3e-16 s/c=0.31 id=24% cov=51%
-ADEVSIYEVSPRDGLQNESAMIPIEGKRRLIAALVGAGLRRIEITS-FVSPKwvpqlaDAEELARTLPAERGVTFSALCPNARGLERALAVGLRE-----IAVFLSASEAHNRANINKSIDdtlsvfsEIVPPAREAGLAVRAYVSTV-WGCPYEGDVDPARVVRIAERLIDLGCYQVSLGDTIGVGTPRQTHDIVRRFLDAMPPER---FALHLHDTRGTALANILVGLELGVRDFDASVAGVGgcpyapGAAGNMATEDLVFMLH----GMGVRTGVDLDKVIEAGNVAEQVIGRPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5A1I6(3-230:595) Pyruvate carboxylase subunit B (PycB) n=18 Tax=Archaea RepID=C5A1I6_THEGJ  E=4e-16 s/c=0.39 id=25% cov=39%
---KVDIIDTTFRDAHQSLIATrLTTDDMLKIAETMDRIGFYSMEV-WGGATfdvcirylkEDPWERLRLLREHIRKTKLQMLLRGqnvvgykHYPDdvVEKFVELAHKNGIDIFRIFDALNDVRnMEVAIRKAK-EVGAEVQGAIAYTTGKVFTLEYY------------MKKVEELLKLDVDVITIKDMAGLLTPWKIYELVSEIKETY----GIPVNVHTHSTTGMAVAVYLKGVEAGAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1VRH5(2-270:340) 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellular organisms RepID=HOA_STRGG  E=5e-16 s/c=0.33 id=28% cov=48%
--KQVVIHDPTLRDGQHAVHHRLGLTELRRYAEAADAARVPVVEVG-------------HGNGLGASSLQVGLAAATD---DAMLSTVREAlRHSRLGTFMlpgwGTSDdlrraiSHGVDVFRVGVHATeASLAEHHLGFLRDAGAEAHCVLMMSHMASPGELAEQAARAVGYGAQAVGIMDSAGHFLPPDVTARIGAIVEAV---GTVPVIFHGHNNLGMAVANSVAAAEAGARIIDGCARGFGAGAGNTQLEVLVPVL----ERSGFATGIDLYALLDAADLAER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IEM5(5-252:340) Putative uncharacterized protein n=1 Tax=Pseudomonas entomophila L48 RepID=Q1IEM5_PSEE4  E=5e-16 s/c=0.36 id=26% cov=43%
-TQSFVLMDCTFRDGGfQT---DWRFSDAMvgRYFGMCQATGVDIVEMGYlnldPAAGVSHLGSFKALPESLSDVqrQQVDLGpmraavmidawRILDQPAQAAAEvimaAIRRSPFPIAILRIAA----MSSQLAGSLALAKALAGQELAVMINLMQAAELTPEQ--------LAQDLPALAVEPVTALYFADSFGRMLPEQVHRLFSRARELTP----LPLGFHAHDNYGLAVANTQAALDAGARHADGTFAGIGRGAGNAPTETL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3PWS9(4-238:301) Hydroxymethylglutaryl-CoA lyase n=12 Tax=Mycobacterium RepID=A3PWS9_MYCSJ  E=1e-15 s/c=0.37 id=22% cov=44%
LPAKVDIREVSLRDGLQIEqPIPLSA--KLELLEAVVATGVREVEAtAFVSPSKVPALADAAALAAELGRFDQVEFSALVASSNGAKRAI-AAGLRSIEYVVSAADSHSRANVGRSSMESVAAIPDIVAIAHDSGATVEviiataWDCPFDGPTPPQRVVEIVDAAVGFGVDRLAIADTIGTATPRRVSDLVTQVR---PRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDSSVGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7MUV0(18-307:314) Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD  E=1e-15 s/c=0.30 id=26% cov=49%
LPERVTIWEVGPRDGLQNERTTVPVDVKLEFLDRLADAGLTTVEA---------TSFVhpKWVPQLADAEEL--LARLRRRDGvrypvlvpnERGLDRALAAGVTHVAVFASATESFARRNLNSGLDAQFAMFEPVIARAREAGLDVRgYVSMCFGDpwegiVPTEQVVTVGRRLLDAGCTQLSLGDTIGVAT----AAAVERLLDAFIEGGVAIadLAVHFHDTYGQALANTLAALRKGVTTVDASAGGLGgcpyaESAtGNLATEDLVWLL----DGLGVEHGVDLDALVETSRWMSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8IFJ3(21-285:313) Pyruvate carboxyltransferase n=3 Tax=Alphaproteobacteria RepID=B8IFJ3_METNO  E=1e-15 s/c=0.33 id=23% cov=47%
------------RDGYQGIGPFIATERKIELLGRLVAAGLRRIEIGsFVSATAlpqmRDTPDILAACKQFPDLEPQVLVPSERRGRDAVA-----AGARRLVFVLSVSEAHNRNNVRRAPEE---SADEYRRLLQAIPDDVAIRLDLATAFDCPFEGRIPEAktlallkrlvALKPDAE-ICLCDTTGRADPDHVGRLFSEAPSRFPEVKAWAL--HAHDTYGLGLANVHAAYREGVRIFDASFAGLGgcpfapGATGNVATEDLV----WMFERMGVATGVDLAALVSVAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2C751(11-311:313) Putative hydroxymethylglutaryl-CoA lyase n=3 Tax=cellular organisms RepID=Q2C751_9GAMM  E=4e-15 s/c=0.29 id=23% cov=50%
LPDAITVFEVGPRDGLQNEPHLSTLGGKataLKIALIneLGQTGLTHIESG-AFVSPKmiptmaDSDIV--FSHIQRHPNI--FYSALTPNLQ-GLEAAINVNANEVAIFTSCSETFTQKNIHASIDESLQRFESVIAIAHQHLIPVRAYLSCVIDCPYEGktlpqqVAEIAKTLIDMGCYQVSLGDTIGTGTPLRVANMLEYVNKHI---QSKAIAVHFHDSYGQALANIYQAIQMGITTIDSSIAGLGgcpyapGSSGNVATEDVI----YLCQGLNIKTGIDLEKLTLISQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8LAA1(25-285:377) 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bacteria RepID=HOA1_FRASN  E=4e-15 s/c=0.33 id=28% cov=43%
----LYVQDVTLRDGMHAVRHRYSVETARTIATALDASGVRAIEVahgdGLAGSSinygigaHTDWEWIEAVTASVTNAIPTSL---LLPGIG-TVRDLRQAHALGI--------RSVRVATHCTEADI---SAQHISAARDLGMDVAGFLMMSHMAAPAELARQARLMESYGAHCVYVTDSGGRLTMDDVRDRFRAYSDVLDPATET--GIHAHHNLGLGVANTVVAVENGATRVDASLAGQGAGAGNCPLEAFIAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JDD8(8-281:312) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Proteobacteria RepID=A3JDD8_9ALTE  E=5e-15 s/c=0.31 id=26% cov=44%
------------RDGFQSIHELLPTAGKIQCVQALIDSGITRIEIGSFVSSK----AIPQMADI--GNIVAAFSDHTGMRFSALVPNLKGADRALasgikeLVFVVSVSETHNQSNVRQSVDSSLDGLKTIADRLRSEKHSVRLRLDLATCFDCPYEGEIqwqqVDAVL-GKARNICkgielevaLCDTTGRATPYQVANHFTRLRER-HDSPSLKWAFHGHDTFGMGVANALFAVQHGATTLDASAAGLGgcpfapGATGNTATEDLIYALQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1BAX9(1-298:307) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Rhodococcus RepID=C1BAX9_RHOOB  E=8e-15 s/c=0.28 id=26% cov=41%
MTRpqRVQIREVGPRDGFQNEPEHIPTDDKVRLINALGRAGFTRIEVASfvrPDVIPQLADGVEVLSRIevPDETKLMVLV-PNSKGLDNALK--VRDKFHEVAIFVSASETHNKKNVNRTVDETMADNDVMAKRIVAEGLDCAAVIATSFGCPFEgkvDLTRVLDLAerfAEAGATEIGFGDTTGMCNPAYASEFFAAALDRLPG---VEVTAHFHNTRGQGLANAYAALEAGC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0QDG8(10-264:314) MvaB n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QDG8_DESAH   E=8e-15 s/c=0.33 id=27% cov=43%
------------RDGLQNETALVPAGAKVAFVDALSETGVSEIEV-SAFVSP-------RMIPQLRDAT-AVFQRIRRKkgviysalvpNI-KGFENAIAADVEKIAVFTAASETFNQKNINTTVDGSLDRFRPVVKQAgklglpvRGYISTAFWCAFEGKIAPGP-VVELTQRMMDMGIDEISISDTIGKATPEDVARLLDAL---LPKVPADRLAVHFHDTYGRGIANVLKSVSYGIGVVDASTGGLGgcpfapGATGNVSTEAVVAAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1D9E0(14-292:306) Hydroxymethylglutaryl-CoA lyase n=9 Tax=cellular organisms RepID=C1D9E0_LARHH  E=9e-15 s/c=0.30 id=24% cov=50%
------------RDGLQNESRSLPVGLRVELVERLVAAGLSVIEAGS-FVSPK---WVPQMAGTAE--VLAGIAPApglrlpVLVPNRQGLQAAMDAGVREIAVFTAASETFAFKNLNCSIGDslvrfapVIDEARLAGLRVRGYVSCVLGCPYEGSVAPER-VVDVSASLLKLGCDEISLGDTIGAGTPDTTRRLIRELAREVPVER---LAGHFHDTWGMAAANVYAAWLEGMRTFDCSVGGLGgcpyapGATGNVATEDLV----HLFDGMGITTGVSLAAVVETAHWISRQLGRQPASRAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3WDK2(3-277:302) Pyruvate carboxyltransferase n=6 Tax=Bacteria RepID=C3WDK2_FUSMR   E=1e-14 s/c=0.31 id=25% cov=48%
INNRIEIIEVGPRDGFQSIKEFISTEEKKKIIEGIIESGVKKIQLTS-FVSPKhipQMQDAEEIAKYFLNKypelEFSALV-PNYRGVKRAYEM----GLRNIAYVISVSEGHNKANVNRSVDE------SFVELEKILADfpDINITLDAATTFGCPFDGEVsydkvdsyVKRAYDLGIRTINLCDTIGISNPKQIDELLTILLEKYKDIE---FQVHIHDTRNMGMLNSYIAIKKGIKHVQASLGGMGgcpfapGASGNLSTEDFVYML----DKINIETGINFKKLVNIAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B3QVI9(3-227:510) Pyruvate carboxyltransferase n=5 Tax=Bacteroidetes/Chlorobi group RepID=B3QVI9_CHLT3  E=1e-14 s/c=0.37 id=25% cov=41%
------VLDCTLRDG--GYYTNWDFDGELvqKYFSSFEKLPVDYLEIGYRSLPEKEYRGrfyylpnfvIDEITQLSKNKLLA--IMLNEKSVQPKnLDKILDGLAPVISL----------IRLAVDPK-NFDSALLLGEAIRKRGFDVAFNLmyMSKYANDESFLGKL--SSLNGLASYVNMVDSYGGMVP----EQVKILIHNVKSYCREAIGFHPHNNMELAFANSLAAIDAGCEIVDTTVMGMGRGAGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A2U042(1-275:516) HMGL-like protein n=1 Tax=Polaribacter sp. MED152 RepID=A2U042_9FLAO  E=1e-14 s/c=0.31 id=24% cov=42%
MNKTFKILDCTLRDG--GYYTNWDFDRELvkTYCSSMESLPIDYVEVGY-RSIPlegylGEYfycpDFVmKELKQMMPSKKLVII--LNEKDIRASHvpELLKPCQGYISMIRIAVDPA--------NFERAIELAKAIKVMGFEVAFNVMYMSEWKEDNSFLDLLEDLDSIID----YFYMVDSFGG----VFQDDVKDIIRLVKSKTNVQLGFHGHNNLEMALANTITAINEGCEIVDATITGMGRGAGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8L5S6(32-340:360) Pyruvate carboxyltransferase n=29 Tax=Bacteria RepID=A8L5S6_FRASN   E=1e-14 s/c=0.27 id=24% cov=50%
LPESVTIYEVGPRDGLQNEASVVDVAVKAEFVRRLAGAGLRAIEttsfvpAAWVPQLADAAELLELLGPPPRGARRPVLVPNTRG-----LERALAAGAGEIAVFGSATETFARRNLNRTVDESLAMFEPVVTAARARGLAVRgYLSMCFGDpwegaVPPGQVAAIARRLVDLGVDELSLGDTIGVATPGHVEA--LLAELAAAGIGPGTLAVHFHDTYGQALANTLAALRAGVRTVDSSAGGLGgcpyARsaTGNLGTEDLVWMLH----GLGVGTGVDLGALVRTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8FDY7(3-281:302) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacillus pumilus RepID=A8FDY7_BACP2  E=2e-14 s/c=0.30 id=24% cov=49%
LPKRVLIREVGPRDGLQNESTWLDTSEKQRWIELLTAARLPYIEV---------TSFVHpKWVPALKDAK--ELAQSLHKKGDITYAALIPNEKGLAHffeanldtgaMFISSSETHNKKNMNQSIQEtlpvIKQMTADLKAAGKhtrAYISTV-FGCPYEHQVPMDQVLRLTEMLLSYGIDEISLGDTIGEAHPLQVERRLDILLERFP---ADKIALHFHDTKGMGLANIYTALKAGITIFDASSGGLGgcpyapGSSGNVATEDVVHML----QKLGIDTNINFPALIKAAEWIE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1Y373(18-281:311) Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y373_9BACT  E=2e-14 s/c=0.32 id=21% cov=46%
------------RDGFQGICDFIPTEKKVEFIGQMLSTGIKEMEITsfvSPKAIPQLSDAAQvlpAVKKEYPDVEFTALV----PNVKGAENAL-AAGADVVNVVFSVSESHNMANIRRTVEQSLsgmDDIIALVRGKAKICVSMATSFMCpfEGRIDPRRVAELIGKVRAKGVDCITLAETIGTCTPKDFTETLQVVK---PALEGIPTYLHIHNTYGFADMNVKCALDEGFNRFDSAVGGLGgcpfapGAAGNAATEDLV----YLMQSMGVDTGLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6GLP1(18-295:313) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Limnobacter sp. MED105 RepID=A6GLP1_9BURK  E=2e-14 s/c=0.30 id=23% cov=47%
------------RDGLQNEKTPISTAIKIELCKQLIEAGIHRLEAA-AFVSPK---WVPQMADGAD--VLAGL-QALPELQDRTVsysalvpnlkgmEAAIEAGVQEAVVFTAASEAFTQKNINCTIAESIERFKPVAELARAHNIHLRGSISCALGCpyqgevPVQSAAEVALRLRDIGVQEFDVADTIGVGTALRVSQVFEAVGYSV-GLQNVA--GHFHDTYGQALANILAALQLGVSTFHSSIAGLGgcpyakGATGNVATEDVVYLL----QGMGIETGLNLNKLVQT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI00015B4E2A(24-320:327) PREDICTED: similar to hydroxymethylglutaryl-coa lyase n=1 Tax=Nasonia vitripennis RepID=UPI00015B4E2A  E=5e-14 s/c=0.28 id=21% cov=50%
-TDIVRIVEVGPRDGLQNIRKVLPTETKIELINRLSQTGLRSVEVTS-FVSPKwvpqmaDSAEVYQGVEKNPNVEYSVLV----PNLKGLDKALK-LGVKEVVLFTAASETFNQKNINCSIAESLKNCKEITKICKEKKIKARAVISCIAGCPYEgeikpvNVANVAEALLDMGCYEVGLGDTIGVATPKKMAHLFEELKK-MTGGDVWRFAVHCHDTYGQAIANIYECLRQGIRVFDSSVAGLGgcpyapGASGNVSTEDLVYLLH----GEGFETGVDLDKLIQVGQFISE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5S7B1(12-249:327) Pyruvate carboxyltransferase n=2 Tax=Bacteria RepID=C5S7B1_CHRVI   E=6e-14 s/c=0.34 id=25% cov=42%
------VLDCTVRDGGLVNAHQFSDDFVRAVYRACVEAGIDYMEIGYknsPKVFPKEKFGPWRHCDEADLKRVVG-----DHDPEKTglkLAAMADAGKSdwETQIVpAAESPLSMiRVAFYA--HQVSE-AVDMIRYAHDLGYETTANLMAVSNITEAEIDTVLESIAPTPATTMVIVDSFGYL----YREQIDRLYRKYTSALEGTgkeIGIHAHNNLQLAFANTIEAIILGCNRVDATMYGFGRGAGNC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LRX4(4-266:311) Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LRX4_HALO1  E=7e-14 s/c=0.31 id=24% cov=42%
------LLDVTLREvGE-ASGYAFDIDDAIGLAQQLSAAKLDGVEIGYvrprawsgpPSAqtcSPT---YIERLRQALGSARLAVFVHLHEIPAGGLV-ALRPLGVDLIRLAVAA-----------DRPEILrERAAELRALG------IEFSVNAIRMTEHEPAriVELGRIAEDVGASMFYVADSNGSLYPLLFAKLAAQLRTEL----SIPLGAHLHDNLSLAMANAIVALSHGFEWIDGSLAGAGKGGGNLATERLALHLQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6HNN3(9-283:601) Pc21g09480 protein n=22 Tax=cellular organisms RepID=B6HNN3_PENCW   E=8e-14 s/c=0.30 id=28% cov=42%
----VRIVEVGPRDGLQNIRDSIPTSMKLELIKRLEETGLGTIEltsVVSPRRIPqladcrdvlGD-EGIRRMG--GKDLRLPVLVPTAKGL-DVAIEY----GVKEVAVFISATEGFSKANINCSVEQGIERARDVVSLAlksntvvRGYVSCIFADPYDGP-TQPASVLRCVKELLDAGCYEVSLGDTLGVGSPSNVRSLITFLLDN--DIPGEKLAGHFHDTYGQAVANVWEAYKCGLRVFDSSVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1TPI3(6-293:308) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPI3_9BACT  E=9e-14 s/c=0.28 id=26% cov=39%
LPSRVEIREVCPRDGFQSVKEKISTKDKIALIDAMAETGVSVMEVtSFVSpkaipqmsdASEVMTHFNERWSGKVKSVVLV-------PNVRGAENALKVSP-DSLNFVLSASASHNRANTRRTIEE----SLAELKEVKSLCGDVELGLSVATsfqcpfegAISPDAVVNIVEKAMEIGVGTVTLADTIGTCDPiylSLTLSQIKKVFGDYP------FFLHLHDTHGMAIINTMAAMEMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4XTF5(2-243:345) Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XTF5_DESMR  E=1e-13 s/c=0.33 id=23% cov=43%
--KNVTLLECTLRDG--AYKVDFMIDQETccAFAEKLVRIGFQDIEVGHGlglgayrqySAGFTDEALYKRLAPLAARSRLYSF---------------------FIPSVGKPDDFRMArdyglYGLRVGAEPVyVLDSIPTLEAAKSLGYFVALNVMKSYTVTPDGFAKLVETVKD-FVDVIYLVDSAGHMLPEELRAYVRAIQDRV---GMIALGYHGHNNLGLAVASALELLDEGVQYIDTTLTGIGRSGGNIPTETMLAVLAKKYGV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8TB92(74-364:370) Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=26 Tax=cellular organisms RepID=HMGC2_HUMAN  E=1e-13 s/c=0.28 id=25% cov=51%
LPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRwvpqmADHTEVMKGIHQYPGVRYPVLTPNLQG-----FHHAVAAGATEISVFGAASESFSKKNINCSIeesmgkfEEVVKSARHMNIPARGYVSCALGCPYEGSITPQK-VTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGA---LAVHCHDTYGQALANILTALQMGINVVDSAVSGLGgcpyakGASGNVATEDLIYMLN----GLGLNTGVNLYKVMEagdfICKAVNKTTN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1WMV8(4-300:314) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Proteobacteria RepID=A1WMV8_VEREI  E=3e-13 s/c=0.27 id=25% cov=52%
LPRRVHLHEEGPREGFQMEAGPIASADKVRLIEALARTGLREIQcVSFvnPGRVPGmaDAELVAQSIRKRQGVRYTGLwlnlrgmqrALGTPLDIEGTV-SISASEAFSVRNYGKGTAALLDAQ-RTTLAFCVEHAIAVTRASVTTAFGCNL--EGAicAATVVERVSQLLGLMDEFGlpLPILRLADTVGWAQPNAIASAIGAVRERWPALR---LGLHLHDTRGTAMANALMGLQMGIDTFDSACAGLGgcpfaghtGAAGNICTED----LAFMCEEMGIDTGVDLEALIECARLAEQIVGHPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0S6H7(3-278:289) Possible hydroxymethylglutaryl-CoA lyase n=3 Tax=Actinomycetales RepID=Q0S6H7_RHOSR  E=3e-13 s/c=0.29 id=25% cov=47%
----VTITDVVLRDGLQDEDVVVSTDHKIVVADALVAAGVKHIEAAS-FVSPT---RVPQMADA--DDVIARLPRT---DPSVTYSALALNPRGVhraiatgideIQVVTSASAGHSTANTGRNPDEALHGLAEALQKYPDRsflgGVSTAFVCPFEGIIAPAALVRVASAMAAMGVRRLGLADTLGTATTEQVLASAGAVRDALPD---VELSLHLHNAHGQALSTVIAAHRQlGITHFDSAIGGYGG-CpfapgahGNLATEELVAYLHAH----DIDTGIDQQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4Z863(12-268:323) HMGL family protein n=4 Tax=Bacteria RepID=C4Z863_EUBR3   E=4e-13 s/c=0.31 id=26% cov=42%
----IRVLDATIRDG--GLVNNFMFTDDFinALYRANVKAGIDYMEFGYKASKElfdvnkfgkwkfCDEAAIREIVgdnnSDMKISVMADVGRCDyKKDILPREDSVI--DMVRVATYVHQMPA----------------AIEMIEDAKSKGYEVTCNIMAISNTQESDLDQALDMVAKSSADGIYIVDSYGALYPEQIRRIAEK-YTEIAEANGKFVGMHAHNNQQLAFANTIEAAAQGVSLLDATMMGMGRGAGNCAME-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9HXH6(1-304:313) Strain DSM 12804, complete genome n=3 Tax=Bacteria RepID=A9HXH6_BORPD  E=6e-13 s/c=0.26 id=25% cov=52%
MTRDVVLCECFARDGLQHEARFIATPAKVGLIQRFADLGFDRVEATSysnPSVVPQFADASELLAGLPRRAGVwykatCANVRAVEralHDLDA------GHGANEISLLVSASESHSLRNLKRSRRDQWDNIAAMARRAAGRfrmvgTISVAFGCpfEGA-----VDAARVLDNArrfAELGVDLVTLGDTTGMASPPAVRNLYRTLQLEFPQMTLV---AHFHDTRGTGLVNYVAALDAGVRYFDSAFGGVgghpdkvkygGGHTGNVATEDLV----SLFESMGVRTGLDLAGLPAVSRLCQEALGRELHSRVAAAGLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0FNJ3(6-243:333) Conserved uncharacterized protein n=2 Tax=Erwinia pyrifoliae RepID=D0FNJ3_ERWPY  E=7e-13 s/c=0.33 id=28% cov=42%
----VILLDCTFRDG--GYYTNWNFDEDLvnIYYSAIIETDVDIMEAGYISVDASDcgrfkvenisgFNFLSVIpgkswAAMIDSKSILCLE--NWHDI--VIHILKKPARPVIDI------IRVATKFNQldNIDQLCNIISASGYRVALNLMQIDLACE-------EEVTAVFEKISSIKsIETVYLADSFGSMPPQRVAELI----TRLKEITSANIGFHAHNNMGMALINSMTAIQAGANWIDTTFAGMGRGAGNAATEEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6QTB6(1-287:564) 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase n=2 Tax=Trichocomaceae RepID=B6QTB6_PENMQ  E=7e-13 s/c=0.27 id=23% cov=49%
MTRpkvpEVRIVEVGPRDGLQSIKDAVPTETKTELIQRLWRAGLRSIE----LTSIVSTRKVPQLAdcqEILNNPAIRSLTEDSEASGLRlpvltpnlkGLDIALSRGVKEVAVFISATEGFSQANINCSVEQGVEKARAVAQKAieagiavRGYVSCIFVDPYDGP-TNPSSVLRCVQELLQMGCYEVSLGDTTGAGTPAKVATLIRYLEKNGVSLRN--LAGHFHDTYGQAVANVLQAYICGIRVFDASVGGLGG-CpfapgakGNVSTEEVV----FMFQNAGIQTGVNLEELVAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2RIA5(29-321:643) Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=15 Tax=Bacteria RepID=Q2RIA5_MOOTA  E=1e-12 s/c=0.26 id=25% cov=47%
---QLKITDTTLRDGHQSLWATrMTTADMLPIIEKIDSVGYHSLEV-WGGATfdvcmrfldEDPWERLRTLKKYARRTPLQMLLRAQslvgyqlyPDDVVRAFIARAAAnGIDIIRIFDALNDLRnMEVPVEAAKKEGV-HVQGTVVYTISPVHTTEH-----------YLKTALE-LESMGVDSICIKDMAGLLAPFEAYKLVKLFKEKL----HVPVQLHSHYIGGLAVGAYLEAARAGVDVVDTAsvplAFG----ASQPPVETVVRAL----EGTPYDTGLDLNLLFEIARY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q15RQ1(5-282:305) Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteria RepID=Q15RQ1_PSEA6  E=3e-12 s/c=0.27 id=25% cov=48%
LPSKVKIVEVGPRDGLQNEKASIDLVTKVTLIEALAKSGLSMIETGS-FVSPK---WVPQMADSA-----QVFAAINRQDtvIYSAltpnltgFEAALEAGADEVAIFGSASESFSQKNINCSIAESLARFEPVIAAAKAKNIKVRGYVSCVLGCPYEgeiapaNVASVAKTLFEMGCYEISLGDTIGVGTP--IATQI-MLNAVLDVVPLCAVAVHFHDTYGQALANILVALQLGINVVDSAVAGLGgcpyakGASGNVATEDVVYMLH----GMGIATGIDLSML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8P007(2-236:465) Oxaloacetate decarboxylase, alpha subunit n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P007_ERYRH  E=3e-12 s/c=0.32 id=25% cov=39%
----IKINDVTVRDGNQSLLATrMEHEDILKILAEMDQVGLNAIEVWGGATFDGALRFFKRspwqnlrdMKRVAPNTPFSMLLRgqnivgyhhydndTLERFIRLSLEN----GIDIIRVFDALNDI-----------ENVKNAIYFI---KKHGGHCQ-GAISYTVSPvhnIDYYVTYAKQLVEAGSDSICIKDMAGILLPDVTFELVKRLKEEL----DVPINLHSHATTGLSSLVFEQAMKAGVDIVDGCI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1Y2H6(3-278:300) Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y2H6_9BACT  E=4e-12 s/c=0.28 id=22% cov=47%
LPKKVLISEVAPRDGWQNHPVPIPTETKIKYIEKMVDCGARKMEITS-FVNPkyvpqmGDaREVFRGARSYLEEHGVTAFALTLN---QKGVENAREAGFTHVEFVLSVSE---EHNLRNSRRTIRESLDAFKELAANaeglhiilampcvfgspFGDEV----------PVERVKWLIDEAQSVGVAEFGIADTAGISTPENTRRVVTAIRE---YTDLSKVSLHMHDTYGMGLANCYVAMEEGITMMDSSLAGMGG-CpfvpgakGNIATEDLVYML----DKMGVETGYDLNKLNQTA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q46TI7(44-296:321) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Ralstonia eutropha JMP134 RepID=Q46TI7_RALEJ  E=5e-12 s/c=0.30 id=27% cov=22%
-----------------------------------------------------------------------------------------------------------------------------------------------------------ETLAAAGADDIVLCDTAGCADPRQVRRLTQAVWLAV-GVEGAP-GIHLLNTRGLGLANALAAVEAGMTVVHASLGGLG---GNV----VTEDLAFLLESIGIPTGIDLDALIAARTCVAQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8PPD2(1-225:624) Oxaloacetate decarboxylase alpha subunit n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PPD2_9SPIO  E=7e-12 s/c=0.33 id=25% cov=40%
MAHKVRISDLVLRDAHQSLHATrMTTADMLPICSKLDSVGYWSLEA-WGGAtfdacirflNEDPWERLRSLHKALPNTPIMMLLRGQnllgyRHYADDVVDAFVKAAAD-----NGVGVFRIFDALNDPR--NLKRAADA---AKKTGKHVQM-AISFATTPyhtIDKYAELAKTYTEFGADSICIKDMAGLLKPFDAFDLVTAIKKKT----SIPINIHTHATTGLSVATLLKAAEAGAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2VQL9(75-357:422) Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VQL9_NAEGR   E=1e-11 s/c=0.26 id=26% cov=49%
MPSFVKIVEVGPRDGLQNEKklVPTNV--KISLIDKLTEAGLPSVEVTS-FVSPkwvpqmGDnFDVFTGIKRRegtaypVLTPNVKGLEQALE------------AGVKEVAIFLAASDAFSMKNINCTVEEsfkrydqVMELAIKNDLKIRGYVSCVAGCPYSGYVSP-ETVAQVSYRLLKMGCYEVSLGDTIGVGTPGSVSMLLHQVCKKIPTGQ---IAVHFHNTYGQALSNILTSLQFGVETVDSSVAGLGgcpyakGASGNISTEDVVYMLH----GMGINTGVDLDKLIDAGDYISTYLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q28T96(1-274:284) Hydroxymethylglutaryl-CoA lyase n=8 Tax=Proteobacteria RepID=Q28T96_JANSC  E=2e-11 s/c=0.27 id=28% cov=42%
MTEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVAS-FVSPKwvpqmaDGADVLAGITRAPGVSYAALTPNMRG-----YDGALGAKADEIAIFASASEGFSKANLNATIAESLvrfadvaqaarAAGVPMRGYVSCVT-QCPFDGE----TPPENVARVAAALRDMGAYEISLGDTLGRAYP---AQVDAMLAAVLPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1DTS7(20-314:647) Pyruvate carboxylase subunit B (Pyruvic carboxylase B) n=9 Tax=Bacteria RepID=C1DTS7_SULAA  E=3e-11 s/c=0.25 id=22% cov=41%
-PKPIKITDLTPRDGQQCkLATRVRTDDLLPLCEKMDKAGFYAVEV-WGGATfdvclrylkEDPWERLKRIKEVMPRTKLQMLFRG------QNIVGYKPKSDKVVKKFVEKAIEHGITVFRVfdSLNDNRNIEV-AVKAIKEFGGEV-HAEISYTKSPVHTLEKwmsYADELIDLEPDWICFKDATGILMPEDTYNIIRGIKQKIKEKanDRIKLVLHNHDMSGTAIMNHMMAILAGVDMV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1C8U1(1-274:522) Pyruvate carboxylase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C8U1_SPHTD  E=4e-11 s/c=0.26 id=23% cov=40%
MTSRIQLIDVTLRDGNQSLwsATGIDTETVLAVAPLLDQVGFKALD--FTTSThmaisvryhqEDPFERIRLTSQLMPNTPLIFMTTgmrfitwepAPRAIIRLAMQLVIKHGIRRIQIVEPMNnmPALLEAA-KIAREEGAEQVVAGLVYSISPVHTDEFY--------------VGCAAALAGAtdliDTVYIKDPSGLLTPERVETIVPAMRKAL---GSMPLEIHSHCNAGMAPLCYLRAAELGVETVHTAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7U935(5-268:540) Possible HMGL-like family protein n=1 Tax=Synechococcus sp. WH 8102 RepID=Q7U935_SYNPX  E=6e-11 s/c=0.27 id=22% cov=42%
------ILDCTLRDG--GYYNNWNFSDELieNYVRASLAAKIDVIEIGFrsslnnkfkgACAYSSDlflenlpFLNGTDIAVMVNGSEIC-----RTDSIPRLLEKLfpKPAISSIVSI--------VRIACHFSE---LSRVLSATRWLADHGYKICINIMQISDRKYADIKEITSMASDCPIDVLYFADSTGSLKPDDISRIVEWFRTGWQRE----LGIHTHNNMGIALQNTLRAYEEGVNWLDSTVSGMGRGPGNAKTEELVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q88LY5(4-247:534) Aldolase/synthase, putative n=6 Tax=Proteobacteria RepID=Q88LY5_PSEPK  E=7e-11 s/c=0.29 id=24% cov=44%
-------LDCTLRDG--GYYNNWNFSEAL-IAQYITAMqaaGIQTIELGlrslknssFSGACAYTTDAFLSTLDLPPSMTIGVMVNGSELVG-------KNAGQQALQLLFPSpaseSPVDL-VRIACHVHEFAE-ALPAASWLKERGYDVGFNLMQIANCSESEIKALAKLANNYPLDVLYFADSMGSMSPDDAAQIIQWLRSEWQG----ALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGMGRGPGNARTEELAIEIAAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8ZRW8(27-299:681) Conserved carboxylase region n=6 Tax=Bacteria RepID=A8ZRW8_DESOH   E=9e-11 s/c=0.26 id=25% cov=43%
------IMDLSLRDGHQSLFATRGrTEDMLPVAGLMDEVGFWAVEV-WGGAtfdtmhrflNEDPWERIRTLKRYFKKTPLSMLLRGQNlvgyrnyaDDVARAfVERAAENGMDVFRTFDALNDFR-----------NFETVVEVIKKCGKHFQGTI----CYSMTEPrlggevynvEYFVTKAKELESMGADTICIKDMAGLVAPYDIFNVVKALKESV----KPPIHFHSHFTSGLAPMSHLKAVEAGVDILDTCLSPYAYRTSHPAVEPMVMSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0CWY1(8-292:552) Hydroxymethylglutaryl-CoA lyase, mitochondrial n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CWY1_ASPTN  E=1e-10 s/c=0.25 id=23% cov=50%
----VRIVEVGPRDGLQNIKDPVATSVKLELIRRLRESGLSTIELTS-IVSP---RAVPQLAdcrEVLRDQTIKQLQQhdglrfpvlvPNPKGLDIALEY----GVKEVAVFVSATEGFSKANINCSVGEGIERASRVAEKAIRNGVAVRGYvsciFEDpfSGPTKPSAVLRCVKALLSMGCYEVSLGDTTGVGRPETVRELLTYLVDN--SIPVERLAGHFHDTYGHAAANAWEAYTCGIRVFDSSVAGLGG-CpfapgskGNVATEDLV----FMFHNAGVDAGVNLLKLMETGIWISRILG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q11V59(15-286:289) Hydroxymethylglutaryl-CoA lyase like protein n=26 Tax=cellular organisms RepID=Q11V59_CYTH3  E=2e-10 s/c=0.26 id=21% cov=46%
------------RDAMQG-IIPFIPTEvKAKYINTLLRCGFHSIDFGsfvSPKAIPQMKDTADLLDLLQLDGERAALLSII-ANERGAEQALTYSEIDYLGFPLSLSETFQQKNTNKSIDEAM-RTVDAIQHlcIRQHKNLVVYLSMGFGNPYGEAyspatVIDFVKQLDQLEITTISLSDTIGSSEPELIKNLFRTLQASYPHIE---FGAHFHSRPETAKRKIQAALDAGCKRIDSTILGIGgcpmakdELVGNINTEVLLEELETRAIPSGIHT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1MF23(20-300:419) Possible 2-isopropylmalate synthase n=1 Tax=Mycobacterium abscessus ATCC 19977 RepID=B1MF23_MYCA9  E=2e-10 s/c=0.25 id=24% cov=43%
------ISDETMREGGERAPFGATDDQKIQLIRAITDAGITDIDVGSGI---TEASFVRALLDaQQLESTIAPDATFSFNLTLKTWEPLcEQLERELPSSYL--SDIYVSIGMieidseNRLFERVAERLRSiGVGKLRSSLLNA------FSITVDEQKYEHLNTQIErcrqQGISLIRINDSVGTLVPDSTAVLAANL---VRDNPDITFYLHGHNDRGLGTANSLTSVFHGFQMIEGGVAGVGNRSGLAEIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9P3J2(55-376:395) Hydroxymethylglutaryl-CoA lyase n=5 Tax=Sordariomyceta RepID=Q9P3J2_NEUCR  E=2e-10 s/c=0.22 id=22% cov=50%
---RVKIVEVGPRDGLQNEKKSIPLATKIELIERLAKTGLQTIEAG-AFVSPKwvpqmansDeilehllktpppspvpltFSFLAPNTKGLESA-LSILGKypdAYETETTRSGKSAQEGGKPAleIAVFAAATESFSQKNLNCSIDaslrqfkEVIQQAKQANLRVRAYISVVLGCPFEGYDVDPHRVAAIATDLLEMGADEISLGDTTGMGTAPRTKELLNCLS--LAGIRNEDLAMHFHDTYAQALVNTAVALEHGIRTFDSSVGGLGgcpyspGATGNVATENVV----YFMESLGMDTGVDLDRVADI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2UP73(9-238:507) Methylmalonyl-CoA carboxytransferase n=4 Tax=Verrucomicrobia RepID=B2UP73_AKKM8  E=9e-10 s/c=0.29 id=24% cov=41%
---------TVLRDGHQSLAATrMKTADMLPIAPILDSMGFSALET-WGGAT---IDAGLRFLKEWPFDRLDALKKAAPKtphmmllRGQNIVGYTNYAD-DVVEAFVAMSAKHGMNIFRifdcvNDPRNMETSIRAAKKAGAQAHGTICYttSPVHTTQTFVD----MGRELADMGADAIVIKDMAGLIPPYVTQELVSALKKDL----NIPVWIHTHDTAGLGASTYLSAIDAGVDACDVSIspfaNGTG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0IC26(1-237:355) 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0IC26_VIBHO  E=1e-09 s/c=0.29 id=27% cov=40%
------ILECTLRDGSYEIDFQFSKKQTSDICKALDTAGFELIEVGhgvGLGASeknigvalETDEVYMEAAANNVKNGKwgmfaIPGIAEKHHLDI--------------------ASDYDMDFIrIGSTIEDFPKSS-EFIDKAKSLSMMTCVNFMKSYTSKPEKLAIASSAAFEMGVDVVYVVDSAGGMLPNEVKNYVEAIKA---ENTNAIVGFHGHNNLGLGIGNALAALNAGASIIDTSLQGFGRSAGNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1ZLV9(65-387:407) Whole genome shotgun sequence assembly, scaffold_57 n=1 Tax=Sordaria macrospora RepID=D1ZLV9_SORMA  E=1e-09 s/c=0.21 id=23% cov=50%
---RVKIVEVGPRDGLQNEKKSIPLATKIELIERLAKTGLQTIEAG-AFVSPKwvpqmanSSEILEHLLKTPPPSPVpltYSFLAPNTKGLDSAFSLLsqypkafetetagrsskvaQEGGKPAleIAVFAAATESFSQKNLNCSIDtsltrfkDVIQQAKAANLRVRAYISVVLGCPFEGYDVDPHRVASIATTLLEMGADEISLGDTTGMGTAPRTKELLSCLSS--AGIRNEDLAMHFHDTYGQALVNTAVALEHGIRTFDSSVGGLGgcpyspGATGNVATENVV----YFMESLGMDTGVDLDRVADI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4Z4L3(13-248:326) Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z4L3_EUBE2  E=1e-09 s/c=0.28 id=24% cov=41%
----IKVMDCTLRDGGLVNNFEFTDEFVKDLYEANVAAGVDYMEFGYKADkdifDEKEFgkwkfckeEDIRAIVGEndtpLKISVMADVGRTnMKRDIPPKSESV--VDMVRVATYINTIPA----------------AIEMANYCSDMGYEVTVNIMAISTAgENELDLALELLASQSKAQYIYLVDSYGSLYPEQVRRLADKYIK-IAEKYGKSVGIHAHNNQQLAFANTIEACSIGVSLLDATVSGMGRGAGNC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0WAZ1(25-287:465) Oxaloacetate decarboxylase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WAZ1_9FIRM  E=2e-09 s/c=0.25 id=26% cov=34%
----VRLVSCDLRDGQQAAIATrMTTEEMLPVLKPLDEFGFDALEV-WGGAtfdacirflGEDPWERLRIIKAHVKKTPLRMLLRgqnllgyAPYPD-DVVDHFVAAAARDGIDIFL------IFDGLN-DVRNVRRAAEAALKAGKKVEANLQFtsSPvhtvESFIKTARDYL--------DIGATALHLEDMGGMKTPREAVETVKALKATF----DVPVHYHAH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4HR83(3-204:330) 4-hydroxy-2-ketovalerate aldolase, putative n=2 Tax=Campylobacter RepID=Q4HR83_CAMUP  E=4e-09 s/c=0.32 id=28% cov=36%
----IQILDCTLRDGSHINNGKFG-KEKIRqIITGLIEANIDIIEVGllqnhqcgvdFSIFNSIDFvdQCLSSIEK--KNSKFSLMLRTDRVDFNKLAKSPK-VDFIRIALY----------------QEHLNDIKRYGEKAKELGYEIIFNPiaiTKYSPNEIQFLIKTLEELKPYG---ISLVDTFGSFTLNEFEKVLKIFDKNL--SPNITLGIHLHQNLNLAL--SLAA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1B6M4(44-317:507) Pyruvate carboxylase n=2 Tax=Synergistaceae RepID=D1B6M4_THEAS   E=6e-09 s/c=0.24 id=27% cov=39%
-PRRIGITETAFRDAHQSIMATrLRTEDMIPIAEAMDQVGYHSMEV-WGGAT---FDACMRFLDEdpwerlrelrrrMPNTKLQMLLRgqnlvgyrhyaddVVREFVKRAV----GNGIDIIRIFDALNDLR-----------NMEVAADQVKREGAHLQLAI----SYTISPVHTLESFVKQAEDmvsMGADSICIKDMAGLLSPTEAGKLVSAIKSRIGR---VPLQVHSHYTSGFAAMTYLASIMAGADVVDCAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6MHG9(1-303:311) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHG9_BDEBA  E=7e-09 s/c=0.21 id=25% cov=50%
MKKSVVIVEMGLRDGLQNEKTVLDADTRVEFARRLILAGTKRVEIG-AFVSPtwvpqmaGTAEVVQKTFALVKSGSIpkkTEFSVLVPN--ERGMMDAIASGVKEVAIFAACSESFSLKNINCSIDESFKRFEPVMALAKKHKIKVRgylstcFGCPFEGRVSEAKVVKLAQRMHKLGVYELSIGDTIGVADVGQVESLFRKLKKVVPVKKLAG---HFHDTRGQALANILAAYKLGINVFDTSLGGLGgcpyapGATGNVATEDVV----YMFHGMGVKTGLNLDKLIEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6KI73(53-294:451) Hydroxymethylglutaryl-CoA lyase, putative n=3 Tax=Toxoplasma gondii RepID=B6KI73_TOXGO  E=8e-09 s/c=0.27 id=24% cov=43%
--PKVRIVEVSPRDGLQNEEKVLSLDDKITFINMLETAGLSTIEIAS-FVNPvkvpqmADAAALtRQFCSRSKN--IGGLSPTFQVLVAnmRGFEEAAEAGAQEISLFTATTDAFCRANINTTVSESLKkfsvIAREAADRGIKTRGYVSCIFECpyQGKVAPTTVVQVARHLLDMGCYEVSLGDTLGVGTAGPTLNLMEELHRN--NFPMETVAMHLHDTYGQALANILVSiVHGGVRVVDTAVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4ELN2(15-293:298) Hydroxymethylglutaryl-CoA lyase (Fragment) n=5 Tax=Proteobacteria RepID=A4ELN2_9RHOB  E=8e-09 s/c=0.23 id=24% cov=38%
----VRIHEVGPRDGLQNEPSVISVARKVALIDLLSQSGLRDIEVGS-FVSPKwvpqmaDTDQVLAQLSPVQCVRYAVLV-----PNKRGWDGFLDARRDdiitDIAVFIAASEGFSQSNLNCSIAESVDRLRPVVAAAKETGVTVRGYVSCVTDCPFDGptspqqVADTVAMLRDLAPMQISLGDTIGQGTPDRISAMLEAVLAVAPATD---LAGHFHDTGGQALAN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5BD63(15-277:303) Putative uncharacterized protein n=1 Tax=Edwardsiella ictaluri 93-146 RepID=C5BD63_EDWI9  E=2e-08 s/c=0.24 id=20% cov=46%
------------RDGFQNVRDFIPTALKIEIIEGIISAGVQRMQLTS-FVSP-------AAIAQMRDAEIISR-HCIPRYPDRQFSALvpnfhgarlaQACGYREITPVISLSETHNLKNVNKTHRQSLDEIARIRQsfpevHIVQDIATV-FGCpyEGRMATPP--LLALITALTAEGIDEFTLCDTIGVAYPEQVLSTLNAVRSAFP---AVKLNIHIHDTRNMGIINSYLAAAWPVDAIQTSLGGLGgcpfapGASGNTATEDLVYLLHAQ----GMATGIDFSRLLATAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4ZRW6(3-196:342) HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=Q4ZRW6_PSEU2   E=5e-08 s/c=0.32 id=22% cov=34%
----VKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSfapKGE----HGLTSDVGAVFIEKIAQAAKGRIELAV---------MVHPRNITTD-----DLAMLKEQGVSMIRVCLRrdqldeglvtlsLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLFSRLSSRLL----VPLGFHAH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2W8A2(32-377:395) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Pleosporineae RepID=B2W8A2_PYRTR  E=7e-08 s/c=0.18 id=22% cov=52%
-ADHVRIVEVGPRDGLQNEKKTIPLATKIELVERLARTGLTTIEAGS-FVSPKwvpqmanSAEILERLLSSPPHSShpityqwllpnVKGFdnflstwqsksqsghdayptpppspgtdngpaLNTSSSDPNAMPSASSGADAmnknhnstPPIHelsIFTAATESFTQKNTNCSIAESLKRFEPIMSKAKEMNLNVRAYISVALGCPYEGpdvdphkVAELAVSLLEMGADEISVADTTGMGTAPKTLELLKTL--NAAGVDKSDLALHFHDTYGQALVNSVVALEHGIRTFDAAVGGLGgcpfspGATGNIATEDLV----HCFHSLGAKTGVDIEKLSEVGEWISQELGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0CVP8(3-257:336) Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVP8_9CLOT  E=1e-07 s/c=0.24 id=20% cov=42%
---KIHLLDCTLRDGGYVNNWEFDNGVAKEIVNGLYKSGIHVIEIGImghggkVGKS-TKFASFKEAESLLEN---------RKKDCKYAI-MLNQAEAASFDIPArseKTVDMIRLAYFKSE----FQNAIVLAKSLKDKGYEVFLQAMaTFMYSDDE-MNDMLRQINDMKPKAFYIVDSFSNLFPEDIARMAKQVLLKLDK--DIDFGFHAHNNIQMAFSNAITFMDVESDRdiyIDGSIYGMGRGAGNVPIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P32327(559-827:1180) Pyruvate carboxylase 2 n=326 Tax=cellular organisms RepID=PYC2_YEAST  E=3e-07 s/c=0.22 id=27% cov=41%
-----LLMDTTWRDAHQSLlatrvrthdlaTIAPTTAHALAGAFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRgangvAYSSLPDNAIDHfVKQAKDNGVDIF------RVFDALN-DLEQ-LKVGVNAVKKAGGVVEaTVCYSGDmlqPGKKYNLDYYLEVVEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRTRYPDL---PIHVHSHDSAGTAVASMTACALAGADVVDVAIN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3ASA1(2-238:650) Oxaloacetate decarboxylase, alpha subunit n=35 Tax=Bacteria RepID=Q3ASA1_CHLCH  E=4e-07 s/c=0.25 id=23% cov=41%
--KKIRFMDVSFRDGFQScYGARVRTEDFLPVLEAAVAAGTDNFEIGGGARFQSlyfycEEDAFEMMdrAREVvgpdinlqtlsRGANVVGLISQSRDIIDLHARLFKKHGISTIRNFDALMDVrnlaysgQCIHNAGLKHQVVIALMGLAPGLKETYCHTPQFY--------LDKLQEILDTGI--PFDSVAFKDASGTTTPATVYETVKGARKMLP--SETVIEFHTHDTAGMGVACNFAAIEAGADII----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q07TZ1(532-800:1149) Pyruvate carboxylase n=41 Tax=Bacteria RepID=Q07TZ1_RHOP5   E=4e-07 s/c=0.22 id=27% cov=45%
--KRVLVTDTTMRDGHQSLLATrMRSHDLVEVAEsyatglpqlfSLECWGGATFDVAMRFLTEDPWERLSQIRERVPNILLQMLLRgangvgyTNYPD-NVVRFFVREAAKGGVDVF------RIFDALNWM--ENIHPAIDAVasenkiaEAAVCYTGDI-LDPDRAKYS-LKYYVDLAKEMERAGAHILGVKDMAGLLKPQAAKVLFKALREEI----QIPIHFHTHDTSGIAAASVLAAVEAGVDAVDAAMDALSGLTSQPCLGSIVAALK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6UE85(569-842:1184) Pyruvate carboxylase n=111 Tax=Bacteria RepID=A6UE85_SINMW   E=4e-07 s/c=0.22 id=29% cov=45%
--KEVLITDTTMRDGHQSLLA--TRMRTYDIARIADT---------YARALPGLFS-----LECWGGATFDVSMRFLTEDP---WERLamvrEGAPNLLLQMLLRGANG---VGYKNYPDNVVK---YFVRQAAKGGIDVFrvFDCLNWvenMRVSMDAVAEenrICEAAIcytgdilnsarpkydlkyytalaaeleKAGAHMIAVKDMAGLLKP----AAARVLFKALKEATDLPIHFHTHDTSGIAAATVLAAVESGVDVVDAAMDAL---SGNTSqpcLGSIVEAL----SGSERDPGLDPEWIRRIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2F685(26-310:338) Hydroxymethylglutaryl-CoA lyase isoform 1 n=2 Tax=Bombyx mori RepID=Q2F685_BOMMO  E=8e-07 s/c=0.20 id=24% cov=49%
-APEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVESAS-FVSPK---WVKQMSDSVD----------VMKNIQRVpgvnypvlvpnlkgYETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEEglrrfkqVADEAVRDGLRVRGYISCVVGCPYDGPIHPKN-IAKITEQWIAMGCYEVSLGDTMGVGT---AGSVRRLLHEILTVAKPEQLALHFHDTYGQGLSNLLAGLELGIKTVDSSISGLGgcpyARgaSGNLATEDLVYFLY----GLGVNTDVDLVKIIEAGRYISNFLGKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P13187(3-272:596) Oxaloacetate decarboxylase alpha chain n=404 Tax=cellular organisms RepID=DCOA_KLEPN  E=1e-06 s/c=0.21 id=21% cov=40%
----VAITDVVLRDAHQSLFATrLRLDDMLPVAAQLDDVGYRSLEC-WGGAT---FDACIRFLGEDPWVRLRELKKAMPKtplqmllRGQNLLGYRHYAD-DVVERFVERAVKNGMDVFRvfdaMNDPRNMQAALQAV---RRHGAHAQGTL-SYTTSPAHTLqtwLDLTEQLLETGVDSVAIKDMSGILTPHAAFELVSEIKKRY----DVTLHLHCHATTGMAEMALLKAIEAGVDGV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5EHC6(33-251:465) Pyruvate carboxylase subunit B n=2 Tax=Clostridiales RepID=C5EHC6_9FIRM  E=2e-06 s/c=0.26 id=20% cov=38%
------------RDGQQSLFATrMTTADMVPLLSAMDQVGYDSMEM-WGGATfdvavrflkedPWDriREFKKYVKRTPLKMVLRGqnLVgyKAYPDDvVEKFVEKAAAAGIDVFLIFDALQDLRnCESAFRAVKK-AGKKIEGSIQYNISPFHTIEKFVENG------------KEQEKMGVSLLHVEDMAGLMTPAAAYDLIKALKAEL----KVPIHLHCHCTGGMAEMAYWEAIRAGVDGLDVCV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q12KS9(6-247:539) Pyruvate carboxyltransferase n=2 Tax=Gammaproteobacteria RepID=Q12KS9_SHEDO  E=2e-06 s/c=0.23 id=21% cov=45%
------ILDCTLRDGGYYNNWDFCPEVVSAYLDAMAKSKIDYVELGlrnFP---KKGFDgpFAYTTESFLKGLGLpSGPTYGVMVDAKTVLDAPMTIEQAIDKLFVdaSKSPIKLVRVAAHFHE--VEHSGPIVKALKAKGYIVGYNLMQAGGKPNEVIAAKAKVASQwNSLDSLYFADSLGNMD----ATEVTRIVKALRTEWSGDIGIHTHNNMGKALDNTLTAKELGVNWLDVTVTGMGRGAGNAQTESLLAVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2V325(528-802:1146) Pyruvate carboxylase n=9 Tax=Clostridiales RepID=B2V325_CLOBA   E=3e-06 s/c=0.20 id=24% cov=45%
---KLLLTDTTMRDAQQSLMATrVRSKDMKNIAKATALYGNDlfSLEMWGGATFDTAYRFLKEspwrrldsLRKRIPNVMFQMLIRGANGVGyknypdNVIREFIKESANSGIDIFrIFDSLNWLKG-IEVSLEEVLK-ANKVAEVALCYTGDIL----DENRDkySLKYYVDKAKEIEKMGAHILAIKDMSALLKP--YAA--KKLITALKNEVSIPIHLHTHDTTGNGVATVLMAADAGVDIIDTTFNSMSGLTSQPALNSIVAALN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O27179(4-273:568) Pyruvate carboxylase subunit B n=36 Tax=cellular organisms RepID=PYCB_METTH  E=4e-06 s/c=0.21 id=19% cov=47%
----IKVVETAFRDAHQSLLATrLRTRDMTPIAEEMDRVGFFSLEA-WGGAtfdtcirylNEDPWERLRELKEHVKRTPIQMLLRgqnlvgykhypddIVRKFIEKSYEN----GVDVFRIFDALNDIRnMEYAIKVAREQeaHVQGVIC-------YTISPYHTLESY----VDFAREL--EALE--CDSVAIKDMAGLISPHDAYELVRALKEET----DLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQPPTESIVAALR----DTPYDTGLDLEILKNIKKYFEEI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1ZXN8(525-913:1165) Pyruvate carboxylase n=5 Tax=Bacteria RepID=B1ZXN8_OPITP   E=1e-05 s/c=0.14 id=23% cov=47%
--KRLLITDTTLRDAHQSLMATrVRTYDMRAVADALAHHapGLFSLEM-WGGATfdtamrflyEDPWDRLRQLRAAVPNIcfqmllrganavgytnypdhVVAGFVRhaaSAGMDIFRIFDSLNYLPNLRVAM------------------EAVQDTHAVCEAAICYTGDIL----DGKRDkfSLQYYVKLARELERMGAHFLAIKDMAGLCRPYAAYKLVKALREEI----GLPIHFHTHDTSGIAATSVLRASDAGVDVVDLAIASMSGSTSQPNLNSIVAALQHTPR----DPQLDLERLNAVSDYWEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q583A8(18-318:431) 3-hydroxy-3-methylglutaryl-CoA lyase, putative n=5 Tax=Trypanosoma RepID=Q583A8_9TRYP  E=0.0001 s/c=0.17 id=21% cov=41%
------------RDAMQGLPHFIPTEQKIRYLKALLKCGFYALDCGsfvSPRAVPQMRDSTEVIANCWKTmqeekaapklsvvvASLAGFKQALETPGVSVIGYPIGCCERFQQRNAKKSIA-------MSLDEIRNIKEATDAFNAQRSsnpvapnEDVNgrelliYISMAFGNpygesHSIDLVEKLVGELVASGARDISLADTTGVAQPPLIFDTFTQLRKKFPD---VTFAGHFHSNAVEARGKIVAALDAGCTMIDSALCGMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8J4F8(1-515:515) 2-isopropylmalate synthase n=3 Tax=Desulfovibrionales RepID=B8J4F8_DESDA  E=1e-167 s/c=1.15 id=48% cov=98%
MNNRVYFFDTTLRDGEQSPGATMNLQEKLRLAHQLEVLGVDIMEAGFPASSPGDFESVQRIAAQAGDIQVAGLARCVAGDIDRCWEAIKNARNPRIHIFLSTSPLHMRHKLRKDPDDVLRMAVEGVKRCAMYTDNVEFSCEDFSRSEPEFLCRVVEAVIKAGATTVNLPDTVGYAQPAEYAARIEHVISNTPNSDKAVFSVHCHNDLGLAVANTLAAFRVGVRQAEVTLNGIGERAGNASLEEVVMNLRVRQDYFGLEHNIVTEQLYPSCRLLSMTIGQPIPNNKAIVGANAFAHESGIHQDGMLKNRETYEIMTPQSVGRTESNLVIGKHSGRNAVRNKFEAMGYKLDDDQLNLIFEAVKQLADRKKNLHDDDLMALVQEEIYRA-PDRFRLRHVSVQSSDtgGVPPTAAVIMDVDGKESSGAGFGVGPVDALFNVIADMVGREAELEQYAINAITGGTDALGEVTVRLRDGEYSAVGRGTHPDIFVASARAYVNALNHLAKKEEEGPRLH--CQHD-------
>UniRef50_B8DM91(5-502:514) 2-isopropylmalate synthase n=31 Tax=Bacteria RepID=LEU1_DESVM   E=1e-165 s/c=1.17 id=51% cov=95%
-SGRIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQGDFEAVQAIARAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYKLRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVPDTVGYAQPEEFGRLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTISGIGERAGNASLEEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVGANAFAHESGIHQDGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGYRLEEAQLVTVFEAVKKLADKKKQIYDEDIEALVLEEVYR-LPDLYRLVNLSVQCsDTGMPPTAAVVMDVMGEVKRAAGFGVGPIDAVFNVIGEIVGRAPVLERYSVTAITGGTDAQGEVTVRLRQNGSSAVGRGSDPDIILASARAYVNALNRL------------------------
>UniRef50_Q9C550(84-610:631) 2-isopropylmalate synthase 2, chloroplastic n=59 Tax=cellular organisms RepID=LEU12_ARATH  E=1e-157 s/c=1.06 id=47% cov=95%
----VRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAETVGNtvdengyvPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKKSKEEVIEIARNMVRFARSLGcEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGITLPSEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTINGIGERAGNASLEEVVMAIKCRGDHvlGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNdagIVLGKLSGRHALKDRLNELGYVLDDGQLSNLFWRFKAVAEQKKRVTDADLIALVSDEVFQPEAV-WKLLDMQITCGTLGLSTSTVKLADsDGKEHVACSVGTGPVDAAYKAVDLIVKEPATLLEYSMNAVTEGIDAIATTRVLIRGDnnysstnavtgesvERTFSGTGAGMDIVVSSVKAYVGALNKML-----------------------
>UniRef50_Q5F8D4(4-502:517) 2-isopropylmalate synthase n=73 Tax=cellular organisms RepID=LEU1_NEIG1  E=1e-156 s/c=1.11 id=45% cov=95%
-ANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWSANRLSLGKLSGRNAFKTKLADLGIELeSEEALNAAFARFKELADKKREIFDEDLHALVSDEMGNMNAESYKFISQKISTETGEEPRADIVFGIKGEEKRASATGSGPVDAIFKAIESVAQSGATLQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGADTDILAATAKAYLSALSKL------------------------
>UniRef50_B4SI67(9-515:528) 2-isopropylmalate synthase n=45 Tax=Xanthomonadaceae RepID=LEU1_STRM5  E=1e-150 s/c=1.05 id=43% cov=96%
-TPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMALIGRELRRPslSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTINLPDTVGFTTPEEIREMFQQViagVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLEEDELKLVFEQFKGLCEQQRVVTDADLQTLM---QGGSNAQGYRLASMTI-SDVGSRANALVELSDpDGNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEYDGTGTSKDIIEASALAWLDVANRLLRQRQAN-----------------
>UniRef50_UPI0001C41E20(15-509:511) 2-isopropylmalate synthase LeuA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41E20  E=1e-144 s/c=1.04 id=37% cov=94%
IPDEIKIFDTTLRDGEQAPGIALTVDEKIKIAQRLDELGVNVIEMGFPTVSSGERKAAREMVSLGFSSELCGLARVVQKDID----ALIDSDLSYAHLFIGTSPLHRDYKLKKSKTEILSQSMEMVEYAKDHGLKVEFSAEDATRTELNYLIEFYKGVESAGADIINVPDTVGILVPSTTRTLIRTLRKKI----NLPISLHFHNDFGLAVSNSLIGIEEGANQAHCTINGIGERAGNTSLEELVVSLKI---AYGANLTVDTTKLYDTSNFIGSITGIKMPPTKPIVGDNAFAHESGIHVDGILKNSSTYEPIAPEIVG-HKRRIALGKHTGHAAIKSKLEEFNIEVTQKQFDNIYNQVKTLGDKGKCLTDDDLRSIAITEIGTSGKEYIKLLGLSVMTGESVSATATIKLSIDGKIMETSQIGVGPVDASVLALKTLVQdrVNISLDEYRLEAITGGTDALAETFVVISDDkGNKATGRATREDVILSSVIAVINSINRILDIQE-------------------
>UniRef50_O66682(1-525:528) Uncharacterized AIPM/Hcit synthase family transferase aq_356 n=44 Tax=Bacteria RepID=LY41_AQUAE  E=1e-136 s/c=0.93 id=32% cov=96%
MAEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQKAKKMnFKNAKLTAFGSTRRPNkkvsEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTLEENLNMIYETVEYLKRYVDEVIFDAEhffDGYKSNPEYALQVLEAALKGGADWVVLCDTNGGTLPHEIYEITKKVKERFKDAN---VGIHAHNDSETAVANSLMAVLAGARQVHGTINGIGERTGNANLCSIIPNLQLKLG-FDVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESAFAHKGGVHASAVLKNAKTYEHINPELVG-NKRKITVSDLAGRSNLVHKLKEFGIEIDPKspELKKLIDKIKEL-EKEGYHFEAAEASLELLIKRHFglVKDYFDFDAYRVliakrRDDSLPTSEATVRLSVEGVEEHTASLGNGPISALDRALRKALEEfypnlkELQLIDYKVRIINEsaGTSAKVRVLIESTDGKRKWGTVGVSENVIEASWIALRDSI--VYKLMKDEEE---------------
>UniRef50_Q2RGA1(1-531:533) 2-isopropylmalate synthase n=5 Tax=Clostridia RepID=Q2RGA1_MOOTA   E=1e-136 s/c=0.92 id=29% cov=97%
MAEKILIYDTTLRDGSQGEGISLSVEDKLKIASRLDRLGVDYIEGGWPWANPKDMEFFLRAREViWRQARLVAFGRTRKPGQAAAEDanllAIKRAGVKVATIFGKSWDLHVTAALGTTLAENLAMIGDSVAFLVDQGLEVIYDAEhffDGFKANPDYALETLKAAAKAGASWIVLCDTNGGCLPWEIEEAVARVRQEI----QVPVGIHAHNDGDLAVANTLAAVTAGCRQVQGTINGFGERCGNADLCSVMPNLELKMGYQCLPPG-QLAFLTEVSRYVSEIANVVPAGNQPFVGYSAFAHKGGIHVSAVLKAPDTYEHIRPQQVG-NERRVLMSDQAGASNLRCKAEEMGLELNPERERGIIEGIKELERQGYQFEGADASLELFLRKTTgEYRQQFEVEYVKAlvekRAGQEAISEAIVKLRVGDQVVHTAAEGNGPVNAMDNALRKALEevfpaiRHMRLTDYKVRVLDEkdATSARVRVLIESRDGSNSWNTVGVSTNIIEASWEALLDSMEyaLLKQQQELNKRAAAPCE---------
>UniRef50_D2RVT7(13-500:508) Pyruvate carboxyltransferase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT7_9EURY  E=1e-130 s/c=0.96 id=35% cov=93%
--RTVRLLDTTLRDGEQAPGVSLTPDEKVDIARSLEQAGVSVIEAGSACTGAGERQAISRVTDLELDARVTSFCRGMESDIDLALD----CDVDGVHIVVPASDRHIEDKVGTSHEDNLEKTAELVAYAKDHDLWVEVIGEDGSRADLDYLEELMATAVDAGADRICFADTVGHTGPERTAEAVGRLADVGP------VSAHTHDDLGLGVANALAAVSAGADLVHCTVNGLGERAGNVALEEVAIAL---SHVYDVET-LELTELYDLAQTVSRATGIQLPPNKAVIGENAFTHESGIHTDGTLKDDKMYEPYAPETVGR-ERRLALGKHTGRAGVTATLEEHGVEADSDEVAEIATRVTELGDRGRRVTDADLLAIAEDVTGDDRERVVELLDLNATSG-GAVPTASVRLEVDGEERVASGTGSGPVDAAVSAVREALGsmADAELDSYHVDAVTGGTDAVVTVEVTMMRNDRSVTVARSEADITRASVEAMVDALDRLLAADQ-------------------
>UniRef50_Q9FN52(85-484:503) Methylthioalkylmalate synthase 3, chloroplastic n=19 Tax=Brassicaceae RepID=MAM3_ARATH  E=1e-123 s/c=1.11 id=44% cov=73%
----VRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSEEEFEAIKTIAKTVGNevdeetgyvPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSEIHMKYKLKKTKEEVIEMAVNSVKYAKSLGFkDIQFGCEDGGRTEKDFICKILGESIKAGATTVGFADTVGINMPQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGARQVEVTINGIGERSGNAPLEEVVMALKCRGEslMDGVYTKIDSRQIMATSKMVQEHTGMYVQPHKPIVGDNCFVHESGIHQDGILKNRSTYEILSPEDVGIVKSEnsgIVLGKLSGRHAVKDRLKELGYEISDEKFNDIFSRYRELTKDKKRITDADLKALVVNGAE-------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4A2P3(2-535:542) 2-isopropylmalate synthase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A4A2P3_9PLAN  E=1e-120 s/c=0.81 id=27% cov=97%
--RKIEIYDTTLRDGAQGEGVSFSLQDKLSITERLDEIGVDFVEGGYPLSNEKDAEYFRRVQDLnLKHTKVCAFGMTRRKGINAAddpgMQALVSSGAPVVTIVGKTHDFHVTDVLRVTLEENLAMIADSVAYIVGAGREVIYDAEHFFDgwkANPEYAAETIRAAAKAGARMVVMCDTNGGSLPEEIAEYAAKAIAALTEF-NVPVGIHTHNDGDLAVANSLAAVDAGAVQVQGTINGFGERCGNADLISVIANLGLKRKGYEVIGGAGYQHLTELSRFVYDTANVNRRNNQAFVGQSAFAHKGGMHVHAINRAASSYEHIDPQSVG-NERRVLVSELSGRSNIVALTTKHNLQDDRELMDKILAEVVA-KENQGFQFEAAEASFDLLVKRVAgvfephfeiLKYHVEVEDLVEHKMVDLVTEATVKVSVDGEIRYEVGEGDGPVQALDVALRKSLNgcfptlEEMHLVDYKVRVVNqeAGTAARIRVTIESADENDVWGTIGVSENIIQASWNALVDAIEyKLYKDEQRGKLPARAS----------
>UniRef50_B3PEP5(147-668:673) 2-isopropylmalate synthase n=90 Tax=Bacteria RepID=B3PEP5_CELJU   E=1e-119 s/c=0.83 id=25% cov=93%
-----IWMSTDLRDGNQALIDPMSVQTKLRMFKELVAIGFKEIEIGFPSASEIDYNFTRMLIEEnliPDDVTIEVLVQARYDLIEKTVQSLRGARRAILHMYNPLAPAFRKIVYNTDKEGVKKIALQGTQWCKELTAqapevdwTFQYSPEVFSSTEIEFVKEVCDAVVEIWNPspqkkiILNLPATVEMNTPNTYADQIEWIHRNIHRRDSIVISVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQ----GVHPGLDFSDIDKVRKLHEECTQLPVHPRHPYAGELVFTAFSGSHQDAIKKGFAvqkkdtlwevPYLPIDPADLNRSYdAVVRVNAQSGKGGVSFLLqQEAGLQLPRRLQIEFSSVVQKVSDSTGKEVKASDIARIFNEEYfaVNSPITYQSSKFTEQDDTHQVDI-VIHAQHQNKTVEISGSGNGPIDAAAHAISQFIDTEVNVIDYHEHSVGEGSDVVAVTYVEIKVkNGKPVYGVGQDRNIITSAVKALINGVNR-------------------------
>UniRef50_B2UP78(1-543:544) 2-isopropylmalate synthase/homocitrate synthase family protein n=2 Tax=Bacteria RepID=B2UP78_AKKM8  E=1e-116 s/c=0.78 id=28% cov=96%
MSTKIFLYDTTLRDGAQSEDVNLSATDKVRIARQLDYLGMDYIEGGWPGANPVETEFFNAMRGVGlRNAKLAAFGSTHHpshtPETDPTLTALISSGARVAAVFGKSCPRHVEVALGISRERNLEIIGNSISFLKKNMEEAFFDAEhffDGFKRDQEYALAVLRTAWEHGADCLVLCDTNGGTMPEEISSIIRTVRERLP---HALLGIHAHNDCELAVANSLAAVNSGAIQVQGTVNGIGERCGNANLCSVIPNLQVKMKGFSCLSGASLTRLKSTAAFVSEVSNLAPFRRQPFVGNAAFAHKGGVHVSAIMKEAALYEHIDPSLVG-NAQRVLMTEQGGRSNILSLSRTLGFELEkgDPLLDVLSAAVKKNAalgyDYVAAPASAELLFLRHMPDNALKPYFNILRTVVLTSrhemDPDMMVEASLKLDVHGNVEHTAAGGFGPVHALDRALRRALTRwypeleQMHLIDYKVRVLSPtrtnipeaedenGTGSNVRVLIESSDGVATWTTVGVSYNIIEASLEALADAVTyKLYKTEQ-------------------
>UniRef50_Q04TA5(1-516:516) 2-isopropylmalate/homocitrate synthase n=14 Tax=Bacteria RepID=Q04TA5_LEPBJ  E=1e-115 s/c=0.81 id=27% cov=94%
---RLEILDVTLRDGEQTRGVSFSTSEKLNIAKfLLQKLNVDRVEIASARVSKGELETVQKIIEWAETEQLTERIEILGfVDGNKTVDWIKDSGARVLNLLTKGSLHHLEKQLNKTPKEFFADVSIVIEYAIKNGLKINVYLEDWSngfRNSPDYVEALVKHLSKERIERIFLPDTLGVLSPEETFQGVDSLVQKYPNLH---FEFHGHNDYDLSVANSLQAIRAGVKGLHASMNGLGERAGNTPLEALVTTIHDKSQA---KTNINELAITEASRLVEVFSGKRISANRPIVGEDVFTQTAGVHADGDKKGNLYANPILPERFGR-KRSYALGKLSGKASISENVKQLGMVLSDIVLQKVLERVIELGDQNKLVTPEDLPFIIADVSGRTGEKVLTIKSCNIHSGIGVRPHAQIELEYQGKVHKEISEGDGGYDAFMNALTKITNRLgisiPKLIDYEVRIPPGGkTDALVETMITWNksldlEEDQTFKTMGVHPDQTIAAVHATEKMLNQIL-----------------------
>UniRef50_C9RN88(2-512:535) 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RN88_FIBSS  E=1e-114 s/c=0.81 id=29% cov=93%
---KVLLYDTTLRDGNQDRKISLSLADKVQIARILDHFGFDYIEGGWPNpSNPTDEEFFKLIKDvKLKHAKIAAFGSTRRPGIlpenDPLLQALIKSEAPVKTIFGKSWDLHVTDVIRTTLEENLDMIESSVAYLKEHSEEVIYDAEhffDGYKANPEYALETLKAAELGHADCIVLCDTNGGTMPWEIEEIVKKVQTRI----STPLGIHVHNDSGLAVANSIYAVKAGCVMVQGVVNGYGERCGNANLTTIAADLKFKMD-RDFAAAKKLSHLRQLSGNIDQIVNLPSDVHAPYVGDAAFAHKGGAHIDGVMKVSRSFEHIDPHSVG-NDRVFVTSDQAGGSLVVEKLKaiKPGIDKKDPVVASLLKEIKE-RENAGWHFDSAEASFKLLVYRHlgMVKEPFKVLNYRVIEDKTPqgvsVSQATVKLQVGDKISHQVSEGDGPVNALDAALRKALLPffpcmgSVRLDDFKVRVLGSnvASDATVRVWTTFGDEHGYWNMVGVSSNIIEACWTAFVDGL---------------------------
>UniRef50_B1MVR2(7-392:398) 2-isopropylmalate synthase n=1 Tax=Leuconostoc citreum KM20 RepID=B1MVR2_LEUCK  E=1e-112 s/c=1.06 id=42% cov=71%
MTNQITFYDPTMRDGEQTIGVNFTIDEKIKLAQALEKYGVSAIEAGFPAASKKDFDAVVEISKVVHTAKVVGLARLVRQDIDAVVAATQQAKHPMIHVFIATSPVHRTYKLHMSPSEIIEKVISDIRYTKTMMSEIIFSPEDATRTEPEFLARVIQAAIESGATMINIPDTVGYATPYEYGELFEYLREHVRDFDQVTWATHTHNDLGMANANALAGIMHGATEIQGTINGIGERAGNVDIIEAAAAIYVRRQTFAKQTAIILEQSKHISDIVAQATHMPVAKNKPIMGRNAFAHESGIHQDGYLKNPETYEILRPEMVG-TQASLPLGKLSGSHAVMNQLLSLGYHISRQDMVTILPIFKRIAEKTSTVSD-------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7GT76(68-638:638) 2-isopropylmalate synthase n=19 Tax=Bifidobacterium RepID=B7GT76_BIFLI  E=1e-111 s/c=0.71 id=25% cov=93%
-----RWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRMLIEReliPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLATDAAELCKDLeneakgiDLYYEYSPESFTGTEPEYAVEVCNAVIGVikptpeHPMIINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCLLGNGERTGNVDL----VTLGLNWLTQGIDPQLDLSNVPEIRKTVEYCNQIKISERHPYAGNFVFTAFSGSHQDAIKKGLEarqvaaeragadldsfvwlvPYLPIDPKDIGRTyEAIIRVNSQSGKGGMAYLLKTnHNLDLPKRLQIEFDKIVQNYADtTKKEVKDGDIWRLFKDEYLPveqsgmtaagvvvgdthdaslEPWGRLKLLKVAVSSGEDGSDTVlkarlldrGVNVGDDEPVeREASGIGNGPIAAFLNAISNF-GVEASIMDYVEHTMSVGTDAMAASYVECQigeaDDAQIVWGVGIDSSITTSALKAIISAINR-------------------------
>UniRef50_A6C4F8(30-394:406) 2-isopropylmalate synthase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C4F8_9PLAN  E=1e-110 s/c=1.10 id=40% cov=69%
----VLFSDTTLRDGEQMPGATLDPIEKLQIAKALEAAGVHSLDAGFPASSQADIDAIQSMVGVIKKPVLTALCRTLPGDVDAADEALAGNPphKRGVSLFCGTSPLHRQFKLEKSKSEVLKLIVDSIQYAAEKFDIVAFSPEDASRTEVDFLCEVYREAIAAGATTIGFPDTVGILTPWKAQDFICRIQDEVPGIENVLLAVHFHNDLGLAVANTLACIDAGANVVQCTVNGIGERAGNAALEEVAMALHLHQEEYQRPHQLDVSQLAPLCKLVAELTGIALSPMKPVAGSNIFATEAGIHQDGLLKNPDTYLPYRPETVGETGIRLVLGRHSGRKAILHRLHELGKEPNEQVVQRVLQAIKEL----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6LPH9(9-388:389) Homocitrate synthase n=10 Tax=Clostridia RepID=A6LPH9_CLOB8   E=1e-101 s/c=0.98 id=35% cov=66%
-NKKVSIVDTTLRDGEQTAGVVFANEEKIVIAEMLSDLGVDQLEVGIPTMGGDEKKAIKEIVKRNLKPSIMAWNRAVVSDIEQSID----CGVDAVAISISVSDIHIQHKLKTSREWVLESMVKSVEFAKKNGLYVSVNGEDASRADKDFLVEYINAAKQAGADRFRYCDTVGIMEPFKIRDDIKYIYDK----TGFDIEMHTHDDFGMATANAVAGIKGGASHVGVTVNGLGERAGNAALEEVIMALMLVYGYNG--DGINTQMFREVSQYVSRASGRELPIWKAIVGTNMFAHESGIHADGAIKDPKNYEAFDPDIVGL-ERQIVIGKHSGRASIINKFREYNRELTEDEAKGILE---------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0TAQ1(1-369:380) Homocitrate synthase, nifv n=4 Tax=Clostridiales RepID=B0TAQ1_HELMI   E=4e-97 s/c=0.97 id=31% cov=67%
MRQRVWLMDTTLRDGEQTPGVAFCPQEKALLARRLAEAGVHEIETGVPAMGEDEQETIARIVKLNLPTRVTTWNRAVISD----LEASLNCGVRSVAICLPSSDQQITQKLRQSRQWVLDQMGACVRRAKAEGLYVVIGLEDASRADPQFLIQLGLEAERLKVNRLRISDTLGILDPIRTFNLFDRLTSSL----SIPLEIHAHNDLGMATANTVSAIQAGAKAASVTVCGLGERAGNAPLEEVALALR---QCCAADTRINLALLPALCRLVSWSTRRPIPFSKPVVGRDAFTHASSIHVDGLNKDRSNYEAYPPEYVGR-RHRIAFGKYSGRKLLAELLKAQGHDLDQEEMTQLLLNVRQL----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8I2I3(16-365:388) Pyruvate carboxyltransferase n=1 Tax=Clostridium cellulolyticum H10 RepID=B8I2I3_CLOCE  E=3e-96 s/c=1.01 id=31% cov=65%
---KFFFCDTTLRDGEQVSGIRYTPEQKVEIAQMLDKAGIESIDAGFAATSEEERLSIRKICDLGLKMRIMSMCRVIREDIDFA----SSCGVEGVILFIPGSDIHLKAKFGEDipavRKNIVQKAMDAIKYAKDKGLFVEFGVEDSTRTDFNVLLEILSQAEQEGADILGTTDTIGYLTPERTYNFIKKLVRNL----KLPIGVHCHNDMGLATANTIAGLLAGGGYCSPTVNGMGERAGNASLEEVIMILKV---LYNQDLKYDTKILGELSKTVEKYSGISMDIFKPIVGQNAYSHESGIHVHGMLKDINTYELFDPQLVGHSR-KYEMGKHAGKHTIQHILKTNGFELSEEEVEDF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1SID8(2-356:376) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SID8_9BACT  E=2e-93 s/c=0.97 id=33% cov=68%
-----IIDDTTLRDGEQTPGVAFSRKEKLTIVKHLDAIGVQEIEAGIPVMGLAESRMFESIMELGLDARIIAWNRALIGDVQASI----AAGANSIEISLPMSDVQINTKLNKTRGWILDQVKSVLDFCANHDLYISVGGEDASRADFDFLAEYIRTIEAHGADRFRFCDTVGILDPFKTYELTAKIR----EITSMDIEIHTHNDFGMATANALAAVRAGATHVNTTVIGLGERAGNAPLEEIIMA---SRHVYGMDDAFDTKTMRSLSEYVAQAAGRNLDPQRPVIGEFMFTHESGIHTDGVLKNPKNYEAFDPAELNMQRN-LVFGNQSGLAVLKYILEQEGIVLESYQLTGLLHEAKKLARKNKAVLN-------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P54610(22-375:401) Homocitrate synthase n=6 Tax=Frankia RepID=NIFV_FRASP   E=5e-90 s/c=0.94 id=32% cov=67%
----VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILATDPKAEIVGWCRADHRDV----EAAASCGLVTAHLTIPVSDLHLKSKLERDRAWARRRVRDCVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLDPVSAYDRLGRLVRAVPG----PWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEVAMALR---HLLKLPIDLDTTSFRTLAQLV---VGWPLPAgKKAVVGESVFAHESGIHVHGILRHPATYEPFDPEVGGR--RRLTVGKHSGRASLRHALEQCGITAEESELEPLVEQVRLAATRHKRGLD-------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q12122(35-432:440) Homocitrate synthase, mitochondrial n=109 Tax=cellular organisms RepID=HOSM_YEAST  E=2e-88 s/c=0.83 id=28% cov=67%
-----QLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVET----GVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDY-VRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAKIKKLGD--------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JSY7(28-390:403) Putative uncharacterized protein n=2 Tax=Bacteria RepID=A3JSY7_9RHOB  E=4e-86 s/c=0.88 id=28% cov=67%
LPAKVEIHDATLRDGEQTPGVVFSIDDKIAIASKLDELGVDRIEAGMPAVSPQDATAITEISKLGLKSKIYTFARAMKADIDMALQ----CGADGVIIEVPIGYPKLKTQFGWTWEDVVKKSAPVINYAKENGLHAVFFPYDTTRARRSDLENMCKAIMDqSPPDAIGLVDTMGCATPEAIKYMVRWLTK----MTELPVEIHTHNDFGMGVATELAAVTAGAQCVHSCANGLGERTGNAALEELMMGLHL---LYGYDTQYKLGKIPELGALIAERSNISIARNKPVLGHGNFIRESGIGIDYVMNDPLVMFGTHPSLTG-KVGEVVLGKKSGKASIIYKMGELGMgVLEDDKIAMILEEVK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5QA64(6-374:390) 2-isopropylmalate synthase n=1 Tax=Staphylococcus epidermidis BCM-HMP0060 RepID=C5QA64_STAEP  E=9e-86 s/c=0.87 id=32% cov=65%
--RKITFLDTTLRDGEQAPGNSLKHGEKLELALMLEKAGIETIETGFPASSKEDFISTQKISKILKTSNFATFSRTKLEDIDLSIQAGGTSEKHILMLVATGSDLHLEKKRKMSRQDGIEEIKKSVVYAREKGIKnVAVGIEDASRADSKYVEELINVAVQSGANQIILADTTGYAMPNDIYDLVKLSKRCISK--SIKLSVHCHNDLGLAVINSYYAILAGADEIQGTIGGIGERAGNTSIEQVLALIHYKGKNKKIYSDVNKKNLYPIYEKLSEYIDLEENRTLPIFGKYVFSTAAGIHQQGILNDPKTYEFVLPEDWGRTR-EFYIDKHSGKSILKDVVEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LNR8(12-366:429) Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNR8_HALO1  E=4e-85 s/c=0.90 id=31% cov=67%
----VEIIDCTLRDGEQAPGVWLTVQEKLALAKLLSQAGVDVLDAGFPASSPADMEAMQEMVAAGLRARIAATARPLARDIVAA----EMANAHEVFMFLPTSALRMEQTLGITRDQAISLFCSGAEEVCSRGMTLNLVFEDATRSRPEMLTEIVRQVhAQADVRRVILADTVGCAIPAAMEALTRTVRSEID--ADIVVTPHCHNDFGLAVANTLAAVSGGAGAVTCTVNGIGERAGNADLAETVAGLSL---LLQREHGVDPHQLVALQEAVEIATGIHQSPTKPVTGINVFRHESGIHVDGMLKDPRSYEFLPASWVGR-RSEYILGKHSGTSLIRRLAHMAGLDCDEHTASLLLAEVK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q07179(5-381:382) Homocitrate synthase n=3 Tax=Rhodobacter RepID=NIFV_RHOCA   E=5e-83 s/c=0.82 id=33% cov=64%
--------DTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVVAEIAHATPVVWCRLRMHDLDMA----QKTGVKRVHFAVPTSTAQLEGKLRVDRDWILRETAALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDPLGAFRLVAELSARI----SLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAACEEVGAAL----EAGGIDTGLDLCALPELSAVVAKASGRAFRAQKPITGDDwLFAHESGIHVDAILKRADTYEdpRCAPARFGR-ERQIVIGKHSGSAGLRAALLEAGLPADDAVLDRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IYY1(17-385:389) Homocitrate synthase n=1 Tax=Deinococcus geothermalis DSM 11300 RepID=Q1IYY1_DEIGD  E=2e-79 s/c=0.81 id=25% cov=69%
------IIDSTLREGEQFARGNFKTGDKIEIARLLDAFGAEFLEVTTPMVGAQTQADIRRLTSLGLNAKILTHVRCHLEDVQRAVDL----GVDGLDLLFGTSSFLREFSHGKSIAQIIDTASEVIGWIKQNhpDLEIRFSAEDTFRSEEADLMAVYRAVSDLGVHRVGLADTVGVATPRQVYTLVREVRKVIH--AECGIEFHGHNDTGCAVSNAYEAIEAGATHIDTTILGIGERNGITPLGGFLARMFT-FDPQGLIDKYNLELLPELDRLIARLVDLPIPWNNYLTGEFAYNHKAGMHLKAIYLNPGAYEAIPPSVFGVGRRIQAASKVTGKHAIAHKARELGLHYGEDALRRVTDHIKALAE-EGELDDAHLE---------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7LNR6(2-351:373) Pyruvate carboxyltransferase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LNR6_DESBD  E=4e-77 s/c=0.83 id=28% cov=67%
--------DTTLREGAQMFGTSIPQEAKIRIAGRIADMGVEEIEIGWMGQ-EGLDEVVKALRGRGVTCDLSVWSPCRTVDVYRAA----GLSIDTINIGLPVSDLHIAERLRTDRDGLTRMLRETVGLAHSCGIrRISIGLEDVTRADQDFALSMARMAKELGAARIRLADTLGVMTPTRIAELVRFFAQSV----DMEIAIHCHNDFGMATANAITALEAGAHWADVSVLGIGERSGISALEEVAGHLRLVQGYDIYDMNL----VRALCDLVAEYARIPVARNRPMSGGDIFAAESGLHVDGILKNPALFEPYDPAQTGA-KRILALGAKAGRGAVRTMLRQVGLKGPLHSIGNMVDTIRERAHRTGR----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1MYB9(69-726:757) 2-isopropylmalate synthase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MYB9_9CHLO  E=2e-73 s/c=0.42 id=27% cov=94%
-PRRVDIYDTTLRDGSQqarptnpppppprtservhivsvvasirtpgiesesrasltermtdgltrspptpprarartlQVGISLTCDDKLEVASHLVSLGVSHIEGGYPGSNPKDVEFFNRWdssglakAAEARGTKLCAFGMTRRKGVEAkddeGLNALVRCVAPCACIVAKAWDEQCERVLGVSGEENLAMITDSVSYLVERGKEVLVDCEHFYDghaANGEFAMRCAVAAAEAGATHVVLCDTNGGTLPWVVEEKTRAVVDALKKSsnPSCRVGVHTHNDTALAVANSLAGVRGGASMVQGCVNGYGERTGNADVLVVAANLELKMGVTALPPGGVAKL-TATAAAVAKACKQPLEARQPYVGSSAFAHKGGLHVAALAKMPSSYNHVVPGTVG-NAARSVVSELSGRGNVLSAAVAAGREVSKDTAGIVLAQIKEL-ESKGFVLEDagASVDILFQRAAAGYRAPFNVLEFNVSASNNafggvvtaegmedakdldfvdddfapddededaawratslrresgykrgtvsvnqvvvkvelleydddddatadSKPSAAKAIRSSRRRtKLCVAEGNGPVNALANALQLALNErfpqlkRIHLVDYQVDLLSseGTSAAVTRVTMDFvdRGGGGTWRTVGAHASIIEASFRALVDGM---------------------------
>UniRef50_Q7X1M2(20-304:304) Homocitrate synthase (Fragment) n=1 Tax=Leptospirillum ferrooxidans RepID=Q7X1M2_9BACT  E=4e-65 s/c=0.88 id=31% cov=54%
--------DTTIRDGGQSPGVFFDRPTKMVIVTTLSRIGVQEIEVGTPCLGDHEIEDLRALLSLPVPVELFPWLRPLEAD----FESALGLGFKRVHVSFPTSDAHRASVQNMGRPDIVERVRKTVLRMTGEGCRVSIGLEDASRAPMDFLKEFIAAVRESGGIRVRYCDTVGKHHPAEIIERISELSK-----EGLPIEIHCHNDLGMATANTVSACHSGARYLSTTVTGVGERAGNAAMEEVAFALACERGDpsLPESSAIDLPGLAHISRWLYGAIRRTLSPYRPIVGSRIFHHSSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1NS12(4-324:363) Pyruvate carboxyltransferase n=2 Tax=delta proteobacterium MLMS-1 RepID=Q1NS12_9DELT  E=7e-62 s/c=0.75 id=30% cov=61%
--------DSTLREGLQTVGLDLSQERQVELAGELAAMGIEELEVG-PLRPDDDEvgQLLNRCRHQAGVARLAIWCRCRAADIERALAW----QPEVLALSIPISRLQMQVKLQRDEAAVKELVTAALRRTRGRVGYLSLGLEDATRAEPRFLAEMVRLAKREGAHRIRLADTVGIATPAEISELVRLVRD--CGGRRLAIGVHTHNDFGMAGANAIAALAAGADWADVTLLGLGERAGLARLEEVAAYLALRRQR-----PYQLTGLPQLCARLAGFCGQPIASRQPVVGSDIFACETGLHLAALQQDPATYEPFEPALVG-NRRQLLYGTKTGRQALA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LGL9(29-399:424) 2-isopropylmalate synthase n=3 Tax=Nannocystineae RepID=D0LGL9_HALO1  E=8e-62 s/c=0.65 id=23% cov=68%
--RQVSFLCETLRDGIQSPSvVDPDIGDKLRLVELADSLGIHHIDIGLPGAGNRAVEDCTTIATFIRDNKLrirpACAARTHKNDVGAIVDISQAVGIEIeVLTFIGSSPI-RQYAESWDLERMLNFSSEAIDLAARHNLPVTFVTEDTTRSRPEVLDQMFRNAIEHGANRLCLCDTVGHSTPDGIHNLIRFTRNLLEamGRPDVGIDWHGHNDRGLGVVNTIFAIEYGASRVHGTAMGLGERVGNAALDQV----LLNLKLLGELPEQDLSKLLLWCKVAAKACHVAIPPQYPLAGSDAFRTATGVHAAAIIKAEKKghewladriYSGVPAGMFGR-EQEIEIGHYSGESNVIYWLRKRGFDPTPELVRTVLSAAKR-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A0YSY8(7-270:271) 2-isopropylmalate synthase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YSY8_9CYAN  E=4e-60 s/c=0.89 id=37% cov=51%
----ILIFDTTLRDGELTPGVHFSTPDKVQIAQQLEEIGVDTIEIGYPGRYAKDIDEIIAVSQVIKGSTLCALAGSQETEINKAAKSLEKAEKSSINIYTLVNLTSSSKTLDKN--SILSTLKKQISQAKNYCNIVQWTAFDATRGDINFLCEAVQTAIESGAKIISIPDSLGVALPEDFYNLLQKLYQNIPQLQHVTVSVHCHNDLGKAVENSLVGLEVGVRQIECAVNGLGARKGNANLTKVVNLIQSHHSYY---TTINHNLIPKISELI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1PZE3(2-251:264) 2-isopropylmalate synthase (Fragment) n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PZE3_9BACT  E=1e-54 s/c=0.87 id=26% cov=46%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRTNINESQLNMISRVVEDHSGIAVAPNQPIVGENVFTQVAGVHADGDNKDNLYCNELKPERFGRKRA-YALGKNSGKANIEKNLEELGMELTPEQTRMVTQRITELGDRKEFVTQADLPFIVsDVLKHNTQEDCVKLLSYMVSTSYGLKPIASIKVEINGKDYMGESTGDGQYDAFVKALRKIYKENlnrtfPRLANYTVSIPPGGhTDALVQTVITWhEESGRMIRTQGLDVDQTESAIKATFKMLN--------------------------
>UniRef50_C0WB33(2-286:315) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C0WB33_9FIRM   E=7e-54 s/c=0.75 id=24% cov=51%
LPKKIRICEVGLRDGLQNEKRMFTTEEKLELLDGMGKAGFSVIEVGsfmSPKAVPQMAntDEVYEKLEKVPGVEYRALIANLRG-----VERAIACGCKKVKLNVSASRAHNLANLNRTPEESVARFGDCVTCAKEAGLEISGSISMAFGSPWDKeipigaVASIVEAYMAVGINEISLSDASGMAFPPQVQEICAYMKKHYPKN---MWWLHFHNTRGLGMANILAGMQSGFTQFDSSFAGVGgcpfvpGAAGNVATEDVL----NLCEESGIDTGIDFDKALEVSRRVAQL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0GGI7(7-296:307) Pyruvate carboxyltransferase n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGI7_9FIRM  E=1e-53 s/c=0.73 id=24% cov=50%
----VLIREVGLRDGLQNEKQFVATEDKIRLARALTAAGLREIEITsfvSPKAVPQMRDAkeIVAALGQPEGVTYSALVVNRRG-----AEDAIASGVKELQYVVSCSETHSQKNVRMSVDEALQQAAIISDLAKENGLTIRtalsatFGCPFEGKTSYDRVYDLLEKLFSLGVERVSLSDTAGLGNPRQVAQLCQGIVARFPEDR---FSLHLHDTRGLGLACTLAGVWAGIRVIESSIGGLGGcpfvpnATGNIATEDVVYMM----EEMGISTGLDWQQLMNAAMMAEKILG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O34873(4-291:299) Hydroxymethylglutaryl-CoA lyase yngG n=13 Tax=Bacteria RepID=HMGCL_BACSU  E=1e-52 s/c=0.73 id=21% cov=52%
-PKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSfvhPKWIPALRDAidVAKGIDREKGVTYAALVPN-----QRGLENALEGGINEACVFMSASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRaylstvFGCPYEKDVPIEQVIRLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQ---IALHFHDTRGTALANMVTALQMGITVFDGSAGGLGgcpyapGSSGNAATEDIVYML----EQMDIKTNVKLEKLLSAAKWIEEKMGKPLPSR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6CMV0(16-299:311) Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillus RepID=A6CMV0_9BACI   E=2e-51 s/c=0.73 id=22% cov=50%
LPKKVTMIEVGPRDGLQNEKNFVPTDIKIQFIRALKEAGLKEMELTsfvSPKWVPQMKDA-SEIVESCLNSERDIVLAPNRKGVDRVLET----KGKAVAVFVGVSNSFNKKNINKTTAESLEELKPIVGELKEKGYFVRacistsFYCPYEGKIPPQETLQLCREFVDMGVDELSVADTIGMANPKESFELFSLLKKTLPE---VLMTAHFHDTRKMALANILASLQAGVDRFDTSAGGLGgcpfapGASGNAATEDVVFMLH----QMGIETGVDLDSLTAAVNLVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6PWR8(5-293:303) Pyruvate carboxyltransferase n=1 Tax=Clostridium carboxidivorans P7 RepID=C6PWR8_9CLOT  E=2e-47 s/c=0.67 id=20% cov=50%
--DRIKVVEVGPRDGLQNLKNWIPTEVKIKLIKDLIDAGIKEMEMTSfvhPKAIPqmKDAEAVtKAVIDELNEKEIRTF--ALVPNLVGAKKA-YGCGLREITYVISASEKHNLANINRTVQQSLEGLADIRAELPDiqirLDVATAFGCPFMGQVGEDLVINLIRSAEKIGINTITLCDTIGIANPKQVYELSQKVSKEF---QNIPVGLHLHDTRGMGIANYLAAIEAGISVFETSIGGLGgcpfapGAAGNTATEDLVNMLN----EIKVETNIDLNALVSISKELEE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1TMW3(10-293:338) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Burkholderia sp. CCGE1002 RepID=D1TMW3_9BURK  E=5e-47 s/c=0.67 id=22% cov=43%
--ESVWINDVVMRDGLQMEPVFVPTSEKVALIDEIGHCGLNRIEAtsfTSAKAIPAlsDAEAVMHEIERVPGVRYAALVLNRRG-----AERALECGVDELNLGVSASETHNLANTRMTRAQAVRALLDITAFCRDRlaigvSIATAFGCPMEGAIDIDSVLDIGNQFVAAGVRGITLCDTTGMANPRQVKAVCGALAARWRGIE---LTLHLHNTRGMGLANVVAGLDAGIRHFDASLGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8MEN7(3-295:306) Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MEN7_ALKOO  E=6e-47 s/c=0.65 id=24% cov=50%
IPKSVEILEVCPRDGFQNVKDFIATEDKIAIVERLIDANFKRIELGsfvSPKAIPQmaDTKEVVAAAKQYavdQDIKFVALVPNARG-----VESAIAAGVDQITYVISASESHNKANVNRTVAESMEQYEALIKEYKgdidfRLGLATTFGCPFGDEVKIERIQEMCKWAFDLGTVEILMADTVGLGNPKKVSEVMRTLVNEFGPEKFV---MHLHDTRGLALANTLAAMQYGITKFESATGGLGgcpfapGASGNAATED----LYYMLSEMGIETNIEIEKVYEAIQLI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6QTB6(1-296:564) 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase n=2 Tax=Trichocomaceae RepID=B6QTB6_PENMQ  E=8e-47 s/c=0.64 id=22% cov=50%
MTRpkvpEVRIVEVGPRDGLQSIKDAVPTETKTELIQRLWRAGLRSIELTSIVSTRKvpqlaDCQEIlnnPAIRSLTEDSEASGLRLPVLTPNLKGLDIALSRGVKEVAVFISATEGFSQANINCSVEQGVEKARAVAQKAIEAGIAVRGYVSCIFVDPYDGptnpssVLRCVQELLQMGCYEVSLGDTTGAGTPAKVATLIRYLEKNGVSLRN--LAGHFHDTYGQAVANVLQAYICGIRVFDASVGGLGgcpfapGAKGNVSTEEVVFM----FQNAGIQTGVNLEELVAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8L5S6(32-322:360) Pyruvate carboxyltransferase n=29 Tax=Bacteria RepID=A8L5S6_FRASN   E=1e-45 s/c=0.64 id=23% cov=50%
LPESVTIYEVGPRDGLQNEASVVDVAVKAEFVRRLAGAGLRAIETTSfvpAAWVPQLADAAELL--ELLGPPPRGARRPVLVPNTRGLERALAAGAGEIAVFGSATETFARRNLNRTVDESLAMFEPVVTAARARGLAVRGYLSMcfgdpwEGAVPPGQVAAIARRLVDLGVDELSLGDTIGVATPGHVEA--LLAELAAAGIGPGTLAVHFHDTYGQALANTLAALRAGVRTVDSSAGGLGGcpyarsATGNLGTEDLVWML----HGLGVGTGVDLGALVRTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9FUN7(106-398:402) Putative 2-isopropylmalate synthase n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FUN7_SORC5  E=3e-45 s/c=0.63 id=26% cov=55%
-ARPVEVLDETLRDGIQGVSiVNPSRARKIELLHAMASVGVDVVNLGMPATGPRQFDDACLLAREIVASRLplglTAAARTLAADVDEVARVAERAGAPImVYAFIGSSPI-RHFVEGWGPDFLARSVDEAGRAAAAAGLPFCLVAEDATRSPPDMLRTLFRAAVDAGAARLCLCDTTGHVTPPGVEALVAFARRELGalGATGIELDWHGHNDRGLGLAAALWAVASGVERVHATALGVGERTGNTCLELLVDNL----GRLGARPPVPRERLVAYCAAASRALAWPVTPDHPIAGAL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4PD12(27-328:353) Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4PD12_USTMA  E=4e-45 s/c=0.61 id=24% cov=50%
----VKIVEVSPRDGLQNEKTIVPTATKIELIRRLAETGVPVIEAGsfvSPKWVPQMGDTPQVVAQMPVHPSISypVLVpnmRGLEALQKLLAEYKDASKRvpptDEIAIFTAASESFCKANTNCTIAESLDRLSDVASRAISSGLKVRGyisvvaGCPYEGKVDAEAVGRVSKALLDMGCYEISLGDTIGAGTPTIVEAALNSSVKH-TNASVHFFAAHCHDTMNTGLANVLHLVRLGVRTVDAAVGGLGgcpyspGATGNIDTESVVFAL----HREGYDTGTDLDKLVD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2S7Y3(8-293:311) Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=D2S7Y3_9ACTO  E=1e-44 s/c=0.64 id=25% cov=50%
-----------MRDGLQLE-APVPLEGKLAMLEALVATGVRRIEVTS-FVSPKavPALADADQLAAELSSFQGVHFSALVANARGATRAV-DAGVAHLEYVVSASDGHSRANAGRSTAEAVAAVGEIAALAHGAGGSLEvvvataWDCPFDGRTPIPRTVDVARAVVTAGADRLCLGDTIGTTTPMRVVQLLDAVRRACPG---VEVGVHFHDTRGTGQANALAAVQAGVTQLDSSVGGLGgcpfapGASGNIATEELVYML----EESGVRTGIDLDAVLAAARVTEQAVGRPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1G528(5-299:319) Pyruvate carboxyltransferase n=2 Tax=Proteobacteria RepID=B1G528_9BURK  E=7e-44 s/c=0.61 id=26% cov=43%
--EKVTVREVGLRDGLQMVRTILSTEQKLEWCRRMVEAGSVEIEVTSfvpPKIVPQFADAVEVARGALD---ITGLHAAALVPNLKGAQRAFEVGLSKVHYVLSASNEHNLKNVRRTTAESVEDFARIVlerdtveRTARRitlgAGVATAFGCTISGRVEESGVLGLVETLLEAGADEITIADTVGYANPRQVKALMREV---LAITRDVPVACHFHDTRGLGLANVVAALDAGVRSFDSSLGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0QDG8(2-264:314) MvaB n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QDG8_DESAH   E=3e-43 s/c=0.68 id=28% cov=44%
------------RDGLQNETALVPAGAKVAFVDALSETGVSEIEVSafvSPRMIPQlrDATAVFQRIRRKKGVIYSALVPNIKG-----FENAIAADVEKIAVFTAASETFNQKNINTTVDGSLDRFRPVVKQAGKLGLPVRGYISTAFWCAFEGkiapgpVVELTQRMMDMGIDEISISDTIGKATPEDVARLLDALLPKVPADR---LAVHFHDTYGRGIANVLKSVSYGIGVVDASTGGLGgcpfapGATGNVSTEAVVAAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q21QR6(2-288:308) Hydroxymethylglutaryl-CoA lyase n=5 Tax=Proteobacteria RepID=Q21QR6_RHOFD  E=7e-43 s/c=0.62 id=27% cov=49%
--EHIFITDVAPRDGLQSQAVTVSTSNKLRLIRALADAGVRSVEATsfvSPKAVPQMADAAEVIAGLRFLESETGLrTSALVPNIK-GLERATAVGAREIAVVISATKTMNLKNINMNLAEAEENCKATLHAARASGLatrayiAVAWECPFEGVTDPDTVVRLAAAMRVAGAGEIVIADTIGAAAPGQVAALLRVLAQSIPLD---MLAVHFHDTRGMGAANAYAALEAGVRRFDASVGGIGgcpfapGAAGNLATEDLVM----LAHQCGFTTGINL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2B3P4(3-288:319) Hydroxymethylglutaryl-CoA lyase n=8 Tax=Bacteria RepID=D2B3P4_STRRD   E=2e-42 s/c=0.62 id=20% cov=52%
-SANVRIVEVGPRDGLQNESVLVGTDAKVAYIEALAAAGLTRIEAVSfvhPRLVPQMADAEQVMARVPRRDGLSYIGLIVNA---RGLDRALQAGVDEVNVTVVATETFSRRNQGMSIAAALDSFGAVAGRARAAGLRVtatigaSFGCPFEGEVPPGHVAEMVRRCADSGADEIALADTIGVGVPADVRRLTGAVR----EVTGLPLRFHFHNTRNTGYANALTAVEEGAAALDASGGGIGGcpfapaATGNIATEDLSYALR----RSGVDTGVDLDRLTAAAAYIGERLGAPPP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q46A99(24-343:351) Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A99_METBF   E=1e-41 s/c=0.54 id=33% cov=33%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNYGMATANTLSALRAGVEYVATAVSGIG-IPGVAAMEEVLMAARHLWKNEQVPNGY---TIAADCENILRRAGIILPGEKAIIGKNVFAHESGIHVDGVIKNPNLYEAIKPEEVGLSRF-LVIGKHSGTASLTQKFRQLDLSLSPQEAATLLDKVRYTAVlQKKPVTDAQLKTL-------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1B8I0(7-273:347) 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacteria RepID=HOA2_RHOOB  E=2e-39 s/c=0.62 id=25% cov=41%
--KKITIVDTTLRDGMSSVSHQFTPQNVADIARGLDRAGVGTIEVAhgiglgassiqYGFAAATDPDYVRAAVDAVENADIAALyvpGIATLAELQKAIDAGIKTVRVAVHCTEA------------------DCGQQPVEWAKEQGLTVMTFLMMSHKLDPEPLAEQAAKLDSYGADVVYVVDSAGAMVPRHAGDRVAALRQAI----SADIGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5YV93(5-264:346) 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocardia farcinica RepID=HOA2_NOCFA  E=2e-39 s/c=0.64 id=25% cov=41%
-TRTVTLVDTTLRDGMSSVSHRFTPNDVAAIAAGLDRAGVRTIEVAhgiglgassiqYGFAAATDPEYVRAAVDAVDHADIAVLyvpGIATLAELRAAVEAGIRTVRVAVHCTEA------------------DCAQQPVEWAKDHGLTVMTFLMMSHKLDPEPLAEQAVKLESYGADVVYVVDSAGAMVPRHAGDRVAALRRAI----SAEIGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001BC2CD2(4-280:306) pyruvate carboxyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2CD2  E=8e-39 s/c=0.59 id=26% cov=43%
-PTSVTILDTTLRDGLQIEDAIVPTDAKVALGEQLIAAGLKEIEVGS-FVNPK---KVPQMADTGE--VLQRLQSHEAEGVDfftlvfnlKGAQRAVDAGAKNIKLVLSASEGHSQANSDAPIAQATQRLLEAATFAKDNGVRfdiataVSFICPFDGITDADHLVEVLRPFVDAGAHGVGVADTIGNANPSLVARNTSAVIEAFPGN---PVNLHLHDTYNFGMANVIAALDLGISNFDAAMGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8H935(8-263:326) Pyruvate carboxyltransferase n=7 Tax=Actinomycetales RepID=B8H935_ARTCA  E=1e-38 s/c=0.64 id=29% cov=42%
MLAKTILRDVTLRDGLQLTGKVLSTERKVETVRELIRLGVPAIELGSMAR----ADLVPTMANTLE--VVQALT---PEELEKCWIWVAtpghvakasAAGARNFQYCLSASDSHNKANIGRTTEESLAALPEAVTYTQSvngqiqLCIATSFTCPFEGYVPEERILSIANDPRAEGTTDIVLCDTLGQAIPTQVAGLINRVREESPARRIV---YHGHDTWGLGVANTLAAIQAGAAMVDGALGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JDD8(8-296:312) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Proteobacteria RepID=A3JDD8_9ALTE  E=2e-37 s/c=0.55 id=23% cov=44%
------------RDGFQSIHELLPTAGKIQCVQALIDSGITRIEIGSFVSSKaipqmADIGNIVAAFSDHTGMRFSALVPNLKG-----ADRALASGIKELVFVVSVSETHNQSNVRQSVDSSLDGLKTIADRLRSEKHSVRLRLDLATCFDCPYEGEIqwqqvdavlgkARNICKGIELEVALCDTTGRATPYQVANHFTRLRER-HDSPSLKWAFHGHDTFGMGVANALFAVQHGATTLDASAAGLGgcpfapGATGNTATEDLIYAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6N5U6(1-266:302) 4-hydroxy-2-oxovalerate aldolase n=2 Tax=Legionella RepID=C6N5U6_9GAMM  E=4e-37 s/c=0.59 id=25% cov=42%
MNKKIQLLDASLRDGGHRTNFHFQDGALEEILPALDRSGIEYIEIGYrngslhpinnlGRAGWCDKEYLLFCRALILNAKMAVMAHPENVNQDDLLE-LKNCGVDLLRICIA--------------KDHFSSAIPVIKIAKQIGLEVSINFIHISYYTNAELDAVIAEASLQQPDIIYFADSNGSLLPSR----INEIYDRYINQYAIPFGFHAHDNIGLAQANALAAMNAGVHFIDASLAGMGKGTGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5KC29(2-260:830) AMP-binding enzyme domain protein n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KC29_9RHOB  E=1e-36 s/c=0.61 id=26% cov=41%
------ILDTTLRDGSYVNNFSFTLDETRFFTRELSRLGLELIEVGHGIglgatekgispAVETDQDYMKAAAlaveesgsQKAKWGMFCIPGIAELNHIDLAHD--HNMGFIRIGVTV----------------EDINLARSFVEKSKKLGLYVCVNFMKSYTSSPQEFSAAVAQAASFGADIAYLVDSAGTMVPADVEDYFRTVRRN----SILPLGFHGHNNLGLANINAYTAYNEGAGIVDVSMQGMGRCTGNTSTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5ZS38(4-265:295) 4-hydroxy-2-oxovalerate aldolase n=5 Tax=Legionella pneumophila RepID=Q5ZS38_LEGPH  E=1e-35 s/c=0.58 id=24% cov=41%
----VSILDASLRDGGHRTNFHFKDDDLKKILLPLDNSGIEYIEIGYrngslhpieniGKAGMCPQDYLLYCQSLIKKAKIAVMVHPHNVNEQDLFE-LKNCGVKLIRICIAKGD--------------LVNAVPLIKLAKNLNFETSVNIIHISYYTESELDSLIEEVSEHEPDMIYFADSNGSLFP----DRINCLYKKYTRQYKVSFGFHAHDNLGLAQANALAAVNAGVHFIDASLAGMGKGTGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9P0G7(5-251:354) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio coralliilyticus ATCC BAA-450 RepID=C9P0G7_9VIBR  E=2e-35 s/c=0.62 id=27% cov=41%
------ILECTLRDGSYEIDFQFSKKNADDIALALDEAGFELIEVGHGV---------------GLGATEKKIGVALESDevyMKSAAESVTNGKWGMFAIPGIATLEHLEMAKNYDMDfirigstiEDFPKSEAFVSSAKSQGMMTCANFMKSYAAKPEDLAQASKLAFEMGVDAVYVVDSAGGMLPNEVKLYVEAI---LAEKSDAVIGFHGHNNLGLGIGNALAAIEAGASIIDTSLQGFGRSAGNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6DPR1(4-174:189) 2-isopropylmalate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DPR1_9BACT  E=3e-35 s/c=0.89 id=27% cov=31%
----VKIFDTTLRDGQQGKGISFTVEDKIKIAKLLDENGVSYIEGGWPGASPKVEAFFKEIKNvELKNAKMVAFGSTRRASNsaedDVFLNKIVQSGAPVACIFGKSWDLHVHEALKISLEENLDVIESSIAFLKKSGLEVFFDAEhffDGYKRNPEYAIKCLQAAEAGGAEVLV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6KI73(54-295:451) Hydroxymethylglutaryl-CoA lyase, putative n=3 Tax=Toxoplasma gondii RepID=B6KI73_TOXGO  E=4e-35 s/c=0.62 id=22% cov=44%
---KVRIVEVSPRDGLQNEEKVLSLDDKITFINMLETAGLSTIEIASfvnPVKVPQMADAAALTRQFCSRSKnIGGLSPTFQVLVAnmRGFEEAAEAGAQEISLFTATTDAFCRANINTTVSESLKKFSVIAREAADRGIKTRGYVSCIFECPyqgkvaPTTVVQVARHLLDMGCYEVSLGDTLGVGTAGPTLNLMEELHRN--NFPMETVAMHLHDTYGQALANILVSiVHGGVRVVDTAVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IRS1(1-273:290) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=Q1IRS1_ACIBL  E=1e-34 s/c=0.55 id=24% cov=43%
MADTVKIIEC-PRDAWQGLKGQIPTELKVKYLQELVSAGFKHIDAvsfVSPRAVPQmaDSEEVLKELDPPDDVEIIGIV-VNEKGADRAIatEAVRTLGFP-----YSFSPTFLKNNQNQTLEENAEVLEKVVEKQRSADMDLVVYISMAFGNPygdlwsVDEVLEGIGILADDGIQQISLADTVGLATPQQIADLCGPIVEKF---DYLEVGVHLHGTHTDAKEKVLAAYDAGIRRFDAALGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5W6H6(16-319:548) Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B5W6H6_SPIMA   E=2e-34 s/c=0.49 id=22% cov=45%
------FLDCTLRDGGYYNAWDFPRHIVIDYLNAMEAAGVDIVELgfrslknqGFKGACAYTTDDFLRSLPLPERLTIGVMVNGAELLGDMPLEQTLE------HLFpetAATSPVRL-VRFACHIHE-FQQVLPASTWLKERGFQVGFNLMQVADRLPQEIETLSQQACNYPLDVLYFADSMGSMNPQHTLEIINRLRTHWQG----ALGIHTHDNMGMALQNTLQALEAGVTWLDATVTGMGRGPGNAKTEYLALELGQRRQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5KHS6(3-154:156) 3-isopropylmalate dehydrogenase n=1 Tax=Campylobacter jejuni subsp. jejuni CG8486 RepID=A5KHS6_CAMJE  E=2e-34 s/c=0.99 id=50% cov=27%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKGQVYDYDLEALMFLSYENEEENEFILEKLSVISGN--IPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKVEER---------------
>UniRef50_C6J6G8(3-267:322) Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J6G8_9BACL  E=2e-34 s/c=0.56 id=25% cov=43%
-ANKCKIVDCTIRDGGLVNNWDFSVEFVQKLYAGLNEAGVDYMEIGY-KNSPKllkgadeagpwrflDDDFLRKVIPQKGTTKLSALvdiGRVDENDILPRSESLL--DLIRVACYIK----------------DVDKALQLVQLFHDRGYETTLNIMALSNVMEHELLEAFEMIKDSVVDVVYIVDSYGSLDYKDMEHLVNKFKTHLPGKR---LGVHTHNNMQLAFSNTLVAAENGVELLDASVYGMGRAAGNCPTELLVTHLK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4F0P9(8-242:352) 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseobacter sp. SK209-2-6 RepID=A4F0P9_9RHOB  E=1e-33 s/c=0.62 id=25% cov=41%
------VLDCTLRDGSYVIDFQFTSADTESIGGALDQAGFPYIEVGHGvgmGASETgnnvaaasDADYMAAAAKSVtsgKWGMFCIPGVANLDHVRLAAD--HGIGFIRVGTDVAQAD----------------SAIPFIELARKLGIEVFANFMKSYVLEPEAFGALAARSYDYGAEMVYLVDSAGGMLPHEVRAYLQAAKSAAPEL---PLGFHGHDNLGLAVANSLVSLEEGAAMVDTSLQGFGRSSGNTATE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q24S97(5-254:547) Putative uncharacterized protein n=1 Tax=Desulfitobacterium hafniense Y51 RepID=Q24S97_DESHY  E=2e-33 s/c=0.58 id=24% cov=42%
--KQFIMLDCTVRDGGYINNWAFPIEIVASMYKASSTAGVEIFEIGFlsedtslPLWRQSPAWAVKQVTQEYQGAQISAILEANTVGMKLGIPEETGIDVLRIAL---------------NKDKVVECIPKMADY-KAQGYTVFVQLMGITGYTDIEILNICKLLDECGyIDYINIGDSYGSLLPERTTEIISMMKRN----TRLKVGLHAHNNMQLGMANVLAAVAAGANIVDGSLYGMGRGGGNVPLE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0YTT0(7-259:681) Pyruvate carboxyltransferase n=1 Tax=Chlorobium ferrooxidans DSM 13031 RepID=Q0YTT0_9CHLB  E=2e-33 s/c=0.58 id=25% cov=44%
---HVDILDTTLRDGSYTIGYQFTADETALIAHGLELSGINYIEVGHGlglgadRAGKgaqavTDLVYMRACSNAIRRARFGFFyIPGIGELSDLKLLADEGGAFVRVGVSL----------------DAIDQACHAIREAKRLGLEVWANIMKIYAYSLKESREGSLRFVEAGADGVYVVDSAGGMLPSEVAEYVSEIRKEFTLAGvSARIGFHGHDNLSLSTACSLSAVGAGCDIVDGSLLGIGRSIGNAATEVLAMVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7MMV3(1-281:634) Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=4 Tax=Coriobacteriaceae RepID=C7MMV3_CRYCD  E=3e-33 s/c=0.52 id=22% cov=38%
---KLQLMDTTIRDGQQSLWATrMPVGDMLPILPAMDKVGYWAIEA-WGGATfdtclrfldENPWERLRQIKAKTPNTRLAMLTRGqnlvgykhySRDIVNRFLKAAQRNGVDVFRVFDALNDIRN--------------VTDSAEAVKEAGGWFE-GAISYTISPVHTLdsyLEYAQQLKELGADSIAIKDMAGMLTPYRTERMVRALNDEI----GLPVHVHCHYVGGMAPANILKAAEAGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1F7A6(1-273:291) HMGL domain protein n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F7A6_ACIC5  E=4e-33 s/c=0.53 id=19% cov=36%
------------RDAWQGLPKTIPAEIKADYLRTLIAAGFRHIDAvsfVSPKAVPQmaDSEQVLDYADPPDDVELIGIV----VNPKGAERAIATNAVATLGYPYSISPEFLRRNQHQSPEEAVDMLEQIGEAAYKAGLDFVVYISMAFGNPYgdpagaDELAAACDLLADSGITQISLADTVGLATPEEVHALTRAALDALPE--GIELGLHLH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8VK70(36-362:408) Putative uncharacterized protein n=2 Tax=Emericella nidulans RepID=C8VK70_EMENI  E=1e-32 s/c=0.44 id=21% cov=44%
---QVHIVEVSPRDGLQNIPEFIPTEIKVALIRRLAGTGLQTIEIAsvvSPKVVPQlaDWRAvlghrvVRRLSQSGGGGPasasesdsesesessqqsessfesetefelelepregfcLPILLPNLKGLSLLLSHSPRP-PIRSICVFISATAPFSHRNINCSVDDGLLRAREVTVAAKKAGIpRVRGYISCIFTdpitrepTDPSAVLHCTRFLLESGADEIALSDTDGSGSPGLTSSLLRYLLEN--GVPVDRLACHFHDTRGRGLENVWAAYEVGVRVFDGSVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q88LY5(4-246:534) Aldolase/synthase, putative n=6 Tax=Proteobacteria RepID=Q88LY5_PSEPK  E=1e-32 s/c=0.59 id=23% cov=44%
-------LDCTLRDGGYYNNWNFSEALIAQYITAMQAAGIQTIELGlrslknssFSGACAYTTDAFLSTLDLPPSMTIGVMVNGSElvgkNAGQQALQLLFPSPA-------SESPVDL-VRIACHVHE-FAEALPAASWLKERGYDVGFNLMQIANCSESEIKALAKLANNYPLDVLYFADSMGSMSPDDAAQIIQWLRSEWQG----ALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGMGRGPGNARTEELAIEIAAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q11V59(4-287:289) Hydroxymethylglutaryl-CoA lyase like protein n=26 Tax=cellular organisms RepID=Q11V59_CYTH3  E=7e-32 s/c=0.50 id=19% cov=47%
------------RDAMQGIIPFIPTEVKAKYINTLLRCGFHSIDFGsfvSPKAIPQMKDTADLLDLLQLDGERAALLSII-ANERGAEQALTYSEIDYLGFPLSLSETFQQKNTNKSIDEAMRTVDAIQHLCIRQHKNLVVYLSMGFGNPygeaysPATVIDFVKQLDQLEITTISLSDTIGSSEPELIKNLFRTLQASYP---HIEFGAHFHSRPETAKRKIQAALDAGCKRIDSTILGIGgcpmakdELVGNINTEVLLEELETRAIPSGIHT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7U935(5-294:540) Possible HMGL-like family protein n=1 Tax=Synechococcus sp. WH 8102 RepID=Q7U935_SYNPX  E=2e-31 s/c=0.48 id=19% cov=43%
------ILDCTLRDGGYYNNWNFSDELIENYVRASLAAKIDVIEIGfrsslnnkFKGACAYSSDLFLENLPFLNGTDIAVMVNgseiCRTDSIPRLLEKLfpKPAISSIVSIV----------RIACHFSE-LSRVLSATRWLADHGYKICINIMQISDRKYADIKEITSMASDCPIDVLYFADSTGSLKPDDISRIVEWFRTGWQR----ELGIHTHNNMGIALQNTLRAYEEGVNWLDSTVSGMGRGPGNAKTEELVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1T1D8(14-225:304) Pyruvate carboxyltransferase n=1 Tax=Burkholderia ambifaria MEX-5 RepID=B1T1D8_9BURK  E=2e-31 s/c=0.66 id=27% cov=38%
----VTLLDCTLRDGGYINDHDFSAPQIDAILTRLIASGVDVIEVGYFRR--RNLERHAATIAHCPHAFLASLARqapvrygvmVPPGDVEAAdLDELADLPVSVVR-------------FTCT-DRNLDKAAALGERAKRLGLTTCGNITRVSECSPAQLAEVTRTLAAAGFDTLYAADSNGALHPTDVTDIVGEMRRHFTG----QLGFHAHDSLHLAVANALAAMSAGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IM73(18-293:520) Conserved carboxylase region n=7 Tax=Bacteria RepID=Q1IM73_ACIBL   E=2e-30 s/c=0.49 id=18% cov=40%
MGRIIEVTDLILRDAHQSLMATrMAMEDMVPACEDLDNAGYWSLEC-WGGAtfdscirflNEDPWERLRQFKKLLPKTKLQMLLRGqnllgyrHYEDsvVERFVAKAAENGMDVFRVFDALNDIR---NLQTS-----------IKAVKKTGKHAQGTI-SYTISPVHTItafVEMAKQLKEMGCDSICIKDMAGLLKPQPAYDLVKGIKEAC--GDDMLVHVHCHATTGVTLVSLMKAVEAGCDMV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5VE99(26-295:516) Pyruvate carboxylase subunit B n=3 Tax=Corynebacterium RepID=C5VE99_9CORY  E=5e-30 s/c=0.50 id=21% cov=40%
-PRKIGVTEVALRDAHQSLFATrMALEDMVAACDDIDKAGFWSVEC-WGGAtfdacirflNEDPWKRLRTFRELMPNSRLQMLLRGqnllgyrHYEDmvVDKFVEKSKENGMDVFRVFDALNDPR-----------NLERAMTAVKKVGGHAqGTICYTVSPLH--DVDGYIKLAGQLLDMGADSIALKDMAALLKPQPAYDIIRGVKDTY--GDDVQINVHCHSTTGVTLVTLMKAIEAGADVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8P007(4-246:465) Oxaloacetate decarboxylase, alpha subunit n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P007_ERYRH  E=5e-30 s/c=0.55 id=21% cov=40%
----IKINDVTVRDGNQSlLATRMEHEDILKILAEMDQVGLNAIEVWGGATFDGALRFFKRspwqnlrdMKRVAPNTPFSMLLRGQnivgyhhydNDTLERFIRLSLENGIDIIRVFDALND--------------IENVKNAIYFIKKHGGHCQ-GAISYTVSPvhnIDYYVTYAKQLVEAGSDSICIKDMAGILLPDVTFELVKRLKEEL----DVPINLHSHATTGLSSLVFEQAMKAGVDIVDGCI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5SI54(1-281:286) Hydroxymethylglutaryl-CoA lyase like protein n=5 Tax=Thermaceae RepID=Q5SI54_THET8  E=2e-29 s/c=0.47 id=20% cov=46%
------------RDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTS-FVSPKwvpqmqDAEEVLKALPPPNGRTYLAIV-ANEKGLERALAAPN---LTHVGYPFSLSETFQQRNTNRSIEASWPLVGAMVERTEGRLGLV-VYLSMAFGNPygdpwsVEAVLEALARLKEMGVREIALADTYGVAEPERIHEV---LKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGgcpfagdELVGNLPTEVVLPHLEKR----GLATGVDLSRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9RJA2(4-246:313) Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJA2_FIBSS  E=3e-29 s/c=0.54 id=21% cov=43%
--ETIKVLDCTIRDGGLVNKHDFSLEFVRRLYTLLTAAGVDYMEMGYKNSpelfDPKEYGPWKFCDDDLLWK--------VKDGIDSKMKMAVMADVGRVNMdavkPASESPYQMFRV--ASYVKNIDKGISMVNAFHDMGYETTLNIMAVSRDRGPELDEALHQVnEECKADVLYLVDSFGAF----YQEDIDKELARYKGIvKNKKFGFHGHNNQQLAFSNTIQAIINHVDYLDGSVSGMGRGAGNC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0IC26(1-252:355) 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Grimontia hollisae CIP 101886 RepID=D0IC26_VIBHO  E=3e-29 s/c=0.52 id=25% cov=41%
------ILECTLRDGSYEIDFQFSKKQTSDICKALDTAGFELIEVGHGvglGASEKnigvaletDEVYMEAAANNVKNGKWGMFAIP---------------GIAEKHHLDIASDYDMDFIRIGSTIEDFPKSSEFIDKAKSLSMMTCVNFMKSYTSKPEKLAIASSAAFEMGVDVVYVVDSAGGMLPNEVKNYVEAIKA---ENTNAIVGFHGHNNLGLGIGNALAALNAGASIIDTSLQGFGRSAGNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9L0X3(1-287:496) Pyruvate carboxylase subunit B n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0X3_THERP  E=3e-29 s/c=0.46 id=22% cov=42%
MAPRIQLIDVTLRDGNQSLWSAIGVDTRtvAEVAPWIDRAGFASIDFttsTHMAISvryhrEDPFEKIRLARLLMPNTplifmttgmRFITWEPAPRAIMRLALRVVVRHGIRRVQIVEPMNNMSaLLEAARIAREEGAEQVVAGLVYSISPVHTDEFYLRCA-----EDLAR-----ERQLLDRVYIKDPSGLLTPERVQTIVPALRRAL--GPDVPLEMHSHCTMGMAPLCYLRAVELGVQTVHTAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0FNJ3(3-248:333) Conserved uncharacterized protein n=2 Tax=Erwinia pyrifoliae RepID=D0FNJ3_ERWPY  E=1e-28 s/c=0.53 id=24% cov=43%
-NSNVILLDCTFRDGGYYTNWNFDEDLVNIYYSAIIETDVDIMEAGYISVDASDcgrfkvenisgFNFLSVIPGKSWAAMIdskSILCLENWHDI--VIHILKKPARPVIDI------IRVATKFNQ-----LDNIDQLCNIISASGYRVALNLMQIDLACEEEVTAVFEKISSIKsIETVYLADSFGSMPPQRVAELITRLK----EITSANIGFHAHNNMGMALINSMTAIQAGANWIDTTFAGMGRGAGNAATEEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1ZXN8(525-826:1165) Pyruvate carboxylase n=5 Tax=Bacteria RepID=B1ZXN8_OPITP   E=2e-28 s/c=0.43 id=21% cov=49%
--KRLLITDTTLRDAHQSLMATrVRTYDMRAVADALAhhAPGLFSLEM-WGGATfdtamrflyEDPWDRLRQLRAAVPNICFQMLLRganavgyTNYPDhvVAGFVRHAASAGMDIFRIFDSLNYL---PNLRVAM-EAVQDTHAVCEAAICYTGDIL----DGKRdkFSLQYYVKLARELERMGAHFLAIKDMAGLCRPYAAYKLVKALREEI----GLPIHFHTHDTSGIAATSVLRASDAGVDVVDLAIASMSGSTSQPNLNSIVAAL----QHTPRDPQLDLERLNAVSDYWEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IEM5(5-254:340) Putative uncharacterized protein n=1 Tax=Pseudomonas entomophila L48 RepID=Q1IEM5_PSEE4  E=3e-28 s/c=0.52 id=25% cov=46%
-TQSFVLMDCTFRDGGFQTDWRFSDAMVGRYFGMCQATGVDIVEMGYlnldPAAGVSHLGSFKALPESLSDVQrqqvdLGPMRAAVMIDAWRILDQPAQAAAEVIMAAIRRSPFPIAILRIAAMSSQLAGSLALAKALAGQELAVMINLMQAAELTPEQLAQDLPALAVEPVTALYFADSFGRMLPEQVHRLFSRARELTP----LPLGFHAHDNYGLAVANTQAALDAGARHADGTFAGIGRGAGNAPTETL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P32327(559-834:1180) Pyruvate carboxylase 2 n=326 Tax=cellular organisms RepID=PYC2_YEAST  E=4e-28 s/c=0.46 id=27% cov=41%
-----LLMDTTWRDAHQSLlatrvrthdlaTIAPTTAHALAGAFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGvaysslpdnAIDHFVKQAKDNGVDIFRVFDALNDL-----------EQLKVGVNAVKKAGGVVEaTVCYSGDMlqpGKKYNLDYYLEVVEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRTRYPDL---PIHVHSHDSAGTAVASMTACALAGADVVDVAIN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0FUY3(1-246:431) Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0FUY3_9FIRM  E=5e-28 s/c=0.52 id=24% cov=44%
MSN-IRLLDCTLRDGGYVNDWKFGHDNLVGIFERLVDANVDIIEIGFlDDRRPFDIDRsimpntacAEKIWKDVehKNVMVVGMidyGTCDISNIQPCCDSFLD-GIRVIF-----------------KEHLMKEAMEYCRQIKKLGYKVFAQLVSVTTYTKESMLELIELVNDVKPYAVSMVDTYGLLKPNTLLEYYEILDEYV--YPEVQIGFHAHNNFQLAYANALAFVSKPNKkhdiVVDGTLFGMGKSAGNAPIELLAMSLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2UP73(4-269:507) Methylmalonyl-CoA carboxytransferase n=4 Tax=Verrucomicrobia RepID=B2UP73_AKKM8  E=9e-28 s/c=0.48 id=23% cov=38%
---------TVLRDGHQSLAATrMKTADMLPIAPILDSMGFSaletwggaTIDAGLRFLKEWPFDRLDALKKAAPKTPHMMLLRG-----QNIVGYTNYAD-DVVEAFVAMSAKHGMNIFR-----IFDCVNDprnmetSIRAAKKAGAQA-HGTICYTTSPVhttQTFVDMGRELADMGADAIVIKDMAGLIPPYVTQELVSALKKDL----NIPVWIHTHDTAGLGASTYLSAIDAGVD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4MW39(2-137:146) 2-isopropylmalate synthase n=3 Tax=Haemophilus influenzae RepID=A4MW39_HAEIN  E=1e-27 s/c=0.93 id=55% cov=26%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKLDGEKLSTSSIgGNGPVDAVYNAILNLTGLEIKMSHYNLTAKGEGAEALGQVDIVVEHKGRKFHGVGLATDIVESSALALVHAINAIYRAHKV------------------
>UniRef50_Q70AC7(11-280:505) Methylmalonyl-CoA carboxyltransferase 5S subunit n=56 Tax=Bacteria RepID=5S_PROFR  E=2e-27 s/c=0.47 id=19% cov=40%
-PREVGITELVLRDAHQSLMATrMAMEDMVGACADIDAAGYWSVEC-WGGAtydscirflNEDPWERLRTFRKLMPNSRLQMLLRGqnllgyrhyNDEVVDRFVDKSAENGMDVFRVFDAMNDPR-----------NMAHAMAAVKKAGKHAqGTICYTISPVH--TVEGYVKLAGQLLDMGADSIALKDMAALLKPQPAYDIIKAIKDTY--GQKTQINLHCHSTTGVTEVSLMKAIEAGVDVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0WAZ1(25-287:465) Oxaloacetate decarboxylase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WAZ1_9FIRM  E=3e-27 s/c=0.48 id=22% cov=35%
----VRLVSCDLRDGQQAAIATrMTTEEMLPVLKPLDEFGFDALEV-WGGAtfdacirflGEDPWERLRIIKAHVKKTPLRMLLRGQnllgyapyPDDvVDHFVAAAARDGIDIFLIFDGLNDVRN--------------VRRAAEAALKAGKKVEANL-QFTSSPVHTVESFIKTARDYldiGATALHLEDMGGMKTPREAVETVKALKATF----DVPVHYHAH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1B6B3(16-296:499) Putative carboxyltransferase n=1 Tax=Rhodococcus opacus B4 RepID=C1B6B3_RHOOB  E=2e-24 s/c=0.41 id=22% cov=41%
--RKIDIVDQTLRDGPQSwWGMRLRKDMGLPMAAELDRTGFHTIDL----AGSSIFEVLVRHCKEDPWEQLISLSKSMPETTVRA-----GTRSNGIVTFGltadSVMDLWVQRLIAHGIGSfwiydglfNIDKIGRLVKTVQAEGgqaLPCILYADTPYHTDEYYAAR-TRELVATGADGIELEDAAGLLTPERTRSLVAAIKGA---AGNLPVEVHFHSNNALAPLNYLEAVLAGADRVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3ASA1(2-277:650) Oxaloacetate decarboxylase, alpha subunit n=35 Tax=Bacteria RepID=Q3ASA1_CHLCH  E=2e-24 s/c=0.42 id=21% cov=41%
--KKIRFMDVSFRDGFQScYGARVRTEDFLPVLEAAVAAGTDNFEIGGGARFqslyfyceEDAFEMMDRAREVVgpdinlqtlsRGANVVGLISQSRDIIDLHARLFKKHGISTIRNFDALMDVRNLAYSGQCIHNAglkHQVVIALMGLAPGLKETYCHTPQFY----LDKLQEILDTGI--PFDSVAFKDASGTTTPATVYETVKGARKMLPSET--VIEFHTHDTAGMGVACNFAAIEAGADII----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4F8H9(22-276:347) 4-hydroxy-2-oxovalerate aldolase 1 n=1 Tax=Pseudomonas pseudoalcaligenes RepID=HOA1_PSEPS  E=2e-24 s/c=0.45 id=23% cov=43%
-----------------------TLEQMIAVPTVLDAPRIPLIEITlrdglggrsinyvFPAHI--DEEYLRAVIPRLKQAKVSALLLPGIGTVD-HLNMALDCGVSTILV-----------ATHCTEADVSE---HHIGMSRMLGADTVGFLMMAHMIRRGKSAGAARLDVKcYGANCIYCTDSAGYMLPDEVSEKIGLLRAEL--NPATEIGFHGHHNMGMAIANSLAGHRGGASRIDGSVAGLGAGAGNTPLEVFVAV----CKRMGVETGIDLYKIMDVAE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8LCZ8(638-943:1291) Predicted protein n=3 Tax=Eukaryota RepID=B8LCZ8_THAPS   E=6e-24 s/c=0.37 id=26% cov=42%
--QNVLVTDTTWRDAHQSlLATRMRTADLLKAAEAtntafngtsdvfsLEMWGGATFDVSMNFLRECPWKRLEELREAAPDMLFQMLLRganavgyTVYPD-NVVYEFCKQAyksGNDIFRVFDSLN-----YVDNMELGiKAAAASGGFVEAAICYTGDVT-SSDPSNKYNLKYYLDFATQLVDLGAHALAIKDMAGLLTPRAATLLVSELRSAFPD---VPIHLHTHDTAGMGVAAMFAGAEAGADIVDGAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6LFD8(1-288:641) Pyruvate carboxylase subunit B n=42 Tax=Bacteroidales RepID=A6LFD8_PARD8  E=6e-24 s/c=0.40 id=20% cov=46%
MKREIK-FSLVFRDMWQSAGKYVPTvDQLTRVAPAIIEMGcFARVEtngGGFEQVNllfgENPNKAVREWTKPFHAAGIQT------HMLDRALNGLRMSPVpdDVRQLFYKVKKAQGTDIARtfCGLNDVRNIA-PSIKYAKEAGMISQCSL-CITHSPvhtVEYYTKMAFELIELGADEICIKDMAGIGRPYTLGRIVANIKEKYPE---IPIQYHSHAGPGFNVASIMEVCNAGCDYIDVGMEPLSWGTGHADLLTVQAMLK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6LCK8(1-290:525) Carboxylase, putative n=7 Tax=Bacteroidales RepID=A6LCK8_PARD8   E=8e-24 s/c=0.39 id=21% cov=40%
MIRKLLIRDLTLRDGQQSAFATrMSQAQIDRVLPYYKDAGFYAMEV-WGGAVPDsvmrylgenPWDRLEIIKEKIGNsSKLSALSRGRnlfgynpypDEIIEGFCRNSIRSGIDIMRIFDALND--------------VDNVKSTIRYVKKFGgkaDCAICYTIDPHHSPVERIKAAlhgrplhkpvftneyflnkALQLESLGADMITLKDMSGLIPPARTAELVRLFKKSL----KVPVDFHTHCTPGYGLASVVSAIINGVDIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6LKZ4(18-268:534) Putative uncharacterized protein n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LKZ4_9FIRM  E=1e-22 s/c=0.44 id=18% cov=38%
------ILDCTLRDGGYINNWKFGGRTIKSIISNLEDAGVDIIECGFIR--KEDHSSDSSVFSSME--QVADIIAPKKANISYAIMIEQHNHVDKL---IPENDGNGADIIRITfRRKEWEEAKVAIKHLICKGYKVCVQPVGTVTYDDESLLKLIKDVNQIKPYAFYLVDTLGVMYRHDMRRFFYLIDNNLSK--EICLGFHSHNNLQMSFANA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0EBA3(623-895:1244) Pyruvate carboxylase subunit B, putative n=7 Tax=cellular organisms RepID=B0EBA3_ENTDI  E=4e-22 s/c=0.40 id=19% cov=40%
--KEILITDTTMRDAQQSlLATRVRTADLLSVAEehscQLDHAfsmemwGGATFDVCYSFLHESPWERLRLLRKRIPNILFQMLLRGRNAvgytnypdnLIKEFVFQAAKNGMDVFRIFDCFNDVSSMVTCVKAVKEAKKIAECCI------CFTGNFMSPDEHIYTLDYYKEVAKKINEIGAHCIAIKDMAGLFKP----QMAKPFMNAMKEVTDLPIFFHSHNTSGT-IINTLIALtEAG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2SNE9(20-235:333) HMG-CoA lyase-like protein n=1 Tax=Streptomyces fradiae RepID=D2SNE9_STRFR  E=2e-21 s/c=0.49 id=26% cov=41%
----VQVTDVTLRDGGYLNDHSWTADRAHAVVRAVSAAGVRRIEVGYANAGAA-FPSPALLGDLVAAAGPATVVMMVKPFGDePDWAALAGRGVGAVRFPVAVARA--------------AELGPVLDRARRAGLETAVNLIRVSAEALDSVVGAAVAAAELGAGTLYVADSNGSLTPHATDELVRALCRAVP----VPIGFHGHDNLRLALANSLAALRAGAAHVDASFDGIGKGGGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4TE53(524-798:1148) Pyruvate carboxylase n=40 Tax=Actinobacteria (class) RepID=A4TE53_MYCGI  E=4e-21 s/c=0.38 id=25% cov=41%
-SKAVGVTDTTFRDAHQSlLATRIRTSGMLMVAPYVARMtpQLLSIEC-WGGATydvalrflkEDPWERLAALREAVPNICLQMLLRGRntvgytpypESVTHAFVQEATATGIDIYRIFDA---LNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSDPAENLY--TLDYYLKLAEQIVDAGAHVLGIKDMAGLLRPQAADTLVRALRSRF----DLPVHVHTHDTPGGQLATYLAAWQAGASAVDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6L5K8(1-289:591) Pyruvate carboxylase subunit B n=28 Tax=Bacteroidales RepID=A6L5K8_BACV8  E=4e-21 s/c=0.36 id=21% cov=41%
MKKEIK-FSLVYRDMWQSSGKYQPRADQLAkIAPLIVEMGcFARVE-----TNGGAFEQVNLLYGENPNKAVRTFTKPLReagiqtHMLDRGLNALRmypvPADVRRLMY-------RVKHAQGVDITRIfcglneVRNIIPSIKYAKEAGMIPQATL-CITYSPvhtVDYYSYIADQLIEAGAPEICLKDMAGIGRPEMLGQLVRNIKDKHPE---VIVQYHGHSGPGLSMASILEVCENGADIIDVAM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5LD66(2-193:196) Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP3-BS71 RepID=A5LD66_STRPN  E=5e-19 s/c=0.51 id=23% cov=33%
----VKIYEETLRDGIQSSELSMlNTEDKKKVIKNFDNAGIEGCCIGFINSSKKENDEINElfqfIITNKLKIVPAVLCRLLIEDFKE-IKNIVQCNLfnqLKVYTYIAVSPIRMK-VENWSEEIIIEKIIDFLNYCQMENAKITIAFEDASRADKSFLKKLIEIINNYPlVKSVVIADTVGTC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2GK06(542-810:1149) Pyruvate carboxylase n=59 Tax=Bacteria RepID=B2GK06_KOCRD   E=5e-17 s/c=0.34 id=22% cov=40%
--------STTFRDAHQSlLATRVRTRDLLAAAPAYAHLlpGLLSIEAWGGATydvalrflGEDPWERLRLLREAMPNIPIQMLLRGRNtvgytpypvEVTNAFVAEAAETGVDIFRIFDALNDV---EQMRPAIEAVRATGTAVAEVALCYTGNL-LDPEESVYT-LDYYLDLAQQCVDAGAHILAIKDMAGLLRPEAARRLVSALRERF----DLPLHLHTHDTAGGQLATLLAAAEAGVDAV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0JMN9(95-272:569) Pentapeptide repeat family protein n=4 Tax=Chroococcales RepID=B0JMN9_MICAN  E=1e-14 s/c=0.47 id=22% cov=24%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGWKIENFEILCANNNLTSATVILCNTKtqERYTESAFKKGSVDALCTAFNEALAHLVEvkhiLKSVYLANLKEGQQGDVTVKVVVEYDGKKVITIHTHENILKAYFFAYVKAMIAVYAPDEYHPDIH-------------
>UniRef50_A7NN81(38-309:685) Biotin/lipoyl attachment domain-containing protein n=4 Tax=Bacteria RepID=A7NN81_ROSCS  E=3e-10 s/c=0.26 id=24% cov=30%
------------------------------------------------------FEEIQILRRLMPNVLLQTLVRetnlwGYRPYPRNVIEyAVAQVDIDVWRCFSFLNDVRNM------------RAVAEVVMKRGRLFEPAISFTVADWATDAYYLGVVREivALAGGVDEIILCikDMAGVGNPARISQLVTTIKEHYPDL---LIHYHRHITDGLAIPALFAAAQSGAKIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1VD30(540-821:1234) Carbamoyl-phosphate synthase L chain, ATP-binding n=9 Tax=Proteobacteria RepID=A1VD30_DESVV  E=0.0001 s/c=0.18 id=24% cov=40%
---HVHFTDTTARDITQSNsGNRFRLAEDALMGPYLDNCNFFSLENGggahfhvammanmtYPFSEAAEWNKFapKTLKQiLIRSTNVLGYKPQPRNLMRITGEMICE-HYQVIRCFDFLNHVenmrpFAEVALNRN-DVVFEPALSL-SWAR--GFDVAHY---VGVT--EAILRMVGDVAGFGPEqasrsiILGLKDMAGVCPPRFMTELVSTLRKRWP---SLVLHCHRHYTDGLFVPAVGAAAKAGAHIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P48571(1-508:518) 2-isopropylmalate synthase n=3 Tax=Buchnera aphidicola RepID=LEU1_BUCRP  E=1e-159 s/c=1.11 id=69% cov=97%
MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIIDMAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDELYASFLKLADKKGQVFDYDLEALAFINQQQEELEHFSLSFFSVQSISNGLSTASVKLLCGKKTFIESAtTSNGPIDAIYQALNRITHFPIILQKYQLIAKGKGKDALGQVDILVEHKKRKFHGMGLATDIIESSAQAMVNVLNNIWKANQVNE----------------
>UniRef50_A8FFW5(2-515:517) 2-isopropylmalate synthase n=224 Tax=Bacilli RepID=LEU1_BACP2   E=1e-153 s/c=1.06 id=46% cov=98%
--RKINFFDTTLRDGEQSPGVNLNAQEKLIIAKQLERLGVNIIEAGFPASSRGDFLGVQEIARTIKNCSVAGLARCVKGDIDAAWEALKDGVEPRLHVFIATSDIHLKHKLKKTREEVVEQAVAMVKYAKERFPVVQWSAEDACRTDLDFLAEIVEKVIDAGASVINLPDTVGYLAPKEYGNIFKYMKEHVPNIDRVNLSAHCHDDLGMAVANSLAAIENGADQIETAVNGIGERAGNAALEEIAVALHIRKDFYQVESTIQLNEIKRTSDVVSKYSGMIVPRNKAVVGNNAFAHESGIHQDGFLKEKTTYEIISPELVGVTTDVLVLGKHSGRHAFKDRMKTLGFKLTEEEINKFFETFKNLTEKKKEITDDDLISIILEEKVADRKIGYEFESLQVHYGTEQMPTATVSLKNQEtqEVIQEAATGAGSVEAVYNTLERCMEERIHLLDYRIQSNGKGRDALAEVYVTVSIEGKETAGRGVAQDVLEASAKAYVNAVNRhlIFKSNLIEIEKHHA-----------
>UniRef50_C7JAV8(36-544:547) 2-isopropylmalate synthase n=8 Tax=Acetobacter pasteurianus RepID=C7JAV8_ACEP3  E=1e-146 s/c=1.02 id=45% cov=97%
-PDRVIVFDTTLRDGEQSPGFSMNLAEKLRMAEALANLGVDVIEAGFPVASKGDFESVNEIAKNTKGSVICALARsGGVKDIAAAGEALAPAERKRIHNFISTSPLHMKYKLRMEPETVLELITSGNAAARNLTDDVEWSAEDGSRTEPDFLCRCVEAAIKAGATTINIPDTVGYATPEDMEKIFSMLRQRVPGADQVIFSAHNHNDLGLAVANTLASIRGGARQVECTINGIGERAGNAALEEIVMALRTRHDQYPFTTGIHTEGLLKVSRMLATITSFDVQPNKAIVGRNAFAHESGIHQDGVLKNAATYEIMTPESVGWTRSSLVMGKHSGRAAFRDKLKVLGYEgMDETRLNEAFTRFKDLADRKKVVYDDDIIALVDDEARDHDRIRFGALSLK--SISGQPSEVDLELSVDGKAIEAKATGNGPVDAAFNALRKAFPHEARLALFSVGAVTEGTDAQARTTVRLEEAGKMVDGQGADADTVVSAVRAYVHALNKLLvKRARTEPE---------------
>UniRef50_UPI0001C31767(8-511:528) 2-isopropylmalate synthase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31767  E=1e-142 s/c=1.01 id=47% cov=96%
-PNQVLIFDTTLRDGEQSPGISLNTSEKLEIAQQLARLGVDIVEAGFPIASPGDFEAVETIARQVEGPVIAGLARIHVGDIDAAWNALRDASRPRIHTFVSTSDIHIEHQMRSTREDVIGLTRAGVAHAKQYVDDVEFSPMDATRSDVEFTAEVVQIAIDEGATTINIPDTVGYTMPHEYTAFLGRLYELAPGLRDVVLSVHCHDDLGLAVANSFAGVLAGARQVECAINGLGERAGNASLEEIVMLLRTRQADIGLDTNAVSQEIARASRLVSRMTGYAVQPNKAIVGRNAFAHESGIHQDGVLKNRETFEIMDATSIGLDSNSLVLGKHSGRHALRDALAQLGIVVDGATLNTAFKRFKEIADKKKQVTAMDLEALVTDELREEIPA-YALEWFEVEASSRRPPHARVGVTLpDGSEATGSFTGDGPIDAVFHAINAATSVEAKLRDFRIDAVTSGQDALGETSVVLEVDGVSGAGQGVSTDIIEAAGRAYVRALSNAVRRRSV------------------
>UniRef50_D2RHN2(2-498:498) Isopropylmalate/citramalate/homocitratesynthase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHN2_ARCPR  E=1e-140 s/c=1.01 id=37% cov=94%
--RTIKVFDTTLRDGEQMPGVSLPVNYKIQIAKQLDKLGVDVIEAGFPSASKGEFEAVKEIANLGLNAKICGLARVVKKDIDQAIK----ADVDIVHVFIPTSKIQVEHTIKKTPDEIVQLSVDAVEYVKSHGVECMFSAMDATRTEMDFLKRIYKAVEEAGVDIINVPDTVGIATPFRFYDMIKKLKEHL----NVPIDVHCHNDFGLATANTYAAVLAGADEVQVTVNGLGERAGNAPLEEVVALLYA----EGFKTNIRMEYLVETSRLVERLTGVKMPPNKPIVGENAFSHESGIHAHGVLKDARTFEPgiITPEMVGH-KRRIVVGKHAGRHQIKKILEDAGYVVDDEKLSIIVQKVKELGDKGKKVTDLDLFAIAEsvLGEVSEKDRIINVDEVTVLTGNKITPTAVINAEVEGERKVTSAIGVGPVDATFKAVTELLGRKIKITEFRLDAITGGSDALANVYVTVEDeDGETFTARSAGADIVMASFDAVIKAVNYLMLKKKRKK----------------
>UniRef50_P58968(17-513:516) 2-isopropylmalate synthase 2 n=19 Tax=Archaea RepID=LEU12_METMA   E=1e-138 s/c=1.00 id=38% cov=94%
-SKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVKSISNAGLDTTVCGLARVLKKDIDACFES----DVGLVHTFVPTSDVQRIYTIKKSREEVIQLAVEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMYRQIKGIAAEIT----IPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADLSQTVMSLTS---IYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESGIHSQGVLEKSDTFEPgiMTPEMVGH-RRRIVLGKHTGKHAVKQSLESAGIKTNDNQLDEIVIRIKEIANKGKQITDADLYAVasAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGKEIIAARTGVGPVDAALHAVRDILGEsnHFRLQDFRIDAITGGADALADVYIGLEnEKGRIVTARSANPDIVMASVEALVNAMNLLYKKE--------------------
>UniRef50_UPI0001C42034(2-494:497) citramalate synthase CimA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42034  E=1e-137 s/c=1.00 id=34% cov=93%
---KIEVLDTTLRDGEQTPGISLNTIKKLRIATKLDEIGVNSIEAGSAITSEGEREAIKAITSQGLNAEIVSFSRTLIKDVDYCLE----CDVDAVNIVVPTSDLHLQYKLKKTQDEMLEDAVKVTEYAKDHGVKVELAAEDSTRTDIQYLRKIFKATIDAGADRICPCDTLGILTPLKSFNFYKQFTDL-----GVPVSAHCHNDFGLAVANTLSAIDGGASRFHATINGLGERAGNAALEEVVVSLYTLYKDEsnerKYETDIKIDQIYSTSKLVSRLSNAYLAPNKPIVGENAFAHESGIHADGVIKNSATYEPIMPELVGH-RRKFVIGKHVGTKGLNNRLEELGLEVNKKQLNDIFYKVKDLGDKGKTVTDTDLEAIAEHVLNIEQEKKINLDELTIVSGNKIRPTASIKLNIENEEVIEADVGIGPVDAAINAVNKGIKsfADIQLEEYHVDAVTGGTDALIEVIIKLSSGDKIISARATEPDIINASVEAYIDGVNRLL-----------------------
>UniRef50_Q1ARE2(2-485:510) 2-isopropylmalate synthase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1ARE2_RUBXD  E=1e-135 s/c=1.00 id=46% cov=93%
--RRIQIFDTTLRDGEQSPGISLSVEEKVEIAHQLARLKVDVIEAGFPITSEGDFEAVSRIASEVEGPVIAGLARIHQEDIERAWEAVRWSRRPRIHTFVGTSDLHIEHQMRSTREEILSGAAEAVRLAKSLCENVEFSPMDATRTDIGYLAEVVAAAVEAGADVINIADTVGYTTPAEFAAFLRELKERVPGLAERVLSVHCHDDLGMAVANSLAGVEAGATQVEVAVNGIGERAGNASLEEVVMALVTRKDYYGVEVGVETRQLANTSRMVSNMTGYDVPPNKAVVGRNAFLHESGIHQDGVLKDRRTFEIMKPADIGLEGTNIFLGKHSGRHALKEALADLGYTLEGETLKRAFKRFKELADHKKTVTAADLEAIAAD-EVGSFEGKFVLESFRVVAATGRQSRAAVRIAHADRgTFEAEAEGEGPVDAVFRAIDSATGIKGRLTDFRIDAVTGGKDALGEVRVTVEFEGTECAGRGLSQDVVE-------------------------------------
>UniRef50_Q2S0M7(1-528:546) 2-isopropylmalate synthase n=3 Tax=Bacteria RepID=Q2S0M7_SALRD   E=1e-135 s/c=0.92 id=46% cov=97%
MSDSITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQTEAVTRIATEVDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIEAKFDKlgntmaeKREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATTINIPDTTGYCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQVECTINGIGERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNKAIVGSNAFSHEAGIHQHGVLEERTTYEIMSATDVGQDAEQIRLGRHSGRHGLFNRLEAMGYAVPEGHRDALYDRFLDLADRKKEVFEEDLEQMMNDfggdavaaatglpdngVALNGGTPAYRLDQFSVHLSSDDEAKVSVRLqRDDGSAREEQATGEGPVDALYRALDHAVDAPHTLVDYSIRSISEGADAQGEVEVTIRYGENQFAGTARNTDVIRASAEAYVDALNRLVAAQE-------------------
>UniRef50_A8V4T9(12-432:432) 2-isopropylmalate synthase (Fragment) n=2 Tax=cellular organisms RepID=A8V4T9_9AQUI  E=1e-126 s/c=1.08 id=54% cov=80%
--RKLIIFDTTLRDGEQAPGFSMTVEEKVRMAKQLEKLGVDVIEAGFAAASKGDFEAVNEVAKEVKNSTVCSLARALHSDIERAGEALAPAERKRIHTFIATSPIHMEYKLRMTPEQVLERAVDAVQFARNFTDDVEFSAEDAVRSEREFLYRIFEAVIAAGAKTINVPDTVGYAVPEEFGQLISDILNNVPNIDKAVISVHCHNDLGLAVANSLTAVKNGAGQVHSTINGIGERAGNAALEEVVMAIKVRKDYFkDVYTDINTKEIYRTSRLLCRLTGSFVQPNKAIVGDNAFAHEAGIHQHGLLAKRETYEIMKAEDVGVPSSKIVLGKHSGRHAFKTRLEELGYKnLSEEEIDKLFAKFKELADKKKEVFDEDIEALLFDELFKSYE-EVKLLQFQIVSGNKAIPTATVKLKIDGEEIVST-----------------------------------------------------------------------------------------------------
>UniRef50_Q18KM5(23-504:531) 2-isopropylmalate synthase n=9 Tax=Euryarchaeota RepID=Q18KM5_HALWD   E=1e-124 s/c=0.93 id=36% cov=92%
----VQLLDTTLRDGEQAPGISLDPDEKAEIARELDRSGIEFIEAGSACTGEGERETIRQVTGLDLDATVTSFARGVKSDIELAVD----CGVDGVTIVVPASDQHIETKVGSTRSEVVTTTAELVEYAKDHDLWVEVIGEDGSRADIEFLERLMREALDAGADRSCYADTVGHANPETTYEYVSRLAALGP------VSTHTHDDLGLAMTNVWVSLAAGADLVHGTVNGIGERAGNVALEEVAIAL---AHGYDIETAT-LDQLYSLAQTVSQATNIPLPPNKAVIGENAFTHESGIHTDGTLKDKTMYEPYSPSSVGR-ERRLVLGKHAGRAGVQAALDEHRIDVSEDEVTAIVDRVKELGDRDKRVTDADLLTIAEEVQGRERDRHVELLDLTAASG-GGTPTASIRLRVGENERVASGTGSGPVDAAVEAVRAALGtdADAQLDSYHVDAITGGTDAVVTVEVEMSRGDRTVSVATSDSDITRCSVEAMVEALDRLL-----------------------
>UniRef50_Q7VH30(26-558:558) 2-isopropylmalate synthase n=16 Tax=Bacteria RepID=LEU1_HELHP   E=1e-115 s/c=0.78 id=24% cov=94%
-----IWCSVDLRDGNQALITPMSLEEKITFFKLLLKVGFKEIEVGFPAASETEYRFLRTLIEEdliPDDVSVQVLTQAREHIIKKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDEIKHIACEGAiclkesAAATKGNFRFEYSPESFSGTEVDYALEVCNAVIDIFEPTlekkliINLPVTVEMSLPHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAELGLLAGADRIEGTLFGNGERTGNVDIITLAMNMHSH----GVDPKLDFSNIPSICDVYEKVTKMQVYERQPYSGKLVFAAFSGSHQDAIAKGMAYhkehnlstwsvpYLPIDPKDVGRvyESDVIRINSQSGKGGIAYILHHHyGVNLPPLFREEFSYYVKNISDKAHKELSPDEICEIFQNDFVNLNNTLCVQDFHFTHiDSKPSQEFNVKLhilyakENSKTQQEITGKGNGRLDSIANALREHLNLDFEIIDYSEHSLKKGSTSQAVSYVQIESKGKKCFGVGIDNDIITASIYGLVSALNRII-----------------------
>UniRef50_B2AHM5(27-550:569) 2-isopropylmalate synthase n=69 Tax=cellular organisms RepID=LEU1_CUPTR  E=1e-115 s/c=0.80 id=24% cov=95%
ITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRMLIEErriPDDVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGTRLIKALTDampetawTYEYSPETFSLAELDFSLEVSDAVSAAWqagpgrPMILNLPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQ----GVAPELDFSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAqqqpdaiwevPYLPIDPADLGRSYdAVIRVNSQSGKGGMAYLLEQvHGLYLPRRLQIEFSRAVQAMTDDTGLEASADDLYGLFRREYLARETPLRYVSHQLASDATGATAITVQMERDGQPCTVRGTGNGPIDAFIDAL----DLPVRVMDYHEHAMTAGADARAACYVEVRVGDSpTGFGAGIDASLVTASLRAVVSGVNRHLQAG--------------------
>UniRef50_Q02CM5(2-511:536) 2-isopropylmalate synthase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q02CM5_SOLUE  E=1e-114 s/c=0.82 id=28% cov=93%
---KIFTFDTTLRDGTQGESISFSVDDKLIIAQKLDDLGIDYIEGGWPGSNPKDKDFFARSGELnLKHSKLTAFGSTRfaknPVEEDRNVKALVEAGTPVVSIFGKSWDLHVRRALGISLEENLVLISDTVGYIHGHGREVVYDAEhffDGYTADPDYALRTLEAAHKAGASVLCLCDTNGGTVTGRLVEIVAEVRKRFDG----IIGIHTHNDGDLAVANTIAAVEAGATHVQGCMNGYGERCGNANLASVIANLELKLGHTTVGPE-KLAGLSSTCRFIAELANLPLRNDQPFVGKSAFAHKGGVHVSAVLKDSATYEHIKPEAVG-NRQRVLVSDLSGRGNIIYKLKQHGLaDRLEEDTRRVLLERIKQMEYEGYELEAAEGTFELLVREALHPgmHFFDVESYEVSTraagNAASHSTATVTLKSQDGVHSATETGHGPFDALQVCLRKCLSklypqiVDVRLTDYKVRVLdtNKGTAANVRVLIEWSDHRRSWSTVGVSDNVIEASWKALVDAI---------------------------
>UniRef50_Q12166(58-600:604) 2-isopropylmalate synthase 2, mitochondrial n=8 Tax=cellular organisms RepID=LEU9_YEAST  E=1e-114 s/c=0.76 id=27% cov=95%
-----RWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPdDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDdpsqqatrwsYEFSPECFSDTPGEFAVEICEAVKKAWEPTeenpiiFNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQ----GVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELVVSAFSGSHQDAIKKGfaiqnkkqaqgetrwRIPYLPLDPKDIGRDyEAVIRVNSQSGKGGAAWvIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYnynNNEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLSVQNYSEHSLGSGSATQAASFINLSyikdinnHATSNMWGVGVSEDTGDASIKAVFATVNNIIHSGDV------------------
>UniRef50_D1AJT6(3-513:529) 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=D1AJT6_SEBTE  E=1e-113 s/c=0.80 id=29% cov=93%
---KVEVFDTTLRDGAQARGISFSVKDKIAVTQALDAFGIDYIEAGNPGSNPKDLEFFELVKSvELKHSKLVAFGSTRRKDVapeeDQNLISLLQAGTEYVSIFGKSWDFHVTDIIKTTLENNLEMIKDTLLFLKSKGKKVIFDAEhffDGYKNNPEYALEALKAAKDGGAEILTLCDTNGGCFPEEISRITKEVKEKL---GDIKIGIHAHNDMGFGVANSIAAVEAGALQVQGTFLGYGERCGNANLSTIIANLQLKKD-YELVPREKLGLLTSTARIIAEISNITIEDSMPYIGKNAFAHKGGMHIDGVSKASHSFEHINPELVG-NEREFLLSEVSGRSTILEEIRRVdkDIQRDSEATAGIIERLKEL-EYQGYQFEGakATFELVIRKYLGKYKPFFDLVYFDVKGnyiGKKYYSTAVVKVKVKDQIELTVAEGDGPVNALDQALRIALERfypelkEMHLIDYKVRVLKGeenATASKVRVLIESADAKNSWTTIGVSTDIIEASWIALVDSI---------------------------
>UniRef50_A8HXS9(2-439:444) Isopropylmalate synthase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8HXS9_CHLRE  E=1e-108 s/c=0.90 id=42% cov=80%
-------------------------------------------------------------------------------DLERAWDAVRHAKRPRVHTFIATSEIHMKVSQQGSATSGLHNAVAAVKHLRSLGCtDIEFSSEDAGRSDPKFLYRILGEVIKAGATTLNIPDTTGWCLPHEFGELIAAIKKNTPGADNVIISTHCQNDLGLSTANSLAGAQAGARQIECTINGIGERAGNASLEEVVMAIKLRG------------------KMVSDYSGMVVQAHKAIVGANAFAHESGIHQDGMLKNRETYEIMSPESIGLPRQEqdrgIVLGKHSGRNALNSRLRTLGYELSQSELDDVFKRFKALADKKKGITDEDILALMSD-ELHQPKVIWELLDLQVVCGTMGMPTATVQMKGPDGIaRIGVGVGTGPVDAAYKAVDSLVRVEAELSDYSVSSVTQGIEALAHTRVMIRPSGkmsdagysehaalgtvqRQFSGSGANEDIVVASARAYVSALNKMIGWRRVGRRREWAS----------
>UniRef50_B1L4G2(2-494:495) Pyruvate carboxyltransferase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L4G2_KORCO  E=1e-104 s/c=0.78 id=31% cov=92%
----IRIFDSTLTLGEMVPGVSFGLEGKLEIASHLDTLGVDVIEAGFPASSEGekrvvreVVRNVKRLSRSGLSPEVCALARAIREDVKAAVE----TGVDSVNIFIPASRLLLERAYGMREEEARERVREAVSLAKSHDLTVEFTAEDAGRSD-DLLWDLCRIAEESGADRINLSDPVGAMLPDDAKKIVLEAKKRIRK----PISVTFSNDLGMATANSLSAAIAGADQIHVSVNGLGPKAGIAPLEQVVVGLKKLA---GLDTNVKMELLPSVSEAVERISGIPISEISPIVGPLVFTYEAGVHVSAISNELSSYEIVSPGEVGR-VRRFWVGTHSGRKAVKEVLKEMGYSASDSDVERILARVKELSQEGIRITEAIFRSVVEEV-LGERPRLFKVKEWVAVTGSGITPTATIRALIGGREVISSSSGVGPVDAITKAIRSIQGIPsFNLRRFRLIAVSSGSEAIAELKIRVVGPKGEVEAAGTSRDIVDASLKAIEEAVNKII-----------------------
>UniRef50_Q3A2Q7(9-382:400) Homocitrate synthase 1 n=18 Tax=Bacteria RepID=Q3A2Q7_PELCD   E=3e-97 s/c=0.96 id=34% cov=71%
----IIIDDTTLRDGEQTAGVVFSLEEKKTIARMLDDIGVQELECGIPAMGREEQRSVKALVDLGLHARLITWNRALVDDIRASLQ----CGVNAVDISLSVSDLHIRHKLRKDRHWVREQLKRALGFAKQHDLYVSIGGEDASRADLDFLVELMELARSMGADRFRFCDTLGLLDPFVTFEKIRYLTQRV----DLDIEVHTHNDLGMATANAIAGVRAGARFINTTVNGLGERAGNAALEEVVMGLK---HACGVKCPIDTSRFVEISRYVGAASNRPVPAWKPVVGERVFAHESGLHVDGVLKDPRNYEPFEPHEVGSSRL-LVLGKHTGRHGLAARVKGLGLDPGDICLSTLLRRIRAISQRRKRpVEDAELEGLYRSLAQASQP---------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3MPM7(3-404:461) 2-isopropylmalate synthase n=19 Tax=Thermoprotei RepID=LEU1_SULIL   E=9e-93 s/c=0.85 id=34% cov=66%
---KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKKEgiitSEIVGHSRAVKRDIEIAAEL----EVNRIAIFYGVSDLHLKAKHKATREEALRTIAETISYAKNHGVKVRFTAEDGSRTDFDFLVTVSKTARDAGADRVSIADTVGILYPSKTKELFSALTREVPNLE---FDIHAHNDLGLAVANALAAIEGGATIIHATVNGLGERVGIVPLQQIAAAIKYHFGIEV----VKLDKLQYVSSLVEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVLNDPRTYEFMPPETFGRTR-DYTIDKYTGKHALRDKYEKLGVKISDAEMDQILAKIK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q52070(18-377:400) Homocitrate synthase n=9 Tax=Gammaproteobacteria RepID=NIFV_ENTAG   E=2e-87 s/c=0.90 id=31% cov=67%
----VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRRQLPDTVMMSWCRMNSAEIHDSAR----VGMDWVDISVPASDLLREQKLHRPWPAVIASLKPLVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGILDPFSTFTRISALRQHWHGG----LEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAALESVTLSL---DRCLHLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTHESGLHVAALLRDPRSYQGIDPSLVGR-EFNLVLGKHSGRQAVSGICARLGYILSETQTLLMLQEVKRFAE--------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6HVD7(14-377:392) 2-isopropylmalate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVD7_9BACT  E=4e-83 s/c=0.85 id=33% cov=66%
--------DTTLRDGGQSPGVFFDRPTKMAVVTTLSRIGVKEIEVGSPCLGEREHEDLKVLLSLPVPAEIFPWLRPVEEDFDAALRL----GFRRVHISFPTSDLHMAVLRRVGREETLDRVRRAVCRMVEEGCRVSVGLEDASRAEMGFLRDIIKTVQDAGGIRVRYCDTVGRHHPLEMSERISALASC-----GLPIEVHCHNDLGLATANTVAAFHAGAAFLSTTVTGVGERAGNAAMEEVAFALAFSGE--GGETGIDFPGLAHISRWLYTAIGRTLSPFRPIVGSRIFHHSSGIHVDGVIKEPSNYELFPPELVGL-KRKIIVTHQTGRAGIKNVLERMGYRPTSEVLDRLVPVIREEG---------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9VAW1(39-394:564) Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAW1_MONBE   E=4e-81 s/c=0.85 id=26% cov=67%
------IIDTTLREGEQFSSTDFTSHDRVYIAKLLDTFGVDYIELVNPFASHQAREDCRAIANLGLKAKIVAHTRCHMDDVRACVE----TGIDGVSMYMATSEALRRHSHGKSVQAVIDSAREVIEFVKDNGMEVRFSCEDTFRSDRTELLDIYAAIDELGVNRVGLADTVGIATPFQVAETVAAVRSIIKPETG--IEFHTHNDTGCCIANALVALQAGATHINTCVLGVGERNGITPLGGFLARMYTL-DRESVKNKYDLKLLRHLEKYVAAAAKVQIPFNNYITGSSAFTHKAGVHSKAVMSDPGAYEVINPDDFGVGRNIEIAHHLTGWNALKARSMDLNLTIPDDQIKAATKMVK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7M8U7(2-375:376) HOMOCITRATE SYTHASE 1 n=1 Tax=Wolinella succinogenes RepID=Q7M8U7_WOLSU  E=6e-81 s/c=0.81 id=29% cov=63%
----ITINDTTLRDGEQAPTVAFTQEEKCEIAKLLYEAGADELEIGIPAMGEAEREDIRAILSLGLPLRLMSWNRATQSD----LEASLACGMKAVDLSIPVSTKMVAAKFRGKYAKVLSNLEETLTIAKKEGLFVCVGMEDTSRANARFLKEVIALAMERGADRVRFCDTVGILTPLQTYRAIRSLRRHCT----LPVEMHCHNDYGMAVANSIAGIEAGAQSVNTTVIGIGERAGNAGFEQVLLSLI---GQFGQNRTLDSTILKALVQKVAKAAGVALAPTAPVVGSRLFWHESGIHADGNQKSEGLYEPFSPELVGASR-EYPIGKHSGSANLIYHLKQF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8FRV4(27-397:404) 2-isopropylmalate synthase n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV4_DESHD  E=6e-79 s/c=0.80 id=26% cov=66%
LPQKIEIHDATLRDGEQTPGVVFSKEDKVRIAELLAEVGVERIEAGMPAVSKDDAQAIEEIAKRNLGPKIMVFCRAMREDVDRAVD----CGADGIVLEAPSGYPKLKYQFasKWTEESLTEAVVNTINYAKEKGLFVNYFPFDTTRAELPFLKRLLTNVtTQAKPDSVTVVDTTGSITPTAMRFLVRQVRETIA----LPLEVHTHNDFGLGTATTFAAVEEGVQVVHSCINGLGERTGNTALEEIALGLKLLYGIE--LPKFNFQKLSELSQEVQRMSGKTLAQNKPVVGLLPFTREIGL----GMKVLEDYptavFPFMPDFVG-QKMKIVMGKKSGKESVLMKLEAAGLKANEEQVQEIVARTK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1U2X4(2-375:377) Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U2X4_9DELT  E=1e-69 s/c=0.71 id=27% cov=62%
--------DTTLREGAQLFGAYFTLDTREAIIAGLLDLGVEEIELGWVGQ-EGLETLVRTMRKRAGATRLSVWSPCREADVRAAA----GLPVDCVNIGVPVSDAHMEKRLGMDRQAVLERITSTVLAARLMDVSaVSVGLEDVSRSDLGFALTAALTAAEAGASRVRLSDSLGILTPVRMQALIDLFRPAL----DIDLAVHCHDDFGMATANAVTALDAGADYADASVLGIGERSGIAATEELAAHLCLNGNNSPCRP-YRTDGLRALCRFVSKAAGVPIPRTKSIAGDDIFACESGLHAHALSKSPDLFEPYDPARIGAGRR-IAVGGKSGRGAVVNALADF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0GSN3(29-388:399) Pyruvate carboxyltransferase n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GSN3_9DELT  E=5e-69 s/c=0.73 id=25% cov=69%
--KKVFmLIDTTLREGDQRYGLYLSLEQKKVIVDGLHRLGLDELETGSVGRDEELETLIKYARQHHGSTKISLWSPCRIQE----LEYADSLDPDIISAALPVSDLHIEKRLGLDRCGALRLLERTLAGTDKLKAKLSLGLEDFSRADREFALRAALMARDLGVWRVRLSDTLGVMEPGELMEAVRPFREKL----DISLAFHGHNDFGMATANALTALSCGVDYVDVSLLGIGERAGIARLEEVLTFLVYNKG----HAGYDVQSLPELSTCVAGLAGVHINPDRAVLGRQLFHCESGLHADALYKSFDLFEPFEPHKMGMQRR-ISLGRKSGAGAVRGKLMEMGVNPDFVDLEGLVRDVRRAASIKGSPLDDE-----------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P70728(1-338:376) Homocitrate synthase n=1 Tax=Azospirillum brasilense RepID=NIFV_AZOBR  E=1e-67 s/c=0.77 id=32% cov=58%
MAGSTIINDTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRAVASLGLKARLMVWCRMHDTDLKARSTAVAPS------LSVPVSDIHITKKLNGSRAWALREIERKVKTARDHGLEVSLGGEDSSRADMDFL---IAAATVAQRPRFRFADTLGVLDPFQHARLHLTAAATDPE-----IGYHAHTPRLANATAwvTLAAVLGGATHVNTTVNGLGERAGNAPLEEVVVSLKV---LYGQDCGVDTRALGAISDLVERASNRPVAVNKSIVRDAVFTHEAGIHVDGLLTDRAPTRISTPPRWG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4QUQ8(10-532:633) Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUQ8_MAGGR  E=3e-67 s/c=0.49 id=26% cov=63%
-----IWLSTDLRDGNQSLTAPLNSDQKFEFFKLLVEIGYKEIEVSFPAASNVEFEFTRRLVETpgavPDDVRLRALAPTRNDFLKRTVDALEGAKRATVCTYICVSDKMLKYQ-GFSRARAIEQAVGAVRYLRSITKdnpdtktrwDLAFGLESYNESDQDFALAMTEAvmgAWEASADdqmWVVLATSTEVATPNVFADQVETFIAGLSAPENVLISIHTHSDRGCGAAAAELGMLAGAHMVEGCLFGNGERAGNVDLVTLALNLYTR----GISPHLDFSDLYAVRDRYEQLTGLQVTARTPYAGEYALQAFSGHHQNIIRKGMGlrlraeaegrpapvwdiPYLPVDPQDLGIPiDHIIRVNSQSGKAA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0Z7H0(2-311:472) Alpha-isopropylmalate/homocitrate synthase family protein n=5 Tax=Bacillales RepID=C0Z7H0_BREBN  E=9e-67 s/c=0.83 id=31% cov=59%
-----QILDATLREGEQQAGVRFTCEDKIRILHLLESYQINLIEVGHPGISALDEEICRKVAQSARRAQILMHARATVEEVHAA----KRAKADWVGIWASINDVSIQTKFRHHEESyILEKVQQAVIEAKKLGLQVRFTIEDASRTEWEKISSLGYAALQAGADRISLADTVGIWEPDTCKKIVTRAIEEF----GCEIEVHLHNDFGLAQANALAAIDAGASVIDATILGIGERAGITDLIQLTVAL----QKLRNDHRYSLDRIPELVQAIRLTTGYRPDELRPITGQNAFTHTSAYHVQAVKRNSKAYEPLPPETIGRTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9YAE2(1-221:285) Putative uncharacterized protein n=1 Tax=Curvibacter putative symbiont of Hydra magnipapillata RepID=C9YAE2_9BURK  E=1e-66 s/c=1.16 id=56% cov=42%
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVQLIANSIKDSTVCSLSRANDRDIARAAEALKGANSARIHTFIATSALHMEKKLRMTPEQVLEQAKQSVRFARNLVADIEFSPEDGYRSDPDFLCRVLEAVIAEGASTINVPDTVGYAVPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4WHZ2(5-403:411) HMGL-like domain protein n=1 Tax=Synechococcus sp. PCC 7335 RepID=B4WHZ2_9SYNE  E=1e-60 s/c=0.59 id=25% cov=61%
----LLISDETLRDGEQQVGLFF--EDKTTLANLIAQTGVQQI-ALMPAIHTSEAKLVSSLVDSGLKRQIVASTMMRR----AAIEHAKTCGVRQVILFHAVSDrlLFLRDleiakdprfkgktidddidlpVIQRSRQRMLIHALEHVRYAAEQGLRICFAAEDASRADNDFLVECINTLSPY-IDEFLLCDTVGSLTPKRTALWIQNLLQH---TRAVPLSVHFHNDMGLALENTIQAVCAGARGISGTFGGIGERAGNAPIEQVLKGLRSRFGWE--VAGIDYDALDQV---VDYLHAQGHRPHAPYS-RQAQRHESGIHVSALLRDRRSYSI-----FPHQQPEIWFGKGSGSSNFQYLFEQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P35914(29-312:325) Hydroxymethylglutaryl-CoA lyase, mitochondrial n=241 Tax=cellular organisms RepID=HMGCL_HUMAN  E=9e-56 s/c=0.77 id=24% cov=49%
LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTsfvSPKWVPQMGDhtEVLKGIQKFPGINYPVLTPNLKG-----FEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEgkispaKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVP---LAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGgcpyaqGASGNLATEDLVYML----EGLGIHTGVNLQKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2RAU5(89-372:387) Hydroxymethylglutaryl-CoA lyase, mitochondrial, putative, expressed n=8 Tax=cellular organisms RepID=Q2RAU5_ORYSJ  E=3e-55 s/c=0.77 id=23% cov=50%
LPRFVKIVEVGPRDGLQNEKSTVPASVKIELIHKLVASGLSVVEATsfvSPKWVPQlaDAKDVLQGIRHVPDVRFPVLTPNLRG-----FEAALAAGAKEVAVFASASESFSKSNLNCTIKESLVRYRDVVTSAKKHGMRIRGYVSCVVGCPVEgtihpsKVAYVAKELYDMGCSEISLGDTIGVGTPGSILAMLEAVMSFVPVD---KLAVHFHDTYGQALANILVSLQLGINIVDSSVSGLGgcpyakGATGNVATEDVVYML----HGLGIETNVDLNKLMDAGDYISK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8QZK2(2-338:399) 2-isopropylmalate synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QZK2_9DELT  E=2e-54 s/c=0.64 id=26% cov=62%
----VGLIDSTLREGLQGVGVELSLDRQVAVAAGSVALGLEELEvgpVGLAAATMEPGDYLARLIPRLRHEagvrRLALWCRCLPDDIERSL----ALNPDVLALSIPASHRQMTSKLGKTAAEVRTLAAAALELARGRVPYLALGLEDVTRAEPNFVRQMAVLAVDHGVDRLRLADTVGISAPDEIADLVGRVREYLREAGGdgrgnqVAIGVHTHNDFGLAGANAIAALAAGADWADVSLLGLGERAGLARLEEVATYLALRRG-----HHYRLERLPELAQQLAGFCGREIPSWRPVVGRDVFSCETGLHLAAIQLDPASYEPFAPELVG-QRRTLLYGVKAGHRAIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8WG57(39-322:335) Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=47 Tax=root RepID=HMGC2_DANRE  E=2e-54 s/c=0.76 id=23% cov=41%
------------RDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKwvaqmADHTAVLKGIKRSPDVRYPVLTPNI-----QGFQAAVAAGANEVAVFGSASETFSRKNINCSIEESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEgqvkpsQVTKVAKRLFELGCYEVSLGDTIGVGTAGSMAEMLSDVLTEVPAG---ALAVHCHDTYGQALPNILIALQMGVSVVDASVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JC95(2-284:308) Pyruvate carboxyltransferase n=5 Tax=Gammaproteobacteria RepID=A3JC95_9ALTE  E=7e-51 s/c=0.72 id=24% cov=51%
---KIRINEVGPRDGLQSQGKTLSVEDRLSLIQALVKVGLKNVEAGsfvSPKAVPQMAgtDDLFALLPERSAVRYAGLVPNMKG-----YELAVAAGANVVNVVLSVTETMNQKNIRMSLPQTVEVCTAIIERGRCEGVEVQAYLAVAFECPFEGLVEpavvarLAKRLEQAGASKIIIADTIGAANPEHVRRLLNGV---ISEVGSDILSCHFHDTRGIALANITAALDHGIREFDTSIGGLGgcpfspGATGNVATEDVVLLLNS----MGHDTGINPFDLVPVVCLAEQLTGVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7MUV0(18-307:314) Hydroxymethylglutaryl-CoA lyase n=5 Tax=cellular organisms RepID=C7MUV0_SACVD  E=9e-51 s/c=0.70 id=25% cov=51%
LPERVTIWEVGPRDGLQNERTTVPVDVKLEFLDRLADAGLTTVEATSfvhPKWVPQlaDAEELLARLRRRDGVRYPVLVPN-----ERGLDRALAAGVTHVAVFASATESFARRNLNSGLDAQFAMFEPVIARAREAGLDVrgyvsmCFGDPWEGIVPTEQVVTVGRRLLDAGCTQLSLGDTIGVATAAAVERLLDAFIE--GGVAIADLAVHFHDTYGQALANTLAALRKGVTTVDASAGGLGGcpyaesATGNLATEDLVWLL----DGLGVEHGVDLDALVETSRWMSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8FDY7(3-291:302) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacillus pumilus RepID=A8FDY7_BACP2  E=1e-50 s/c=0.70 id=23% cov=50%
LPKRVLIREVGPRDGLQNESTWLDTSEKQRWIELLTAARLPYIEVTSfvhPKWVPalKDAKELAQSLHKKGDITYAALIP-NEKGLAHFFEANLDTGA----MFISSSETHNKKNMNQSIQETLPVIKQMTADLKAAGKHTRayistvFGCPYEHQVPMDQVLRLTEMLLSYGIDEISLGDTIGEAHPLQVERRLDILLERFPAD---KIALHFHDTKGMGLANIYTALKAGITIFDASSGGLGgcpyapGSSGNVATEDVVHML----QKLGIDTNINFPALIKAAEWIE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1D9E0(1-292:306) Hydroxymethylglutaryl-CoA lyase n=9 Tax=cellular organisms RepID=C1D9E0_LARHH  E=3e-50 s/c=0.69 id=22% cov=50%
------------RDGLQNESRSLPVGLRVELVERLVAAGLSVIEAGsfvSPKWVPQMAgtAEVLAGIAPAPGLRLPVLVPNR-----QGLQAAMDAGVREIAVFTAASETFAFKNLNCSIGDSLVRFAPVIDEARLAGLRVRGYVSCVLGCPyegsvaPERVVDVSASLLKLGCDEISLGDTIGAGTPDTTRRLIRELAREVPVER---LAGHFHDTWGMAAANVYAAWLEGMRTFDCSVGGLGgcpyapGATGNVATED----LVHLFDGMGITTGVSLAAVVETAHWISRQLGRQPASRAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C30DEA(6-300:310) pyruvate carboxyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C30DEA  E=1e-49 s/c=0.68 id=22% cov=50%
LPARVHVREVGPRDGFQNEPETIATADKVALVNALARTGLSRLEVTSFVradVIPQLADAVELLgaIDVPDHVSVSVLVPNARG-LDAALE--VRDRFDEVNVFLSASESHNRANVNRSVAESLDGIGRVAERARAAGLRCQgtistaFGCPYEGRVPVERALEIARALHDLGCEEVGFGDTTGMANPVQVRAFFARATAEL--GEQVELTAHFHNTRGQGLANVLAALDAGCRSFESSFGELGGcpqsgpthpATGNIASEDLVSML----HEMGVETGIDLAALIGASR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9L429(5-274:301) Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L429_THERP  E=2e-48 s/c=0.73 id=24% cov=43%
-PERVRLVEVGPRDGLQNEAFSVPTDIKIAFIDALSQAGFPAIECTsfvSPRAVPQlaDAEEVMRRIARRPGTRYLALVPN-----ERGLERALAAGCDALALFAAATDAFSQANIGVSIDESLQRYATVAVRAKAAGcwlrgyVSVAVHCPYTGPVEPQRAVEVARRLAELGCDELAVADTIGKAVPDEVARLLEALLRWLPAER---VAVHLHDTTGRALDNVAVALAYGVRTIDAAVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2F685(27-310:338) Hydroxymethylglutaryl-CoA lyase isoform 1 n=2 Tax=Bombyx mori RepID=Q2F685_BOMMO  E=3e-48 s/c=0.69 id=19% cov=51%
-APEIRIYEVGPRDGLQNESKFVPTDIKVELISKIVAAGIKNVEsasFVSPKWVKQMSDSVDVMknIQRVPGVNYPVLVPNLKG-----YETAKQCNVEEIAIFPAGSEGFSQKNLNCSVEEGLRRFKQVADEAVRDGLRVRGYISCVVGCPYDGpihpknIAKITEQWIAMGCYEVSLGDTMGVGTAGSVRRLLHEI---LTVAKPEQLALHFHDTYGQGLSNLLAGLELGIKTVDSSISGLGgcpyarGASGNLATEDLVYFL----YGLGVNTDVDLVKIIEAGRYISNFLGKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5CLY8(1-289:313) Pyruvate carboxyltransferase n=1 Tax=Variovorax paradoxus S110 RepID=C5CLY8_VARPS  E=4e-48 s/c=0.67 id=27% cov=44%
MSAKeaIHITDVAPRDGLQNQAIRVGTEGKLRLIELLAEAGLRSIEAAsfvSPKAVPQMADAGELLPQV--QARFAALRTSVLVPNLKGLERAHAAGAKEIAVVLSATETMNRKNINMGLDQATEVSEQTIAAARALGLRtrayvaVAFDCPFEGETPLDEVLRLSARMHAAAADEIVIADTIGSASPGQVKERILALRGVVPIER---LAVHLHDTRGMGVANAWAALEAGVRRFDASVGGIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1BAX9(4-298:307) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Rhodococcus RepID=C1BAX9_RHOOB  E=5e-48 s/c=0.66 id=25% cov=41%
-PQRVQIREVGPRDGFQNEPEHIPTDDKVRLINALGRAGFTRIEVASfvrPDVIPQLADGVEVLsrIEVPDETKLMVLVPNSKG-LDNALK--VRDKFHEVAIFVSASETHNKKNVNRTVDETMADNDVMAKRIVAEGLDCAaviatsFGCPFEGKVDLTRVLDLAERFAEAGATEIGFGDTTGMCNPAYASEFFAAALDRLPG---VEVTAHFHNTRGQGLANAYAALEAGC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5BFR7(11-294:314) 3-hydroxy-3-methylglutaryl-CoA lyase n=4 Tax=Bacteria RepID=C5BFR7_EDWI9  E=1e-46 s/c=0.67 id=26% cov=43%
------------RDGLQNISAWIPTPEKLALIDGLMASGLKRIEATSfvhPAAIPqmKDADIVARHAvaqAHSLGVEIAALVPNLKG-----AERALTCGITKVNYVISASPQHNLKNINRTPQASLTELqtlrCALPELEVTLIVATAFGCPFQGAVPIADVAALLRAGREMGISRFTLCDTIGVANPRQTVELLQQLRLALPGLDP---ALHMHNTHGMALANIYAAISQGVTRFESAAGGLGgcpfapGAAGNAATEDLV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0UFP7(3-288:305) Pyruvate carboxyltransferase n=2 Tax=Rhizobiales RepID=B0UFP7_METS4   E=2e-45 s/c=0.65 id=23% cov=46%
------------RDGLQNEARFMPTEDKVRLIEQLAASGLGEIEVTSfthPSWIPNLADA-EEVVRATRHLPVGAFALIPNA---RGMERAQRAGIKGMTFVFSATDSHNRRNLNRSTEESLVEILDLHAAAGADGLRrrislsTVFGCPFEGAVPDERIHAIVARLVAGGCERIGLCDTIGIADPVQVDRLSRGLIARFPG---IVFELHLHNTRGCALANVLAGLQAGIVHFDTAIGGLGgcpyapGATGNAATEDVVSML----EAMGVRTGID---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3WDK2(3-277:302) Pyruvate carboxyltransferase n=6 Tax=Bacteria RepID=C3WDK2_FUSMR   E=3e-45 s/c=0.67 id=24% cov=50%
INNRIEIIEVGPRDGFQSIKEFISTEEKKKIIEGIIESGVKKIQLTsfvSPKHIPQMQDA-EEIAKYFLNKypelEFSALVPNYRG-VKRAYEM----GLRNIAYVISVSEGHNKANVNRSVDESFVELEKILADFPDINITldaaTTFGCPFDGEVSYDKVDSYVKRAYDLGIRTINLCDTIGISNPKQIDELLTILLEKYKD---IEFQVHIHDTRNMGMLNSYIAIKKGIKHVQASLGGMGgcpfapGASGNLSTEDFVYML----DKINIETGINFKKLVNIAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8SJR8(1-248:354) Homocitrate synthase n=1 Tax=Mesorhizobium opportunistum WSM2075 RepID=C8SJR8_9RHIZ  E=5e-44 s/c=0.73 id=35% cov=47%
MSSQVFLKDTTLRDGEQAPGVAFTVAEKLEIAESLAAAGVPEIEIGTPAMGADE-------VARSLSVRLTAWCRMTSPDLEAAIES----GVRAVNLSFSASNIQLATKLGLDRAGALQLIEHMVGRAAASGSSVAVGCEDASRADRDHLGRVIMTAARAGARRVRLADTAGVLDPFSTFELVAQ----------------------------LAAIRAGARHASVTLLGLSERGGNAALEEVAAALAVLQHA---HAGIDLTALPALAAKVAQASRRPTAATKPIVG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001BC53D7(5-315:327) pyruvate carboxyltransferase n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC53D7  E=6e-44 s/c=0.58 id=25% cov=44%
LPKKINIIDITMRDGLQNEEKFLPLEGKLHIAEKLIDAGVKKIEVGSMSHVKyvpqfRDIDDLMRALPKRDDVEYTVLALNKKA-VERVVKLLeEGIKIDRVLTGqLATSEAYAKKNMNRTHEELFLEAEKNVKLLHDAGIKkvvgnigTIFGCPIQGEVPIEKAYEFADRMFQIGFDEIEHSDPDGKATPKDILEYFSVVLEKYPDPSKH--SFHIHDIRGTGIAGYYAAMMAGIINFDCTIGGIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4ELN2(17-293:298) Hydroxymethylglutaryl-CoA lyase (Fragment) n=5 Tax=Proteobacteria RepID=A4ELN2_9RHOB  E=8e-43 s/c=0.64 id=23% cov=39%
----VRIHEVGPRDGLQNEPSVISVARKVALIDLLSQSGLRDIEVGsfvSPKWVPQMADTDQVLAQLSPvqCVRYAVLVPNKRG-WDGFLDARRDDIITDIAVFIAASEGFSQSNLNCSIAESVDRLRPVVAAAKETGVTVRGYVSCVTDCPFDgptspqQVADTVAMLRDLAPMQISLGDTIGQGTPDRISAMLEAVLAVAPATD---LAGHFHDTGGQALAN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C3228C(14-294:317) pyruvate carboxyltransferase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3228C  E=9e-43 s/c=0.63 id=22% cov=48%
------------RDGLQNHPTLLGVRDRIELVERLSRTGVPRLETTS-FVNERRVPAMAGADEVAKGlARSPGLRRAALVLNERGYERLAAADLDEVHVAFAASEELNRRNQNASPAQSCAAALAIVERAHADGrsasvtIAAAFGCPFEGVVDPGVVLDYAARVIDGGADEVVFADTIGVGVPAQVRRLVAGGRAC-----GGRVGVHLHNTRNTGYANAYAALEAGAQLLDASIGGLGgcpfspGATGNIATEDLVYLL----HGEGVSTGIDLDALIEVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0CZY8(5-277:300) Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CZY8_9CLOT  E=1e-42 s/c=0.64 id=23% cov=48%
------------RDGFQNVKEFIPTQEKLQIIDGLVEAGFKKIQITsfvSPKAIPQMRDAAELsevVLSKYKSLQVFALVPNFYG-----ARLAVETGIQELTPVISLSESHNMANVKRTVNESVEEIKQIRQTFPDIritqDIACVFGCPFEGEMQVEALLELVGKLREIGVDAFTLCDTVGVAYPTLIERVFRAVKTQFPG---VEFNAHIHDTRNMGTLNSYVALLSGAYSVQTAVGGLGgcpfapGATGNTSSEDLIYMLN----HCGYDTGINFETLLRTARF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1B6M4(44-317:507) Pyruvate carboxylase n=2 Tax=Synergistaceae RepID=D1B6M4_THEAS   E=6e-42 s/c=0.64 id=23% cov=41%
-PRRIGITETAFRDAHQSImATRLRTEDMIPIAEAMDQVGYHSMEVWggatfdacMRFLDEDPWERLRELRRRMPNTKLQMLLRGQnlvgyrhyaDDVVREFVKRAVGNGIDIIRIFDALNDLRNMEVA----ADQVKREGAHLQLAISYTISPVHTLESF--------VKQAEDMVSMGADSICIKDMAGLLSPTEAGKLVSAIKSRI---GRVPLQVHSHYTSGFAAMTYLASIMAGADVVDCAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8ZRW8(25-299:681) Conserved carboxylase region n=6 Tax=Bacteria RepID=A8ZRW8_DESOH   E=9e-41 s/c=0.62 id=23% cov=44%
------IMDLSLRDGHQSLfATRGRTEDMLPVAGLMDEVGFWAVEVWggatfdtmHRFLNEDPWERIRTLKRYFKKTPLSMLLRGQnlvgyrnyaDDVARAFVERAAENGMDVFRTFDALNDFRN-----------FETVVEVIKKCGKHFQGTICYSMTEPRlggevYNVEYFVTKAKELESMGADTICIKDMAGLVAPYDIFNVVKALKESV----KPPIHFHSHFTSGLAPMSHLKAVEAGVDILDTCLSPYAYRTSHPAVEPMVMSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2RIA5(28-299:643) Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=15 Tax=Bacteria RepID=Q2RIA5_MOOTA  E=2e-40 s/c=0.62 id=24% cov=39%
---QLKITDTTLRDGHQSLwATRMTTADMLPIIEKIDSVGYHSLEVWggatfdvcMRFLDEDPWERLRTLKKYARRTPLQMLLRAQslvgyqlypDDVVRAFIARAAANGIDIIRIFDALNDLRNMEV--------------PVEAAKKEGVHVQGTV-VYTISPVhttEHYLKTALELESMGVDSICIKDMAGLLAPFEAYKLVKLFKEKLH----VPVQLHSHYIGGLAVGAYLEAARAGVDVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9F132(3-289:305) Putative uncharacterized protein xlnI n=1 Tax=Pseudomonas alcaligenes RepID=Q9F132_PSEAC  E=2e-40 s/c=0.59 id=20% cov=49%
------------RDGFQSICEPIETQKKISIIEDLVSAGCKRVEIGSfvnPKAVPQMADtsLIAQHFGGRKDFRALALVPNLKG-----FERALENDVKEMAYVFSASDTHNQKNVGCSTKDSIEALKVLIKTYhseKDISLRVsigtAFDCPYQGRILLDRLRSVVSEVLETSDDvEIALCDTTGRATPFQVENAFLEFIKE-NEARSTRWAFHGHDTYGLGIANAFFAYRSGVRIFDSSAGGLGgcpfapGASGNIATED----LVYSFEKSGIKTGVEFKSLLDVADVISEL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1WMV8(4-300:314) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Proteobacteria RepID=A1WMV8_VEREI  E=2e-39 s/c=0.56 id=21% cov=52%
LPRRVHLHEEGPREGFQMEAGPIASADKVRLIEALARTGLREIQCVSfvnPGRVPGmaDAELVAQSIRKRQGVRYTGLWLNLRG-----MQRALGTPLDIEGTVsISASEAFSVRNYGKGTAALLDAQRTTLAFCVEHAIAVtrasvttAFGCNLEGaicaATVVERVSQLLGLMDEFGlpLPILRLADTVGWAQPNAIASAIGAVRERWPALR---LGLHLHDTRGTAMANALMGLQMGIDTFDSACAGLGgcpfaghtGAAGNICTED----LAFMCEEMGIDTGVDLEALIECARLAEQIVGHPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IRS1(1-289:290) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Candidatus Koribacter versatilis Ellin345 RepID=Q1IRS1_ACIBL  E=8e-38 s/c=0.56 id=21% cov=43%
MADTVKIIEC-PRDAWQGLKGQIPTELKVKYLQELVSAGFKHIDAvsfVSPRAVPQMADSEEVLKELdpPDDVEIIGIVVNEKG----ADRAIATEAVRTLGFPYSFSPTFLKNNQNQTLEENAEVLEKVVEKQRSADMDLVVYISMAFGNPygdlwsVDEVLEGIGILADDGIQQISLADTVGLATPQQIADLCGPIVEKF---DYLEVGVHLHGTHTDAKEKVLAAYDAGIRRFDAALGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4XM98(43-327:331) Pyruvate carboxyltransferase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XM98_CALS8  E=4e-36 s/c=0.54 id=22% cov=51%
IPSKLYVTDSTFREGQQAIS-YIGKENVAKIFEYLhyVDNGtgtIKYSE--FFLYTNYHKQCVQEcLKKRFKFPKVVGWVRSKKDELKLAKEF----GLDEVGILMSCSDYHIYKKFQKTRSEIAARYIDIIQEAFSLGITPRVHLEDITRSDIEnFVIPLILAIEEMAKKCdkkvyFKLCDTLGFGVPYEYASLPRSVPKLIytisksTDVPPERLEWHGHNDFYKAQSNAVCAWLYGASMVNCSIRGIGERTGIAALEVAILDLVQIKDEN--APNLNFEALDELLEFTSRF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5KC29(2-260:830) AMP-binding enzyme domain protein n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KC29_9RHOB  E=6e-36 s/c=0.60 id=22% cov=42%
------ILDTTLRDGSYVNNFSFTLDETRFFTRELSRLGLELIEVGHGIglgatekgispAVETDQDYMKAAALAVEesgsqKAKWGMFCIPGIAELNH-IDLAHDHNMGFIRIGVTVED--------------INLARSFVEKSKKLGLYVCVNFMKSYTSSPQEFSAAVAQAASFGADIAYLVDSAGTMVPADVEDYFRTVRRN----SILPLGFHGHNNLGLANINAYTAYNEGAGIVDVSMQGMGRCTGNTSTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1K893(7-276:346) 4-hydroxy-2-oxovalerate aldolase 3 n=20 Tax=Proteobacteria RepID=HOA3_AZOSB  E=5e-35 s/c=0.56 id=25% cov=49%
---RITVHDMTLRDGMHPKRHLMTLEQMKTIAQGLDQAGIPLIEVthgdglggssvnyGFPAH--TDEEYLGAVIPLMKQAKVSALLLPGIGTVDH-LKMAHELGVNTIRV-----------ATHCTEADVSE---QHIRYARKLGMDTVGFLMMAHMNSPEGLVQQAKLMESYGANCIYVTDSAGHLLPDTVKARIGAVRAALK--PETELGFHGHHNLAMGVANSIAAIEAGATRIDAAAAGLGAGAGNTPMEVLIAV----CDLMGIETGVDVFKIQDVAEdLVVPIMDFPI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q49WN9(533-807:1151) Pyruvate carboxylase n=48 Tax=Bacteria RepID=Q49WN9_STAS1   E=2e-34 s/c=0.55 id=21% cov=40%
----VLITDTTFRDAHQSlLATRVRTKDMMNIASKtaqvmkdsfsLEMWGGATFDVAYNFLKENPWKRLERLRKEIPNVLFQMLLRAsnavgykNYPDnvIKKFVKESSEAGIDVFRIFDSLNWVDQMKVAN----EAVQEAGKISEGTICYTGDI-LNPNRSDIYTLQYYVDMAKTLEREGFHILAIKDMAGLLKPKAANELIGELKAAV----DLPIHLHTHDTSGNGLLVYKQAIDAGVD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0YUR2(2-257:282) Hydroxymethylglutaryl-CoA lyase like protein n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YUR2_9FLAO  E=2e-34 s/c=0.58 id=19% cov=42%
------------RDAMQGWGEFIPTDKKIDYINSLMDVGFDVLDClsfVSPKAIPQMADS-NEVAENIDKSRSKTKVSAIIGNYRGAEKALKHQSVDILGFPFSISETFQHRNTNKSQEEAFDEIIKMLDLVKSEGKQLNIYFSMAFGNPYgemwkwEDVDQWAQRFSDIGVKDILLSDTTGVATPETIALLFEKIPSKYPE---INFGGHFHNRYEDSYSKLKAAYDKGCRRFDSAIKGIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000187E0D5(16-347:349) hypothetical protein MPER_06159 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187E0D5  E=5e-34 s/c=0.45 id=23% cov=41%
--------------------------------------------------------------------------------------------------------------------------------------------ETFSQTEPEFAVELANKVLAEWGKAtpedkiyFNVAATVECAPSNHYADLIEYFSTNINQRDAAVISIHPHNDRddltssneGTAVAAAELGLLAGGDRIEGCLLGNGERTGNGVLLVWI-----------------LSILRKIVQGVCRCNESAVPVRYPYAGTLVFSAFAGTHQDAIKKgldaqDKRWadvdrtgkgtkywampYIPLDPKDLGYGyENLIRVSSQSGKAGTAYVVKQtLQFDIPRRMQVAFYGVVQSECEKSG-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1BM26(530-798:1148) Pyruvate carboxylase n=33 Tax=Bacteria RepID=D1BM26_VEIPT   E=8e-34 s/c=0.55 id=23% cov=37%
--KQVFFTDTTWRDAHQSLfATRLRTIDMARVAGHaakgvpnlfsLECWGGATFDVSYRFLHEDPWERLRMFRREVPNTLLQMLLRGAnavgytsypDNVVRQFIQRATANGIDVFRVFDSLNSL---DNMHVAIDEVRAQ-NKIAEVALCYTGDILDGA--RTKYNLDYYVNMAKELEKAGANIIAIKDMAGLLKPQASYNLVSALKDAV----SVPIHLHTH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q039M6(527-790:1145) Pyruvate carboxylase n=9 Tax=Lactobacillaceae RepID=Q039M6_LACC3   E=2e-32 s/c=0.54 id=21% cov=41%
---QLLLTDTTFRDAHQSLfATRMRTRDMLTVAQdmgnglpnlfSMEVWGGATFDVAYRFLNEDPWTRLKKLRAALPHTLLQMLFRGsnavgyqNYPDnvIKAFIQKAADDGVDVFRIFDSLNWLP-----QMTL--SIDTVKQTGKLAEATMCYTGDILSHAHpKYQLAYYVDLAKQLVAAGADMLAIKDMAGLLKPQAATELVTALKDAV----SVPIHLHTHDTTGNGIATYVAAANAGVDIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0QL23(13-335:377) HmgL n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QL23_DESAH   E=7e-32 s/c=0.44 id=23% cov=44%
MPKKVTIGDITVRDGFQHEEKFISTEAKKFYLEELIFAGCRHIEVtnlGNPYLMPQfrDAEELltylkgdlfkKKCTKRGIDTNDISLTciTIREPAVDRAIELKKqGIGPDRILMMVSTEEQHHFANSGTTLPNYWKEAERSIKKCNDAGIKMCgtvstiWGSPIGGATDMRDAVKFAKRWLDIGAHDVEHADHDGSASAAQVYRYFSMVLDALPDPRLHI--AHFHETKRMASASILACLQAGIINFEATLGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q46S19(549-826:1169) Pyruvate carboxylase n=102 Tax=Bacteria RepID=Q46S19_RALEJ   E=2e-31 s/c=0.50 id=24% cov=41%
--KRVLLTDTTMRDAHQSLfATRMRTADMLPIAPfyarelpqlfSMECWGGATFDVALRFLKEDPWQRLEQLRERVPNILFQMLLRGSnavgytnyaDNVVKFFVRQAASAGVDVFRVFDSLNWVR---NMRVAIDAVGES-GALCEGAICYTGDVF----DGSRpkYDLKYYVGIARELKQAGVHVLGIKDMAGICRPQAAAAL----VKALKEETGLPVHFHTHDTSGISAASALAAIEAGCDAVDGAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5S7B1(13-259:327) Pyruvate carboxyltransferase n=2 Tax=Bacteria RepID=C5S7B1_CHRVI   E=2e-30 s/c=0.55 id=22% cov=44%
------VLDCTVRDGGLVNAHQFSDDFVRAVYRACVEAGIDYMEIGYknsPKVFPKEKFGPWRHCDEADLKRVVGDHDPEKTGLKLAAMAdAGKSDWETQIVPAAESPLSMIRV--AFYAHQVSEAVDMIRYAHDLGYETTANLMAVSNITEAEIDTVLESIAPTPATTMVIVDSFGYLYREQIDRLYRKYTSAL-EGTGKEIGIHAHNNLQLAFANTIEAIILGCNRVDATMYGFGRGAGNC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B3E4J8(2-271:531) Pyruvate carboxyltransferase n=1 Tax=Geobacter lovleyi SZ RepID=B3E4J8_GEOLS  E=1e-28 s/c=0.48 id=20% cov=44%
--KSIQILDCTLRDGGFVNDWNFGLGSMKSIISRLDKAGVDMVEIGFIderrsydpnRAIQPDTQSFQAVLQglDIRNSLILGMVDYGTCDIDKIAPKEHSY-IDGIRVIFKKKDQ--------------DAALRYLQQIKAKGYKIYVNPVSITGYSDEEICSLIGKINGLDPEGVSIVDTYGLMHRKDLLHYFRLFDKYLSN--HITLGYHAHNNFQLVYANSIELCElLGERniIIDSSLYGMGKGAGNANTELIAM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4JI85(544-789:1131) Pyruvate carboxylase n=1 Tax=Uncinocarpus reesii 1704 RepID=C4JI85_UNCRE  E=4e-28 s/c=0.52 id=23% cov=38%
--RKTLITDTTWRDGQQSlLATRVRSKDLDAIAKHVSYA----------------YQAAYSL-ECWGGATFDVMLRFLLPDNALfhFVKLAKDTGVDIFRVFDSLNDL---ENLKVGI-EAVHAAGGLVEGAVMYTGDM---LEPGNKYNLEYYLGIVDRLVEYGSHVIAIKSMSGVMKPAAGRALVKAIRLRYPD---IPIHMHTHDTNGTGTATMLACVEEGADIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3ASA1(2-277:650) Oxaloacetate decarboxylase, alpha subunit n=35 Tax=Bacteria RepID=Q3ASA1_CHLCH  E=1e-27 s/c=0.46 id=21% cov=41%
--KKIRFMDVSFRDGFQScYGARVRTEDFLPVLEAAVAAGTDNFEIGGGARFqslyfyceEDAFEMMDRAREVVgpdinlqtlsRGANVVGLISQSRDIIDLHARLFKKHGISTIRNFDALMDVRNLAYSGQCIHNAgLKHQVVIALMGLAPGLK-ETYC-----HTPQFYLDKLQEILDTGIpfDSVAFKDASGTTTPATVYETVKGARKMLPSET--VIEFHTHDTAGMGVACNFAAIEAGADII----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0ANI5(3-248:527) Predicted protein n=1 Tax=Enterococcus faecium C68 RepID=D0ANI5_ENTFC  E=6e-27 s/c=0.50 id=17% cov=38%
----VQILDCTLRDGGYCNNWEFGFDNTKKIISGLIESGIEIIECGFLTNktvynkNVTKYTTLEELAQIIPEKREGKLFVAMMNYGEYNIEDLPD--------YDGSSIDGIRIAFHK---KNCNEALKLCREIKKKGYLVFVQAMVSLNYTDEEFLAVIKNVNQFKPYAFYIVDSFGMMKGKDLTRLFYMIEHNL--EKDIQIGFHSHNNMQLAYSNA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6L7H4(1-249:525) Putative 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Bacteroides vulgatus ATCC 8482 RepID=A6L7H4_BACV8  E=6e-27 s/c=0.50 id=20% cov=44%
MS-KIQLLDCTLRDGGYINNFRFGKYAIRKILQQLTHAGLDIVECGFLEDGEYDedtsiFNAAEQIASLLPNEHGRTMFVAMVCYGEYDLSQLSPCTRNSID--------GIRVTFHYDE---VEGALEYCREIKEKGYKVFVQPVGTSSYTDIQLLHLIEKVNELQPYSFYLVDTLGLMHKNDIARFFYLINTNLDK--SINMGFHSHNNLQLSFSNSQEFFEYVGDRVislDASIYGMGRGAGNLNTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3PVE7(2-257:528) Pyruvate carboxyltransferase n=2 Tax=Bacteroides RepID=C3PVE7_9BACE   E=7e-27 s/c=0.48 id=19% cov=45%
-------LDCTLRDGGYVNDWDFGHSTITGIYKRLEAAGADYIEVGF-LDDRREFDINRSIMPSTE-AINKIFGSVKKgKAIPVAMIDFGTCSLDSIGSCDSTFIDGIRVIFKK---EKIDQALPFCKAIKEKGYKLFIQAISITAYSDIEMLEYVNRINEIKPYAFSIVDTYGLLDNSSMARYFYLIDNNLD--PSIKMGYHEHNNFQLGFSNTIKFLEKSTKRtlvADSTVYGMGKSAGNCASELLAMHLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6LFD8(1-288:641) Pyruvate carboxylase subunit B n=42 Tax=Bacteroidales RepID=A6LFD8_PARD8  E=8e-25 s/c=0.41 id=20% cov=44%
MKREIK-FSLVFRDMWQSAGKYVPTvDQLTRVAPAIIEMGcFARVEtngGGFEQVNllfgENPNKAVREWTKPFHAAGIQthMLDRALnglrmspvPDDVRQLFYKVKKAqGTDIARTFCGLNDVRN--------------IAPSIKYAKEAGMISQCSL-CITHSPvhtVEYYTKMAFELIELGADEICIKDMAGIGRPYTLGRIVANIKEKYPE---IPIQYHSHAGPGFNVASIMEVCNAGCDYIDVGMEPLSWGTGHADLLTVQAMLK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7ANX1(2-266:538) Putative uncharacterized protein n=2 Tax=Bacteria RepID=B7ANX1_9BACE  E=1e-23 s/c=0.43 id=23% cov=44%
--KNISILDCTLRDGGRVINCEFSDDEIRDISRRLSDSNIDIVEVGFLRDSKKvhfegnstFFTDVNQIAPYLDkssgNCMYVAFIDYGMFDFD-TLGQCDGTSVDGIRV------GFTKKDYYSSRDDIIRCLN--IVKARGYKLFVQ-GVNSLSYSDKEML-DLVDLVNEVHPYSFGIVDTYGAMYEDDLQRIYALINNNMHK--DICIDFHSHNNYQlsFSLAQSIIRLSDSVRHiiIDATLNGMGKVAGNLNTELIV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4AUD2(409-598:598) Threonine synthase, putative n=23 Tax=Francisella RepID=B4AUD2_FRANO  E=1e-23 s/c=0.59 id=25% cov=20%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKSFKVKVELDQKSVAEVTVKVAEQLYFASSSGVGPVDAVLNALCKACPSDIsyNLTDYKVKIRGQGADAVVYVEMSLEKEGIKSIGKAVSPDIIQASVEAFIDAYN--------------------------
>UniRef50_UPI0001B521AE(10-194:233) 2-isopropylmalate synthase n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B521AE  E=9e-19 s/c=0.53 id=26% cov=33%
--------------------------------------------------------------------------------------------------------------------ETSDAAARLVRYARSLGLDVIVPLLMVSYLTEDAHEEAVTVLTGAGATELTLFDGPGAMSPEAYAPLVHRTRTLAPD---VEVGLHPHNTFGLAVACAVAAVRAGATAVELSVNGYCGGPGNADLAATALAFEA---LYGIHTGISTELLTGLARSGQELTGYRTAWNHPVTGTHAF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0RGT1(1-167:240) Putative aldolase n=1 Tax=Frankia alni ACN14a RepID=Q0RGT1_FRAAA   E=5e-14 s/c=0.49 id=32% cov=21%
-----------------------------------------------------------------------------------------------------------------------------------------------SRADPARLALAVSRAAQAGAGLVYLADSNGSLYPEDVTRRVSaAVHAATEQGPGPVIGFHAHDNLGLAFANSCAALDAGATALDASIGGIGKGGGNLRLELIAAHLTLH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2VDA7(1-522:522) 2-isopropylmalate synthase n=4 Tax=Enterobacteriaceae RepID=LEU1_ERWT9  E=1e-172 s/c=1.16 id=82% cov=100%
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQIKNSRVCGLARCVEKDIDAAYEALRVADAYRIHTFLATSPMHIATKLRSTLPEVIERAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTINIPDTVGYTLPYEYANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEGAMNGLGERAGNCALEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAIIGSNAFAHSSGIHQDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGYGETEYNMDRLYDAFKALADKKGQVFDYDLEALAFINQQSEEPEYFRLDTFNVQSGSSVIATATVQLRCGDEQKTEAATGNGPVDAVYQAINRLTEFDAELVSYQLTAKGHGKDALGQVDIVVQYNGRKFHGVGLATDIVESSAKAMVNALNTIWRARQVEQELQRKSQ-VKDQKETV
>UniRef50_Q3AEQ5(2-509:509) 2-isopropylmalate synthase n=42 Tax=Bacteria RepID=LEU1_CARHZ   E=1e-160 s/c=1.12 id=53% cov=97%
--ERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPGDKEAVSLIAREVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVERAVAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPEEFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGNCSLEEIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESGIHQDGVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFVKFKALADKKKEVTDQDLEAMM-EEEIRKVPETYTLDYFHISTGSTIIPTATVGLIKEGEKLEDAATGDGPVDAIYKAINKITGLTPVLEQYSINAVTSGEDALGEVVVKLKNGlGKIVTGRGVSTDILEASAKAYLNGINKLLFDYQAKGEKQ-------------
>UniRef50_A3PDH0(1-539:546) 2-isopropylmalate synthase n=42 Tax=cellular organisms RepID=LEU1_PROM0  E=1e-157 s/c=1.03 id=46% cov=100%
MSKnpgRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIASAVgkeHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFfkrnpdsptplTAIRTEEITKTSRLVSNLTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSE-QVQLPEAKFQLSLVQVSCGNASKPTATISLLNTEDNTEDTAVsiGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYINALNRLVFSEKKN-SIHPQFDNLENSNNT-
>UniRef50_A4YZ76(10-510:525) 2-isopropylmalate synthase n=131 Tax=root RepID=LEU1_BRASO   E=1e-155 s/c=1.10 id=46% cov=96%
--DRVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDGDFEAVNEIAKRSKNAVICGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVFELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGYAVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVEDAFVRFKALADRKKQIYDEDIEALIDEGMVSA-HDRIKLLSLSVIAGTRGPQRATMKLDIDGVTRIEESEGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADPDTLVASAKAYLGALNKLVMKRQ-------------------
>UniRef50_B6YRN0(11-501:504) 2-isopropylmalate synthase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRN0_AZOPC  E=1e-144 s/c=1.04 id=49% cov=94%
----VFIFDTTLRDGEQVPGCQLNTIEKIQVAQSLESLGVDIIEAGFPISSPGDFNSVIEISKSVTWTIICALTRAIEKDIDIAAESLQYAKRKRIHTGIGTSPYHIKYKFNSTQDEILERAVASVKYAKKYVEDIEFYCEDAGRTDNVYLARIVEAVIKAGAKVVNIPDTTGYCLPEEYGAKIKFLMDNVKGIQNVILSTHCHNDLGMATANTISGIINGARQVEVTINGIGERAGNTSLEEVVMIIKSHKE-LNIGTNINTKHIYPISRMISSLMNMPVQPNKAIVGRNAFAHSSGIHQDGILKNRENYEIIDPKDIGIDNNIIALTARSGRAALKYRLNILGIELSQKKLDDIYEEFLKLADYKKNINDDDI--LMLAGKDRTESNRIRLEYLQVTSGVGILPVASICLNIAGEKFEAAASGNGPVDAAIRAVKQIIHRQMVIQEFLIQAINKGSNDVGKVHMQVKYNDVNYYGFAANTDIVAASVEAFIDAINK-------------------------
>UniRef50_Q58787(3-490:491) (R)-citramalate synthase n=5 Tax=Methanococcales RepID=CIMA_METJA   E=1e-143 s/c=1.05 id=38% cov=93%
----VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKEGLNAEICSFVRALPVDIDAALE----CDVDSVHLVVPTSPIHMKYKLRKTEDEVLETALKAVEYAKEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQKSQELFKKITENV----NLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLEEVVAALKI---LYGYDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGLIKNTETYEPIKPEMVG-NRRRIILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVKEFGDLGKYISDADLLAIVREVTGKLVEEKIKLDELTVVSGNKITPIASVKLHYKGEDITliETAYGVGPVDAAINAVRKAISgvADIKLVEYRVEAIGGGTDALIEVVVKLRKGTEIVEVRKSDADIIRASVDAVMEGINMLL-----------------------
>UniRef50_O26819(2-493:496) (R)-citramalate synthase n=20 Tax=Archaea RepID=CIMA_METTH   E=1e-136 s/c=0.99 id=38% cov=94%
---QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITSEGLRAEICSFARAVREDIDAAI----SCDVDSVHLVVPTSDLHLEHKLRKTREEVLEQAVDCTEYAVDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVGILTPERSYEFYRGLSEL-----GAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNAALEEVVVALKSLYD---VDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHADGVLKKAETYEPITPEMVGHGRG-FVMGKHIGTHALRKRLDELGMKVADDKLMEIFRRVKTLGDMGKCVTDVDLQAIAEDVLGVMEDKVVDLQEVTIVSGNRVTPTASVKLRVDDREVLEAGTGVGPVDAAIVAIKKSLEdfADITLEEYHVDAITGGTDALIDVVIKLRHGDRIISARSTQPDIIMASVEAFLSGVNRLLANEKSE-----------------
>UniRef50_A6VFV4(2-492:492) Isopropylmalate/citramalate/homocitrate synthase n=7 Tax=Methanococcales RepID=A6VFV4_METM7  E=1e-135 s/c=0.99 id=35% cov=93%
----VNIFDTTLRDGEQTPGVSLSPSEKLEIAIKLDELGVNIIEAGSAITSKGEREAIKLVAEQKLNAEISSFVRALPVDIDAAL----SCNVDSVHLVVPTSDLHMEYKLRKTREENLKDAMHAVDYAKEHGLIVELSAEDATRSDVEFLKELFKKGEELKADRICLCDTVGILTPVKSMELIKTMKAAVT----IPISIHCHNDFGMATANTLSAISAGADQCHVTINGIGERAGNASLEEVVMSLKSLYD---METNIQTEKLYKISRIVSKYMKLSVPANKALVGDNAFAHEAGIHVDGLMKSTETYEPIGPEVVG-NRRKIILGKHSGKAALKYKLELMNIGLSHEQFEEVYSKIKAFGDLGKYISDVDLKTVISQVQGVELERKVILDEITVMSGNKVSPLASINLKFAndcniKDNIREAAYGLGPVDAAINAVKKALTgvADIELEDYSVRAMTGGTDALIEVVVHLRKGNEVVEVRKAHGDVVMASVEAMMDGINLLI-----------------------
>UniRef50_C6CVJ5(2-485:513) 2-isopropylmalate synthase n=2 Tax=Bacillales RepID=C6CVJ5_PAESJ   E=1e-132 s/c=0.98 id=41% cov=92%
--KKIQIFDTTLRDGEQSPGASIEPERKIIIARQLAKLGVDIIEPGFAISSPGEFAAIQQISRELQNVEICGFARAVKVDIDAAVKATQDAAKRRLHLFISSSDIHLSHQIRKTRSEVVQIARDMISYAKQFVDEIQFAAMDSTRSDRDFVIELVEAAIESGATIINLPDTLGYALPNEMVDLFTSVRQQARGGDKVRYSTHNHNDLGMAVANSLAAVQAGATQVEVTVNGVGERAGNCSLEELAMLIETRKSALEIETNIEQSEIYTTSHMVSRAMHYPIAYNKPIVGRNAFQHESGIHQDGLLKDRSTYEIMDPEAMGISRSMIILGRHSGRHAIKHRLSEYGIAVADNELNDVYDKFKQVADEKKIVTDDELIRIAGEATET-QPDPYKLMDLQVLAGSQKSRIASVTIRDGEDggERSYSGMGEGPLEAVIHCIQQAIPVAAQFEDLELHSLSTGEDAHGEAVVSIVIEGERFRGTSIHKDII--------------------------------------
>UniRef50_Q0AT07(14-511:529) 2-isopropylmalate synthase n=3 Tax=Alphaproteobacteria RepID=Q0AT07_MARMM  E=1e-127 s/c=0.92 id=40% cov=95%
-PDRLRIFDTTLRDGEQAPGFSMNPAEKLEIARLLEAMRVDTIEAGFAAASPGDSEAIRLIASEIRNSTLCSLARATEGDIDAAAKALEPAHRKRLHIFLATSPIHREAKLRMSRREVLQTIERCLKHAAGTFDEIEFSAEDALRTEPDFLVEAMSCAAVNGADVLNVPDTVGYSEPDEIRAVFERLAAHVERPDHVIFSAHCHNDLGLAVSNSLAAVKGGARQVECAINGIGERAGNCSLEEIVMALQVRADIFPAISHVDATKIWSASQRLARVTGSAVAPNKAIVGKNAFAHEAGIHQHGMISDRRTYEIMTPESVGAPGSALVLGKHSGKHALVQRLAKLGYQPDPDKLNQVFKDFKHLADELGEVNDADLVAMMEGFSASGSRWTVLRTELRTTAGRQPKQFARVELEHPDRgRVSDIASGDGPIAAAFAAVQRITGTDATVtaLETRMRSTATGREFVADISIDI--DGTIFSGRARGPDIVTAAIDSLLFTLDR-------------------------
>UniRef50_A8L551(33-560:565) 2-isopropylmalate synthase n=38 Tax=Bacteria RepID=LEU1_FRASN   E=1e-116 s/c=0.80 id=26% cov=94%
ITEAPRWCSVDLRDGNQALIDPMTPSRKMQLFELLVAMGYKEIEVGFPAASQTDFDFVRQLIEDdliPDDVTIQVLTQAREELIERTVTSLVGSDRALIHLYNSTSTLQRRVVFGLDRAGVTDIAVQGARWCAQYaeklleGTDVRwqYSPESFTGTELDYALEVCEAVMDVWAPTpdnpvvLNLPATVEMSTPNVYADQIEWMSRNLTRRDAVVLSLHPHNDRGCAVAAAELGVMAGADRVEGCLFGNGERTGNVCLVTLGMNLFSQ----GIDPMIDLSDIDGVRRTVEYCNQLPVHPRHPYGGDLVYTAFSGSHQDAIKKGFEamertgqtlwevPYLPIDPKDVGRSyEAVIRVNSQSGKGGVAYLMKsEYALDLPRRLQIEFSGVVQKHTDDaGGEVTAGQLWEIFTREYRPEGGDPaasLELLGSRTTAASGARDEVTVSVRLDGTETVITGSGNGPIDAFVAALSE-RGVPVRVLDYNEHALGSGADARAAAYLEVAVGETVLWGVGIDPNIVTASLRAVVSAVNR-------------------------
>UniRef50_P06208(57-600:619) 2-isopropylmalate synthase n=109 Tax=cellular organisms RepID=LEU1_YEAST  E=1e-114 s/c=0.76 id=25% cov=96%
ITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAPdDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDdpsqqatrwsYEFSPECFSDTPGEFAVEICEAVKKAWEPteenpiIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQ----GVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYGGDLVVCAFSGSHQDAIKKGfnlqnkkraqgetqwRIPYLPLDPKDIGRDyEAVIRVNSQSGKGGAAWvILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNyndEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVRFAVANYTEHSLGSGSSTQAASYIHLSyrrnaDNEKAYkWGVGVSEDVGDSSVRAIFATINNIIHSGDV------------------
>UniRef50_C6PDK4(4-383:397) Pyruvate carboxyltransferase n=1 Tax=Thermoanaerobacterium thermosaccharolyticum DSM 571 RepID=C6PDK4_CLOTS  E=1e-113 s/c=1.09 id=45% cov=73%
--RKVIVFDTTLRDGEQTPGVNFDKDSKYRIAKQLVSLGVDVIEAGFPAASNGNFEAVKHIAENIDDVVVAGLSRCVKSDIDKTYEALKNAKKSRIHLFIATSDIHLKYKLKISRDEALKMAVDSVKYASGKFDEIQFSAEDASRTDWDFLVKIFNEVVDAGAKIINIPDTVGYAVPKEFEKLVEYVKKHIHDKDNVTISVHCHNDLGMAVVNSLSALENGADQVEVTVCGIGERAGNASLEEVIMAINTRKDYFNLLHSINTREIFSTCKLVSELSGIDLQPNKAIVGSNAFRHTAGIHQHGVINNKATYEIMRPEDIGITTDHISMGKLSGRNAFELKLKNMGYELSRDEMNLAFKKFKDVADNKKIVNDNEIKAIVDDV---------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B3TC58(9-521:530) Putative HMGL-like protein n=1 Tax=uncultured marine microorganism HF4000_APKG10H11 RepID=B3TC58_9ZZZZ  E=1e-113 s/c=0.81 id=26% cov=93%
----IEILDTTLRDGSQMRGVNFTLQEKIMIATKLDDLGVNIIEGGWPGSNPKDLEFFKLIKKhELRNSKIAVFGSTRRKNItaknDNNLKVMVDSEALVSVIVGKTSSFHVEKILNCSLEDNLEMIYDSLIFLRESGLQTYFDAEhffDGYNINPEYAIQTVKTAEEAKVNTIVLCDTNGGMLPHQIERVVKKIKKN----SEVKIGFHGHNDTGCAVANTVSAVVAGATHIQGTINGLGERTGNADLCQVIPNLEMKLKKKtrniQKKQIINFGKLRDISNYINELVNINSFDHQPYFGKFAFSHKAGLHVDGMLKSSKAYEHINPEIF-KSERSFTISELSGKANIIALSKKFNfqIDKDDKRIIDILEEIKKL-EFSGFTLDnaDATTYLIFLRHLGLYKQYFHVDSWKVLTEkqNQINSKSEIKILIGENIYTNNAYGVGPVNSLAIALRKSLQnkypeiNKIELTNYKVSIVGASKDtaSLVRVFIEFKKDEVVWATTATSQNILDASLRALIDG----------------------------
>UniRef50_C8WRC1(29-553:564) 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=C8WRC1_ALIAD   E=1e-113 s/c=0.78 id=25% cov=94%
-----IWCSVDLRDGNQALIVPMNLEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTLIERdlvPSDVTIQVLTQSRDHIIERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIVNIAVTGAEQIRDLARTTpgnfffQYSPESFTGTELDFALEICNAVLDVWKPtpdrkvIINLPATVELSMPHVYASQIEYMGKRLARRDAIVLSVHPHNDRGTGVAAAELAMLAGAERLEGTLFGNGERTGNVDIVTLALNLYSH----GIDPGLDFSNLPAIQARVEALTKMQVSRRHPYAGELVFTAFSGSHQDAIAKGMKWreekspehwtvpYLPIDPKDIGREYEgdIIRINSQSGKGGIGYVLEQsHGFDLPPKMREQLGYAVKRVSDREQKELSADEIAEIFMREFVNLGQPLDLVELTGTDARGSHRVRATVVWQGETVEIEGA-GNGRLDALCHALEEGLGIRVANLTYKEHALEVGSGSRAVAYISVDDeEGNTHFGCGVDTDIMEASAKALVSAVNRMLA----------------------
>UniRef50_A1KBD3(35-559:572) 2-isopropylmalate synthase n=14 Tax=Bacteria RepID=LEU1_AZOSB   E=1e-112 s/c=0.78 id=26% cov=94%
ITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRELIEgghIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFRRIVFDTDRAGVKQIAVDSARYfvemaARQPGtdFTFQYSPEVFSGTELDFAVEVANAVIEVWQPtpqqkcIINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQ----GVHPGLDFSRINEVARTVEHCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAvqqpdavwevPYLPVDPADLGRSyESIIRVNSQSGKGGIAYLLEaEYGLVMPRRLQVEFSAAIQRITDERGTELSAGDIWRAFEEEYlaVAAPYAYVEHHLAEHGGQQGIS---LTVEEAGVRRVLRGVGNGPIDAALHAL----DAGAVLLGYEERAIGQGGDARAVAYIELADgeGGGSTFGVGIHANIVTASVLAIVSALDRLAQRRE-------------------
>UniRef50_B8FYI5(32-552:557) Pyruvate carboxyltransferase n=5 Tax=Bacteria RepID=B8FYI5_DESHD   E=1e-107 s/c=0.75 id=22% cov=93%
--------SVDLRDGNQALVVPMSLEEKLEYYHMLLKIGFKEIEVGFPAASETEYAFLRTLIEQnliPEDVTIQVLTQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSREEIVEIAVSGARLLKKYAAETegnfqfEYSPESFTGTEMEFALEICNQVLDVFEPtpenkvIINLPATVSLSMPHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQRIEGTLFGNGERTGNVDIVTLALNLFSH----GVDPGLNFASMLEITAKYEALTRMKVHDRQPYGGKLVFAAFSGSHQDAITKGIKWreehechywnvpYLLIDPQDIGREYEgdVIRINSQSGKGGIAYMLEQHyALDLPAKMREAFGYKVKNVSDNLHKELMPEEIKDIFFKEYVNIENPIKFLNFHFL--NHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQARLGLSYSNLIYKEHALELGSKSQAVSYVGVTGpDGVIHWGCGIHTDIFTSSVKALISAINTMIK----------------------
>UniRef50_C0W2B6(3-538:551) Alpha-isopropylmalate/homocitrate synthase family transferase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W2B6_9ACTO  E=2e-96 s/c=0.66 id=27% cov=95%
LTPRVATYDTTLRDGAQQQSVSFTVEDKLAVARILDHLGVTYIEAGWPGAIPKDTEFFARAASELSlaTARLVAFGSTCHPGTaaekDPQLRGLLDSGAPVITIVAKSDPAHVERALRTSGEENLRMVADSVGLLVAAGREVMVDLEhyvDGVARDPRYGIELALTAARAGASAVIPCDTNGGSLPGTVAAEISRLRAALdaAGHEDCVVGIHTHDDSGLAVAAAMAAVEAGARQVQGCVNGFGERTGNANLLTLIANLELKTGYQALagdsqERARRLAELSAVSRTVGEIANRAPSGRLPYVGSKAFAHKAGLHASAIKVDPNLYQHVDPARVG-NTMTMLVSEMAGRASIELKARELGIETggDKELLARVTEVVKgREAAGYAYDAADGSFELLLRQALGQLPQYFRVESWRASvtarpaagqeilpedGATVTDSEATVRMWVGGRRLAVLGEGNGPVNALDHALCDALAtaypeiRAFELTDFKVRILDSerGTHAIVRVLIDITDGERSWSTVGVGTDIIEASWEALTDG----------------------------
>UniRef50_B3DXX9(1-373:380) Homocitrate/citramalate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DXX9_METI4  E=3e-93 s/c=0.92 id=32% cov=68%
MNGKILLADTTLRDGEQAPGVFFSPRQKVQIVKLLAQCGIKEIEAGTPSSCKTEMEAFHKILSLGLKVRIVAWGRMTNED----LQAVKSSRVSTVNLSIPLSDIQISTKLRTNRKQVLEKIKEYVGKAREMGLEVALGGEDSSRAEENFLVEAIEVAKQEGAFRFRYADTVGILDPLCTYQTLSRLKKW----TSFPLEFHGHDDFGMATANSIAAWRAGVASISATLCGLGERAGNGALEEIAFFLALR---ENVDVGIDLKGLFSLCLLTSRLSKRKIPPWKSIIGEEIFLHESGIHVDGILKNPRNYEPFNPSIIGR-KHRFTLGKHSGRKSVLWTYEKLGITLSEQKATEILHKIKNFTATKKR----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6TTX4(2-349:379) Pyruvate carboxyltransferase n=1 Tax=Alkaliphilus metalliredigens QYMF RepID=A6TTX4_ALKMQ  E=3e-93 s/c=0.99 id=33% cov=66%
-----YIVDTTLRDGEQTPGVVFLKKEKIKIARMLDELGVDYIEAGIPIMGEEEKDVIREIIAMNGKAKILTWNRMKKMDVDASL----ACGAKYIHIAVPASDIHIFQKLRKDRKWVIQQVQEVVSYGAEKGCIVSVGAEDASRAEEKFLIEIYQAAIKEGAVRLRYADTLGILTPITTYQAIKRICDYI----DADLEFHGHNDFGMATANSLSAFQAGAKYIDCSVNGLGERAGNTALEEIVMTLKY---LLKSNHPFEIKRILELSNIVQEASRKIVGESKPIVGKSVFSHESGIHVDGLLKNPTVYESFSPGEIGR-KRKIVLGKHSGRTTVIYRLQEMGIKVTPKEANEIIEMIHK-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7G5N8(8-561:581) 2-isopropylmalate synthase n=2 Tax=Bacillariophyta RepID=B7G5N8_PHATR  E=6e-92 s/c=0.61 id=27% cov=92%
------------RDGTQGESVSASVDDKLKITRRLVAFGVDFVEAGWPGSNPKDAAFFTRAKTDLTHAerdKLVAFGSTRRKRVraneDPQVQALLESQAPTVCIVAKAHAWQVTEILRATLDENLDMIRDTVACLVAHGRVVMVDLEhalDGYATDPDYVHACCRAAVDGGASVLVACDTNGGTMPWRVGTVVRELVDTY-GPQGVTIGMHAHNDCGMAVANSLTAAQYGAGLIQGTVNGIGERTGNADLCAIVPSLALHVQA-QLHCRASLATLTSLSRFVDEVLNQTPNHAAPFVGSSAFAHKGGLHVAAMERSPLSYQHIEPELVG-NEQRILISELSGRQNILGKMQQAGVDLgtsGSDRAVAILNRVKtleaqgytfegaeasvhlmilhatkgycppfQVLDYSAQVYDANIDSATRVLRHTESPDTDPTDSKKPRKapGFGPTARATVNVRTMRPIedglesylanlspyqdRLEVSDGNGPVDALANALMRALQpvhpilQHVELVDYKVRILDAenATGATTRVMIEFRNNSdgdqETWTTVSVDTNVISASLNALVDG----------------------------
>UniRef50_Q8KTR5(9-382:390) Alpha-isopropylmalate synthase n=14 Tax=Candidatus Tremblaya princeps RepID=Q8KTR5_TREPR  E=1e-88 s/c=0.88 id=43% cov=65%
----IAILDTTLRDGEQAPCIVMGPDAKAEMARRLEIAGVDVVEAGFAASSSSDFEAIRRISCCVRGCVVCSLARAVGHDVRKAAKALEFARHPRIHVFIGSSSLHIEEKLRMHPLDVVDRAAAMVRLARAYCDDVEFSPEDSSRADPSFLCSLAKAAVEAGATIVNVTDTVGHGIPEQLSDVAGMLCRSVPISDRVTLSVHCHNDVGLALANTMAAIACCAGQAECTVTGIGERAGNAALEEVVVAAGLEYSGAGMDVRVDARHMRSIAQLASAIARRRLPATKPVVGCHAFAHASGIHQDGVIKNRRTYEALRAEDVGGRGGSIVLGKLSGTHALRNRLE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8FAB3(7-363:374) Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAB3_DESAA  E=2e-85 s/c=0.89 id=32% cov=68%
----VHIIDTTLRDGEQAPGVAFDKREKIALAMMLDQAHVDELEVGIPAMGPAAQDEIKAIAGLNPDCLLTAWCRALKDDIDQSL----LCNVTGVHISFPVSDIHLEA-MGKTRSWVLNQLSVLIPYALQRFSRVSVGAQDAFRADMAFLEQFVHSANLRGAHRVRIADTVGLARPSQVENMVHVLSKA---AGKMALEFHGHNDLGMATANTIAAIEAGAQAVSVTVNGLGERAGNAPLEQVVVAAGTLDSR---STCVDARRLSEICRYVAEAVNRPIPADQPITGQAVFTHESGIHCAGILKNPDTYQPFNPETVGRERAQLVIGRHSGSGMIRHVLAKAGVRLEEGKTESLMAAVRMEALKKRSVL--------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B5HTY3(73-571:593) 2-isopropylmalate synthase n=1 Tax=Streptomyces sviceus ATCC 29083 RepID=B5HTY3_9ACTO  E=9e-84 s/c=0.63 id=25% cov=89%
-----LWSSVDLRDGNQALANPMDLRRKRKMFDLLVRLGFKDIEIGYPSASETEFEFVRHLItggHIPDDVTVTVFTPAIPELIDRTFEAVRGTDRAVVHLCHATACLWREVVFRKTPSEVMALAQESAQRLVRLadradgAIRFEYSPETFNVTEPQFALEIANTVAEIveatpeRPLTLNLPSTVEMHAPTVFADQIEWMSRNLDRRDGIILSVHPHNDRGTAVAAAEFALAAGADRVEGTLFGNGERTGNVCLITLALNLFSR----GVDPQLDLSDIPSVRRAAEECNRMPVPDRHPYAGDLVFTAFSGTHQDAIAKGLLHledqaaaagvpaaelpwdvpYLPVDPQDLGRSyEAVIRVNSQSGKGGIAHVLRtRWGIELPVALRAEFARVVQRVTDLSGTEVDPGRIWDV-----------FRAEYCDAGDWAGFTAPASGDDPAEALLAAARAYG---VDAHVEQLVRDEG-------------GPGSGARHVCYAQLFVAHEPVWGAGLGATAGEATVRAVLSALHR-------------------------
>UniRef50_A6FCI3(2-355:387) 2-isopropylmalate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FCI3_9GAMM  E=8e-83 s/c=0.88 id=33% cov=68%
--KKISILDTTLRDGEQAPENAMDPEKKLKMALMLEECGVDHIETGFPASSKFDYEATKLISKEVTQSGIATFSRTLTSDVQLSLESGGREKNHTIQMVATGSDLHLKNKRNISRSQAIEEVINTVKFAKQNSDcRIAVGIEDASRADFDFMGEITEAAVFAGAHQIILADTTGYATPSEFKKLIQFIRSKT--GDGISISTHCHNDLGLAHANTLAGIEGGADEVQVTLGGIGERAGNASLEMIASTLFFKPECYSSFTDIKLDKLYKVYQELCSEIGLDIPRNQPVFGTYAFSTAAGIHQQGVLANPDTYEFVKPDVFNR-EREFFVSRHSGKSIIKYILSNKAMDQDPKLLETLYA---------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7N750(2-470:471) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N750_SLAHD  E=1e-82 s/c=0.66 id=30% cov=90%
--RDVRVSDVTMRQAEVSGSLALTFKEKLETAKLLDSLGVSSIEIEGVERSKADALRIKSIASIVKNSVLAVPVKMDDENIQVVWGALKNAAFPRLQVVAAVSPARMEYVYHKKADGMMKDVAATIAKCAALTDDVEFVADDATRADSVYLRSVIKEAIQAGAKTITVCDDAGTMLPEEFAQFIDDLRKDLPELADVALGISCSNDLFMADACAIAGIMSGVDEIKATTYPM----NVISLEKVCKVLAAKPEICQAQTTVRVTELKRTAAQVARICEQ---------------------------GRSKYSAFNPNVTGSDES-FVLTVNDDIDAVMECVAKLGYELSEEDATNVYEAFLRIASKKDSVSNLELDAIVASAALQ-VPATYVLENYVINSGNAIKATANVRMRKGDEVLEAVCIGDGPIDASFLAIEKISGKRYELDDWQMQSVTEGQEAMGQAIVKLVADGKIYSGRGISTDIVGSSIRAYVNALNKIVYEEE-------------------
>UniRef50_A7IBL6(35-403:415) Homocitrate synthase n=19 Tax=Proteobacteria RepID=A7IBL6_XANP2   E=6e-82 s/c=0.83 id=35% cov=66%
--------DTTLRDGEQAPGVAFTRREKIEIAEALAAAGVPEIEAGTPAMGDEEIETLRSIVSLKLPLRVAAWCRMSEED----LFAAVSAGVTYVNLSIPTSDRQLKGKLNRDRDWALGALRHVVTLATKLGFTAAVGCEDASRADPDFLCKVAEVAKEAGAFRLRLADTLGVLDPFSAYALVR----RVANATDLEIEFHAHDDLGLATANTLAAVTGGARHASVTVAGLGERAGNAALEEVAIALR---QTARSETGIDPHALRPLAQKVMEAAGRPMPRTKAIVGEDIFTHESGIHVSGLLKDRGTYEALSPEMLGRS-HRVVLGKHSGLAAILKALSDQGLAVDEARGRAILARVRDFA---------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8TLL5(1-385:385) Homocitrate synthase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TLL5_9PROT  E=9e-65 s/c=0.65 id=30% cov=68%
----VVIVDSTLREGEQFVHADFSRDAKLEIARALTSFGVNYLEVTSPAASRRSRTDAATIANAGLPAMVAAHIRCHKDDAAIAID----TGVGALHMVMATSPILRAASHGKAIAEVVRIAAEVGEFVRNRapNIELRFSSEDAFRCPLNDLMNVYLPLSELRlFDRFGLADTTGAATPDRVAEVVNLLRR----LTTTPIEFHGHNDIGCAIANAHAAAMNGATHINTTVLGLGERNGITPLEGLIAVMYA-ADRGRTMAQFQLSELPALCRRVAELAGVAVPFNQVLVGESAFSHKAGMHTKAVHNDPRSYEAMDPSDFGLTREIAISHRLTGWNAVRVRADALGLRLALADLKEATSRVKSAADE-------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8W3E1(3-270:287) Pyruvate carboxyltransferase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8W3E1_DESAS  E=7e-64 s/c=0.92 id=33% cov=46%
---KVCIVDTTLRDGEQSPGVAFSAKEKIKIAQYLDLLGVEQIELGIPAMGGIEVDAISSIASLDLKARLTTWNRLHLSDIRASL----SCRVKNLHICAPVSDIQIEYKLNKSRLWVLDCLKRAIRYAKDYGCWISVGAEDASRADPEFLLEYALLAQEMGAERLRYADTVGVLEPFSTYRELSWLKDKL----KIELEFHGHNDFGLATANTVAAVNAGVRFIDVTVNGLGERAGNANMEEVVAAIRM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2KBD6(1-379:416) Pyruvate carboxyltransferase n=7 Tax=Bacteria RepID=B2KBD6_ELUMP   E=2e-60 s/c=0.62 id=30% cov=67%
MSDKlIYIVDVTNRDGVQTSRLGLAKLQKTLVNIYLDEMGITQSEFGFP-TTQHEINYLNAnldLAERggIKKTVLSGWMRALESDVVLAFKNVP--KLKTVNLSISTSDQMIQGKFggRKTRKDIINQMTAAVKKAYECGAElVGVNSEDASRTDQEYLVEFALAAKAAGAKRLRYCDTLGYDSPDVAYSRLNDLAKR----TCLDLEMHFHNDLGMAVANSVRgaqgAIDGGVNaYINTAVNGMGERSGNADLACCVLAVlksSGFSGKYKIDPDIDMSKIWPLAKYTSYSFGVPIPINYPAVGGNAFAHESGIHADGALKDRRNYELYDYEELGRGEpevietgRMITTGEYGGIKGFRDVYEKLSIEfKDEKEARNILE---------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8MBK1(17-402:419) Pyruvate carboxyltransferase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MBK1_CALMQ  E=2e-59 s/c=0.60 id=26% cov=67%
-PSELYITDTTFRDGQQA-FYAYSPSDVKGLFKLLSEL-----DNGSGRLSRSEFflytERDRRIVNAVKGlglkyPKVIGWGRARVEDVRL----VKESGLDEMVMLMSISDIHIKAKFNTTRARVVEKYLEAAEEAMRSGIALRCSLEDVTRADvlgfvVPFVNKLLRLRDKYGASlVIKLPDTTGVGVPYPTASLpysipkLIWVMRSLLKIPSNALEFHGHGDYHMAVANAVAAWVYGAGINNGTLLGIGERAGNVPIEALVVWYsRLKGSFDGMEPRV-------ISRIVEYFkgMGYSVPRHQPIVGSNAYATAAGIHIDAQSKDPETYLSMDPSLVGM-RETILIGPYTGRSGIAHVLKGIGVNagKNDETVERVYRAVVRLYDEGR-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2J8P8(6-382:392) Pyruvate carboxyltransferase n=2 Tax=Nostocaceae RepID=B2J8P8_NOSP7   E=3e-54 s/c=0.57 id=28% cov=61%
----IIISDETLRDGEQQAGIFFSYPTKQKLAHLIAQTGVDRLSM-MPRVHEQEEELVKSLVSEGLDSLIAAATMTGKQYIDQA----KMYGVKRIILFYGLSDRLLflrdpqirllnefkgktidddipKKVIERIRQNAIDLIVENLHYATTvAGLTVDFAAEDASRADFDFLVQCIRSFSPY-LDHFMLCDTVGVLTPEKSYIWINDLLQR---TTGVAFGVHYHNDMGLALENTLQSVIAGATLVSGTFCGIGERAGNVAIEQVLNGLRVRFGIE--VKGINYDAIAAVTDYIEQL-GIRPAP--PYS-QTAQRHESGIHVNSLFSDPQSY-----AALPYNTIEVLFGKWSGISNFQYLFE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8TB92(74-364:370) Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 n=26 Tax=cellular organisms RepID=HMGC2_HUMAN  E=2e-53 s/c=0.73 id=24% cov=51%
LPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSrwvPQMADhtEVMKGIHQYPGVRYPVLTPNL-----QGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEgsitpqKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPG---ALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGgcpyakGASGNVATEDLIYMLN----GLGLNTGVNLYKVMEagdfICKAVNKTTN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9F2G5(25-310:328) Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=A9F2G5_SORC5   E=6e-52 s/c=0.72 id=23% cov=52%
-ADEVSIYEVSPRDGLQNESAMIPIEGKRRLIAALVGAGLRRIEITsfvSPKWVPQlaDAEELARTLPAERGVTFSALCPNARG-----LERALAVGLREIAVFLSASEAHNRANINKSIDDTLSVFSEIVPPAREAGLAVRayvstvWGCPYEGDVDPARVVRIAERLIDLGCYQVSLGDTIGVGTPRQTHDIVRRFLDAMPPER---FALHLHDTRGTALANILVGLELGVRDFDASVAGVGgcpyapGAAGNMATEDLVFML----HGMGVRTGVDLDKVIEAGNVAEQVIGRPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4VK95(31-317:338) Hydroxymethylglutaryl-CoA lyase n=63 Tax=cellular organisms RepID=A4VK95_PSEU5  E=5e-51 s/c=0.71 id=24% cov=43%
MSKRLHIQEVATRDGFQIEANFVPTEAKIALIDRLSQTGLAKIEVtsfTSPKAIPnlRDAEDVMRGIRRAEGVEYTVLVPNARG-----CERALACEVDEINLVMSASDTHGLANLRMTPEQSLVQFREIIEVTRGSGvfinasLSTTFGCPFEGDVPERRIYELVQRLLEIGVQGITLCDTTGMADPAQVERICREVLSRWP---DAVFTAHFHNTRGMGLANALAALNAGIDRFDASLGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6QTB6(1-296:564) 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase n=2 Tax=Trichocomaceae RepID=B6QTB6_PENMQ  E=7e-51 s/c=0.69 id=22% cov=50%
MTRpkvpEVRIVEVGPRDGLQSIKDAVPTETKTELIQRLWRAGLRSIELTSIVStrkVPQLADcqeilnnpAIRSLTEdsEASGLRLPVLTPNLKG-----LDIALSRGVKEVAVFISATEGFSQANINCSVEQGVEKARAVAQKAIEAGIAVRGYVSCIFVDPYDGptnpssVLRCVQELLQMGCYEVSLGDTTGAGTPAKVATLIRYLEKNGVSLRN--LAGHFHDTYGQAVANVLQAYICGIRVFDASVGGLGGCPfapgakGNVSTEEVVFM----FQNAGIQTGVNLEELVAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0Z8X0(11-293:312) Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Edwardsiella tarda EIB202 RepID=D0Z8X0_EDWTE  E=9e-51 s/c=0.72 id=22% cov=48%
------------RDGFQNIEQWIPTETKINIVEGIFRSGVKNIEVTsfvSPKAIPQMKDAAivaeyAVAMAKNTDVNIMALIPNVKG-----AERALSCGIRKVNYIISASPLHNKKNMNRTPQESFEALCELKKNFPEadvtLGVATAFGCPFQGKVPVDDVITLMRAARDIGINSFTLCDTIGVANPRQVETLLHEVKKNF---SDIQLALHLHNTHGMALANIYAAMLQGVDRFESAIGGLGgcpfapGAAGNAATEDLVNMLN----RMEINSNIDLAKLLDVANQIREL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4RE97(1-299:309) 3-hydroxy-3-methylglutarate-CoA lyase n=4 Tax=Bacteria RepID=B4RE97_PHEZH  E=4e-50 s/c=0.68 id=21% cov=53%
MSRRIEIVEVGPRDGLQNEKTLLEVDQKLEMIRRLEDAGARRMEVVSfvnPRRVPQMAGAEEIMAALNtPGAKPAGRSRIGLVLNQKGWERCVAAACDEANVVVCASDGFGIRNQGASVAEQIDALGAIMQARRledppvTVTVSVAFGCPFDGEVPEERVVDIVRTAADMRVAEIALADTIGVADPWTVRRRVEAARKA---AGRIPLRLHFHDTRNTGLANAYAGVEAGVDILDASVGGLGGcpfapnATGNIGTEDLVYML----ERGGFETGYDLDKLIEIGRWVSGLLGKPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6MHG9(1-294:311) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MHG9_BDEBA  E=1e-49 s/c=0.68 id=22% cov=49%
MKKSVVIVEMGLRDGLQNEKTVLDADTRVEFARRLILAGTKRVEIGafvSPTWVPQMAGTAEVVQKTfalvksgsiPKKTEFSVLVPNERGMMD-----AIASGVKEVAIFAACSESFSLKNINCSIDESFKRFEPVMALAKKHKIKVrgylstCFGCPFEGRVSEAKVVKLAQRMHKLGVYELSIGDTIGVADVGQVESLFRK---LKKVVPVKKLAGHFHDTRGQALANILAAYKLGINVFDTSLGGLGgcpyapGATGNVATEDVVYM----FHGMGVKTGLNLDKLIEI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5V0V3(23-308:328) Pyruvate carboxyltransferase n=6 Tax=Chloroflexi (class) RepID=A5V0V3_ROSS1  E=7e-49 s/c=0.69 id=21% cov=50%
------------RDGLQNEDVILTTTQKVQLIDRLADTGLTLIEVGAfvrPANVPQMADtaDVFAAISRRPGVVYSAIVPNAIG-----ARRAVAAQADALQVFLSASESHNRSNVNMSIEQSLAQAADIAAIareagvCFEAVVSVAFGCPFEGDVPLDRVMDLTARLFDLGAEQVTFGDTTGMGHPALVRDLVLAFYERFPQAHP---RLHLHSARGAGLANVLMALSLGVDRFDASVGGIGgcpfapGAPGNICTEDLVHML----HEMGISTGIRLPALLDVARMLEGMLGRTVP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5WKL8(13-294:309) Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacillaceae RepID=Q5WKL8_BACSK  E=8e-49 s/c=0.70 id=23% cov=49%
------------RDGLQNEQVRLSVEQKIEMMEHAARSGISKIEAVS-FVNKKlvpamaDAEEVMAAWHRREGVRIAGLALSRSG-----ITRALQTPIDVLHITISASDAFNKRNANKTVAEGLSDLLPVVGEASTHlpvvtVISTSFGCPFSGDVQMETVFSVCESFLKAGATEMVLADTTGMANPRQVAETVRGFYRTFGE--DIPLGLHFHNTRGLGLANAVAGYDAGVRRFDSAVGGLGGcpfapkATGNICTEDLVHM----FHEMGIDTGTDLDGLITLAQQVEKWMG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1ZLV9(65-376:407) Whole genome shotgun sequence assembly, scaffold_57 n=1 Tax=Sordaria macrospora RepID=D1ZLV9_SORMA  E=5e-46 s/c=0.60 id=22% cov=50%
---RVKIVEVGPRDGLQNEKKSIPLATKIELIERLAKTGLQTIEAGafvSPKWVPQMAnssEILEHLLKTPPPSPVPltySFLAPNTKGLDSAFSLLSQYpkafetetagrsskvaqeggkPALEIAVFAAATESFSQKNLNCSIDTSLTRFKDVIQQAKAANLRVRAYISVvlgcpfeGYDVDPHRVASIATTLLEMGADEISLGDTTGMGTAPRTKELLSCLSSA--GIRNEDLAMHFHDTYGQALVNTAVALEHGIRTFDSSVGGLGgcpyspGATGNVATENVVYFM----ESLGMDTGVDLDRVADI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q28T96(1-270:284) Hydroxymethylglutaryl-CoA lyase n=8 Tax=Proteobacteria RepID=Q28T96_JANSC  E=9e-46 s/c=0.69 id=27% cov=43%
MTEWVDIFEVGPRDGLQNEARLIPTDDKIALINLLSRAGFRRIEVAsfvSPKWVPQMADgaDVLAGITRAPGVSYAALTPNMRG-----YDGALGAKADEIAIFASASEGFSKANLNATIAESLVRFADVAQAARAAGVPMRGYvscvtqCPFDGETPPENVARVAAALRDMGAYEISLGDTLGRAYPAQVDAMLAAV---LPEVPAGRLAGHFHDTSGRALDNVDAALARGLRVFDGAVGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9IR28(6-259:306) Hydroxymethylglutaryl-CoA lyase n=5 Tax=Bacteria RepID=A9IR28_BORPD   E=3e-45 s/c=0.73 id=22% cov=41%
------------RDGLQNEPEILSTGQKVELIERALAAGLRRIEAVSfvnPRRVPQmaDAEAVMKAVPRRPGVTYSGLALNVRG-----AQRAVDAGVDEINYVVVSTDSYNQANQGCPSDETLRGWGQVATLARDAGLRatltvaASFGCPFEGEVDVDRVVHIARQAAAEGADEIILADSIGVASPADVLQRVDAVQQALP---DAALRCHFHNTRNTGIANVLAAMQAGVRVFDASIGGIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0VL35(44-329:350) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Alcanivorax RepID=Q0VL35_ALCBS  E=2e-44 s/c=0.64 id=22% cov=51%
MTDQAIINEVGLRDGLQNQPVTVDTATKAKLAQLLVDAGMRYLEpvsFVSPKAIPQMADAAALtpLLPQGNDLHYTALIPNLKG-----YQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQAAQSCEAIIAAAKADGIATRTYISGAFACPYDGPVpvtlpqKLSERMFAAGSDEVAIADTIGAGNPQQMKDIMAPLIQEF---GAEKFYVHLHDTRGLAAAMAWAAADLGVRRFDASIGGLGgcpfapGATGNMATEDLVYLL----ESAGLKTGIDVQGLREAVALAAEATQRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O27179(4-273:568) Pyruvate carboxylase subunit B n=36 Tax=cellular organisms RepID=PYCB_METTH  E=1e-41 s/c=0.64 id=17% cov=48%
----IKVVETAFRDAHQSlLATRLRTRDMTPIAEEMDRVGFFSLEAWGGAtfdtciryLNEDPWERLRELKEHVKRTPIQMLLRGQnlvgykhypDDIVRKFIEKSYENGVDVFRIFDALNDIRNmEYAIKVAREQ-----EAHVQGVICYTISPYHTLES--------YVDFARELEALECDSVAIKDMAGLISPHDAYELVRALKEE----TDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQPPTESIVAALR----DTPYDTGLDLEILKNIKKYFEEI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4IT42(5-271:342) 4-hydroxy-2-oxovalerate aldolase n=4 Tax=Bacteria RepID=HOA_GEOTN   E=2e-40 s/c=0.63 id=20% cov=49%
--RDIWITEVALRDGSHAINHQYTVEQVVSVAQALDEANVPYIEVShgdglagsslqYGLSRTDEMELIEAAVSVCKKAKIAVLLLPGIGTI-RELDAAAKRGVKMVRIATHVTEA--------------DISAQHITRAKELGLEAVGFLMMSHMASTEKLVEQAKLMESYGADVVYVVDSAGALLPHEVTERIRALKQSL----GIEIGFHGHNNLSLAMANTLAAIQEGATRIDGSVRCLGAGAGNTQTEVLVAVL----DRIGLKTGVDLYKMMDLAeEIVAPILQVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8H935(8-268:326) Pyruvate carboxyltransferase n=7 Tax=Actinomycetales RepID=B8H935_ARTCA  E=9e-40 s/c=0.64 id=26% cov=44%
MLAKTILRDVTLRDGLQLTGKVLSTERKVETVRELIRLGVPAIELGSMARadlVPTMANTLEVVQALTPEELEKCWIWVATPG---HVAKASAAGARNFQYCLSASDSHNKANIGRTTEESLAALPEAVTYTqsvngqIQLCIATSFTCPFEGYVPEERILSIANDPRAEGTTDIVLCDTLGQAIPTQVAGLINRVREESPARRIV---YHGHDTWGLGVANTLAAIQAGAAMVDGALGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6BTH8(3-328:337) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=beta proteobacterium KB13 RepID=B6BTH8_9PROT  E=2e-39 s/c=0.51 id=23% cov=48%
-SKKILISDPTLRDGSHAIKHKFSKDDISNYCKLADKARIPIVEVGHGngiGASSlqlgesllSDFDMLSTARKNLKKSKLGVHVIPGFATIDKDILPAVDVGVDVFRIATHCTES--------------DLSERHISFLRKKNLEVWGCLMMAHMVDTETLIDQAKKIENYGADGVIFMDSAGSFIPNQIKERVEGLVSEL----NIMVGFHGHNNLNLAVANSLEAIQSGATLVDACSAGFGAGAGNTQLEVLIPVLLKQ----NFDTNIDFNGLLDLAEFV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0TK18(1-271:603) Oxaloacetate decarboxylase alpha subunit n=37 Tax=Bacteria RepID=B0TK18_SHEHH  E=7e-39 s/c=0.61 id=21% cov=39%
MSKPLALTDVALRDAHQSiLATRLRTEDMLPIAPLLDKVGFWSLE-SWGGAtfdscirylGEDPWERIRELKKVMPNTPQQMLLRGQnllgyrhyaDDLVHRFVERAHTNGVDVFRVFDAMNDVRN--------------LETAVKAVVEVGGHAQGTIS-YTTSPVHNLntwIDMAKRIEDMGCHSLCIKDMAGLLKPFEAFELISQIKS----QTDLVLSLHCHATTGLSTATYQKAIEAGID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q07TZ1(532-809:1149) Pyruvate carboxylase n=41 Tax=Bacteria RepID=Q07TZ1_RHOP5   E=9e-39 s/c=0.59 id=23% cov=46%
--KRVLVTDTTMRDGHQSlLATRMRSHDLVEVAEsyatglpqlfSLECWGGATFDVAMRFLTEDPWERLSQIRERVPNILLQMLLRGAngvgytnypDNVVRFFVREAAKGGVDVFRIFDALNW---MENIHPAID-AVASENKIAEAAVCYTGDIL--DPDRAKYSLKYYVDLAKEMERAGAHILGVKDMAGLLKPQAAKVLFKALREEI----QIPIHFHTHDTSGIAAASVLAAVEAGVDAVDAAMDALSGLTSQPCLGSIVAALK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9P0G7(5-251:354) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Vibrio coralliilyticus ATCC BAA-450 RepID=C9P0G7_9VIBR  E=9e-37 s/c=0.64 id=27% cov=41%
------ILECTLRDGSYEIDFQFSKKNADDIALALDEAGFELIEVGHgvglgatekkiGVALESDEVYMKSAAESVTNGKWGMFAIPGIATLEH-LEMAKNYDMDFIRI-------------GSTIED-FPKSEAFVSSAKSQGMMTCANFMKSYAAKPEDLAQASKLAFEMGVDAVYVVDSAGGMLPNEVKLYVEAI---LAEKSDAVIGFHGHNNLGLGIGNALAAIEAGASIIDTSLQGFGRSAGNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P11498(563-844:1178) Pyruvate carboxylase, mitochondrial n=54 Tax=root RepID=PYC_HUMAN   E=1e-36 s/c=0.56 id=24% cov=41%
----LLLMDTTFRDAHQSlLATRVRTHDLKKIAPYvahnfsklfsMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGAnavgytnypDNVVFKFCEVAKENGMDVFRVFDSLNYLPNML-LGM---EAAGSAGGVVEAAISYTGDVA--DPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDL---PLHIHTHDTSGAGVAAMLACAQAGADVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q88LY5(4-246:534) Aldolase/synthase, putative n=6 Tax=Proteobacteria RepID=Q88LY5_PSEPK  E=1e-36 s/c=0.64 id=21% cov=45%
-------LDCTLRDGGYYNNWNFSEALIAQYITAMQAAGIQTIELGlrslknssFSGACAYTTDAFLSTLDLPPSMTIGVMVNGSELVGKNAGQQALQ-----LLFPSPASESPVDLVRIACHVHEFAEALPAASWLKERGYDVGFNLMQIANCSESEIKALAKLANNYPLDVLYFADSMGSMSPDDAAQIIQWLRSEWQG----ALGIHTHDNLGLALSNTLRAMDEGVTWVDSTVTGMGRGPGNARTEELAIEIAAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2R6U4(532-807:1146) Pyruvate carboxylase n=6 Tax=cellular organisms RepID=D2R6U4_9PLAN   E=4e-36 s/c=0.56 id=21% cov=37%
--------DTTFRDAHQSlLATRFRTKDLLNVAEAyahlasdlfsLEMWGGATFDTSMRFLKECPWQRLADMREKVPNICFQMLFRASnavgyssypDNIVREFCSEATAAGMDIFRIFDALNFLPNMRVA----MEAVQKAGGVCEPAICYTGDILN--PARSKYDLKYYVELAKELEKSGAHILAIKDMAGLCKPYAAELLVKTLKQEI----GIPIHFHTHDTAGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8M6W8(1-309:348) 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Salinispora arenicola CNS-205 RepID=HOA2_SALAI  E=2e-35 s/c=0.50 id=26% cov=45%
MSVKLQICDSTLRDGNHAVAHQLGRADISAYARAAEEAGVDVLEVGHgnglgassiqvGIAAVSDAEMLRAAKAELRNSRLGVLSIPGFASVERDLKPALDCGVDEVRVGAHCTEA--------------DVTRQQITMLRSMGVRVKGLLLMSHMASAGKLVEQAGLMQEYGAEAVVLMDSAGAYTPEMVREKVGELVEKL----DIAIGFHAHNNLGLSVINSITAVRAGASIVDVTARGFGAGAGNAPIELVAANLHV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4U857(2-287:619) Oxaloacetate decarboxylase alpha subunit n=10 Tax=cellular organisms RepID=B4U857_HYDS0  E=2e-35 s/c=0.53 id=20% cov=39%
--EKLYFTDVSLRDGIQSlLATRVRTEDMLPALEILDKCGFWSLEV-WGGATfdvclrylkEDPWERLKQFKNITKNTKLEMLLRGQnivgyrnypDDVVEAFVKKSYDNGVEVFRIFDALNDVRNMRKAIETGKSLNAIVKGVLSYTTSPVHTV------------EYYVKIAKDLVNMGIDIISIKDQSGILTPKMAFDLVKALKQEF----KLPIHIHTQTTAELANMSQLKALEAGATM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5EHC6(25-287:465) Pyruvate carboxylase subunit B n=2 Tax=Clostridiales RepID=C5EHC6_9FIRM  E=4e-35 s/c=0.57 id=19% cov=38%
------------RDGQQSLfATRMTTADMVPLLSAMDQVGYDSMEmwggatfdVAVRFLKEDPWDRIREFKKYVKRTPLKMVLRGQnlvgykaypDDVVEKFVEKAAAAGIDVFLIFDALQDLRN-----------CESAFRAVKKAgKKIEGSIQYNISPFH--TIEKFVENGKEQEKMGVSLLHVEDMAGLMTPAAAYDLIKALKAEL----KVPIHLHCHCTGGMAEMAYWEAIRAGVDGLDVCV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q039M6(527-790:1145) Pyruvate carboxylase n=9 Tax=Lactobacillaceae RepID=Q039M6_LACC3   E=2e-34 s/c=0.57 id=21% cov=41%
---QLLLTDTTFRDAHQSLfATRMRTRDMLTVAQdmgnglpnlfSMEVWGGATFDVAYRFLNEDPWTRLKKLRAALPHTLLQMLFRGSnavgyqnypDNVIKAFIQKAADDGVDVFRIFDSLNWLPQMT---LSID-TVKQTGKLAEATMCYTGDI---LSHAHpKYQLAYYVDLAKQLVAAGADMLAIKDMAGLLKPQAATELVTALKDAV----SVPIHLHTHDTTGNGIATYVAAANAGVDIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1YV80(10-281:328) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 RepID=C1YV80_NOCDA  E=2e-34 s/c=0.55 id=24% cov=43%
-PRRPRILDVTLRDGGYLNDWRFTDATVREHTKVLGEVGVPYVEVGYisddPGREPTLRcapDLLRQVGEDAGPARVVAMlaVNGRSPDEVAALLRPRAEVLDVVRL--------------TCLLERLDHVLAAAEAVRASGVTCSLNLISVTAYEPGELAGAAERVARAGvADWLYLADSRGALLPEHAAELFAGVRAAWPGLA----GFHGHDNLGHAVANSRIALEAGFDLVDGSLHGYGLGGGNTDLAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3P825(2-271:347) 4-hydroxy-2-oxovalerate aldolase n=20 Tax=Burkholderia RepID=HOA_BURP0  E=3e-34 s/c=0.55 id=28% cov=43%
----ILISDATLRDGNHAIRHQLSAAQIHAYARAADEAGIDVVEVGHGnglggsscllGQTPiGDRLMLETARAALRTSRLGVHfipGLGKAADISLALE----IGVDVVRVATHCTEANVSARF--------------IEQTRTAGRTAFGVLMMSHMAPPDTLLAQAKLMERYGAQAVVLMDSAGYSTPSLVRAKVERLVDGL----DIDVGFHAHNNLGLAVANSLVALEAGARIVDACVKGFGAGAGNTQLETLVAAM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3VWM4(1-283:490) Probable carboxylase n=2 Tax=Rhodobacteraceae RepID=A3VWM4_9RHOB   E=9e-34 s/c=0.52 id=21% cov=40%
MSRTIRLVDVTLRDAHQCLwATRMTTAMMQDIAPRLNRAGFEAIDLVGGAVfdvcvrylREDPWERMRILNQWITETPLIIHTRGQslftfeffpDDIVELAAERFAANGMRYHTPYDALNDMRNLEI--------------PVRAAKQHGLHVVGGLVYTFSpvHTDAYYQKKAKELMALGVDGIFLKDASGLLRPERIATLVPALKTVMGNM---PLQIHTHCNSGLAPYVVLQAVEHGVDVVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6CWI0(9-247:320) Pyruvate carboxyltransferase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CWI0_PAESJ  E=1e-33 s/c=0.62 id=26% cov=42%
------IVDCTIRDGGLVNNWDFSVEFVQHLYNTLNEAGVDYMEIGY-KNSPKllkgadtagpwrflDDNFLKQVIPNKGNTKLSALVdigRVDENDILPRSESLLD--LIRVACYI----------------QDVDKALQLVQLFHERGYETTLNIMALSNVMENQLIEAFELIKESVVDVVYIVDSYGSLKPNDYSYLIEKFQHHLPNKR---LGIHTHNNMQLAFANTLLAAEKGVELLDASVYGMGRAAGNCNTELLVANLQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1C8U1(1-282:522) Pyruvate carboxylase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C8U1_SPHTD  E=1e-33 s/c=0.52 id=20% cov=41%
MTSRIQLIDVTLRDGNQSLwsATGIDTETVLAVAPLLDQVGFKALDFttsTHMAISvryhqEDPFERIRLTSQLMPNTplifmttgmRFITWEPAPRAIIRLAMQLVIKHGIRRIQIVEPMN--------------NMPALLEAAKIAREEGAEQVVAGLVYSISPVhtdEFYVGCAAALAGAtdLIDTVYIKDPSGLLTPERVETIVPAMRKAL---GSMPLEIHSHCNAGMAPLCYLRAAELGVETVHTAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0MS84(2-267:528) Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MS84_9FIRM  E=4e-33 s/c=0.55 id=20% cov=38%
--KRIRILDCTLRDGGYINNWKFGYENIKDTVRRLIQAGIDIIEAGY-LSSKGDFSA-----DESQYSSVDAIKRILPADRKNTLIAVMincgDYDAELLPQYDGTGPDCIRVCFHKSQAL---QAVELCRKIKEKGYKVYFQPMVALSYSDAEYLGLIGMANKFRPDGFYIVDSHGSMKQKDVARFFYLIENNLDK--EIAVGFHSHNNLQLSYSN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1VRH5(2-270:340) 4-hydroxy-2-oxovalerate aldolase n=14 Tax=cellular organisms RepID=HOA_STRGG  E=1e-32 s/c=0.53 id=25% cov=48%
--KQVVIHDPTLRDGQHAVHHRLGLTELRRYAEAADAARVPVVEVGHgnglgasslqvGLAAATDDAMLSTVREALRHSRLGTFMLPGWGTSDD-LRRAISHGVDVFRVGVHATEASL--------------AEHHLGFLRDAGAEAHCVLMMSHMASPGELAEQAARAVGYGAQAVGIMDSAGHFLPPDVTARIGAIVEAV---GTVPVIFHGHNNLGMAVANSVAAAEAGARIIDGCARGFGAGAGNTQLEVLVPVL----ERSGFATGIDLYALLDAADLAER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001788D72(4-263:321) pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001788D72  E=2e-32 s/c=0.55 id=26% cov=43%
-SSQTKIVDCTIRDGGLVNNWDFSVEFVQNLYAGLNEAGVDYMEIGY-KNSPKllkgadqagpwrflDDEFLREVIPHKGKTKLSALVdigRVDEDDILPREESLLD--LIRVACYIK----------------DVDKALALVQTFHDRGYETTLNIMALSNVMENELLEAFEMIRESVVDVVYIVDSYGSLDHKDMEYLVNKFKTHLPNKR---LGVHTHNNMQLAFSNTLVAADLGVELLDASVYGMGRAAGNCPTELLVTHLK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0WJX1(29-321:518) Possible pyruvate carboxylase n=1 Tax=Corynebacterium accolens ATCC 49725 RepID=C0WJX1_9CORY  E=2e-31 s/c=0.48 id=19% cov=40%
--RKINIIDTTLRDAHQSIwATRMTTSHILSLLDDITNAGFEHVDLVAPIqfdvsvryLKEDPWERVRLVHEnAAPGTKFRALIRSKnlasfdflpDDAILNWTERLYANGFRVIGSFDGLND--------------IDNIDQGLKLAKELGAETFGalsYCLSPVHTDDLYKRKATELLERTDVDRIMLKDAGGLLTPDRLKTLIPAIRSSI---GDVPLEVHTHSLTGLSPLTYLYAAELGVDSIHTSI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8HXT4(546-847:1165) Pyruvate carboxylase (Fragment) n=2 Tax=cellular organisms RepID=A8HXT4_CHLRE  E=5e-31 s/c=0.46 id=22% cov=42%
----VLITDTTMRDAHQSlLATRMRTHDMLKAAPAtaailsqagsLEMWGGATFDVSLRFLHECPWRRLERLRELIPNVPFQVRGVAGAPVCSHVGDGVGRAALVRVRQPhgLKVNPSIHEPVHQPLLPLPPPPRCQAWATLSSSLYCIGFG-EGAkthSQYQLDYYLDLAEKLVEHGCHALAIKDMAGLLKPRAATILVGALRQRFPNT---VIHVHTHDSAGTGVATQLAAAAAGADIVDCCV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI00019062DB(1-218:242) 2-isopropylmalate synthase n=1 Tax=Rhizobium etli IE4771 RepID=UPI00019062DB  E=5e-31 s/c=0.63 id=23% cov=32%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGADRVEGTLFGNGERTGNVDVVTMALNMFTQ----GIDPGIDCSNIERIKEVFEYSNQMAISERHPYVGELVYTAFSGSHQDAINKGMKaaqvanhpvwevPYLPIDPRDVGRSyEAIIRINSQSGKGGIAYILQQdYGLNLPRNLQVEFREDIQRITDVEGKELPSKRIYERFIERYVTQPE--------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2GNI7(339-569:595) Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GNI7_CHAGB  E=1e-30 s/c=0.59 id=22% cov=35%
------------RDGLQNEKRAIPLATKLELIERLAKTGLTTIEAGS-FVSPK-WD-------------------------KPALE---------IAVFASATESFSQRNLNCDIATSLARFRDVIQAAKDtHALRVRAYISVvlgcpfeGYDVDPHRVAHVATELLEMGADEIALRDTT-----------------------------RDGDCAEDALVNTAVALEHGIRTFDCSVGGLGgcpyspGATGNVATEDVVYFM----ETLGMDTGVDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5AMG4(11-249:305) MhpE-like protein n=1 Tax=Burkholderia glumae BGR1 RepID=C5AMG4_BURGB  E=6e-30 s/c=0.56 id=28% cov=43%
-ARAVTLLDCTLRDGGYLNGHDFSAPQIDAILTRLLASGVDVIEVGYFRRRNVERHPSTVIARCPP-AFLASLARTQavryavmvpPGDAEPAdLDELAELPVSVVRF--------------TCTDQNLPKVLALGERAARLGLVVCANITRVSERSHSQLAALTRALAEAGFDTVYAADSNGALYPDEVAAIVGEMRRHFTG----QIGFHAHDSLHLAFANALAAMRAGASWVDGTIGGVGKGGGNAAIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1B6B3(16-296:499) Putative carboxyltransferase n=1 Tax=Rhodococcus opacus B4 RepID=C1B6B3_RHOOB  E=8e-28 s/c=0.45 id=20% cov=40%
--RKIDIVDQTLRDGPQSwWGMRLRKDMGLPMAAELDRTGFHTIDLAGSSIFevlvrhckEDPWEQLISLSKSMPETTvragtrsngIVTFGLTADSVMDLWVQRLIAHGIGSFWIYDG---LFNIDKIGR--------LVKTVQAEGGQALPCILYADTPYHTDEYYAAR-TRELVATGADGIELEDAAGLLTPERTRSLVAAIK---GAAGNLPVEVHFHSNNALAPLNYLEAVLAGADRVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9L9W1(3-286:588) Biotin/lipoyl attachment n=3 Tax=Epsilonproteobacteria RepID=B9L9W1_NAUPA  E=1e-26 s/c=0.44 id=22% cov=40%
-TKYIDVMDTTFRDGFQSVfGGRVLMKDFLPAVDAAVEAGIKHFEFGGGARFqslffylqENAFDMMDEFAKRAKGANLQILARGIntvmldtgsREMIDLFAKLFAKHNTTTVRNFDALND--------------VNNLIYSGQAIKNAGMkhEVVVTIMDlppgcSGAHTVEFYEKILRDIIEnVEFDSVAFKDATGTANPNKIYETVKMARKLL--GRDVHIRLHTHETAGISVASYLAALEAGVDGI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7ANX1(2-266:538) Putative uncharacterized protein n=2 Tax=Bacteria RepID=B7ANX1_9BACE  E=1e-23 s/c=0.43 id=21% cov=44%
--KNISILDCTLRDGGRVINCEFSDDEIRDISRRLSDSNIDIVEVGFLRDSKKvHFEgnstfftDVNQIAPYLDkssgNCMYVAFIDYGMFDFD-TLGQCDGTSVDGIRV------GFTKKDYYSSRDDIIR----CLNIVKARGYKLFVQGVNSLSYSDKEMLDLVDLVNEVHPYSFGIVDTYGAMYEDDLQRIYALINNNMHK--DICIDFHSHNNYQlsFSLAQSIIRLSDSVRHiiIDATLNGMGKVAGNLNTELIV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7GH19(2-514:514) 2-isopropylmalate synthase n=98 Tax=cellular organisms RepID=LEU1_ANOFW  E=1e-155 s/c=1.07 id=47% cov=98%
--RKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKGDFQAVQAIAQTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPEQVVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDTVGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTINGIGERAGNAAIEEVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKNAFAHESGIHQDGVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLTEEEVNRLFVRFKDLADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAVVVLKDGeGNDIQEAATGAGSVEALYNALEKALQLPVTLLDYRIESVGSGRDALAQVYVKVSLDRKEASGRGTAQDVLEASAKAYIHAVNRMFVIEKMKEEQALAAQ---------
>UniRef50_Q2IUT4(10-519:524) 2-isopropylmalate synthase n=119 Tax=Bacteria RepID=LEU1_RHOP2   E=1e-155 s/c=1.08 id=46% cov=96%
--DRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYREMFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKLEELGYKLSRNQIEDVFVRFKALADRKKDVYDEDIEALVDEQLLHGQ-DQIKLNSLTVIAGTHGPQRATMKLDVDGQIRIEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQ-------------------
>UniRef50_D2M1E9(1-501:514) 2-isopropylmalate synthase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1E9_BACS4  E=1e-152 s/c=1.08 id=46% cov=96%
MS-KINIFDTTLRDGEQSPGVNLNQLEKLEIAKQLERFGVDIMEAGFPASSQGDFEGVRAIANTIKNASVTGLARAKKSDIDYAWDALKEAVEPRLHIFLATSPIHMTYKLKKTPEQVIQTAVDMVSYASKNFPHVEWSAEDASRSDIHFLVKIIEKVIDAGATVINLPDTVGYTTPQEYGDLFKYVRENVRNIDKVTLSAHCHDDLGMAVANTIAAVENGATQVEGTINGIGERAGNASLEEIAVALNIRSDKYPYTTNLVLNEIKRTSDLVSKLTGMVVPPNKAVVGRNAFAHESGIHQDGVLKNASTYEIITPELVGIQSNNLVLGKHSGRHAFKDKIEQLGYELAEDKLLEAFQSFKLLTDRKKEVTDDDLFTILTDIQtDTSDVKKYELEAFQVQYGSSNLPTATVALTTPEGERVETAcTGSGSVEALYNTLEALIKEKIHLTDFNLSSVGQGRDALADVHIKMTVNDTPVSGRGTAQDVLEASAKAFLNAVNRVF-----------------------
>UniRef50_O27525(12-502:505) 2-isopropylmalate synthase 2 n=22 Tax=Archaea RepID=LEU12_METTH   E=1e-143 s/c=1.04 id=42% cov=93%
LPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRRIVELGLEANICGLARVLREDIDAAID----CGVDYIHTFIGTSPLHREYKLKMSPDEIIDRAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAMNHLVSRLKEEL----RVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAALEEVVMALITRYD---LPVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIHVHGVLEKAETYEPITPEMVGH-KRRIVLGKHTGANALRSKLQEYGIEMKEEQFCTLYEQVKRLGDKGKRITDADLRAMAVTILGKASREIVKLEGIAVMTGESVMPTATVKLRIGDEVKTTSMTGVGPVDAAINAIQSLVSetADIELDEYNIEAITGGTNALAEVFVVMSDGeGNKATGRSTREDIVMASVEAVLDAINKIL-----------------------
>UniRef50_D0MYD7(32-565:576) 2-isopropylmalate synthase n=2 Tax=Phytophthora infestans T30-4 RepID=D0MYD7_PHYIN  E=1e-142 s/c=0.95 id=47% cov=96%
--ERLVLFDTTLRDGEQSPGATLNFKEKLDIARALSTLGVDVCEAGFPISSPGDFDAVSAIAKEIgpitagrptgEPMTICGLARAMEKDIQRCYDAVKHAPKHRIHTFLATSDIHLQYKLKISRDECIRRAVDAVKFAKSLTPDVEFSTEDAGRSDPDFLCDVLAEVIKAGATTLNIPDTVGYTVPGEYGSLFSYLIDNTEGSDKAIFSTHCHNDLGLATANTLAAVQGGARQAEVTINGIGERAGNTALEELVMALKTRPQHFPVYTSVDSTQITRCSRMVSHYTGMSIQPNKAIVGSNAFAHESGIHQDGVLKHQATYEIMLPESVGLSENKMVLGKHSGRHAYSKRLQQLGYTnLTPEELDYYVEKFKVLADEKKTVTDADMEAIVSDELF-KPETFWTLQSVHVTAGNLVKPTATVTLAHkDGQEVSEAAMGTGPIDAIYVAIKRATGMEsIKLNDFSVESVTDGTYALGEVTVRVQEDkeeeektegekhvnaqtgvtrDRQFVGHGANTDILVASATAYVNAVNRMMASQ--------------------
>UniRef50_D1PA75(13-518:532) (R)-citramalate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA75_9BACT  E=1e-115 s/c=0.83 id=27% cov=93%
--KEIEIMDCTLRDGEQTNGVSFLPHEKLMIARMlLHDINVDRIEVASARVSEGEKDAVARICRyaktigKLDSVEVLGFV-----DNNKSVDWIAECGGHVINLLAKGSYKHCTQQLKMSPEEHLAHIKQTIGYALSKGFTVNLYLEDWSsgmRDSRDYLFMMMDELVKQPIKRFLLPDTLGILNPLQCVEYMRQMVRRYPNSH---FDFHAHNDYDLAVSNSLAAVLSGAKGLHVTVNGLGERCGNAPLASVQVILK---DMFEAKTNIKEDRLNDISRLVEGYSGIAVAPNTPVVGDNVFTQVAGVHADGDNKDKLYCNDLVPERFGRHR-EYALGKNSGKANIVQNLNELGLELTPEQTKAVTKRITELGDRKELVTQDDLPYIVsDVLKHGAPEDKVKLVSYMVSTSYGLKPIASVKVEIEGKEYEDQSSGDGQYDAFVKALRNIYKVKlgktfPKLDNYQVTIPPGGrTDALVQTVITWREGDRIWRTRGLDADQTEAAIKATLKMIN--------------------------
>UniRef50_A8ZTR1(2-525:542) 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Bacteria RepID=A8ZTR1_DESOH  E=1e-115 s/c=0.80 id=30% cov=93%
--EQVRIYDTTLRDGMQGDTINFTVDEKIRVARQLDDLGVHYIEGGWPGSNPRDVQFFEKAAKiDFKNARLTAFGSTRRAGLavekDDNIRLLLECGAPAVALVGKTWDLHITEVMSNTLESNLEMIHDSVAYVKSHGREVFFDAEHFFDgctHNREYTFKAILTAAQAGADAVILCDTNGGALPHDVeaitAEVCTTLADRFPGPDGgstVQVGIHTHNDSNLAVANSIAAIRAGARIVQGTINGYGERCGNADLTSIIPILAAKMEYDCI-TPENLKKLRKVSRFVSETANMTPVNSRPFVGKSAFSHKGGLHVSAIMKNPRAYEHMDPELVG-NKRRVLISDLSGRSNVTYKARELGINTDTEhfDVDRILSEVKML-ELEGFQFDAADGSFKIVMEKISglYTPLFDLLSFRVTvekeKDRPCTAHATIRLGVGELETTTAAEGDGPVSALDTALRMAIAEfypdslgldAMQLVDFKVRVLDGrdGTSAKVRVLIDSRDEDEVWGTIGVSEDIIEASWEAL-------------------------------
>UniRef50_A5VPL4(104-624:640) 2-isopropylmalate synthase/homocitrate synthase family protein n=151 Tax=Bacteria RepID=A5VPL4_BRUO2  E=1e-112 s/c=0.78 id=29% cov=94%
MAReRIYIYDTTLRDGQQTPGVDFSVEDKKSIVTLLEELGVDYVEGGYPGANPTDTAFFKR--RQTARAKFVAFGMTKRAGVsvsnDPGLSSLLQASADAVCFVAKSWDYHVRLALGCTNEENLESITASVTAARMAGREALVDCEhffDGYKANPEYALACAKAAYSAGARWVVLCDTNGGTQPLEVAAIVEAVKAVVPGES---LGIHAHNDTEQAVAVSLAAIDAGVRHVQGTLNGIGERCGNANLVSLIPTLVLKpYWAERFELGIKpasLKSITRISRAFDDILNRPATEQAPYTGTSAFATKAGIHASALMKEPQTYEHIPPESVG-NSRRVMVSDQGGKSNFIAELERRGIRVakDDVRLDTLIALVKErEAEGYAYEGADASFELLARGMLNPQPEFFKVESFRclverrfdANGMLKTVSEAVVKVEVDGEMHMSVAEGHGPVNALDIALRKDLGcfqaeiEDLELVDFKVRILNGGTAAITRVLIESGDAtGARWRTVGVSDNIIDASFQALMDSVN--------------------------
>UniRef50_A4QAP0(72-610:616) 2-isopropylmalate synthase n=225 Tax=cellular organisms RepID=LEU1_CORGB  E=1e-112 s/c=0.75 id=26% cov=94%
---------VDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKdmiPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATDAAELIKTIAQDYpdtnwrwQYSPESFTGTEVEYAKEVVDAVVEVMdptpenPMIINLPSTVEMITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQ----GVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYAGDLVFTAFSGSHQDAVNKGLDamaakvkpganstdvsweelrdtewevPYLPIDPKDVGRDyEAVIRVNSQSGKGGVAYIMKtDHGLQIPRSMQVEFSAVVQNVTDAEGGEVNSKAMWDIFATEYLERTAPVEQIALRVENAQTENEDASITaeLIHNGKDVTVDGHGNGPLAAYANALEK-LGIDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVNR---ALDVNHE---------------
>UniRef50_Q57926(22-398:398) 2-isopropylmalate synthase 1 n=16 Tax=Euryarchaeota RepID=LEU11_METJA  E=1e-109 s/c=1.06 id=40% cov=69%
----IYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIANEGLNADILALCRALKKDIDKAIE----CDVDGIITFIATSPLHLKYKFnNKSLDEILEMGVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSMEFICKTLKENLK---KAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAALEELIMALTVLYD---VDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHVDAVIENPLTYEPFLPEKIGLKRN-ILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKVKEIREEGKFITDE------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1N7Y9(25-566:567) Pyruvate carboxyltransferase n=2 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7Y9_9BACT  E=1e-108 s/c=0.73 id=23% cov=94%
-----VWASVDLRDGNQALPEPMGPEHKLEYFNMLVGIGFKEIEVAFPSASADDFNFVRMLIERnliPDDVRISVLTQARRHLIDRTIESLRGVKHAIAHCYVPTSDLHGRFVFNHNREEVKQMAVDGTRMVKEAIEReglwgkvaYEFSPEEFTDSDLDFVVEVCCAVKEVWGPstpdmlILNLPATVERRPPNQYADMIELFCRKFPYLNEVGLSLHAHNDQGCAVAATELALLAGATRVEGTVFGHGERTGNLD----VSVLALNMESRGVRTGLNFSNMPEIVRIVERNSGIEVHPRHPYAGDLVFTAFSGSHQDAIRKGFEHraeiseffrqgwkipYLHLDPADLGRQYEKlIRINSQSGKGGVVYVLEkEFGVYPPKTMHPEIGAVVQKVVDAEGGEINSADLKRIFYDNFVNAEGPYRMENYQ-RASVGDRSGSNFSWFINGEKHELSGQGNGPLSAVVHALKSSGLMPfFKLEDFSERTLGKDADAKALAFVGLRCGEDSehtslVYGAGEHSNIDRAAIAALVSAMNRAVA----------------------
>UniRef50_Q0EZI5(8-533:543) 2-isopropylmalate synthase n=1 Tax=Mariprofundus ferrooxydans PV-1 RepID=Q0EZI5_9PROT  E=1e-106 s/c=0.74 id=26% cov=94%
--RRIQLYDTTLRDGAQSAGIHFSAEDKKRIARRLASFGMDWIEGGWPGASPTDDCFFELMRDRaWSHSRLVAFGSTARPGhpasEDPGLARLVACGADAVCIFGKSWDLHVTTGLGIDLQTNLDLVRESVAWLKLHVDTVLFDAEhffDGYAANRDYAMQVLAAAADAGADSLVLCDTNGGSLPEQIGACVRQVVARYPDLT---IGIHAHNDSEMAVANAVSAVSAGASHVQGTINGLGERCGNTNLISVIPVLKLKMGVNCGVSTESLRKLRRLSTFVNEMANQLPWQHQPFVGQNAFAHKGGIHVSAVRKASHLYEHIDPASVG-NAQRVLVSNQAGRSNILAKLQQLEPDaiVDDAAVVRAVQRIKEMeATGYAFEGADASFQLLLRRATGQFRRHFELVSFRVYDEKRGHdeapeSEATVQVRVNGRLLHTAALGSGPVNAMDKALRAALTgaypglEDMRLTDFKVRVLStkDATEAAVRVLIESSDGVRKWNTVGVSTDVLEATYRALNDAI---------------------------
>UniRef50_Q5KCL7(31-625:639) 2-isopropylmalate synthase, putative n=1 Tax=Filobasidiella neoformans RepID=Q5KCL7_CRYNE  E=1e-104 s/c=0.64 id=24% cov=93%
-----IWLSTDLRDGNQSLANPMTNQQKLRFFRHLVQLGFKEIEVAYPAASETDYNFVRELIDRkevPDDVWIQVLTPARADLIKRTFEAVAGLKHVIVHMYNATSCLFREVVFNNDRDETIKLAMDHTilirqlaeKYAESHGtsFRYEYSPETFSQTETPYAVEVCEAVKKAwlgghgsvWADgrkeeriIFNLPATVEVATPNCFADQVEIFCNSISEREKCIISLHTHNDRGCAVAAAELGVLAGADRIEGTVLGNGERTGNVDL----VTLALNCYSQGISPNLDFSDMFSVIDTVTECTGLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEaqakrdhagdqvwsmPYLPIDPADVGCTyEAVIRVNSQSGKGGIAYIVKSaLSLDLPRRMQIAFYKVVQECSEATGREMTSKDITTAFRQTYHLggsiYDGRLVLKSFVTVDlfssqtpsvaGTPDLSPIrsrsqtrmpplslsssvaepspdrsldrnlpsmskrlTAKVLVDGKLHEIVGEGNGPLSSFLNALESDLGIVLSVREYTEHAVGAGSDVKAATYVElipanVDAKDKTqggFWGVGVDADITASGLKAVVSAAN--------------------------
>UniRef50_C9RKZ6(4-518:518) Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKZ6_FIBSS  E=1e-100 s/c=0.71 id=34% cov=94%
-TRKPFFYDVTLRDGNQALPKPWNNAQKKDVYLLLLKLGVQGAEVGFPASSEMDFESVMELAKLtaqmaeegdevAKNVVVSGLARCIESDIQRCWEAVQYAPHPRIHTFLATSPLSMENVLHMTPEQVKEKAVKCVKFAKSLVgdrGDVEFSAEHFGDCleNMDFVIDVLKAVVEAGATTINLPNTVERYRPKLYVDQVKQVYEALPK--NITISVHCHNDLGMATAATVESFFVGATQLEVALNGLGERCGNTNFYEVAIGL----HNSGVDTGLHLERIYETAILVSHWSGVPIYIRAPLIGTEAIVHRSGIHQDGASKTKDMkkgaYRPIDYSIIGRNQNDtLSFTSQSGRTAVYEIITKFGYKMTLQEASKLQPVLKRLSEAEG-ELSAERVLDVFREQFVNVNGRLVFNNIEVIPDEN---RFIFHFKKDGEALVKSVTAEGPIEAALMLMREI-GMPVELVKYRQLVVPEKDklwAGRGLSRIVLKANGEEVEGRGVSSDTLKANMRALFGGVNLIYKKA--------------------
>UniRef50_Q6L0K4(27-373:386) 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6L0K4_PICTO  E=1e-100 s/c=1.06 id=40% cov=67%
--KRIRIFDTTLRDGEQSPGVSFNINQKARIAGMLVDLGVDMIETGFAAVSSEESMAIRKIHEMDGN--FISLARCNRHDID----SVIDTGIDNIHLFIATSDIHIKYKLKTSRENIMEKIVDSIDYARSHGLNVLFSPEDATRTDMNFLIDVINTAISSGAYEINIPDTIGIMNPISMYNFIHEIKNR----TKSCISVHCHNDFGMATANTLAAIMAGADGAQVTVNGIGERAGNAALEEVVLSVHAFTD---CSTGINMRMIPKISKYVSMASKMYIQKNKAIVGENAFSHESGIHVHGLINNPETYEPIDPGILGLNRR-IVLGKHSGTTSLKYILESHGIKKSDDEISGILVRIKDM----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5S831(21-530:534) 2-isopropylmalate synthase n=20 Tax=Bacteria RepID=C5S831_CHRVI   E=2e-99 s/c=0.72 id=28% cov=93%
--RRVLIMDTTLRDGEQTQGVSFAPAEKLNLAKvLLEQVRVDRIEVASARVSSGEASAVAQIIDwarergLVERVEVLGFV-----DGGASVDWICGAGGQVLNLLAKGSEKHCRGQLGKTLDEHAADVRATIAAAQSRGLRVNLYLEDWSngyRDNPDYVYGLVERLADVGIGHFMLPDTLGVMTPDQV---FTAISDMVGRFPSLQFDFHPHNDYGLATANVLAAVQAGAAAVHCTVNCLGERAGNASLAEVAVNLR---DQLDCALGIDETHLARVSELVESFSGKRISDNAPIVGADVFTQTAGIHADGDKKGSLYHSRLSPERFAR-RRKYALGKLAGKASLAKNLERLDIELSEENQRKVLQRIVELGDSKKTITTEDLPFIIAEVLESKDYDHAELLSCTVSSSLDLESMAGIRIRLGEQVFTGTGTGNGGFDAFTNALGRILKRQgltlPPLIDYEVRIPKGGrTDALTECSITWQTERGELRTRGVHANQVFAAIGATMRMLNiRMHRA---------------------
>UniRef50_P58967(23-405:405) 2-isopropylmalate synthase 1 n=9 Tax=Euryarchaeota RepID=LEU11_METMA  E=5e-98 s/c=0.94 id=35% cov=73%
----IEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVSADEKEIVKEIANQGFNSRICCLSRAVKGDVDAALE----CDVDIVSIFIAMSDMHLKYKYHRSLEDMLGCAKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVEnEYKVQYVSLADTVGILNPTTTNYLVSEIFKSV----NTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGERAGNASLEEVLVALRVQYGIE----RYDTTKLNSLSEMVSEYSGITPSVNKAVVGKNAFTHESGIHVAAILEEPRTYELFLPEMVGGKRN-LVVGKHTGKKALKGIINSIGFCLEREELCALIEKVKVCTEEKhKSISRDQLERLITQVKQEQKPSGSEKEKFSI-----------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1FHL1(64-631:662) 2-isopropylmalate synthase n=2 Tax=cellular organisms RepID=C1FHL1_9CHLO  E=1e-92 s/c=0.60 id=24% cov=94%
----VVCYDTTLRDGSQQVGISLTCDDKLAVAEHLVGLGVAYIEGGYPGSNPKDVEFFSRWTSSGLadraaagGTKLAAFGMTRRrgvtADDDEGLKALTDCPAPCVCIVAKAWDEQCEKVLGVSPEENIAMIEESVAHLVAAGKEVLVDCEHYFdgrKANPEFAVKCAAAAAKSGAKFVVLCDTNGGTLPWDVEEFTREVKEAVDATGaDCSVGIHCHNDTSLAVANSIAAVRGGATMVQGCVNGYGERTGNADLLVVAANLELKMGRTALPEG-SLQRLTQVSAAVAKLCSQHQDPRQPYMGSSAFAHKGGLHVAALQKMPASYNHIVPTLVG-NEARSVISELSGRGNILSAAMASGREVSKETAAQVLSQIKDL-ESRGFVLEDagASVDILFRRADPNYRAPFNVLEFNVTASNSSFGGFTPNdLLVGGDERLQdvlpedeleapfthpqqagykkgsvavnqvvvkvdvfdndttpasrntqlcVAEGNGPVNALANALRLSLTdkfpqlKQIHLQDYKVDLLSTAGTSAAVTRVTMDFADRdtdiTWRTVGAHASIIEASFRALVDGM---------------------------
>UniRef50_B9LUZ7(10-387:387) Pyruvate carboxyltransferase n=1 Tax=Halorubrum lacusprofundi ATCC 49239 RepID=B9LUZ7_HALLT  E=1e-89 s/c=0.88 id=39% cov=72%
----VRIFDTTLRDGEQSPRTSFSYDEKRRIAATLDDMNTHVIEAGFPVNSDAEFEAVSDIAAAT-NTTVCGLARVVEGDIDAAID----SGVEMVHVFVSTSDVQLEDSMHATRQEAKQRAVAAVEQVKDAGVECMFSPMDATRTDPDYLREIVEAVSDAGTDWINIPDTCGVAMPTSFGKTVKAVV----NATDARVDVHTHDDFGMAAANAVMGFENGAEQAQVSVNGIGERAGNAAYEEVVMAVES---VYGVDTGIDTTQITKLARIVEEASDIPVPANKPVTGRNAFAHESGIHAAGVIENADTFEtgVMTPEMVGA-EREFVLGKHTGTHSVRKHLVEAGFDPTDSEVRRITKRVKEYGSGKRQVTAGDVERFAEEADIDREEEEVR-----------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9V1J1(2-345:361) 2-isopropylmalate synthase 2 n=5 Tax=Thermococcaceae RepID=LEU12_PYRAB  E=8e-87 s/c=0.94 id=31% cov=63%
------VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAHSRALIEDIDYVLK----TGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIK----KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGR-ERTIYVDRYAGKDTIRYYLEKFGI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9A1L0(24-372:393) Pyruvate carboxyltransferase n=6 Tax=Thaumarchaeota RepID=A9A1L0_NITMS  E=3e-86 s/c=0.92 id=29% cov=66%
-PKKIRVLDSTLREGEQHPGVSFTNKQRIQIAWMLDYFGVDQIEI-SPVVSNDHKEATKTIIKQGLKADIVSHGRALKEDIDVSLD----CDAKWCAAYLGISDIHLKDKLRISREDAMERAVETVEYAKSHGLKIRFTVEDGSRAEPEFLLKVCKAIEEAGVDRISLPDTVGILRPIGMYNFVKKVRDSI----DVPLDAHVHNDIGFAVANAFSACDAGVDQIHTTIDGIGERTGIPPLAEVAVALTYLYKSPN---DFRLDMLLDLSRLIEEYTTIKPYDSKPIVGSSAYKHKAGTHLAAILRNPAAYEPIPPRAVG-NRRRIVFGELAGKTGAAYLMSLLGLDKDDESAKAV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0ZQ46(1-362:373) FrbC n=3 Tax=Bacteria RepID=Q0ZQ46_9ACTO   E=1e-83 s/c=0.86 id=30% cov=65%
MRNDLVLEDTTLRDGEQTPGVAFSKETKTAILNALIEAGVTSIEIGIPAMGGEELDFIKSVVDRQDEARLVVWHRGVREDVERSLDL----GFTSVHVGLPTSAGHLKASVRKDRTWLLATARDMVKMAKDRGAFVSISAEDIARTEISFLQEYAGVVAEAGADRLRLSDTVGLLGPEAYGERVAAVLSA----ADIDVQCHAHNDFGLATANTLAGLKAGARYFHVTVNAIGERAGMADLAQVVVALKKLYDR---DLGIDLTKLKKVSRLVAEAAGHQVLPWQPITGDNVFAHESGIHANGMFRDTSSFEPFPPEHVG-GERRYVLGKHSGRALVAWALEQEGITPREE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2GMU3(52-562:828) Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GMU3_CHAGB  E=1e-76 s/c=0.57 id=26% cov=67%
-----RWLSTDLRDGNQALASPM----------MLVDIGFKEIEVGFPASSEMDFQFAQRcVLDGPPDVWLEVMTPCRKDFIRRTVDAVKGAKKIIVSLYIATSDNFIDTIFSTTREAQLRTAVEHARYLKTVTKDdpahkdttwaLMWSPEAFSDTDPDFAIEICRAVKEAWEPsaevpiILNLPATVEMSSPNIFADQVEIFSRGFSGDPTVCVSLHNHNDRGCAVAAAELGQLAGATRVEGCLFGNGERTGNVDLVTLALNLYTQ----GIDPGLDFSDLPRIRRIVEQLTQIPVHTRAPYAGDSVFVAYSGGHQDAINKGFKrwnatanddkhgrprpwkvPYLAMDPHDIGASyEAVIRVNSQSGKGGIAWVLSQaLQLEAPKAILGAFSLAVKSESELKGR----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q01181(19-383:391) Homocitrate synthase n=27 Tax=Proteobacteria RepID=NIFV_RHOSH   E=3e-76 s/c=0.79 id=32% cov=63%
----VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAVLKTAAPVVWCRLRAED----LAAAQRTGVVRLHIGVPVSERQISAKLGKDAAWVRDKVEKLVRAASWAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGVLDPFAAHELVGRVVTRCP----LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNAA----LEEVAAALEAAGRATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVDGLMKDRATYEsaDLRPERFGRS-HRIAIGKHSSAAGLARALAEAGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0AC93(6-362:397) Trans-homoaconitate synthase n=2 Tax=Opitutaceae bacterium TAV2 RepID=C0AC93_9BACT  E=2e-70 s/c=0.75 id=34% cov=67%
-PHRLHLIDTTLRDGEQAAGVVFSQADKLAIARALVEARVPELEVGIPAAGAGAIDDINAVADAVAGrARIITWCRALPGDIALA----RACRVTGVHLSFPVSNIHMR-IWGATPATVLASLDELTAAAREHFDQVTVGAQDASRADPGFLAEFAAAAARTPAVRLRLADTVGFLTPDKTAGLTSHLRHAAPAL---PVEIHAHNDLGLATANTLAAFSAGASAASLTVNGLGERAGNAALEEVVMALKVAQ---GIDCGIDTSRFVELSALVARASRRPVPVQKPVVGAGAFLHESGIHCAGLLRDRRSYEPFDPADVGHAASDFVLGAHTGGAAVAAALATCGVTLAKTEARHLAEEV-------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1XGU5(19-412:422) Isopropylmalate/homocitrate/citramalate synthase n=2 Tax=Meiothermus RepID=C1XGU5_MEIRU  E=1e-66 s/c=0.65 id=28% cov=67%
---RIEIVDTTFRDGQQSPllfdteKYRFTLEEKKVLMTGLLELGVTHFEFFSPVVGVAEAQDVRELIAHAsaltqKPLRFLAHCRCNLQDIEQALE----TGCNGLNLYLGVSPLAQQHNAQKSLEESVQLVQEVIATTRAAhpDLYIRFSAEDAFRTPLEDIFRLYDAIYPY-VNTLGMPDTVGIAEPEDVSAVVAQLRQRYPN---VALECHFHNDRGLALANVIAAVRAGVRYVDASIWGLAERSGIPSVTGVLFNLSKRYPE--IAQQYNLSQCYPLNVLMASILGTLVPYTEPVSLTNR-THTAGVHQKAVLNEKKVYEAHNLHDFGVDKNQLLLGPLSGWNLIYYYLKEVeGFVISKEQAKQIAQEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q46A98(8-283:287) Homocitrate synthase n=2 Tax=Methanosarcina RepID=Q46A98_METBF   E=5e-64 s/c=0.89 id=30% cov=53%
------IIDTTLRDGEQSAGVVFSVEERMNIISALDKAKVKWIEAGIPAMGKQECEDLKLMLNLPIKSNLIAWNRANLEDLKASID----CGFKFVHVSLPVSDLHIEHKLQKSRTWVLDQLKKCMEYLQSCKVTIIVGAEDASRADPEFLLQYAGIAASYGAIRIRYSDTVGCLDHFTTYRKIKEIADHSPP----PVEIHAHNDFGLAVANTLAAYKAGAKFASVTVTGLGERAGNASMEETAFSLK---RFYNYDCGIELEALPFLAEMVSKASERTLFPYKPLVGSLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1DCT2(30-410:421) 2-isopropylmalate synthase/homocitrate synthase family protein n=3 Tax=Myxococcales RepID=Q1DCT2_MYXXD  E=3e-60 s/c=0.62 id=29% cov=67%
----VEINDETLRDGMQATAVtSPTVEEKRGLLELMQHIGVSAVSLGMPAAGPWALEEVvtlaRHIREEALRLEPNCAARTLHSDIVPIVEAVQRAGQPiVVHTFIGSSPL-RQCAEAWDLDFILRSSTAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATPAGTRALVRWTRDLVERLGSpVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERTGNAPVELLLLNLKLLGWIDQ-----DLTRLVDYVLTLAQVCRVPIPRNYPLVGEDAFRTATGVHSAAIIKALERgddwladhiYSSVPAGEFGR-RQQLELGPMSGMSGVRYWLMVRGLQENEQLCEEILRRAK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7IGD9(1-251:274) Homocitrate synthase n=1 Tax=Clostridium papyrosolvens DSM 2782 RepID=C7IGD9_9CLOT  E=4e-58 s/c=0.91 id=31% cov=46%
MKEKKYIIDTTLRDGEQTPGYAFSKAQKVELAKVMDDAGIYQIEAGIPAMGNYEKETISEIMSQRKNALISTWNRMSRDDINNSFD----CHPDIIHITAPISYIHIYSKLNKNKKWLRNTLQECVFMAKDKGYEVTVGFEDASRADITFIISMANLLADMGVKSVRFADTVGVLTPARTYQCIREIKENV----DIPVGIHAHNDLGMALANSLIAAKAGALYIDTTIGGIGERAGNCDLYQFILA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4B8D2(4-274:277) Pyruvate carboxyltransferase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4B8D2_9CHRO  E=6e-57 s/c=0.83 id=45% cov=46%
LSEQILILDTTMRDGELVPGIKMSQAEKLRLAQLLEEAKVDIIEVSYPAKSQQDFDEIVAVSREIKNSIVCALSNLSVQEIERAATGLKSASRGRIHLY---SNVNLAKKEPLKRQEALSMIQQGVTLARNYCDDIEWSAFDASRSDLDFLCRGIEMAINSGAKTINIPDSLGVLLPAEFAQLLEKIFTRVPNIDKSIVSVHCHDDCEQALLNSLIALEVGVRQIECSLNGLGARKGNANLKSVI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8MB07(2-339:355) 2-isopropylmalate synthase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MB07_CALMQ  E=4e-54 s/c=0.64 id=26% cov=63%
------IIDDTLREGLQAPGISFTVEEKIELAKLISNAGVDEAIVSHPSAHESEVEVTRIIVERNYFKYVFGLGRALKEDID-----LIASTGANISTYIPFEPQLVNK--------SLDVIKYAVNTYGKGKLIIEVGITNITAYELSNIVKLAKTLEELGVDRIQLADSLGKATPKLMYNIVNNVKHTV----KIPVSVHCHNDMGAAVANSISSVYAGADYVDATIYGIGERNGIADLATIAMILR----NDSYRINIDFEKLRDAYNYLAKLIidKIDIeffRNNFPVFGNNISIQTAGTHAAypGVFKE-----------VG-----YSLNVYVGRSTLRKVLSELGISLNDQELLMLMRKIKDTAVRTGRAVTYD-----------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O81027(164-448:468) Hydroxymethylglutaryl-CoA lyase, mitochondrial n=76 Tax=cellular organisms RepID=HMGCL_ARATH  E=1e-53 s/c=0.75 id=23% cov=49%
------------RDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATsfvSPKWVPQlaDAKDVMDAVNTLDGARLPVLTPNLKG-----FQAAVSAGAKEVAIFASASESFSLSNINCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEgpvlpsKVAYVVKELYDMGCFEISLGDTIGIGTPGSVVPMLEAVMAVVPAD---KLAVHFHDTYGQALANILVSLQMGISIVDSSIAGLGgcpyakGASGNVATEDVVYMLN----GLGVHTNVDLGKLIAAGDFISKHLGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5T2M7(59-349:358) Pyruvate carboxyltransferase n=1 Tax=Acidovorax delafieldii 2AN RepID=C5T2M7_ACIDE  E=3e-53 s/c=0.73 id=21% cov=53%
IPSRVKLIDVGPRDGLQNEKSPVPAEVKIGLVHRLQDAGLKNIEVTsyvSPKWVPQMADnhEVMSGIARQSGVVYSVLTPNLKG-----FEAAVLDRPDEIVVFGSASEAFSQKNINCSIAESIERFAPVVEAARAAGIHVRgamsctVGCPYEGEIAPERVAYLAGLMKQIGVQHIGVADTIGVGTPRKVQRAVEATLQHYDLND---ISGHFHDTYGQALANTLATLEMGVWQYDTSVAGLGgcpyakGATGNVATEDVVYML----HGMGIETGIDLDKLIDAGAYISGFLGRKPNSRAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0SA13(2-298:299) 2-isopropylmalate synthase n=5 Tax=Leptospira RepID=B0SA13_LEPBA   E=3e-53 s/c=0.71 id=25% cov=50%
--EKVKITEVGPRDGLQNEKTILSTQDKFEFIKRLVESGAKHIELTSFVrkdRIPQMADAMElsalVLPLYAKDVQFSCLTPNTKG-----YEGAKLAGFNEVAVFTATSESFTKKNINMTVKESFESFQPIFGLAKQDGIKVRGYistvvaCPYEGKIPPEKTLEVAERLLDAGAYEISLGETIGVAVPNEIESLLSVLLKKIPISY---LNCHFHDTYGMAIANTKQALSMGIRSFDSSAGGLGgcpyakGAAGNVATEDLVYFL----SREGYDTGINLDSLIQVSQFME---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q146L0(3-287:309) Hydroxymethylglutaryl-CoA lyase n=18 Tax=cellular organisms RepID=Q146L0_BURXL  E=2e-51 s/c=0.72 id=23% cov=51%
LPQQVKIVEVGPRDGLQNEKEFVPTATKIELINRLSAAGFRNVEAAsfvSPKWVPQMADgaDVMAGIERRPGTIYSVLTPNLRG-----FEGALAARADEIVIFGAASEAFSQKNINCSIAESIGRFAPVAQAAKEHGVRIRGSVSCALGCPYQgevpvaSVVDVVERFAALGCDEIDIADTIGVGTPKRTREVFEAVTRVFPRER---LSGHFHDTYGQALANIYAALLEGIEIYHASVAGLGgcpyakGATGNVATEDVLYLMN----GLGIETGIDLAQVVAIGDFISTSIGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2C751(11-302:313) Putative hydroxymethylglutaryl-CoA lyase n=3 Tax=cellular organisms RepID=Q2C751_9GAMM  E=2e-50 s/c=0.69 id=22% cov=50%
LPDAITVFEVGPRDGLQNEPHLSTlggkaTALKIALINELGQTGLTHIESGafvSPKMIPTMADSdiVFSHIQRHPNIFYSALTPNL-----QGLEAAINVNANEVAIFTSCSETFTQKNIHASIDESLQRFESVIAIAHQHLIPVRAYLSCVIDCPYEgktlpqQVAEIAKTLIDMGCYQVSLGDTIGTGTPLRVANMLEYVNKHI---QSKAIAVHFHDSYGQALANIYQAIQMGITTIDSSIAGLGGCPyapgssGNVATEDVIY----LCQGLNIKTGIDLEKLTLISQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0CWY1(8-292:552) Hydroxymethylglutaryl-CoA lyase, mitochondrial n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CWY1_ASPTN  E=3e-50 s/c=0.71 id=20% cov=50%
----VRIVEVGPRDGLQNIKDPVATSVKLELIRRLRESGLSTIELTsivSPRAVPQLADCREVLRDqtikqlqQHDGLRFPVLVPNPKG-----LDIALEYGVKEVAVFVSATEGFSKANINCSVGEGIERASRVAEKAIRNGVAVRGYVSCIFEDPfsgptkPSAVLRCVKALLSMGCYEVSLGDTTGVGRPETVRELLTYLVDN--SIPVERLAGHFHDTYGHAAANAWEAYTCGIRVFDSSVAGLGGCPfapgskGNVATEDLVFM----FHNAGVDAGVNLLKLMETGIWISRILG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q00853(3-256:269) Homocitrate synthase subunit alpha n=8 Tax=Clostridium RepID=NIFVA_CLOPA  E=8e-50 s/c=0.79 id=34% cov=46%
----INIVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGGDEKISVSKIAALGLPSKIAAWNRMSTKDIDTSIE----CGVDIVHISSPVSDLQIKTKLEKDRKWVAENLKRTVIYALEKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKELYSQIKKIRDKVP----IDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAGNCDFLKFVKVIQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1WEM7(13-298:332) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WEM7_VEREI  E=2e-49 s/c=0.70 id=24% cov=48%
--RRIALHEVGMRDGLQAETAFVPTDEKIALIDALADAGMRKIEATafvSPQAIPalRDASAVLRAIGRRPGVIYSALVPNA-----GGAERAIDAGADELNLVMSASESHNLANLKMTRAQSFEALSGVSRIARQARVRVNISLSCSFGCPMEGdmseatvLDGCARFIEQFGAQGVTLCDTTGMAYPGQVFALTCALRARWPGTE---LTLHFHDTRGMGLANVMAAIDAGATHFDVSLGGLGgcpyapGASGNVCSEGIAHAL----ECMGYDTGIDLALL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6GLP1(6-295:313) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Limnobacter sp. MED105 RepID=A6GLP1_9BURK  E=6e-49 s/c=0.68 id=22% cov=49%
LPGRVTLVEVGPRDGLQNEKTPISTAIKIELCKQLIEAGIHRLEAAafvSPKWVPQMADGADVLAGLQalpelqdRTVSYSALVPNLKG-----MEAAIEAGVQEAVVFTAASEAFTQKNINCTIAESIERFKPVAELARAHNIHlrgsisCALGCPYQGEVPVQSAAEVALRLRDIGVQEFDVADTIGVGTALRVSQVFEAVGYSVGLQN---VAGHFHDTYGQALANILAALQLGVSTFHSSIAGLGgcpyakGATGNVATEDVVYLL----QGMGIETGLNLNKLVQT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6HNN3(9-294:601) Pc21g09480 protein n=22 Tax=cellular organisms RepID=B6HNN3_PENCW   E=1e-48 s/c=0.69 id=23% cov=43%
----VRIVEVGPRDGLQNIRDSIPTSMKLELIKRLEETGLGTIEltsVVSPRRIPQLADCRDVLGDEgirrmgGKDLRLPVLVPTAKG-----LDVAIEYGVKEVAVFISATEGFSKANINCSVEQGIERARDVVSLALKSNTVVRGYVSCIFADPYDGptqpasVLRCVKELLDAGCYEVSLGDTLGVGSPSNVRSLITFLLDN--DIPGEKLAGHFHDTYGQAVANVWEAYKCGLRVFDSSVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1YPG1(1-287:304) Hydroxymethylglutaryl-CoA lyase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YPG1_9GAMM  E=2e-47 s/c=0.67 id=23% cov=52%
MSETVVITDVGPRDGLQNQPQVLSVEQRLQLVNAIADCGVPQIEVGS-FVSPKAVPAMAgtgQVFSALDAAEFVTPTIALIPNMK-GYELARESGVKTVTMVVYASDGMAQKNVGMSMAEAELVTLDILKLAKEDGIEviatiaVAFECPFDGATDPAVVKNIVAKFLAAGADQLVLADTVGAAHPQQVRELTATL---VASHGAEQLGCHFHDTRAMGLANVYAAVESGIRRFDSSIAGLGgcpfspGASGNVATDDIAMML----QQMGFKTGIDLGKLMQASDLAQRLTGTAP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2S7Y3(8-293:311) Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=D2S7Y3_9ACTO  E=1e-46 s/c=0.66 id=26% cov=50%
-----------MRDGLQLEA-PVPLEGKLAMLEALVATGVRRIEVTsfvSPKAVPALADADQLAAELssFQGVHFSALVANARG-----ATRAVDAGVAHLEYVVSASDGHSRANAGRSTAEAVAAVGEIAALAHGAGGSLEVvvatawDCPFDGRTPIPRTVDVARAVVTAGADRLCLGDTIGTTTPMRVVQLLDAVRRACPG---VEVGVHFHDTRGTGQANALAAVQAGVTQLDSSVGGLGgcpfapGASGNIATEELVYML----EESGVRTGIDLDAVLAAARVTEQAVGRPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0T0Z5(1-288:301) Pyruvate carboxyltransferase n=3 Tax=Bacteria RepID=B0T0Z5_CAUSK   E=2e-46 s/c=0.66 id=24% cov=43%
MSRFIQIVEVGPRDGLQNEALSLPVDEKLALIRRLEAAGAKRIEVVSfvnPNRVPQMAgaeEIMAALKPDLEHSRI-GLVLNMRG-----WERCVAAQCDEANVVVCATDGFGLANQGTTATQQVDALAAIVERqAVEGGppitmtLSVAFGCPFDGEVSEDQVVAIVREAASMGVPEIAIADTIGVADPWTVRRRVEAVRAAAP---DVRLRLHFHDTRNTGLANAYAGVEAGVDVLDASVGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8FC60(7-330:339) Pyruvate carboxyltransferase n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FC60_DESAA  E=4e-46 s/c=0.58 id=23% cov=52%
-PKKVTVGDITVRDGFQHEEIFIPTDAKVWVAEQLILAGFKRIETtnyGPPKLMPQfkDADELtrrlrnsKKIKHLIDDVELTAIT-IREKAAERAIQAkLDGNGPDRILFMVSTSESHHKTNSGLSLDAYWKMCEEYIPKAHDAGLKVCgtvstiWGCPIEGPTELQKAVDFTKRWLDIGADDIEHADHDGSAPPNKVYDYFSLILDQIPDPSLHV--AHFHVTRGWGCANVLAALQAGITHYESTIGGLGGQPANfcdrvpvggtgkyyyedasivglISTEDMVVMM----DEMGIDTGLDVDRLLDIGRMMEKIIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2GBZ7(1-288:304) Hydroxymethylglutaryl-CoA lyase n=3 Tax=Bacteria RepID=Q2GBZ7_NOVAD   E=9e-46 s/c=0.65 id=23% cov=49%
MSRRISFVEVGPRDGLQNEKTLVSTADKLELVRLGLDAGARRIEVASfvnPKRVPQmaDAEAVCAGLPSVDSVSYIGLVLNGKG----AERAIATGRLHELGAVCVSTDGFAIANQGQTSDESLDVAKAIVGMARDAGLKgqatigAAFGCPFEGEVSEDRVVAMAASLAEADPIEVALADTIGVADPAHVSRLVRRVIEAIAPL---PVRVHFHNTRGTGIANVWAAVEAGASVVDAALGGLGgcpfapGAAGNVSSEDVVYML----HRAGVETGMDLSKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5A1I6(3-273:595) Pyruvate carboxylase subunit B (PycB) n=18 Tax=Archaea RepID=C5A1I6_THEGJ  E=3e-44 s/c=0.67 id=23% cov=39%
---KVDIIDTTFRDAHQSLiATRLTTDDMLKIAETMDRIGFYSMEV-WGGATfdvcirylkEDPWERLRLLREHIRKTKLQMLLRGQnvvgykhypDDVVEKFVELAHKNGIDIFRIFDALNDVRNMEV--------------AIRKAKEVGAEVQGAIAYTTGkvFTLEYYMKKVEELLKLDVDVITIKDMAGLLTPWKIYELVSEIKETY----GIPVNVHTHSTTGMAVAVYLKGVEAGAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7NM88(19-302:508) Oxaloacetate decarboxylase alpha chain n=1 Tax=Gloeobacter violaceus RepID=Q7NM88_GLOVI  E=6e-44 s/c=0.64 id=22% cov=40%
-TSRVGVTDTTFRDAHQSlLATRMTTAQMLPVASRMNRIGFHSMEVWGGatfdacirFLGEDPWERLKVLRREMPDTRLQMLVRGQnllgyrhypDDIVERFIRRSVANGIDIIRTFDALNDVRNMRKTIETGKECGAHVQGTLVYTVSPVHDV------------DHYMAVARDLVAMGIDSLCIKDMAGLLKPDAAGRLVRALRPVVGTL--LPIQMHAHSLSGMASMAYWEAIQMGANAV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9A1R9(1-334:352) Pyruvate carboxyltransferase n=2 Tax=Archaea RepID=A9A1R9_NITMS   E=2e-42 s/c=0.53 id=27% cov=44%
MSKKVQILDTTLRDGSYSVNFSFTSSDTSIICSKLEKSGIKLIEVghglgfnasnsGYGKSTQSDEEYMIAAKESLSKSMYGMFCiPGIAKLSD--LELAKKHGMGFIRVGTDVTKVHQSEKF--------------IKKAKNLGFFVASNFMKSYVMPPDKFASIVKQSEEFGTDMVYIVDSAGGMFSSDLLEYYNSIR----NVSEIPLGFHGHDNLGMAISNSLYAADLGMEYIDSSLQGIGRSSGNACTEVLVMALK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q120B4(4-305:317) Hydroxymethylglutaryl-CoA lyase n=7 Tax=Bacteria RepID=Q120B4_POLSJ   E=9e-42 s/c=0.58 id=23% cov=49%
------------REGFQMEPKTYSLADRAALIDALAASGLKQIQVAsfvSPRAVPQMADTAElfAAIAKRPGTRYTALWLN-DNGFDRA-RACEQVDLDGKLMFY-TTEPFSQRNNNCSVAGMRERQLGWLDRYVALGIPVEkayvitaFGCNLGGAVPLSMVTDQVRWLVDACADRgvalpaVYLADTMGWANPEEIKRRIGAVREIVPDAS---IGLHLHDTRGVGGANIYAALQMGVRLFDSSVAGLggcpfaghqhGGAAGNICTEDMVFM----CQELGIETGIDLEALIEAARLAERIIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7GA98(650-928:1264) Precursor of carboxylase pyruvate carboxylase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GA98_PHATR  E=1e-40 s/c=0.61 id=26% cov=41%
----LLITDTTWRDAHQSlLATRMRTQELIksadytnmALANAfsLEMWGGATFDVAMRFLRECPWERLEALREKVPNVPFQMLLRGanavgytnyADNVVHKFCKQAHDSGVDVFRVFDSLNYI---ENLQLGVDAAGE-AGGFVEGAMSYTGDVA--DPTKGKYSLEYYMNLASELVDMGVHSLAIKDMAGLLTPKASTLLVSALREAHP---DIPIHVHTHDTAGSGVASMLAAAQAGADIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8KT71(5-258:312) MhpE-like protein n=4 Tax=Proteobacteria RepID=Q8KT71_PHOLU   E=5e-40 s/c=0.66 id=25% cov=41%
--------DVTLRDGGYLNNFNFTTEYAIKHVEALTKSGVEWFEIGYRngsfkpisnigltGMSPD--SYIRDIHQSVPEAKLVVIAHPHNINADDIY-AMKTNGVSLLRLCIKA--------------DNPQPCLELCEIARATGMAVGINFTRASQLSISKIIEIAKQCEQAGADIIYLADSNGSLFPEQVAQMFYKLKSA----TQVQLGFHPHDNLGLATANSIEAMRAGVNFIDSSLSGMGKGAGNLNLES----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8XJJ3(4-267:317) Pyruvate carboxyltransferase n=7 Tax=Actinobacteria (class) RepID=C8XJJ3_NAKMY  E=5e-40 s/c=0.64 id=21% cov=41%
------------RDGLQIEA-PISTAGKIRLLQALVATGVRRIEATafvSPRAVPamADAERIAEYVGTVPGVDWSGLVASPNG-----ATRAIGSGLRTIEYVVSAADGHSWANARRSTQDAVDAVAEVARIVHDAGGRLEViiatawDCPFDGPTDPQRTAGIAARALELGADQLCFGDTIGTATPARVRRLLDAVRaaiggPGDGGADPVALGAHFHNTRGTGIASAFAAVQAGIRQLDASVGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7LNE9(775-1055:1391) Pyruvate carboxylase n=5 Tax=cellular organisms RepID=A7LNE9_TOXGO   E=9e-40 s/c=0.59 id=21% cov=42%
--KRLLLCDTTLRDAHQSlLATRMRTIDMLKVAPsyahllptlfSMENWGGATFDVAYRFLRESPWRRLELLREAVPNIPFQMLLRgtnavgytaCPDNSVEAFCREAVKYGMDIFRVFDSLNFV---ENLKLGIDAAGAAGGVVEAAMAYTG---NVADPDRKPYTLDYYLELASQLVATHCHILCVKDMAGLLTPPAADLLISALRREFP---HIPIHVHTHDTGGCGVASMLAAAEAGADIVDVAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2A6U5(3-269:633) Conserved carboxylase region n=10 Tax=Bacteria RepID=B2A6U5_NATTJ   E=5e-39 s/c=0.62 id=19% cov=40%
----VKITDTSLRDAHQSLfATRMRTGDMVPILETIDNVGFHSLEMWggatfdscMRFLDEDPWERLRVIRKYVKNTKLQMLLRGQnivgyknypDDVLEEFIKKTVANGMDIIRIFDAVNDLRNMEK--------------AIEFTKREGAHAQGTI-CYTISPVHNnnvFVQFAKDLKETGCDSICVKDMAGLLSPYKGYDLVKRLKEEV----GLPVQIHSHSTSGMATTTYIKSIEAGADIVDTTI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6UE85(569-846:1184) Pyruvate carboxylase n=111 Tax=Bacteria RepID=A6UE85_SINMW   E=8e-39 s/c=0.59 id=25% cov=42%
--KEVLITDTTMRDGHQSlLATRMRTYDIARIADtyaralpglfSLECWGGATFDVSMRFLTEDPWERLAMVREGAPNLLLQMLLRGAngvgyknypDNVVKYFVRQAAKGGIDVFRVFDCLNWV---ENMRVSMDAVAEE-NRICEAAICYTGDILNSARP--KYDLKYYTALAAELEKAGAHMIAVKDMAGLLKPAAARVLFKALKEA----TDLPIHFHTHDTSGIAAATVLAAVESGVDVVDAAM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P13187(3-272:596) Oxaloacetate decarboxylase alpha chain n=404 Tax=cellular organisms RepID=DCOA_KLEPN  E=1e-38 s/c=0.60 id=18% cov=39%
----VAITDVVLRDAHQSLfATRLRLDDMLPVAAQLDDVGYRSLECWGGatfdacirFLGEDPWVRLRELKKAMPKTPLQMLLRGQnllgyrhyaDDVVERFVERAVKNGMDVFRVFDAMNDPRNM--------------QAALQAVRRHGAHAQGTLSYTTspAHTLQTWLDLTEQLLETGVDSVAIKDMSGILTPHAAFELVSEIKKRY----DVTLHLHCHATTGMAEMALLKAIEAGVDGV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0S6H7(3-285:289) Possible hydroxymethylglutaryl-CoA lyase n=3 Tax=Actinomycetales RepID=Q0S6H7_RHOSR  E=2e-38 s/c=0.58 id=24% cov=48%
----VTITDVVLRDGLQDEDVVVSTDHKIVVADALVAAGVKHIEAAsfvSPTRVPQMADADDVIARLPrtdPSVTYSALALNPRG-----VHRAIATGIDEIQVVTSASAGHSTANTGRNPDEALHGLAEALQKYPDRsflgGVSTAFVCPFEGIIAPAALVRVASAMAAMGVRRLGLADTLGTATTEQVLASAGAVRDALP---DVELSLHLHNAHGQALSTVIAAHrQLGITHFDSAIGGYGgcpfapGAHGNLATEELVAYLHAH----DIDTGIDQQAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0X8H4(536-791:1152) Pyruvate carboxylase n=24 Tax=Bacilli RepID=C0X8H4_ENTFA   E=5e-37 s/c=0.62 id=22% cov=42%
--ESVLMTDTTFRDAHQSlLATRVRTQDFKAIAGLTDAAlpelfssemwGGATFDVAYRFLTEDPWQRLRKIRQLMPNTLLQMLFRGSnavgyqnypDNVIEEFIKESARQGVDVFRIFDSLNWIPQMEKSI----QVVRDTGKIAEAAICYTGDI--NDPARAKYNVQYYLDMAKELENLGAQIIAIKDMAGLLKPQAAYRLISELKAA----TDLPIHLHTHDTSGNGIITYSAATKAGVDIVDVAM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4F0P9(8-242:352) 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Roseobacter sp. SK209-2-6 RepID=A4F0P9_9RHOB  E=1e-36 s/c=0.67 id=23% cov=42%
------VLDCTLRDGSYVIDFQFTSADTESIGGALDQAGFPYIEVGHGvgmGASETgnnvaaasDADYMAAAAKSVTSGKWGMFCIPGVANLDH-VRLAADHGIGFIRV-------------GTDVAQA-DSAIPFIELARKLGIEVFANFMKSYVLEPEAFGALAARSYDYGAEMVYLVDSAGGMLPHEVRAYLQAAKSAAPEL---PLGFHGHDNLGLAVANSLVSLEEGAAMVDTSLQGFGRSSGNTATE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0YTT0(7-259:681) Pyruvate carboxyltransferase n=1 Tax=Chlorobium ferrooxidans DSM 13031 RepID=Q0YTT0_9CHLB  E=6e-36 s/c=0.61 id=24% cov=44%
---HVDILDTTLRDGSYTIGYQFTADETALIAHGLELSGINYIEVGHGlglgadRAGKgaqavTDLVYMRACSNAIRRARFGFFYIPGIGEL-SDLKLLADEGGAFVRVGVSL--------------DAIDQACHAIREAKRLGLEVWANIMKIYAYSLKESREGSLRFVEAGADGVYVVDSAGGMLPSEVAEYVSEIRKEFTLAGvSARIGFHGHDNLSLSTACSLSAVGAGCDIVDGSLLGIGRSIGNAATEVLAMVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4TE53(524-818:1148) Pyruvate carboxylase n=40 Tax=Actinobacteria (class) RepID=A4TE53_MYCGI  E=5e-35 s/c=0.51 id=25% cov=42%
-SKAVGVTDTTFRDAHQSlLATRIRTSGMLMVAPYvarmtpqllsIECWGGATYDVALRFLKEDPWERLAALREAVPNICLQMLLRGRntvgytpypESVTHAFVQEATATGIDIYRIFDALN---NVDSMRPAIDAVRETGTAVAEVAMSYTGD--LSDPAENLYTLDYYLKLAEQIVDAGAHVLGIKDMAGLLRPQAADTLVRALRSRF----DLPVHVHTHDTPGGQLATYLAAWQAGASAVDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0MS84(2-267:528) Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MS84_9FIRM  E=5e-34 s/c=0.56 id=21% cov=37%
--KRIRILDCTLRDGGYINNWKFGYENIKDTVRRLIQAGIDIIEAGY-LSSKGDFsadesqyssvDAIKRILPAdRKNTLIAVMINCGDYDAELLPQ------------YDGTGPDCIRVCFHKSQAL---QAVELCRKIKEKGYKVYFQPMVALSYSDAEYLGLIGMANKFRPDGFYIVDSHGSMKQKDVARFFYLIENNLDK--EIAVGFHSHNNLQLSYSN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1AVP5(1-289:492) Conserved carboxylase region n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVP5_RUBXD  E=1e-33 s/c=0.51 id=22% cov=41%
MSGSVDIVDTTLRDGNQSLwsATGLTTQDVLAIAPTMDRVGFHALDFTSsthmgisvRFHREDPWERIRLVSAAMPNTplglittgmRFIRWVPAGEDLMRLAFRCWVRNGMRRIQIVDPSNDpGALLRMARIAREEGFEEVV--------VGLTYSISPVHTHEY---YLERAAAAARSEDIDRLYLKDPGGLLTPDAVRALIPGFIERFAPR---PVELHSHCTIGLGPLAYVEGLRSGVRILH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6LCK8(1-290:525) Carboxylase, putative n=7 Tax=Bacteroidales RepID=A6LCK8_PARD8   E=1e-33 s/c=0.50 id=22% cov=41%
MIRKLLIRDLTLRDGQQSAfATRMSQAQIDRVLPYYKDAGFYAMEV-WGGAVPDsvmrylgenPWDRLEIIKEKIGNsSKLSALSRGRnlfgynpypDEIIEGFCRNSIRSGIDIMRIFDALNDV---DNVKSTIRYV-KKFGGKADCAICYTIDPHHSPVERIKAalhgrplhkpvfTNEYFLNKALQLESLGADMITLKDMSGLIPPARTAELVRLFKKSL----KVPVDFHTHCTPGYGLASVVSAIINGVDIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7W8G4(1-276:484) Probable carboxylase n=3 Tax=Bordetella RepID=Q7W8G4_BORPA   E=4e-33 s/c=0.53 id=22% cov=37%
MSRRIGIIDTTLRDAQQCLwATRMTAGMMDPIAQALDEAGFDMIDFMAPVqfdvcvryLREDPFEKARHFRKRFRNTPmrsycrsksLVGFSMVPDDMVELWIDCLAANGFSAVGTLDSLLDVDNMKV--------------SVGRAKKIGIKsigALVFCESPLHTDALYAGTAAE-LVRCGVDGIMLKDSGALLTIERIRTLIPALRAAV---GDIPIEVHSHSNTGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2MHM3(1-147:157) 2-isopropylmalate synthase (Fragment) n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MHM3_9BACT  E=8e-33 s/c=0.98 id=36% cov=28%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFKRLADQKKELFEEDLESIVSE-AVTKVPERYSLQSLNTQSGTNQLPTATVELEMDGHVIKETGTGDGPVDAVYRTIAGITQTKSKLLAYVVKAITGGTDAQGEVSVRVEQDGEIVTGNGANTDIIVASAQAYLNALNKLASQLE-------------------
>UniRef50_Q97MD8(153-351:356) Homocitrate syntase, omega subunit nifV (NivO) n=1 Tax=Clostridium acetobutylicum RepID=Q97MD8_CLOAB  E=1e-32 s/c=0.72 id=29% cov=33%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIIRRIKNTFCSLVDFCASNKYFMATAISMEALNDGADFITVAFN--GERYGISSFEEVILALKVMKK---VKVTEKLDLLNDLSKIYEKLFRKAISPMKPIIGEDIFKYESGIHVDGIEKNPLTYEPYEPSIIGADRQMF-IGKHSGRKAVEIKLRELNIETMLCNMDKFLSRIRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0FUY3(1-246:431) Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0FUY3_9FIRM  E=2e-32 s/c=0.58 id=22% cov=44%
MS-NIRLLDCTLRDGGYVNDWKFGHDNLVGIFERLVDANVDIIEIGF-LDDRRPFDIDRSIMPntacaekiwkdvEHKNVMVVGMIDYGTCDISN-IQPCCDSFLDGIRVIFK--------------EHLMKEAMEYCRQIKKLGYKVFAQLVSVTTYTKESMLELIELVNDVKPYAVSMVDTYGLLKPNTLLEYYEILDEYV--YPEVQIGFHAHNNFQLAYANALAFVSKPNKkhdiVVDGTLFGMGKSAGNAPIELLAMSLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1T1D8(11-225:304) Pyruvate carboxyltransferase n=1 Tax=Burkholderia ambifaria MEX-5 RepID=B1T1D8_9BURK  E=2e-32 s/c=0.67 id=27% cov=38%
----VTLLDCTLRDGGYINDHDFSAPQIDAILTRLIASGVDVIEVGYFRRRnlerhaatiaHCPHAFLASLARQAP-VRYGVMVP--PGDVEAAdLDELADLPVSVVRF--------------TCTDRNLDKAAALGERAKRLGLTTCGNITRVSECSPAQLAEVTRTLAAAGFDTLYAADSNGALHPTDVTDIVGEMRRHFTG----QLGFHAHDSLHLAVANALAAMSAGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q12KS9(2-254:539) Pyruvate carboxyltransferase n=2 Tax=Gammaproteobacteria RepID=Q12KS9_SHEDO  E=2e-32 s/c=0.57 id=22% cov=45%
------ILDCTLRDGGYYNNWDFCPEVVSAYLDAMAKSKIDYVELGlrnFPKKGfDGPFayttESFLKGLGLPSGPTYGVMV-----DAKTVLDAPMTIEQAIDKLFVDASKSPIKLVRVAAHFHEVEHSGPIVKALKAKGYIVGYNLMQAGGKPNEVIAAKAKVASQWnSLDSLYFADSLGNMDATEVTRIVKALRTEWSG----DIGIHTHNNMGKALDNTLTAKELGVNWLDVTVTGMGRGAGNAQTESLLAVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0FNJ3(3-248:333) Conserved uncharacterized protein n=2 Tax=Erwinia pyrifoliae RepID=D0FNJ3_ERWPY  E=1e-31 s/c=0.57 id=24% cov=44%
-NSNVILLDCTFRDGGYYTNWNFDEDLVNIYYSAIIETDVDIMEAGYISVDASDCGRFKVenisgfnFLSVIPGKSWAAMidsksILCLENWHDIVIHILKKPARPVIDI------IRVATKFNQ-----LDNIDQLCNIISASGYRVALNLMQIDLACEEEVTAVFEKISSIKsIETVYLADSFGSMPPQRVAELITRLKE----ITSANIGFHAHNNMGMALINSMTAIQAGANWIDTTFAGMGRGAGNAATEEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5RN58(102-349:349) NifV2 n=1 Tax=Clostridium cellulovorans 743B RepID=C5RN58_CLOCL   E=8e-31 s/c=0.55 id=26% cov=34%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYDYIlrEKYIDGIKEVYNVEISFCASNRLNMATAVTLEGLLDGNEMIIGTFN--GEVYGVASIEEVLLALKVIKDYKIIG---DISGIKKLTQNYQELTSENISRIKPVIGEEIFNFESGIHADGIIKSPLTYEPYEPELVGTNRRMI-IGKHSGTKAIEYRLMQLNILSSDVNLKWMLEEVRE-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9RJA2(4-246:313) Pyruvate carboxyltransferase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJA2_FIBSS  E=6e-30 s/c=0.55 id=21% cov=43%
--ETIKVLDCTIRDGGLVNKHDFSLEFVRRLYTLLTAAGVDYMEMGY-KNSPELFDP----KEYGPW-KFCddDLLWKVKDGIDSKMKMAVMADVGRVNMdavkPASESPYQMFRV--ASYVKNIDKGISMVNAFHDMGYETTLNIMAVSRDRGPELDEALHQVnEECKADVLYLVDSFGAFYQEDID---KELARYKGIVKNKKFGFHGHNNQQLAFSNTIQAIINHVDYLDGSVSGMGRGAGNC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B3QVI9(2-244:510) Pyruvate carboxyltransferase n=5 Tax=Bacteroidetes/Chlorobi group RepID=B3QVI9_CHLT3  E=7e-30 s/c=0.55 id=23% cov=41%
------VLDCTLRDGGYYTNWDFDGELVQKYFSSFEKLPVDYLEIGYRSLPEKEYRgrfyylpnfVIDEITQLSKNKLLAIMLnekSVQPKNLDKILDGLAPV-ISLIRLAV--------------DPKNFDSALLLGEAIRKRGFDVAFNLMYMSKYanDESFLGKL--SSLNGLASYVNMVDSYGGMVPEQVKILIHNVKSYCRE----AIGFHPHNNMELAFANSLAAIDAGCEIVDTTVMGMGRGAGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0LRX4(4-266:311) Pyruvate carboxyltransferase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LRX4_HALO1  E=2e-29 s/c=0.51 id=19% cov=43%
------LLDVTLREVGEASGYAFDIDDAIGLAQQLSAAKLDGVEIGYvrprawsgpPSAQTCSPTYIERLRQALGSARLAVFVH-LHEIPAGGLVALRPLGVDLIRLAVAA-----------DRPEIL---RERAAELRALGIEFSVNAIRMTEHEPARIVELGRIAEDVGASMFYVADSNGSLYPLLFAKLAAQLRTEL----SIPLGAHLHDNLSLAMANAIVALSHGFEWIDGSLAGAGKGGGNLATERLALHLQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A0RQG5(1-276:613) Biotin/lipoyl attachment n=15 Tax=Bacteria RepID=A0RQG5_CAMFF   E=1e-24 s/c=0.42 id=21% cov=40%
MAKKfIDVMDTTFRDGFQSVfGARVLMDDFLPAVSAAKEAGINHFEFGGGARFQSlyfylnedaflMMDKFRQAAGN--DANLQTLSRGVntvtldtgsRELVDLHAKLFAKHNTNTIRNFDALNDV---KNLKYSGERIVH---------HGLKHEVVVTMMDlppncEGAHDAAFYEKCLRDILnsDIKFHSVCFKDASGTSSPEKVYQTIKMARRLL--GDSVHLRLHTHETAGVSVACYLAALEAGADGI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5NZV9(1-279:494) Putative uncharacterized protein xccA n=1 Tax=Aromatoleum aromaticum EbN1 RepID=Q5NZV9_AZOSE  E=2e-24 s/c=0.42 id=21% cov=37%
MTD-VHLVDVSLRDGNQSLwgAVGVKTRTIERVCPAIDRVGYRALEllsstqvaVAVRFHREDPWARIDAASRAAPRTplgflttgkRFISFSRTPANLFQLAFDLLRRHGVTRMWIIDPMHD--------------MASARETARMARRAGFDevVAGICYTISpvHTDDYFADRVAELDDCEAIDSVYLKDPAGLLTPARLESLVPHMRQRLKRLR--IDELHTHCNTGLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3IQK7(2-270:296) Homolog to 2-isopropylmalate synthase, homocitrate synthase n=1 Tax=Natronomonas pharaonis DSM 2160 RepID=Q3IQK7_NATPD  E=1e-23 s/c=0.42 id=25% cov=41%
-----------------------TADQRVEAGRALDRLGVPLVRAGRPAHDETDAEVVRRLAD-----TLSADTVAVAPPDYEAVEDALETEADIIDVFVPVAGPRLEAAFGGSSEAALDAAEDAVLRAREGGATAHLTLIDAFRAEIPAIAGVFGRFD----CHIVLDDASGGRTPPFVAGFLRTLADASADLTRA--GVRFRDDVGCGTANAIVAAETGIDRVDASVAGVGARAGLAATEELVVA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6L5K8(1-289:591) Pyruvate carboxylase subunit B n=28 Tax=Bacteroidales RepID=A6L5K8_BACV8  E=2e-23 s/c=0.39 id=20% cov=40%
MKKEIK-FSLVYRDMWQSSGKYQPRADQLAkIAPLIVEMGcFARVE-TNGGAFEQvnllygenPNKAVRTFTKPLREAGIQthMLDRGLnalrmypvPADVRRLMYRVKHAqGVDITRIFCGLNEVRN--------------IIPSIKYAKEAGMIPQATL-CITYSPvhtVDYYSYIADQLIEAGAPEICLKDMAGIGRPEMLGQLVRNIKDKHPE---VIVQYHGHSGPGLSMASILEVCENGADIIDVAM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7SN52(31-388:599) Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SN52_NEMVE   E=2e-13 s/c=0.22 id=17% cov=54%
----IFVLDNTLREttvG-QLRGHTI--DNKWAIYDQVKKIGFEHMIVASFNHMTRLGDtFIKQLHERGEDMTLKyAFTEFLEKiDENRVpIPDLIPVGMRkmkELGIGNAIIEIDLVYNgidykkftINKICDLLLERFRWIRANLNSKDPKIFVNLRDFFDAinkRPRRILKVVNYLSTLPPEdrpfGIVYEES-GKNFPETVGVWTRVIRDEMdrCGFQDGHLLVHVHEQWGMQDVTQLRCLANGANGI---WAGLskeGASMGHACSSVTLMNL-VRMGNKKVLKKFNCEELRNAAIAVTRIvTGRDPDPLQPIYGSRA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1VD30(540-821:1234) Carbamoyl-phosphate synthase L chain, ATP-binding n=9 Tax=Proteobacteria RepID=A1VD30_DESVV  E=2e-13 s/c=0.28 id=21% cov=40%
---HVHFTDTTARDITQSNsGNRFRLAEDALMGPYLDNCNFFSLEngggahfhvammanMTYPFSEAAEWNKFapKTLKQiLIRSTNVLGYKPQPRNLMRITGEMICEH-YQVIRCFDFLN--HV---------ENMRPFAEVALNRNDVVFEPALSLSWARGFDVAHYVGVTEAILRMVGDvagfgpeqasrsiILGLKDMAGVCPPRFMTELVSTLRKRWP---SLVLHCHRHYTDGLFVPAVGAAAKAGAHIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q30ZL8(541-986:1238) Pyruvate carboxylase, putative n=8 Tax=Desulfovibrionales RepID=Q30ZL8_DESDG  E=3e-13 s/c=0.18 id=19% cov=40%
----VHFTDTTARDITQSNsGNRFRLAEDALIGPYLDNCNFFSLEngggahfhvamlanMTYPFTEAAHWNQFapKTAKQiLIRSTNILGYKPQPRNLMRLTGEMICDH-YQIIRCFDFLN--HV---------DNMRPFAEVALNRSGVVFEPAISLSWARGFDVPHYLQVTEAILRMVADvagvssakassmiILGLKDMAGVCPPRFMTELVTALRKAWPQL---VLHYHRHFTDGLFVPAVGAAAKAGAHIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q72JC9(5-509:520) 2-isopropylmalate synthase n=4 Tax=Thermaceae RepID=Q72JC9_THET2   E=1e-149 s/c=1.05 id=45% cov=97%
--RHIRIFDTTLRDGEQSPGVALSLDQKLEIAQALAQLNVDIIEAGFPVSGPMEFEAVRRIATEVKGPIIAALARTHTLDIDQAAKALEKAEKPRIHVFTSASKVHLQYMLRKTEEEVLEMADRMVRYARRYVDDVEFSAQDVMRADWEFVKRLYEVAIEAGATTINIPDTTGYGTPQEYGALIRRIRDEVVRGRDVIISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYkDLSEEEVKKLFARFKEIAEKKGPLSAEELQALVESEREPT-SHFFQLEHVQFFSGSGLLPTATVKVKTPDGERVATHTGDGPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVSPDIIEASALAFLDAAGKLASGRATRH----------------
>UniRef50_B8J824(6-504:523) 2-isopropylmalate synthase n=7 Tax=Bacteria RepID=B8J824_ANAD2   E=1e-143 s/c=1.03 id=48% cov=95%
--QRVTIFDTTLRDGEQSPGASMNLGQKLQVARALRDLGVDVIEAGFAAASPGDLEAIQAVGRQVEGPIVASLSRCNKGDIEASWKALADAPRRRCHVFLATSPIHRDFKLKLAKDEIIKRSVDGVKLAREKFDDVEFSAEDSARTELEFLAEVVERVIEAGVGTVNIPDTVGYALPSTYAETIRYLRKHVRGIEKAVISVHCHNDLGMAVANSLAGVLEGARQVECTINGIGERAGNASLEEIVMAFKTRHDVLGVTTGVQTERLFPTSRLVSQVTGLHVQRNKAIVGQNAFAHEAGIHQHGMLTNRETYEIMRPEEVGFARSQLVLGKHSGRHALKDRLLALGYQLDEAQIDKVFADFKVLADKKKDIYDADIEALVVHGQiLGKGSVAWELEALSTTSGTGTLPCASVALRsAAGERIQEAAAGDGPVDAVYRAIEKVTGISLKLRDYQIASVSRGEDAQGEVSIEVEHPTGVYRGRALSTDIIEGSARAFLDVVNRI------------------------
>UniRef50_B3DX88(5-505:506) 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=LEU1_METI4   E=1e-142 s/c=1.01 id=48% cov=95%
-ANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQGDFESVSEIAAQVKGPKICGLARCLPKDIEaAAEALKAAADAARIHVFLATSQIHRRFKLAKDEEEIVRIAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVNIPDTVGYAVPEEFASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEGTINGIGERAGNAALEEIIMALHTRPDAFGkIETGIQLKEILRTSRLVSRMSGLAVQRNKAVVGENAFAHAAGIHQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLKILGFELEKEEIDNIFSQFKQIGDKKKFIYDDDLVSLV-EGQISRIKETYELEYVAVTVCSGGIPMATIKLRHGEEVLVDASTGDGAVDAAMKAVDRITGQHGHLVEYEVKSVTEGKDAIGEVTVKVNFDSKKlVTAKAASTDVIEASIKAYLNAVNK-------------------------
>UniRef50_C5SF21(9-525:527) Pyruvate carboxyltransferase n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SF21_9CAUL  E=1e-125 s/c=0.87 id=41% cov=94%
-PNRVIVFDTTLRDGEQAPGFSLGVKDKLMLAHTLKDLGVDVIEAGFAASSPGDEEAIRTIAREVVGPTFCSLSRALESDIDAAARALLPAKRKRCHIFLATSPIHRAAKLKKTREQVVEIAHKAVSYASTIFDEVEFSPEDAIRTEQDFLHEVCIAAAEAGARTLNIPDTVGYTTPKEIYQIFSDLKAALKDHPQVILSAHNHDDLGLGVANTLAALEAGARQIEVTINGIGERAGNAALEEVVMALRTRPELFKLHTGINTPLLSKASHLLSRATGTIVMRNKAVVGRNAFAHESGIHQHGMLTDARTYEIMRPEDVGAEKSNLVLGKHSGRHAIAKQAAALGFDLDELSLGDLFAAFKRRADEIGEIDEFELMSLLTRDNADKDDARLFKVSSEV---TKDFVTITLDLfRDNGEPLKVTATGLNAFEAGFRALVDAYQIEARVNDCEIIQSGFTFDGGAFAEISLQIKGEAYRGRGRGPDPVWAGLRAMCDA----------------------------
>UniRef50_Q3M862(6-559:577) 2-isopropylmalate synthase n=4 Tax=Bacteria RepID=Q3M862_ANAVT   E=1e-117 s/c=0.76 id=27% cov=94%
-SPHIWLYDTTLRDGTQREGLSISTEDKLRIAHRLDQLGIPFIEGGWPGANPKDVQFFWQLQEDPLKlSQIVAFCSTRRPHTHAAdepmLQDILAAGSSWVTIFGKSWDLHVTTGLKTTLEENLAMIRDTIEFFRSQGRRVIYDAEhwfDGYKHNRDYALQTLKAAMAAGAEWLVLCDTNGGTLPHEVSQIVQDVVKVTRDWGRInskldqsgqvvseevekstnslpntqypipnlpfpipQIGIHTHNDSDMAVANALAAVMAGATMVQGTINGYGERCGNANLCSLIPNLQLKLGYSCI-TEHQLGQLAEASRFVSEVVNLAPDEHAPFVGRSAFAHKGGIHVSAVERNPLTYEHIQPEQVG-NRRRIVISEQSGISNVLAKARTFGIELDKQtpEAKQILQRLKELeSEGYQFEAAEASFALLMYEALGGRQQFFEVKGFQVHCDlvegkEMTNALATVKVAVNGKNILEAAEGNGPVAALDAALRKALvnfypqLATFELTDYKVRILDGhtGTSAKTRALVESGNGYQRWTTVGVSPNILAASYQAVVEGL---------------------------
>UniRef50_B9KY22(30-540:562) 2-isopropylmalate synthase/homocitrate synthase family protein n=4 Tax=Bacteria RepID=B9KY22_THERP  E=1e-116 s/c=0.83 id=29% cov=93%
--RRVVIYDTTLRDGTQGSGVSLTTEDKLKIARALDELGVAYIEGGWPGSNPKDMAFFERARhQQWRHARITAFGSTRRAGGtveeDVNLRLLLEAETPAVTIVGKASPFQVRVILGTTLDENLRMVAESVAFLKAAGREVIFDAEhffDGYAEDPDYALAVLRAACDAGADAVVLCDTNGGTL---TDPLVRAVRHALSSV-SCTVGIHTHNDCELAVANTIAAVLAGAMHVQGTMNGLGERIGNANLCSIIPILEYKLGYRCLPPG-NLRKLTETSRYVAEVANLAHDPRLPFVGAFAFTHKAGLHVNAIAKHPSAYEHIPPEVVG-NTRHVLVSELSGRSNIVVKARSFGIELgdKPEVVRRVLEQIKEL-EFHGYWFEDADASLELLIRRNlpDYRPPFEVLDYTVLTeyrnGRGMLAEAMVKLRIGQHVFHTAAEGNGPVNALDRATRKALQefypeiAAVDLEDYKVRVLDdhHGTGAKVRVWIRSGDAHGSWNTVGSSENIIEASWLALADSL---------------------------
>UniRef50_A8AB61(16-392:399) 2-isopropylmalate synthase n=25 Tax=Archaea RepID=LEU1_IGNH4   E=1e-114 s/c=1.10 id=43% cov=71%
LPKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQGEFEAVKAIAREGLGPEIVALARANKRDIDKALD----ADVDAIHVFIAASDIHLKYKLRMTREEALRRAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDTVGVMTPTRMKYLIKFI---LPAAKGRIVSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIGERAGNAALEEVVAALEF---LLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHESGIHVHGVINNPFTYEPIQPEMVG-QRRRIVLGKHSGRHGVEYALKTLGYPTDPDVVLRVLDEVKRLGDMGIRVTEDKLREIV------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q97MC5(26-554:558) 2-isopropylmalate synthase n=50 Tax=Bacteria RepID=LEU1_CLOAB   E=1e-113 s/c=0.78 id=24% cov=94%
-----IWCSVDLRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLIEDkliPEDVTIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVKSLAIKGAQMVKKYSEYTeyseskfvfEYSPESFTGTELDYALEVCEAVLNVWKPskenkaIINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADRVEGTLFGNGERTGNLD----IMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHERHPYAGKLVFTAFSGSHQDAIRKGLKslkegknkhwevPYLAVDPHDLGREYEEiIRINSQSGKGGTAYIMEsDFGFILPKAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLENRSPYYLKNYKIHSIQNIEEEKnTVDIEavisVNGKDTSIEGVGNGPVDAFFNAMNNKKYNGCKFISYDEHALNIGSHSKAVAYVQIESQDKKYFGVGISDNIDTASINAIVSALNR-------------------------
>UniRef50_O86511(12-520:534) Uncharacterized AIPM/Hcit synthase family transferase SCO5529 n=62 Tax=Bacteria RepID=LY41_STRCO  E=1e-107 s/c=0.77 id=27% cov=93%
------VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEIdfKHAQLVAFGSTRRAGANAAedhqVKALLDSGAQVITLVAKSHDRHVELALRTTLDENLAMVADTVSHLKAQGRRVFVDCEhffDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGMLPAQIQAVVATVLA----DTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANLFPVVAALELKYG-KQVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVG-NTMRMLVSDMAGRASIELKGKELGIDLggDRELVGRVVERVKerELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITEDRPdgshANEATVKLWAKGERIVATAEGNGPVNALDRSLRVALEkiypelAKLDLVDYKVRILEGvhGTQSTTRVLISTSDGTGEWATVGVAENVIAASWQALEDA----------------------------
>UniRef50_B0CSN8(28-594:603) Predicted protein (Fragment) n=11 Tax=cellular organisms RepID=B0CSN8_LACBS  E=1e-105 s/c=0.68 id=25% cov=93%
-----IWLSTDLRDGNQALANPMTVEQKTTFFRQLVKCGVKQIEVAYPAASETDFQFVRGLIENnevPDDVWIQVLTPAREDLIRRTIDSVAGAKHAILHMYNATSPTFREVVFRSSKEQTIKLAVEHTKIVRQLTEECtakygtvfkyEYSPETFTQTEPEYALEVCEAVKAAWGKagtgddriIFNLPSTVEIAPPNHYADQIENFCRNISEREKIIISLHPHNDRGTAIASAELGMLAGGDRIEGCFFGNGERTGNVDL----VNLALNFYSQGINPGLDFSDIQSVIDVVTQCNDLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEvqkirhaqaaaqgepqywniPYLPIDPADLGQDyEAVIRVNSQSGKGGIAFLIKQhLHLDLPRKMQVLFYQVVQAIADKEAREMTVDDITTAFRRTYKfggsKYAGRLVLRNFRISTERGDDPaefsgddapderrRFDGTLSVDGVYRVIRGDGNGPLSALLDALRTHLDIDYTIRDYIEHslsvgfngqsgqadiAIGEGTEVVAASYVELlyeveGSKKRSAWGVATDTDITASGIKAVLNAV---------------------------
>UniRef50_Q1QBL0(49-584:594) 2-isopropylmalate synthase n=5 Tax=Bacteria RepID=Q1QBL0_PSYCK   E=1e-99 s/c=0.68 id=24% cov=93%
-----IWASVDLRDGNQALIDPMTIEQKMRFFETLIDVGFKEIEIGFPSAAQVEFDFARKLIEEnhvPDDVTLQVLVQAREHLIARTFESLKGAKRAIVHVYNSTCRIQREKVYAKDKAEIKEIAVTGAKLLVEYAAKypetewvFQYSPESFSQTETEYAVEVCDAVCDVWRPEngqeviLNLPATVEASMPNVFADQVEYFCRNLAKREHVTISLHTHNDRGCAVAAAELGVLAGADRIEGTLLGNGERTGNMDIMVMAMNLFSQ----GIDPELDFSNMSEIVQVVSECNNLPLHPRHPYVGELVFTAFSGSHQDAIKKCLDYnekhvektenvwdvaYLPIDPAHIGRSYQDVVrINSQSGKGGVAYILQRnYGFNLPRWMQIDFSGVVQKQAETTARELQNDEILQTFEDTYLQQGSFELLDYTVNNKGGEVYFNGQVQM--NGDTITIDGDGNGPLSSFIDGLAQHTGKSIHVINYAEHAInpqhnsGDGinddnnrdnkTNANAAAYIQLNVDGEVYSGIGTCSSTVSAMLKGALSA----------------------------
>UniRef50_C1ZKW9(26-390:418) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZKW9_PLALI  E=8e-98 s/c=0.99 id=41% cov=69%
-SGRIMLSDTTLRDGEQMPGATLEPEEKREIALALEAAGIHSLDAGFPASSQQDFDAIRLMAQVIKRPVMTALCRTVEGDVDAADEALAGLAphKRGVSLFIGTSPLHREYKLRKSRTEVLSIIDRSVRYASKKFDIVAFSPEDASRTEADFLVECYETAIQAGATTIGYPDTVGVLTPERAYVAIRHVMEHVPSIRKVLVAVHMHNDLGLAVANSLAGLTAGAHIVQCTVNGIGERAGNAALEEVAMALYVNQEQYGRAVKLNYESLFPLCQLVAKKTGVPMALNKPVAGRTIFATEAGIHQDGLLKHPDTYLPYRPEVVGGPAIELVLGRHSGKGAVAHHLQNLGYQATDAHVMFILNQIK------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1AUX2(44-560:570) 2-isopropylmalate synthase n=8 Tax=Bacteria RepID=C1AUX2_RHOOB   E=2e-94 s/c=0.68 id=23% cov=91%
---------VDLRDGNQALAEPMDPERKRRFFELLISIGYKEIEVGYPSASQTDFDFVRDLVRLdlvPDDVTIVVFTAARDDLIARTYESVEGLPNVVVHMYTATAPTWRSVVLGKDRKAlhrlIFDAAQEVARGAGDRpGLRFEFSPEVFNLTEPDFALEVCNsltRLWDASPDRpviHNLPATVEVSTPNVYADQIEYMHRHLEDRESVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDLVTLALNLHAQ----GVDPMIDLSDIDAVRRTVEYCNRIPVHERHPYGGDLVYTAFSGTHQDAIKKGFAehrasaeaagldpgsapwavPYLPIDPADVGRDYqAVIRINSQSGKGGIAHLLQsEYGITLPRRLQIDFAAKVQEAADSSGLEITAEELWTLF---CAEYGYRGGLGRWSVEHGPDGDRLFVV-FDVDGAEASGEAVAAGPVEAMTRVLTS-KGVDVDVLSLTQHSQRSGSDSAAITLAECSVGERTVWGMGSHQSVTASAIRAV-------------------------------
>UniRef50_Q6KZ01(2-372:375) 2-isopropylmalate synthase n=1 Tax=Picrophilus torridus RepID=Q6KZ01_PICTO  E=7e-89 s/c=0.89 id=33% cov=69%
------LLDSTLREGEQTPGVSFSMDARVEIARALSDAGVSMIEAGHPAVSETVLKSIKSIMELkssgIIRSTIVAHSRAVRSDIDVA----ASLNIDMIAIFYGISDLHLKYKTLKTREDAIRIIVDSIDYARSYGLNVRFTAEDATRTDYNYLLDVARAARDAGAKRISIADTVGILNPDTSYKLFKMI---IKDVKNVEFDIHAHNDLGMAVANSIAAYRAGATIIHSTVNGLGERSGITPTQIIGPALKYHYN----EAVIDLKRLYSLSNLVEKYSGVMVPYNYPVTGKNAFTHKSGVHIAGIINKPETYEFMDPCLFG-NKRYYTISSYSGRHAVITRLQELGISLNDEHLKILMKMIKN---KNRELNDDELYAMA------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4S9H2(13-385:390) Pyruvate carboxyltransferase n=13 Tax=Bacteria RepID=B4S9H2_PROA2   E=6e-87 s/c=0.87 id=32% cov=69%
--RPVWIIDTTLRDGEQAPGVAFTPEEKKTIAGKLAECGVNELEIGYPAISSEEQAVITEIARMQLPLRLTSWARAKWEDIDAAIR----CKTQGVHISFPLSELYLQL-MDKPYEWVEEQLHLLVPKAKKYFDFVSVGGQDATRTGPDILERFIREAVECGADRIRIADTVGIATPLHLMQLISRIKKAVP----ATLEFHAHNDLGMATANAFSAMEAGCDAVSVSVTGLGERAGNAALEELAIALKLSG---RYHSSIKTERLQELCGIVAKASNRNIEDQKPVIGASVFRHESGIHCNALLKNPLSYQPFLPGEIGRDNYELVIGKHSGSAAIQHVLAGNGIAIDRKEASRLLAPVRMTADRNKRGISADE----------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0TW82(4-519:526) 2-isopropylmalate synthase n=17 Tax=Francisella RepID=B0TW82_FRAP2   E=1e-86 s/c=0.62 id=27% cov=94%
--KKIYIFDTTLRDGQQSPGAGMSFEDNIAYADLANKLNIDVLEAGFPSASNTDFEIVntisKRMAEKNSNMIIAGLCQLRKNQVEITMDALRPSlaiGKARVHMYLPVDPNLAQASLGSknDNEQNIKNVYELIKLASDQGFEVEFSAEGYSRlgDTFDYVTDVFRAAVSAGVTVINCPDTIGGACERENDNYFvknmtkhaEIIKKEFPD-KNIIWSAHCHNDLGLALENSMNAVFDGpATQVEGCINGVGERAGNASLEQCVMfiNLFGKQKDCHFYNDINIANFKTISDFIGKRM-LSRQPHHPITGLNSARHTSGGHTNAILNNPLAYQPFHPESVG-NEISFIFGPLSGGNHAKKIIEENGYICDDKEKAAIAQQIKDIYHERRKGITDEE--LIQAYKQIKSPIHVSAIDYGKSNGETYVELKGRFFGNTDYRITDRGE-NSALSALLKGIQEYIP-DVNISDYFSRSLkDAGINSKSETTIIIKTGENSpvVEGIAVDQDIEISSLKALITATNKLY-----------------------
>UniRef50_B5JMT2(7-372:372) HMGL-like domain protein n=1 Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMT2_9BACT  E=3e-79 s/c=0.81 id=29% cov=67%
-----YLIDTTLRDGEQAAGVAFSLSEKKAIATLLSQTGIPEIEVGIPAMGECERQHIRAISQLDLDCRILTWGRAVRED----LRAASKSGADGFHFSLPASPLHLR-IWKKNERWVLRTMSELAKEAADTFEYFSVGAQDASRADRDFLKLFIDAAQVLGASRVRIADTTGRLNPIDTLDLFCDITKN----ASIDLEFHAHNDLGMAVANTVSAFIGGATCASVTVNGLGERAGNAALEEVSMALK---HSTDIDIPMDASHYYKLSDYVANASQRRLAWNKPVTGPGAHSHESGIHCKGLLTDSRSYETVSPEEIGQSRPEFAIGRHSGSAAVIAAAQKLGHTLSAKKATALLPLIRTAAEQRGR----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6BX35(2-346:368) Pyruvate carboxyltransferase n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BX35_DESAD  E=5e-73 s/c=0.81 id=31% cov=65%
--------DTTLREGAQLFGAYFNLETRKRIASSLISMGVDEIEMGW--VGQDDLALFAGYARtLGGDTALSVWSPCREKDIEVAAEL----GLKRINIGVPVSDLHIEKRLDSDRQAILRKLAAAVRTAKDCGFEyVSVGLEDISRADGDFALSMALHAEICGASRVRLADSLGQLTPLAMEKLVRKFREKLH----IDIAVHCHDDFGMATANSFTALEAGADYADCSVIGIGERSGIAATEELVARLALREGN----TRYSTTVLKDACMVVGAAAKVAIPRTKAVVGTDIFACESGLHTHALSKSPELFEPYDPDSVG-TVRKLAVGGKSGRAAVRNALDEYGIDCGTDSLSTLTEAVRQL----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9YLN5(2-377:394) 2-isopropylmalate synthase n=2 Tax=Nostocaceae RepID=B9YLN5_ANAAZ   E=6e-72 s/c=0.73 id=29% cov=70%
----IQILDSTLREGEQTPGVYFSPKTKLVIAQFLDRIGIDIIEVGNPAVDTEIALAINQIANAGLKAKIGAHSLCKIDSVQKALD----CDVDFLGIFFSVSPQRLYRDYNICLERAIDKIVEVISYARTQKSDllIRYTPEDTVRSPIENVIAAAKAAVQAGANIISIADTTGYTNPFHpqrsIYFYVKTVKEELGKEGLYPqIEVHCHNDKGLALANVLDAYRAGADIIDVAVMGLGERAGIVDLAELLINLIDMDEEGNFWQLNYLKDLYD---FVSEQSHISIPPHQAVTGKYAFTHYAGVHVKAVAKDERLYQSLNPQILGI-KSSVALGMQSGCAAVELAIKQIGREDLARNKDLITKILKEIKEISKRGTPIDIE---------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6A4Y6(37-418:418) 2-isopropylmalate synthase 1 n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A4Y6_THESM  E=2e-71 s/c=0.71 id=25% cov=67%
-PERVVLHDATIREGQQMPGVAFKRDEIVMIAKALDELGIDRIEL-IPFLSKDDEEAAKELVDMGLNAKLLSFVSWKKEDTDLALKL----DLEGVVLDFVGNPWQGKVFWNLKPEEIIERGVNAALYAKDHGLYVVAMPWDDFKAPLDFVEQNVKALTEAHVDRITICDTYGDALPWAMEYVMKRLKKA---ADKTPLELHIHNDFGLATAGALVAVASGVEGLHVTVNGLGERVGLLSLEEIAVALEF---LLGVKTNINLEKLYEISKIVEEISKVKVAVNKPIVGANQFKYTAGwitwMHRKAREAGKLTgMLPFMPEAVGRQ-LDYVVSKGSGASFVAEKLAELGITVeDPEKMKIIARKVKETA---------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1J0N9(1-227:974) Whole genome shotgun sequence of line PN40024, scaffold_124.assembly12x (Fragment) n=1 Tax=Vitis vinifera RepID=D1J0N9_VITVI  E=4e-53 s/c=0.93 id=52% cov=39%
----------------------MTSKEKLDIARQLAKLGVDIIEAGFPAASKDDLDAVKIIAKEVGNAvdenghvpVICGLARCNRNDISTAWEA---------------------YKLKKSEKEVIEIAREMVKYARSLGcDDVEFSPEDAGRSEREFLYKILGEVIKAGATTLNIPDTVGYTVPNEFGQLIADIKSNTPGIENVIISTHCQNDLGLSTANTIAGACAGARQVEVTINGIGERAGNASLEEVCL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3IV11(4-305:336) Isopropylmalate/homocitrate synthase n=1 Tax=Rhodobacter sphaeroides 2.4.1 RepID=Q3IV11_RHOS4  E=3e-64 s/c=0.82 id=32% cov=57%
--KRTLINDATLREGNQASGVRFSVHDSVAIATALDGIGVDMIEIGHPLAGPYEHQRTEAVAKLGLGAKIIAHARAHRTDI----EAVSRTGATWVGIFLGVNDITTKaRVIGRSTTELIRMVADAVKVAKDCGLNIRYSCEDASRTNTLFLVDVFGAAIDAGADRICYADTLGIAEPAEVARKVTLMKSEFPDAE---VEVHLHDDRGLAMANSLAAIDAGVDSISVSVNALGERCGITDLATLLVNLGFR----GERALPDISELRALSRLVAMSSNTPFDALRPIVGDNAFKHGSKLHQRATQYEPRAY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5AK37(5-312:456) Isopropylmalate/homocitrate/citramalate synthase n=7 Tax=Proteobacteria RepID=C5AK37_BURGB  E=1e-60 s/c=0.77 id=31% cov=58%
------IIDCSLREGCQTIQCNFDIEQSEILARKIAEFGVDMIECGHPKISPYELERVRAVVRVSPLPVL-AHARCRSEDIDAVAE----SGAAWVGMFASFNPVSLATKFgGMGKDQVLALFEASIRYAKSRGLSVRATIEDAGRTEQSDLFRIYQTAVAAGADRICFADSVGALLPSETYDILALLRHEF---RQVQFEYHVHNDRGLALASSLEALRAGVEWISTSCNGIGERAGVTDTFQLAALLESRFG----DASRRLDKARQLSELVRVFSRIDGSPMQPIVGDNVFAHASRLHRIACEKDASAYNIHSPALAG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q72WS3(22-379:384) Homocitrate synthase n=2 Tax=Desulfovibrio vulgaris RepID=Q72WS3_DESVH  E=6e-59 s/c=0.65 id=28% cov=65%
----VMLIDSTLREGAQAYGVYFDAADRESILQGVAASGVTEAEAGW--AGQDDLAAtLRLGARVAPSLRLAVWCRCCTADLDKAAE----AGARRVHIGVPSSDAHMRLRLGMGRDEVLQRVTTVLEHAAHLGfLHVTLGLEDAGRAAPDLLEALARTAARTGAHRLRCSDTVGLLTPDGMVRLVLLARRA----SALPVAVHCHNDLGLATANALAALDAGADGADVSLLGLGERAGITRAEELAAALVVLRGE-----SYRLDMLRGVCRRLAASLEMRLPPHWAVAGENLFAVESGVHLHGVQRDPALFEPFPPALVGA-ERRLGVGGKCGSAGVAAMAHSHGLTLQGDALRRHVRAV-------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5N6T4(42-400:453) 2-isopropylmalate synthase-related protein n=2 Tax=Clostridium kluyveri RepID=A5N6T4_CLOK5  E=3e-58 s/c=0.64 id=26% cov=63%
LPDNIYITDTTFRDGQQSMP-PYTSREIVRIFDYLHELdnnsGiIKQTE--FFLYTKKDRKAAEVCMERGyEFPEVTSWIRADKED----LKLVKDMGIKETGMLMSCSDYHIFKKLKMTRKETMDMYLDLAREALNNGIRPRCHLEDITRADfygfvVPFVNELMKMSKEANIPIkIRACDTLGLGVpyngveiPRSVQGIIHGLR-NICEVPSESIEWHGHNDFYGVVTNSSTAWLYGASSINTSFLGIGERTGNCPLE---AMIFEYAQIKGNTKNMKLHVITELAQYFEKEIKYSVPVRTPFVGTDFNVTRAGIHADGILKDEEIYNIFDTDKILGRPVVVAVSQYSGRAGIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1I1Z4(1-257:301) Pyruvate carboxyltransferase n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1Z4_DESAP  E=1e-57 s/c=0.88 id=34% cov=46%
---QVFLVDTTLRDGEQTPGLVFSTEEKVAVASALDRLGVELIEAGIPAMGVDEQKAVRAVLGAGLRARVLAWNRAHPSDI----EASLACGATCLQISFPVSDIHLQHKLGRTRSWLLARLEEVMALAVAPGREVAVGAEDASRADPAFLRLFAKKAEEAGACRLRYCDTVGVLDPFRSRDAVSDLTHKL----NIPLEFHAHNDFGMATANTLAAVKGGAAYLDVTVNGLGERAGNASLSAVARGLR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P35915(3-286:298) Hydroxymethylglutaryl-CoA lyase n=108 Tax=cellular organisms RepID=HMGCL_CHICK  E=7e-55 s/c=0.76 id=22% cov=49%
-PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATsfvSPRWVPQMADhaEVMQGINKLPGVSYPVLTPNLKG-----FQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLERFSEVMNAARAASIPVRGYVSCVLGCPYEgnisaaKVAEVSKKMYSMGCYEISLGDRIGIGTPGSMKEMLAAVMKEVPVG---ALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGgcpyaqGASGNVATEDLVYMLN----GLGIHTGVDLQKLMDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2VQL9(75-358:422) Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VQL9_NAEGR   E=1e-54 s/c=0.76 id=21% cov=51%
MPSFVKIVEVGPRDGLQNEKKLVPTNVKISLIDKLTEAGLPSVEVTsfvSPKWVPQMGDNFDVFtgIKRREGTAYPVLTPNVKG-----LEQALEAGVKEVAIFLAASDAFSMKNINCTVEESFKRYDQVMELAIKNDLKIRGYvscvagCPYSGYVSPETVAQVSYRLLKMGCYEVSLGDTIGVGTPGSVSMLLHQVCKKIPTGQ---IAVHFHNTYGQALSNILTSLQFGVETVDSSVAGLGgcpyakGASGNISTEDVVYML----HGMGINTGVDLDKLIDAGDYISTYLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1QUV5(1-237:265) Homocitrate synthase 1 n=2 Tax=Clostridium butyricum RepID=B1QUV5_CLOBU  E=5e-54 s/c=0.91 id=30% cov=45%
MKRNVNIVDTTLRDGEQSAGKAFTMEQKLKIAKYLDNNGIYQIECGIPAMGCMEQEIIKAIKANTKNALISTWNRLNIDDIKASMN----CKPHIIHISVPVSDLQIYENLNKDKKWIEENLIKCIYYTKEQGYDVTVGLEDASRADIKYIIELSSLIEKLGVNRIRYSDTVGILSLLKTKNVVNEIRRN----SNLKVEIHAHNDFGMALGISVEAVKNGAEFVDCTLDGIGERTGNCSLQE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q15RQ1(5-304:305) Hydroxymethylglutaryl-CoA lyase n=89 Tax=Bacteria RepID=Q15RQ1_PSEA6  E=2e-52 s/c=0.70 id=24% cov=49%
LPSKVKIVEVGPRDGLQNEKASIDLVTKVTLIEALAKSGLSMIETGsfvSPKWVPQMADSAQvfAAINRQDTVIYSALTPNLTG-----FEAALEAGADEVAIFGSASESFSQKNINCSIAESLARFEPVIAAAKAKNIKVRGYVSCVLGCPYEGeiapanVASVAKTLFEMGCYEISLGDTIGVGTPIATQIMLNAVLDVVP---LCAVAVHFHDTYGQALANILVALQLGINVVDSAVAGLGgcpyakGASGNVATEDVVYML----HGMGIATGIDLSML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9WGE2(2-301:317) Pyruvate carboxyltransferase n=5 Tax=Chloroflexaceae RepID=A9WGE2_CHLAA  E=2e-47 s/c=0.64 id=24% cov=52%
--EAVTIVDVAPRDGLQNEPDVLEPATRVELIERLLAAGVPRIEIGSfvnPRQVPQMAgidQIARMLIERGHNLaarttndlfRFTALVPN-----QRGYELAAAAGLRHVRLVLAASDGLNRANFKRTTAESLIEFSRFALNIRRDGLTfgvaigAAFGCPFDGYVSPERVRAIAEHAVDIGAGEIILADTTGMAVPTQVAALCRTILDRIP---DVTVTLHLHNTRNTGYANAFAAWQVGIRSFDAALGGIGGCPfapravGNIASED----LVHLFNGLGVPTGIDLSALIAASDWLSATLGRPLP---ALVGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0FWC0(28-324:337) Putative hydroxymethylglutaryl-CoA lyase n=1 Tax=Roseovarius sp. HTCC2601 RepID=Q0FWC0_9RHOB  E=1e-45 s/c=0.63 id=22% cov=52%
LPSKVHIVEEGAREGFQSEPAGIPTSEKIRLIEALAETGVPEIDCASfvnPKVVPQMADVaqIAEGIRKREGVTYGCMWLNAKGFLQAAESGLSLPAL----TSGSASDTFLARNNNATPEKQLEGQRKLRALYTEHGlgrgpvyLFTAFGCNYEGDIPVakalERAADLVGVCEEAGqpPSCIYLCDTIGAADPLQVRALVEAVRTRWPDY---PVALHLHDTRGLGIANAMAGLELGVARFDASVGGLGGcpfagnrsAAGNIATEE----LALLCDRMGIETGIDIPALLGVAQIAEEIVNHPLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1Y373(6-281:311) Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y373_9BACT  E=6e-45 s/c=0.67 id=21% cov=46%
------------RDGFQGICDFIPTEKKVEFIGQMLSTGIKEMEITsfvSPKAIPQLSDAAQvlpAVKKEYPDVEFTALVPNVKG-----AENALAAGADVVNVVFSVSESHNMANIRRTVEQSLSGMDDIIALVRgkakiCVSMATSFMCPFEGRIDPRRVAELIGKVRAKGVDCITLAETIGTCTPKDFTETLQVVK---PALEGIPTYLHIHNTYGFADMNVKCALDEGFNRFDSAVGGLGgcpfapGAAGNAATED----LVYLMQSMGVDTGLD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9K380(10-383:420) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Agrobacterium vitis S4 RepID=B9K380_AGRVS  E=1e-44 s/c=0.49 id=23% cov=68%
LSNRVIFHEEVARDGAQG-KTLLNGHQRVQIAKRHSSIFGEfapyhlVFNAGFPSAGKDELEATRQVVDCVDECYVGAAGRATRQDVDLLLQAVHGARHGRIFIAVPASNPMAYSMMHCTAEKAKQAALDMVRYARDKnpALMVDVALADASRSDVGFLAASAAEYAAAGASMVIVCDTVGQFFPSESRWFFDELARR--SDPDLRYVAHMHNDLGFGLVNTLEALSAKIYGLTSSWLSLGERAGMPATEQLLFALGYQSSLLPKKLGVvdeiwrsppDLRQLSPIARYVSQSTRRPLMTTDPIVGTGVNTISTGT----PFTNPALFQPFDPLEILGVEPKVLLSSLASHRIIHAVAARLGWALDQSQASAALEWVKAEA---------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000050F830(4-293:311) pyruvate carboxyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050F830  E=1e-44 s/c=0.63 id=23% cov=52%
LPERARVVEVGLRDGLQAIDTPLSTDRKIAIVSEMIAAGFKEIEVASfahPKVLPQlaDAEAVLAGIPRPPDVRFRALVPNARGALRAA-----KCELDELTFVVPAEDGMALKNQGTTTDGLLDQLDEIREVSGGAGqrlivaVACAFFSPCYGPVSKDARDKVVRKAIEVGADGVYLATTTGEETPL---ELFSGISETKHDFPDLEVGAHLHNRNGFAPANALAALSAGADWLESSVAGLGGDMwfpgdpsvlGNMATEDLIHLL----DGMGISTGIDLNRVRHISEGLIEETKFPVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8PPD2(1-274:624) Oxaloacetate decarboxylase alpha subunit n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PPD2_9SPIO  E=8e-44 s/c=0.66 id=22% cov=39%
MAHKVRISDLVLRDAHQSLhATRMTTADMLPICSKLDSVGYWSLEAWGGatfdacirFLNEDPWERLRSLHKALPNTPIMMLLRGQnllgyrhyaDDVVDAFVKAAADNGVGVFRIFDALNDPRNLK--------------RAADAAKKTGKHVQMAISFATtpYHTIDKYAELAKTYTEFGADSICIKDMAGLLKPFDAFDLVTAIKKK----TSIPINIHTHATTGLSVATLLKAAEAGAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8IFJ3(13-285:313) Pyruvate carboxyltransferase n=3 Tax=Alphaproteobacteria RepID=B8IFJ3_METNO  E=3e-43 s/c=0.66 id=21% cov=48%
------------RDGYQGIGPFIATERKIELLGRLVAAGLRRIEIGSFVsatALPQMRDtpDILAACKQFPDLEPQVLVPSERRGRD-----AVAAGARRLVFVLSVSEAHNRNNVRRAPEESADEYRRLLQAipddvAIRLDLATAFDCPFEGRIPEAKTLALLKRLVALKPDaEICLCDTTGRADPDHVGRLFSEAPSRFPEVK--AWALHAHDTYGLGLANVHAAYREGVRIFDASFAGLGgcpfapGATGNVATEDLVWM----FERMGVATGVDLAALVSVAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0QLF7(25-299:683) Pcb n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QLF7_DESAH   E=3e-43 s/c=0.65 id=21% cov=44%
------IMDLSLRDGHQSLfATRGRTEDMIPVAERMDAVGFWAVEVWggatfdsmHRFLNEDPWERIRTLKRYFKKTPFSMLLRGQnlvgyrnyaDDVAKAFVNRACENGMDVFRTFDALNDYRN-----------FEAVVPVIKSCGKHFqGSICYSLteprMGGTVYTLEYYVNKAKELVDLGADSICIKDMAGLMAPYDAFDLVKALKESV----DIPINLHSHFTSGMAPMTHLKAVEAGVDILDTCLTPYAYRTSHPALEPMVMSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8FC64(11-298:303) Pyruvate carboxyltransferase n=2 Tax=Bacteria RepID=B8FC64_DESAA   E=3e-42 s/c=0.61 id=24% cov=43%
-PSRVVIREVGPRDGFQAEDVIIPTDMKRKVIGDLARAGITHIQAVSfvhPKRVPQmaDAERLMESLEKQPGVVYSGLALNP-----AGVKRAGASRVDAVEVSISASDSHSRKNTGMGRDEAMAQAGDMIALARDANLDViagvqcAFGCAYEGGIPEKRVLKMVEAFLAHSPQALCIADTTGMAGPLEVGGLMSRIASM---AGDLPVFLHLHDTRGLGLVNMTAAIMSGIHHFDASLGGMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7LZC1(1-298:311) Pyruvate carboxyltransferase n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZC1_ACIFD  E=5e-42 s/c=0.59 id=27% cov=41%
------------RDGLQNEATPVVTRDKLELIEACVAAGVDRIEVASfahPSLVPQMADAEAVIEQLSE----AALARAIAlVLNQRGLERALRTRIREINVVVAASEGFARANQRATRTELLATARNVLADAraadlrRSLTISVAFGCPFDGEVDPHEVVRIVETIREAdPACEIALGDTIGAAAPGDVARMLELLADLVAPNE---LRLHFHNTRNAGIANAWEAMRLGVRTFDASMGGIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001BC2CD2(4-280:306) pyruvate carboxyltransferase n=1 Tax=Brevibacterium linens BL2 RepID=UPI0001BC2CD2  E=6e-42 s/c=0.63 id=26% cov=43%
-PTSVTILDTTLRDGLQIEDAIVPTDAKVALGEQLIAAGLKEIEVGSfvnPKKVPQMADTGEVLQRlqshEAEGVDFFTLVFNLKG-----AQRAVDAGAKNIKLVLSASEGHSQANSDAPIAQATQRLLEAATFAKDNGVRfdiataVSFICPFDGITDADHLVEVLRPFVDAGAHGVGVADTIGNANPSLVARNTSAVIEAFPGN---PVNLHLHDTYNFGMANVIAALDLGISNFDAAMGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5BD63(1-300:303) Putative uncharacterized protein n=1 Tax=Edwardsiella ictaluri 93-146 RepID=C5BD63_EDWI9  E=1e-41 s/c=0.58 id=18% cov=50%
MTEqtRVNIVEIGPRDGFQNVRDFIPTALKIEIIEGIISAGVQRMQLTsfvSPAAIAQMRDAeiiSRHCIPRYPDRQFSALVPNFHG-----ARLAQACGYREITPVISLSETHNLKNVNKTHRQSLDEIARIRQSFPEVhivqDIATVFGCPYEGRMATPPLLALITALTAEGIDEFTLCDTIGVAYPEQVLSTLNAVRSAFP---AVKLNIHIHDTRNMGIINSYLAAAWPVDAIQTSLGGLGgcpfapGASGNTATEDLVYLLHAQ----GMATGIDFSRLLATAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1ZXN8(525-826:1165) Pyruvate carboxylase n=5 Tax=Bacteria RepID=B1ZXN8_OPITP   E=2e-41 s/c=0.57 id=19% cov=50%
--KRLLITDTTLRDAHQSLmATRVRTYDMRAVADAlahhapglfsLEMWGGATFDTAMRFLYEDPWDRLRQLRAAVPNICFQMLLRGAnavgytnypDHVVAGFVRHAASAGMDIFRIFDSLNYLPNLRVA----MEAVQDTHAVCEAAICYTGDILDGKRD--KFSLQYYVKLARELERMGAHFLAIKDMAGLCRPYAAYKLVKALREEI----GLPIHFHTHDTSGIAATSVLRASDAGVDVVDLAIASMSGSTSQPNLNSIVAAL----QHTPRDPQLDLERLNAVSDYWEHV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5YV93(5-264:346) 4-hydroxy-2-oxovalerate aldolase 2 n=1 Tax=Nocardia farcinica RepID=HOA2_NOCFA  E=2e-41 s/c=0.67 id=23% cov=42%
-TRTVTLVDTTLRDGMSSVSHRFTPNDVAAIAAGLDRAGVRTIEVAhgiglgassiqYGFAAATDPEYVRAAVDAVDHADIAVLYVPGIATL-AELRAAVEAGIRTVRVAVHCTEA--------------DCAQQPVEWAKDHGLTVMTFLMMSHKLDPEPLAEQAVKLESYGADVVYVVDSAGAMVPRHAGDRVAALRRAI----SAEIGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7MMV3(1-281:634) Acetyl-CoA carboxylase, biotin carboxyl carrier protein n=4 Tax=Coriobacteriaceae RepID=C7MMV3_CRYCD  E=4e-41 s/c=0.61 id=23% cov=39%
---KLQLMDTTIRDGQQSLwATRMPVGDMLPILPAMDKVGYWAIEAWGGatfdtclrFLDENPWERLRQIKAKTPNTRLAMLTRGQnlvgykhysRDIVNRFLKAAQRNGVDVFRVFDALNDIRNV----TDSAEAVKEAGGWFEGAISYTISPVHTL--------DSYLEYAQQLKELGADSIAIKDMAGMLTPYRTERMVRALNDEI----GLPVHVHCHYVGGMAPANILKAAEAGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3JDD8(8-296:312) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Proteobacteria RepID=A3JDD8_9ALTE  E=1e-40 s/c=0.59 id=25% cov=44%
------------RDGFQSIHELLPTAGKIQCVQALIDSGITRIEIGSFvssKAIPQMADIgnIVAAFSDHTGMRFSALVPNLKG-----ADRALASGIKELVFVVSVSETHNQSNVRQSVDSSLDGLKTIADRLRSEKHSVrlrldlatCFDCPYEGEIQWQQVDAVLGKARNIckGIElEVALCDTTGRATPYQVANHFTRLRER-HDSPSLKWAFHGHDTFGMGVANALFAVQHGATTLDASAAGLGgcpfapGATGNTATEDLIYAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P32327(559-834:1180) Pyruvate carboxylase 2 n=326 Tax=cellular organisms RepID=PYC2_YEAST  E=5e-40 s/c=0.61 id=26% cov=41%
-----LLMDTTWRDAHQSlLATRVRTHDLATIAPttahalagafALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVaysslpdnaIDHFVKQAKDNGVDIFRVFDALNDLeQLKVGVN-----AVKKAGGVVEATVCYSGDM---LQPGKKYNLDYYLEVVEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRTRYPDL---PIHVHSHDSAGTAVASMTACALAGADVVDVAIN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2V325(528-802:1146) Pyruvate carboxylase n=9 Tax=Clostridiales RepID=B2V325_CLOBA   E=7e-40 s/c=0.61 id=21% cov=45%
---KLLLTDTTMRDAQQSLmATRVRSKDMKNIAKAtalygndlfsLEMWGGATFDTAYRFLKESPWRRLDSLRKRIPNVMFQMLIRGAngvgyknypDNVIREFIKESANSGIDIFRIFDSLNWL---KGIEVSLEEVLK-ANKVAEVALCYTGDIL--DENRDKYSLKYYVDKAKEIEKMGAHILAIKDMSALLKPYAAKKLITALKNEV----SIPIHLHTHDTTGNGVATVLMAADAGVDIIDTTFNSMSGLTSQPALNSIVAALN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C37344(2-274:465) hypothetical protein RflaF_17007 n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37344  E=2e-39 s/c=0.61 id=20% cov=37%
--KKVQLTETVLRDANQSLmATRLPYADYEGILDDMDKAGYYSIECWGGAtfdsclryLGEDPWERLRNLRKHLPNNRLQMLLRGqnllgykhyHDDVVEKFIELSIKNGIDVIRIFDALNDFRN----------IRTALEATKKYATDK--TIASGCISYTQSPvhtVDKYIEMCKELKTMGFDTICLKDMAGTMSPYEAEHLIKGIKDAIGDMTLI---LHTHCTTGMA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3PWS9(4-289:301) Hydroxymethylglutaryl-CoA lyase n=12 Tax=Mycobacterium RepID=A3PWS9_MYCSJ  E=4e-39 s/c=0.58 id=23% cov=43%
LPAKVDIREVSLRDGLQIE-QPIPLSAKLELLEAVVATGVREVEATafvSPSKVPalADAAALAAELGRFDQVEFSALVASSNG-----AKRAIAAGLRSIEYVVSAADSHSRANVGRSSMESVAAIPDIVAIAHDSGATVEViiatawDCPFDGPTPPQRVVEIVDAAVGFGVDRLAIADTIGTATPRRVSDLVTQVR---PRIGDLPLGAHFHNTRGAGLASAYAAVQAGITRLDSSVGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8LCZ8(638-943:1291) Predicted protein n=3 Tax=Eukaryota RepID=B8LCZ8_THAPS   E=2e-38 s/c=0.53 id=22% cov=42%
--QNVLVTDTTWRDAHQSlLATRMRTADLLKAAEAtntafngtsdvfsLEMWGGATFDVSMNFLRECPWKRLEELREAAPDMLFQMLLRGAnavgytvypDNVVYEFCKQAYKSGNDIFRVFDSLNYVDNMELGIKAAAAS----GGFVEAAICYTGDVT-SSDPSNKYNLKYYLDFATQLVDLGAHALAIKDMAGLLTPRAATLLVSELRSAFP---DVPIHLHTHDTAGMGVAAMFAGAEAGADIVDGAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6KI73(54-297:451) Hydroxymethylglutaryl-CoA lyase, putative n=3 Tax=Toxoplasma gondii RepID=B6KI73_TOXGO  E=9e-38 s/c=0.66 id=23% cov=43%
---KVRIVEVSPRDGLQNEEKVLSLDDKITFINMLETAGLSTIEIASfvnPVKVPQMADAAaltRQFCSRSKNigglsPTFQVLVANMRG-----FEEAAEAGAQEISLFTATTDAFCRANINTTVSESLKKFSVIAREAADRGIKTRGYVSCIFECPYQgkvaptTVVQVARHLLDMGCYEVSLGDTLGVGTAGPTLNLMEELHRN--NFPMETVAMHLHDTYGQALANILVSiVHGGVRVVDTAVAGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5THN3(2-196:203) LeuA allosteric (Dimerization) domain protein n=1 Tax=Zymomonas mobilis subsp. mobilis ATCC 10988 RepID=C5THN3_ZYMMO  E=5e-36 s/c=0.79 id=25% cov=37%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYLPIDPADLGRSyEAVIRVNSQSGKGGVAWVIEQdQGLKMPRRMQVDFSRKVQELADSSSKELDSSDIWNAFVDYYHlDNSGHFQLVDFQVKQGDNGYAIIG-KIKAGDNIHEVEGHGNGLISSIIDALSSITNIRLEVVDYQEHAISHGNTAQAAAYIECSLpQGGTVFGVGVDDDIATASVRAVLSAVNRAYA----------------------
>UniRef50_UPI0001B44BFA(8-246:483) 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Mycobacterium tuberculosis KZN 4207 RepID=UPI0001B44BFA  E=8e-36 s/c=0.64 id=24% cov=43%
-----IVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIgaaaaqgpaaHTDEEYFRAARSVVRNARLGAVIVPALARIE-TVDLAGDY-LDFLRICVIATE--------------FELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEALR----GASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8KZT0(6-245:359) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Rhodococcus jostii RHA1 RepID=Q8KZT0_RHOSR  E=4e-35 s/c=0.63 id=27% cov=43%
LRDDVRIVDTTLRDGSHAQSHQFTESQVRDTVRALDGAGVEVIEVThgdglggstfnYGFSRISDLELVQVAADTAEQAKIAVLLVPGIGTADD-LRKAADRGAEVVRI-----------ATHCTEADV---SLQHFEIARDLGMQTCGFLMMAHRTTPEELARQARLMVDAGCQVPYVTDSAGALLMHEAKDRFDALITEV--GDDAWVGYHGHQNMSLGVANSVIAYEAGVRYIDGSLCALGAGSGNSPTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8LAA1(31-285:377) 4-hydroxy-2-oxovalerate aldolase 1 n=265 Tax=Bacteria RepID=HOA1_FRASN  E=3e-34 s/c=0.58 id=26% cov=43%
--------DVTLRDGMHAVRHRYSVETARTIATALDASGVRAIEVAHGdglaGSSinygigaHTDWEWIEAVTASVTNAIPTSLLLPGIGTV-RDLRQAHALGIRSVRVATHCTEA--------------DISAQHISAARDLGMDVAGFLMMSHMAAPAELARQARLMESYGAHCVYVTDSGGRLTMDDVRDRFRAYSDVLDPATET--GIHAHHNLGLGVANTVVAVENGATRVDASLAGQGAGAGNCPLEAFIAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9L0X3(1-287:496) Pyruvate carboxylase subunit B n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0X3_THERP  E=3e-34 s/c=0.52 id=19% cov=41%
MAPRIQLIDVTLRDGNQSLwsAIGVDTRTVAEVAPWIDRAGFASIDFttsTHMAISvryhrEDPFEKIRLARLLMPNTplifmttgmRFITWEPAPRAIMRLALRVVVRHGIRRVQIVEPMN--------------NMSALLEAARIAREEGAEQVVAGLVYSISPVhtdEFYLRCAEDLARERqlLDRVYIKDPSGLLTPERVQTIVPALRRAL--GPDVPLEMHSHCTMGMAPLCYLRAVELGVQTVHTAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0QM22(1-350:369) LeuA1 n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QM22_DESAH  E=4e-34 s/c=0.42 id=24% cov=53%
----------------QHRGMVFSSNQAMTVLNFQERLGVDICQAGYPPAHESEQAKLKHLsasaVEKGYSIRVAAMGRACLEDV----QTLSETGTLDFHLHAHVS----KEKWNSPMDQAFPDLGTTVEtiRANCPGSQISLAFLDIGRTDPEFLSRAALYLIKELAlDILSLPDTSGIMGPNQVHDAIAPI-ARLSRNSSTRLAVHCHNDLGMASANTVMGVVAGATVVEASVFGLGERNGLADLYTTARVLKDQGYALDLRLE-DVDTFREYYRYIDGVCRQQtgeplLTYNTPFFGDGVKTHVAGTH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9SIZ2(461-751:1073) Pyruvate carboxylase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SIZ2_VERA1  E=1e-33 s/c=0.51 id=22% cov=41%
-----LLMDTTWRDAHQSlLATRVRTVDLLNIAHEtshalsnlysLECWGGATFDVAMRFLYEDPWDRLRRMRKLVPNIPFQMLLRGANGVaysslpdnaIEQFVDQAKKCGVDIFRVFDALNDVSQIEVGVK----AVHKAGGVVEAVACYsGDMLMLNAHLATkkhlsknpnkKYNLQYYLDLVDKLVALDIHVLGIKDMAGVLKPHAATLLIGAIREKYPDL---PIHVHTHDSAGTGVASMVACAKAGADAV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4XTF5(2-255:345) Putative 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XTF5_DESMR  E=4e-33 s/c=0.57 id=20% cov=45%
--KNVTLLECTLRDGAYKVDFMIDQETCCAFAEKLVRIGFQDIEVGHGlglgayrqySAGFTDEALYKRLAPLAARSRLYSFFIPSVGKPDDF-RMARDYGLYGLRV-------------GAEPVYVLDSI-PTLEAAKSLGYFVALNVMKSYTVTPDGFAKLVETVKDF-VDVIYLVDSAGHMLPEELRAYVRAIQDRV---GMIALGYHGHNNLGLAVASALELLDEGVQYIDTTLTGIGRSGGNIPTETMLAVLAKKYGV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q08T06(39-215:215) Hydroxymethylglutaryl-CoA lyase (Fragment) n=1 Tax=Stigmatella aurantiaca DW4/3-1 RepID=Q08T06_STIAU  E=1e-32 s/c=0.81 id=22% cov=24%
LPQRVDVYEVGPRDGLQNELRTLPTKDKARLVEALVAAGEKRIEVTsfvSPKWIPQlaDAEELLRLVGRKPGVVFSALVPNLKG-----LQRAREAGLQEAAVFISASEAHSKKNINKSIAEALEASREVATAAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A2U042(1-264:516) HMGL-like protein n=1 Tax=Polaribacter sp. MED152 RepID=A2U042_9FLAO  E=5e-32 s/c=0.53 id=23% cov=42%
MNKTFKILDCTLRDGGYYTNWDFDRELVKTYCSSMESLPIDYVEVGY-RSIPlegylgeyfyCPDFVMKELKQMMPSKKLVIIL--NEKDIRASHvpELLKPCQGYISMIRIAVDPA------------NFERAIELAKAIKVMGFEVAFNVMYMSEwKEDNSFLDLLEDL-DSIIDYFYMVDSFGGVFQDDVKDIIRLVKSK----TNVQLGFHGHNNLEMALANTITAINEGCEIVDATITGMGRGAGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4Z863(8-256:323) HMGL family protein n=4 Tax=Bacteria RepID=C4Z863_EUBR3   E=7e-32 s/c=0.57 id=21% cov=44%
MTARpdIRVLDATIRDGGLVNNFMFTDDFINALYRANVKAGIDYMEFGYKASKElfdvnkfgkwkfCDEAAIREIVgDNNSDMKISVMADVGRCDYKKDILPREDSVIDMVRV---ATYVH-----------QMPAAIEMIEDAKSKGYEVTCNIMAISNTQESDLDQALDMVAKSSADGIYIVDSYGALYPEQIRRIAEK-YTEIAEANGKFVGMHAHNNQQLAFANTIEAAAQGVSLLDATMMGMGRGAGNCAME-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6WZN8(11-267:293) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6WZN8_FLAB3  E=2e-31 s/c=0.54 id=20% cov=41%
------------RDAMQGWGEFIPTNKKIDYINSLIDVGFDVLDCGsfvSPKSIPQMADSgtvVDEIDKGISNTKLSVIVANFRG----AEKALQHQQIDILGFPFSISETFQHRNTNKGQEAAFEDIVKILQLVEADGRKLNIYFSMAFGNPYgemwkwEDVDFWAQRFSDIGIKNILLSDTTGTGTVEQIELLFSKIPAKYPDID---FGAHFHNRYEDSYIKLKAAYDNGCRRFDSAIKGIG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q583A8(7-318:431) 3-hydroxy-3-methylglutaryl-CoA lyase, putative n=5 Tax=Trypanosoma RepID=Q583A8_9TRYP  E=5e-31 s/c=0.44 id=20% cov=41%
------------RDAMQGLPHFIPTEQKIRYLKALLKCGFYALDCGsfvSPRAVPQMRDSTEVIANCWKTmqeekaaPKLSV-VVASLAGFKQALETP---GVSVIGYPIGCCERFQQRNAKKSIAMSLDEIRNIKEATDAfnaqrssnpvapnedvNGRELLIYISMAFGNPygeshsIDLVEKLVGELVASGARDISLADTTGVAQPPLIFDTFTQLRKKFP---DVTFAGHFHSNAVEARGKIVAALDAGCTMIDSALCGMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4HR83(2-263:330) 4-hydroxy-2-ketovalerate aldolase, putative n=2 Tax=Campylobacter RepID=Q4HR83_CAMUP  E=9e-31 s/c=0.52 id=21% cov=36%
----IQILDCTLRDGSHINNGKFGKEKIRQIITGLIEANIDIIEVGLLQNHQCgvDFsifnsiDFVDQCLSSIekKNSKFSLMLRTDRVDFNKLAKSPK---VDFIRIAL--------------YQEHLNDIKRYGEKAKELGYEIIFNPIAITKYSPNEIQFLIKTLEELKPYGISLVDTFGSFTLNEFEKVLKIFDKNL--SPNITLGIHLHQNLNLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1QUV6(45-297:315) Homocitrate synthase, omega subunit n=2 Tax=Clostridium butyricum RepID=B1QUV6_CLOBU  E=1e-30 s/c=0.54 id=26% cov=26%
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGNTPLEELLGALRY---VENINIRGDLRVFKKISKLYEEITCTSIPPTKPLIGTDIFNVESGIHVNGIIKNSKTFEPYNPEEVG-GERKIIIGKHSGIKSLKIKFEELKIEYNSECLDAILIEVRNQSNSKGRGLNDDEI---------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0CVP8(3-257:336) Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVP8_9CLOT  E=2e-30 s/c=0.53 id=19% cov=42%
---KIHLLDCTLRDGGYVNNWEFDNGVAKEIVNGLYKSGIHVIEIGIMghggkvgkstkFASFKEAESLLENRK--KDCKYAiMLNQAEAASFDIPARSEKT--VDMIRLAYFKSEFQNAIVLAKSL--------------KDKGYEVFLQAMATFMYSDDEMNDMLRQINDMKPKAFYIVDSFSNLFPEDIARMAKQVLLKLDK--DIDFGFHAHNNIQMAFSNAITFMDVESDRdiyIDGSIYGMGRGAGNVPIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4ZRW6(4-284:342) HMG-CoA lyase-like n=5 Tax=Proteobacteria RepID=Q4ZRW6_PSEU2   E=4e-30 s/c=0.48 id=24% cov=41%
----VKILDVTLRDGGYRNNFNFTEDQAQVITTGLANAGVDLCEIGYCKGSFAPkgehgltsdvgAVFIEKIAQAAKGrIELAVMVHPRNITTDD-LAMLKEQGVSMIRVCL--------------RRDQLDEGLVTLSLARDHGFSVSANVTHVTSQTPGSVLDTAVRAEGAGADIVCCADSNGHMVPTDVDRLFSRLSSRL----LVPLGFHAHNNLSLALANAAAAIEAGAEYIDTSICGMGKGAGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6L7H4(1-249:525) Putative 4-hydroxy-2-ketovalerate aldolase n=1 Tax=Bacteroides vulgatus ATCC 8482 RepID=A6L7H4_BACV8  E=9e-30 s/c=0.54 id=22% cov=43%
MS-KIQLLDCTLRDGGYINNFRFGKYAIRKILQQLTHAGLDIVECGFLEDGEYDedtsiFNAAEQIASLLPNehgrTMFVAMVCYGEYDLSQ-LSPCTRNSIDGIRVTF-------------HYDEV-EGALEYCREIKEKGYKVFVQPVGTSSYTDIQLLHLIEKVNELQPYSFYLVDTLGLMHKNDIARFFYLINTNLDK--SINMGFHSHNNLQLSFSNSQEFFEYVGDRVislDASIYGMGRGAGNLNTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6LKZ4(18-268:534) Putative uncharacterized protein n=1 Tax=Bryantella formatexigens DSM 14469 RepID=C6LKZ4_9FIRM  E=3e-29 s/c=0.53 id=18% cov=37%
------ILDCTLRDGGYINNWKFGGRTIKSIISNLEDAGVDIIECGFIRkedhssdssVFSSMEQVADIIAPKKANISYAIMIEQHNH-VDKLIPENDGNGADIIRI------TFRRK--------EWEEAKVAIKHLICKGYKVCVQPVGTVTYDDESLLKLIKDVNQIKPYAFYLVDTLGVMYRHDMRRFFYLIDNNLSK--EICLGFHSHNNLQMSFANA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4Z4L3(15-258:326) Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z4L3_EUBE2  E=4e-29 s/c=0.54 id=19% cov=42%
----IKVMDCTLRDGGLVNNFEFTDEFVKDLYEANVAAGVDYMEFGYKADkdifDEKEFgkwkfckeEDIRAIVGENDTPlKISVMADVGRTNMKRDIPPKSESVVDMVRV--------------ATYINTIPAAIEMANYCSDMGYEVTVNIMAISTAgENELDLALELLASQSKAQYIYLVDSYGSLYPEQVRRLADKYIK-IAEKYGKSVGIHAHNNQQLAFANTIEACSIGVSLLDATVSGMGRGAGNC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9LXD4(1-264:538) Putative uncharacterized protein n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LXD4_9FIRM  E=8e-29 s/c=0.50 id=19% cov=45%
MGER-LLLDCTLRDGGYVNNWEFGYDRIVEIFERLVSSGVEFIEVGF-LDEKSSFDRGRTV--LPDTASVSRMFEGVSKG-DALVLGMIDYGTCSIERLEPCEETFLDGIRVIFKESKMEAALKFYAEVKKLGYKVFAQMVSVTTYTDEKLAEYAKLVNEVMPYATSMVDTYGLLDEEHLCHIYGILDANLD--PQIRVGYHAHNNFQLGYANAKHFLSLDSERgllADGTLYGMGKSAGNAPLE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6KTK9(1-277:485) Oxaloacetate decarboxylase n=1 Tax=uncultured bacterium RepID=C6KTK9_9BACT  E=9e-29 s/c=0.47 id=22% cov=41%
MGDEIKIIDTTLRDGHQSLWAlNMRTGWMLPALDHLDRAGYEAMEFFVPVVqikkmirdlNEDPFQWLRLGTQRAKQTPLrlhagyrSGLGKVPESVSKLLVQMIIDQGITTARISEPWNDF---ETLKEEHDEMRRMGIESV---------VNIIYSVSPRHTTDYFVQRTRDAAALKPYRLCFKDVGGLLTPQRIRELLPKVLEA---AGDVPVEFHNHCTNGLGTFNVQEAVALGIRHVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5N919(155-350:353) NifV2 n=2 Tax=Clostridium kluyveri RepID=A5N919_CLOK5   E=6e-28 s/c=0.65 id=29% cov=32%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATAIAMEACSDGADFITAAFN--GQIYGFASLEEVVLGLKVIKKG---EVSGNLKLIGELAKAYTQLTGEKVYCMKAVIGEDIFKYESGIHVDGIAKNPYTYEPYNPYDIGEKRTMY-IGKHSGKKAVMLRLKELNIDYEGINGNNFLSRIREVSiKLKRNIFDEELIQI-------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C2FUC7(4-260:282) Possible hydroxymethylglutaryl-CoA lyase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FUC7_9SPHI  E=7e-28 s/c=0.50 id=22% cov=41%
------------RDAIQGLHGQISTEKKAAYINFLIRTGlFECIDFGsfvSPVAVPQmaDTEAVVRQLDLVNDTRLLAIVVNEKGVERAtAFEQIHYLG-----YPFSISEEFQRRNTNANLQQSYERLKYIVERTKAGDKEPVVYISMAFGNPYKEiwseqlVIDWLGNIAELGVTRFSLADTTGEASVAQIGSLFHKVYELFTELH---IGAHFHSTKLNSMAKIKAAFESGCKTFDGAMLGYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5LD67(2-173:198) 2-isopropylmalate synthase/homocitrate synthase family protein n=1 Tax=Streptococcus pneumoniae SP3-BS71 RepID=A5LD67_STRPN  E=2e-26 s/c=0.72 id=25% cov=30%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGHNDLGLAVSNALSAIESGADIVHTCTLGIGERCGNTSTEQLIINLIV--SECGRRATYKLRYLYDVAKILENKSQFPISPKTPCFGMDSFFTCAGTHASSLYKSylkndnnfSIIFSPYDSNIFGR-EVTVGINSQSGRSSIEYISRKYGLELSQENITSILGLVKQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7BI12(11-133:142) Pyruvate carboxyltransferase n=1 Tax=Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949 RepID=C7BI12_PHOAA  E=6e-26 s/c=0.98 id=25% cov=21%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNIDIGIKTEALKGLCEYVSKTTKIPLYPWQPIVGDNIFSHESGIHANGTLKNSASFEPFSPDLV-AGIRKIIVGKHSGKASIKYALEKLDISYKEHELAPLLAMVREVA---------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4T5R6(109-382:462) Chromosome undetermined SCAF9150, whole genome shotgun sequence. (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4T5R6_TETNG  E=1e-24 s/c=0.43 id=25% cov=40%
----LLLMDTTFRDAHQSlLATRVRTHDLKKISPfvshnfnnlfSLENWGerreelvnrlkVEEMlsatfDVAMRFLSECPWKRLQELRALIPNVPFQMLLRGAnavgytnypDNAVFKFCEVAKENGMDIFRVFDSLNYLPNML-LGMEA---AGAAGGVVEAAISYTGDV--SDPMRQKYSLEYYLKLAEELVRAGTHILCIKASgcrlplmrsqAGHGRPAEAGRsrlLVNALRDRFP---DVPIHVHTHDTAGAGVAAMLACAEAG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B6JVP9(570-785:1123) Pyruvate carboxylase n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JVP9_SCHJY  E=3e-24 s/c=0.53 id=26% cov=30%
-----LVMDTTWRDAHQSlLATRVRTIDLVNIAPftshalasaySLEMWGGATFDVSMRFLHECPWDRLRKLRRAVPNIPFQMLLRGANDMLNP------------------------KKKYNLT-----------------------------------YYLDLVDNIVAQGIHVLGIKDMAGVMKPRAARMLVGAIRAKYP---KLPIHVHSHDSAGTAVASMVAALEAGADVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2SNE9(20-235:333) HMG-CoA lyase-like protein n=1 Tax=Streptomyces fradiae RepID=D2SNE9_STRFR  E=2e-23 s/c=0.52 id=26% cov=41%
----VQVTDVTLRDGGYLNDHSWTADRAHAVVRAVSAAGVRRIEVGYanaGAAFPSPALLGDLVAAAGP-ATVVMMVKPFGDEPD--WAALAGRGVGAVRFPVAVARA--------------AELGPVLDRARRAGLETAVNLIRVSAEALDSVVGAAVAAAELGAGTLYVADSNGSLTPHATDELVRALCRAVP----VPIGFHGHDNLRLALANSLAALRAGAAHVDASFDGIGKGGGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B1MF23(20-310:419) Possible 2-isopropylmalate synthase n=1 Tax=Mycobacterium abscessus ATCC 19977 RepID=B1MF23_MYCA9  E=4e-21 s/c=0.36 id=23% cov=44%
------ISDETMREGGERAPFGATDDQKIQLIRAITDAGITDIDVGSGI---TEASFVRALLDaQQLESTIAPDATFSFNLTLKTWEPLCEQLERELPSSY-LSDIYVSIGMIEIDSEN-RLFERVAERLRSIGVgKLRSSLLNAFSITVDEqkyehLNTQIERCRQQGISLIRINDSVGTLVPDSTAVLAANL---VRDNPDITFYLHGHNDRGLGTANSLTSVFHGFQMIEGGVAGVGNRSGLAEIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4S9P1(23-265:409) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Yersinia mollaretii ATCC 43969 RepID=C4S9P1_YERMO  E=1e-19 s/c=0.41 id=19% cov=42%
-------LDETLREGAERCPFSVPTRHKIPLVSKILDTGIRDIVYGSGPNDPTHLiDVIYELHSHGKLPPetqfsFIMLLNCHDPIMPQLKNYPEELKKYLTISFGMISYQSGKKLFERTVEilrvWGFDRFRVSLLNNFSAGID---------EASYEKITAEIARSLAMEIETVRINDSLGTIYPEDMAILAANLRNHYPNMN---FSLHAHNDRGLGLQNALSSLYHGFNIIEGGFAGTGNRSG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2MJY3(3-405:405) 2-isopropylmalate synthase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MJY3_9BACT  E=1e-107 s/c=0.97 id=47% cov=76%
---------------------------------------------------------------------------------------------------------------RTTPEDTLRMATAAVAYAKSLCEDhpdanVEFSPMDAGRTELAFLYEVVEATIAAGATVVNIPETVGWTVPTEFGNLIKSIMENVPNVDDAIISVHCHNDLGLAVANSLIAIEQGARQVECTINGLGERAGNTSLEEVVMAIRTRRDYFkNYYTEINAKEIVPISRRVSRTMGIAVQPNKAIVGANAFAHSSGIHQDGIIKSRVTFEIIDPQEIGWKESQLILSPRSGRNALRHRLSELGYEVEGAQLDKVYERFLKVADKKKSIQDADLEAIMSD-EIRAIPAIFELDYIQVVSGTKISPTTTVGIRTEDGVVEKASTGDGPVDAAFKAIAQVVDIQLNLVDYQIRSVTEGEDAIGEVSLKVQDNGHIITGHGASTDIIEASARAYIHAVNKLIQIRSEG-----------------
>UniRef50_A0LSS5(18-526:554) 2-isopropylmalate synthase n=12 Tax=Bacteria RepID=A0LSS5_ACIC1   E=1e-105 s/c=0.75 id=28% cov=93%
-----QVYDTTLRDGAQGEGMALTVADKLAIARHLDDLGVGFIEGGWPGALPKDTEFFRRARTEltLRNAVLVAFGATRKPesrvEADPQVLALLEAETPAVCLVAKSHVRHVSEALRTSLDENLAMIRDTVAFFRREGRRVFLDAEhffDGYAADPQYAVECVRVAAESGAEVVVLCDTNGGMLPPRIADVVHEVAER----TGVPLGIHCHDDTGCAVANTLAAVDAGVVQVQGVVNGYGERCGNANLITVVANLELKMGRRVLPPG-RLAELGRVSHAIAEVANQPPRANQPYVGLSAFAHKAGLHASAIKVSPDLYQHIDPALVG-NDMRMLVSEMAGRASVELKSRQLGFDLSgqRDAVSRIVERVKNLEARGfmFEAADASFELLLREELDGVPTRFFDLESWRViverRADGEVVSEATVKVVVKGERIVATAEGNGPVNALDRALRQALERlypqlaELELVDYKVRILdgSHGTGAVTRVLIETSDGETEWTTIGVDGNVISASWQALDDA----------------------------
>UniRef50_D1XS06(74-606:612) 2-isopropylmalate synthase n=1 Tax=Streptomyces sp. ACTE RepID=D1XS06_9ACTO  E=1e-104 s/c=0.71 id=23% cov=94%
LTRAPLWVPVDLRDGNQALAEPMDAARKRRMFDLLVAMGFKEIEVGYPSASETDFGFVRHLAESgavPDDVTVSVFTAARSDLIDRTIASVEGLPRTLVHLYTATAPVWRDVVLGRSRAELHAMITDAAtHLLRRAGerpgadIRFEFSPEVFNLTEPDFVLEVCDSLTELWeaspdrPVVHNLPATVEIATPNVYADQIEYMHRHLARRDSVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDLVTLALNLFAQ----GVDPMVDFSDIDAVREVVEHCNRLPVHPRHPYGGELVHTAFSGTHQDAIAKGMArhakraaeqgvpaaeapwevPYLPVDPGDIGRTYEEvIRINSQSGKGGVAHLLRAhHGLDLPQAMRPDFSRTVQRVTDGTGRELTAGELGELFRTTYLAAAGQgsVEAVSWSTAETAPGVHTFTCVLRVDGREHSCRGTGNGPLAALTDALRTA-GVTVGVLGYWEHATTAGPDSPAAAYAECRVDGVTAWGAGWDTSVLTASVHSVLSAVNR-------------------------
>UniRef50_Q2JTM1(1-353:395) Homocitrate synthase NifV n=7 Tax=Cyanobacteria RepID=Q2JTM1_SYNJA   E=7e-95 s/c=0.99 id=34% cov=67%
MNSSITINDTTLRDGEQAAGVAFQIPEKISIAALLDAIGVPEIEVGIPAMGAVETEAIRAMLSLGLRAHLLGWNRAVPSDILASIR----CGLKRIHISVPVSDRQIAAKFQGDRPRLLRQLRQCVEMALEQGLWVSVGAEDASRTSLEQVIELAQMAQSWGCRRFRYCDTVGVLDPFSTYKQIRRLVRAI----DIPVEMHTHDDLGMATANALAGIRAGAQSVNTTVNGLGERAGNAPLEEVVMALRC---TLGIDVGVDTRRLRELSQQVARASGAPLPPWKAIVGDNAFAHESGIHAAGVLRDPQTYEPFPPEAVG-SQRRLVLGKHSGRHLLLQILKEHGIpveQIPPGQLEKLLEQVRQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2LHQ1(30-386:427) Homocitrate synthase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LHQ1_RHOVA  E=3e-82 s/c=0.86 id=34% cov=68%
LSGRVAINDTTLRDGEQTPGVAFTAAEKMQIAAALADVGVDEIEVGTPAMGRDEQEAIRRIAKAGLPLRVIAWCRMRRGDVDDAI----ASGVSIVNLSAPVSRFQIAAKFGGSLPRVVAAVTDVIGYARAKGLEVAFGGEDSSRATRDTLEPILEAAARAGAVRYRFADTLGVLDPISIRAAIEAVRR----ITDLPIEFHGHDDLGLATANTLAALEAGASAASVTVNGLGERAGNAPLEQIAVALDS---LFAQATRIHLPALGHLSELVARCSGREIARSAPIVGKDVFTHESGIHVDGILKSKDCYEALSPRRLGRN-HRFVVGKHSGLAGLRHELSYLGLQLTEDEERRLLAAVRGYAEKHK-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q04QM8(36-410:435) Isopropylmalate/homocitrate/citramalatesynthase n=15 Tax=Leptospira RepID=Q04QM8_LEPBJ  E=1e-73 s/c=0.74 id=33% cov=68%
-----FFMDVTLRDGNQALRKPWDLDQKETIFKQLIKLGVQGIEVGFASSNSQEFKTCSRLSSiAPDNVVISSLSRAVEKEIKISWKAIRHASKPRIHIVYPISAFTIQNVLKLSPEKVLEKISESVSFAKSLVgskGEIQFSGEHFGDSleNLDFAVEAFRTALNYGADIINLPNTVERYRPWLFVSMVKAVRNVLPE--NAKISVHTHNDLGMATATTVESYFSGAVQLETALNGLGERAGNTNTYEVAIAL----HNCGVDVPLNLSAIYETSRLVSYLSNVPIYEKAPLVGEDVISHRSGIYQDGVAKTRHlskgAYRAFNATLIGRPEEdRIEFTSQSGRSAIFCILKDAGEDITLEQAGKLQPILKKISE--------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2JWV4(68-403:465) Putative homocitrate synthase n=1 Tax=Filobasidiella depauperata RepID=D2JWV4_9TREE  E=3e-65 s/c=0.75 id=27% cov=60%
------IIESTLREGEQFANAFFNLETKIKIAKMLDEFGVEYIELTSPAASPESRAHCEAICKLgLKKTKILTHIRCHMDDARLAVE----TGVDGVDVVIGTSSFLREHSHGKDMAWI-------------------------TKTTVD----------KIGVNRVGVADTVGCADPRQVYDLVRTLR----GVVSCDIETHFHNDTGCGkastldestapIANAYAALEAGATHVDTSILGIGERNGITPLGGLIARM-MVADPDYVKSKYNLTMLRELENTVAEAVEVQVPFNNYITGFCAFTHKAGIHAKAILANPSTYEILNPADFGMTRYVSIGHRLTGWNAVKSRVEQLNLNLTDEQVKDATAKIKELAD--------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8DR73(2-383:455) Pyruvate carboxyltransferase n=3 Tax=Desulfovibrio vulgaris RepID=B8DR73_DESVM  E=8e-65 s/c=0.65 id=28% cov=66%
------LLDTTLREGEQSFGTYLSMADRERVLRGLAAVGVPEAEVGWAGR-EDLTDMLALSARVAPGLAAAAWCRCRPGD----LRAAVACGASRVCVGVPVSDAHLARRLGLGRAALLDLLAATLAEARMLGIEhVTVGMEDASRADRAFVFAVACHAAAHGAHRVRLSDTVGLYTPLEVADVVRALRAELegarqddtaPRARRVSIGTHFHNDCGMATANALTALECGADCADVSVLGLGERAGVARLEELAAALVVRG-----RARFELAPLRALCGQVAQAASLSVPRHWPVAGRDIFAVESGLHAHGVRRDPSLFEPFPPELVG-DSRRMGVGRKSGVAAVAAALAELSILPPPDELPAIVEAVRDL----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6FZR1(2-382:382) Homocitrate synthase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6FZR1_9DELT  E=3e-64 s/c=0.65 id=31% cov=66%
-----RLVDSTLREGLQSDTRPVDSARKLDIAALLAAFGVDCIEVGNPVSSERARADARRLAGLDLGsTRVLAHVRCHPEDIRAAVD----TGVDGLNLFIPCSPLLRHASLGRSLDELIEIAVGALELARALrpELELRITPEDSFRTPVPELERFCGAVtSRVRVDRVGLADTVGVAHPRAVEARFARLRQRF----DLDLEFHGHNDTGCAVANALLAREAGATHVDVTVLGLGERNGITALEGFVAAL-LVHDPDAVHGRLRLELLPLLTRAVADAFGVEIPRNSCLVGANSFAHKAGVHTNAMLRDRRSYEFVDPQLMGVERRLLAGHEMTGASVLGARAQALGLDLSPEQLRRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2FZS6(2-381:381) 2-isopropylmalate synthase, putative n=51 Tax=Staphylococcus aureus RepID=Q2FZS6_STAA8  E=5e-64 s/c=0.65 id=30% cov=60%
----IRIQDNTIRDGMQQSNVRKSLIIKKEVLKQINKLNINSVEVGMCTTIEDEFNIhqFRDILS--PEKELVVLTRLNEKEIKKIVKLKIHN--LVVKILLPISDLHIKEKLNFSNKYYIQKIKDCLDILKKDKKGVDICFEDGTRTSREKLKEYMEIISKYQVRTVTFADTVGCSTPLEYGDIFNYFVKKY---SNIIFSAHCHNDLGLATANTLAAILNGAKQIETTFLGIGERAGNAPIEEIITILTKKQIE---STEFTLPDVYKTSINISKILDFQISENKPIIGENIFKHESGIHQDGTKKNINMYQYLVPSDLGLKNSQVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8A943(60-461:488) Pyruvate carboxyltransferase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A943_IGNH4  E=7e-60 s/c=0.58 id=25% cov=59%
LPSEIWITDTTFRDGQQA-REPYTVEQIVRLYKYLHELGgplgkIKTTE--FFLYTEKDKEAVRRVKELGYKYPIpTGWIRAKKEE----LSLVKEAGLEETGILASISDYHIYFKFKASRGKVVEKYLSVVEEALKMDIIPRVHLEDITRANIfevvvPFVRKLMKLSERYGLPVkVRYPDTLGVGVPIVEAMLprsipkLTWVLRHVCGVPSEWLEFHGHNDFHLGVANAVSAWLYGAGLNNGTLLGIGERAGNVPIEALVFAYAQLKHGFD---GMNTKVITEIAKYYRDELGYEVPPYYPIVGRNFAVTRAGIHADGLLKNPETYLPFDTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q28KR2(8-296:319) Hydroxymethylglutaryl-CoA lyase n=5 Tax=Alphaproteobacteria RepID=Q28KR2_JANSC  E=4e-53 s/c=0.73 id=23% cov=41%
------------RDGFQSEKTFIPTARKIEIANAMFAAGLRHIQVTsfvSPRAVPQLADAAKLIAglDRPDGAVVSALIPNLKG-----AERAAAAGVDAVHTVVSASETHNLKNVNRPIDQSLADFEDVAKLMHREGIVVEggmataFGCPFEGVVPPEQVARIARRYQDLGAKRVSLGDTTGMATPTTVRAAVRAIRAEAPG---VEICLHFHNTRGVGLACVMAGLAEGVSYFDAAIGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0MGG7(3-292:311) Pyruvate carboxyltransferase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MGG7_RHOM4  E=1e-52 s/c=0.72 id=22% cov=41%
------------RDGFQYETTFIPTERKVAVIERLVEAGVRRIQVTSfvhPKWVPQMADAEEVCRRLPdrDDVIFSGLALNVKG-----VERAHAAGLRYVDLSIATHDEHSLANANMTVAEAVRQAEAMIRLAHhydmqpQLGLQTVFGYKQPGDTPLQRIRELARRFVDLGLESFSLADTTGMAHPVQIQEYVEAVREEI---GDTPLVLHLHDTRGMGLANVLAALQCGVTRFDTSLGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4X0W1(1-286:303) Pyruvate carboxyltransferase n=3 Tax=Actinomycetales RepID=A4X0W1_SALTO  E=1e-51 s/c=0.72 id=22% cov=49%
------------RDGLQNE-EPIPTEAKVRLLDALSRTGVGRIEAVSfvhPKAIPQMADAdeVWRRAEQTEGVRYSALVPNTRG-----AHRALAAGFTEIEVVVSASDTHNRRNVNRSTEESLDDIAELVELLHHAGARAEviiatsFGCPYEGDIDPVRVAGIVDRVVRDGADRVAFGDTTGMATPRRVRELVTAVRDR---DAHLPLLLHFHNTRGAALANLLTAIELGVTEFDASVGGLGgcpyapGASGNLATEEAVHLL----HDMGVDTGIDLAALIEVAELAEELVGRSLP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8WQC0(1-290:301) Pyruvate carboxyltransferase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WQC0_ALIAD  E=4e-51 s/c=0.71 id=25% cov=43%
MGERVWLREVGPRDGLQNEPGVIATEIKVELVERLMDAGVRFIEVSSfvhPKWIPQlaDADEVFARIRRRPGVELSALVPN-----ERGLARALAAKVDAVHVFMSASESHNLKNINKTIADTYPVLRPVIEGAKAEGLVVRgyvstvFGCPYEGKVPVSQVLSVVERLFELGVDEVALGDTIGVAVPTQVAEVVREVERIVPLDR---VSLHFHDTRGMAIANMYAGFAAGVRRFDGSIGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6JJQ3(3-299:303) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Bacteria RepID=C6JJQ3_FUSVA   E=1e-49 s/c=0.67 id=23% cov=51%
LPEKVQIVEVGPRDGFQNIKTFIETKHKLEIIDSLEEAGCNKIEITSfvnPKWIPQMVDSKEIcetcVKKNERKYEVIVLCPN-----KKGIENAISSGAEVISVVISVSEAHNKANVNRTVEESFKELEEMVYKYPnmkfRLDLATVFGCPFGEEIKPERVSELIEKAKKIGVKEIMLADTVGLGNPVLVEKILKQVKEQVGTENII---LHIHDTRGMGLANMLVALQLGYSIFETSIGGLGgcpfapGAAGNVATEDFVNMLN----GMGINHNIHLEKLYHTLDLIDQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B4BIN3(1-281:300) Pyruvate carboxyltransferase n=1 Tax=Geobacillus sp. G11MC16 RepID=B4BIN3_9BACI  E=2e-49 s/c=0.71 id=23% cov=51%
MPD-VQIIDVSPRDGLQNEQVIVSSEKKRMLIEMLVKSNIRKIEATSfvhPLKVPQMADAeqVLKLCEELSEIELVALIPNLKG-----FQRAKQTKISEINWVTAATETFNYKNIGMSIEDNFAQFKQLVQESRTLNITicfsiaVSFGCPYEGKVSPVKVISLVERAIEAGANRIGIADTIGIATPKQVKELLTEV---LHIAKSIPIAIHLHDTRGMGLANAYAALEAGVKIFETSASGIGgcpfapGAAGNLATEDLVYM----FERMGVKTGIDFEKLLDAADFAASLT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1VTK3(33-307:744) Pyruvate carboxyltransferase n=109 Tax=cellular organisms RepID=A1VTK3_POLNA  E=9e-49 s/c=0.72 id=26% cov=43%
-SPEILISEVGPRDGLQSVKACMPTADKLRWIDALYAAGVREIEVASfvpARLLPQMADAAEVVRHAItlPGLRVMALVPNRRG-----AEAALAAGVHKLTVPVSASAAHSLANVRRTREEMVEEVRAIAALRRDLaphvgleaGISTAFGCTLQGLVAEDDVIRLAAQCIAAGADESGLSDTVGYANPAQVRRLFRRLRAEIGRHAG---AAHMHNTRGLGLANCLAAYEEGVRTFDASLGGLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2S361(3-284:307) 3-hydroxy-3-methylglutaryl-CoA lyase n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S361_SALRD  E=2e-47 s/c=0.68 id=22% cov=43%
LPQSVALCDVGPRDGFQFEEQFIPTDRKVDVITALADAGLPRIQVTSfvhPKWVPQMKDAEAVCSRLPDraDVTYAGLALN-----QRGLERAHAAGLSQVDLSIATHDRHSQDNANRTVDEAVAQADDMVRYAHEHGLAVQmgfqtvFGYQAPGDTPLDQVVDMSRHFADLGVESLSLADSTGLAHPRMIKERVRAVQAAI---GDTPLVLHLHDTRGLGLANVYAALQCGVERFDTSLAGMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8ELJ7(8-290:318) Hydroxymethylglutaryl-CoA lyase n=1 Tax=Oceanobacillus iheyensis RepID=Q8ELJ7_OCEIH  E=2e-46 s/c=0.67 id=22% cov=51%
LPTKAIICEVAPRDGFQAEPEWIPTDKKVEMIRSLAKTGITTMEVTSfvhPKAIPQlkDAEEVVSRVHDIENLHLRALVPNLTG-----AQRAVNAGVKKLKLMLSATDSHSLSNANATVIEAQNKLEPIIEYANQNDtkvggsISVAFGCPYEGKVGVNQLIPILDRYQKMGIEEVSLADTTGMATPKQVYETLGVLKETYPTLT---FSMHFHNTRGMALANTISALQQGVIRFDSSIAGLGgcpyapGASGNVATEDLVHFL----HENGVDTGINLSSVITTAKEVKNIIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2W8A2(32-377:395) Hydroxymethylglutaryl-CoA lyase n=2 Tax=Pleosporineae RepID=B2W8A2_PYRTR  E=1e-45 s/c=0.54 id=21% cov=52%
-ADHVRIVEVGPRDGLQNEKKTIPLATKIELVERLARTGLTTIEAGsfvSPKWVPQMansAEILERLLSSPPHSshpiTYQWLLPNVKgfDNFLSTWQSKSQSGHDayptpppspgtdngpalntsssdpnampsassgadamnknhnstppihELSIFTAATESFTQKNTNCSIAESLKRFEPIMSKAKEMNLNVRAYISVALGCPYEgpdvdphKVAELAVSLLEMGADEISVADTTGMGTAPKTLELLKTL--NAAGVDKSDLALHFHDTYGQALVNSVVALEHGIRTFDAAVGGLGgcpfspGATGNIATED----LVHCFHSLGAKTGVDIEKLSEVGEWISQELGRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1Y2H6(3-285:300) Hydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase) n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y2H6_9BACT  E=1e-44 s/c=0.65 id=20% cov=44%
LPKKVLISEVAPRDGWQNHPVPIPTETKIKYIEKMVDCGARKMEITSfvnPKYVPQMgdaREVFRGARSYLEEHGVTAFALTLN---QKGVENAREAGFTHVEFVLSVSEEHNLRNSRRTIRESLDAFKELAANAEGlhiiLAMPCVFGSPFGDEVPVERVKWLIDEAQSVGVAEFGIADTAGISTPENTRRVVTAIREY---TDLSKVSLHMHDTYGMGLANCYVAMEEGITMMDSSLAGMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IW44(46-399:436) HMGL-like domain protein n=4 Tax=Bacteria RepID=Q1IW44_DEIGD   E=2e-44 s/c=0.52 id=24% cov=63%
---------TTHRDGQQG-GLPLTTADGLAIYDLMGKFTGDSgaIrQAEFFVYRPADRAMLEGALERWRGghpVEPTTWIRATRRD----AELVAELGVRETGMLASASDYHTFYKFTPgGRAQAARTYLDAVRAVLDAGLRPRLHLEDATRAPREFILPFVAAVQevsapygEAQAPKFRVCDTMGVGLPLEgvawprsVPGMIRELVAA--GVPGEQLEFHPHNDTHLVVANCLAAVIAGCAAINGTLLGKGERTGNAPLEGVLLHLIGLNLLLGQP---DYRALNELADLYERL-GQGVPAKYPLYGRDAHRTRAGIHADGLNKFWPMYAPFDVPQLLGRPLELSLTKDSGLAGLIFLIKQHaGVELDK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A9HXH6(1-304:313) Strain DSM 12804, complete genome n=3 Tax=Bacteria RepID=A9HXH6_BORPD  E=2e-44 s/c=0.60 id=20% cov=54%
MTRDVVLCECFARDGLQHEARFIATPAKVGLIQRFADLGFDRVEATSysnPSVVPQFADASELLAGLPRraGVWYKATCANVRAVERALHDLDAGHGANEISLLVSASESHSLRNLKRSRRDQWDNIAAMARRAAGRfrmvgTISVAFGCPFEGAVDAARVLDNARRFAELGVDLVTLGDTTGMASPPAVRNLYRTLQLEFPQMTLVA---HFHDTRGTGLVNYVAALDAGVRYFDSAFGGVGGHPdkvkyggghtGNVATED----LVSLFESMGVRTGLDLAGLPAVSRLCQEALGRELHSRVAAAGLN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0TEI2(5-297:643) Oxaloacetate decarboxylase, alpha subunit n=27 Tax=cellular organisms RepID=B0TEI2_HELMI  E=2e-44 s/c=0.62 id=22% cov=40%
--RRVKITETTLRDGHQSLwATRMRLEDMLPIVEKMDKVGYHSVEVWGGAtfdvcmryLNEDPWERLRILKKYFRRTPLQMLLRGQslvgythypDDVVEAFVHKAVENGIDIIRIFDALNDIRNMEA----PMRHAKKAGAHVQAAIVYTISPVH--------TMEHYVETALQLAEMGADSLCIKDMAGLLLPFKSRELVTLIKEKV----NLPLQLHTHYIGGMAVGALLKGVEAGADIIDC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1IM73(18-293:520) Conserved carboxylase region n=7 Tax=Bacteria RepID=Q1IM73_ACIBL   E=2e-42 s/c=0.64 id=17% cov=41%
MGRIIEVTDLILRDAHQSLmATRMAMEDMVPACEDLDNAGYWSLECWGGatfdscirFLNEDPWERLRQFKKLLPKTKLQMLLRGQnllgyrhyeDSVVERFVAKAAENGMDVFRVFDALNDI---RNLQTSIK-AVKKTGKHAQGTISYTISPVHTITAF--------VEMAKQLKEMGCDSICIKDMAGLLKPQPAYDLVKGIKEAC--GDDMLVHVHCHATTGVTLVSLMKAVEAGCDMV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1TPI3(6-294:308) Isopropylmalate/homocitrate/citramalate synthase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPI3_9BACT  E=3e-42 s/c=0.61 id=24% cov=41%
LPSRVEIREVCPRDGFQSVKEKISTKDKIALIDAMAETGVSVMEVTsfvSPKAIPQMSDASEVMThfneRWSGKVKSVVLVPNVRG-----AENALKVSPDSLNFVLSASASHNRANTRRTIEESLAELKEVKSLCgdVELGLSVAtsFQCPFEGAISPDAVVNIVEKAMEIGVGTVTLADTIGTCDPIYLSLTLSQIKKVFGDY---PFFLHLHDTHGMAIINTMAAMEMG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1DTS7(20-314:647) Pyruvate carboxylase subunit B (Pyruvic carboxylase B) n=9 Tax=Bacteria RepID=C1DTS7_SULAA  E=8e-42 s/c=0.59 id=21% cov=40%
-PKPIKITDLTPRDGQQCkLATRVRTDDLLPLCEKMDKAGFYAVEV-WGGATfdvclrylkEDPWERLKRIKEVMPRTKLQMLFRGQnivgykpksDKVVKKFVEKAIEHGITVFRVFDSLNDNRN--------------IEVAVKAIKEFGGEVhaEISYTKSPVHTLEKWMSYADELIDLEPDWICFKDATGILMPEDTYNIIRGIKQKIKEKanDRIKLVLHNHDMSGTAIMNHMMAILAGVDMV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1B8I0(7-273:347) 4-hydroxy-2-oxovalerate aldolase 2 n=5 Tax=Bacteria RepID=HOA2_RHOOB  E=3e-41 s/c=0.64 id=23% cov=42%
--KKITIVDTTLRDGMSSVSHQFTPQNVADIARGLDRAGVGTIEVAhgiglgassiqYGFAAATDPDYVRAAVDAVENADIAALYVPGIATL-AELQKAIDAGIKTVRVAVHCTEA--------------DCGQQPVEWAKEQGLTVMTFLMMSHKLDPEPLAEQAAKLDSYGADVVYVVDSAGAMVPRHAGDRVAALRQAI----SADIGFHAHNNLGVGIANALTAAENGATFIDGSLRGLGASAGNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5VE99(26-295:516) Pyruvate carboxylase subunit B n=3 Tax=Corynebacterium RepID=C5VE99_9CORY  E=4e-40 s/c=0.62 id=20% cov=40%
-PRKIGVTEVALRDAHQSLfATRMALEDMVAACDDIDKAGFWSVECWGGatfdacirFLNEDPWKRLRTFRELMPNSRLQMLLRGqnllgyrHYEDmvVDKFVEKSKENGMDVFRVFDALNDPRNLERAMTAVKKVGGHAQGTICYTVSPLHDV------------DGYIKLAGQLLDMGADSIALKDMAALLKPQPAYDIIRGVKDTY--GDDVQINVHCHSTTGVTLVTLMKAIEAGADVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8G187(2-258:333) 4-hydroxy-2-oxovalerate aldolase n=1 Tax=Desulfitobacterium hafniense DCB-2 RepID=HOA_DESHD  E=6e-40 s/c=0.65 id=27% cov=46%
--KKVKIFDLTLRDGSHAKSHQFTPEQMAVLAEQIDSTGVAAIEFGhgnglggsalqYGFAAATDREYMEAVAPVVKNADLSIIILPGVG-TRHELHLAKEFGAKYARMCTQITE--------------VDIAEQHIKMAKQLGMIPIAVLPCAGIIPVKDTVRYTQMAESYGAEVIYLLDGGGYQLPEQTYERIAAMKKAV----DVPIGFHGHNNLQLAVANSKAAVEAGAEYIDCCLKGFGAGAGNCPTEIFAAVM----DRMEIDCGIDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5KLA2(165-499:529) Putative uncharacterized protein n=1 Tax=Filobasidiella neoformans RepID=Q5KLA2_CRYNE  E=1e-39 s/c=0.50 id=22% cov=50%
--RYVRIVDVSPRDGLQNLkGKPVPTEVKRELVERLLEAGVRNIEVGSFVRSdwvPQMADTPqllpllppftgktlsppspvsrsespfsgrpsspsigpligEHLPPHAEDVHYPVLVPNMRGldnLIKLQEEWSskgLPALTDEIAVFVSATEAFSQANNHAPISKVLDSLPSVINKAKSHRFRVRGYvscvitCPYSGPTDPNQAVDVAERLLQMGCYEVSMGDTTGEGDPDSWKILWDRMKDR--GLDMDKIAAHCHDTFSLALSSILSLVPYGLKTIDSSLAGLGgcpyspGATGNVPTEDVVYAL----HKMGYETSIDLDRLVE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2UP73(4-269:507) Methylmalonyl-CoA carboxytransferase n=4 Tax=Verrucomicrobia RepID=B2UP73_AKKM8  E=1e-34 s/c=0.56 id=20% cov=37%
---------TVLRDGHQSLaATRMKTADMLPIAPILDSMGFsaletwggATIDAGLRFLKEWPFDRLDALKKAAPKTPHMMLLRGQnivgytnyaDDVVEAFVAMSAKHGMNIFRIFDCVNDPRNM--------------ETSIRAAKKAGAQ-AHGTICYTTSPVhttQTFVDMGRELADMGADAIVIKDMAGLIPPYVTQELVSALKKDL----NIPVWIHTHDTAGLGASTYLSAIDAGVD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0WAZ1(25-287:465) Oxaloacetate decarboxylase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WAZ1_9FIRM  E=3e-34 s/c=0.57 id=19% cov=35%
----VRLVSCDLRDGQQaAIATRMTTEEMLPVLKPLDEFGFDALEVWGGatfdacirFLGEDPWERLRIIKAHVKKTPLRMLLRGQnllgyapypDDVVDHFVAAAARDGIDIFLIFDGLNDVRN--------------VRRAAEAALKAGKKVEANLQFTSSpvHTVESFIKTARDYLDIGATALHLEDMGGMKTPREAVETVKALKATF----DVPVHYHAH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7YVE0(36-257:479) Homocitrate synthase n=1 Tax=Epichloe festucae RepID=A7YVE0_9HYPO   E=6e-34 s/c=0.67 id=26% cov=36%
---------------------------KIKIATTLSDFGVEYIELTSPVASQQSQDDCEAICKLGLMAKILV---------------ACDTGVDGVDLVIGTSSFLREHSHGKDMVAIEKAAIEVINHVKSRGVEVRFSSEDSFRSDLVDLLQLYRAVDRVGVNRVGVADTVGCATPRQVYHLIRTLR----GVVSCDIEVHLHNDTSCAIMNSYAALKASATHINTSMLSISER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C34E31(19-267:351) hypothetical protein ClM62_09706 n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34E31  E=8e-34 s/c=0.59 id=21% cov=42%
--KKIQLMDCTLRDGANVVGKGFSAEITDMVLDGLTSCKVPIIEfgnAGGIGAYEvagftnalTDSEYLEIAKKYLnRGSEIGMFLNAKR-YREKYVDMAAENGLAFLRVGADAGDGSI--------------ALQAIADIKKRGMKAYYSAMKAYLLTADELAEEGKRLEEAGLDEITIMDSAGTMLPEQVAEYTRKLSEAV----SIPVAFHCHNNLGLSAANAIAAFENGADILDCGLMGMARSAGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A3Q4B9(13-271:363) 4-hydroxy-2-oxovalerate aldolase 1 n=45 Tax=Bacteria RepID=HOA1_MYCSJ  E=1e-33 s/c=0.56 id=25% cov=48%
----VRMTDTSLRDGSHHKRHQFTKDEVGAIVAALDTAGVPVIEVThgdglggssfnYGFSKTPEQELIKLAAETAKEAKI-AFLMLPGVGTKEDIKEAQNNGGSICRI-----------ATHCTEADV---SIQHFGLARELGLETVGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAEL--GDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVE----ALIGVFDKIGVKTGIDFFDIADAAEEV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q89WI9(10-287:315) Blr0698 protein n=1 Tax=Bradyrhizobium japonicum RepID=Q89WI9_BRAJA   E=3e-30 s/c=0.49 id=22% cov=50%
-SDRVSLREVGLRDGLQLVKKFPSTEAKQRWVREEYAAGVRHFEVGSflPAKTFPQFVDVRDVIGAVANLP-GAHGIAL-ALNERGVNEALESGVGEIASVVSATEEHSQANAHRSRDSAIANVRRLCEMrdasshkpLVNAAISMALGCSITGAVDPAEVLRLVDKCLEAGVDFVAIADTVGYAGPKQVAELSRA---AVKLAGQKPICIHLHDTRGMGIANAAAALDEGVRIldgslggLGGCPFAPG-ATGNVVFED----LVFLCESKGFATGIDLEKLVGVRRI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0PQP5(5-140:156) 2-isopropylmalate synthase (Fragment) n=2 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=Q0PQP5_9GAMM  E=4e-29 s/c=0.97 id=59% cov=24%
----------------------------------------------------------------------AGLARALDKDIERAGEALKEANSGRIHTFIATSPIHMEQKLRMSPDQVVEQAVAAVKRARNYTDDVEFSAEDAGRSELDFLCRIFEAVIDAGATTLNVPDTVGYAMPDQFGETIRALRERSP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI00017F0C36(3-166:401) PREDICTED: similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 n=1 Tax=Sus scrofa RepID=UPI00017F0C36  E=1e-24 s/c=0.71 id=24% cov=24%
------------------------------------------------------------------------------------------AGATEVSVFGAASESFSKKNINCSIEESMEKFEEVVKSARHMNIpargyvSCALGCPYEGNITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKKILESVMKEIPPR---ALAVHCHDTYGQALANILTALQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q0RSV0(570-844:1172) Pyruvate carboxylase 2 (Pyruvic carboxylase 2) (PCB 2) n=3 Tax=Actinomycetales RepID=Q0RSV0_FRAAA  E=8e-24 s/c=0.41 id=24% cov=40%
--------DTTLRDAHQSlLATRLRSFDILAAAPsfaaltpnllSLEAWGGATYDVALRFLAEDPWERLAALRSTAPNQCLQMLLRGRnavgytpypDDVVRAFVAEAAATGVDIFRIFDALND---MEQMRPAIEAVLETGTAIAEGTLCYTGD--LSDPGEQIYTLDYYLRLADQLVAAGVHVLAIKDMAGLLRPAAAATLVTALRERF----DLPVHLHTHDTAGGQLATLLAASAAGVDAV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2G774(1-285:490) Pyruvate carboxyltransferase n=2 Tax=Proteobacteria RepID=Q2G774_NOVAD  E=3e-23 s/c=0.39 id=17% cov=40%
MTE-IRLVDVTMRDGNQSLwgATGLNTAHMLQAAALTEACGFRAIDFTSSSHMAvavryfqnNPWERLRRMAAAMPTTplqfittglRFIAWQQADPEFMRLVYRALQANGVGRFVLLDPMHE--------------VPAVIEAAKLVKEEGnaeVMAALTFTLSEIHTDQFYADFARAVGQSPnIDLFYIKDPAGLLSVDRARTLVPAVKAVIGNR---PLEIHAHTTVGQGMMASLEAAKLGISAIHV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8RV44(3-262:533) Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RV44_9CLOT  E=4e-18 s/c=0.37 id=21% cov=41%
---RLQLLDCTLRE---APIDNLMWGEMniHKMIHGLEMANVDIIECGFLKNadyikGSTSFQRVEDIIPFLKNKKkgktYVALVDYGRYDLKYLSEYDRRS-IDAIRVCFKKNE--------------IGLVLDYAAQIRAKGYQVCVQHVDTMGFFDEEIIDFIEKVNEFKPLAYSVVDTFGAMYEEDMLHYTGLADQYLSK--DILLGFHAHNNLMLADANAQSYINkMSAHRdvvVDASLFGCGRSAGNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q2LTN9(49-308:653) Pyruvate carboxylase carboxyltransferase subunit n=6 Tax=Deltaproteobacteria RepID=Q2LTN9_SYNAS  E=2e-15 s/c=0.33 id=18% cov=37%
------------------------PHTQLLVARERNEAGFFSIEITGGASIHVDMlrkqinplEKLEVLSANMPDTLFQTLCRGInmfgyRPYPENVIRLTVRSFARYVHI----WRVFDFLNHVSNMIPVFEEVRASGCLL-EPAICFSTGPE---HTDAYYVKKVGEILDVTGPDIlLAIKNHGGLGTPKRIGELVRSILNAYPDL---IIHYHGHNTDGADVGRIVEAVRNGAKIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
