Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9XXE5
DateSat Apr 13 12:56:17 BST 2013
Unique Job IDa9c1dc10b9904a8a

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:66.656 Y:62.344 Z:47.898
Model (left) based on template c2fo0A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
Confidence and coverage
Confidence:100.0% Coverage: 92%
225 residues ( 92% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MASGTASMQRPSIEKEPYYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVMHC
Secondary structure 


































SS confidence 



























































Disorder  ?????????????





























???????








?
Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  VPPMEEEIKHYVIKTKGDKIFIEKVSFLSIPEMVEWHLTKKESVQKDVFLIKAISRQAWE
Secondary structure 


































SS confidence 



























































Disorder  ??????

































?????




?


??



Disorder confidence 



























































 
   .........130.........140.........150.........160.........170.........180
Sequence  LDHDNIEPLKKLGEGAFGEVMMGTMKFRKGGKSVQVAIKQAKLSNLTKEQIKEFMGEARV
Secondary structure 

















SS confidence 



























































Disorder 



























??











?
???












Disorder confidence 



























































 
   .........190.........200.........210.........220.........230.........240
Sequence  MRSLSHPHVVRFYGVPRRRVNVALCRSLNEFLAKCHRKLRCATPFFVCMSVNWLSVLNEL
Secondary structure 
















SS confidence 



























































Disorder 


































?????


















?
Disorder confidence 



























































 
   .....
Sequence  RVFLE
Secondary structure 




SS confidence 




Disorder  ?????
Disorder confidence 




 

Confidence Key
High(9)                    Low (0)
?Disordered ( 21%)
Alpha helix ( 27%)
Beta strand ( 28%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2fo0 chain A

3D model

Region: 4 - 243
Aligned: 225
Modelled: 239
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 1opl chain A

3D model

Region: 4 - 243
Aligned: 225
Modelled: 239
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2

PDB 1y57 chain A

3D model

Region: 4 - 242
Aligned: 227
Modelled: 239
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor

Phyre2

PDB 2h8h chain A

3D model

Region: 9 - 242
Aligned: 222
Modelled: 234
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor

Phyre2

PDB 1k9a chain B

3D model

Region: 1 - 243
Aligned: 225
Modelled: 243
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

PDB 2c0i chain A

3D model

Region: 9 - 243
Aligned: 223
Modelled: 235
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983

Phyre2

PDB 4fl2 chain A

3D model

Region: 14 - 243
Aligned: 218
Modelled: 230
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 2ozo chain A

3D model

Region: 9 - 243
Aligned: 224
Modelled: 234
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 3cbl chain A

3D model

Region: 10 - 242
Aligned: 201
Modelled: 208
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide

Phyre2

PDB 2j0k chain B

3D model

Region: 112 - 243
Aligned: 129
Modelled: 132
Confidence: 99.9%
Identity: 29%
PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.

Phyre2

PDB 4im2 chain A

3D model

Region: 126 - 243
Aligned: 109
Modelled: 118
Confidence: 99.9%
Identity: 24%
PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1;
PDBTitle: structure of tank-binding kinase 1

Phyre2

PDB 3g0e chain A

3D model

Region: 114 - 243
Aligned: 129
Modelled: 130
Confidence: 99.9%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:mast/stem cell growth factor receptor;
PDBTitle: kit kinase domain in complex with sunitinib

Phyre2

PDB 3pfq chain A

3D model

Region: 102 - 243
Aligned: 138
Modelled: 142
Confidence: 99.9%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii

Phyre2

PDB 2acx chain B

3D model

Region: 119 - 243
Aligned: 121
Modelled: 125
Confidence: 99.9%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp

Phyre2

PDB 3bu3 chain A domain 1

3D model

Region: 117 - 242
Aligned: 125
Modelled: 125
Confidence: 99.9%
Identity: 26%
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Family: Protein kinases, catalytic subunit

Phyre2

PDB 3lxk chain A

3D model

Region: 121 - 242
Aligned: 120
Modelled: 122
Confidence: 99.9%
Identity: 22%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak3;
PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6

Phyre2

PDB 3qa8 chain H

3D model

Region: 127 - 242
Aligned: 111
Modelled: 116
Confidence: 99.9%
Identity: 27%
PDB header:immune system, signaling protein
Chain: H: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta

Phyre2

PDB 2ivs chain A

3D model

Region: 117 - 242
Aligned: 125
Modelled: 126
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase receptor
PDBTitle: crystal structure of non-phosphorylated ret tyrosine kinase2 domain

Phyre2

PDB 3d4q chain A

3D model

Region: 117 - 242
Aligned: 119
Modelled: 126
Confidence: 99.9%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase;
PDBTitle: pyrazole-based inhibitors of b-raf kinase

Phyre2

PDB 4ebw chain A

3D model

Region: 115 - 242
Aligned: 124
Modelled: 127
Confidence: 99.9%
Identity: 29%
PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:focal adhesion kinase 1;
PDBTitle: structure of focal adhesion kinase catalytic domain in complex with2 novel allosteric inhibitor

Phyre2
1

c2fo0A_
2

c1oplA_
3

c1y57A_
4

c2h8hA_
5

c1k9aB_
6

c2c0iA_
7

c4fl2A_
8

c2ozoA_
9

c3cblA_
10

c2j0kB_
11

c4im2A_
12

c3g0eA_
13

c3pfqA_
14

c2acxB_
15

d3bu3a1
16

c3lxkA_
17

c3qa8H_
18

c2ivsA_
19

c3d4qA_
20

c4ebwA_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



50



51



52



53



54



55



56



57



58



59



60



61



62



63



64



65



66



67



68



69



70



71



72



73



74



75



76



77



78



79



80



81



82



83



84



85



86



87



88



89



90



91



92



93



94



95



96



97



98



99



100



101



102



103



104



105



106



107



108



109



110



111



112



113



114



115



116



117



118



119



120



121



122



123



124



125



126



127



128



129



130



131



132



133



134



135



136



137



138



139



140



141



142



143



144



145



146



147



148



149



150



151



152



153



154



155



156



157



158



159



160



161



162



163



164



165



166



167



168



169



170



171



172



173



174



175



176



177



178



179



180



181



182



183



184



185



186



187



188



189



190



191



192



193



194



195



196



197



198



199



200



201



202



203



204



205



206



207



208



209



210



211



212



213



214



215



216



217



218



219



220



221



222



223



224



225



226



227



228



229



230



231



232



233



234



235



236



237



238



239



240



241



242



243



244



245



246



247



248



249



250



251



252



253



254



255



256



257



258



259



260



261



262



263



264



265



266



267



268



269



270



271



272



273



274



275



276



277



278



279



280



281



282



283



284



285



286



287



288



289



290



291



292



293



294



295



296



297



298



299



300



301



302



303



304



305



306



307



308



309



310



311



312



313



314



315



316



317



318



319



320



321



322



323



324



325



326



327



328



329



330



331



332



333



334



335



336



337



338



339



340



341



342



343



344



345



346



347



348



349



350



351



352



353



354



355



356



357



358



359



360



361



362



363



364



365



366



367



368



369



370



371



372



373



374



375



376



377



378



379



380



381



382



383



384



385



386



387



388



389



390



391



392



393



394



395



396



397



398



399



400



401



402



403



404



405



406



407



408



409



410



411



412



413



414



415



416



417



418



419



420



421



422



423



424



425






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2fo0A_



100.0 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
2c1oplA_



100.0 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
3c1y57A_



100.0 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
4c2h8hA_



100.0 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
5c1k9aB_



100.0 26 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
6c2c0iA_



100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
7c4fl2A_



100.0 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
8c2ozoA_



100.0 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
9c3cblA_



100.0 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
10c2j0kB_



99.9 29 PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.
11c4im2A_



99.9 24 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1;
PDBTitle: structure of tank-binding kinase 1
12c3g0eA_



99.9 25 PDB header:transferase
Chain: A: PDB Molecule:mast/stem cell growth factor receptor;
PDBTitle: kit kinase domain in complex with sunitinib
13c3pfqA_



99.9 18 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
14c2acxB_



99.9 16 PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp
15d3bu3a1



99.9 26 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
16c3lxkA_



99.9 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak3;
PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6
17c3qa8H_



99.9 27 PDB header:immune system, signaling protein
Chain: H: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta
18c2ivsA_



99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase receptor
PDBTitle: crystal structure of non-phosphorylated ret tyrosine kinase2 domain
19c3d4qA_



99.9 23 PDB header:transferase
Chain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase;
PDBTitle: pyrazole-based inhibitors of b-raf kinase
20c4ebwA_



99.9 29 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:focal adhesion kinase 1;
PDBTitle: structure of focal adhesion kinase catalytic domain in complex with2 novel allosteric inhibitor
21d1opja_



not modelled 99.9 28 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
22c2vwiC_



not modelled 99.9 23 PDB header:transferase
Chain: C: PDB Molecule:serine/threonine-protein kinase osr1;
PDBTitle: structure of the osr1 kinase, a hypertension drug target
23c3soaA_



not modelled 99.9 16 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit
PDBTitle: full-length human camkii
24c3zzwA_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2;
PDBTitle: crystal structure of the kinase domain of ror2
25c4aojA_



not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:high affinity nerve growth factor receptor;
PDBTitle: human trka in complex with the inhibitor az-23
26c3lxnA_



not modelled 99.9 18 PDB header:transferase
Chain: A: PDB Molecule:non-receptor tyrosine-protein kinase tyk2;
PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6
27c3tkuB_



not modelled 99.9 24 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:serine/threonine-protein kinase mrck beta;
PDBTitle: mrck beta in complex with fasudil
28c3fupB_



not modelled 99.9 23 PDB header:transferase
Chain: B: PDB Molecule:tyrosine-protein kinase jak2;
PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes
29d1qcfa3



not modelled 99.9 28 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
30c1ym7C_



not modelled 99.9 15 PDB header:transferase
Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1;
PDBTitle: g protein-coupled receptor kinase 2 (grk2)
31c3vw6B_



not modelled 99.9 22 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:mitogen-activated protein kinase kinase kinase 5;
PDBTitle: crystal structure of human apoptosis signal-regulating kinase 1 (ask1)2 with imidazopyridine inhibitor
32c3eygA_



not modelled 99.9 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase;
PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes
33d1lufa_



not modelled 99.9 24 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
34c1lufA_



not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:muscle-specific tyrosine kinase receptor musk;
PDBTitle: crystal structure of the musk tyrosine kinase: insights2 into receptor autoregulation
35c3cc6A_



not modelled 99.9 25 PDB header:transferase
Chain: A: PDB Molecule:protein tyrosine kinase 2 beta;
PDBTitle: crystal structure of kinase domain of protein tyrosine kinase 2 beta2 (ptk2b)
36c1koaA_



not modelled 99.9 22 PDB header:kinase
Chain: A: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains
37d1uwha_



not modelled 99.9 23 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
38c3qa8A_



not modelled 99.9 28 PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta
39c2pvfA_



not modelled 99.9 22 PDB header:transferase
Chain: A: PDB Molecule:fibroblast growth factor receptor 2;
PDBTitle: crystal structure of tyrosine phosphorylated activated fgf receptor 22 (fgfr2) kinase domain in complex with atp analog and substrate3 peptide
40d1u59a_



not modelled 99.9 28 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
41d2psqa1



not modelled 99.9 20 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
42c2psqA_



not modelled 99.9 20 PDB header:transferase
Chain: A: PDB Molecule:fibroblast growth factor receptor 2;
PDBTitle: crystal structure of unphosphorylated unactivated wild type2 fgf receptor 2 (fgfr2) kinase domain
43c2w1iB_



not modelled 99.9 22 PDB header:transferase
Chain: B: PDB Molecule:jak2;
PDBTitle: structure determination of aurora kinase in complex with2 inhibitor
44c3c4wB_



not modelled 99.9 19 PDB header:transferase
Chain: B: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of g protein coupled receptor kinase 1 bound to atp2 and magnesium chloride at 2.7a
45c1yvjA_



not modelled 99.9 20 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak3;
PDBTitle: crystal structure of the jak3 kinase domain in complex with2 a staurosporine analogue
46d1qpca_



not modelled 99.9 25 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
47d1mp8a_



not modelled 99.9 29 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
48c3q5iA_



not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:protein kinase;
PDBTitle: crystal structure of pbanka_031420
49c2c30A_



not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6;
PDBTitle: crystal structure of the human p21-activated kinase 6
50c3c4yA_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a
51c4e1zA_



not modelled 99.9 18 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:non-receptor tyrosine-protein kinase tyk2;
PDBTitle: structure of mouse tyk-2 complexed to a 3-aminoindazole inhibitor
52d1s9ja_



not modelled 99.9 25 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
53d2jfla1



not modelled 99.9 24 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
54d1xkka_



not modelled 99.9 26 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
55c1xkkA_



not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:epidermal growth factor receptor;
PDBTitle: egfr kinase domain complexed with a quinazoline inhibitor-2 gw572016
56c2jamB_



not modelled 99.9 19 PDB header:transferase
Chain: B: PDB Molecule:calcium/calmodulin-dependent protein kinase type
PDBTitle: crystal structure of human calmodulin-dependent protein2 kinase i g
57c2qobA_



not modelled 99.9 32 PDB header:transferase
Chain: A: PDB Molecule:ephrin receptor;
PDBTitle: human epha3 kinase domain, base structure
58d1jpaa_



not modelled 99.9 28 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
59c3nyoB_



not modelled 99.8 15 PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein-coupled receptor kinase 6 in complex2 with amp
60c3l9pA_



not modelled 99.8 23 PDB header:transferase
Chain: A: PDB Molecule:anaplastic lymphoma kinase;
PDBTitle: crystal structure of the anaplastic lymphoma kinase catalytic domain
61c2j51A_



not modelled 99.8 24 PDB header:transferase
Chain: A: PDB Molecule:ste20-like serine/threonine-protein kinase;
PDBTitle: crystal structure of human ste20-like kinase bound to 5-2 amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6-3 difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide
62c2r5tA_



not modelled 99.8 21 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase sgk1;
PDBTitle: crystal structure of inactive serum and glucocorticoid-2 regulated kinase 1 in complex with amp-pnp
63c3kulB_



not modelled 99.8 27 PDB header:transferase
Chain: B: PDB Molecule:ephrin type-a receptor 8;
PDBTitle: kinase domain of human ephrin type-a receptor 8 (epha8)
64c3hztA_



not modelled 99.8 24 PDB header:transferase
Chain: A: PDB Molecule:calcium-dependent protein kinase 3;
PDBTitle: crystal structure of toxoplasma gondii cdpk3, tgme49_105860
65d2j4za1



not modelled 99.8 25 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
66d1fvra_



not modelled 99.8 30 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
67c3dpkA_



not modelled 99.8 27 PDB header:transferase
Chain: A: PDB Molecule:macrophage colony-stimulating factor 1 receptor;
PDBTitle: cfms tyrosine kinase in complex with a pyridopyrimidinone2 inhibitor
68c2bdwB_



not modelled 99.8 22 PDB header:transferase
Chain: B: PDB Molecule:hypothetical protein k11e8.1d;
PDBTitle: crystal structure of the auto-inhibited kinase domain of2 calcium/calmodulin activated kinase ii
69c2clqA_



not modelled 99.8 19 PDB header:transferase
Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 5;
PDBTitle: structure of mitogen-activated protein kinase kinase kinase2 5
70c3p23B_



not modelled 99.8 25 PDB header:hydrolase, transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1;
PDBTitle: crystal structure of the human kinase and rnase domains in complex2 with adp
71d1sm2a_



not modelled 99.8 28 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
72d1p4oa_



not modelled 99.8 23 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
73c3rp9A_



not modelled 99.8 15 PDB header:transferase
Chain: A: PDB Molecule:mitogen-activated protein kinase;
PDBTitle: crystal structure of the apo mapk from toxoplasma gondii, 25.m01780 or2 tgme49_007820
74d1fmka3



not modelled 99.8 28 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
75c4eutA_



not modelled 99.8 23 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1;
PDBTitle: structure of bx-795 complexed with unphosphorylated human tbk1 kinase-2 uld domain
76d1mqba_



not modelled 99.8 27 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
77c2a27B_



not modelled 99.8 23 PDB header:transferase
Chain: B: PDB Molecule:death-associated protein kinase 2;
PDBTitle: human drp-1 kinase, w305s s308a d40 mutant, crystal form with 82 monomers in the asymmetric unit
78d1phka_



not modelled 99.8 20 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
79d1koba_



not modelled 99.8 19 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
80d1ob3a_



not modelled 99.8 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
81c4dn5A_



not modelled 99.8 20 PDB header:transferase
Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 14;
PDBTitle: crystal structure of nf-kb-inducing kinase (nik)
82d1k2pa_



not modelled 99.8 29 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
83d1fgka_



not modelled 99.8 19 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
84c3p1aA_



not modelled 99.8 17 PDB header:transferase
Chain: A: PDB Molecule:membrane-associated tyrosine- and threonine-specific cdc2-
PDBTitle: structure of human membrane-associated tyrosine- and threonine-2 specific cdc2-inhibitory kinase myt1 (pkmyt1)
85d1t46a_



not modelled 99.8 25 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
86c3d9vA_



not modelled 99.8 19 PDB header:transferase
Chain: A: PDB Molecule:rho-associated protein kinase 1;
PDBTitle: crystal structure of rock i bound to h-1152p a di-2 methylated variant of fasudil
87c3dfaA_



not modelled 99.8 15 PDB header:transferase
Chain: A: PDB Molecule:calcium-dependent protein kinase cgd3_920;
PDBTitle: crystal structure of kinase domain of calcium-dependent protein kinase2 cgd3_920 from cryptosporidium parvum
88c2vd5A_



not modelled 99.8 23 PDB header:transferase
Chain: A: PDB Molecule:dmpk protein;
PDBTitle: structure of human myotonic dystrophy protein kinase in2 complex with the bisindoylmaleide inhibitor bim viii
89c4fijA_



not modelled 99.8 23 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase pak 4;
PDBTitle: catalytic domain of human pak4
90c4fieB_



not modelled 99.8 22 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase pak 4;
PDBTitle: full-length human pak4
91c3ku2A_



not modelled 99.8 17 PDB header:transferase
Chain: A: PDB Molecule:calmodulin-domain protein kinase 1;
PDBTitle: crystal structure of inactivated form of cdpk1 from toxoplasma gondii,2 tgme49.101440
92c4apcA_



not modelled 99.8 14 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase nek1;
PDBTitle: crystal structure of human nima-related kinase 1 (nek1)
93c3lvpD_



not modelled 99.8 28 PDB header:transferase
Chain: D: PDB Molecule:insulin-like growth factor 1 receptor;
PDBTitle: crystal structure of bisphosphorylated igf1-r kinase domain (2p) in2 complex with a bis-azaindole inhibitor
94c3hkoA_



not modelled 99.8 22 PDB header:transferase
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase with a kinase
PDBTitle: crystal structure of a cdpk kinase domain from cryptosporidium parvum,2 cgd7_40
95c2bmcD_



not modelled 99.8 26 PDB header:transferase
Chain: D: PDB Molecule:serine threonine-protein kinase 6;
PDBTitle: aurora-2 t287d t288d complexed with pha-680632
96d1jksa_



not modelled 99.8 23 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
97c3ckxA_



not modelled 99.8 23 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 24;
PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine
98d1uu3a_



not modelled 99.8 22 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
99c2qg5D_



not modelled 99.8 23 PDB header:transferase
Chain: D: PDB Molecule:calcium/calmodulin-dependent protein kinase;
PDBTitle: cryptosporidium parvum calcium dependent protein kinase cgd7_1840
100c3eqiA_



not modelled 99.8 25 PDB header:transferase
Chain: A: PDB Molecule:dual specificity mitogen-activated protein kinase kinase 1;
PDBTitle: x-ray structure of the human mitogen-activated protein kinase kinase 12 (mek1) in a binary complex with adp and mg2p
101c3k54A_



not modelled 99.8 32 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: structures of human bruton's tyrosine kinase in active and inactive2 conformations suggests a mechanism of activation for tec family3 kinases.
102d1u5ra_



not modelled 99.8 19 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
103d1yhwa1



not modelled 99.8 19 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
104c4dc2A_



not modelled 99.8 16 PDB header:transferase/transferase substrate
Chain: A: PDB Molecule:protein kinase c iota type;
PDBTitle: structure of pkc in complex with a substrate peptide from par-3
105c2ya9A_



not modelled 99.8 22 PDB header:transferase
Chain: A: PDB Molecule:death-associated protein kinase 2;
PDBTitle: crystal structure of the autoinhibited form of mouse dapk2
106d1o6la_



not modelled 99.8 21 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
107d1xbba_



not modelled 99.8 27 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
108c1u5qA_



not modelled 99.8 19 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine protein kinase tao2;
PDBTitle: crystal structure of the tao2 kinase domain: activation and2 specifity of a ste20p map3k
109d1o6ya_



not modelled 99.8 17 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
110c1kobB_



not modelled 99.8 19 PDB header:kinase
Chain: B: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (aplysia), autoregulated protein2 kinase domain
111c4fvrA_



not modelled 99.8 20 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak2;
PDBTitle: crystal structure of the jak2 pseudokinase domain mutant v617f (mg-2 atp-bound form)
112c2qofA_



not modelled 99.8 32 PDB header:transferase
Chain: A: PDB Molecule:ephrin receptor;
PDBTitle: human epha3 kinase and juxtamembrane region, y596f mutant
113c2x4fA_



not modelled 99.8 14 PDB header:transferase
Chain: A: PDB Molecule:myosin light chain kinase family member 4;
PDBTitle: the crystal structure of the human myosin light chain2 kinase loc340156.
114c1mruB_



not modelled 99.8 17 PDB header:transferase
Chain: B: PDB Molecule:probable serine/threonine-protein kinase pknb;
PDBTitle: intracellular ser/thr protein kinase domain of2 mycobacterium tuberculosis pknb.
115c3igoA_



not modelled 99.8 16 PDB header:transferase
Chain: A: PDB Molecule:calmodulin-domain protein kinase 1;
PDBTitle: crystal structure of cryptosporidium parvum cdpk1, cgd3_920
116d1tkia_



not modelled 99.8 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
117c3v5qB_



not modelled 99.8 24 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:nt-3 growth factor receptor;
PDBTitle: discovery of a selective trk inhibitor with efficacy in rodent cancer2 tumor models
118c3an0A_



not modelled 99.8 25 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:dual specificity mitogen-activated protein kinase kinase 6;
PDBTitle: crystal structure of non-phosphorylated map2k6 as a putative auto2 inhibition state
119d1xwsa_



not modelled 99.8 19 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
120c2vz6A_



not modelled 99.8 18 PDB header:transferase
Chain: A: PDB Molecule:calcium calmodulin dependent protein kinase type ii alpha
PDBTitle: structure of human calcium calmodulin dependent protein2 kinase type ii alpha (camk2a) in complex with indirubin3 e804

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite