PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3vw6B_

Fold library id	PDB Header	Molecule	Title
c3vw6B_	PDB header: transferase/transferase inhibitor	Chain: B: PDB Molecule: mitogen-activated protein kinase kinase kinase 5;	PDBTitle: crystal structure of human apoptosis signal-regulating kinase 1 (ask1)2 with imidazopyridine inhibitor

Links to external resources
Added to library: Sat Nov 3 17:34:10 2012

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence L E Y D Y E Y D E N G D R V V L G K G T Y G I V Y A G R D L S N Q V R I A I K E I P E Q P L H E E I A L H K H L K H K N I V Q Y L G S F S E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
B
T T S S B
S S S T T T
T T
T T B

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence N G F I K I F M E Q V P G G S L S A L L R S K W G P L K D N E Q T I G F Y T K Q I L E G L K Y L H D N Q I V H R D I K G D N V L I N T Y S G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T
B T T
T T
T T
S
S G G G
T T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence V L K I S D F G T S K R L T G T L Q Y M A P E I I D K G P R G Y G K A A D I W S L G C T I I E M A T G K P P F Y E L G E P Q A A M F K V G M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
G G G
G G G
S S S
T T G G G
S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . .

Sequence F K V H P E I P E S M S A E A K A F I L K C F E P D P D K R A C A N D L L V D E F L K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
T T S
T
S
T T T S
T S G G G

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	L	E	Y	D	Y	E	Y	D	E	N	G	D	R	V	V	L	G	K	G	T	Y	G	I	V	Y	A	G	R	D	L	S	N	Q	V	R	I	A	I	K	E	I	P	E	Q	P	L	H	E	E	I	A	L	H	K	H	L	K	H	K	N	I	V	Q	Y	L	G	S	F	S	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							B		T	T	S	S	B							S	S	S								T	T	T																						T	T				T	T	B
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	N	G	F	I	K	I	F	M	E	Q	V	P	G	G	S	L	S	A	L	L	R	S	K	W	G	P	L	K	D	N	E	Q	T	I	G	F	Y	T	K	Q	I	L	E	G	L	K	Y	L	H	D	N	Q	I	V	H	R	D	I	K	G	D	N	V	L	I	N	T	Y	S	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T										T	T		B								T	T				T	T																						T	T				S			S	G	G	G					T	T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	V	L	K	I	S	D	F	G	T	S	K	R	L	T	G	T	L	Q	Y	M	A	P	E	I	I	D	K	G	P	R	G	Y	G	K	A	A	D	I	W	S	L	G	C	T	I	I	E	M	A	T	G	K	P	P	F	Y	E	L	G	E	P	Q	A	A	M	F	K	V	G	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								S	S								G	G	G										G	G	G		S																		S	S		T	T	G	G	G		S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.
Sequence	F	K	V	H	P	E	I	P	E	S	M	S	A	E	A	K	A	F	I	L	K	C	F	E	P	D	P	D	K	R	A	C	A	N	D	L	L	V	D	E	F	L	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T							T	T	S												T		S		T	T	T	S								T	S	G	G	G