Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	K	I	I	D	G	K	T	I	A	Q	Q	V	R	S	E	V	A	Q	K	V	Q	A	R	I	A	A	G	L	R	A	P	G	L	A	V	V	L	V	G	S	N	P	A	S	Q	I	Y	V	A	S	K	R	K	A	C	E	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	F	V	S	R	S	Y	D	L	P	E	T	T	S	E	A	E	L	L	E	L	I	D	T	L	N	A	D	N	T	I	D	G	I	L	V	Q	L	P	L	P	A	G	I	D	N	V	K	V	L	E	R	I	H	P	D	K	D	V
Secondary structure
SS confidence
Disorder																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	G	F	H	P	Y	N	V	G	R	L	C	Q	R	A	P	R	L	R	P	C	T	P	R	G	I	V	T	L	L	E	R	Y	N	I	D	T	F	G	L	N	A	V	V	I	G	A	S	N	I	V	G	R	P	M	S	M	E	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	A	G	C	T	T	T	V	T	H	R	F	T	K	N	L	R	H	H	V	E	N	A	D	L	L	I	V	A	V	G	K	P	G	F	I	P	G	D	W	I	K	E	G	A	I	V	I	D	V	G	I	N	R	L	E	N	G	K	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.
Sequence		V	G	D	V	V	F	E	D	A	A	K	R	A	S	Y	I	T	P	V	P	G	G	V	G	P	M	T	V	A	T	L	I	E	N	T	L	Q	A	C	V	E	Y	H	D	P	Q	D	E
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1b0a chain A Region: 2 - 288 Aligned: 287 Modelled: 287 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase,hydrolase Chain: A: PDB Molecule:protein (fold bifunctional protein); PDBTitle: 5,10, methylene-tetrahydropholate2 dehydrogenase/cyclohydrolase from e coli. Phyre2 PDB 4a5o chain B Region: 1 - 284 Aligned: 284 Modelled: 284 Confidence: 100.0% Identity: 67% PDB header:oxidoreductase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of pseudomonas aeruginosa n5, n10-2 methylenetetrahydrofolate dehydrogenase-cyclohydrolase (fold) Phyre2 PDB 2c2x chain B Region: 3 - 282 Aligned: 277 Modelled: 280 Confidence: 100.0% Identity: 43% PDB header:oxidoreductase Chain: B: PDB Molecule:methylenetetrahydrofolate dehydrogenase- PDBTitle: three dimensional structure of bifunctional2 methylenetetrahydrofolate dehydrogenase-cyclohydrolase3 from mycobacterium tuberculosis Phyre2 PDB 3l07 chain B Region: 2 - 284 Aligned: 282 Modelled: 283 Confidence: 100.0% Identity: 53% PDB header:oxidoreductase,hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate2 cyclohydrolase, putative bifunctional protein fold from francisella3 tularensis. Phyre2 PDB 1a4i chain B Region: 3 - 282 Aligned: 280 Modelled: 280 Confidence: 100.0% Identity: 44% PDB header:oxidoreductase Chain: B: PDB Molecule:methylenetetrahydrofolate dehydrogenase / PDBTitle: human tetrahydrofolate dehydrogenase / cyclohydrolase Phyre2 PDB 3p2o chain B Region: 2 - 282 Aligned: 280 Modelled: 281 Confidence: 100.0% Identity: 53% PDB header:oxidoreductase, hydrolase Chain: B: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni Phyre2 PDB 3p2o chain A Region: 2 - 282 Aligned: 280 Modelled: 279 Confidence: 100.0% Identity: 53% PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of fold bifunctional protein from campylobacter2 jejuni Phyre2 PDB 3ngl chain A Region: 4 - 284 Aligned: 273 Modelled: 281 Confidence: 100.0% Identity: 35% PDB header:oxidoreductase, hydrolase Chain: A: PDB Molecule:bifunctional protein fold; PDBTitle: crystal structure of bifunctional 5,10-methylenetetrahydrofolate2 dehydrogenase / cyclohydrolase from thermoplasma acidophilum Phyre2 PDB 4a26 chain B Region: 3 - 283 Aligned: 281 Modelled: 281 Confidence: 100.0% Identity: 47% PDB header:oxidoreductase Chain: B: PDB Molecule:putative c-1-tetrahydrofolate synthase, cytoplasmic; PDBTitle: the crystal structure of leishmania major n5,n10-2 methylenetetrahydrofolate dehydrogenase/cyclohydrolase Phyre2 PDB 1edz chain A Region: 2 - 282 Aligned: 266 Modelled: 269 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:5,10-methylenetetrahydrofolate dehydrogenase; PDBTitle: structure of the nad-dependent 5,10-2 methylenetetrahydrofolate dehydrogenase from saccharomyces3 cerevisiae Phyre2 PDB 1b0a chain A domain 1 Region: 123 - 288 Aligned: 166 Modelled: 166 Confidence: 100.0% Identity: 100% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 1a4i chain A domain 1 Region: 123 - 282 Aligned: 156 Modelled: 160 Confidence: 100.0% Identity: 47% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 1edz chain A domain 1 Region: 140 - 286 Aligned: 144 Modelled: 147 Confidence: 100.0% Identity: 31% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 1edz chain A domain 2 Region: 2 - 147 Aligned: 143 Modelled: 143 Confidence: 100.0% Identity: 22% Fold: Aminoacid dehydrogenase-like, N-terminal domain Superfamily: Aminoacid dehydrogenase-like, N-terminal domain Family: Tetrahydrofolate dehydrogenase/cyclohydrolase Phyre2 PDB 1b0a chain A domain 2 Region: 2 - 122 Aligned: 121 Modelled: 121 Confidence: 100.0% Identity: 100% Fold: Aminoacid dehydrogenase-like, N-terminal domain Superfamily: Aminoacid dehydrogenase-like, N-terminal domain Family: Tetrahydrofolate dehydrogenase/cyclohydrolase Phyre2 PDB 1a4i chain A domain 2 Region: 3 - 122 Aligned: 120 Modelled: 120 Confidence: 100.0% Identity: 40% Fold: Aminoacid dehydrogenase-like, N-terminal domain Superfamily: Aminoacid dehydrogenase-like, N-terminal domain Family: Tetrahydrofolate dehydrogenase/cyclohydrolase Phyre2 PDB 3d4o chain A Region: 35 - 282 Aligned: 234 Modelled: 244 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution Phyre2 PDB 2rir chain A Region: 30 - 282 Aligned: 239 Modelled: 253 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase, a chain; PDBTitle: crystal structure of dipicolinate synthase, a chain, from bacillus2 subtilis Phyre2 PDB 1v8b chain A Region: 40 - 236 Aligned: 196 Modelled: 197 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of a hydrolase Phyre2 PDB 3one chain A Region: 40 - 237 Aligned: 197 Modelled: 197 Confidence: 99.6% Identity: 20% PDB header:hydrolase/hydrolase substrate Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of lupinus luteus s-adenosyl-l-homocysteine2 hydrolase in complex with adenine Phyre2 1 c1b0aA_ 2 c4a5oB_ 3 c2c2xB_ 4 c3l07B_ 5 c1a4iB_ 6 c3p2oB_ 7 c3p2oA_ 8 c3nglA_ 9 c4a26B_ 10 c1edzA_ 11 d1b0aa1 12 d1a4ia1 13 d1edza1 14 d1edza2 15 d1b0aa2 16 d1a4ia2 17 c3d4oA_ 18 c2rirA_ 19 c1v8bA_ 20 c3oneA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499