PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3nglA_

Fold library id	PDB Header	Molecule	Title
c3nglA_	PDB header: oxidoreductase, hydrolase	Chain: A: PDB Molecule: bifunctional protein fold;	PDBTitle: crystal structure of bifunctional 5,10-methylenetetrahydrofolate2 dehydrogenase / cyclohydrolase from thermoplasma acidophilum

Links to external resources
Added to library: Sat Apr 23 08:55:16 2011

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence K I L R G E E I A E K K A E N L H G I I E R S G L E P S L K L I Q I G D N E A A S I Y A R A K I R R G K K I G I A V D L E K Y D D I S M K D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
S T T T
S
T
S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence L L K R I D D L A K D P Q I N G I M I E N P L P K G F D Y Y E I V R N I P Y Y K D V D A L S P Y N Q G L I A L N R E F L V P A T P R A V I D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S
T T
G G G S
G G G B T T
S T T
S S

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence I M D Y Y G Y H E N T V T I V N R S P V V G R P L S M M L L N R N Y T V S V C H S K T K D I G S M T R S S K I V V V A V G R P G F L N R E M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S
T T T T T
T T
T T S S
T T
B
G G G

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . .

Sequence V T P G S V V I D V G I N Y V N D K V V G D A N F E D L S E Y V E A I T P V P G G V G P I T A T N I L E N V V K A A E F Q K N N L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S S
S B
T T S S
T T T S S T T T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

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Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	K	I	L	R	G	E	E	I	A	E	K	K	A	E	N	L	H	G	I	I	E	R	S	G	L	E	P	S	L	K	L	I	Q	I	G	D	N	E	A	A	S	I	Y	A	R	A	K	I	R	R	G	K	K	I	G	I	A	V	D	L	E	K	Y	D	D	I	S	M	K	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		B			S																	T	T	T											S																				T									S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	L	L	K	R	I	D	D	L	A	K	D	P	Q	I	N	G	I	M	I	E	N	P	L	P	K	G	F	D	Y	Y	E	I	V	R	N	I	P	Y	Y	K	D	V	D	A	L	S	P	Y	N	Q	G	L	I	A	L	N	R	E	F	L	V	P	A	T	P	R	A	V	I	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T								S				T	T							G	G	G	S		G	G	G	B	T	T			S									T	T			S	S
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	I	M	D	Y	Y	G	Y	H	E	N	T	V	T	I	V	N	R	S	P	V	V	G	R	P	L	S	M	M	L	L	N	R	N	Y	T	V	S	V	C	H	S	K	T	K	D	I	G	S	M	T	R	S	S	K	I	V	V	V	A	V	G	R	P	G	F	L	N	R	E	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T			S										T	T	T											T	T								T	T		T	T								S	S									T	T		B		G	G	G
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.
Sequence	V	T	P	G	S	V	V	I	D	V	G	I	N	Y	V	N	D	K	V	V	G	D	A	N	F	E	D	L	S	E	Y	V	E	A	I	T	P	V	P	G	G	V	G	P	I	T	A	T	N	I	L	E	N	V	V	K	A	A	E	F	Q	K	N	N	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T											S	S	S					S	B							T	T	S	S					T	T	T	S	S	T	T	T