Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ965N4
DateFri May 3 21:39:00 BST 2013
Unique Job ID971f5ce47b1bdda5

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:70.633 Y:81.132 Z:47.110
Model (left) based on template c1xa6A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
Confidence and coverage
Confidence:100.0% Coverage: 92%
387 residues ( 92% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MEDDGPPGSSGASKGYWKQNLYLLQEKAPKPNAVLCRKPLQQRPRHFGAEFHGLIDRNEA
Secondary structure 
SS confidence 
Disorder  ????????????????
?
??????????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  EKMLLEAGEGSYLVRESNRSRDACTLCMIFDAKVMNYKLYYDGQFYVGEKRFDTMDLLVA
Secondary structure 
SS confidence 
Disorder 
?
???????
????????????
???
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  DGLISMFVDLHAADYIKRMADEAIYEDSPYSRYTNAAATTSDIVRRPVTRAHNFTSYTFK
Secondary structure 
SS confidence 
Disorder 
?
???
???????????????????????????????????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  APHYCDYCRNFLWGLVHQGMRCEDCGFAAHKKCSEKTLHDCVPDSKYVKRMFGVDITTLC
Secondary structure 
SS confidence 
Disorder  ?
?
?
??????????????????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  MAHGADLPPIVPLCIGEVESRGLDVEGIYRVSGSYDHMEKLKQQFDSNQYVDLATVCDIH
Secondary structure 
SS confidence 
Disorder 
?
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  TVCGLLKLYFRLLPQQLIPFSVHKQLLVAYQETNQRSTHERERQIRKVMMELSDANIITL
Secondary structure 
SS confidence 
Disorder 
??????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  GAVLAHLKKVADHSAKNKMTVENLATIFSPTLFCSGSIPAMPNHQLLHFLINNPRVVPKH
Secondary structure 
SS confidence 
Disorder 
????
????????
????
Disorder confidence 
 
   .
Sequence  H
Secondary structure 
SS confidence 
Disorder  ?
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 33%)
Alpha helix ( 49%)
Beta strand ( 6%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1xa6 chain A

3D model

Region: 16 - 418
Aligned: 387
Modelled: 403
Confidence: 100.0%
Identity: 40%
PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin

Phyre2

PDB 3iug chain A

3D model

Region: 228 - 418
Aligned: 180
Modelled: 191
Confidence: 100.0%
Identity: 32%
PDB header:splicing
Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics;
PDBTitle: crystal structure of the rhogap domain of rics

Phyre2

PDB 3byi chain A

3D model

Region: 229 - 418
Aligned: 187
Modelled: 190
Confidence: 100.0%
Identity: 30%
PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 15;
PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15)

Phyre2

PDB 3kuq chain A

3D model

Region: 229 - 412
Aligned: 181
Modelled: 184
Confidence: 100.0%
Identity: 27%
PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 7;
PDBTitle: crystal structure of the dlc1 rhogap domain

Phyre2

PDB 2ee5 chain A

3D model

Region: 222 - 420
Aligned: 195
Modelled: 199
Confidence: 100.0%
Identity: 28%
PDB header:hydrolase
Chain: A: PDB Molecule:rho gtpase activating protein 5 variant;
PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant

Phyre2

PDB 1tx4 chain A

3D model

Region: 228 - 418
Aligned: 187
Modelled: 191
Confidence: 100.0%
Identity: 24%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 2ngr chain B

3D model

Region: 228 - 418
Aligned: 187
Modelled: 191
Confidence: 100.0%
Identity: 23%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (gtpase activating protein (rhg));
PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap.

Phyre2

PDB 1xa6 chain A domain 1

3D model

Region: 230 - 418
Aligned: 186
Modelled: 189
Confidence: 100.0%
Identity: 36%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 3fk2 chain B

3D model

Region: 229 - 417
Aligned: 185
Modelled: 189
Confidence: 100.0%
Identity: 30%
PDB header:signaling protein, hydrolase activator
Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1;
PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1

Phyre2

PDB 3qis chain A

3D model

Region: 229 - 411
Aligned: 172
Modelled: 183
Confidence: 100.0%
Identity: 17%
PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl

Phyre2

PDB 3msx chain B

3D model

Region: 229 - 418
Aligned: 184
Modelled: 190
Confidence: 100.0%
Identity: 23%
PDB header:protein binding
Chain: B: PDB Molecule:rho gtpase-activating protein 20;
PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20

Phyre2

PDB 1xa6 chain A domain 2

3D model

Region: 16 - 155
Aligned: 139
Modelled: 140
Confidence: 100.0%
Identity: 41%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2ovj chain A

3D model

Region: 235 - 417
Aligned: 179
Modelled: 183
Confidence: 100.0%
Identity: 32%
PDB header:signaling protein
Chain: A: PDB Molecule:rac gtpase-activating protein 1;
PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap.

Phyre2

PDB 2qv2 chain A

3D model

Region: 229 - 413
Aligned: 174
Modelled: 185
Confidence: 100.0%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway

Phyre2

PDB 1f7c chain A

3D model

Region: 248 - 419
Aligned: 168
Modelled: 172
Confidence: 100.0%
Identity: 30%
PDB header:signaling protein
Chain: A: PDB Molecule:rhogap protein;
PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase

Phyre2

PDB 1f7c chain A

3D model

Region: 248 - 419
Aligned: 168
Modelled: 172
Confidence: 100.0%
Identity: 30%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 1pbw chain A

3D model

Region: 236 - 413
Aligned: 177
Modelled: 178
Confidence: 100.0%
Identity: 23%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 1pbw chain B

3D model

Region: 236 - 414
Aligned: 178
Modelled: 179
Confidence: 100.0%
Identity: 22%
PDB header:phosphotransferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase;
PDBTitle: structure of bcr-homology (bh) domain

Phyre2

PDB 3eap chain D

3D model

Region: 225 - 419
Aligned: 173
Modelled: 195
Confidence: 100.0%
Identity: 27%
PDB header:hydrolase activator
Chain: D: PDB Molecule:rho gtpase-activating protein 11a;
PDBTitle: crystal structure of the rhogap domain of arhgap11a

Phyre2

PDB 2xs6 chain A

3D model

Region: 234 - 414
Aligned: 161
Modelled: 181
Confidence: 100.0%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of the rhogap domain of human pik3r2

Phyre2
1
c1xa6A_
2
c3iugA_
3
c3byiA_
4
c3kuqA_
5
c2ee5A_
6
d1tx4a_
7
c2ngrB_
8
d1xa6a1
9
c3fk2B_
10
c3qisA_
11
c3msxB_
12
d1xa6a2
13
c2ovjA_
14
c2qv2A_
15
c1f7cA_
16
d1f7ca_
17
d1pbwa_
18
c1pbwB_
19
c3eapD_
20
c2xs6A_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1xa6A_
100.0 40 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
2c3iugA_
100.0 32 PDB header:splicing
Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics;
PDBTitle: crystal structure of the rhogap domain of rics
3c3byiA_
100.0 30 PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 15;
PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15)
4c3kuqA_
100.0 27 PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 7;
PDBTitle: crystal structure of the dlc1 rhogap domain
5c2ee5A_
100.0 28 PDB header:hydrolase
Chain: A: PDB Molecule:rho gtpase activating protein 5 variant;
PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant
6d1tx4a_
100.0 24 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
7c2ngrB_
100.0 23 PDB header:hydrolase
Chain: B: PDB Molecule:protein (gtpase activating protein (rhg));
PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap.
8d1xa6a1
100.0 36 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
9c3fk2B_
100.0 30 PDB header:signaling protein, hydrolase activator
Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1;
PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1
10c3qisA_
100.0 17 PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl
11c3msxB_
100.0 23 PDB header:protein binding
Chain: B: PDB Molecule:rho gtpase-activating protein 20;
PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20
12d1xa6a2
100.0 41 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
13c2ovjA_
100.0 32 PDB header:signaling protein
Chain: A: PDB Molecule:rac gtpase-activating protein 1;
PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap.
14c2qv2A_
100.0 18 PDB header:hydrolase
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway
15c1f7cA_
100.0 30 PDB header:signaling protein
Chain: A: PDB Molecule:rhogap protein;
PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase
16d1f7ca_
100.0 30 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
17d1pbwa_
100.0 23 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
18c1pbwB_
100.0 22 PDB header:phosphotransferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase;
PDBTitle: structure of bcr-homology (bh) domain
19c3eapD_
100.0 27 PDB header:hydrolase activator
Chain: D: PDB Molecule:rho gtpase-activating protein 11a;
PDBTitle: crystal structure of the rhogap domain of arhgap11a
20c2xs6A_
100.0 23 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of the rhogap domain of human pik3r2
21c3ps5A_
not modelled 99.8 27 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
22c2b3oA_
not modelled 99.8 27 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
23c3hizB_
not modelled 99.7 22 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
24c2shpA_
not modelled 99.7 30 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
25c2fo0A_
not modelled 99.7 36 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
26c1rqqC_
not modelled 99.7 26 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
27c2ozoA_
not modelled 99.7 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
28d2oq1a1
not modelled 99.7 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29c2y3aB_
not modelled 99.6 21 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
30c4fl2A_
not modelled 99.6 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
31c2oq1A_
not modelled 99.6 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
32c1k9aB_
not modelled 99.6 35 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
33d2izva2
not modelled 99.6 16 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34c1oplA_
not modelled 99.6 36 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
35c2izvA_
not modelled 99.6 17 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
36d1a81a1
not modelled 99.6 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37c2vifA_
not modelled 99.6 24 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
38c2lqnA_
not modelled 99.6 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
39c1x6cA_
not modelled 99.6 29 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
40c2ci8A_
not modelled 99.6 27 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
41d1rpya_
not modelled 99.6 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42c2c9wA_
not modelled 99.6 35 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
43c2hdxB_
not modelled 99.6 33 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
44d2shpa2
not modelled 99.6 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c2eo6A_
not modelled 99.6 29 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
46d1nrva_
not modelled 99.6 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d2eyva1
not modelled 99.6 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d2oq1a2
not modelled 99.6 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49d1r1qa_
not modelled 99.6 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d1fhsa_
not modelled 99.6 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51c2gsbA_
not modelled 99.6 20 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
52c2hmhA_
not modelled 99.6 21 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
53c2ysxA_
not modelled 99.6 37 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
54c2el8A_
not modelled 99.6 24 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
55d1a81e1
not modelled 99.6 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56c2eobA_
not modelled 99.6 23 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
57c2dlzA_
not modelled 99.6 23 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
58c2crhA_
not modelled 99.6 22 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
59c2ablA_
not modelled 99.6 30 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
60c3gqiB_
not modelled 99.6 24 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
61d2shpa3
not modelled 99.6 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62d1ayaa_
not modelled 99.6 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c1ka6A_
not modelled 99.6 31 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
64d3c7ia1
not modelled 99.5 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65d1rjaa_
not modelled 99.5 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66d1jwoa_
not modelled 99.5 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67c1y57A_
not modelled 99.5 38 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
68d1jyra_
not modelled 99.5 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2eo3A_
not modelled 99.5 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
70d1k9aa2
not modelled 99.5 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71c2dlyA_
not modelled 99.5 28 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
72c1x27F_
not modelled 99.5 22 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
73d1a81a2
not modelled 99.5 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c2kk6A_
not modelled 99.5 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
75d1a81e2
not modelled 99.5 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1d4ta_
not modelled 99.5 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d2c9wa2
not modelled 99.5 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c2lctA_
not modelled 99.5 20 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
79c2c0iA_
not modelled 99.5 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
80c1a81E_
not modelled 99.5 27 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
81c2dcrA_
not modelled 99.5 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
82d1opka2
not modelled 99.5 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83c2h8hA_
not modelled 99.5 38 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
84c2knoA_
not modelled 99.5 18 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
85d1mila_
not modelled 99.5 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86d1pica_
not modelled 99.5 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87d1i3za_
not modelled 99.5 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88d1csya_
not modelled 99.5 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c2eyzA_
not modelled 99.5 26 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
90d1lkka_
not modelled 99.5 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91d1blja_
not modelled 99.5 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
92c2augB_
not modelled 99.5 28 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
93d2qmsa1
not modelled 99.5 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1qada_
not modelled 99.5 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95d1cwea_
not modelled 99.5 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
96d2cs0a1
not modelled 99.5 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97c2dvjA_
not modelled 99.5 28 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
98d1qcfa2
not modelled 99.5 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
99c3gxxB_
not modelled 99.5 15 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
100d1bkla_
not modelled 99.5 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101d1f2fa_
not modelled 99.4 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
102c2eyyA_
not modelled 99.4 27 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
103c3nhnA_
not modelled 99.4 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
104d2fcia1
not modelled 99.4 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105c3mazA_
not modelled 99.4 17 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
106d1fu6a_
not modelled 99.4 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
107d1o48a_
not modelled 99.4 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
108c2ge9A_
not modelled 99.4 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
109c3qwyA_
not modelled 99.4 24 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
110d1g83a2
not modelled 99.4 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
111d1luia_
not modelled 99.4 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
112c3qwxX_
not modelled 99.3 22 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
113c2cr4A_
not modelled 99.3 24 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
114c1g83A_
not modelled 99.3 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
115c3or8A_
not modelled 99.3 20 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
116c3pfqA_
not modelled 99.3 35 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
117d1xa6a3
not modelled 99.3 52 Fold:Cysteine-rich domain
Superfamily:Cysteine-rich domain
Family:Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)
118d1uura3
not modelled 99.3 16 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
119c2ekxA_
not modelled 99.3 24 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
120c2e73A_
not modelled 99.3 32 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c gamma type;
PDBTitle: solution structure of the phorbol esters/diacylglycerol2 binding domain of protein kinase c gamma

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite