Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP0AC13
DateThu Jan 5 11:16:53 GMT 2012
Unique Job ID929ec98e9bc1fad1

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1ajza_
Top template information
Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
Confidence and coverage
Confidence:100.0% Coverage:100%
282 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGE
Secondary structure 
SS confidence 
Disorder  ???????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  STRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSL
Secondary structure 
SS confidence 
Disorder 
?
?????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  SEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKE
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  KLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSL
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........250.........260.........270.........280..
Sequence  ACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE
Secondary structure 
SS confidence 
Disorder 
???????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1ajz chain A

3D model

Region: 1 - 282
Aligned: 282
Modelled: 282
Confidence: 100.0%
Identity: 100%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Dihydropteroate synthetase

Phyre2

PDB 2bmb chain A

3D model

Region: 1 - 277
Aligned: 277
Modelled: 277
Confidence: 100.0%
Identity: 34%
PDB header:transferase
Chain: A: PDB Molecule:folic acid synthesis protein fol1;
PDBTitle: x-ray structure of the bifunctional 6-hydroxymethyl-7,8-2 dihydroxypterin pyrophosphokinase dihydropteroate synthase3 from saccharomyces cerevisiae

Phyre2

PDB 3tr9 chain A

3D model

Region: 4 - 276
Aligned: 269
Modelled: 273
Confidence: 100.0%
Identity: 43%
PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: structure of a dihydropteroate synthase (folp) in complex with pteroic2 acid from coxiella burnetii

Phyre2

PDB 1ad1 chain A

3D model

Region: 13 - 279
Aligned: 259
Modelled: 267
Confidence: 100.0%
Identity: 37%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Dihydropteroate synthetase

Phyre2

PDB 1tx2 chain A

3D model

Region: 1 - 275
Aligned: 264
Modelled: 275
Confidence: 100.0%
Identity: 41%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Dihydropteroate synthetase

Phyre2

PDB 1tx2 chain A

3D model

Region: 1 - 275
Aligned: 264
Modelled: 275
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:dhps, dihydropteroate synthase;
PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis

Phyre2

PDB 1eye chain A

3D model

Region: 14 - 276
Aligned: 248
Modelled: 249
Confidence: 100.0%
Identity: 42%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Dihydropteroate synthetase

Phyre2

PDB 2y5s chain A

3D model

Region: 3 - 279
Aligned: 266
Modelled: 277
Confidence: 100.0%
Identity: 45%
PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: crystal structure of burkholderia cenocepacia dihydropteroate2 synthase complexed with 7,8-dihydropteroate.

Phyre2

PDB 2vef chain B

3D model

Region: 11 - 275
Aligned: 247
Modelled: 253
Confidence: 100.0%
Identity: 35%
PDB header:transferase
Chain: B: PDB Molecule:dihydropteroate synthase;
PDBTitle: dihydropteroate synthase from streptococcus pneumoniae

Phyre2

PDB 2dza chain A

3D model

Region: 3 - 274
Aligned: 240
Modelled: 241
Confidence: 100.0%
Identity: 44%
PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: crystal structure of dihydropteroate synthase from thermus2 thermophilus hb8 in complex with 4-aminobenzoate

Phyre2

PDB 3mcn chain A

3D model

Region: 12 - 259
Aligned: 198
Modelled: 204
Confidence: 100.0%
Identity: 31%
PDB header:transferase
Chain: A: PDB Molecule:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
PDBTitle: crystal structure of the 6-hyroxymethyl-7,8-dihydropterin2 pyrophosphokinase dihydropteroate synthase bifunctional enzyme from3 francisella tularensis

Phyre2

PDB 2vp8 chain A

3D model

Region: 6 - 279
Aligned: 226
Modelled: 248
Confidence: 100.0%
Identity: 33%
PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase 2;
PDBTitle: structure of mycobacterium tuberculosis rv1207

Phyre2

PDB 2yci chain X

3D model

Region: 13 - 280
Aligned: 242
Modelled: 260
Confidence: 100.0%
Identity: 21%
PDB header:transferase
Chain: X: PDB Molecule:5-methyltetrahydrofolate corrinoid/iron sulfur protein
PDBTitle: methyltransferase native

Phyre2

PDB 1f6y chain A

3D model

Region: 16 - 280
Aligned: 237
Modelled: 261
Confidence: 100.0%
Identity: 18%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Methyltetrahydrofolate-utiluzing methyltransferases

Phyre2

PDB 3bof chain A domain 1

3D model

Region: 8 - 277
Aligned: 245
Modelled: 252
Confidence: 100.0%
Identity: 17%
Fold: TIM beta/alpha-barrel
Superfamily: Dihydropteroate synthetase-like
Family: Methyltetrahydrofolate-utiluzing methyltransferases

Phyre2

PDB 2h9a chain B

3D model

Region: 12 - 273
Aligned: 240
Modelled: 244
Confidence: 100.0%
Identity: 15%
PDB header:oxidoreductase
Chain: B: PDB Molecule:co dehydrogenase/acetyl-coa synthase, iron-
PDBTitle: corrinoid iron-sulfur protein

Phyre2

PDB 3bol chain B

3D model

Region: 8 - 277
Aligned: 242
Modelled: 260
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine
PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+

Phyre2

PDB 3k13 chain A

3D model

Region: 14 - 277
Aligned: 242
Modelled: 257
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:5-methyltetrahydrofolate-homocysteine methyltransferase;
PDBTitle: structure of the pterin-binding domain metr of 5-2 methyltetrahydrofolate-homocysteine methyltransferase from3 bacteroides thetaiotaomicron

Phyre2

PDB 2h9a chain A

3D model

Region: 3 - 279
Aligned: 229
Modelled: 235
Confidence: 99.8%
Identity: 14%
PDB header:oxidoreductase
Chain: A: PDB Molecule:carbon monoxide dehydrogenase corrinoid/iron-
PDBTitle: corrinoid iron-sulfur protein

Phyre2

PDB 3noy chain A

3D model

Region: 2 - 281
Aligned: 242
Modelled: 270
Confidence: 99.1%
Identity: 17%
PDB header:oxidoreductase
Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase;
PDBTitle: crystal structure of ispg (gcpe)

Phyre2
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d1ajza_
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c2bmbA_
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c3tr9A_
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d1ad1a_
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d1tx2a_
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c1tx2A_
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d1eyea_
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c2y5sA_
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c2vefB_
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c2dzaA_
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c3mcnA_
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c2vp8A_
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c2yciX_
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d1f6ya_
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d3bofa1
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c2h9aB_
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c3bolB_
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c3k13A_
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c2h9aA_
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c3noyA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1ajza_
100.0 100 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
2c2bmbA_
100.0 34 PDB header:transferase
Chain: A: PDB Molecule:folic acid synthesis protein fol1;
PDBTitle: x-ray structure of the bifunctional 6-hydroxymethyl-7,8-2 dihydroxypterin pyrophosphokinase dihydropteroate synthase3 from saccharomyces cerevisiae
3c3tr9A_
100.0 43 PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: structure of a dihydropteroate synthase (folp) in complex with pteroic2 acid from coxiella burnetii
4d1ad1a_
100.0 37 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
5d1tx2a_
100.0 41 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
6c1tx2A_
100.0 41 PDB header:transferase
Chain: A: PDB Molecule:dhps, dihydropteroate synthase;
PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis
7d1eyea_
100.0 42 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
8c2y5sA_
100.0 45 PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: crystal structure of burkholderia cenocepacia dihydropteroate2 synthase complexed with 7,8-dihydropteroate.
9c2vefB_
100.0 35 PDB header:transferase
Chain: B: PDB Molecule:dihydropteroate synthase;
PDBTitle: dihydropteroate synthase from streptococcus pneumoniae
10c2dzaA_
100.0 44 PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: crystal structure of dihydropteroate synthase from thermus2 thermophilus hb8 in complex with 4-aminobenzoate
11c3mcnA_
100.0 31 PDB header:transferase
Chain: A: PDB Molecule:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
PDBTitle: crystal structure of the 6-hyroxymethyl-7,8-dihydropterin2 pyrophosphokinase dihydropteroate synthase bifunctional enzyme from3 francisella tularensis
12c2vp8A_
100.0 33 PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase 2;
PDBTitle: structure of mycobacterium tuberculosis rv1207
13c2yciX_
100.0 21 PDB header:transferase
Chain: X: PDB Molecule:5-methyltetrahydrofolate corrinoid/iron sulfur protein
PDBTitle: methyltransferase native
14d1f6ya_
100.0 18 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Methyltetrahydrofolate-utiluzing methyltransferases
15d3bofa1
100.0 17 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Methyltetrahydrofolate-utiluzing methyltransferases
16c2h9aB_
100.0 15 PDB header:oxidoreductase
Chain: B: PDB Molecule:co dehydrogenase/acetyl-coa synthase, iron-
PDBTitle: corrinoid iron-sulfur protein
17c3bolB_
100.0 19 PDB header:transferase
Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine
PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+
18c3k13A_
100.0 18 PDB header:transferase
Chain: A: PDB Molecule:5-methyltetrahydrofolate-homocysteine methyltransferase;
PDBTitle: structure of the pterin-binding domain metr of 5-2 methyltetrahydrofolate-homocysteine methyltransferase from3 bacteroides thetaiotaomicron
19c2h9aA_
99.8 14 PDB header:oxidoreductase
Chain: A: PDB Molecule:carbon monoxide dehydrogenase corrinoid/iron-
PDBTitle: corrinoid iron-sulfur protein
20c3noyA_
99.1 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase;
PDBTitle: crystal structure of ispg (gcpe)
21d1qopa_
not modelled 98.7 21 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
22c2y0fD_
not modelled 98.5 18 PDB header:oxidoreductase
Chain: D: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase;
PDBTitle: structure of gcpe (ispg) from thermus thermophilus hb27
23c2ekcA_
not modelled 98.4 16 PDB header:lyase
Chain: A: PDB Molecule:tryptophan synthase alpha chain;
PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5
24c3navB_
not modelled 98.4 22 PDB header:lyase
Chain: B: PDB Molecule:tryptophan synthase alpha chain;
PDBTitle: crystal structure of an alpha subunit of tryptophan synthase from2 vibrio cholerae o1 biovar el tor str. n16961
25c3thaB_
not modelled 98.3 15 PDB header:lyase
Chain: B: PDB Molecule:tryptophan synthase alpha chain;
PDBTitle: tryptophan synthase subunit alpha from campylobacter jejuni.
26d1rd5a_
not modelled 98.1 17 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
27c3t4cD_
not modelled 97.9 17 PDB header:transferase
Chain: D: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase 1;
PDBTitle: crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from2 burkholderia ambifaria
28d1geqa_
not modelled 97.9 18 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
29c1rr2A_
not modelled 97.8 14 PDB header:transferase
Chain: A: PDB Molecule:transcarboxylase 5s subunit;
PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid
30c3bg3B_
not modelled 97.7 19 PDB header:ligase
Chain: B: PDB Molecule:pyruvate carboxylase, mitochondrial;
PDBTitle: crystal structure of human pyruvate carboxylase (missing2 the biotin carboxylase domain at the n-terminus)
31c3pg8B_
not modelled 97.6 20 PDB header:transferase
Chain: B: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase;
PDBTitle: truncated form of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase2 from thermotoga maritima
32c3sz8D_
not modelled 97.5 18 PDB header:transferase
Chain: D: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase 2;
PDBTitle: crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from2 burkholderia pseudomallei
33c3fs2A_
not modelled 97.5 17 PDB header:transferase
Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase;
PDBTitle: crystal structure of 2-dehydro-3-deoxyphosphooctonate2 aldolase from bruciella melitensis at 1.85a resolution
34d1xcfa_
not modelled 97.4 18 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
35c3js3C_
not modelled 97.4 20 PDB header:lyase
Chain: C: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: crystal structure of type i 3-dehydroquinate dehydratase (arod) from2 clostridium difficile with covalent reaction intermediate
36c2yr1B_
not modelled 97.3 14 PDB header:lyase
Chain: B: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: crystal structure of 3-dehydroquinate dehydratase from geobacillus2 kaustophilus hta426
37d1vr6a1
not modelled 97.3 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
38d1wbha1
not modelled 97.2 25 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
39c3stgA_
not modelled 97.2 19 PDB header:transferase
Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase;
PDBTitle: crystal structure of a58p, del(n59), and loop 7 truncated mutant of 3-2 deoxy-d-manno-octulosonate 8-phosphate synthase (kdo8ps) from3 neisseria meningitidis
40d1ujpa_
not modelled 97.2 19 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
41d1ps9a1
not modelled 97.1 17 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
42c1nvmG_
not modelled 97.1 15 PDB header:lyase/oxidoreductase
Chain: G: PDB Molecule:4-hydroxy-2-oxovalerate aldolase;
PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate
43d1mxsa_
not modelled 96.9 13 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
44d1nvma2
not modelled 96.8 18 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:HMGL-like
45c2c3zA_
not modelled 96.8 19 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus
46d1losc_
not modelled 96.7 19 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Decarboxylase
47c1ps9A_
not modelled 96.7 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:2,4-dienoyl-coa reductase;
PDBTitle: the crystal structure and reaction mechanism of e. coli 2,4-2 dienoyl coa reductase
48c3gr7A_
not modelled 96.7 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:nadph dehydrogenase;
PDBTitle: structure of oye from geobacillus kaustophilus, hexagonal2 crystal form
49c1zfjA_
not modelled 96.6 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase;
PDBTitle: inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) from2 streptococcus pyogenes
50d1d9ea_
not modelled 96.6 19 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
51d2a21a1
not modelled 96.4 17 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
52d1gqna_
not modelled 96.4 15 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
53c2nx9B_
not modelled 96.4 15 PDB header:lyase
Chain: B: PDB Molecule:oxaloacetate decarboxylase 2, subunit alpha;
PDBTitle: crystal structure of the carboxyltransferase domain of the2 oxaloacetate decarboxylase na+ pump from vibrio cholerae
54d1dvja_
not modelled 96.3 21 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Decarboxylase
55c3l2iB_
not modelled 96.3 17 PDB header:lyase
Chain: B: PDB Molecule:3-dehydroquinate dehydratase;
PDBTitle: 1.85 angstrom crystal structure of the 3-dehydroquinate dehydratase2 (arod) from salmonella typhimurium lt2.
56d1rqba2
not modelled 96.3 15 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:HMGL-like
57d1vhna_
not modelled 96.3 12 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
58d1z41a1
not modelled 96.2 17 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
59c3ajxA_
not modelled 96.2 19 PDB header:lyase
Chain: A: PDB Molecule:3-hexulose-6-phosphate synthase;
PDBTitle: crystal structure of 3-hexulose-6-phosphate synthase
60c2ftpA_
not modelled 96.2 21 PDB header:lyase
Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase;
PDBTitle: crystal structure of hydroxymethylglutaryl-coa lyase from pseudomonas2 aeruginosa
61c1djnB_
not modelled 96.2 19 PDB header:oxidoreductase
Chain: B: PDB Molecule:trimethylamine dehydrogenase;
PDBTitle: structural and biochemical characterization of recombinant wild type2 trimethylamine dehydrogenase from methylophilus methylotrophus (sp.3 w3a1)
62c3hf3A_
not modelled 96.2 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:chromate reductase;
PDBTitle: old yellow enzyme from thermus scotoductus sa-01
63d1vzwa1
not modelled 96.1 14 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
64c3nvtA_
not modelled 96.0 22 PDB header:transferase/isomerase
Chain: A: PDB Molecule:3-deoxy-d-arabino-heptulosonate 7-phosphate synthase;
PDBTitle: 1.95 angstrom crystal structure of a bifunctional 3-deoxy-7-2 phosphoheptulonate synthase/chorismate mutase (aroa) from listeria3 monocytogenes egd-e
65d1ka9f_
not modelled 96.0 19 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
66d1h5ya_
not modelled 96.0 16 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
67c3ivuB_
not modelled 96.0 16 PDB header:transferase
Chain: B: PDB Molecule:homocitrate synthase, mitochondrial;
PDBTitle: homocitrate synthase lys4 bound to 2-og
68c3bleA_
not modelled 95.8 17 PDB header:transferase
Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans;
PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate
69d1r3sa_
not modelled 95.8 14 Fold:TIM beta/alpha-barrel
Superfamily:UROD/MetE-like
Family:Uroporphyrinogen decarboxylase, UROD
70d1yxya1
not modelled 95.7 13 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:NanE-like
71d1vhca_
not modelled 95.7 14 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
72c3igsB_
not modelled 95.7 18 PDB header:isomerase
Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2;
PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase
73d1o60a_
not modelled 95.7 16 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
74c3bg5C_
not modelled 95.7 19 PDB header:ligase
Chain: C: PDB Molecule:pyruvate carboxylase;
PDBTitle: crystal structure of staphylococcus aureus pyruvate2 carboxylase
75c3lotC_
not modelled 95.6 15 PDB header:structure genomics, unknown function
Chain: C: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of protein of unknown function (np_070038.1) from2 archaeoglobus fulgidus at 1.89 a resolution
76c2h90A_
not modelled 95.5 15 PDB header:oxidoreductase
Chain: A: PDB Molecule:xenobiotic reductase a;
PDBTitle: xenobiotic reductase a in complex with coumarin
77c3k30B_
not modelled 95.4 18 PDB header:oxidoreductase
Chain: B: PDB Molecule:histamine dehydrogenase;
PDBTitle: histamine dehydrogenase from nocardiodes simplex
78d1j93a_
not modelled 95.4 11 Fold:TIM beta/alpha-barrel
Superfamily:UROD/MetE-like
Family:Uroporphyrinogen decarboxylase, UROD
79d1djqa1
not modelled 95.4 19 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
80d2czda1
not modelled 95.3 16 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Decarboxylase
81c3b0vD_
not modelled 95.3 16 PDB header:oxidoreductase/rna
Chain: D: PDB Molecule:trna-dihydrouridine synthase;
PDBTitle: trna-dihydrouridine synthase from thermus thermophilus in complex with2 trna
82c3no5C_
not modelled 95.2 16 PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a pfam duf849 domain containing protein2 (reut_a1631) from ralstonia eutropha jmp134 at 1.90 a resolution
83d1thfd_
not modelled 95.2 15 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
84c3q58A_
not modelled 95.2 19 PDB header:isomerase
Chain: A: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase;
PDBTitle: structure of n-acetylmannosamine-6-phosphate epimerase from salmonella2 enterica
85c3e49A_
not modelled 95.2 19 PDB header:metal binding protein
Chain: A: PDB Molecule:uncharacterized protein duf849 with a tim barrel fold;
PDBTitle: crystal structure of a prokaryotic domain of unknown function (duf849)2 with a tim barrel fold (bxe_c0966) from burkholderia xenovorans lb4003 at 1.75 a resolution
86c1jpkA_
not modelled 95.1 13 PDB header:lyase
Chain: A: PDB Molecule:uroporphyrinogen decarboxylase;
PDBTitle: gly156asp mutant of human urod, human uroporphyrinogen iii2 decarboxylase
87c3ru6C_
not modelled 95.0 17 PDB header:lyase
Chain: C: PDB Molecule:orotidine 5'-phosphate decarboxylase;
PDBTitle: 1.8 angstrom resolution crystal structure of orotidine 5'-phosphate2 decarboxylase (pyrf) from campylobacter jejuni subsp. jejuni nctc3 11168
88d1km4a_
not modelled 95.0 22 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Decarboxylase
89c1zcoA_
not modelled 94.9 17 PDB header:lyase
Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphoheptonate aldolase;
PDBTitle: crystal structure of pyrococcus furiosus 3-deoxy-d-arabino-2 heptulosonate 7-phosphate synthase
90c3chvA_
not modelled 94.9 13 PDB header:metal binding protein
Chain: A: PDB Molecule:prokaryotic domain of unknown function (duf849) with a tim
PDBTitle: crystal structure of a prokaryotic domain of unknown function (duf849)2 member (spoa0042) from silicibacter pomeroyi dss-3 at 1.45 a3 resolution
91c3f4wA_
not modelled 94.9 18 PDB header:synthase, lyase
Chain: A: PDB Molecule:putative hexulose 6 phosphate synthase;
PDBTitle: the 1.65a crystal structure of 3-hexulose-6-phosphate2 synthase from salmonella typhimurium
92c2infB_
not modelled 94.8 16 PDB header:lyase
Chain: B: PDB Molecule:uroporphyrinogen decarboxylase;
PDBTitle: crystal structure of uroporphyrinogen decarboxylase from2 bacillus subtilis
93c1vs1B_
not modelled 94.8 21 PDB header:transferase
Chain: B: PDB Molecule:3-deoxy-7-phosphoheptulonate synthase;
PDBTitle: crystal structure of 3-deoxy-d-arabino-heptulosonate-7-2 phosphate synthase (dahp synthase) from aeropyrum pernix3 in complex with mn2+ and pep
94c1ydoC_
not modelled 94.8 18 PDB header:lyase
Chain: C: PDB Molecule:hmg-coa lyase;
PDBTitle: crystal structure of the bacillis subtilis hmg-coa lyase, northeast2 structural genomics target sr181.
95c2o7qA_
not modelled 94.7 19 PDB header:oxidoreductase,transferase
Chain: A: PDB Molecule:bifunctional 3-dehydroquinate dehydratase/shikimate
PDBTitle: crystal structure of the a. thaliana dhq-dehydroshikimate-sdh-2 shikimate-nadp(h)
96d1q6oa_
not modelled 94.7 17 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Decarboxylase
97d1vyra_
not modelled 94.7 14 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
98c2cw6B_
not modelled 94.6 16 PDB header:lyase
Chain: B: PDB Molecule:hydroxymethylglutaryl-coa lyase, mitochondrial;
PDBTitle: crystal structure of human hmg-coa lyase: insights into2 catalysis and the molecular basis for3 hydroxymethylglutaric aciduria
99d1n8fa_
not modelled 94.5 15 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
100c3labA_
not modelled 94.5 19 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative kdpg (2-keto-3-deoxy-6-phosphogluconate)
PDBTitle: crystal structure of a putative kdpg (2-keto-3-deoxy-6-2 phosphogluconate) aldolase from oleispira antarctica
101c2ze3A_
not modelled 94.2 15 PDB header:isomerase
Chain: A: PDB Molecule:dfa0005;
PDBTitle: crystal structure of dfa0005 complexed with alpha-ketoglutarate: a2 novel member of the icl/pepm superfamily from alkali-tolerant3 deinococcus ficus
102c3rcyC_
not modelled 94.1 10 PDB header:isomerase
Chain: C: PDB Molecule:mandelate racemase/muconate lactonizing enzyme-like
PDBTitle: crystal structure of mandelate racemase/muconate lactonizing enzyme-2 like protein from roseovarius sp. tm1035
103c3e02A_
not modelled 94.0 18 PDB header:metal binding protein
Chain: A: PDB Molecule:uncharacterized protein duf849;
PDBTitle: crystal structure of a duf849 family protein (bxe_c0271) from2 burkholderia xenovorans lb400 at 1.90 a resolution
104c3qc3B_
not modelled 94.0 21 PDB header:isomerase
Chain: B: PDB Molecule:d-ribulose-5-phosphate-3-epimerase;
PDBTitle: crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699)2 from homo sapiens at 2.20 a resolution
105c2qf7A_
not modelled 94.0 20 PDB header:ligase
Chain: A: PDB Molecule:pyruvate carboxylase protein;
PDBTitle: crystal structure of a complete multifunctional pyruvate carboxylase2 from rhizobium etli
106d1pkla2
not modelled 93.8 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
107c3c6cA_
not modelled 93.8 11 PDB header:hydrolase
Chain: A: PDB Molecule:3-keto-5-aminohexanoate cleavage enzyme;
PDBTitle: crystal structure of a putative 3-keto-5-aminohexanoate cleavage2 enzyme (reut_c6226) from ralstonia eutropha jmp134 at 1.72 a3 resolution
108c3n4eA_
not modelled 93.6 16 PDB header:isomerase
Chain: A: PDB Molecule:mandelate racemase/muconate lactonizing enzyme, c-terminal
PDBTitle: crystal structure of mandelate racemase/muconate lactonizing protein2 from paracoccus denitrificans pd1222
109c2yw3E_
not modelled 93.5 13 PDB header:lyase
Chain: E: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-
PDBTitle: crystal structure analysis of the 4-hydroxy-2-oxoglutarate aldolase/2-2 deydro-3-deoxyphosphogluconate aldolase from tthb1
110c3jr2D_
not modelled 93.4 15 PDB header:biosynthetic protein
Chain: D: PDB Molecule:hexulose-6-phosphate synthase sgbh;
PDBTitle: x-ray crystal structure of the mg-bound 3-keto-l-gulonate-6-phosphate2 decarboxylase from vibrio cholerae o1 biovar el tor str. n16961
111c2y7eA_
not modelled 93.3 15 PDB header:lyase
Chain: A: PDB Molecule:3-keto-5-aminohexanoate cleavage enzyme;
PDBTitle: crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme2 (kce) from candidatus cloacamonas acidaminovorans (tetragonal form)
112d1wa3a1
not modelled 93.3 18 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
113c3cixA_
not modelled 93.2 18 PDB header:adomet binding protein
Chain: A: PDB Molecule:fefe-hydrogenase maturase;
PDBTitle: x-ray structure of the [fefe]-hydrogenase maturase hyde from2 thermotoga maritima in complex with thiocyanate
114c3hpxB_
not modelled 93.2 23 PDB header:transferase
Chain: B: PDB Molecule:2-isopropylmalate synthase;
PDBTitle: crystal structure of mycobacterium tuberculosis leua active site2 domain 1-425 (truncation mutant delta:426-644)
115c3kruC_
not modelled 93.1 23 PDB header:oxidoreductase
Chain: C: PDB Molecule:nadh:flavin oxidoreductase/nadh oxidase;
PDBTitle: crystal structure of the thermostable old yellow enzyme from2 thermoanaerobacter pseudethanolicus e39
116d1r30a_
not modelled 93.1 18 Fold:TIM beta/alpha-barrel
Superfamily:Radical SAM enzymes
Family:Biotin synthase
117c1r30A_
not modelled 93.1 18 PDB header:transferase
Chain: A: PDB Molecule:biotin synthase;
PDBTitle: the crystal structure of biotin synthase, an s-2 adenosylmethionine-dependent radical enzyme
118d1y0ea_
not modelled 92.9 11 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:NanE-like
119d1nu5a1
not modelled 92.9 14 Fold:TIM beta/alpha-barrel
Superfamily:Enolase C-terminal domain-like
Family:D-glucarate dehydratase-like
120d1a53a_
not modelled 92.8 21 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0