PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c3dpkA_

Fold library id	PDB Header	Molecule	Title
c3dpkA_	PDB header: transferase	Chain: A: PDB Molecule: macrophage colony-stimulating factor 1 receptor;	PDBTitle: cfms tyrosine kinase in complex with a pyridopyrimidinone2 inhibitor

Links to external resources
Added to library: Tue Mar 16 14:29:04 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence V R W K I I E S S Y T F I D P Y N E K W E F P R N N L Q F G K T L G A G A F G K V V E A T A F G L G A V L K V A V K M L K S T A H A D E K E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G B
G G G
S S S
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence A L M S E L K I M S H L G Q H E N I V N L L G A C T H G G P V L V I T E Y C C Y G D L L N F L R R Q L S S R D L L H F S S Q V A Q G M A F L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T B
S S S S
T T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence A S K N C I H R D V A A R N V L L T N G H V A K I G D F G L A R D I M N D S N Y I V R L P V K W M A P E S I F D C V Y T V Q S D V W S Y G I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
S G G G G G G
T T T S
G G G
T T S B
B
G G G S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . .

Sequence L L W E I F S L G L N P Y P G I L V N S K F Y K L V K D G Y Q M A Q P A F A P K N I Y S I M Q A C W A L E P T H R P T F Q Q I C S F L Q E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S
S S T T
S S T T
T T
T
S S G G G S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	V	R	W	K	I	I	E	S	S	Y	T	F	I	D	P	Y	N	E	K	W	E	F	P	R	N	N	L	Q	F	G	K	T	L	G	A	G	A	F	G	K	V	V	E	A	T	A	F	G	L	G	A	V	L	K	V	A	V	K	M	L	K	S	T	A	H	A	D	E	K	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																		G	G	G	B			G	G	G											S	S										S														T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	A	L	M	S	E	L	K	I	M	S	H	L	G	Q	H	E	N	I	V	N	L	L	G	A	C	T	H	G	G	P	V	L	V	I	T	E	Y	C	C	Y	G	D	L	L	N	F	L	R	R	Q	L	S	S	R	D	L	L	H	F	S	S	Q	V	A	Q	G	M	A	F	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																T	T	B									S	S	S	S									T	T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	A	S	K	N	C	I	H	R	D	V	A	A	R	N	V	L	L	T	N	G	H	V	A	K	I	G	D	F	G	L	A	R	D	I	M	N	D	S	N	Y	I	V	R	L	P	V	K	W	M	A	P	E	S	I	F	D	C	V	Y	T	V	Q	S	D	V	W	S	Y	G	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T				S			S	G	G	G					G	G	G								T	T	T	S		G	G	G		T	T	S	B			B		G	G	G	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.
Sequence	L	L	W	E	I	F	S	L	G	L	N	P	Y	P	G	I	L	V	N	S	K	F	Y	K	L	V	K	D	G	Y	Q	M	A	Q	P	A	F	A	P	K	N	I	Y	S	I	M	Q	A	C	W	A	L	E	P	T	H	R	P	T	F	Q	Q	I	C	S	F	L	Q	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	S			S	S	T	T			S	S									T	T							T	T													T		S	S	G	G	G	S